Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	RAG2 WASHC2C WASHC2A ARAP1	2.19e-05	49	67	4	GO:0005547
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate binding	RAG2 WASHC2C WASHC2A	1.52e-04	31	67	3	GO:0080025
GeneOntologyMolecularFunction	methylated histone binding	RAG2 CHD5 CHD8 DPF2	2.00e-04	86	67	4	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	RAG2 CHD5 CHD8 DPF2	2.18e-04	88	67	4	GO:0140034
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	RAG2 WASHC2C WASHC2A	2.19e-04	35	67	3	GO:0043325
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD5 CHD8 CHD3	2.59e-04	37	67	3	GO:0140658
GeneOntologyMolecularFunction	histone binding	RAG2 CHD5 CHD8 CHD3 DPF2 APLF	2.62e-04	265	67	6	GO:0042393
GeneOntologyMolecularFunction	retromer complex binding	WASHC2C WASHC2A	4.91e-04	10	67	2	GO:1905394
GeneOntologyMolecularFunction	modification-dependent protein binding	RAG2 CHD5 CHD8 DPF2 APLF	6.40e-04	206	67	5	GO:0140030
GeneOntologyMolecularFunction	helicase activity	IFIH1 CHD5 CHD8 CHD3	1.96e-03	158	67	4	GO:0004386
HumanPheno	Abnormal gesture use	KMT5B CHD8	2.13e-05	2	24	2	HP:4000090
HumanPheno	Epicanthus	SOX5 NBAS KMT5B PIEZO1 CHD5 SUPT16H DYNC2I1 CHD8 CHD3 DPF2 MED13L	4.06e-05	614	24	11	HP:0000286
Domain	FAM21	WASHC2C WASHC2A	1.31e-05	2	68	2	IPR027308
Domain	CHDCT2	CHD5 CHD3	3.91e-05	3	68	2	PF08074
Domain	CHDNT	CHD5 CHD3	3.91e-05	3	68	2	PF08073
Domain	DUF1086	CHD5 CHD3	3.91e-05	3	68	2	IPR009462
Domain	DUF1087	CHD5 CHD3	3.91e-05	3	68	2	IPR009463
Domain	CHD_N	CHD5 CHD3	3.91e-05	3	68	2	IPR012958
Domain	CHD_C2	CHD5 CHD3	3.91e-05	3	68	2	IPR012957
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	3.91e-05	3	68	2	IPR029341
Domain	DUF1087	CHD5 CHD3	3.91e-05	3	68	2	PF06465
Domain	DUF1086	CHD5 CHD3	3.91e-05	3	68	2	PF06461
Domain	DUF1087	CHD5 CHD3	3.91e-05	3	68	2	SM01147
Domain	DUF1086	CHD5 CHD3	3.91e-05	3	68	2	SM01146
Domain	CAP-ZIP_m	WASHC2C WASHC2A	3.91e-05	3	68	2	PF15255
Domain	Chromo_domain	CHD5 CHD8 CHD3	8.84e-05	24	68	3	IPR023780
Domain	Chromo	CHD5 CHD8 CHD3	1.13e-04	26	68	3	PF00385
Domain	CHROMO_1	CHD5 CHD8 CHD3	1.42e-04	28	68	3	PS00598
Domain	CHROMO_2	CHD5 CHD8 CHD3	1.42e-04	28	68	3	PS50013
Domain	SNF2_N	CHD5 CHD8 CHD3	2.12e-04	32	68	3	IPR000330
Domain	Chromodomain-like	CHD5 CHD8 CHD3	2.12e-04	32	68	3	IPR016197
Domain	SNF2_N	CHD5 CHD8 CHD3	2.12e-04	32	68	3	PF00176
Domain	Chromo/shadow_dom	CHD5 CHD8 CHD3	2.33e-04	33	68	3	IPR000953
Domain	CHROMO	CHD5 CHD8 CHD3	2.33e-04	33	68	3	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 CHD8 CHD3	2.78e-04	35	68	3	IPR002464
Domain	DEAH_ATP_HELICASE	CHD5 CHD8 CHD3	3.55e-04	38	68	3	PS00690
Domain	ZF_PHD_2	RAG2 CHD5 CHD3 DPF2	3.99e-04	95	68	4	PS50016
Domain	ZF_PHD_1	RAG2 CHD5 CHD3 DPF2	4.15e-04	96	68	4	PS01359
Domain	Helicase_C	IFIH1 CHD5 CHD8 CHD3	6.26e-04	107	68	4	PF00271
Domain	HELICc	IFIH1 CHD5 CHD8 CHD3	6.26e-04	107	68	4	SM00490
Domain	Helicase_C	IFIH1 CHD5 CHD8 CHD3	6.48e-04	108	68	4	IPR001650
Domain	HELICASE_CTER	IFIH1 CHD5 CHD8 CHD3	6.71e-04	109	68	4	PS51194
Domain	HELICASE_ATP_BIND_1	IFIH1 CHD5 CHD8 CHD3	6.71e-04	109	68	4	PS51192
Domain	DEXDc	IFIH1 CHD5 CHD8 CHD3	6.71e-04	109	68	4	SM00487
Domain	Helicase_ATP-bd	IFIH1 CHD5 CHD8 CHD3	6.94e-04	110	68	4	IPR014001
Domain	-	SOX5 CHD5 CHD3	1.06e-03	55	68	3	1.10.30.10
Domain	HMG_box_dom	SOX5 CHD5 CHD3	1.72e-03	65	68	3	IPR009071
Domain	Znf_FYVE_PHD	RAG2 CHD5 CHD3 DPF2	2.03e-03	147	68	4	IPR011011
Domain	PHD	CHD5 CHD3 DPF2	2.58e-03	75	68	3	PF00628
Domain	Znf_PHD-finger	CHD5 CHD3 DPF2	3.00e-03	79	68	3	IPR019787
Domain	PHD	CHD5 CHD3 DPF2	4.19e-03	89	68	3	SM00249
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CAND2 RBM27 VPS13C PIEZO1 CHD5 CHD8 BCOR CFAP97 ARHGEF10L ARAP1	8.04e-08	529	68	10	14621295
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	UBE2R2 RANBP2 SUPT16H DYNC2I1 CHD8 CLSPN BCOR	3.68e-07	232	68	7	25515538
Pubmed	Human transcription factor protein interaction networks.	SOX5 MFAP1 PPAN RBM27 CHD5 CHD8 CHD3 LTV1 CEP192 DPF2 BCOR WASHC2A TFDP1 PPM1G	5.65e-07	1429	68	14	35140242
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GPAM CHD8 CEP192 BCOR ARHGEF10L	1.68e-06	101	68	5	10997877
Pubmed	Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity.	PPP1R9A PPP1R9B	3.77e-06	2	68	2	16600521
Pubmed	Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay.	SUPT16H CHD8	3.77e-06	2	68	2	26834018
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	3.77e-06	2	68	2	15847701
Pubmed	Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin.	PPP1R9A PPP1R9B	3.77e-06	2	68	2	28700667
Pubmed	A distinct neurodevelopmental syndrome with intellectual disability, autism spectrum disorder, characteristic facies, and macrocephaly is caused by defects in CHD8.	SUPT16H CHD8	3.77e-06	2	68	2	30670789
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	3.77e-06	2	68	2	20827171
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	3.77e-06	2	68	2	36717248
Pubmed	Neurodevelopmental phenotype associated with CHD8-SUPT16H duplication.	SUPT16H CHD8	3.77e-06	2	68	2	31823155
Pubmed	Neurabin contributes to hippocampal long-term potentiation and contextual fear memory.	PPP1R9A PPP1R9B	3.77e-06	2	68	2	18183288
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	NBAS MFAP1 CAND2 LEMD3 PIEZO1 CLNS1A SUPT16H LTV1 CEP192 SEC63 WASHC2A TFDP1 PPM1G	5.29e-06	1487	68	13	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CASC3 ZC3H14 RANBP2 PPAN RBM27 LEMD3 WASF2 PIEZO1 PPP1R9A CHD8 SEC63 BCOR TTF1	5.69e-06	1497	68	13	31527615
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	AVEN RANBP2 WASHC2C VPS13C WASF2 DYNC2I1 LTV1 CEP192 WASHC2A CFAP97	6.01e-06	853	68	10	28718761
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	LEMD3 LTV1 CLSPN BCOR WASHC2A PPM1G	8.14e-06	242	68	6	34011540
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	ZC3H14 RANBP2 PPAN RBM27 LEMD3 WASF2 SUPT16H PPP1R9B LTV1	8.90e-06	701	68	9	30196744
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MFAP1 UBE2R2 KMT5B CHD5 SUPT16H CHD8 CHD3 DPF2 CLSPN BCOR TFDP1	1.02e-05	1116	68	11	31753913
Pubmed	A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.	CHD3 RGS3	1.13e-05	3	68	2	30971721
Pubmed	Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.	RAG2 PIEZO1	1.13e-05	3	68	2	38530239
Pubmed	Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors.	PPP1R9A PPP1R9B	1.13e-05	3	68	2	17464283
Pubmed	Expression and function of a novel isoform of Sox5 in malignant B cells.	SOX5 CD19	1.13e-05	3	68	2	24418753
Pubmed	Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton.	PPP1R9A PPP1R9B	1.13e-05	3	68	2	9653190
Pubmed	Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.	RAG2 CD19	1.13e-05	3	68	2	17658281
Pubmed	Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus.	IFIH1 CD19	1.13e-05	3	68	2	19414755
Pubmed	The first 3 days of B-cell development in the mouse embryo.	RAG2 CD19	1.13e-05	3	68	2	12393735
Pubmed	Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.	PPP1R9A PPP1R9B	1.13e-05	3	68	2	20305656
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CASC3 NBAS MFAP1 LEMD3 VPS13C DYNC2I1 SEC63 CLSPN WASHC2A	1.27e-05	733	68	9	34672954
Pubmed	A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.	SOX5 CASC3 ANKRD12 TFDP1	1.31e-05	73	68	4	22094256
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	NBAS RANBP2 WASHC2C LEMD3 DYNC2I1 LTV1 CEP192 DPF2 WASHC2A CFAP97 ARAP1	1.40e-05	1155	68	11	20360068
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	RBM27 CHD8 CHD3 DPF2 MED13L BCOR	1.45e-05	268	68	6	33640491
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	PPAN DPF2 SEC63 BCOR	1.71e-05	78	68	4	28611094
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	MFAP1 RBM27 SUPT16H CHD8 CHD3 PPM1G	1.97e-05	283	68	6	30585729
Pubmed	Functional proteomics mapping of a human signaling pathway.	SOX5 LEMD3 NID1 PPP1R9B CHD3 KIF13A TTF1 RGS3	2.00e-05	591	68	8	15231748
Pubmed	Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.	RAG2 CD19	2.25e-05	4	68	2	23740949
Pubmed	Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton.	PPP1R9A PPP1R9B	2.25e-05	4	68	2	12270929
Pubmed	Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor.	RAG2 PIEZO1	2.25e-05	4	68	2	38744281
Pubmed	c-Myb is required for pro-B cell differentiation.	RAG2 CD19	2.25e-05	4	68	2	19843942
Pubmed	B-cell development fails in the absence of the Pbx1 proto-oncogene.	RAG2 CD19	2.25e-05	4	68	2	17244677
Pubmed	Structural basis for protein phosphatase 1 regulation and specificity.	PPP1R9A PPP1R9B	2.25e-05	4	68	2	22284538
Pubmed	Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin.	PPP1R9A PPP1R9B	2.25e-05	4	68	2	29786422
Pubmed	Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.	RAG2 CD19	2.25e-05	4	68	2	25044405
Pubmed	The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging.	RAG2 CD19	2.25e-05	4	68	2	24177426
Pubmed	The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.	PPP1R9A PPP1R9B	2.25e-05	4	68	2	12016225
Pubmed	Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin.	PPP1R9A PPP1R9B	2.25e-05	4	68	2	10514494
Pubmed	Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins.	ZC3H14 DYNC2I1 TFDP1 ARAP1	2.29e-05	84	68	4	34159380
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ZC3H14 MFAP1 RANBP2 RBM27 SUPT16H CHD8 CHD3 DPF2 MED13L PPM1G	2.67e-05	1014	68	10	32416067
Pubmed	A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin.	PPP1R9A PPP1R9B	3.75e-05	5	68	2	15016827
Pubmed	Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis.	IFIH1 RAG2	3.75e-05	5	68	2	35168003
Pubmed	Spinophilin Is Indispensable for the α2B Adrenergic Receptor-Elicited Hypertensive Response.	PPP1R9A PPP1R9B	3.75e-05	5	68	2	26244553
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	CASC3 MFAP1 PPAN RBM27 CLNS1A CHD3 SEC63 PPM1G	4.06e-05	653	68	8	33742100
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	KMT5B CHD5 CHD3	4.47e-05	35	68	3	27142060
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	UBE2R2 CAND2 WASHC2C CHD3 CEP192 ANKRD12 SEC63 BCOR KIF13A WASHC2A	4.68e-05	1084	68	10	11544199
Pubmed	CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism.	WASHC2C CLNS1A LTV1 SEC63 PPM1G	4.76e-05	201	68	5	34917906
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	MFAP1 RBM27 CHD8 CLSPN BCOR TFDP1	5.40e-05	339	68	6	30415952
Pubmed	Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.	RAG2 CD19	5.62e-05	6	68	2	30002144
Pubmed	Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion.	PPP1R9B KIF13A	5.62e-05	6	68	2	19094064
Pubmed	c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6.	RAG2 CD19	5.62e-05	6	68	2	21300982
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	MFAP1 RANBP2 PPAN PIEZO1 TTF1	5.86e-05	210	68	5	16565220
Pubmed	Interaction network of human early embryonic transcription factors.	SOX5 RANBP2 CHD8 DPF2 BCOR TFDP1	6.54e-05	351	68	6	38297188
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	ZC3H14 WASHC2C BCOR WASHC2A PPM1G	6.55e-05	215	68	5	35973513
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	MFAP1 RBM27 CHD5 CLNS1A SUPT16H CHD8 CHD3 LTV1 CEP192 PPM1G	7.83e-05	1153	68	10	29845934
Pubmed	Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.	CHD8 CHD3	7.86e-05	7	68	2	26816381
Pubmed	Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression.	RAG2 CD19	7.86e-05	7	68	2	23109711
Pubmed	Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.	RAG2 CD19	7.86e-05	7	68	2	17911595
Pubmed	LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.	RAG2 CD19	7.86e-05	7	68	2	30049881
Pubmed	In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells.	RAG2 CD19	7.86e-05	7	68	2	25727904
Pubmed	The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity.	RAG2 CD19	7.86e-05	7	68	2	31328158
Pubmed	The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology.	PPP1R9A PPP1R9B	7.86e-05	7	68	2	15996550
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	CHD8 CLSPN BCOR PPM1G	8.11e-05	116	68	4	30804394
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZC3H14 RANBP2 WASHC2C RBM27 WASF2 PPP1R9B CHD3 LTV1 BCOR	8.34e-05	934	68	9	33916271
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	RANBP2 LEMD3 CHD8 PPM1G	9.56e-05	121	68	4	22412018
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZC3H14 MFAP1 RANBP2 RBM27 LEMD3 SUPT16H CHD8 CHD3 BCOR	9.79e-05	954	68	9	36373674
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	1.05e-04	8	68	2	19922874
Pubmed	Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection.	RAG2 CD19	1.05e-04	8	68	2	25657250
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CASC3 RANBP2 KCNA4 WASF2 PPP1R9A SUPT16H PPP1R9B CHD8 BCOR	1.05e-04	963	68	9	28671696
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	RANBP2 RBM27 SUPT16H CHD8 CHD3 PPM1G	1.23e-04	394	68	6	27248496
Pubmed	Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.	RAG2 CD19	1.34e-04	9	68	2	32522871
Pubmed	Essential role of PDZ-RGS3 in the maintenance of neural progenitor cells.	SOX5 RGS3	1.34e-04	9	68	2	20629178
Pubmed	ILC3s control splenic cDC homeostasis via lymphotoxin signaling.	RAG2 CD19	1.34e-04	9	68	2	33724364
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	NBAS WASHC2C RBM27 PPP1R9B WASHC2A	1.35e-04	251	68	5	29778605
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	ZC3H14 SUPT16H NID1 LTV1 PPM1G	1.35e-04	251	68	5	28077445
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	BDP1 CASC3 VPS13C PPP1R9A DYNC2I1 PPP1R9B CHD3 CEP192 ANKRD12 TTF1 ARAP1	1.39e-04	1489	68	11	28611215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WASHC2C PPP1R9A CEP192 ANKRD12 MED13L WASHC2A	1.47e-04	407	68	6	12693553
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BDP1 WASHC2C CEP192 CLSPN BCOR WASHC2A PPM1G	1.51e-04	588	68	7	38580884
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	ZC3H14 MFAP1 PPAN RBM27 CHD5 SUPT16H PPP1R9B LTV1 SEC63 PPM1G	1.59e-04	1257	68	10	36526897
Pubmed	Genetic control of neuroadapted sindbis virus replication in female mice maps to chromosome 2 and associates with paralysis and mortality.	RAG2 KCNA4	1.68e-04	10	68	2	11507212
Pubmed	A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.	CD19 KMT5B	1.68e-04	10	68	2	27320916
Pubmed	Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.	PPP1R9A PPP1R9B	1.68e-04	10	68	2	20124353
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	CHD5 SUPT16H CHD8 CHD3 BCOR TFDP1 PPM1G	1.86e-04	608	68	7	36089195
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	RANBP2 CLNS1A MED13L RGS3 ZNF654	1.97e-04	272	68	5	31010829
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RANBP2 LEMD3 PPP1R9A CLNS1A SUPT16H PPP1R9B CEP192 BCOR PPM1G	1.99e-04	1049	68	9	27880917
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZC3H14 MFAP1 RANBP2 RBM27 LEMD3 POLR2F SUPT16H CHD3 BCOR TTF1	2.01e-04	1294	68	10	30804502
Pubmed	The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.	CHD3 BCOR	2.05e-04	11	68	2	23658227
Pubmed	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.	SUPT16H PPM1G	2.05e-04	11	68	2	18406329
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	MFAP1 RBM27 TTF1 PPM1G	2.08e-04	148	68	4	32538781
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	RANBP2 SUPT16H CHD8 DPF2	2.18e-04	150	68	4	28242625
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RANBP2 PPAN RBM27 LEMD3 SUPT16H CHD8	2.24e-04	440	68	6	34244565
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	CASC3 MFAP1 RANBP2 PPAN RBM27 SUPT16H CHD8 LTV1 SEC63 TTF1	2.32e-04	1318	68	10	30463901
Interaction	CBX3 interactions	MFAP1 RBM27 LEMD3 CHD5 SUPT16H CHD8 CHD3 CLSPN BCOR TFDP1 PPM1G	8.47e-06	646	67	11	int:CBX3
Interaction	NUP50 interactions	ZC3H14 MFAP1 RANBP2 RBM27 LEMD3 CLSPN BCOR PPM1G	1.69e-05	341	67	8	int:NUP50
Interaction	POLR1E interactions	MFAP1 RANBP2 POLR2F SUPT16H CHD8 TTF1 TFDP1 PPM1G	2.04e-05	350	67	8	int:POLR1E
Interaction	FBXW11 interactions	UBE2R2 RANBP2 FOXN2 SUPT16H DYNC2I1 CHD8 C1orf210 CLSPN BCOR	2.56e-05	473	67	9	int:FBXW11
Interaction	H2AC8 interactions	EID1 SUPT16H LTV1 CLSPN APLF PPM1G	2.70e-05	177	67	6	int:H2AC8
Interaction	CARD8 interactions	CARD6 CHD8 CEP192 BCOR	4.73e-05	60	67	4	int:CARD8
Interaction	KPNB1 interactions	ZC3H14 RANBP2 POLR2F PPP1R9B CHD8 CHD3 LTV1 CEP192 PPM1G	7.56e-05	544	67	9	int:KPNB1
Cytoband	6q24.2	PHACTR2 LTV1	2.90e-04	17	68	2	6q24.2
GeneFamily	WASH complex	WASHC2C WASHC2A	8.63e-05	6	44	2	1331
GeneFamily	PHD finger proteins\|NuRD complex	CHD5 CHD3	3.76e-04	12	44	2	1305
GeneFamily	PHD finger proteins	CHD5 CHD3 DPF2	1.36e-03	90	44	3	88
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	IFIH1 CARD6	2.41e-03	30	44	2	959
GeneFamily	Zinc fingers CCCH-type	ZC3H14 RBM27	3.27e-03	35	44	2	73
GeneFamily	PDZ domain containing	PPP1R9A PPP1R9B RGS3	6.00e-03	152	44	3	1220
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	BDP1 TTF1	7.37e-03	53	44	2	532
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R9A PPP1R9B CEP192	9.67e-03	181	44	3	694
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	BDP1 IFIH1 MFAP1 RBM27 VPS13C DYNC2I1 NID1 RNF13 CEP192 SEC63 CDH19 ZNF654	1.11e-07	656	68	12	M18979
Coexpression	GSE44649_NAIVE_VS_ACTIVATED_CD8_TCELL_MIR155_KO_DN	BDP1 FOXN2 KMT5B RNF13 CEP192 ZNF654	1.35e-05	200	68	6	M9777
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	BDP1 MFAP1 PPAN DYNC2I1 ANKRD12 CLSPN TTF1	2.14e-08	197	68	7	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	RBM27 VPS13C NID1 ANKRD12 SEC63 CFAP97	6.05e-07	199	68	6	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSRNP1 RANBP2 WASF2 CHD3 ANKRD12	9.91e-06	187	68	5	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG2 CD19 SUPT16H GPAM SEC63	1.18e-05	194	68	5	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BDP1 AVEN FOXN2 SLC22A15 BCOR	1.24e-05	196	68	5	7e98380d815fbf6254289ace2af37aac6fef51e8
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	PHACTR2 VPS13C DYNC2I1 RNF13 ANKRD12	1.31e-05	198	68	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	PHACTR2 VPS13C RNF13 ANKRD12 CFAP97	1.34e-05	199	68	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(00)_Basal-(2)_GFP_FOXI1\|(00)_Basal / shred by cell type by condition	RBM27 EID1 NID1 ANKRD12 CFAP97	1.34e-05	199	68	5	19674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 IFIH1 VPS13C ANKRD12 MED13L	1.37e-05	200	68	5	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	Intellectual Disability	ZC3H14 SUPT16H RNF13 CHD8 CHD3 DPF2 MED13L	5.70e-05	447	65	7	C3714756
Disease	Global developmental delay	NBAS SUPT16H RNF13 CHD3	2.16e-04	133	65	4	C0557874
Disease	Macrocephaly	CHD8 CHD3	2.59e-04	11	65	2	C0221355
Disease	mean corpuscular hemoglobin concentration	SOX5 UBE2R2 KCNA4 WASHC2C PIEZO1 TIGD4 ANKRD12 CLSPN ZNF654	6.81e-04	1105	65	9	EFO_0004528
Disease	glucose measurement	SOX5 CAND2 VPS13C ARAP1 PPM1G	1.51e-03	380	65	5	EFO_0004468

Protein segments in the cluster

Peptide	Gene	Start	Entry
FYYEDDSEGEDIEKE	TTF1	866	Q15361
SQEEDDDADDFESDY	BDP1	1871	A6H8Y1
PGEAFEFDDSDDEED	ARHGEF10L	31	Q9HCE6
DEDEEDDDDLSQGYD	CHD8	2541	Q9HCK8
DSFLDDEEEDYEPTD	APLF	466	Q8IW19
EGEDDYYTDGEESSD	CFAP97	126	Q9P2B7
EYSIGSEDEDEDFEE	CHD5	1371	Q8TDI0
DYEDDKDDDISDTFS	CREBRF	391	Q8IUR6
SALDEYEFKDDDDEE	ANKRD12	356	Q6UB98
QDDDDDAYSDVFEFE	BCOR	1626	Q6W2J9
NSFDGDDEFDTYNED	RAG2	391	P55895
DDEFDTYNEDDEEDE	RAG2	396	P55895
YVSEEEEDDEDFETA	RANBP2	2666	P49792
FLPDDDDEDEDEYES	RBM27	1041	Q9P2N5
EDEDEDTSDDNYGER	RGS3	896	P49796
ENYSDSEEEDDDDVA	LEMD3	256	Q9Y2U8
GEESESESEYEEYTD	MFAP1	176	P55081
EESKEEDELGYDDDF	MED13L	251	Q71F56
EDVDDEKGDSNDDYD	LTV1	191	Q96GA3
DADDDAFEEYSADVE	MTURN	101	Q8N3F0
SFSDSDFGGEEEEEE	CSRNP1	396	Q96S65
SSEGDEEEDDYDDDF	KMT5B	831	Q4FZB7
EEEDDYDDDFEDDFI	KMT5B	836	Q4FZB7
DDFEDYEDDFEVCDG	DYNC2I1	376	Q8WVS4
YEDDFEVCDGDDDES	DYNC2I1	381	Q8WVS4
AEDEDDDGFIEDNYI	C1orf210	81	Q8IVY1
EDEGEEFDDWEDDYD	EID1	96	Q9Y6B2
LGTEDGAEYDDEDED	NID1	281	P14543
DAFDSYCEESDEEEE	NEK11	481	Q8NG66
YTDDEDEDEDEDGSG	PHACTR2	451	O75167
EDEGEEDSDSDYEIS	NBAS	466	A2RRP1
GEDSEEDEDTEYFDA	OSBP2	441	Q969R2
DEDSDDYDGEEYDVE	CLNS1A	141	P54105
YDGEEDFENSETTEF	CARD6	241	Q9BX69
DYESAEDSEGEEGEY	CASC3	91	O15234
EDDSDAETYGEENDE	AVEN	91	Q9NQS1
EPDSEEDSEFYENDS	CD19	411	P15391
SEYSVGSEEEDEDFD	CHD3	1361	Q12873
IEDDSDEGGDDEYCD	IFIH1	641	Q9BYX4
DSSDDDIDDEMFYDD	CEP192	211	Q8TEP8
GFHSEEDTDVDYEDD	FOXN2	346	P32314
EFSEQESEDEYSDDD	CAND2	331	O75155
LGSESEEEEEFYDAD	SLC22A15	526	Q8IZD6
YDDEGGGEEDTEAFD	CDH19	641	Q9H159
DDEDGDDMDSYQEED	KIF13A	1076	Q9H1H9
EDEDSDFGEEQRDCY	GPAM	691	Q9HCL2
EEDSEECSEEEDGYS	PPM1G	271	O15355
TESSDYEEDDNEDTD	RNF13	336	O43567
YEEDDNEDTDSSDAE	RNF13	341	O43567
DNFDGDDFDDVEEDE	POLR2F	6	P61218
EEDDNDDDDVSTEYG	HRC	301	P23327
EEEEEDSDEDYSSEA	SUPT16H	956	Q9Y5B9
DDQGDEEEDDHAYEG	ARAP1	276	Q96P48
GSEDEYDGEEIDEYE	CLSPN	1066	Q9HAW4
SYVGEDDEEDDDFNE	TFDP1	391	Q14186
GEDDDEQEDDDIEYF	PPAN	376	Q9NQ55
SDETGFYTSDEEDDD	TIGD4	446	Q8IY51
CGDDYEEEEDEEGDY	ZNF654	696	Q8IZM8
DDFLDDLDDEDYEED	DPF2	161	Q92785
DEDQEDSEGFEDSFE	SEC63	736	Q9UGP8
FDDDDGDDDDDFFSA	WASHC2C	451	Q9Y4E1
ESESDDEYFDAEDGE	VPS13C	871	Q709C8
YSDSEDDSSEFDEDD	WASF2	481	Q9Y6W5
FDDDDGDDDDDFFSA	WASHC2A	451	Q641Q2
EEEDDPDVDYGSDSE	SOX5	741	P35711
EEEDADCYDDDDSGN	UBE2R2	221	Q712K3
GDYFLFESDSEEEEE	PIEZO1	1416	Q92508
EEEAYEEDADSEFPE	PRR23C	151	Q6ZRP0
DGEEEEEDDDYGSRT	ZC3H14	311	Q6PJT7
EEEEEEEGRFYYSED	KCNA4	131	P22459
ADDDETGEYATDEEE	PPP1R9A	626	Q9ULJ8
YGEDDEETGEYATDE	PPP1R9B	616	Q96SB3