Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.52e-11261558GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

6.19e-09521558GO:0005272
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN8A SCN9A

5.00e-08141555GO:0031402
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

7.65e-0834315515GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

5.98e-0745915516GO:0005216
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN8A SCN9A

1.52e-06261555GO:0031420
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN10A CACNA1G GRIN3B

1.62e-0618215510GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN10A CACNA1G GRIN3B

1.79e-0618415510GO:0022832
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F CACNA1G

3.29e-06141554GO:0008331
GeneOntologyMolecularFunctionchannel activity

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

3.42e-0652515516GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

3.51e-0652615516GO:0022803
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B

3.55e-0646515515GO:0046873
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential

CACNA1C CACNA1D CACNA1G

4.54e-0651553GO:0086007
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

7.74e-061711559GO:0015081
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6

5.33e-05271554GO:0030548
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved SA node cell action potential

CACNA1D CACNA1G

5.99e-0521552GO:0086059
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

6.11e-0566415516GO:0008324
GeneOntologyMolecularFunctiongated channel activity

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN10A CACNA1G GRIN3B

6.18e-0533415511GO:0022836
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6

6.18e-05281554GO:0099602
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B

1.13e-0462715515GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

1.48e-0479315517GO:0015075
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in AV node cell action potential

CACNA1C CACNA1G

1.79e-0431552GO:0086056
GeneOntologyMolecularFunctionhistone H2AXS139 kinase activity

ATR ATM

1.79e-0431552GO:0035979
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B

2.78e-0475815516GO:0015318
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A SCN10A

2.88e-04171553GO:0099508
GeneOntologyMolecularFunctionprotein tyrosine/serine/threonine phosphatase activity

DUSP7 DUSP9 SBF1 SSH1

3.41e-04431554GO:0008138
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F CACNA1G

4.42e-04461554GO:0005245
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

IQSEC3 GAPVD1 DOCK8 DENND1C PLEKHG5 SBF1 TIAM1 DOCK6

4.55e-042311558GO:0005085
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1C CACNA1D CACNA1F GRIN2A CACNA1G GRIN3B

5.15e-041291556GO:0005262
GeneOntologyMolecularFunctionhistone H2AX kinase activity

ATR ATM

5.90e-0451552GO:0141003
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GABRB2 GRIN2A GRIN3B

8.24e-04241553GO:0099507
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1F GRIN2A CACNA1G GRIN3B

1.17e-031511556GO:0015085
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 CACNA1G

1.21e-031521556GO:0022843
GeneOntologyMolecularFunctionNMDA glutamate receptor activity

GRIN2A GRIN3B

1.63e-0381552GO:0004972
GeneOntologyMolecularFunctiontransporter activity

GABRB2 CACNA1C CACNA1D CACNA1F GRAMD1A GRIN2A KCNB2 C2CD2L SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B GRAMD1C UNC80

2.37e-03128915520GO:0005215
GeneOntologyMolecularFunctionMAP kinase tyrosine phosphatase activity

DUSP7 DUSP9

2.59e-03101552GO:0033550
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

PGA4 PGA5 PGA3

2.94e-03371553GO:0004190
GeneOntologyMolecularFunctionhistone H4K8 acetyltransferase activity

BRPF1 BRD1

3.14e-03111552GO:0043996
GeneOntologyMolecularFunctionhistone H4K5 acetyltransferase activity

BRPF1 BRD1

3.14e-03111552GO:0043995
GeneOntologyMolecularFunctionprotein tyrosine/threonine phosphatase activity

DUSP7 DUSP9

3.14e-03111552GO:0008330
GeneOntologyMolecularFunctionaspartic-type peptidase activity

PGA4 PGA5 PGA3

3.17e-03381553GO:0070001
GeneOntologyMolecularFunctionhistone H4K12 acetyltransferase activity

BRPF1 BRD1

3.75e-03121552GO:0043997
GeneOntologyMolecularFunctionarrestin family protein binding

GPR135 ARRB2

3.75e-03121552GO:1990763
GeneOntologyMolecularFunctionMAP kinase tyrosine/serine/threonine phosphatase activity

DUSP7 DUSP9

4.41e-03131552GO:0017017
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA1C CACNA1D SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

7.55e-143615210GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA1C CACNA1D SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

2.71e-116215210GO:0086002
GeneOntologyBiologicalProcesscardiac muscle cell contraction

CACNA1C CACNA1D GATA4 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

8.77e-119315211GO:0086003
GeneOntologyBiologicalProcesscardiac muscle cell action potential

CACNA1C CACNA1D SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

8.63e-108715210GO:0086001
GeneOntologyBiologicalProcessactin-mediated cell contraction

CACNA1C CACNA1D GATA4 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

2.58e-0912715211GO:0070252
GeneOntologyBiologicalProcesscardiac muscle contraction

CACNA1C CACNA1D GATA4 PPP1R13L SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

4.07e-0916715212GO:0060048
GeneOntologyBiologicalProcessactin filament-based movement

CACNA1C CACNA1D GATA4 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.84e-0815315211GO:0030048
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.99e-08631528GO:0019228
GeneOntologyBiologicalProcessmembrane depolarization

CACNA1C CACNA1D SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

2.21e-0812115210GO:0051899
GeneOntologyBiologicalProcessaction potential

CACNA1C CACNA1D GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

3.26e-0820115212GO:0001508
GeneOntologyBiologicalProcessstriated muscle contraction

CACNA1C CACNA1D GATA4 PPP1R13L SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

7.58e-0821715212GO:0006941
GeneOntologyBiologicalProcessmuscle contraction

CACNA1C CACNA1D GATA4 KCNB2 PPP1R13L PTGS1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.63e-0640015214GO:0006936
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.80e-061121528GO:0019226
GeneOntologyBiologicalProcessheart contraction

CACNA1C CACNA1D GATA4 PPP1R13L SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

2.23e-0629815212GO:0060047
GeneOntologyBiologicalProcessmuscle system process

CACNA1C CACNA1D GATA4 GATA5 KCNB2 PPP1R13L PTGS1 TIAM1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

2.97e-0654715216GO:0003012
GeneOntologyBiologicalProcessheart process

CACNA1C CACNA1D GATA4 PPP1R13L SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

3.24e-0630915212GO:0003015
GeneOntologyBiologicalProcessregulation of membrane potential

GABRB2 CACNA1C CACNA1D GRIN2A KCNB2 ARRB2 SSH1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B

3.91e-0655915216GO:0042391
GeneOntologyBiologicalProcessactin filament-based process

C15orf62 CACNA1C CACNA1D IQSEC3 PHACTR2 PPFIA1 ESPNL GATA4 OBSL1 NUAK2 SSH1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G SAMD14

1.27e-0591215220GO:0030029
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception of pain

GRIN2A ARRB2 SCN1A SCN9A SCN10A

1.56e-05431525GO:0062149
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

2.45e-052081529GO:0035725
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6

3.18e-05251524GO:0045737
GeneOntologyBiologicalProcessdetection of external stimulus

WHRN CACNA1F GRK7 GRIN2A ARRB2 SCN1A SCN9A SCN10A

4.38e-051731528GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

WHRN CACNA1F GRK7 GRIN2A ARRB2 SCN1A SCN9A SCN10A

4.75e-051751528GO:0009582
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6

5.06e-05281524GO:1904031
GeneOntologyBiologicalProcesstelomerase catalytic core complex assembly

ATR ATM

5.40e-0521522GO:1904868
GeneOntologyBiologicalProcesspositive regulation of telomerase catalytic core complex assembly

ATR ATM

5.40e-0521522GO:1904884
GeneOntologyBiologicalProcessregulation of telomerase catalytic core complex assembly

ATR ATM

5.40e-0521522GO:1904882
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

WHRN GRIN2A SCN1A SCN9A SCN10A

6.26e-05571525GO:0050974
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

CACNA1C SCN10A CACNA1G

8.22e-05121523GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

CACNA1C SCN10A CACNA1G

8.22e-05121523GO:0086016
GeneOntologyBiologicalProcesscell-cell signaling involved in cardiac conduction

CACNA1C CACNA1D SCN10A CACNA1G

1.11e-04341524GO:0086019
GeneOntologyBiologicalProcessestablishment of RNA localization to telomere

ATR ATM

1.61e-0431522GO:0097694
GeneOntologyBiologicalProcessestablishment of protein-containing complex localization to telomere

ATR ATM

1.61e-0431522GO:0097695
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

CACNA1C SCN10A CACNA1G

1.67e-04151523GO:0086067
GeneOntologyBiologicalProcesssodium ion transport

SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

2.08e-042751529GO:0006814
GeneOntologyBiologicalProcessdetection of mechanical stimulus

WHRN GRIN2A SCN1A SCN9A SCN10A

2.32e-04751525GO:0050982
GeneOntologyBiologicalProcessblood circulation

CACNA1C CACNA1D RAMP2 GATA4 PPP1R13L PTGS1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

3.20e-0464815214GO:0008015
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

WHRN CACNA1D ESPNL GRIN2A SCN1A SCN8A SCN9A SCN10A

3.94e-042381528GO:0050954
GeneOntologyBiologicalProcessmetal ion transport

CACNA1C CACNA1D CACNA1F JPH4 RAMP2 GRIN2A KCNB2 SLC6A12 ARRB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B

4.19e-04100015218GO:0030001
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1C CACNA1D CACNA1F CACNA1G

4.29e-04481524GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1C CACNA1D CACNA1F CACNA1G

4.29e-04481524GO:1902656
GeneOntologyBiologicalProcessadult walking behavior

CACNA1C ARRB2 SCN1A SCN8A

5.02e-04501524GO:0007628
GeneOntologyBiologicalProcessmembrane depolarization during SA node cell action potential

CACNA1D CACNA1G

5.32e-0451522GO:0086046
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

5.32e-0451522GO:1904879
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1C CACNA1D CACNA1F JPH4 GRIN2A KCNB2 SLC6A12 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

5.92e-0494215217GO:0098655
GeneOntologyBiologicalProcessmembrane depolarization during cardiac muscle cell action potential

CACNA1C CACNA1D CACNA1G

6.24e-04231523GO:0086012
GeneOntologyBiologicalProcessmembrane depolarization during AV node cell action potential

CACNA1C CACNA1G

7.94e-0461522GO:0086045
GeneOntologyBiologicalProcesstelomerase holoenzyme complex assembly

ATR ATM

7.94e-0461522GO:1905323
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1C CACNA1D CACNA1F JPH4 RAMP2 GRIN2A KCNB2 SLC6A12 ARRB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

8.78e-04115715219GO:0006812
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception of pain

ARRB2 SCN9A SCN10A

9.01e-04261523GO:0050965
GeneOntologyBiologicalProcesscell communication involved in cardiac conduction

CACNA1C CACNA1D SCN10A CACNA1G

9.42e-04591524GO:0086065
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.49e-13171528GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G UNC80

3.96e-13291529GO:0034706
GeneOntologyCellularComponentmonoatomic ion channel complex

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

1.75e-0837815216GO:0034702
GeneOntologyCellularComponentcation channel complex

CACNA1C CACNA1D CACNA1F KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G UNC80

1.81e-0823515213GO:0034703
GeneOntologyCellularComponenttransmembrane transporter complex

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

1.40e-0652315216GO:1902495
GeneOntologyCellularComponentaxon

TRIM46 WHRN CACNA1C DPYSL2 HDAC5 PCDHGB1 PPFIA1 LRRC4B GRIN2A N4BP3 PLEKHG5 TIAM1 SSH1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A UNC80

2.02e-0689115221GO:0030424
GeneOntologyCellularComponenttransporter complex

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B UNC80

2.69e-0655015216GO:1990351
GeneOntologyCellularComponentmultivesicular body lumen

PGA4 PGA5 PGA3

1.29e-0571523GO:0097486
GeneOntologyCellularComponentpresynaptic membrane

GABRB2 CACNA1C CACNA1D LRRC4B GRIN2A SCN1A SCN2A SCN8A SCN10A GRIN3B

3.65e-0527715210GO:0042734
GeneOntologyCellularComponentaxon initial segment

TRIM46 SCN1A SCN2A SCN8A

5.54e-05291524GO:0043194
GeneOntologyCellularComponentlate endosome lumen

PGA4 PGA5 PGA3

5.96e-05111523GO:0031906
GeneOntologyCellularComponentpresynapse

GABRB2 WHRN CACNA1C CACNA1D DPYSL2 ATR PPFIA1 LRRC4B GRIN2A PLEKHG5 S1PR5 SLC6A12 SCN1A SCN2A SCN8A SCN10A ATM GRIN3B

8.06e-0588615218GO:0098793
GeneOntologyCellularComponentendoplasmic reticulum-plasma membrane contact site

GRAMD1A C2CD2L GRAMD1C

1.02e-04131523GO:0140268
GeneOntologyCellularComponentplasma membrane protein complex

CACNA1C CACNA1D CACNA1F RAMP2 GRIN2A ITGA2B KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G GRIN3B

1.98e-0478515216GO:0098797
GeneOntologyCellularComponentsomatodendritic compartment

WHRN CACNA1C CACNA1D CACNA1F DPYSL2 JPH4 PPFIA1 GRIN2A KCNB2 N4BP3 DLGAP3 ARRB2 TIAM1 SCN1A SCN3A SCN8A CACNA1G GRIN3B BRD1 SAMD14 PDE11A

2.26e-04122815221GO:0036477
GeneOntologyCellularComponentsynaptic membrane

GABRB2 CACNA1C CACNA1D IQSEC3 LRRC4B GRIN2A ARRB2 TIAM1 SCN1A SCN2A SCN8A SCN10A GRIN3B

3.44e-0458315213GO:0097060
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CACNA1D CACNA1F CACNA1G

3.46e-04461524GO:0005891
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A SCN8A

3.92e-04201523GO:0033268
GeneOntologyCellularComponentmain axon

TRIM46 TIAM1 SCN1A SCN2A SCN8A

4.83e-04891525GO:0044304
GeneOntologyCellularComponentdendrite

WHRN CACNA1C CACNA1D DPYSL2 JPH4 PPFIA1 GRIN2A KCNB2 N4BP3 DLGAP3 ARRB2 TIAM1 SCN8A CACNA1G BRD1 SAMD14

5.27e-0485815216GO:0030425
GeneOntologyCellularComponentdendritic tree

WHRN CACNA1C CACNA1D DPYSL2 JPH4 PPFIA1 GRIN2A KCNB2 N4BP3 DLGAP3 ARRB2 TIAM1 SCN8A CACNA1G BRD1 SAMD14

5.41e-0486015216GO:0097447
GeneOntologyCellularComponentnon-motile cilium

WHRN CACNA1F GRK7 SSTR3 PTGS1 C1orf115 TIAM1

5.89e-041961527GO:0097730
GeneOntologyCellularComponentpostsynaptic specialization membrane

GABRB2 CACNA1C LRRC4B GRIN2A TIAM1 SCN8A GRIN3B

6.84e-042011527GO:0099634
GeneOntologyCellularComponentpostsynaptic density membrane

CACNA1C LRRC4B GRIN2A TIAM1 SCN8A GRIN3B

1.03e-031571526GO:0098839
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

BRPF1 BRD1

1.08e-0371522GO:0070776
GeneOntologyCellularComponentneuronal cell body

WHRN CACNA1C CACNA1D CACNA1F DPYSL2 KCNB2 DLGAP3 TIAM1 SCN1A SCN3A SCN8A CACNA1G GRIN3B BRD1 PDE11A

1.15e-0383515215GO:0043025
GeneOntologyCellularComponentpostsynaptic specialization

GABRB2 CACNA1C IQSEC3 DPYSL2 LRRC4B GRIN2A DLGAP3 TIAM1 SCN8A GRIN3B SAMD14

1.16e-0350315211GO:0099572
GeneOntologyCellularComponentH3 histone acetyltransferase complex

BRPF1 BRD1

1.43e-0381522GO:0070775
GeneOntologyCellularComponentpostsynaptic density

CACNA1C IQSEC3 DPYSL2 LRRC4B GRIN2A DLGAP3 TIAM1 SCN8A GRIN3B SAMD14

1.74e-0345115210GO:0014069
GeneOntologyCellularComponentNMDA selective glutamate receptor complex

GRIN2A GRIN3B

1.83e-0391522GO:0017146
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CACNA1D CACNA1F CACNA1G

1.98e-03731524GO:0034704
GeneOntologyCellularComponentpresynaptic active zone membrane

GABRB2 CACNA1D SCN8A GRIN3B

2.53e-03781524GO:0048787
GeneOntologyCellularComponentasymmetric synapse

CACNA1C IQSEC3 DPYSL2 LRRC4B GRIN2A DLGAP3 TIAM1 SCN8A GRIN3B SAMD14

2.62e-0347715210GO:0032279
GeneOntologyCellularComponentT-tubule

CACNA1C CACNA1D SCN1A SCN2A

2.65e-03791524GO:0030315
GeneOntologyCellularComponentpostsynaptic membrane

GABRB2 CACNA1C IQSEC3 LRRC4B GRIN2A ARRB2 TIAM1 SCN8A GRIN3B

2.90e-034051529GO:0045211
GeneOntologyCellularComponentpostsynapse

GABRB2 WHRN CACNA1C IQSEC3 DPYSL2 ATR PPFIA1 PSMC5 LRRC4B GRIN2A DLGAP3 ARRB2 TIAM1 SCN8A GRIN3B SAMD14

3.07e-03101815216GO:0098794
GeneOntologyCellularComponentcell body

WHRN CACNA1C CACNA1D CACNA1F DPYSL2 KCNB2 DLGAP3 TIAM1 SCN1A SCN3A SCN8A CACNA1G GRIN3B BRD1 PDE11A

3.22e-0392915215GO:0044297
GeneOntologyCellularComponentL-type voltage-gated calcium channel complex

CACNA1C CACNA1D

3.30e-03121522GO:1990454
GeneOntologyCellularComponentpresynaptic active zone

GABRB2 CACNA1D PPFIA1 SCN8A GRIN3B

3.73e-031411525GO:0048786
GeneOntologyCellularComponentendosome lumen

PGA4 PGA5 PGA3

3.76e-03431523GO:0031904
GeneOntologyCellularComponentcell-cell contact zone

OBSL1 TIAM1 SCN1A SCN2A

4.94e-03941524GO:0044291
GeneOntologyCellularComponentZ disc

CACNA1C CACNA1D OBSL1 SCN1A SCN8A

4.98e-031511525GO:0030018
GeneOntologyCellularComponentneuron to neuron synapse

CACNA1C IQSEC3 DPYSL2 LRRC4B GRIN2A DLGAP3 TIAM1 SCN8A GRIN3B SAMD14

5.00e-0352315210GO:0098984
GeneOntologyCellularComponent9+0 non-motile cilium

WHRN CACNA1F GRK7 PTGS1 C1orf115

5.26e-031531525GO:0097731
GeneOntologyCellularComponentperikaryon

CACNA1C CACNA1D CACNA1F KCNB2 BRD1 PDE11A

5.88e-032231526GO:0043204
HumanPhenoFocal hemiclonic seizure

GRIN2A SCN1A SCN2A SCN8A SCN9A

6.57e-0625575HP:0006813
HumanPhenoComplex febrile seizure

SCN1A SCN2A SCN8A SCN9A

2.32e-0516574HP:0011172
HumanPhenoObsessive-compulsive trait

ASH1L TIAM1 SCN1A SCN2A SCN9A

2.74e-0533575HP:0008770
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A SCN9A MAST3

3.01e-0517574HP:0032663
HumanPhenoGeneralized clonic seizure

GRIN2A SCN1A SCN2A SCN8A SCN9A

3.19e-0534575HP:0011169
HumanPhenoEyelid myoclonia seizure

SCN2A DHFR SCN8A

4.51e-057573HP:0032678
HumanPhenoNon-convulsive status epilepticus without coma

GRIN2A SCN1A SCN2A SCN9A

5.98e-0520574HP:0032671
HumanPhenoFocal impaired awareness seizure

CACNA1D GRIN2A SCN1A SCN2A SCN3A SCN8A SCN9A MAST3

6.70e-05126578HP:0002384
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A SCN9A

7.15e-058573HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A SCN9A

7.15e-058573HP:0200048
HumanPhenoFocal clonic seizure

GRIN2A SCN1A SCN2A SCN8A SCN9A

9.10e-0542575HP:0002266
HumanPhenoParesthesia

IL10 GRIN2A SCN1A SCN4A SCN9A SCN10A ATM SEMA4A

1.72e-04144578HP:0003401
HumanPhenoStatus epilepticus without prominent motor symptoms

GRIN2A SCN1A SCN2A SCN9A

2.04e-0427574HP:0031475
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A SCN8A

2.04e-0427574HP:0011171
HumanPhenoLimited neck range of motion

SCN1A SCN2A SCN9A

2.06e-0411573HP:0000466
HumanPhenoFocal aware seizure

GRIN2A SCN1A SCN2A SCN9A

2.36e-0428574HP:0002349
HumanPhenoClonic seizure

GRIN2A SCN1A SCN2A SCN3A SCN8A SCN9A

2.55e-0481576HP:0020221
HumanPhenoBilateral tonic-clonic seizure with focal onset

GRIN2A SCN1A SCN2A SCN8A MAST3

2.55e-0452575HP:0007334
HumanPhenoBilateral tonic-clonic seizure with generalized onset

GRIN2A SCN1A SCN2A SCN9A MAST3

2.55e-0452575HP:0025190
HumanPhenoStatus epilepticus with prominent motor symptoms

SCN1A SCN2A SCN9A MAST3

2.72e-0429574HP:0032658
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A SCN9A

2.72e-0412573HP:0012847
HumanPhenoFocal automatism seizure

SCN1A SCN2A SCN8A

2.72e-0412573HP:0032898
HumanPhenoHyperactivity

GABRB2 CACNA1C ATR ASH1L GATA4 PIDD1 GRIN2A TIAM1 ARVCF SCN1A SCN2A SCN3A SCN8A ATM SEMA4A SRRM2

2.74e-045585716HP:0000752
HumanPhenoEpileptic encephalopathy

GABRB2 GRIN2A SCN1A SCN2A SCN3A SCN8A MAST3

3.20e-04119577HP:0200134
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A SCN9A

3.51e-0413573HP:0007058
HumanPhenoPes valgus

CACNA1C SCN1A SCN2A SCN4A SCN9A

3.63e-0456575HP:0008081
HumanPhenoShort attention span

GABRB2 CACNA1C GATA4 PIDD1 GRIN2A TIAM1 ARVCF SCN1A SCN2A SCN3A SCN8A SCN9A ATM SEMA4A SRRM2

3.96e-045175715HP:0000736
HumanPhenoReduced attention regulation

GABRB2 CACNA1C GATA4 PIDD1 GRIN2A TIAM1 ARVCF SCN1A SCN2A SCN3A SCN8A SCN9A ATM SEMA4A SRRM2

4.77e-045265715HP:5200044
HumanPhenoAttention deficit hyperactivity disorder

GABRB2 CACNA1C GATA4 PIDD1 GRIN2A TIAM1 ARVCF SCN1A SCN3A SCN8A ATM SEMA4A SRRM2

4.86e-044135713HP:0007018
MousePhenoabnormal action potential

WHRN CACNA1D SCN1A SCN2A SCN8A SCN9A SCN10A CACNA1G

1.76e-051331198MP:0005402
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

2.42e-13101527IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

2.42e-13101527IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

2.42e-13101527PF06512
DomainChannel_four-helix_dom

CACNA1C CACNA1D CACNA1F SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

9.63e-135715211IPR027359
Domain-

CACNA1C CACNA1D CACNA1F SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

9.63e-1357152111.20.120.350
DomainIon_trans_dom

CACNA1C CACNA1D CACNA1F KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.47e-1011415212IPR005821
DomainIon_trans

CACNA1C CACNA1D CACNA1F KCNB2 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

1.47e-1011415212PF00520
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN8A SCN9A

1.99e-1061525PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN8A SCN9A

1.99e-1061525IPR024583
DomainSpy1

SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6

1.48e-08111525PF11357
DomainSpeedy

SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6

1.48e-08111525IPR020984
DomainIQ_motif_EF-hand-BS

IQSEC3 DCAF6 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

4.97e-08901529IPR000048
DomainIQ

IQSEC3 DCAF6 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

6.63e-08931529PS50096
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

5.29e-0731523IPR031688
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

5.29e-0731523PF16885
DomainVDCCAlpha1

CACNA1C CACNA1D CACNA1F CACNA1G

8.52e-07101524IPR002077
DomainIQ

IQSEC3 SCN1A SCN3A SCN4A SCN8A SCN9A SCN10A

1.77e-06711527PF00612
DomainVDCC_L_a1su

CACNA1C CACNA1D CACNA1F

2.10e-0641523IPR005446
DomainIQ

DCAF6 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A

4.32e-06811527SM00015
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

1.81e-0571523SM01062
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

1.81e-0571523PF08763
DomainVDCC_a1su_IQ

CACNA1C CACNA1D CACNA1F

1.81e-0571523IPR014873
DomainAspartic_peptidase_N

PGA4 PGA5 PGA3

1.81e-0571523IPR012848
DomainGPHH

CACNA1C CACNA1D CACNA1F

1.81e-0571523PF16905
DomainGPHH_dom

CACNA1C CACNA1D CACNA1F

1.81e-0571523IPR031649
DomainA1_Propeptide

PGA4 PGA5 PGA3

1.81e-0571523PF07966
DomainAspartic_peptidase_A1

PGA4 PGA5 PGA3

6.08e-05101523IPR001461
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

6.08e-05101523IPR033121
DomainAsp

PGA4 PGA5 PGA3

6.08e-05101523PF00026
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

6.08e-05101523PS51767
DomainTF_GATA_4/5/6

GATA4 GATA5

6.58e-0521522IPR016375
Domain-

PGA4 PGA5 PGA3

1.10e-041215232.40.70.10
DomainASP_PROTEASE

PGA4 PGA5 PGA3

1.10e-04121523PS00141
DomainAspartic_peptidase_AS

PGA4 PGA5 PGA3

1.42e-04131523IPR001969
DomainZinc_finger_PHD-type_CS

ASH1L DIDO1 PHF20L1 BRPF1 BRD1

1.86e-04651525IPR019786
DomainGATA_N

GATA4 GATA5

1.96e-0431522IPR008013
DomainDUF4782

GRAMD1A GRAMD1C

1.96e-0431522IPR031968
DomainVAST

GRAMD1A GRAMD1C

1.96e-0431522PS51778
DomainDUF4782

GRAMD1A GRAMD1C

1.96e-0431522PF16016
DomainGATA-N

GATA4 GATA5

1.96e-0431522PF05349
DomainBROMODOMAIN_1

ASH1L PBRM1 BRPF1 BRD1

2.26e-04371524PS00633
DomainBromodomain

ASH1L PBRM1 BRPF1 BRD1

2.51e-04381524PF00439
DomainGRAM

GRAMD1A SBF1 GRAMD1C

2.74e-04161523SM00568
DomainPeptidase_aspartic_dom

PGA4 PGA5 PGA3

3.30e-04171523IPR021109
DomainBROMODOMAIN_2

ASH1L PBRM1 BRPF1 BRD1

3.38e-04411524PS50014
DomainBromodomain

ASH1L PBRM1 BRPF1 BRD1

3.71e-04421524IPR001487
DomainBROMO

ASH1L PBRM1 BRPF1 BRD1

3.71e-04421524SM00297
Domain-

ASH1L PBRM1 BRPF1 BRD1

3.71e-044215241.20.920.10
DomainFATC

ATR ATM

6.47e-0451522PF02260
DomainGRAM

GRAMD1A SBF1 GRAMD1C

7.26e-04221523PF02893
DomainGRAM

GRAMD1A SBF1 GRAMD1C

7.26e-04221523IPR004182
DomainDUF3398

DOCK8 DOCK6

9.66e-0461522PF11878
DomainFAT

ATR ATM

9.66e-0461522PS51189
DomainFATC

ATR ATM

9.66e-0461522PS51190
DomainFAT

ATR ATM

9.66e-0461522PF02259
DomainPIK-rel_kinase_FAT

ATR ATM

9.66e-0461522IPR003151
DomainFATC_dom

ATR ATM

9.66e-0461522IPR003152
DomainDOCK_C/D_N

DOCK8 DOCK6

9.66e-0461522IPR021816
DomainPIK_FAT

ATR ATM

9.66e-0461522IPR014009
DomainFATC

ATR ATM

9.66e-0461522SM01343
DomainHR1_rho-bd

PPFIA1 PSMC5 PKN2

1.07e-03251523IPR011072
DomainZF_PHD_1

ASH1L DIDO1 PHF20L1 BRPF1 BRD1

1.13e-03961525PS01359
DomainBromodomain_CS

PBRM1 BRPF1 BRD1

1.20e-03261523IPR018359
DomainEPL1

BRPF1 BRD1

1.78e-0381522PF10513
DomainEnhancer_polycomb-like_N

BRPF1 BRD1

1.78e-0381522IPR019542
DomainDUSP

DUSP7 DUSP9 SSH1

2.01e-03311523IPR024950
DomainTYR_PHOSPHATASE_DUAL

DUSP7 DUSP9 SSH1

2.63e-03341523PS50054
DomainMKP

DUSP7 DUSP9

2.84e-03101522IPR008343
DomainDSPc

DUSP7 DUSP9 SSH1

2.86e-03351523SM00195
DomainTYR_PHOSPHATASE_DUAL_dom

DUSP7 DUSP9 SSH1

2.86e-03351523IPR020422
DomainBAH

ASH1L PBRM1

3.45e-03111522PS51038
DomainDHR-1_domain

DOCK8 DOCK6

3.45e-03111522IPR027007
DomainDHR_2

DOCK8 DOCK6

3.45e-03111522PS51651
DomainDHR_1

DOCK8 DOCK6

3.45e-03111522PS51650
DomainDHR-2

DOCK8 DOCK6

3.45e-03111522PF06920
DomainDOCK

DOCK8 DOCK6

3.45e-03111522IPR026791
DomainBAH_dom

ASH1L PBRM1

3.45e-03111522IPR001025
DomainPNMA

MOAP1 PNMA5

3.45e-03111522IPR026523
DomainBAH

ASH1L PBRM1

3.45e-03111522SM00439
DomainBAH

ASH1L PBRM1

3.45e-03111522PF01426
DomainDOCK_C

DOCK8 DOCK6

3.45e-03111522IPR010703
DomainDOCK-C2

DOCK8 DOCK6

3.45e-03111522PF14429
DomainDHR-2

DOCK8 DOCK6

3.45e-03111522IPR027357
DomainPNMA

MOAP1 PNMA5

3.45e-03111522PF14893
Domain-

TRIM46 ASH1L BARD1 DIDO1 ZFPL1 PHF20L1 BRPF1 BRD1 TRIM47 RNF139

3.77e-03449152103.30.40.10
DomainZnf_PHD-finger

ASH1L DIDO1 BRPF1 BRD1

3.95e-03791524IPR019787
DomainZnF_GATA

GATA4 GATA5

4.12e-03121522SM00401
DomainZnf_RING/FYVE/PHD

TRIM46 ASH1L BARD1 DIDO1 ZFPL1 PHF20L1 BRPF1 BRD1 TRIM47 RNF139

4.40e-0345915210IPR013083
DomainDual-sp_phosphatase_cat-dom

DUSP7 DUSP9 SSH1

4.49e-03411523IPR000340
DomainDSPc

DUSP7 DUSP9 SSH1

4.49e-03411523PF00782
DomainSAM_2

PPFIA1 SAMD11 SAMD14

5.14e-03431523PF07647
DomainTYR_PHOSPHATASE_dom

DUSP7 DUSP9 SBF1 SSH1

5.56e-03871524IPR000387
DomainMORN

JPH4 RSPH10B

5.62e-03141522SM00698
DomainuDENN

DENND1C SBF1

5.62e-03141522SM00800
DomainPHD

ASH1L DIDO1 BRPF1 BRD1

6.03e-03891524SM00249
DomainMORN

JPH4 RSPH10B

6.44e-03151522IPR003409
DomainuDENN

DENND1C SBF1

6.44e-03151522PF03456
DomainPI3/4_kinase_CS

ATR ATM

6.44e-03151522IPR018936
DomainZnf_GATA

GATA4 GATA5

6.44e-03151522IPR000679
DomainGATA

GATA4 GATA5

6.44e-03151522PF00320
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

CACNA1C SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

8.24e-11321088M27455
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

2.88e-09311087M877
PathwayREACTOME_L1CAM_INTERACTIONS

DPYSL2 ITGA2B SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

3.59e-071211089M872
PathwayREACTOME_CARDIAC_CONDUCTION

CACNA1C GATA4 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

6.61e-071301089M27454
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

CACNA1C CACNA1D DPYSL2 PSMC5 ITGA2B ABLIM3 TIAM1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G SEMA4A MAPK7

1.65e-0657510817M29853
PathwayREACTOME_MUSCLE_CONTRACTION

CACNA1C GATA4 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

3.49e-0620310810M5485
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

GABRB2 CACNA1C GRIN2A DLGAP3 SCN1A SCN2A DHFR SCN3A SCN4A SCN8A SCN9A SCN10A GRIN3B

4.50e-0636710813M48346
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F

8.60e-0661083M47762
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F CACNA1G

2.58e-05231084M47666
PathwayWP_RETT_SYNDROME

HDAC5 GRIN2A SCN1A SCN2A SCN8A

3.17e-05481085M39759
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1C CACNA1D CACNA1F CACNA1G

3.64e-05251084M47948
PathwayWP_DRAVET_SYNDROME

SCN1A SCN2A SCN3A SCN8A

5.79e-05281084M45519
PathwayWP_GASTRIC_ACID_PRODUCTION

PGA4 PGA5 PGA3

6.90e-05111083M39726
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1C CACNA1D CACNA1F

1.50e-04141083M47692
PathwayREACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE

ATR BARD1 RAD51AP1 ATM

3.19e-04431084M27588
PathwayWP_MAPK_SIGNALING

CACNA1C CACNA1D CACNA1F DUSP7 DUSP9 ARRB2 CACNA1G MAPK7

6.02e-042461088M39597
PathwayREACTOME_DISEASES_OF_DNA_REPAIR

ATR BARD1 RAD51AP1 ATM

6.17e-04511084M29854
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

1.49e-159162716382098
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN8A SCN9A SCN10A

9.30e-156162623652591
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN8A SCN9A SCN10A

1.55e-1113162615123669
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1C CACNA1D CACNA1F KCNB2 SCN1A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G

5.94e-111391621116985003
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A SCN4A SCN8A

2.56e-109162515746173
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A SCN8A

4.54e-104162417537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A SCN8A

4.54e-104162435031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A SCN8A

4.54e-104162429578003
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A SCN9A

2.26e-09516248812438
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN4A SCN8A

2.26e-095162417724025
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1C CACNA1D CACNA1F CACNA1G

1.57e-087162412900400
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE2 SPDYE5 SPDYE2B SPDYE6

5.61e-089162436272447
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A SCN9A

9.92e-083162319284629
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A SCN9A

9.92e-083162333895391
Pubmed

The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.

PGA4 PGA5 PGA3

9.92e-08316237926498
Pubmed

Crystal structure of human pepsinogen A.

PGA4 PGA5 PGA3

9.92e-08316239561228
Pubmed

The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.

PGA4 PGA5 PGA3

9.92e-083162321455714
Pubmed

Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.

PGA4 PGA5 PGA3

9.92e-083162319800305
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

9.92e-083162323859570
Pubmed

Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.

PGA4 PGA5 PGA3

9.92e-083162324170207
Pubmed

Relationships between the human pepsinogen DNA and protein polymorphisms.

PGA4 PGA5 PGA3

9.92e-08316233014868
Pubmed

The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.

PGA4 PGA5 PGA3

9.92e-08316232799289
Pubmed

CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.

PGA4 PGA5 PGA3

9.92e-083162319872561
Pubmed

Human pepsinogen A (PGA): an informative gene complex located at 11q13.

PGA4 PGA5 PGA3

9.92e-08316231968039
Pubmed

Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.

PGA4 PGA5 PGA3

9.92e-08316238053437
Pubmed

Family and population studies on the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

9.92e-08316232566575
Pubmed

Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.

PGA4 PGA5 PGA3

9.92e-08316232229438
Pubmed

Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.

PGA4 PGA5 PGA3

9.92e-083162325314140
Pubmed

Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.

PGA4 PGA5 PGA3

9.92e-083162319890696
Pubmed

Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.

PGA4 PGA5 PGA3

9.92e-08316238244094
Pubmed

Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.

PGA4 PGA5 PGA3

9.92e-083162321407214
Pubmed

Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.

PGA4 PGA5 PGA3

9.92e-08316236774973
Pubmed

Primary structure of human pepsinogen gene.

PGA4 PGA5 PGA3

9.92e-08316236300126
Pubmed

Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.

PGA4 PGA5 PGA3

9.92e-083162322304859
Pubmed

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.

PGA4 PGA5 PGA3

9.92e-083162324004680
Pubmed

Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.

PGA4 PGA5 PGA3

9.92e-08316238038355
Pubmed

Human pepsinogen A isozymogen patterns in serum and gastric mucosa.

PGA4 PGA5 PGA3

9.92e-08316232227273
Pubmed

Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.

PGA4 PGA5 PGA3

9.92e-083162323034090
Pubmed

A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.

PGA4 PGA5 PGA3

9.92e-083162324125879
Pubmed

Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.

PGA4 PGA5 PGA3

9.92e-08316238751234
Pubmed

Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.

PGA4 PGA5 PGA3

9.92e-08316233554488
Pubmed

Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.

PGA4 PGA5 PGA3

9.92e-083162323521833
Pubmed

Close linkage of human chromosomal pepsinogen A genes.

PGA4 PGA5 PGA3

9.92e-08316233017318
Pubmed

Serum pepsinogen test for early detection of gastric cancer in a European country.

PGA4 PGA5 PGA3

9.92e-083162321989121
Pubmed

Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.

PGA4 PGA5 PGA3

9.92e-08316239855083
Pubmed

Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.

PGA4 PGA5 PGA3

9.92e-08316239797498
Pubmed

The glomerular sieving of pepsinogen A and C in man.

PGA4 PGA5 PGA3

9.92e-08316232478370
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

9.92e-083162312610651
Pubmed

Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.

PGA4 PGA5 PGA3

9.92e-08316233815274
Pubmed

Pepsinogens: physiology, pharmacology pathophysiology and exercise.

PGA4 PGA5 PGA3

9.92e-083162310675278
Pubmed

Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.

PGA4 PGA5 PGA3

9.92e-08316233780036
Pubmed

Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.

PGA4 PGA5 PGA3

9.92e-08316232901984
Pubmed

Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.

PGA4 PGA5 PGA3

9.92e-08316233839486
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN9A SCN10A

9.92e-083162319699781
Pubmed

Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.

PGA4 PGA5 PGA3

9.92e-08316233467902
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

9.92e-083162318784617
Pubmed

The pepsinogens of human gastric mucosa.

PGA4 PGA5 PGA3

9.92e-08316234586732
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

9.92e-083162317544618
Pubmed

Genomic structure and evolution of the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

9.92e-08316232892778
Pubmed

The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.

PGA4 PGA5 PGA3

9.92e-083162324383519
Pubmed

Gene structures of pepsinogens A and C.

PGA4 PGA5 PGA3

9.92e-08316231455184
Pubmed

Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.

PGA4 PGA5 PGA3

9.92e-08316232831884
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

9.92e-083162332845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

9.92e-083162328518218
Pubmed

Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.

PGA4 PGA5 PGA3

9.92e-08316232032552
Pubmed

Analysis of the promoter of a human pepsinogen A gene.

PGA4 PGA5 PGA3

9.92e-08316231812762
Pubmed

O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.

PGA4 PGA5 PGA3

9.92e-08316237923573
Pubmed

Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.

PGA4 PGA5 PGA3

9.92e-08316239061458
Pubmed

Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.

PGA4 PGA5 PGA3

9.92e-083162312588289
Pubmed

Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.

PGA4 PGA5 PGA3

9.92e-083162323897256
Pubmed

An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.

PGA4 PGA5 PGA3

9.92e-083162311566730
Pubmed

The effect of acute and chronic protein loading on urinary pepsinogen A excretion.

PGA4 PGA5 PGA3

9.92e-08316231956484
Pubmed

Transcription regulation of human and porcine pepsinogen A.

PGA4 PGA5 PGA3

9.92e-08316238540382
Pubmed

Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.

PGA4 PGA5 PGA3

9.92e-083162322992016
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

9.92e-083162317928448
Pubmed

The role of serum pepsinogen in the detection of gastric cancer.

PGA4 PGA5 PGA3

9.92e-083162320981206
Pubmed

Gastric chief cell-specific transcription of the pepsinogen A gene.

PGA4 PGA5 PGA3

9.92e-08316238504820
Pubmed

Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.

PGA4 PGA5 PGA3

9.92e-083162321970995
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

9.92e-083162314973256
Pubmed

Serum pepsinogens in gastric cancer screening.

PGA4 PGA5 PGA3

9.92e-083162320428942
Pubmed

The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.

PGA4 PGA5 PGA3

9.92e-08316239525001
Pubmed

Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.

PGA4 PGA5 PGA3

9.92e-08316237886402
Pubmed

Serum pepsinogen and gastric cancer screening.

PGA4 PGA5 PGA3

9.92e-083162317379991
Pubmed

Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.

PGA4 PGA5 PGA3

9.92e-083162321547904
Pubmed

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

IL10 ATR ESRRA BARD1 DDB2 PTGIS PTGS1 DHFR ATM

1.15e-07170162919064572
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A SCN8A

2.18e-0712162430175250
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DCAF6 PPFIA1 ESRRA ASH1L GATA4 OBSL1 ZC3H3 FAM83H ZNF518A C2CD2L KIF20A CEP170 RAD51AP1 MALT1 PBRM1 SH3TC1 BRPF1 BRD1 SRRM2 UNC80

2.85e-0711161622031753913
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE2 SPDYE5 SPDYE2B SPDYE6

3.14e-0713162415611625
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1C CACNA1D CACNA1F

3.95e-074162320937870
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN9A SCN10A

3.95e-074162322260870
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

3.95e-074162335801810
Pubmed

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.

ATR DDB2 ATM

3.95e-074162323422745
Pubmed

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.

PGA4 PGA5 PGA3

3.95e-074162323047493
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

3.95e-074162321156207
Pubmed

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.

PGA4 PGA5 PGA3

3.95e-074162311915945
Pubmed

Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.

PGA4 PGA5 PGA3

3.95e-07416238322031
Pubmed

Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.

PGA4 PGA5 PGA3

3.95e-074162317136346
Pubmed

Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

PGA4 PGA5 PGA3

3.95e-074162312698190
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

3.95e-07416238974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

9.85e-07516231679748
InteractionCACNA1D interactions

CACNA1C CACNA1D JPH4 KCNB2 SCN1A SCN9A SCN10A

4.12e-10241547int:CACNA1D
InteractionSCN11A interactions

CACNA1C CACNA1D SCN1A SCN8A SCN9A SCN10A

8.54e-10151546int:SCN11A
InteractionSCN9A interactions

CACNA1C CACNA1D DPYSL2 SSTR3 SCN1A SCN9A

8.91e-09211546int:SCN9A
InteractionSCN1A interactions

CACNA1C CACNA1D SSTR3 SCN1A SCN9A SCN10A

7.42e-08291546int:SCN1A
InteractionSCN4B interactions

SSTR3 SCN1A SCN2A SCN8A

2.24e-0781544int:SCN4B
InteractionSCN5A interactions

CACNA1C CACNA1D SCN1A SCN8A SCN9A SCN10A

1.50e-06471546int:SCN5A
InteractionCACNA1B interactions

CACNA1C CACNA1D OBSL1 SCN1A SCN9A

8.74e-06371545int:CACNA1B
InteractionYWHAH interactions

TNK1 GAPVD1 PHACTR2 HDAC5 SPEG PPFIA1 N4BP3 PLEKHG5 FAM83H NUAK2 CEP170 ARRB2 SBF1 TIAM1 SSH1 SAMD11 NHS MAPK7 BRD1 SRRM2 DOCK6 MAST3

3.41e-05110215422int:YWHAH
InteractionCALML6 interactions

DCAF6 GRAMD1A BRD1

3.55e-0591543int:CALML6
InteractionCACNA1A interactions

CACNA1C CACNA1D SSTR3 MOAP1 SCN1A SCN9A SCN10A

4.49e-051231547int:CACNA1A
InteractionSCN10A interactions

CACNA1D SCN1A SCN10A

6.90e-05111543int:SCN10A
InteractionYWHAG interactions

TNK1 GAPVD1 PHACTR2 HDAC5 SPEG PPFIA1 GATA4 N4BP3 PLEKHG5 FAM83H C2CD2L CEP170 ARRB2 SBF1 TIAM1 SSH1 SAMD11 NHS PKN2 MAPK7 BRD1 SRRM2 MAST3

7.60e-05124815423int:YWHAG
InteractionYWHAE interactions

TNK1 GAPVD1 HDAC5 DOCK8 PPFIA1 OBSL1 ITGA2B N4BP3 PLEKHG5 FAM83H NUAK2 CEP170 DLGAP3 ARRB2 SBF1 TIAM1 SSH1 SAMD11 NHS MAPK7 BRD1 SRRM2 MAST3

8.37e-05125615423int:YWHAE
InteractionCACNA1C interactions

CACNA1C CACNA1D KCNB2 SCN1A SCN9A

1.03e-04611545int:CACNA1C
CytobandEnsembl 112 genes in cytogenetic band chr19p13

LINGO3 DENND1C S1PR5 YJU2B CSNK1G2-AS1 GRIN3B MED26 DOCK6 ATG4D MAST3 RAVER1

1.35e-0479716211chr19p13
Cytoband2q24

SCN3A SCN9A

6.67e-041116222q24
Cytoband1p36.31

NOL9 PLEKHG5

1.10e-031416221p36.31
Cytoband1q22

TRIM46 ASH1L SEMA4A

1.10e-035716231q22
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A SCN9A

1.10e-031271624chr2q24
Cytoband19p13.2

S1PR5 YJU2B DOCK6 ATG4D RAVER1

1.37e-03229162519p13.2
Cytoband2q24.3

SCN1A SCN2A

1.44e-031616222q24.3
Cytoband12p13.33

IQSEC3 B4GALNT3

2.03e-0319162212p13.33
CytobandEnsembl 112 genes in cytogenetic band chr1q22

TRIM46 ASH1L SEMA4A

2.07e-03711623chr1q22
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

5.26e-15910271203
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE2 SPDYE5 SPDYE2B SPDYE6

4.56e-07121024756
GeneFamilyCalcium voltage-gated channel subunits

CACNA1C CACNA1D CACNA1F CACNA1G

1.30e-05261024253
GeneFamilyPHD finger proteins

ASH1L DIDO1 PHF20L1 BRPF1 BRD1

1.56e-0490102588
GeneFamilyGlutamate ionotropic receptor NMDA type subunits

GRIN2A GRIN3B

6.50e-04710221201
GeneFamilyMAP kinase phosphatases

DUSP7 DUSP9

1.68e-03111022895
GeneFamilyParaneoplastic Ma antigens

MOAP1 PNMA5

1.68e-03111022671
GeneFamilyWD repeat domain containing|GRAM domain containing|BEACH domain containing

GRAMD1A GRAMD1C

2.36e-031310221146
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GATA4 GATA5

3.15e-0315102282
GeneFamilyImmunoglobulin like domain containing|Semaphorins

SEMA3B SEMA4A

5.60e-03201022736
GeneFamilyPWWP domain containing

BRPF1 BRD1

6.76e-032210221147
CoexpressionGSE7509_FCGRIIB_VS_TNFA_IL1B_IL6_PGE_STIM_DC_DN

WHRN MTHFSD GRAMD1A PLEKHG5 TIAM1 BRPF1 DOCK6 CCDC157

4.96e-061541608M6824
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB2 CACNA1C CACNA1D GRIN2A KCNB2 SCN2A SCN3A SCN8A UNC80

4.47e-081961629676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB2 CACNA1C CACNA1D GRIN2A SCN1A SCN2A SCN3A SCN8A UNC80

4.88e-081981629c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB2 CACNA1C CACNA1D GRIN2A SCN1A SCN2A SCN3A SCN8A UNC80

4.88e-0819816296d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB2 CACNA1C CACNA1D GRIN2A SCN1A SCN2A SCN3A SCN8A UNC80

4.88e-0819816294ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB2 CACNA1C CACNA1D GRIN2A KCNB2 SCN2A SCN3A SCN8A UNC80

4.88e-0819816290ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

GABRB2 CACNA1C CACNA1D GRIN2A KCNB2 SCN2A SCN3A SCN8A UNC80

5.32e-08200162948d801219bc771d6c7e151dc88ca4c179988de85
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C15orf62 WHRN DCAF6 SAMD11 CERCAM CACNA1G SAMD14

2.80e-06168162717fb9426eeea407b26fb895b8397faca95b7552d
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C15orf62 WHRN DCAF6 SAMD11 CERCAM CACNA1G SAMD14

2.80e-061681627a61b39884851384cffd430079040546d125b2b40
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM46 WHRN CENPT GRAMD1A OBSL1 DIPK1B ZSWIM9

3.40e-0617316272b448acd5e584f24567204c31b8d74715e92f32a
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM46 WHRN CENPT GRAMD1A OBSL1 DIPK1B ZSWIM9

3.40e-0617316275086edc29c5a6137ca09877929a1317f9739c801
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

GABRB2 MFSD6L C1orf115 SCN3A SCN9A UNC80 PDE11A

3.67e-06175162713b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

DIPK1B MFSD6L ITGA2B SERTAD4-AS1 RASIP1 SCN4A TRMT5

3.67e-06175162736cb3c8116bd467ee5da0630d8b3d3e4afcc2ded
ToppCellcritical-Epithelial-Ionocyte|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A TRIM47 PDE11A

5.10e-06184162758d36577eff814d46d72f031f3533d71549e3d6e
ToppCellE12.5-Endothelial|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAMP2 N4BP3 RASIP1 C1orf115 SH3TC1 ARHGAP27 TRIM47

5.67e-061871627b8ed57b3c39ffbf750cd08a3e03ec11dae43d00e
ToppCellcritical-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A TRIM47 PDE11A

6.29e-06190162705a2c3549b68f49081723bf35db14974274419d5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRB2 SCN1A SCN2A SCN8A CACNA1G SAMD14 UNC80

6.97e-0619316275fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_venous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

JPH4 RAMP2 ABLIM3 PTGIS C1orf115 TIAM1 SAMD14

8.24e-0619816276fd984da5d2c419aeb34c8cbd8a00440e2f820a5
ToppCell18-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

RAMP2 DIPK1B N4BP3 RASIP1 C1orf115 SH3TC1 DOCK6

8.24e-06198162770d3ea0837dd6ad62abdf349e566a2e62c8e345a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB2 CACNA1C GRIN2A SCN1A SCN2A SCN8A UNC80

8.24e-0619816278ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell18-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

RAMP2 DIPK1B N4BP3 RASIP1 C1orf115 SH3TC1 DOCK6

8.24e-0619816276b7f1b352dc3a803af87106ffb63944bd4286dfe
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)|Hippocampus / BrainAtlas - Mouse McCarroll V32

TNK1 PCDHGB1 C11orf42 DUSP9 PRR19

1.85e-05891625a707477b4aad91817ead162474e9a3c92326f60b
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr|Hippocampus / BrainAtlas - Mouse McCarroll V32

TNK1 PCDHGB1 C11orf42 DUSP9 PRR19

1.85e-058916251d2891e2ab271eae6ded2891208bd2bf37a17500
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P2|Hippocampus / BrainAtlas - Mouse McCarroll V32

TNK1 PCDHGB1 C11orf42 DUSP9 PRR19

1.85e-05891625e58b9da18cce5553e18f716c6637fedaaf4858fa
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

TNK1 PCDHGB1 C11orf42 DUSP9 PRR19

1.85e-058916254b807b23f0c315c8293a62278d48c67c9be25a1c
ToppCellCOVID-19_Severe-PLT_3|World / Disease Group and Platelet Clusters

CACNA1F ITGA2B FAM83H DLGAP3 PPP1R18 SAMD14

2.48e-051581626b981592129cd00564a7e44e6ed43fef4585f4700
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SERTAD4-AS1 ERI2 SCN8A CACNA1G SAMD14 GRAMD1C

2.66e-051601626636127753e3a22831f39d4c8170df40901e4329d
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SERTAD4-AS1 ERI2 SCN8A CACNA1G SAMD14 GRAMD1C

2.66e-051601626cb8d0dc1a6c69c7a85c5fdd8f0f6cca1b73dfc63
ToppCellLA-12._Cytoplasmic_Cardiomyocyte_II|World / Chamber and Cluster_Paper

RAMP2 RFX6 DCLRE1B SCN2A SCN10A

3.10e-05991625aed68765f60e54b7e2406c5f09fa744fcd844354
ToppCellcontrol-Epithelial-Ionocyte|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GABRB2 MFSD6L C1orf115 SCN9A DOCK6 PDE11A

3.17e-0516516265cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GABRB2 MFSD6L C1orf115 SCN9A DOCK6 PDE11A

3.28e-0516616266d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCellLA-12._Cytoplasmic_Cardiomyocyte_II|LA / Chamber and Cluster_Paper

RAMP2 RFX6 DCLRE1B SCN2A SCN10A

3.75e-051031625e457f25e65a62c94685b15cd73fd3278fb94bf9c
ToppCell343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CACNA1D DIPK1B ITGA2B PTGS1 DHFR AFG1L

3.87e-0517116264ccd88cf812dd8bfdc55159c6f504e9c84e4f4fc
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DIDO1 PPP1R13L ZC3H3 RAD51AP1 SCN1A CCDC157

4.00e-051721626d65ffff3e341af34a043a0d802d7ba4b69de36e9
ToppCellE12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAMP2 N4BP3 RASIP1 C1orf115 SH3TC1 ARHGAP27

4.00e-051721626ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCellE12.5-Endothelial-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAMP2 N4BP3 RASIP1 C1orf115 SH3TC1 ARHGAP27

4.00e-0517216262136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCellBronchial_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

GABRB2 MFSD6L C1orf115 SCN3A SCN9A PDE11A

4.13e-051731626e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

GABRB2 MFSD6L C1orf115 SCN3A SCN9A PDE11A

4.26e-0517416267e7b13de916cd4fa0fa6fb06e6b4942877afa9fb
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 GATA5 N4BP3 PTGIS RASIP1 TCF23

4.54e-051761626c4d9166e5bbb7ca544107db14e4374289f5de6bd
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 GATA5 N4BP3 PTGIS RASIP1 TCF23

4.54e-051761626d58ef51002ea50b3037636038214bbb7454cb503
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A PDE11A

4.69e-05177162699500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAMP2 ITGA2B ABLIM3 PTGS1 SH3TC1 UBAP1L

4.84e-0517816264ef6344d0ffc9c55b1240bee94b741382f1427bb
ToppCell390C-Endothelial_cells-Endothelial-E-|390C / Donor, Lineage, Cell class and subclass (all cells)

RAMP2 DIPK1B PLEKHG5 RASIP1 UBAP1L DOCK6

4.84e-051781626804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAMP2 ITGA2B ABLIM3 PTGS1 SH3TC1 UBAP1L

4.84e-051781626c65932cbedbbfacb6f0299280663fe7c88dba72b
ToppCell390C-Endothelial_cells-Endothelial-E|390C / Donor, Lineage, Cell class and subclass (all cells)

RAMP2 DIPK1B PLEKHG5 RASIP1 UBAP1L DOCK6

4.84e-051781626ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WHRN HDAC5 BARD1 STMND1 ABLIM3 C1orf115

4.99e-051791626dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A PDE11A

5.15e-0518016268af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg|bone_marrow / Manually curated celltypes from each tissue

GABRB2 DIPK1B GATA5 ITGA2B PTGS1 SAMD14

5.15e-05180162644ba37bead1ac39bce4d3eef00961063c50ced0d
ToppCellInfluenza_Severe-Platelet|Influenza_Severe / Disease group and Cell class

CENPT DIPK1B ITGA2B ABLIM3 PTGS1 SAMD14

5.31e-0518116264d037b098bb6f780ed8b15c0ec23a6f4d86bf45a
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESPNL BARD1 KIF20A RAD51AP1 DHFR PDE11A

5.31e-051811626e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHACTR2 RAMP2 PTGIS PTGS1 RASIP1 ARRB2

5.47e-051821626000ff26c51c6a1ea8770c02722523e55be83b46f
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

RFX6 KCNB2 SCN2A SCN3A SCN8A UNC80

5.47e-05182162657bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

RAMP2 PLEKHG5 RASIP1 C1orf115 SH3TC1 ARHGAP27

5.47e-051821626fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCellfacs-Liver-Liver_non-hepato/SCs_st|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHACTR2 RAMP2 PTGIS PTGS1 RASIP1 ARRB2

5.47e-051821626b906e6e584ecbe92d3030bbdc4426f244fbe0045
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A PDE11A

5.64e-051831626ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GABRB2 MFSD6L C1orf115 SCN9A TRIM47 PDE11A

5.81e-051841626a60802e11dcc5f932811260b08a95a32f60f6b19
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GABRB2 MFSD6L C1orf115 SCN9A TRIM47 PDE11A

5.81e-05184162639c230d32e4259bc784e0edfd9e2884c96898564
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JPH4 LRRC4B RFX6 KCNB2 SCN3A UNC80

5.81e-0518416263da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GABRB2 MFSD6L C1orf115 SCN9A TRIM47 PDE11A

5.81e-0518416262a2fb691cc9414ef5b06c26239d2da03d6d7e5c2
ToppCellE12.5-Endothelial-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAMP2 N4BP3 RASIP1 SH3TC1 ARHGAP27 TRIM47

5.99e-051851626e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCellE12.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAMP2 N4BP3 RASIP1 SH3TC1 ARHGAP27 TRIM47

5.99e-0518516260bccc424d0466f7f82baa00127c733640a2d50fb
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CENPT PPP1R13L PTGIS S1PR5 BRPF1 TRMT5

5.99e-051851626daea170d827226dda6750bf1838ffd82f070c4d4
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RFX6 KCNB2 SCN2A SCN3A SCN8A UNC80

6.17e-051861626b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GABRB2 SERTAD4-AS1 PTGIS NHS CACNA1G UNC80

6.36e-0518716265258674d0346e5c51a4b965efcdc1790c970845d
ToppCellfacs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHACTR2 CENPT RAMP2 PTGS1 C1orf115 TRIM47

6.36e-051871626d9943e65eedab73d141eae524e2411653a751705
ToppCellfacs-Heart-LA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHACTR2 CENPT RAMP2 PTGS1 C1orf115 TRIM47

6.36e-0518716267b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCellmoderate-Epithelial-Ionocyte|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A PDE11A

6.36e-0518716263e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCelldroplet-Fat-SCAT-30m-Endothelial-Cd36+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 ABLIM3 RASIP1 C1orf115 SCN3A DOCK6

6.55e-051881626e901a9bdf00b8e91806f445af66647373bf62661
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GABRB2 MFSD6L KCNB2 SCN3A SCN9A PDE11A

6.55e-0518816261f912ea015f50570e848259d948a0ba682d64bb4
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GATA4 GRIN2A SSTR3 PTGIS PTGS1 SEMA3B

6.55e-0518816269655a4c47b644a870017d349b99063e17dbae572
ToppCelldroplet-Fat-SCAT-30m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 ABLIM3 RASIP1 C1orf115 SCN3A DOCK6

6.55e-0518816265cf060bb8adaefa9964187195d67993c1248ef47
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RFX6 KCNB2 SCN2A SCN3A SCN8A UNC80

6.55e-051881626c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCelldroplet-Fat-SCAT-30m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 ABLIM3 RASIP1 C1orf115 SCN3A DOCK6

6.55e-051881626449f9602df3c83b2110eb479a00d428d1b55b423
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A PDE11A

6.74e-0518916266011b747e27d61d222380a7bffdd921a68e9b657
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRB2 SCN1A SCN2A SCN8A SAMD14 UNC80

6.74e-051891626f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 N4BP3 ABLIM3 RASIP1 C1orf115 DOCK6

6.94e-051901626c8370c922e0cf0e0c36e02e1ed2b4053ad6a8073
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

GABRB2 SERTAD4-AS1 ABLIM3 SCN2A SCN3A SCN9A

6.94e-0519016266e92c78799f34b31d098854503c796edb0dc7f80
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 N4BP3 ABLIM3 RASIP1 C1orf115 DOCK6

6.94e-0519016265174f91a880f85bb20806023aa68bd4b8ca24ea5
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP2 N4BP3 ABLIM3 RASIP1 C1orf115 DOCK6

6.94e-05190162690e494cbfbed33a3a0d29bb7dae83f0c81580bcf
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GABRB2 RAMP2 MFSD6L C1orf115 SCN9A PDE11A

7.15e-0519116268f4637e801554e2343b974fe7794f01dd2151418
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

JPH4 RFX6 KCNB2 SCN2A SCN3A SCN9A

7.15e-05191162676311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCellfacs-Heart-RV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHACTR2 RAMP2 PTGS1 RASIP1 H1-8 TRIM47

7.15e-051911626f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHACTR2 RAMP2 PTGS1 RASIP1 H1-8 TRIM47

7.15e-051911626e518c598719119e60c76016c586b1520c258bbcb
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

IQSEC3 GRIN2A KCNB2 SCN2A SCN8A UNC80

7.35e-0519216264c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAMP2 DIPK1B N4BP3 RASIP1 C1orf115 DOCK6

7.35e-0519216261f35efb0765e05f7f9c881849953bef3965be25a
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 GRIN2A KCNB2 SCN2A SCN3A UNC80

7.57e-051931626461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 GRIN2A KCNB2 SCN2A SCN3A UNC80

7.57e-0519316260dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IQSEC3 RAMP2 ITGA2B N4BP3 ABLIM3 RASIP1

7.57e-051931626bd0027fa97de41ae22ff64a61c8e217496f122ca
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NLRX1 MFSD6L KCNB2 SCN2A SCN3A PDE11A

7.79e-051941626d024cd75a97f048257e49cee9190fb2e79202ee2
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GABRB2 RFX6 KCNB2 SCN2A TRIM47 UNC80

7.79e-0519416262dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D ASH1L RFX6 ZC3H3 SRRM2 UNC80

8.01e-0519516263e519cffa6144a62b06124642a14c9ff39b76554
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB2 PHACTR2 GRIN2A C1orf115 SCN1A SCN2A

8.01e-051951626787e95fb59c40bba784544b662fac37606ae1427
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D ASH1L RFX6 ZC3H3 SRRM2 UNC80

8.01e-0519516267796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GABRB2 MFSD6L N4BP3 C1orf115 SCN9A PDE11A

8.24e-051961626ef650ff106a76c1e926e13c7f002fbc452cc48ae
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

JPH4 RFX6 KCNB2 SCN2A SCN3A UNC80

8.24e-0519616264bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCellStriatum-Neuronal-Excitatory|Striatum / BrainAtlas - Mouse McCarroll V32

DCAF6 JPH4 GRIN2A SCN2A SCN3A MAST3

8.24e-05196162667400193ba469cf4d939e94f5ed94995e384bc07
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RFX6 KCNB2 SCN2A SCN3A SCN8A UNC80

8.71e-0519816268f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM46 CACNA1C SPEG GRIN2A KCNB2 ARVCF

8.71e-0519816261e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RFX6 KCNB2 SCN2A SCN3A SCN8A UNC80

8.71e-051981626e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-Venous_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

JPH4 RAMP2 DIPK1B PTGIS RASIP1 C1orf115

8.96e-05199162670e05d7c0c68c28754ce0e72434b205aed6287ae
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPYSL2 RAMP2 DUSP7 GATA5 PTGIS TIAM1

8.96e-0519916265d976d57872a8a25a11fe8cd53b01aa21a1a519a
Druglamotrigine

CACNA1C CACNA1D CACNA1F GRIN2A PTGS1 SCN2A SCN3A SCN4A SCN9A SCN10A CACNA1G GRIN3B

3.26e-1111615912CID000003878
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN4A SCN8A SCN10A

9.30e-1161595ctd:C475726
DrugZonisamide

SCN1A SCN2A SCN3A SCN4A SCN9A CACNA1G

1.23e-09171596DB00909
Druggabapentin

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A SCN3A SCN4A SCN9A SCN10A CACNA1G GRIN3B

3.04e-0816915911CID000003446
Drugriluzole

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A SCN3A SCN4A SCN9A SCN10A CACNA1G GRIN3B

4.11e-0817415911CID000005070
DrugNSC7524

CACNA1C CACNA1D CACNA1F GRIN2A SCN2A SCN3A SCN4A SCN9A SCN10A CACNA1G GRIN3B

6.52e-0818215911CID000005657
Drugprocaine

GABRB2 CACNA1C CACNA1D CACNA1F SCN3A SCN4A SCN9A SCN10A CACNA1G PKN2

1.27e-0715315910CID000004914
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN8A SCN10A

1.57e-0781594ctd:C489827
Drugbepridil

CACNA1C CACNA1D CACNA1F SBF1 SCN3A SCN4A SCN9A SCN10A CACNA1G

2.58e-071261599CID000002351
DrugCinnarizine

CACNA1C CACNA1D CACNA1F CACNA1G

2.81e-0791594DB00568
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN4A SCN9A

3.34e-0731593ctd:C561228
Drugisradipine

CACNA1C CACNA1D CACNA1F SCN3A SCN4A SCN9A SCN10A CACNA1G

5.12e-071001598CID000003784
DrugMibefradil

CACNA1C CACNA1D CACNA1F CACNA1G

7.27e-07111594DB01388
DrugIpratropium bromide [22254-24-6]; Up 200; 9.8uM; MCF7; HT_HG-U133A

WHRN HDAC5 DUSP9 ITGA2B ZFPL1 ARVCF SCN10A SEMA4A DOCK6 MAST3

1.25e-06196159102762_UP
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A SCN10A

1.33e-0641593ctd:C501880
DrugPropofol

GABRB2 SCN2A SCN4A

1.33e-0641593DB00818
DrugFospropofol

GABRB2 SCN2A SCN4A

1.33e-0641593DB06716
Drugtetradotoxin

GABRB2 CACNA1C CACNA1D GRIN2A PTGS1 SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A CACNA1G PKN2 GRIN3B

1.97e-0642815914CID000020382
DrugVerapamil

CACNA1C CACNA1D CACNA1F CACNA1G

3.90e-06161594DB00661
Drugbenzocaine

SCN2A SCN3A SCN4A SCN9A SCN10A

5.67e-06371595CID000002337
DrugScorpion Venoms

SCN2A SCN3A SCN4A SCN9A

6.49e-06181594ctd:D012604
Drugfenpropathrin

SCN2A SCN3A SCN10A

6.58e-0661593ctd:C044267
Drugdiprafenone

SCN3A SCN4A SCN9A SCN10A

8.18e-06191594CID000071249
DrugTetrodotoxin

GRIN2A SCN2A SCN3A SCN8A SCN9A

8.42e-06401595ctd:D013779
Drugpyraclofos

CACNA1C CACNA1D KCNB2 SCN2A SCN4A SCN9A CACNA1G

9.69e-061061597CID000093460
DrugDigoxigenin [1672-46-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A

GABRB2 SPEG DUSP7 N4BP3 PTGIS SH3TC1 ARVCF SEMA4A DOCK6

1.01e-0519615993397_DN
DrugT2755

GRIN2A SCN3A SCN4A SCN9A SCN10A GRIN3B

1.04e-05711596CID000005514
Drugdiphenhydramine

PTGS1 SCN3A SCN4A SCN9A SCN10A ATM

1.43e-05751596CID000003100
Drug3alpha5betaHS

GRIN2A FDXR GRIN3B

1.82e-0581593CID000165024
Drugphenytoin

CACNA1C CACNA1D CACNA1F SCN2A SCN3A SCN4A SCN9A SCN10A CACNA1G

2.44e-052191599CID000001775
DrugAC1NT1AF

SCN3A SCN4A SCN9A SCN10A

2.58e-05251594CID005322157
DrugNimodipine

CACNA1C CACNA1D CACNA1F

2.72e-0591593DB00393
Drugbupivacaine

PTGIS PTGS1 SCN3A SCN4A SCN9A SCN10A PKN2

2.84e-051251597CID000002474
DrugPirmenolum

SCN3A SCN4A SCN9A SCN10A

3.04e-05261594CID000004853
Drugtoluene

GRIN2A FDXR SCN3A SCN4A SCN9A SCN10A PKN2 GRIN3B

3.28e-051751598CID000001140
DrugPbTx-1

SCN3A SCN4A SCN9A SCN10A

3.55e-05271594CID006437089
DrugAC1L1MOZ

SCN3A SCN4A SCN9A SCN10A

3.55e-05271594CID000031958
Drugnefopam

SCN3A SCN4A SCN9A SCN10A

3.55e-05271594CID000004450
Drugparaben

SCN3A SCN4A SCN9A SCN10A

4.11e-05281594CID000007175
Drugmu-conotoxin KIIIA, Conus kinoshitai

SCN2A SCN4A

4.85e-0521592ctd:C502265
DrugQ_AB

CEP170 DHFR

4.85e-0521592CID000115349
DrugFenbendazole [43210-67-9]; Up 200; 13.4uM; PC3; HT_HG-U133A

CACNA1D ITGA2B ZFPL1 NUAK2 SH3TC1 CACNA1G DOCK6 GRAMD1C

4.87e-0518515984542_UP
Drugo-difluorobenzene

GRIN2A SCN2A GRIN3B

5.29e-05111593CID000009706
Drugtriamterene

DHFR SCN3A SCN4A SCN9A SCN10A

5.30e-05581595CID000005546
Drugtocainide

SCN3A SCN4A SCN9A SCN10A

5.45e-05301594CID000038945
Drugpropofol

GABRB2 IL10 GRIN2A SCN3A SCN4A SCN9A SCN10A GRIN3B

6.10e-051911598CID000004943
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A

GABRB2 NOL6 PTGS1 C2CD2L MALT1 ARVCF CACNA1G MAPKBP1

6.56e-0519315985602_DN
DrugDirithromycin [62013-04-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A

GABRB2 TNK1 ESRRA NLRX1 ZC3H3 SBF1 ARVCF DOCK6

6.80e-0519415982863_DN
DrugNSC93767

SCN3A SCN4A SCN9A SCN10A

7.07e-05321594CID000005658
Drugremifentanil

CACNA1C CACNA1D GRIN2A GRIN3B

7.07e-05321594CID000060814
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A

ZC3H3 PTGS1 C2CD2L MALT1 SBF1 ARVCF SEMA3B ATM

7.31e-0519615985569_DN
DrugMafenide hydrochloride [138-37-4]; Down 200; 18uM; PC3; HT_HG-U133A

TNK1 NLRX1 ZFPL1 SBF1 FDXR SCN8A MAPK7 DOCK6

7.31e-0519615985079_DN
DrugPiretanide [55837-27-9]; Up 200; 11uM; PC3; HT_HG-U133A

ITGA2B ARVCF SCN2A SCN4A PKN2 ATM SEMA4A MAPK7

7.31e-0519615984490_UP
Drugnimodipine

GABRB2 CACNA1C CACNA1D CACNA1F GRIN2A CACNA1G GRIN3B

7.32e-051451597CID000004497
DrugDantrolene-13C3

IL10 CACNA1C CACNA1D CACNA1F GRIN2A CACNA1G GRIN3B

7.32e-051451597CID000002951
Drugzonisamide

SCN3A SCN4A SCN9A SCN10A CACNA1G

7.32e-05621595CID000005734
DrugTrifluridine [70-00-8]; Down 200; 13.6uM; PC3; HT_HG-U133A

WHRN TNK1 TNFRSF6B C2CD2L KIF20A TIAM1 ATM MAST3

7.58e-0519715985819_DN
DrugAjmaline [4360-12-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A

TNK1 ESRRA GATA4 ABLIM3 ZFPL1 SBF1 ARVCF MAST3

7.58e-0519715982899_DN
Drughaloperidol; Up 200; 10uM; MCF7; HT_HG-U133A

TNK1 NUAK2 MALT1 ARRB2 SBF1 SEMA3B MAPKBP1 MAPK7

7.58e-0519715987003_UP
DrugKhellin [82-02-0]; Down 200; 15.4uM; MCF7; HT_HG-U133A

GABRB2 MTHFSD ESRRA ASH1L SBF1 ARVCF ATM MAPK7

7.58e-0519715981504_DN
DrugDienestrol [84-17-3]; Down 200; 15uM; PC3; HT_HG-U133A

HDAC5 PIDD1 NUAK2 SBF1 SCN9A MAPK7 DOCK6 GRAMD1C

7.85e-0519815985727_DN
DrugCNS 1145

CACNA1C CACNA1D CACNA1F CACNA1G

8.00e-05331594CID000190902
DrugIHC-64

CACNA1C CACNA1D CACNA1F CACNA1G

8.00e-05331594CID000162753
DrugVerapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; MCF7; HT_HG-U133A

HDAC5 NLRX1 NOL6 PIDD1 MALT1 SEMA3B MAPK7 DOCK6

8.13e-0519915981509_DN
DrugDisopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A

WHRN CENPT PIDD1 C2CD2L SBF1 FDXR SRRM2 MAST3

8.13e-0519915987439_UP
DrugHydrocotarnine hydrobromide [5985-00-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A

ESRRA TNFRSF6B PIDD1 ITGA2B ARVCF SEMA3B SEMA4A DOCK6

8.13e-0519915982765_UP
DrugAC1NPPZW

CACNA1C CACNA1D SPEG SCN2A SCN4A SCN9A

8.63e-051031596CID005183170
Drug4-AP

GABRB2 CACNA1C CACNA1D GRIN2A KCNB2 PTGS1 SCN4A SCN9A GRIN3B

8.70e-052581599CID000001727
Drug5-hydroxypropafenone

SCN3A SCN4A SCN9A SCN10A

9.02e-05341594CID000107927
Drugsaxitoxin

SCN2A SCN3A SCN4A SCN9A SCN10A

9.19e-05651595CID000037165
Drugloperamide

CACNA1C CACNA1D CACNA1F GRIN2A CACNA1G PKN2

9.61e-051051596CID000003954
Drugaldosterone

CACNA1C CACNA1D CACNA1F PTGS1 FDXR SCN4A SCN9A CACNA1G PKN2 MAPK7 PDE11A

1.14e-0439715911CID000005839
DrugAC1L2AC7

CACNA1C CACNA1D CACNA1F LRRC4B CACNA1G

1.22e-04691595CID000068733
Drugaprindine

SCN3A SCN4A SCN9A SCN10A

1.40e-04381594CID000002218
DrugCeftazidime

IL10 DHFR

1.45e-0431592ctd:D002442
DrugPhenylbutazone

PTGIS PTGS1

1.45e-0431592DB00812
Drugbruceine D

PTGS1 DHFR

1.45e-0431592CID000122784
DrugCAS 298-57-7

CACNA1C CACNA1D CACNA1F PTGIS CACNA1G

1.60e-04731595CID000002761
DrugS-ropivacaine

SCN3A SCN4A SCN9A SCN10A

1.72e-04401594CID000071273
DrugAC1L1DME

IL10 GRIN2A MALT1 GRIN3B MAPK7

1.82e-04751595CID000002414
Drugpentobarbital

GABRB2 GRIN2A SCN3A SCN4A SCN9A SCN10A PKN2 GRIN3B

1.84e-042241598CID000004737
DrugAC1L1GTT

CACNA1C CACNA1D HDAC5 GRIN2A TIAM1 SCN4A GRIN3B MAPK7

2.40e-042331598CID000003837
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

1.09e-14101547DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

1.09e-14101547DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

7.12e-14121547DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

GRIN2A SBF1 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SCN10A

2.05e-071631549DOID:1826 (implicated_via_orthology)
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

5.56e-0741543DOID:0060173 (implicated_via_orthology)
DiseaseBipolar Disorder

GABRB2 WHRN CACNA1C CACNA1D DPYSL2 HDAC5 GRIN2A ARRB2 PBRM1 SCN2A SCN8A BRD1 AFG1L

1.45e-0647715413C0005586
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

4.85e-06221544DOID:2030 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

GABRB2 DOCK8 ASH1L SCN1A SCN2A SCN8A

9.61e-06931546C1535926
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A SCN9A

1.14e-0591543C3502809
DiseaseEpilepsy

GABRB2 GRIN2A SCN1A SCN2A SCN8A SCN9A

2.38e-051091546C0014544
Diseaseataxia telangiectasia (implicated_via_orthology)

ATR ATM

2.71e-0521542DOID:12704 (implicated_via_orthology)
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

2.71e-0521542C4551549
DiseaseManic Disorder

CACNA1C CACNA1D HDAC5 GRIN2A SCN2A

3.58e-05711545C0024713
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A SCN9A

3.84e-05131543C0751122
DiseaseManic

CACNA1C CACNA1D HDAC5 GRIN2A SCN2A

5.64e-05781545C0338831
DiseaseDepression, Bipolar

CACNA1C CACNA1D HDAC5 GRIN2A SCN2A

5.99e-05791545C0005587
DiseaseEpilepsy, Cryptogenic

GABRB2 GRIN2A SCN1A SCN2A SCN8A

7.16e-05821545C0086237
DiseaseAwakening Epilepsy

GABRB2 GRIN2A SCN1A SCN2A SCN8A

7.16e-05821545C0751111
DiseaseAura

GABRB2 GRIN2A SCN1A SCN2A SCN8A

7.16e-05821545C0236018
DiseaseB Virus Infection

SCN8A SCN9A

8.09e-0531542C0037140
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

8.09e-0531542cv:C5575231
DiseasePostherpetic neuralgia

SCN8A SCN9A

8.09e-0531542C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

8.09e-0531542C0019372
DiseasePrimary Erythermalgia

SCN9A SCN10A

8.09e-0531542C0014805
DiseasePAROXYSMAL EXTREME PAIN DISORDER

SCN9A SCN10A

8.09e-0531542C1833661
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

IL10 SCN1A SCN2A

1.07e-04181543HP_0002373
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

BARD1 ATM SEMA4A

1.27e-04191543C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

BARD1 ATM SEMA4A

1.27e-04191543C2936783
DiseaseHeart Block

CACNA1D SCN10A

1.61e-0441542C0018794
DiseaseAuriculo-Ventricular Dissociation

CACNA1D SCN10A

1.61e-0441542C0004331
DiseaseICAM-1 measurement

S1PR5 ATG4D RAVER1

2.60e-04241543EFO_0004520
DiseaseMood Disorders

GABRB2 CACNA1C CACNA1D GRIN2A SSTR3 ARRB2

2.61e-041681546C0525045
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

BARD1 ATM SEMA4A

3.32e-04261543C0009405
DiseaseHereditary non-polyposis colorectal cancer syndrome

BARD1 ATM SEMA4A

3.72e-04271543C1112155
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

4.00e-0461542C0220669
DiseaseHereditary Nonpolyposis Colorectal Cancer

BARD1 ATM SEMA4A

4.61e-04291543C1333990
DiseaseSeckel syndrome (implicated_via_orthology)

CENPT ATR

5.59e-0471542DOID:0050569 (implicated_via_orthology)
DiseaseRENAL CELL CARCINOMA, NONPAPILLARY

PBRM1 RNF139

5.59e-0471542144700
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

5.59e-0471542C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

5.59e-0471542C0751057
DiseaseCongenital Pain Insensitivity

SCN9A SCN10A

5.59e-0471542C0002768
DiseaseNonpapillary renal cell carcinoma

PBRM1 RNF139

5.59e-0471542cv:CN074294
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

SCN9A SCN10A

5.59e-0471542C0020075
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

7.42e-0481542C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

7.42e-0481542C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

7.42e-0481542C0338479
Diseaseadult respiratory distress syndrome (biomarker_via_orthology)

IL10 RAMP2

7.42e-0481542DOID:11394 (biomarker_via_orthology)
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

7.42e-0481542C0751120
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

7.42e-0481542C0438414
DiseaseSudden Cardiac Death

CACNA1C PPP1R13L

7.42e-0481542C0085298
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

7.42e-0481542C0393703
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

8.77e-04361543DOID:11723 (implicated_via_orthology)
DiseaseFebrile Convulsions

SCN1A SCN2A

9.51e-0491542C0009952
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

9.51e-0491542C0014550
DiseaseAllodynia

IL10 PTGS1 SCN10A MAPK7

9.96e-04841544C0458247
DiseaseMechanical Allodynia

IL10 PTGS1 SCN10A MAPK7

9.96e-04841544C2936719
DiseaseHyperalgesia, Secondary

IL10 PTGS1 SCN10A MAPK7

9.96e-04841544C0751212
DiseaseHyperalgesia, Primary

IL10 PTGS1 SCN10A MAPK7

9.96e-04841544C0751211
DiseaseHyperalgesia, Thermal

IL10 PTGS1 SCN10A MAPK7

9.96e-04841544C0751214
DiseaseTactile Allodynia

IL10 PTGS1 SCN10A MAPK7

9.96e-04841544C0751213
DiseaseHyperalgesia

IL10 PTGS1 SCN10A MAPK7

9.96e-04841544C0020429
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

1.18e-03101542C0917800
DiseaseShortened QT interval

CACNA1C SCN10A

1.44e-03111542C0151879
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

1.44e-03111542C0393702
Diseasenasopharynx carcinoma (is_marker_for)

ATR GRIN2A ATM

1.48e-03431543DOID:9261 (is_marker_for)
DiseaseNeuroblastoma

DOCK8 BARD1 SEMA3B

1.91e-03471543C0027819
Diseasetetralogy of Fallot (is_implicated_in)

GATA4 GATA5

2.03e-03131542DOID:6419 (is_implicated_in)
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GABRB2 ASH1L GRIN2A

2.15e-03491543DOID:0060037 (implicated_via_orthology)
Diseaseventricular septal defect (is_implicated_in)

GATA4 GATA5

2.36e-03141542DOID:1657 (is_implicated_in)
DiseaseIntellectual Disability

GABRB2 IQSEC3 DOCK8 ASH1L SCN1A SCN3A SCN8A CACNA1G

2.49e-034471548C3714756
DiseaseMMR-related febrile seizures

SCN1A SCN2A

2.72e-03151542EFO_0006519
DiseaseSinus Node Dysfunction (disorder)

CACNA1D SCN10A

2.72e-03151542C0428908
DiseaseNeuralgia, Supraorbital

SCN9A SCN10A

3.10e-03161542C0038870
DiseaseNeuralgia

SCN9A SCN10A

3.10e-03161542C0027796
DiseaseTetralogy of Fallot

GATA4 GATA5

3.10e-03161542C0039685
DiseaseNeuralgia, Atypical

SCN9A SCN10A

3.10e-03161542C0234247
DiseaseNeuralgia, Stump

SCN9A SCN10A

3.10e-03161542C0234249
DiseaseNeuralgia, Iliohypogastric Nerve

SCN9A SCN10A

3.10e-03161542C0423712
DiseaseNeuralgia, Perineal

SCN9A SCN10A

3.10e-03161542C0423711
DiseaseParoxysmal Nerve Pain

SCN9A SCN10A

3.10e-03161542C0751373
DiseaseNerve Pain

SCN9A SCN10A

3.10e-03161542C0751372
DiseaseNeuralgia, Ilioinguinal

SCN9A SCN10A

3.10e-03161542C0751371
DiseaseNeuralgia, Vidian

SCN9A SCN10A

3.10e-03161542C0042656
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

3.10e-03161542C0393706
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

GABRB2 CACNA1D GAPVD1 NOL6 GPR135 GRIN2A DDB2 ZNF518A PHF20L1 SCN2A PDE11A

3.31e-0380115411EFO_0003888, EFO_0007052, MONDO_0002491
DiseaseBenign neoplasm of stomach

ATR ATM

3.50e-03171542C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

ATR ATM

3.50e-03171542C0496905
DiseaseCarcinoma in situ of stomach

ATR ATM

3.50e-03171542C0154060
DiseaseColorectal Carcinoma

DPYSL2 GATA4 PSMC5 GATA5 GRIN2A ERI2 KCNB2 TIAM1 SH3TC1 DHFR

3.91e-0370215410C0009402
DiseaseSquamous cell carcinoma

DOCK8 DDB2 TIAM1 ATM

4.12e-031241544C0007137
DiseaseBrugada syndrome

GATA4 SCN10A

4.37e-03191542MONDO_0015263
Diseasehepatitis B virus infection

GRIN2A AFG1L

4.37e-03191542EFO_0004197
DiseaseSystemic Scleroderma

HDAC5 S1PR5

4.37e-03191542C0036421
Diseaseleukemia (implicated_via_orthology)

ASH1L ATM

4.37e-03191542DOID:1240 (implicated_via_orthology)
Diseaseoral squamous cell carcinoma (is_marker_for)

PTGIS ATM DOCK6

4.40e-03631543DOID:0050866 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
LDSALLRPGRIDRKI

PSMC5

301

P62195
RIDLLAQPRRTRLGS

CEP170

1146

Q5SW79
LARQLGLIRRKSIAP

ERI2

6

A8K979
LLVTTRGRNRLPKDV

ABLIM3

626

O94929
RGRNRLPKDVDRTRL

ABLIM3

631

O94929
LLKRLSRNGAPLLRR

BRD1

481

O95696
SGRKLRRRTLFIPEN

ASH1L

2951

Q9NR48
EDPGKLTGLRRRRRT

GRAMD1C

501

Q8IYS0
GVKRRVRQLRGLPLL

ARVCF

391

O00192
GPRRSRLNREQLLPK

BARD1

656

Q99728
RLRSLRKLLAQPREG

B4GALNT3

471

Q6L9W6
QPLPTKRRRALLRAS

CSRNP2

176

Q9H175
RPRKRLTELLLRTAT

FDXR

271

P22570
LTRPRILKVQGRELR

AFG1L

321

Q8WV93
KRSLGLEDPSRLRSR

DCAF6

16

Q58WW2
FSKRLQGRLPGLRVR

DIPK1B

16

Q5VUD6
SLLRLRLRKVALAPG

DENND1C

311

Q8IV53
RLRSKAESSLLRRGP

C1orf115

6

Q9H7X2
LLWLLERRLKRPRTQ

DCLRE1B

336

Q9H816
VLVRLRKRLSPGRGQ

CCDC157

726

Q569K6
ALLPSGARRRIDLRL

C7orf33

26

Q8WU49
RPPTRLQDRLLRKLG

ARRB2

96

P32121
RGLLSGLRRRKRPLS

GRAMD1A

546

Q96CP6
SLRLGLSRLARVKPL

RAD51AP1

331

Q96B01
PRLLGRLARLIKEAV

RASIP1

596

Q5U651
RNRRKILIRGLPGDV

RAVER1

56

Q8IY67
RTRVGRPAALRLLLL

RAMP2

16

O60895
RQKFPLLTTRRLGTR

RFX6

171

Q8HWS3
TTRKNHGPRLRLLLR

RFNG

66

Q9Y644
PLIRKKSLRRTLSER

PGA5

21

P0DJD9
SPRLRLQALGTRRLL

OBSL1

1671

O75147
PRLSRSAELIRKLDG

RSPH10B

361

P0C881
PRLSRSAELIRKLDG

RSPH10B2

361

B2RC85
LRVLRPLRAINRAKG

CACNA1F

971

O60840
AALLKSLRSRLRDGP

MAPK7

481

Q13164
QLILSRRPRRRLGSL

NOL9

26

Q5SY16
RQLRRLSRQPRGALS

ESPNL

821

Q6ZVH7
RGRRLSAIFLRLPSR

PBRM1

676

Q86U86
RRGLLARPLNSKARG

H1-8

106

Q8IZA3
ISRGKLLPRERIDNL

MCCC2

76

Q9HCC0
SLGENLKTLRLRLRR

IL10

111

P22301
AGATLNRLREPLLRR

MALT1

26

Q9UDY8
RIKARSRLAELRGVP

DPYSL2

481

Q16555
LKESDNPRRLLRRGT

GAPVD1

161

Q14C86
GRVRSLLPLALRRGK

JPH4

341

Q96JJ6
ALLLSIQRRLPRERK

MFSD6L

536

Q8IWD5
EKRRRLLESLRGPAL

MOAP1

201

Q96BY2
DLGLSVRELPTRKLR

PCDHGB1

51

Q9Y5G3
QEPLSSVRRRALLRK

PDE11A

146

Q9HCR9
SVRRRALLRKASSLP

PDE11A

151

Q9HCR9
GRKNSRTMLLPLLRR

PGS1

171

Q32NB8
KGARRLKLSPLRSLR

FAM214B

311

Q7L5A3
SLLLRPRGKDERLVT

NOL6

236

Q9H6R4
LPALLLRRLRRGSLS

DUSP9

46

Q99956
VLRRPQKGRLAALRD

PPFIA1

551

Q13136
LPRLRVLRLRGNQLK

LINGO3

101

P0C6S8
RLRRRASQLKITIPD

GABRB2

466

P47870
LKRRLSRKLSLRPTV

PHACTR2

551

O75167
GLRTLLPVFLRARKL

NLRX1

741

Q86UT6
PDAQLLARRFLLRRK

PTGS1

171

P23219
VLRPRNKRSRSPLEL

DDB2

16

Q92466
EKIRNSLLESRLPRR

IQSEC3

336

Q9UPP2
SLLESRLPRRISLRK

IQSEC3

341

Q9UPP2
LPGQRLDRLGSRKRR

MED26

136

O95402
PLIRKKSLRRTLSER

PGA3

21

P0DJD8
LPAVLRALKGRAARR

SBF1

586

O95248
RRLSLGSRLELPKAS

PRR35

336

P0CG20
NRPLIKPQRRLSASR

GATA4

251

P43694
KPQRRLSASRRVGLS

GATA4

256

P43694
LVRPQKRLSSSRRAG

GATA5

226

Q9BWX5
LPLTRLEGLKDLRRQ

ATM

1606

Q13315
LALRRALLSLNKRPD

ATR

1901

Q13535
PPREKIGRRRALQLL

GPR135

216

Q8IZ08
RTLDRLPRTRLGKLR

KCNB2

51

Q92953
RVLRPLRAINRAKGL

CACNA1C

1021

Q13936
LLLGQRLDTPRKLRF

DOCK6

946

Q96HP0
SLQRRVKSIPGLLRL

DOCK8

496

Q8NF50
LIFRRRPRQKEAGLS

C2CD2L

646

O14523
LRPLRVISRAQGLKL

CACNA1G

1386

O43497
RPLKGRINLVLSREL

DHFR

66

P00374
GLLAPGRRKQRLRLS

CENPT

146

Q96BT3
IPGREELRSLARQRK

DLGAP3

616

O95886
QLGLSLRRSGRQPKR

DIDO1

56

Q9BTC0
LRRLRKGNLPIRSII

DUSP7

101

Q16829
LLRRRGLQKELSLPR

MAST3

6

O60307
RIKNLLRSPSIKLRR

MAPKBP1

11

O60336
RLRLAPPKTRRGSSL

FAM47A

361

Q5JRC9
RRSSPLLRRKDGTVI

HDAC5

276

Q9UQL6
VLRKGSLRLRQLLSP

FAM83H

961

Q6ZRV2
SLRLRQLLSPKGERR

FAM83H

966

Q6ZRV2
LAGARKLLASQPLRR

CERCAM

481

Q5T4B2
DSKELQRRRRSLALP

GRK7

26

Q8WTQ7
RGLLERRRAKLGLSP

PPP1R18

41

Q6NYC8
RRKPRSLALLRTLSV

S1PR5

241

Q9H228
RRAGRLLLTLPLLRQ

ESRRA

376

P11474
SPRKARRARLNPLVL

PPP1R13L

616

Q8WUF5
LRVLRPLRAINRAKG

CACNA1D

986

Q01668
VPSLRRLDLGELKRL

LRRC4B

181

Q9NT99
PRNKVDATLRRLLER

PIDD1

636

Q9HB75
PLIRKKSLRRTLSER

PGA4

21

P0DJD7
DSNRLRPLERPALRK

PHF20L1

61

A8MW92
FRLALPRIRKGSRLQ

GRIN3B

856

O60391
SGLRPEERLIRLSRN

RNF139

341

Q8WU17
LSRRTLPKPDRLDRL

TRIM46

91

Q7Z4K8
LLRRLKASRPRRGGI

TRIM47

571

Q96LD4
RSLKRAALQRPGIRR

TRMT5

111

Q32P41
LLPRKRSRSRSPLAI

SRRM2

2036

Q9UQ35
ELGPIKSLRTLRALR

SCN4A

1121

P35499
KSLRTLRALRPLRAL

SCN4A

1126

P35499
KQGFRRVLLRPSRRV

SSTR3

321

P32745
SLLLRPQLGTRKVAR

SERTAD4-AS1

36

Q5TG53
LRRRKTISGIPRRVQ

NHS

396

Q6T4R5
TFRQLDRLLPKLARG

PTGIS

206

Q16647
QPQKRRLLRRLLDGV

IQCA1L

66

A6NCM1
LRKFLQRRPTLQSLR

ARHGAP27

671

Q6ZUM4
FPRQLRKSGRRELLI

SLC6A12

411

P48065
ITLLKTRGPFRKRLR

SLC6A12

556

P48065
ILVASPLRALRARGK

SEMA4A

701

Q9H3S1
IKSLRTLRALRPLRA

SCN9A

1286

Q15858
ENRRPLLRKGRLLRG

SMCR5

116

Q8TEV8
LQLLAVRRKSRLRDP

SH3TC1

86

Q8TE82
LGPALKIRAQVARRL

SAMD11

591

Q96NU1
QLLAKGRRHRPSRSR

SAMD14

36

Q8IZD0
RTLRVLLDSPVKRRL

WHRN

76

Q9P202
KSLRTLRALRPLRAL

SCN3A

1301

Q9NY46
VLDVLGQRRPSLAKR

RNF217

146

Q8TC41
LIRRRRSILFPNGVK

IMPG2

76

Q9BZV3
LDRQKPRQGRRVLLL

ITGA2B

541

P08514
LRRSSRPLLENGAKV

NUAK2

336

Q9H093
LLRRNPERRLGASEK

PKN2

891

Q16513
NPRARKNRSRIPLLR

SPDYE2B

296

A6NHP3
NPRARKNRSRIPLLR

SPDYE2B

321

A6NHP3
AIKSLRTLRALRPLR

SCN1A

1311

P35498
RLRLAGLTVSSPLKR

SSH1

961

Q8WYL5
LKRQSRNGVPLLRRL

BRPF1

546

P55201
QRRPSRLRGKRSLAL

CSNK1G2-AS1

96

Q8NCQ2
KQLSLGRPRRLRRQS

C15orf62

16

A8K5M9
TRLALPGRQGRRALK

C11orf42

61

Q8N5U0
TLRLPRTGRLLRAKR

ATG4D

451

Q86TL0
KRRRLLESLRGPALS

PNMA5

196

Q96PV4
RESLDILAPGRRRKN

PLEKHG5

191

O94827
SPQLEKSRIRLRRTL

TLX1NB

96

P0CAT3
KSRIRLRRTLRNLGG

TLX1NB

101

P0CAT3
LRRRQALRGKSSPVL

ZC3H3

476

Q8IXZ2
RRLLRRLSPSRGVAQ

ZSWIM9

411

Q86XI8
KRGLRQLRRPLLSRQ

UNC80

3061

Q8N2C7
VSAPSKSLGRRRRRL

TIAM1

1436

Q13009
PRLVRAGSRILDKLQ

SPEG

391

Q15772
RRERNKALVGSRRPL

PRR19

26

A6NJB7
RILRSRRSPLLKSGP

KIF20A

871

O95235
IKALRTLRALRPLRA

SCN10A

1246

Q9Y5Y9
LQSLPLESRRKGRNR

SEMA3B

716

Q13214
NPRARKNRSRIPLLR

SPDYE21

296

A0A494C086
NPRARKNRSRIPLLR

SPDYE2

296

Q495Y8
NPRARKNRSRIPLLR

SPDYE2

321

Q495Y8
NPRARKNRSRIPLLR

SPDYE5

321

A6NIY4
NPRARKNRSRIPLLR

SPDYE6

296

P0CI01
NPRARKNRSRIPLLR

SPDYE6

321

P0CI01
ATPGARRLLRITKRT

ZC3H11A

501

O75152
DLKRALRELGSVPLR

MTHFSD

321

Q2M296
AIKSLRTLRALRPLR

SCN2A

1301

Q99250
AIKSLRTLRALRPLR

SCN8A

1291

Q9UQD0
RPRLSKDSIRTLRLF

ZNF518A

1316

Q6AHZ1
PLRERARKLSQGILI

YJU2B

31

P13994
RLSEGKLVSRPRALL

UBAP1L

161

F5GYI3
QRRLSEALKRLRSGP

TNK1

56

Q13470
EIRKRLRSDRLLPSA

STMND1

186

H3BQB6
LLPGADRKRSRLSRT

TCF23

26

Q7RTU1
ARLARKTLPRLTEQG

TOGARAM1

571

Q9Y4F4
VERKRPGRLLRTDRQ

USP40

1026

Q9NVE5
RLLRSRAGSRKRPLT

ZFPL1

246

O95159
RAGSRKRPLTLLQRA

ZFPL1

251

O95159
LLKQEPRGRRLSSLT

nan

356

Q8N7P7
PRAGRAALQLKLRRR

TNFRSF6B

246

O95407
RRLRKELRAQQGLAP

N4BP3

331

O15049
RPSRSISLKDRERLL

GRIN2A

1306

Q12879