Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	4.62e-05	4	56	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	4.62e-05	4	56	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	4.62e-05	4	56	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	4.62e-05	4	56	2	GO:0106309
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	1.15e-04	6	56	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	1.15e-04	6	56	2	GO:0062186
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1E	2.75e-04	9	56	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1E	2.75e-04	9	56	2	GO:0099626
GeneOntologyMolecularFunction	3'-5' exonuclease activity	POLE ANGEL2 POLRMT	6.70e-04	61	56	3	GO:0008408
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1E	6.88e-04	14	56	2	GO:0008331
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	EIF4E3 EIF4E2	6.88e-04	14	56	2	GO:0000340
GeneOntologyMolecularFunction	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	POLE ANGEL2 POLRMT	7.03e-04	62	56	3	GO:0016796
GeneOntologyMolecularFunction	RNA cap binding	EIF4E3 EIF4E2	1.57e-03	21	56	2	GO:0000339
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	TARS3 PUS3 ERCC6 POLE ANGEL2 POLRMT DDX20	2.09e-03	645	56	7	GO:0140640
GeneOntologyMolecularFunction	exonuclease activity	POLE ANGEL2 POLRMT	2.20e-03	92	56	3	GO:0004527
GeneOntologyMolecularFunction	metalloaminopeptidase activity	MMP15 LAP3	2.40e-03	26	56	2	GO:0070006
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2D7 CYP2D6	2.59e-03	27	56	2	GO:0008391
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2D7 CYP2D6	4.09e-03	34	56	2	GO:0008395
GeneOntologyMolecularFunction	monooxygenase activity	CYP2D7 CYP2D6 MIOX	4.13e-03	115	56	3	GO:0004497
GeneOntologyMolecularFunction	aromatase activity	CYP2D7 CYP2D6	4.33e-03	35	56	2	GO:0070330
GeneOntologyBiologicalProcess	serotonin biosynthetic process from tryptophan	CYP2D7 CYP2D6	2.09e-05	3	55	2	GO:0006587
MousePheno	decreased circulating adrenocorticotropin level	POMC DDX20 PTGER3	5.40e-06	11	46	3	MP:0002664
MousePheno	decreased adrenocorticotropin level	POMC DDX20 PTGER3	2.63e-05	18	46	3	MP:0005128
Domain	IF4E	EIF4E3 EIF4E2	5.09e-05	4	55	2	PS00813
Domain	IF4E	EIF4E3 EIF4E2	5.09e-05	4	55	2	PF01652
Domain	GLYCOSYL_HYDROL_F31_2	SI MYORG	8.47e-05	5	55	2	PS00707
Domain	DDE_Tnp_1_7	ERCC6 PGBD1	8.47e-05	5	55	2	PF13843
Domain	PGBD	ERCC6 PGBD1	8.47e-05	5	55	2	IPR029526
Domain	-	EIF4E3 EIF4E2	8.47e-05	5	55	2	3.30.760.10
Domain	TIF_eIF_4E	EIF4E3 EIF4E2	8.47e-05	5	55	2	IPR001040
Domain	TIF_eIF4e-like	EIF4E3 EIF4E2	8.47e-05	5	55	2	IPR023398
Domain	DUF3398	DOCK9 DOCK6	1.27e-04	6	55	2	PF11878
Domain	DOCK_C/D_N	DOCK9 DOCK6	1.27e-04	6	55	2	IPR021816
Domain	VDCC_a1su_IQ	CACNA1A CACNA1E	1.77e-04	7	55	2	IPR014873
Domain	Glyco_hydro_31	SI MYORG	1.77e-04	7	55	2	IPR000322
Domain	GPHH	CACNA1A CACNA1E	1.77e-04	7	55	2	PF16905
Domain	Glyco_hydro_31	SI MYORG	1.77e-04	7	55	2	PF01055
Domain	GPHH_dom	CACNA1A CACNA1E	1.77e-04	7	55	2	IPR031649
Domain	Ca_chan_IQ	CACNA1A CACNA1E	1.77e-04	7	55	2	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1E	1.77e-04	7	55	2	PF08763
Domain	GLYCOSYL_HYDROL_F31_1	SI MYORG	1.77e-04	7	55	2	PS00129
Domain	VDCCAlpha1	CACNA1A CACNA1E	3.77e-04	10	55	2	IPR002077
Domain	DOCK_C	DOCK9 DOCK6	4.60e-04	11	55	2	IPR010703
Domain	DHR-1_domain	DOCK9 DOCK6	4.60e-04	11	55	2	IPR027007
Domain	DHR_2	DOCK9 DOCK6	4.60e-04	11	55	2	PS51651
Domain	DHR_1	DOCK9 DOCK6	4.60e-04	11	55	2	PS51650
Domain	DOCK-C2	DOCK9 DOCK6	4.60e-04	11	55	2	PF14429
Domain	DHR-2	DOCK9 DOCK6	4.60e-04	11	55	2	IPR027357
Domain	DHR-2	DOCK9 DOCK6	4.60e-04	11	55	2	PF06920
Domain	DOCK	DOCK9 DOCK6	4.60e-04	11	55	2	IPR026791
Domain	SRCR	PGBD1 LOXL4	2.85e-03	27	55	2	IPR001190
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TYK2 SETD1A CLCN7 POLE DOCK9 SORBS3 POLRMT DYSF DOCK6 DYNC1H1 MYORG MVB12B	1.53e-07	1105	56	12	35748872
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	YEATS2 CLCN7 FAM120C DOCK9 DOCK6	1.83e-06	125	56	5	29467281
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	2.55e-06	2	56	2	11032406
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	2.55e-06	2	56	2	16381801
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	2.55e-06	2	56	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	2.55e-06	2	56	2	11207030
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	2.55e-06	2	56	2	3123997
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	2.55e-06	2	56	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	2.55e-06	2	56	2	26297049
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	2.55e-06	2	56	2	15051713
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	7.63e-06	3	56	2	2574001
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1E	7.63e-06	3	56	2	38996073
Pubmed	Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?	EIF4E3 EIF4E2	7.63e-06	3	56	2	28942592
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1E	7.63e-06	3	56	2	24523520
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	7.63e-06	3	56	2	1978251
Pubmed	Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules.	EIF4E3 EIF4E2	7.63e-06	3	56	2	27578149
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1E	1.52e-05	4	56	2	32616470
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1E	1.52e-05	4	56	2	37141091
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1E	2.54e-05	5	56	2	8825650
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1E	2.54e-05	5	56	2	15451373
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1E	2.54e-05	5	56	2	11296258
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1A CACNA1E	3.80e-05	6	56	2	35324301
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1A CACNA1E	3.80e-05	6	56	2	12827191
Pubmed	Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.	CYP2D7 CYP2D6	3.80e-05	6	56	2	12171760
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1A CACNA1E	3.80e-05	6	56	2	9238069
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1A CACNA1E	5.32e-05	7	56	2	35176221
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP2D7 CYP2D6	5.32e-05	7	56	2	30944282
Pubmed	Characterization of mammalian eIF4E-family members.	EIF4E3 EIF4E2	5.32e-05	7	56	2	15153109
Pubmed	Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.	ERCC6 POLE	5.32e-05	7	56	2	17855454
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1E	9.10e-05	9	56	2	16382099
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK9 DOCK6	2.29e-04	14	56	2	12432077
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1A CACNA1E	2.64e-04	15	56	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1A CACNA1E	2.64e-04	15	56	2	24453333
Pubmed	KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR).	SETD1A ERCC6	3.41e-04	17	56	2	22902626
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	ERCC6 POLE POLRMT	3.43e-04	84	56	3	19237606
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	POLE FBXW5 DYNC1H1 EIF4E2	5.40e-04	232	56	4	25515538
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	POLE DDX20 WDR25 MTX1 MVB12B	5.71e-04	419	56	5	28700943
Pubmed	The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.	GPR50 POMC	6.30e-04	23	56	2	25505333
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	YEATS2 ATP6AP1 CLCN7 POLRMT MTX1	8.44e-04	457	56	5	32344865
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	TARS3 FAM120C FIBP DDX20 EIF4E2	8.86e-04	462	56	5	31138677
Pubmed	Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer.	SORBS3 WDR25	9.37e-04	28	56	2	25356737
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	YEATS2 SETD1A POLRMT	9.49e-04	119	56	3	23508102
Pubmed	Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.	CYP2D6 POMC PTGER3	1.09e-03	125	56	3	19019335
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	ERCC6 ANGEL2 POLRMT DYSF	1.10e-03	281	56	4	24163370
Pubmed	The DNA sequence and biology of human chromosome 19.	CACNA1A SHC2 EBI3 POLRMT	1.15e-03	284	56	4	15057824
Pubmed	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	CYP2D6 POMC PTGER3	1.17e-03	128	56	3	18818748
Pubmed	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	CYP2D6 POMC PTGER3	1.17e-03	128	56	3	19527514
Pubmed	Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.	CYP2D6 GATM	1.30e-03	33	56	2	16618389
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MYO3A DYNC1H1	1.38e-03	34	56	2	25925205
Pubmed	Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.	SHC2 EBI3	1.46e-03	35	56	2	10984455
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1A CACNA1E CLCN7	1.48e-03	139	56	3	16985003
Pubmed	Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies.	CLCN7 EIF4E2	1.55e-03	36	56	2	33263384
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	CACNA1E GPR50 POMC	1.61e-03	143	56	3	20424473
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	TYK2 CACNA1A SHC2 EBI3 POLRMT DOCK6	4.17e-04	797	56	6	chr19p13
Cytoband	1p34.1	TMEM53 ZSWIM5	2.23e-03	57	56	2	1p34.1
Cytoband	19p13.3	SHC2 EBI3 POLRMT	3.08e-03	237	56	3	19p13.3
Cytoband	2p23.3	MPV17 POMC	3.16e-03	68	56	2	2p23.3
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1E	1.02e-03	26	33	2	253
GeneFamily	Cytochrome P450 family 2	CYP2D7 CYP2D6	1.85e-03	35	33	2	1001
CoexpressionAtlas	ratio_induced-Mesoderm_vs_StemCell_top-relative-expression-ranked_1000_k-means-cluster#5	MYO3A CYP2D7 CYP2D6 SHC2 POMC GATM MMP15 MYORG	2.69e-05	480	54	8	ratio_MESO_vs_SC_1000_K5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A CACNA1E GATM SVOP	5.79e-05	167	56	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	Control-CD4+_T_activated\|World / Disease group and Cell class	SETD1A CFAP54 EBI3 EIF4E3	6.63e-05	173	56	4	12f8e4276b290bb388a56de4c8d8dd60415b2f63
ToppCell	IIH-CD8-naive_CD4\|IIH / Condition, Cell_class and T cell subcluster	SETD1A ERCC6 CLCN7 POLE	6.63e-05	173	56	4	4f2843371d18af766c1892529ce286f56c956fde
ToppCell	Control-CD4+_T_activated\|Control / Disease group and Cell class	SETD1A CFAP54 EBI3 EIF4E3	6.78e-05	174	56	4	2b683e81b315ad22555314433aed5681feb48da8
ToppCell	NS-critical-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TMEM53 WDR25 PTGER3 MYORG	7.90e-05	181	56	4	cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ZNF280A DOCK9 MMP15 DOCK6	8.07e-05	182	56	4	997d37ca2af661c92a56add888762724dfccc890
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHC2 DOCK9 DYSF DOCK6	8.25e-05	183	56	4	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHC2 DOCK9 ITGA10 DOCK6	9.53e-05	190	56	4	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-tip_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	9.73e-05	191	56	4	cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK9 ITGA10 DYSF DOCK6	1.01e-04	193	56	4	f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK9 ITGA10 DYSF DOCK6	1.03e-04	194	56	4	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	SHC2 DOCK9 DYSF DOCK6	1.05e-04	195	56	4	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	Children_(3_yrs)-Endothelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHC2 DOCK9 DYSF DOCK6	1.05e-04	195	56	4	094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCell	Fetal_29-31_weeks-Endothelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHC2 DOCK9 DYSF DOCK6	1.07e-04	196	56	4	3981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	SHC2 DOCK9 DYSF DOCK6	1.07e-04	196	56	4	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	Endothelial\|World / Lineage, Cell type, age group and donor	SHC2 DOCK9 DYSF DOCK6	1.07e-04	196	56	4	96c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 ITGA10 DYSF DOCK6	1.10e-04	197	56	4	15d1e0dffee8f5ba8cee37adfbfa0551a0cd5e15
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 ITGA10 DYSF DOCK6	1.10e-04	197	56	4	ca6bce1a92c6326f41a6300c31da02386bafa152
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-tip_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	1.10e-04	197	56	4	b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCell	10x5'v1-week_12-13-Endothelial\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	1.12e-04	198	56	4	307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	1.12e-04	198	56	4	1e83bec16dcd60460422625f89952ff506d6be51
ToppCell	10x3'2.3-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	1.12e-04	198	56	4	2630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 ITGA10 DYSF LAP3	1.12e-04	198	56	4	0c8ec287500c58938ecc0dbbbc5f6c7a48733fc6
ToppCell	10x5'v1-week_12-13-Endothelial-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	1.12e-04	198	56	4	122215d9288533ad03562cf777e846504863df9a
ToppCell	(6)_Endothelial-E\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	DOCK9 ITGA10 DYSF DOCK6	1.12e-04	198	56	4	a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCell	10x3'2.3-week_14-16-Endothelial\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	1.14e-04	199	56	4	41f046646fff65b7e51b63d3204f76ef32054781
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	EBI3 GATM LILRA5 LAP3	1.14e-04	199	56	4	c051cc3e42cfa2ec09fd8dae1172af350bb2dfcb
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-4\|TCGA-Skin / Sample_Type by Project: Shred V9	MPV17 ATP6AP1 FBXW5 MTX1	1.14e-04	199	56	4	bbda9060918797303984ca2b64e9bb73fdacd0c4
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Erythrophagocytic_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	EBI3 GATM LILRA5 LAP3	1.14e-04	199	56	4	78db2e3b85356ed2f08794e5a97c16a220f8a076
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SHC2 DOCK9 MMP15 DOCK6	1.14e-04	199	56	4	ef7f7f7c861827574b120f48cf4052c563929081
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	DOCK9 SORBS3 DYSF LAP3	1.16e-04	200	56	4	432384faeade8e609154fab3d96c955a8ec868dd
Drug	cupreidine	CYP2D7 CYP2D6	5.94e-06	2	56	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	5.94e-06	2	56	2	CID000074866
Drug	Convolamine hydrochloride [500-56-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SETD1A CLCN7 ANGEL2 SORBS3 MMP15 DOCK6	9.07e-06	198	56	6	2771_DN
Drug	N-desisopropylpropranolol	CYP2D7 CYP2D6 LOXL4	9.35e-06	17	56	3	CID000159899
Drug	mirtazapine	CYP2D7 CYP2D6 POMC LOXL4	9.47e-06	54	56	4	CID000004205
Drug	Dicloxacillin sodium salt [13412-64-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A	CLCN7 FAM120C ITGA10 WDR25 MMP15 DOCK6	9.60e-06	200	56	6	5012_DN
Drug	m-tyramine	CYP2D7 CYP2D6 LOXL4	1.33e-05	19	56	3	CID000011492
Drug	moclobemide	CYP2D7 CYP2D6 POMC LOXL4	1.65e-05	62	56	4	CID000004235
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	1.78e-05	3	56	2	CID000443037
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	1.78e-05	3	56	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	1.78e-05	3	56	2	CID000054736
Drug	AC1NUT2K	CACNA1A LAP3	1.78e-05	3	56	2	CID005492318
Drug	hydroxyamphetamine	CYP2D7 CYP2D6 LOXL4	1.82e-05	21	56	3	CID000003651
Drug	AC1L1TJF	CACNA1A CACNA1E CYP2D7 CYP2D6	2.11e-05	66	56	4	CID000003377
Drug	CAS 298-57-7	CACNA1A CACNA1E CYP2D7 CYP2D6	3.15e-05	73	56	4	CID000002761
Drug	H3-32	CYP2D7 CYP2D6 LOXL4	3.52e-05	26	56	3	CID000082553
Drug	AC 110	CACNA1A CACNA1E	3.55e-05	4	56	2	CID000022860
Drug	4,4'-difluorobenzophenone	CYP2D7 CYP2D6	3.55e-05	4	56	2	CID000009582
Drug	Z-10	CYP2D7 CYP2D6	3.55e-05	4	56	2	CID000477529
Drug	1-(1-phenylcyclohexyl)-4-piperidinol	CYP2D7 CYP2D6	3.55e-05	4	56	2	CID000098840
Drug	desethylaprindine	CYP2D7 CYP2D6	3.55e-05	4	56	2	CID000162697
Drug	Q740	CYP2D7 CYP2D6 POMC LOXL4	5.22e-05	83	56	4	CID000005203
Drug	milnacipran	CYP2D7 CYP2D6 LOXL4	5.46e-05	30	56	3	CID000055480
Drug	eptapirone	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID000208928
Drug	Koe 1801	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID000129632
Drug	2Cmp	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID000023392
Drug	L-754,394	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID005481990
Drug	oxosparteine	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID000097492
Drug	threohydrobupropion	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID000000445
Drug	4-hydroxyochratoxin A	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID000114713
Drug	fenproporex	CYP2D7 CYP2D6	5.91e-05	5	56	2	CID000061810
Drug	AC-680	CYP2D7 CYP2D6 POMC LOXL4	8.14e-05	93	56	4	CID000004691
Drug	amsonine	CACNA1A CACNA1E POMC LOXL4 PTGER3	8.26e-05	181	56	5	CID000002866
Drug	8-Methylxanthine	CYP2D7 CYP2D6	8.86e-05	6	56	2	CID000087061
Drug	AC1L45F6	CYP2D7 CYP2D6	8.86e-05	6	56	2	CID000150982
Drug	KRM1674	CYP2D7 CYP2D6	8.86e-05	6	56	2	CID000126235
Drug	5-dehydrosparteine	CYP2D7 CYP2D6	8.86e-05	6	56	2	CID000160614
Drug	nitroguanidine	CYP2D7 CYP2D6	8.86e-05	6	56	2	CID000011174
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1E	8.86e-05	6	56	2	CID000583065
Drug	10-hydroxyochratoxin A	CYP2D7 CYP2D6	8.86e-05	6	56	2	CID000135115
Drug	Loperamide	CACNA1A POMC	8.86e-05	6	56	2	DB00836
Drug	alpha-sialylcholesterol	CACNA1A CACNA1E	8.86e-05	6	56	2	CID000133976
Drug	DMNM	CACNA1A POMC	8.86e-05	6	56	2	CID000015081
Drug	7-hydroxychlorpromazine	CYP2D7 CYP2D6	8.86e-05	6	56	2	CID000016414
Drug	AC1L3NGJ	CYP2D7 CYP2D6 POMC	9.50e-05	36	56	3	CID000092121
Drug	isradipine	CACNA1A CACNA1E CYP2D7 CYP2D6	1.08e-04	100	56	4	CID000003784
Drug	almotriptan	CYP2D7 CYP2D6 LOXL4	1.12e-04	38	56	3	CID000123606
Drug	Estradiol-17 beta [50-28-2]; Up 200; 14.6uM; PC3; HT_HG-U133A	ZNF280A SETD1A DOCK6 LILRA5 MVB12B	1.17e-04	195	56	5	6718_UP
Drug	Hydrocortisone base [50-23-7]; Down 200; 11uM; MCF7; HT_HG-U133A	TMEM53 ERCC6 CLCN7 SORBS3 DOCK6	1.20e-04	196	56	5	3284_DN
Drug	Torsemide [56211-40-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A	SETD1A SHC2 GATM WDR25 PTGER3	1.20e-04	196	56	5	3517_UP
Drug	Equilin [474-86-2]; Down 200; 15uM; HL60; HT_HG-U133A	TMEM53 SORBS3 ITGA10 DYSF DOCK6	1.23e-04	197	56	5	3039_DN
Drug	Ben 101	CYP2D7 CYP2D6	1.24e-04	7	56	2	CID000090766
Drug	azoprocarbazine	CYP2D7 CYP2D6	1.24e-04	7	56	2	CID000075230
Drug	APMPA	CACNA1A CACNA1E	1.24e-04	7	56	2	CID000512300
Drug	quinidine-N-oxide	CYP2D7 CYP2D6	1.24e-04	7	56	2	CID000050979
Drug	2-sulfamoylacetylphenol	CYP2D7 CYP2D6	1.24e-04	7	56	2	CID000194588
Drug	phenyl isocyanide	CYP2D7 CYP2D6	1.24e-04	7	56	2	CID000013606
Drug	ICI-199,441	CYP2D7 CYP2D6	1.24e-04	7	56	2	CID003082717
Drug	5,6-Dehydro-sparteine	CYP2D7 CYP2D6	1.24e-04	7	56	2	CID000523578
Drug	Sulfapyridine [144-83-2]; Up 200; 16uM; MCF7; HT_HG-U133A	ZNF280A CACNA1A CLCN7 ANGEL2 MMP15	1.26e-04	198	56	5	6799_UP
Drug	Tolazoline hydrochloride [59-97-2]; Up 200; 20.4uM; MCF7; HT_HG-U133A	ZNF280A FAM120C DOCK9 DOCK6 PTGER3	1.26e-04	198	56	5	4844_UP
Drug	Amiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; MCF7; HT_HG-U133A	CLCN7 ANGEL2 ITGA10 WDR25 DOCK6	1.26e-04	198	56	5	5253_DN
Drug	Gibberellic acid [77-06-5]; Up 200; 11.6uM; HL60; HT_HG-U133A	SETD1A CLCN7 EBI3 ANGEL2 DOCK6	1.26e-04	198	56	5	2910_UP
Drug	Carbetapentane citrate [23142-01-0]; Up 200; 7.6uM; PC3; HT_HG-U133A	ZNF280A CACNA1A WDR25 MMP15 PTGER3	1.29e-04	199	56	5	4649_UP
Drug	Dioxybenzone [131-53-3]; Up 200; 16.4uM; HL60; HT_HG-U133A	FAM120C DOCK9 SORBS3 DOCK6 PTGER3	1.29e-04	199	56	5	3101_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	CACNA1A SETD1A TMEM53 CLCN7 PTGER3	1.29e-04	199	56	5	3058_DN
Drug	doxepin	CYP2D7 CYP2D6 LOXL4	1.31e-04	40	56	3	CID000003158
Drug	tamoxifen citrate; Up 200; 1uM; ssMCF7; HG-U133A	CACNA1A TMEM53 PUS3 SORBS3 DYSF	1.32e-04	200	56	5	375_UP
Drug	Butacaine [149-16-6]; Up 200; 13uM; MCF7; HT_HG-U133A	FAM120C SORBS3 DYSF MMP15 PTGER3	1.32e-04	200	56	5	6225_UP
Drug	nefazodone	CYP2D7 CYP2D6 LOXL4	1.62e-04	43	56	3	CID000004449
Drug	MPBP	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000129775
Drug	iodoquinol	SNRNP35 DYNC1H1	1.65e-04	8	56	2	CID000003728
Drug	pirprofen	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000035935
Drug	phenmetrazine	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000004762
Drug	AC1L9DBW	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000442742
Drug	HCBz	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000196604
Drug	beta-site	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000003914
Drug	hydroxynortriptyline	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID005352542
Drug	L-754394	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000153982
Drug	B.W.306U	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000000446
Drug	Z H-H	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000004657
Drug	3,4-dihydroxymethamphetamine	CYP2D7 CYP2D6	1.65e-04	8	56	2	CID000161126
Drug	maprotiline	CYP2D7 CYP2D6 LOXL4	1.74e-04	44	56	3	CID000004011
Drug	promethazine	CYP2D7 CYP2D6 POMC	1.98e-04	46	56	3	CID000004927
Drug	3-amino-2-butanone	CYP2D7 CYP2D6 MMP15	1.98e-04	46	56	3	CID004472117
Drug	hydroquinidine hydrochloride	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID000003649
Drug	p-hydroxymexiletine	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID000093286
Drug	norethylmorphine	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID005464196
Drug	O-demethylmetoprolol	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID000162181
Drug	guanoxan	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID000016564
Drug	1-chlorobutane	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID000008005
Drug	CP-101,606	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID000219101
Drug	AC1O3M98	CYP2D7 CYP2D6	2.12e-04	9	56	2	CID006332100
Drug	zinc methionine	SI LAP3	2.12e-04	9	56	2	CID000162430
Drug	AC1L1R04	CYP2D7 CYP2D6 DYNC1H1	2.12e-04	47	56	3	CID000008439
Drug	L024104	CACNA1E SI LAP3	2.25e-04	48	56	3	CID003025353
Drug	AC1LCF1O	CYP2D7 CYP2D6	2.64e-04	10	56	2	CID000627285
Drug	benzaldehyde oxime	CYP2D7 CYP2D6	2.64e-04	10	56	2	CID000012143
Drug	2-hydroxydesipramine	CYP2D7 CYP2D6	2.64e-04	10	56	2	CID000121249
Drug	norchlorpromazine	CYP2D7 CYP2D6	2.64e-04	10	56	2	CID000062875
Disease	Dystonia	CACNA1A MPV17 CACNA1E ERCC6 CYP2D6 MYORG	1.48e-08	86	56	6	C0013421
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1E	1.06e-05	3	56	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1E	2.12e-05	4	56	2	DOID:6364 (implicated_via_orthology)
Disease	solanidine measurement	CYP2D7 CYP2D6	2.12e-05	4	56	2	EFO_0800966
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1E	7.38e-05	7	56	2	DOID:0050951 (implicated_via_orthology)
Disease	Tonic-Clonic Epilepsy	CYP2D6 POMC	1.58e-04	10	56	2	C0014549
Disease	Cryptogenic Tonic-Clonic Epilepsy	CYP2D6 POMC	1.58e-04	10	56	2	C0751117
Disease	Epilepsy, Tonic-Clonic, Symptomatic	CYP2D6 POMC	1.58e-04	10	56	2	C0751119
Disease	Epilepsy, Tonic-Clonic, Familial	CYP2D6 POMC	1.58e-04	10	56	2	C0751118
Disease	Microcephaly	PUS3 ERCC6 DYNC1H1	2.85e-04	67	56	3	C0025958
Disease	serum homoarginine measurement	GATM WDR25	6.58e-04	20	56	2	EFO_0005421
Disease	Arthrogryposis	ERCC6 DYNC1H1	7.26e-04	21	56	2	C0003886
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	9.51e-04	24	56	2	EFO_0003761, EFO_0005658
Disease	Bradycardia	CYP2D6 POMC	1.12e-03	26	56	2	C0428977
Disease	Severe Congenital Microcephaly	ERCC6 DYNC1H1	1.59e-03	31	56	2	C3853041
Disease	Microlissencephaly	ERCC6 DYNC1H1	1.80e-03	33	56	2	C1956147

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPYMNHCWRHSRRRV	ZNF280A	436	P59817
ERWKAAYTRHLRPDM	CACNA1A	801	O00555
RRAMVLAHRGGYWTL	CFAP54	1621	Q96N23
PLRHSWQMPNGHYRR	CACNA1E	2271	Q15878
RWDRSHRYPAVHVYM	BTNL2	281	Q9UIR0
MSRGGSYPHLLWDVR	DCAF6	1	Q58WW2
VPLDWETYMHRIGRA	DDX20	386	Q9UHI6
YPMFPHHSRSLGRDW	ANGEL2	21	Q5VTE6
GDRVWRMPLFEHYTR	LAP3	426	P28838
FLSGYVSVPRRRMFW	ERCC6	656	P0DP91
HMDWPYGYRRLLRFS	LOXL4	571	Q96JB6
PSHRWMLRCYGSRRH	LILRA5	206	A6NI73
LGIEWMRRHLAPDYR	GATM	276	P50440
GWYHSMEAVRRAFRV	MMP15	156	P51511
FRREYWTIFHAMRHP	GPR50	301	Q13585
NYWLTMFRIRYIHRP	CLCN7	396	P51798
VARDVPRHPAAMSWY	FBXW5	56	Q969U6
MAVERALAIRAPHWY	PTGER3	151	P43115
KYVMGHFRWDRFGRR	POMC	76	P01189
WRGEFMPASRSEYHR	POLE	671	Q07864
RSRHMPWRTYRGAKV	NPBWR2	151	P48146
RCSYHLMRGERRPLW	EIF4E3	101	Q8N5X7
GIWYRMGRVPRNHDS	MVB12B	186	Q9H7P6
RLGRYRMPFAWTAVH	DOCK6	386	Q96HP0
QRLGQYRMPFAWAAR	DOCK9	516	Q9BZ29
DLMHRRQRWAARYPP	CYP2D6	21	P10635
RYMVQWPGGRILHRH	FAM120C	771	Q9NX05
YRLGMAARGHSWPCL	EBI3	66	Q14213
SRTPGRWDHQFYMRF	ITGA10	686	O75578
HYIYSPREMTRWVRG	DYNC1H1	2791	Q14204
VEQFWRFYSHMVRPG	EIF4E2	91	O60573
DRVFWLPHNMDFRGR	POLRMT	791	O00411
HWVPAEKMYYTHRRR	DYSF	1026	O75923
MIRFHSFYPWHTGRD	MIOX	216	Q9UGB7
ALSRYVGHLWMGRRP	MTX1	71	Q13505
HGGVDWMRKLAFRYR	EYA2	371	O00167
FRHQALWDRYMGTLR	FIBP	341	O43427
WREMPIRFADFGVLH	TARS3	506	A2RTX5
DRGKMRDLFTPHFRW	SVOP	301	Q8N4V2
GRRHVALRIAYMGWG	PUS3	61	Q9BZE2
MALWRAYQRALAAHP	MPV17	1	P39210
CRRWMQLGAFYPFSR	SI	646	P14410
LSGFMRHPRREMYWE	PGBD1	466	Q96JS3
RFGRSRIHEWGLFAM	SETD1A	1571	O15047
DLMHRHQRWAARYPP	CYP2D7	21	A0A087X1C5
HHMVSVVPSRYPRWF	ZSWIM5	781	Q9P217
QLRQEPWYHGRMSRR	SHC2	481	P98077
PWYHGRMSRRAAERM	SHC2	486	P98077
RGCIVIRYTAPWHMV	TMEM53	61	Q6P2H8
PHDRAVWRAMLARYV	SNRNP35	26	Q16560
DRPRDWYRRMFQQIH	SORBS3	141	O60504
LYPVSARHWFTMERL	ATP6AP1	331	Q15904
VWPYRMSRRRRYEGH	WDR25	456	Q64LD2
THKWMVYVRGSRREP	YEATS2	231	Q9ULM3
RFYFRNWHGMNPREP	TYK2	106	P29597
YFWRPKRMELSFGIH	MYO3A	816	Q8NEV4
YGGAEMRTQHWPIRL	MYORG	186	Q6NSJ0