Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CLCNKA CACNA1C KCNK7 CACNA1F

6.15e-05182244GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CLCNKA CACNA1C KCNK7 CACNA1F

6.42e-05184244GO:0022832
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1F

1.25e-0414242GO:0008331
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CLCNKA CACNA1C KCNK7 SLC18B1 CACNA1F SLC5A12

2.20e-04758246GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CLCNKA CACNA1C KCNK7 SLC18B1 CACNA1F SLC5A12

2.80e-04793246GO:0015075
GeneOntologyMolecularFunctiongated channel activity

CLCNKA CACNA1C KCNK7 CACNA1F

6.27e-04334244GO:0022836
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1C KCNK7 SLC18B1 CACNA1F SLC5A12

7.78e-04627245GO:0022890
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1C KCNK7 CACNA1F

7.78e-04152243GO:0022843
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1C KCNK7 SLC18B1 CACNA1F SLC5A12

1.01e-03664245GO:0008324
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CACNA1F

1.39e-0346242GO:0005245
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CLCNKA CACNA1C KCNK7 CACNA1F

2.03e-03459244GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1C KCNK7 CACNA1F SLC5A12

2.13e-03465244GO:0046873
GeneOntologyMolecularFunctiontransmembrane transporter activity

CLCNKA CACNA1C KCNK7 SLC18B1 CACNA1F SLC5A12

2.25e-031180246GO:0022857
GeneOntologyMolecularFunctionchannel activity

CLCNKA CACNA1C KCNK7 CACNA1F

3.30e-03525244GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CLCNKA CACNA1C KCNK7 CACNA1F

3.33e-03526244GO:0022803
GeneOntologyMolecularFunctiontransporter activity

CLCNKA CACNA1C KCNK7 SLC18B1 CACNA1F SLC5A12

3.51e-031289246GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1C KCNK7 CACNA1F

7.78e-03343243GO:0005261
GeneOntologyCellularComponentasymmetric, glutamatergic, excitatory synapse

PLXNA4 NLGN1

3.43e-0424242GO:0098985
GeneOntologyCellularComponentmonoatomic ion channel complex

CLCNKA CACNA1C KCNK7 CACNA1F

8.40e-04378244GO:0034702
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CACNA1F

1.27e-0346242GO:0005891
GeneOntologyCellularComponenttransmembrane transporter complex

CLCNKA CACNA1C KCNK7 CACNA1F

2.76e-03523244GO:1902495
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CACNA1F

3.16e-0373242GO:0034704
GeneOntologyCellularComponentdendritic shaft

CACNA1C NLGN1

3.24e-0374242GO:0043198
GeneOntologyCellularComponenttransporter complex

CLCNKA CACNA1C KCNK7 CACNA1F

3.31e-03550244GO:1990351
HumanPhenoAbnormal circulating unsaturated fatty acid concentration

CLCNKA PLA2G4A

9.65e-058102HP:0011022
HumanPhenoAbnormal circulating eicosanoid concentration

CLCNKA PLA2G4A

9.65e-058102HP:0030361
DomainCAC1F_C

CACNA1C CACNA1F

4.74e-063242PF16885
DomainCAC1F_C

CACNA1C CACNA1F

4.74e-063242IPR031688
DomainVDCC_L_a1su

CACNA1C CACNA1F

9.48e-064242IPR005446
DomainGPHH_dom

CACNA1C CACNA1F

3.31e-057242IPR031649
DomainVDCC_a1su_IQ

CACNA1C CACNA1F

3.31e-057242IPR014873
DomainCa_chan_IQ

CACNA1C CACNA1F

3.31e-057242SM01062
DomainCa_chan_IQ

CACNA1C CACNA1F

3.31e-057242PF08763
DomainGPHH

CACNA1C CACNA1F

3.31e-057242PF16905
DomainVDCCAlpha1

CACNA1C CACNA1F

7.08e-0510242IPR002077
DomainChannel_four-helix_dom

CACNA1C CACNA1F

2.42e-0357242IPR027359
Domain-

CACNA1C CACNA1F

2.42e-03572421.20.120.350
DomainIon_trans_dom

CACNA1C CACNA1F

9.34e-03114242IPR005821
DomainIon_trans

CACNA1C CACNA1F

9.34e-03114242PF00520
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1F

2.30e-056182M47762
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1C CACNA1F

1.39e-0414182M47692
PathwayKEGG_GNRH_SIGNALING_PATHWAY

CACNA1C PLA2G4A CACNA1F

2.69e-04101183M1979
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1F

3.83e-0423182M47666
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

CACNA1C PLA2G4A CACNA1F

3.95e-04115183M9387
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1C CACNA1F

4.54e-0425182M47948
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CLCNKA CACNA1C KCNK7 CACNA1F

2.44e-0613924416985003
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1C CACNA1F

2.74e-06424220937870
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1C CACNA1F

9.56e-06724212900400
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1C CACNA1F

1.64e-05924216382099
Pubmed

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

CACNA1C CACNA1F

2.50e-051124218809727
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1C CACNA1F

4.77e-051524224453333
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1C CACNA1F

4.77e-051524220188150
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1C CACNA1F

3.16e-043824230786075
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

CSDE1 PLA2G4A ANKRD17

4.34e-0421624331519766
Pubmed

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.

CSDE1 ANKRD17 RFC1

4.58e-0422024331822558
Pubmed

Large-scale concatenation cDNA sequencing.

CSDE1 CACNA1C NT5DC2 UBXN11

5.77e-045682449110174
Pubmed

A "double adaptor" method for improved shotgun library construction.

CSDE1 CACNA1C NT5DC2 UBXN11

6.00e-045742448619474
CytobandEnsembl 112 genes in cytogenetic band chr6q23

TAAR2 SLC18B1

1.77e-03119242chr6q23
CytobandEnsembl 112 genes in cytogenetic band chr4q13

AMBN ANKRD17

3.05e-03157242chr4q13
GeneFamilyCalcium voltage-gated channel subunits

CACNA1C CACNA1F

2.67e-0426172253
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

PLXNA4 AMBN CCNA1

2.85e-051112436a03fbeea8363a142c3c4d68e5aab106ce1bab31
ToppCellControl-Epithelial_alveolar-Mes-Like|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA2G4A CACNA1F UBXN11

3.25e-05116243df7609503782d8d7e4f31ed2a626916e5474d5bc
ToppCellControl-Epithelial_alveolar-Mes-Like-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA2G4A CACNA1F UBXN11

4.26e-05127243556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

CCNA1 FAM83F KCNK7

7.99e-0515724370fd6c46db4250c7de5c4686a9500689402737f6
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

CCNA1 FAM83F KCNK7

7.99e-05157243dd08dc19d434e94a194076c462ee273c682abf55
ToppCell10x5'-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

CCNA1 FAM83F NT5DC2

8.30e-05159243c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CCNA1 NT5DC2 HADH

1.07e-04173243a55f310c533432e9e26e400026a5b47245152976
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCNA1 NT5DC2 HADH

1.07e-041732439c7386bf0a899882c733f0b4921a96afde032a7d
ToppCellCTRL-Lymphoid-pDC|Lymphoid / Disease state, Lineage and Cell class

PLXNA4 PLA2G4A SLC18B1

1.08e-04174243ff4315e9fad198cc323fc987deb8652da137cf98
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCNKA NT5DC2 UBXN11

1.20e-041802439ef79a7c60227e352ac166c7274adb31f585f5ca
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCNKA NT5DC2 UBXN11

1.20e-04180243729f0d7af573c7796d8e28e6eec3af2fc0bd33a2
ToppCell10x5'-bone_marrow-Mast-Mast_cell_lympho|bone_marrow / Manually curated celltypes from each tissue

CCNA1 PLA2G4A NT5DC2

1.22e-0418124356fa77ae31f3b7de6e441a439c33a11353b6573a
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAM83F NLGN1 SLC5A12

1.24e-041822439d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellhematopoetic_progenitors-CD34+_MEP_2|World / Lineage and Cell class

CCNA1 FAM83F NT5DC2

1.24e-04182243a7e7aa10f14111a6c7ba22e0f1668dcaa124714d
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSDE1 ANKRD17 PLAGL2

1.30e-04185243d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSDE1 ANKRD17 PLAGL2

1.30e-04185243a2cae8c657e4f4d121476798e424876f7e247973
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RABEPK PLA2G4A NLGN1

1.32e-04186243e83718fabb057100835d3357df407f283d23fe16
ToppCellhematopoetic_progenitors-CD34+_MEP_2|hematopoetic_progenitors / Lineage and Cell class

CCNA1 FAM83F NT5DC2

1.43e-041912433b061dbc10918be7cbbd4453311d2c1ebf18c6b2
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

ANKRD17 NLGN1 SLC5A12

1.45e-04192243e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ComputationalNeighborhood of RAD54L

HADH GARS1 RFC1

3.05e-04105143MORF_RAD54L
DrugNiflumic Acid

CLCNKA PLA2G4A

6.38e-064242DB04552
DrugCinnarizine

CACNA1C CACNA1F

3.82e-059242DB00568
DrugNimodipine

CACNA1C CACNA1F

3.82e-059242DB00393
DrugMibefradil

CACNA1C CACNA1F

5.82e-0511242DB01388
DrugN-cyclopentyl-N-cyclobutylformamide

CCNA1 CACNA1C CACNA1F

7.72e-0579243CID005287890
DrugVerapamil

CACNA1C CACNA1F

1.27e-0416242DB00661
Drugnitrendipine

CACNA1C CACNA1F GARS1

1.47e-0498243CID000004507
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1F

3.80e-064242DOID:0060173 (implicated_via_orthology)
DiseaseAutistic Disorder

CSDE1 CACNA1C PLA2G4A NLGN1

5.53e-05261244C0004352
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1C CACNA1F

3.93e-0436242DOID:11723 (implicated_via_orthology)
DiseaseFEV change measurement, response to bronchodilator

PLXNA4 UBR3

1.02e-0358242EFO_0005921, GO_0097366

Protein segments in the cluster

PeptideGeneStartEntry
DPMAYGAMFPGFGGM

AMBN

271

Q9NP70
DMKGEVYPFGIVGMA

CSDE1

626

O75534
GYMDFPKVGGMPFSV

ANKRD17

2521

O75179
PKVGGMPFSVYGNAM

ANKRD17

2526

O75179
MGKHVYIFGGMTPAG

RABEPK

251

Q7Z6M1
VMYDGIMAYGGPFFP

CACNA1F

716

O60840
IMAYGGPFFPGMLVC

CACNA1F

721

O60840
TAMKLGAGYPMGPFE

HADH

246

Q16836
MAPLSPGGKAFCMVY

KCNK7

111

Q9Y2U2
VGGMEYSPGMVYIAP

PLXNA4

1216

Q9HCM2
GPKPVMVYIHGGSYM

NLGN1

211

Q8N2Q7
VMYDGIMAYGGPSFP

CACNA1C

711

Q13936
IMAYGGPSFPGMLVC

CACNA1C

716

Q13936
EKAYMKVMGGYDFPG

CAPN7

376

Q9Y6W3
METGFPAIMYPGSFI

CCNA1

1

P78396
SQGLIPFYMGFIPAM

FAM166A

276

Q6J272
PYEIGMAKYGTFMAP

PLA2G4A

351

P47712
GSMMCYSILGPFFPK

SLC18B1

46

Q6NT16
GELMRGYMTQFPTFP

RFC1

946

P35251
MFKTFIGPGGNMPGY

GARS1

281

P41250
VTGVGFYMPMGRIKG

FAM83F

226

Q8NEG4
TKAFPGMLPMGMYGA

PLAGL2

286

Q9UPG8
MPAGYFMPIFILGAA

CLCNKA

421

P51800
AGFFTPGSMMVGIYG

TAAR2

216

Q9P1P5
MSGFYGKGPSIKQFM

NT5DC2

171

Q9H857
FEPGGSMQQGMYTPK

UBR3

841

Q6ZT12
YFVMEIFATMPGLPG

SLC5A12

321

Q1EHB4
GIMMFDGPFQPFYDP

UBXN11

241

Q5T124