Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR2 RYR3

4.09e-064172GO:0005219
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR2 RYR3

1.02e-056172GO:0048763
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR2 RYR3

1.04e-0418172GO:0015278
GeneOntologyMolecularFunctiongated channel activity

CACNA1B ANO7 RYR2 RYR3

1.54e-04334174GO:0022836
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1B RYR2 RYR3

1.68e-04129173GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1B RYR2 RYR3

2.67e-04151173GO:0015085
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1B ATP13A5 ANO7 RYR2 RYR3 XPR1

2.96e-041180176GO:0022857
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR2 RYR3

3.13e-0431172GO:0099604
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1B ANO7 RYR2 RYR3 XPR1

3.29e-04758175GO:0015318
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR2 RYR3

3.55e-0433172GO:0005217
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1B ATP13A5 ANO7 RYR2 RYR3

4.05e-04793175GO:0015075
GeneOntologyMolecularFunctiontransporter activity

CACNA1B ATP13A5 ANO7 RYR2 RYR3 XPR1

4.77e-041289176GO:0005215
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1B ANO7 RYR2 RYR3

5.17e-04459174GO:0005216
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO7 RYR2 RYR3

5.47e-04193173GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

ANO7 RYR2 RYR3

5.81e-04197173GO:0022834
GeneOntologyMolecularFunctionchannel activity

CACNA1B ANO7 RYR2 RYR3

8.56e-04525174GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1B ANO7 RYR2 RYR3

8.62e-04526174GO:0022803
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1B ATP13A5 RYR2 RYR3

2.04e-03664174GO:0008324
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1B RYR2 RYR3

2.86e-03343173GO:0005261
GeneOntologyMolecularFunctioncalcium ion binding

CACNA1B CLEC4A RYR2 RYR3

3.16e-03749174GO:0005509
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

RYR2 RYR3

6.20e-03140172GO:0099094
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1B RYR2 RYR3

6.69e-03465173GO:0046873
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

BMP2K CERK DSTYK UAP1

7.05e-03938174GO:0016772
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

ANO7 XPR1

9.11e-03171172GO:0015103
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1B RYR2 RYR3

1.51e-02627173GO:0022890
GeneOntologyMolecularFunctioncalmodulin binding

RYR2 RYR3

1.60e-02230172GO:0005516
GeneOntologyBiologicalProcessinorganic ion homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3 XPR1

6.84e-06622176GO:0098771
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

IFNG CACNA1B CLEC4A ANO7 RYR2 RYR3 XPR1

8.73e-061017177GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

IFNG CACNA1B CLEC4A ATP13A5 ANO7 RYR2 RYR3

1.59e-051115177GO:0034220
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CACNA1B CLEC4A RYR2 RYR3

2.55e-05217174GO:0097553
GeneOntologyBiologicalProcesscellular response to caffeine

RYR2 RYR3

3.50e-0511172GO:0071313
GeneOntologyBiologicalProcessintracellular chemical homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3 XPR1

4.47e-05866176GO:0055082
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR2 RYR3

5.78e-0514172GO:0071415
GeneOntologyBiologicalProcessmonoatomic ion transport

IFNG CACNA1B CLEC4A ATP13A5 ANO7 RYR2 RYR3

6.16e-051374177GO:0006811
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

IFNG CACNA1B CLEC4A ATP13A5 RYR2 RYR3

7.16e-05942176GO:0098655
GeneOntologyBiologicalProcesscellular homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3 XPR1

8.97e-05981176GO:0019725
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3

1.03e-04611175GO:0030003
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3

1.12e-04622175GO:0006873
GeneOntologyBiologicalProcessresponse to caffeine

RYR2 RYR3

1.33e-0421172GO:0031000
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CLEC4A ATP13A5 RYR2 RYR3

1.80e-04359174GO:0006874
GeneOntologyBiologicalProcessnegative regulation of cytosolic calcium ion concentration

RYR2 RYR3

1.90e-0425172GO:0051481
GeneOntologyBiologicalProcessresponse to magnesium ion

RYR2 RYR3

1.90e-0425172GO:0032026
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3

2.02e-04705175GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3

2.19e-04717175GO:0050801
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

CLEC4A RYR2 RYR3

2.20e-04146173GO:0051209
GeneOntologyBiologicalProcessmonoatomic cation transport

IFNG CACNA1B CLEC4A ATP13A5 RYR2 RYR3

2.23e-041157176GO:0006812
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

CLEC4A RYR2 RYR3

2.24e-04147173GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

CLEC4A RYR2 RYR3

2.33e-04149173GO:0051282
GeneOntologyBiologicalProcesscalcium ion homeostasis

CLEC4A ATP13A5 RYR2 RYR3

2.44e-04389174GO:0055074
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

CACNA1B CLEC4A RYR2 RYR3

2.51e-04392174GO:0070588
GeneOntologyBiologicalProcesssequestering of calcium ion

CLEC4A RYR2 RYR3

2.52e-04153173GO:0051208
GeneOntologyBiologicalProcessresponse to calcium ion

CPNE5 RYR2 RYR3

2.93e-04161173GO:0051592
GeneOntologyBiologicalProcessregulation of the force of heart contraction

IFNG RYR2

3.33e-0433172GO:0002026
GeneOntologyBiologicalProcesschemical homeostasis

IFNG CLEC4A ATP13A5 RYR2 RYR3 XPR1

3.38e-041249176GO:0048878
GeneOntologyBiologicalProcesspositive regulation of cation transmembrane transport

IFNG CLEC4A RYR2

3.68e-04174173GO:1904064
GeneOntologyBiologicalProcessCD8-positive, alpha-beta T cell activation

IFNG CLEC4A

3.96e-0436172GO:0036037
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

RYR2 RYR3

4.19e-0437172GO:0014808
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

RYR2 RYR3

4.65e-0439172GO:1903514
GeneOntologyBiologicalProcesscellular response to alkaloid

RYR2 RYR3

4.90e-0440172GO:0071312
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transmembrane transport

IFNG CLEC4A RYR2

4.90e-04192173GO:0034767
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

RYR2 RYR3

5.93e-0444172GO:0070296
GeneOntologyBiologicalProcessregulation of metal ion transport

IFNG CACNA1B CLEC4A RYR2

5.99e-04493174GO:0010959
GeneOntologyBiologicalProcesscalcium ion transport

CACNA1B CLEC4A RYR2 RYR3

6.75e-04509174GO:0006816
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

IFNG CACNA1B CLEC4A RYR2 RYR3

6.97e-04922175GO:0098662
GeneOntologyBiologicalProcessmetal ion transport

IFNG CACNA1B CLEC4A RYR2 RYR3

1.01e-031000175GO:0030001
GeneOntologyBiologicalProcessregulation of heart contraction

IFNG CACNA1B RYR2

1.04e-03249173GO:0008016
GeneOntologyBiologicalProcessregulation of monoatomic ion transport

IFNG CACNA1B CLEC4A RYR2

1.08e-03577174GO:0043269
GeneOntologyBiologicalProcessmaintenance of location in cell

CLEC4A RYR2 RYR3

1.17e-03259173GO:0051651
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transport

IFNG CLEC4A RYR2

1.26e-03266173GO:0043270
GeneOntologyBiologicalProcesspositive regulation of transmembrane transport

IFNG CLEC4A RYR2

1.36e-03273173GO:0034764
GeneOntologyBiologicalProcessheart contraction

IFNG CACNA1B RYR2

1.75e-03298173GO:0060047
GeneOntologyBiologicalProcessheart process

IFNG CACNA1B RYR2

1.94e-03309173GO:0003015
GeneOntologyBiologicalProcessregulation of action potential

IFNG RYR2

1.99e-0381172GO:0098900
GeneOntologyBiologicalProcessregulation of calcium ion transport

CACNA1B CLEC4A RYR2

2.20e-03323173GO:0051924
GeneOntologyBiologicalProcessregulation of blood circulation

IFNG CACNA1B RYR2

2.26e-03326173GO:1903522
GeneOntologyBiologicalProcesscellular response to calcium ion

CPNE5 RYR3

2.35e-0388172GO:0071277
GeneOntologyBiologicalProcesspositive regulation of ion transmembrane transporter activity

IFNG RYR2

2.84e-0397172GO:0032414
GeneOntologyBiologicalProcessregulation of release of sequestered calcium ion into cytosol

CLEC4A RYR2

2.90e-0398172GO:0051279
GeneOntologyBiologicalProcesspositive regulation of transporter activity

IFNG RYR2

3.45e-03107172GO:0032411
GeneOntologyBiologicalProcessregulation of monoatomic cation transmembrane transport

IFNG CLEC4A RYR2

3.48e-03380173GO:1904062
GeneOntologyCellularComponentcalcium channel complex

CACNA1B RYR2 RYR3

2.68e-0573173GO:0034704
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

RYR2 RYR3

6.04e-0445172GO:0033017
GeneOntologyCellularComponentsmooth endoplasmic reticulum

RYR2 RYR3

6.31e-0446172GO:0005790
GeneOntologyCellularComponentcation channel complex

CACNA1B RYR2 RYR3

8.49e-04235173GO:0034703
GeneOntologyCellularComponentsarcoplasmic reticulum

RYR2 RYR3

2.29e-0388172GO:0016529
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1B RYR2 RYR3

3.30e-03378173GO:0034702
GeneOntologyCellularComponentsarcoplasm

RYR2 RYR3

3.80e-03114172GO:0016528
DomainRR_TM4-6

RYR2 RYR3

2.34e-063172PF06459
DomainRyanrecept_TM4-6

RYR2 RYR3

2.34e-063172IPR009460
DomainRyR

RYR2 RYR3

2.34e-063172PF02026
DomainRyanodine_rcpt

RYR2 RYR3

2.34e-063172IPR003032
DomainRyan_recept

RYR2 RYR3

2.34e-063172IPR013333
DomainRIH_assoc

RYR2 RYR3

1.17e-056172PF08454
DomainRIH_assoc-dom

RYR2 RYR3

1.17e-056172IPR013662
DomainIns145_P3_rec

RYR2 RYR3

1.17e-056172PF08709
DomainRYDR_ITPR

RYR2 RYR3

1.17e-056172PF01365
DomainRIH_dom

RYR2 RYR3

1.17e-056172IPR000699
DomainIns145_P3_rcpt

RYR2 RYR3

1.17e-056172IPR014821
DomainRyanodine_recept-rel

RYR2 RYR3

1.17e-056172IPR015925
Domain-

RYR2 RYR3

1.17e-0561721.25.10.30
DomainMIR

RYR2 RYR3

3.49e-0510172PS50919
DomainMIR

RYR2 RYR3

3.49e-0510172PF02815
DomainMIR

RYR2 RYR3

3.49e-0510172SM00472
DomainMIR_motif

RYR2 RYR3

3.49e-0510172IPR016093
DomainIon_trans_dom

CACNA1B RYR2 RYR3

1.41e-04114173IPR005821
DomainIon_trans

CACNA1B RYR2 RYR3

1.41e-04114173PF00520
DomainEF_HAND_2

CACNA1B RYR2 RYR3

1.12e-03231173PS50222
DomainEF_hand_dom

CACNA1B RYR2 RYR3

1.13e-03232173IPR002048
DomainEF-hand-dom_pair

CACNA1B RYR2 RYR3

2.08e-03287173IPR011992
DomainSPRY

RYR2 RYR3

2.79e-0387172SM00449
DomainSPRY

RYR2 RYR3

3.24e-0394172PF00622
DomainSPRY_dom

RYR2 RYR3

3.24e-0394172IPR003877
DomainB30.2/SPRY

RYR2 RYR3

3.31e-0395172IPR001870
DomainB302_SPRY

RYR2 RYR3

3.31e-0395172PS50188
DomainEF-hand_1

RYR2 RYR3

8.26e-03152172PF00036
DomainConA-like_dom

RYR2 RYR3

1.66e-02219172IPR013320
Domain-

RYR2 RYR3

2.30e-022611721.10.238.10
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1B RYR2 RYR3

1.01e-0711133M47958
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP13A5 ANO7 RYR2 RYR3

1.54e-05176134MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP13A5 ANO7 RYR2 RYR3

1.79e-05183134M997
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR2 RYR3

6.09e-0513132M39589
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO7 RYR2 RYR3

9.13e-0599133MM14910
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO7 RYR2 RYR3

1.12e-04106133M27200
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR2 RYR3

1.33e-0419132M47760
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1B RYR2 RYR3

2.94e-04147133MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1B RYR2 RYR3

3.18e-04151133M39329
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1B RYR2 RYR3

5.16e-04178133M2890
PathwayREACTOME_ION_HOMEOSTASIS

RYR2 RYR3

1.09e-0354132MM15202
PathwayREACTOME_ION_HOMEOSTASIS

RYR2 RYR3

1.09e-0354132M27460
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ATP13A5 ANO7 RYR2 RYR3

2.72e-03681134MM14985
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

2.25e-07217221531043
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

2.25e-07217216678258
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

2.25e-0721728898078
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

2.25e-07217214550562
Pubmed

Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.

RYR2 RYR3

2.25e-07217214985349
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR2 RYR3

6.74e-07317218403125
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR2 RYR3

6.74e-07317218434746
Pubmed

Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.

RYR2 RYR3

6.74e-07317229730765
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR2 RYR3

6.74e-0731729204703
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR2 RYR3

6.74e-0731727876312
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR2 RYR3

6.74e-07317221881589
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR2 RYR3

6.74e-07317212213830
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR2 RYR3

6.74e-0731729242641
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR2 RYR3

6.74e-07317222948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR2 RYR3

6.74e-07317210788707
Pubmed

RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.

RYR2 RYR3

6.74e-07317215024040
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR2 RYR3

6.74e-07317225239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR2 RYR3

6.74e-0731727621815
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR2 RYR3

6.74e-07317218643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR2 RYR3

6.74e-07317211159936
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR2 RYR3

6.74e-07317210473538
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR2 RYR3

6.74e-0731727959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR2 RYR3

6.74e-0731724600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR2 RYR3

6.74e-0731727635066
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1B RYR2 RYR3

8.10e-073817330786075
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR2 RYR3

1.35e-06417218206662
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR2 RYR3

1.35e-06417223413940
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR2 RYR3

1.35e-0641729384575
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR2 RYR3

1.35e-0641729607712
Pubmed

DCIR maintains bone homeostasis by regulating IFN-γ production in T cells.

IFNG CLEC4A

1.35e-06417225926676
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR2 RYR3

1.35e-06417223482488
Pubmed

Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.

RYR2 RYR3

2.25e-06517233060591
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR2 RYR3

2.25e-06517223918386
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR2 RYR3

2.25e-06517219011160
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR2 RYR3

3.37e-06617219549818
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR2 RYR3

3.37e-06617226025922
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR2 RYR3

3.37e-06617223463619
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR2 RYR3

3.37e-06617214592808
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR2 RYR3

3.37e-06617220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR2 RYR3

3.37e-06617225966694
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR2 RYR3

3.37e-06617219009018
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR2 RYR3

3.37e-06617216844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR2 RYR3

4.72e-06717211860456
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR2 RYR3

4.72e-06717220962236
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR2 RYR3

6.29e-06817219033399
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR2 RYR3

6.29e-06817211784029
Pubmed

Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.

RYR2 XPR1

8.08e-06917223829686
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

RYR2 RYR3

1.48e-051217219095005
Pubmed

A comprehensive resource of interacting protein regions for refining human transcription factor networks.

CACNA1B RYR2 RYR3

1.05e-0419117320195357
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR2 RYR3

6.61e-07392287
GeneFamilyEF-hand domain containing

CACNA1B RYR2 RYR3

1.40e-0421993863
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B ATP13A5 RYR2 RYR3

3.54e-07160174c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B ATP13A5 RYR2 RYR3

3.54e-0716017425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

DCUN1D2 ANO7 CFAP54

2.20e-051461735b2608b56204dda9a773988f42ff00a9fa743a39
ToppCellfacs-Heart-RA-24m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE5 RYR2 RYR3

2.73e-051571739021900d9b1a71210c9c414a9d165eaf399eb607
ToppCellfacs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE5 RYR2 RYR3

2.73e-05157173c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CPNE5 BMP2K RYR3

3.17e-0516517337615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CPNE5 BMP2K RYR3

3.17e-05165173640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CPNE5 BMP2K RYR3

3.17e-05165173f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellASK428-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

CPNE5 BMP2K DSTYK

3.35e-05168173c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

CPNE5 BMP2K RYR3

3.41e-05169173fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A5 RYR2 RYR3

3.41e-0516917312bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

CPNE5 BMP2K RYR3

3.47e-05170173c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellControl-CD4+_T_activated|World / Disease group and Cell class

CPNE5 CLEC4A CFAP54

3.65e-0517317312f8e4276b290bb388a56de4c8d8dd60415b2f63
ToppCellControl-CD4+_T_activated|Control / Disease group and Cell class

CPNE5 CLEC4A CFAP54

3.71e-051741732b683e81b315ad22555314433aed5681feb48da8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CPNE5 BMP2K CACNA1B

3.91e-0517717337d1abe1a9d8f2b8f4d146bbf1db94104eab6593
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Mast_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP2K CFAP54 RYR3

3.97e-05178173c6704fcd21a9d2fe45679a1d998f04213b3bf224
ToppCellCOPD-Lymphoid-B_Plasma|Lymphoid / Disease state, Lineage and Cell class

CPNE5 ANO7 CFAP54

4.25e-0518217319db653fe04c5e2957eea1f4893b1c1fca4ddcbd
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG CPNE5 RYR2

4.53e-051861737278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellB_cells-Plasma_cells_and_plasmablasts|World / Immune cells in Kidney/Urine in Lupus Nephritis

CPNE5 UAP1 CFAP54

4.60e-051871739325cadd5f2c667d526696899e7aa36a98226d4b
ToppCellfacs-Heart-RA-24m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE5 RYR2 RYR3

4.75e-05189173e4efbb0733b382f4c855f6653dcddf36e0f8df28
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE5 RYR2 RYR3

4.75e-05189173b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE5 RYR2 RYR3

4.75e-05189173e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

CPNE5 RYR2 XPR1

4.83e-05190173fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellBronchial-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CPNE5 BMP2K RYR3

5.37e-05197173bed8a9b73af5caee51b1232b31c24a59353658df
ToppCellBronchial-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CPNE5 BMP2K RYR3

5.37e-05197173b7d5073d44aa1e2cb83ea8d8104c5ed662665755
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgG_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

CPNE5 UAP1 CFAP54

5.37e-05197173b754fad4f3caae6de95df901fd96ea8697fe41b1
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

UAP1 RYR3 XPR1

5.45e-05198173399760b6b6fef8639ded53b14f251b9fce600e81
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

IFNG CPNE5

1.69e-0451172d43b0813f7c456f8fff77197fbbaef2f4d160563
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CLEC4A DSTYK

3.02e-0468172f1cbc6d72489272c1eb6200f64b8b6444719acda
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-MAIT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IFNG CPNE5

8.01e-0411117258a1536cf63568ffc985baefa495af659dd9ba88
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MMP26 CACNA1B

1.06e-0312817291072ca56bce2c552a95edd67e17f43d8cc1de95
ToppCellLV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

RYR2 XPR1

1.10e-03130172a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RYR2 RYR3

1.13e-0313217202491930097b75aaeedab9e8200711b0dc610944
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-2|TCGA-Stomach / Sample_Type by Project: Shred V9

TEX264 ATP13A5

1.15e-031331722d9e0a29eb205a5c2c8afe2e944115ab40b22afe
ToppCellControl-B_memory-6|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CPNE5 CACNA1B

1.20e-0313617294f23bef50c0beb54ed39b1a4b340f7aec4e75cd
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell|343B / Donor, Lineage, Cell class and subclass (all cells)

IFNG CPNE5

1.20e-03136172b4a934feea46eeb10d407d1545bd225173078792
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|343B / Donor, Lineage, Cell class and subclass (all cells)

IFNG CPNE5

1.21e-03137172885e4cfc237eca1fa2eb1f2fd8d84f151e21ecfa
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B ATP13A5

1.36e-0314517296712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellChildren_(3_yrs)-Immune-mast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

BMP2K RYR3

1.38e-03146172f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MMP26 CACNA1B

1.42e-03148172d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_memory-B_memory-6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CPNE5 CACNA1B

1.43e-031491722cd860b96ed4be4d26844085d464961c1418054a
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

IFNG CPNE5

1.43e-031491722a7f71da51c85e04de2123164914122480e60d66
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DCUN1D2 CFAP54

1.45e-03150172b6f1fc62d08199fed6156c7cd32f66d9926531b5
ToppCellChildren_(3_yrs)-Immune-mast_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

BMP2K RYR3

1.47e-03151172bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCell368C-Myeloid-Mast_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

BMP2K CFAP54

1.49e-03152172faf30245a1690aaa27c7be0832797c340e4af4d7
ToppCell368C-Myeloid-Mast_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

BMP2K CFAP54

1.49e-03152172519c9ed05fdaf420e42147ffae1dc05a7f86fdd4
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DCUN1D2 ANO7

1.51e-031531729f0607a88d5f8a2c128a2ff64dfbc986212f13b2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPNE5 CFAP54

1.51e-031531723724dd498b982be693ddff9cea7671863acf3ff8
ToppCellControl-Myeloid-Neutrophils-Neutrophils|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CPNE5 CLEC4A

1.51e-03153172e3630f2b10f33092a3b6a63dba3a39fbdecbc7bd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPNE5 CFAP54

1.51e-03153172d810fc5aff28449ce79b4148558b260878a2c696
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNG TEX264

1.51e-031531720727dc70e16345645063c586d744bc4ac1710526
ToppCellControl-Myeloid-Neutrophils|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CPNE5 CLEC4A

1.51e-03153172c33d63b2d1a220bc428e776b157b23faa43ea8ca
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

RYR2 RYR3

1.51e-03153172ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCellIIH-CD8-exh_CD4|IIH / Condition, Cell_class and T cell subcluster

IFNG TEX264

1.53e-03154172a2f51a3c5455fe2483e438375ea856afce8262fe
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

BMP2K RYR3

1.57e-03156172159504d43421ee83b9ab484816333ae549c9c2fd
ToppCellPND03-Immune-Immune_Myeloid-DC-maDC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP2K UAP1

1.57e-03156172095281ea78aefa0ee638191a03f8d6f62a86a9ff
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

BMP2K RYR3

1.57e-03156172bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellPND03-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP2K UAP1

1.57e-0315617229b04143f71a0ecc600ac670abd1d521bee55fe7
ToppCellChildren_(3_yrs)-Immune-mast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

BMP2K RYR3

1.59e-03157172ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNG UAP1

1.63e-031591727c2f70a7cba880115ccd676fb6c5f18488a5b74f
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1B RYR2

1.63e-031591725335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CPNE5 RYR3

1.65e-03160172f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CPNE5 BMP2K

1.65e-03160172fe9970c160159b35f6599ed13c89cfb49264d554
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

RYR2 RYR3

1.67e-0316117264891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCellHealthy_Control-Myeloid-Macrophages-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

IFNG RYR2

1.67e-03161172d0482666479530cd2fd0d229cbb59a1d79839477
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNG UAP1

1.67e-03161172bf4bfb416cb6ef43fc8cf0ffc2d7f0b6b42ab4da
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CPNE5 RYR3

1.67e-03161172ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1B ATP13A5

1.69e-03162172bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG CFAP54

1.69e-03162172b5b2cdbcc5bbfab52cc7d8a5504d34bb2e73771a
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG CFAP54

1.69e-031621724f9cf67b4b00b1cf78eeb9be1c701d535021a61d
ToppCellfacs-Kidney-nan-3m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG RYR3

1.71e-03163172385b24e18df5ef92108483de312d6c85a1e6d145
ToppCellASK428-Immune-Mast_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

CPNE5 BMP2K

1.71e-03163172569ca0e8ce307f258910b0c75c498009a9651e6e
ToppCellfacs-Kidney-nan-3m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG RYR3

1.71e-031631728004cc0b3428be08b89957b563cd8799f822d931
ToppCellB_cells-ABCs|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

CPNE5 BMP2K

1.73e-03164172f45013706a917f0f0d69c23f288128f252cd60c7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BMP2K RYR3

1.73e-031641722c48c6e4eeee845f0563982d0bfa2a176ca5ef61
ToppCellfacs-Marrow-KLS-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG RYR3

1.73e-03164172d2b5f51af7fcffddebe997ee302bacbd85d76852
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MMP26 CACNA1B

1.73e-03164172be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellPND14-Immune-Immune_Myeloid-DC-maDC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP2K UAP1

1.75e-031651721c3709ac9f96ace1f3b28e1f2f15b4a8d65885ca
ToppCellfacs-Kidney-nan-3m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG RYR3

1.75e-03165172ba041deb0d9c187f251493ccd4794b5f09abd5aa
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B RYR2

1.75e-031651726d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B RYR2

1.75e-0316517284f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCellPND14-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP2K UAP1

1.75e-03165172fbc7d97e6f30975d35c76a7c97947a34cf5975d2
ToppCellcontrol-Plasmablast|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CPNE5 UAP1

1.75e-0316517261063e0ce61bc92d5d1093be8279af03f650720b
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP26 CLEC4A

1.77e-0316617283d0c26ccee605df6b04bbca31661bf4ff4f22ba
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CPNE5 RYR2

1.80e-031671726a03d16165e0b003092c39972928981abd4a75aa
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE5 ANO7

1.80e-0316717202c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP54 RYR3

1.84e-0316917216c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCellmild_COVID-19_(asymptomatic)-RBC|World / disease group, cell group and cell class (v2)

IFNG CPNE5

1.84e-031691722bda6ab3f32e05cb7daf91eb7c39b4fcc9ae91bb
ToppCellmetastatic_Lymph_Node-T/NK_cells-Exhausted_Tfh|metastatic_Lymph_Node / Location, Cell class and cell subclass

IFNG RYR2

1.84e-03169172ad9054ee09033b648a76baf1b2ec4a6ab1394bde
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

MMP26 CACNA1B

1.84e-03169172b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellCOVID-19-lung-MAST|lung / Disease (COVID-19 only), tissue and cell type

BMP2K RYR3

1.86e-03170172e90f18e5462381b38e918442b38b1c8105291908
ToppCellfacs-Brain_Myeloid-Striatum-24m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG CPNE5

1.86e-03170172ca88dc0b7a6960facb7c4d3c0f4795431a0a43d2
ToppCellfacs-Brain_Myeloid-Striatum-24m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG CPNE5

1.86e-03170172b6882665a27c78a63f3b4a2a8806c8438a98e407
ToppCellfacs-Brain_Myeloid-Striatum-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG CPNE5

1.86e-03170172626c12b9a51218f72ee32afb5fd5d4b075025d75
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP26 CACNA1B

1.86e-031701726a98f47f8c2b5b15e09169bd82eff1e6bf76e5a6
ToppCellfacs-Brain_Myeloid-Striatum-24m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFNG CPNE5

1.86e-0317017231daac8696ae8c021c0302d3b30dd8194054b3e7
ToppCellBronchial_Brush-Immune-B_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

CPNE5 DCUN1D2

1.86e-0317017253e9372cb06a2dc5c8ecb3f9af42f3c23da96431
ToppCellnormal-na-Lymphocytic_B-B_plasma-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

CPNE5 UAP1

1.86e-03170172c5b87974dfddf9780051f7f5693eeeb0c606a3fe
ToppCell368C-Lymphocytic-ILC|368C / Donor, Lineage, Cell class and subclass (all cells)

IFNG CPNE5

1.88e-031711723b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE5 RYR3

1.88e-0317117282de2885c8ce4fb7776da6a0207b3355c0910121
DrugAC1MW7VF

IFNG RYR2 RYR3

3.33e-0719173CID000414699
Drug2-hydroxyheptanoic acid

RYR2 RYR3

1.57e-063172CID002750949
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR2 RYR3

1.57e-063172CID005748312
Drug8N3-cADPR

RYR2 RYR3

1.57e-063172CID000127713
Drug2-hydroxycarbazole

RYR2 RYR3

1.57e-063172CID000093551
Drugaminodantrolene

RYR2 RYR3

1.57e-063172CID009570289
Drug1,1'-diheptyl-4,4'-bipyridinium

IFNG RYR3

1.57e-063172CID000080262
Drugcis-diammineplatinum(II

RYR2 RYR3

1.57e-063172CID000159790
DrugCNS 1145

CACNA1B RYR2 RYR3

1.86e-0633173CID000190902
DrugIHC-64

CACNA1B RYR2 RYR3

1.86e-0633173CID000162753
DrugSC 38249

RYR2 RYR3

3.15e-064172CID000134834
DrugAC1L1U7A

RYR2 RYR3

3.15e-064172CID000035682
DrugPCB74

RYR2 RYR3

3.15e-064172CID000036218
Drug148504-47-6

RYR2 RYR3

3.15e-064172CID006444275
DrugDantrolene-13C3

IFNG CACNA1B RYR2 RYR3

3.52e-06145174CID000002951
DrugDantrolene

IFNG RYR2 RYR3

3.62e-0641173ctd:D003620
Druglindane

IFNG CACNA1B RYR2 RYR3

4.47e-06154174CID000000727
DrugAC1L9KQO

IFNG RYR2 RYR3

6.24e-0649173CID000447335
DrugAC1O528X

RYR2 RYR3

7.86e-066172CID006475857
DrugNSC114784

RYR2 RYR3

7.86e-066172CID000419425
DrugMBED

RYR2 RYR3

7.86e-066172CID000129958
Drugchloro-m-cresol

RYR2 RYR3

7.86e-066172CID000012008
DrugCinildipine

CACNA1B RYR2 RYR3

9.35e-0656173CID000002752
DrugAzumoleno

RYR2 RYR3

1.10e-057172CID000056259
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR2 RYR3

1.10e-057172CID009547999
DrugBr2BAPTA

RYR2 RYR3

1.10e-057172CID003081001
Drugnilvadipine

CACNA1B RYR2 RYR3

1.15e-0560173CID000004494
DrugIAA-94

CACNA1B RYR2 RYR3

1.21e-0561173CID000003667
Druglercanidipine

CACNA1B RYR2 RYR3

1.34e-0563173CID000065866
Druggallopamil

CACNA1B RYR2 RYR3

1.61e-0567173CID000001234
DrugAC1L2AC7

CACNA1B RYR2 RYR3

1.76e-0569173CID000068733
DrugCAS 298-57-7

CACNA1B RYR2 RYR3

2.08e-0573173CID000002761
Drugethosuximide

CACNA1B RYR2 RYR3

2.17e-0574173CID000003291
DrugCalcium

IFNG CACNA1B CERK RYR2 RYR3

2.33e-05493175ctd:D002118
DrugPCB 95

RYR2 RYR3

2.35e-0510172CID000038012
Drugnisoldipine

CACNA1B RYR2 RYR3

2.54e-0578173CID000004499
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1B RYR2 RYR3

2.64e-0579173CID005287890
DrugR 478

RYR2 RYR3

2.87e-0511172CID000084223
Drug8-amino-cADPR

RYR2 RYR3

2.87e-0511172CID003081323
DrugPCB 66

RYR2 RYR3

2.87e-0511172CID000036185
DrugXeC compound

CACNA1B RYR2 RYR3

3.17e-0584173CID000005701
DrugRyanodine

RYR2 RYR3

3.45e-0512172ctd:D012433
Drugmanidipine

CACNA1B RYR2 RYR3

4.59e-0595173CID000004008
Drugnoradrealine

IFNG MMP26 CACNA1B RYR2 RYR3

4.86e-05575175CID000000951
Drugisotetrandrine

CACNA1B RYR2 RYR3

4.88e-0597173CID000005422
Drugnitrendipine

CACNA1B RYR2 RYR3

5.03e-0598173CID000004507
Drugisradipine

CACNA1B RYR2 RYR3

5.35e-05100173CID000003784
DrugFPL 64176

RYR2 RYR3

5.48e-0515172CID000003423
DrugGvapspat amide

RYR2 RYR3

5.48e-0515172CID000125015
DrugAC1O3MDH

IFNG RYR2 RYR3

5.67e-05102173CID006332158
Drugloperamide

CACNA1B RYR2 RYR3

6.18e-05105173CID000003954
Drug8-bromoguanosine 3',5'-cyclic monophosphate

IFNG CACNA1B RYR2 RYR3

6.80e-05308174CID000001915
Drugkazinol B

RYR2 RYR3

7.09e-0517172CID000480869
Drughalothane

IFNG CACNA1B RYR2 RYR3

7.33e-05314174CID000003562
Drugmethylcoumarin

RYR2 RYR3

7.97e-0518172CID000007092
Druglamotrigine

CACNA1B RYR2 RYR3

8.32e-05116173CID000003878
DrugAC1NBU2S

CACNA1B RYR2 RYR3

8.53e-05117173CID004473765
DrugAC1L380G

RYR2 RYR3

8.91e-0519172CID000084698
Drugbepridil

CACNA1B RYR2 RYR3

1.06e-04126173CID000002351
Drugpimozide

CACNA1B RYR2 RYR3

1.09e-04127173CID000016362
Drugindo-1/AM

RYR2 RYR3

1.09e-0421172CID000123918
Drugebselen

IFNG RYR2 RYR3

1.19e-04131173CID000003194
Drugradon

IFNG CLEC4A

1.32e-0423172CID000024857
Druglanthanum

CACNA1B RYR2 RYR3

1.33e-04136173CID000023926
Drugperoxynitrite

IFNG MMP26 RYR2 RYR3

1.42e-04373174CID000104806
Drugzaprinast

IFNG RYR2 RYR3

1.48e-04141173CID000005722
DrugT0702

RYR2 RYR3

1.56e-0425172CID000005908
Drugnimodipine

CACNA1B RYR2 RYR3

1.61e-04145173CID000004497
Drugnicardipine

CACNA1B RYR2 RYR3

1.61e-04145173CID000004473
Drug(2S,3R)-Sphingosine

IFNG CERK RYR2 RYR3

1.67e-04389174CID000001104
Drugcobalt-60

IFNG CACNA1B RYR2 RYR3

1.69e-04390174CID000061492
DrugBay K 8644

CACNA1B RYR2 RYR3

1.78e-04150173CID000002303
Drugaldosterone

MMP26 CACNA1B RYR2 RYR3

1.81e-04397174CID000005839
Drugprocaine

CACNA1B RYR2 RYR3

1.89e-04153173CID000004914
DrugVirginiamycin S1

IFNG CACNA1B

1.96e-0428172CID000122731
Drug2,4-xylidinothiazoline

RYR2 RYR3

2.25e-0430172CID000099296
DrugLOPAC

RYR2 RYR3

2.25e-0430172CID000062696
Drugcyclophorine

IFNG CACNA1B RYR2 RYR3

2.37e-04426174CID000002909
DrugM-HN

RYR2 RYR3

2.41e-0431172CID000015450
Druggabapentin

CACNA1B RYR2 RYR3

2.53e-04169173CID000003446
Drugfelodipine

CACNA1B RYR2 RYR3

2.53e-04169173CID000003333
DrugM3/M4

RYR2 RYR3

2.57e-0432172CID000486507
Druglavendustin A

CACNA1B RYR2 RYR3

2.62e-04171173CID000003894
Drugriluzole

CACNA1B RYR2 RYR3

2.76e-04174173CID000005070
Drugpapaverine

CACNA1B RYR2 RYR3

2.85e-04176173CID000004680
DrugAC1Q6L57

BMP2K CACNA1B

2.90e-0434172CID000090740
DrugNSC7524

CACNA1B RYR2 RYR3

3.15e-04182173CID000005657
Drug1,2-dichlorohexafluorocyclobutane

RYR2 RYR3

3.44e-0437172CID000009643
Drug4-chloro-m-cresol

RYR2 RYR3

3.44e-0437172CID000001732
Drugmag-fura-2

RYR2 RYR3

3.44e-0437172CID000123839
DrugApigenin [520-36-5]; Up 200; 14.8uM; MCF7; HT_HG-U133A

DCUN1D2 CLEC4A RYR2

3.57e-041901733257_UP
Drugbaclofen

CACNA1B RYR2 RYR3

3.62e-04191173CID000002284
DrugNSC759576

CACNA1B RYR2 RYR3

3.62e-04191173CID000003075
DrugAC1L98DX

RYR2 RYR3

3.63e-0438172CID000439957
Drugdihydropyridine

CACNA1B RYR2 RYR3

3.74e-04193173CID000104822
DrugSisomicin sulfate [53179-09-2]; Down 200; 2.8uM; MCF7; HT_HG-U133A

BMP2K DSTYK RYR2

3.79e-041941734132_DN
DrugAlexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; MCF7; HT_HG-U133A

CERK DSTYK RYR2

3.79e-041941734721_DN
DrugNAADP

RYR2 RYR3

3.83e-0439172CID000123952
DrugAmethopterin (R,S) [59-05-2]; Down 200; 8.8uM; PC3; HT_HG-U133A

BMP2K DSTYK RYR2

3.85e-041951736654_DN
DrugChrysin [480-40-0]; Up 200; 15.8uM; HL60; HT_HG-U133A

IFNG BMP2K CLEC4A

3.91e-041961733106_UP
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR2 RYR3

9.37e-073172DOID:8545 (implicated_via_orthology)
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR2 RYR3

9.37e-073172DOID:3529 (implicated_via_orthology)
Diseaselanguage measurement

MMP26 ATP13A5 CFAP54

5.94e-05134173EFO_0007797
DiseaseAllergic Reaction

IFNG CLEC4A

5.98e-0463172C1527304
DiseaseHypersensitivity

IFNG CLEC4A

6.17e-0464172C0020517
Diseasepulmonary hypertension (biomarker_via_orthology)

RYR2 RYR3

9.61e-0480172DOID:6432 (biomarker_via_orthology)
DiseaseMalignant mesothelioma

IFNG RYR2

1.77e-03109172C0345967

Protein segments in the cluster

PeptideGeneStartEntry
KFNFVKAYFFLSVAA

CFAP54

2201

Q96N23
NFKLYSDAFKFIVFL

ATP13A5

391

Q4VNC0
PDIFQVSYFAFKFAK

BMP2K

306

Q9NSY1
FAVIAVQLFKGKFFY

CACNA1B

1296

Q00975
FVEGYFHQFFLTKKE

MMP26

31

Q9NRE1
AFTLKVFIFQFVNFY

ANO7

586

Q6IWH7
TAKFKDFYQFTFTFA

DCUN1D2

151

Q6PH85
QEIRKYFSFPVFFFK

DSTYK

266

Q6XUX3
DFTFVEVYRVKKFQF

CERK

446

Q8TCT0
QIVSFYFKLFKNFKD

IFNG

71

P01579
YTVVAFNFFRKFYNK

RYR2

4781

Q92736
FVRKFIVDYFFEEKQ

CPNE5

76

Q9HCH3
FFIAFVIFFQKYSQL

CLEC4A

61

Q9UMR7
TVKRYFAKFEEKFFQ

XPR1

46

Q9UBH6
VVAFNFFRKFYNKSE

RYR3

4686

Q15413
LIDLYQKFGFKVFSF

TEX264

111

Q9Y6I9
FVFDIFQFAKKFVVY

UAP1

381

Q16222