Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	sexual reproduction	CFAP47 UBR2 EFCAB9 RAI14 FXR1 TRIM36 TTK ANAPC7 INTS13 STAG2 DNAH1	1.71e-06	1312	31	11	GO:0019953
GeneOntologyBiologicalProcess	regulation of translation at presynapse, modulating synaptic transmission	FXR1 FXR2	6.55e-06	3	31	2	GO:0099577
GeneOntologyBiologicalProcess	regulation of translation at presynapse	FXR1 FXR2	6.55e-06	3	31	2	GO:0140244
GeneOntologyBiologicalProcess	regulation of translation at synapse, modulating synaptic transmission	FXR1 FXR2	7.82e-05	9	31	2	GO:0099547
GeneOntologyBiologicalProcess	positive regulation of long-term neuronal synaptic plasticity	FXR1 FXR2	1.19e-04	11	31	2	GO:0048170
GeneOntologyBiologicalProcess	flagellated sperm motility	CFAP47 EFCAB9 INTS13 DNAH1	1.67e-04	186	31	4	GO:0030317
GeneOntologyBiologicalProcess	regulation of translation at synapse	FXR1 FXR2	1.69e-04	13	31	2	GO:0140243
GeneOntologyBiologicalProcess	sperm motility	CFAP47 EFCAB9 INTS13 DNAH1	1.92e-04	193	31	4	GO:0097722
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	CFAP47 EFCAB9 INTS13 DNAH1	2.65e-04	210	31	4	GO:0060294
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	CFAP47 EFCAB9 INTS13 DNAH1	2.90e-04	215	31	4	GO:0001539
GeneOntologyBiologicalProcess	cilium-dependent cell motility	CFAP47 EFCAB9 INTS13 DNAH1	2.90e-04	215	31	4	GO:0060285
GeneOntologyBiologicalProcess	spindle organization	TRIM36 TTK INTS13 STAG2	3.38e-04	224	31	4	GO:0007051
GeneOntologyBiologicalProcess	chromosome organization	RFC1 TTK ANAPC7 STAG2 MAP3K4 YLPM1	4.79e-04	686	31	6	GO:0051276
GeneOntologyBiologicalProcess	gamete generation	CFAP47 UBR2 EFCAB9 RAI14 FXR1 TTK DNAH1	5.22e-04	982	31	7	GO:0007276
GeneOntologyBiologicalProcess	cilium movement	CFAP47 EFCAB9 INTS13 DNAH1	6.02e-04	261	31	4	GO:0003341
GeneOntologyBiologicalProcess	spermatid development	CFAP47 EFCAB9 FXR1 DNAH1	6.11e-04	262	31	4	GO:0007286
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	CFAP47 TRIM36 TTK INTS13 STAG2 DNAH1	6.18e-04	720	31	6	GO:0000226
GeneOntologyBiologicalProcess	regulation of chromosome organization	TTK ANAPC7 MAP3K4 YLPM1	6.47e-04	266	31	4	GO:0033044
GeneOntologyBiologicalProcess	spermatid differentiation	CFAP47 EFCAB9 FXR1 DNAH1	7.03e-04	272	31	4	GO:0048515
GeneOntologyBiologicalProcess	spermatogenesis	CFAP47 UBR2 EFCAB9 RAI14 FXR1 DNAH1	7.34e-04	744	31	6	GO:0007283
GeneOntologyBiologicalProcess	microtubule-based process	CFAP47 EFCAB9 TRIM36 TTK INTS13 STAG2 DNAH1	8.14e-04	1058	31	7	GO:0007017
GeneOntologyBiologicalProcess	male gamete generation	CFAP47 UBR2 EFCAB9 RAI14 FXR1 DNAH1	8.32e-04	762	31	6	GO:0048232
GeneOntologyBiologicalProcess	dentate gyrus development	FXR1 FXR2	9.89e-04	31	31	2	GO:0021542
GeneOntologyBiologicalProcess	sperm axoneme assembly	CFAP47 DNAH1	1.19e-03	34	31	2	GO:0007288
GeneOntologyBiologicalProcess	microtubule bundle formation	CFAP47 TRIM36 DNAH1	1.32e-03	145	31	3	GO:0001578
GeneOntologyBiologicalProcess	mitotic spindle organization	TTK INTS13 STAG2	1.49e-03	151	31	3	GO:0007052
GeneOntologyBiologicalProcess	regulation of long-term neuronal synaptic plasticity	FXR1 FXR2	1.65e-03	40	31	2	GO:0048169
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	CFAP47 UBR2 EFCAB9 RAI14 FXR1 TTK DNAH1	1.65e-03	1194	31	7	GO:0048609
Domain	FXR_C1	FXR1 FXR2	2.49e-06	2	30	2	PF16096
Domain	FXR_C1	FXR1 FXR2	2.49e-06	2	30	2	IPR032172
Domain	FXMRP1_C_core	FXR1 FXR2	7.48e-06	3	30	2	IPR022034
Domain	Agenet	FXR1 FXR2	7.48e-06	3	30	2	PF05641
Domain	FXMRP1_C_core	FXR1 FXR2	7.48e-06	3	30	2	PF12235
Domain	Agenet-like_dom	FXR1 FXR2	7.48e-06	3	30	2	IPR008395
Domain	AGENET_LIKE	FXR1 FXR2	7.48e-06	3	30	2	PS51641
Domain	ATPase_dyneun-rel_AAA	VWA8 DNAH1	2.24e-04	14	30	2	IPR011704
Domain	AAA_5	VWA8 DNAH1	2.24e-04	14	30	2	PF07728
Domain	KH_1	FXR1 FXR2	1.69e-03	38	30	2	PF00013
Domain	-	FXR1 FXR2	1.78e-03	39	30	2	3.30.1370.10
Domain	KH	FXR1 FXR2	1.87e-03	40	30	2	SM00322
Domain	KH_dom	FXR1 FXR2	1.87e-03	40	30	2	IPR004087
Domain	KH_TYPE_1	FXR1 FXR2	2.06e-03	42	30	2	PS50084
Domain	KH_dom_type_1	FXR1 FXR2	2.26e-03	44	30	2	IPR004088
Domain	Ser/Thr_kinase_AS	GAK TTK WNK4 MAP3K4	2.43e-03	357	30	4	IPR008271
Domain	S_TKc	GAK TTK WNK4 MAP3K4	2.48e-03	359	30	4	SM00220
Domain	PROTEIN_KINASE_ST	GAK TTK WNK4 MAP3K4	2.55e-03	362	30	4	PS00108
Domain	Pkinase	GAK TTK WNK4 MAP3K4	3.07e-03	381	30	4	PF00069
Domain	VWA	VWA8 VWA5A	3.64e-03	56	30	2	PF00092
Domain	EF_HAND_2	PLCD3 EFCAB9 RYR2	5.93e-03	231	30	3	PS50222
Domain	PROTEIN_KINASE_ATP	GAK TTK WNK4 MAP3K4	5.95e-03	459	30	4	PS00107
Domain	-	ARHGAP5 RFC1 VWA8 YLPM1 DNAH1	6.23e-03	746	30	5	3.40.50.300
Domain	ZF_BBOX	TRIM36 MYCBP2	7.29e-03	80	30	2	PS50119
Domain	Prot_kinase_dom	GAK TTK WNK4 MAP3K4	7.42e-03	489	30	4	IPR000719
Domain	Znf_B-box	TRIM36 MYCBP2	7.47e-03	81	30	2	IPR000315
Domain	PROTEIN_KINASE_DOM	GAK TTK WNK4 MAP3K4	7.63e-03	493	30	4	PS50011
Domain	VWFA	VWA8 VWA5A	7.65e-03	82	30	2	PS50234
Domain	VWA	VWA8 VWA5A	8.01e-03	84	30	2	SM00327
Domain	-	PLCD3 EFCAB9 RYR2	8.29e-03	261	30	3	1.10.238.10
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	FXR1 RFC1 MYCBP2 FXR2 WNK4 RYR2 YLPM1	1.39e-07	462	31	7	31138677
Pubmed	Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2.	FXR1 FXR2	7.69e-07	2	31	2	11735223
Pubmed	Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.	FXR1 FXR2	7.69e-07	2	31	2	21072162
Pubmed	Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.	FXR1 FXR2	7.69e-07	2	31	2	10196376
Pubmed	A protein interaction landscape of breast cancer.	UBR2 RAI14 GAK FXR1 VWA8 FXR2 GARS1	1.16e-06	634	31	7	34591612
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	SART1 TMEM106B RAI14 GAK RFC1 MYCBP2 TTK FXR2 GARS1	1.30e-06	1297	31	9	33545068
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SART1 FXR1 RFC1 MYCBP2 FXR2 STAG2 YLPM1	1.42e-06	653	31	7	22586326
Pubmed	LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.	FXR1 FXR2	2.31e-06	3	31	2	38587486
Pubmed	The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.	FXR1 FXR2	2.31e-06	3	31	2	10888599
Pubmed	Fragile X-related proteins regulate mammalian circadian behavioral rhythms.	FXR1 FXR2	2.31e-06	3	31	2	18589395
Pubmed	FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion.	FXR1 FXR2	2.31e-06	3	31	2	28767039
Pubmed	Spatial control of nucleoporin condensation by fragile X-related proteins.	FXR1 FXR2	2.31e-06	3	31	2	32706158
Pubmed	Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.	FXR1 FXR2	2.31e-06	3	31	2	12417522
Pubmed	The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.	FXR1 FXR2	2.31e-06	3	31	2	7489725
Pubmed	Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.	FXR1 FXR2	2.31e-06	3	31	2	8668200
Pubmed	Evidence that fragile X mental retardation protein is a negative regulator of translation.	FXR1 FXR2	2.31e-06	3	31	2	11157796
Pubmed	Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.	FXR1 FXR2	2.31e-06	3	31	2	27770568
Pubmed	CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.	PLCD3 MAP3K4	2.31e-06	3	31	2	36071682
Pubmed	Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer.	FXR1 FXR2	2.31e-06	3	31	2	32878499
Pubmed	Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.	FXR1 FXR2	2.31e-06	3	31	2	26612855
Pubmed	Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.	FXR1 FXR2	2.31e-06	3	31	2	9259278
Pubmed	Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.	FXR1 FXR2	2.31e-06	3	31	2	19487368
Pubmed	Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.	FXR1 FXR2	2.31e-06	3	31	2	20442204
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	SART1 FXR1 MYCBP2 TTK FXR2 ANAPC7 YLPM1	2.80e-06	724	31	7	36232890
Pubmed	Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.	FXR1 FXR2	4.61e-06	4	31	2	28204491
Pubmed	Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.	FXR1 FXR2	4.61e-06	4	31	2	10567518
Pubmed	The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.	FXR1 FXR2	4.61e-06	4	31	2	16571602
Pubmed	Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.	FXR1 FXR2	4.61e-06	4	31	2	18664458
Pubmed	A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.	FXR1 FXR2	4.61e-06	4	31	2	10556305
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SART1 UBR2 RAI14 FXR1 RFC1 FXR2 GARS1 DNAH1	1.01e-05	1247	31	8	27684187
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SART1 TTK ANAPC7 INTS13 STAG2 YLPM1	1.10e-05	582	31	6	20467437
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	FXR1 FXR2	1.15e-05	6	31	2	11438699
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	SART1 FXR1 RFC1 TTK FXR2 ANAPC7 TMEM70	1.89e-05	971	31	7	33306668
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ARHGAP5 RAI14 FXR1 RFC1 VWA8 FXR2 GARS1 YLPM1	2.00e-05	1371	31	8	36244648
Pubmed	Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.	FXR1 FXR2	2.15e-05	8	31	2	23974796
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SART1 RFC1 FXR2 ANAPC7 STAG2	2.43e-05	394	31	5	27248496
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SART1 FXR1 ANAPC7 STAG2 RYR2 SCN4A GARS1 YLPM1	2.88e-05	1442	31	8	35575683
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	FXR1 MYCBP2 VWA8 STAG2	2.90e-05	199	31	4	31146259
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	GAK MYCBP2 VWA8 YLPM1	3.07e-05	202	31	4	24639526
Pubmed	UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.	FXR1 FXR2	3.44e-05	10	31	2	31114027
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	SART1 RAI14 GAK FXR1 FXR2	3.68e-05	430	31	5	32581705
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	FXR1 MYCBP2 VWA8 TTK FXR2 ANAPC7 TMEM70 GARS1	3.74e-05	1496	31	8	32877691
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	SART1 FXR1 RFC1 FXR2	3.92e-05	215	31	4	30462309
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	FXR1 MYCBP2 FXR2 MAP3K4 YLPM1	4.10e-05	440	31	5	34244565
Pubmed	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.	FXR1 FXR2	4.21e-05	11	31	2	29142209
Pubmed	Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.	FXR1 FXR2	4.21e-05	11	31	2	22022532
Pubmed	FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124.	FXR1 FXR2	4.21e-05	11	31	2	21957233
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	RAI14 FXR1 RFC1 MYCBP2 FXR2 ANAPC7 GARS1	5.53e-05	1149	31	7	35446349
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	SART1 RAI14 TTK ANAPC7 STAG2 GARS1 YLPM1	5.72e-05	1155	31	7	20360068
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	ANAPC7 STAG2	6.95e-05	14	31	2	11076961
Pubmed	Transcription profile during maternal to zygotic transition in the mouse embryo.	FXR1 GARS1	6.95e-05	14	31	2	16930510
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	SART1 ARHGAP5 RAI14 FXR1 RFC1 FXR2	8.97e-05	847	31	6	35850772
Pubmed	Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.	ANAPC7 STAG2	1.04e-04	17	31	2	21043528
Pubmed	Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.	SART1 RFC1 INTS13	1.04e-04	102	31	3	26584622
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	FXR1 RFC1 VWA8 ANAPC7 INTS13	1.28e-04	560	31	5	35241646
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	SART1 FXR1 FXR2	1.44e-04	114	31	3	31553912
Pubmed	QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.	RAI14 RYR2	1.45e-04	20	31	2	33397958
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PLCD3 SART1 RAI14 FXR1 RFC1 MYCBP2 GARS1	1.54e-04	1353	31	7	29467282
Pubmed	The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation.	FXR1 FXR2	1.60e-04	21	31	2	37059803
Pubmed	Functional proteomics mapping of a human signaling pathway.	PLCD3 ARHGAP5 MYCBP2 RYR2 YLPM1	1.64e-04	591	31	5	15231748
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	SART1 FXR1 RFC1 FXR2	1.73e-04	316	31	4	31665637
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	GAK MYCBP2 VWA8 TTK FXR2	1.84e-04	606	31	5	36538041
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SART1 FXR1 RFC1 VWA8 FXR2 STAG2 GARS1	2.02e-04	1415	31	7	28515276
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	SART1 RFC1 ANAPC7	2.08e-04	129	31	3	23022380
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SART1 MYCBP2 VWA8 FXR2 ANAPC7 YLPM1	2.27e-04	1005	31	6	19615732
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	RFC1 FXR2 INTS13 STAG2 RYR2	2.34e-04	638	31	5	31182584
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	SART1 RFC1 ANAPC7 INTS13 STAG2 YLPM1	2.39e-04	1014	31	6	32416067
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SART1 FXR1 MYCBP2 ANAPC7 STAG2 YLPM1	2.52e-04	1024	31	6	24711643
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SART1 FXR1 RFC1 FXR2 YLPM1	2.64e-04	655	31	5	35819319
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	FXR1 FXR2	2.66e-04	27	31	2	29420262
Pubmed	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.	RAI14 ANAPC7	2.66e-04	27	31	2	18685082
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	INTS13 STAG2 RYR2	2.75e-04	142	31	3	11812828
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	UBR2 ARHGAP5 RAI14 TRIM36 MYCBP2 YLPM1	2.86e-04	1049	31	6	27880917
Pubmed	TERRA transcripts are bound by a complex array of RNA-binding proteins.	FXR1 FXR2	2.86e-04	28	31	2	20975687
Pubmed	Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.	TMEM106B RYR2	2.86e-04	28	31	2	23006423
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	FXR1 FXR2 GARS1 YLPM1	2.97e-04	364	31	4	24778252
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	FXR1 FXR2 YLPM1	3.05e-04	147	31	3	28977470
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SART1 RFC1 MYCBP2 ANAPC7 STAG2 GARS1	3.74e-04	1103	31	6	34189442
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SART1 RAI14 FXR1 RFC1 FXR2	3.90e-04	713	31	5	29802200
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SART1 FXR1 VWA8 FXR2 ANAPC7 INTS13	3.98e-04	1116	31	6	31753913
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	FXR1 FXR2 YLPM1	4.05e-04	162	31	3	31363146
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	GAK FXR1 MYCBP2 FXR2 YLPM1	4.42e-04	733	31	5	34672954
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	ARHGAP5 RAI14 ANAPC7	4.43e-04	167	31	3	25659891
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	FXR2 ANAPC7 INTS13 YLPM1	4.70e-04	411	31	4	35182466
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	FXR1 MYCBP2 VWA8 FXR2 GARS1	5.03e-04	754	31	5	33060197
Pubmed	Defining the membrane proteome of NK cells.	GAK FXR1 MYCBP2 TTK FXR2 STAG2	5.07e-04	1168	31	6	19946888
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	MYCBP2 ANAPC7 GARS1	5.07e-04	175	31	3	25756610
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	SART1 FXR1 RFC1 MYCBP2 FXR2	5.18e-04	759	31	5	35915203
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	FXR1 FXR2	5.30e-04	38	31	2	30629181
Pubmed	Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.	SART1 FXR2	5.30e-04	38	31	2	23537643
Pubmed	Large-scale identification of mammalian proteins localized to nuclear sub-compartments.	RFC1 YLPM1	5.30e-04	38	31	2	11555636
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SART1 RFC1 MYCBP2 STAG2 YLPM1	5.67e-04	774	31	5	15302935
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	SART1 FXR1 RFC1 FXR2	6.12e-04	441	31	4	31239290
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	RAI14 RFC1 MYCBP2	6.44e-04	190	31	3	15161933
Pubmed	Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.	GAK MYCBP2	7.11e-04	44	31	2	22645275
Pubmed	A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.	FXR1 FXR2	7.43e-04	45	31	2	25496916
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	FXR1 RFC1 MYCBP2 ANAPC7 TMEM70 GARS1	7.46e-04	1257	31	6	37317656
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SART1 RAI14 FXR1 RFC1 FXR2 GARS1	7.46e-04	1257	31	6	36526897
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	FXR1 VWA8 FXR2	7.81e-04	203	31	3	35012549
Pubmed	Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.	VWA5A WNK4	8.11e-04	47	31	2	15172686
Interaction	PHC1P1 interactions	FXR1 FXR2	1.20e-05	4	29	2	int:PHC1P1
Interaction	TNIK interactions	PLCD3 SART1 FXR1 MYCBP2 FXR2 INTS13	1.44e-05	381	29	6	int:TNIK
Interaction	KIF2A interactions	FXR1 TRIM36 MYCBP2 TTK FXR2	2.25e-05	242	29	5	int:KIF2A
Interaction	IMPDH2 interactions	GAK FXR1 TTK FXR2 INTS13 JMY	2.50e-05	420	29	6	int:IMPDH2
Interaction	SLAIN2 interactions	FXR1 TRIM36 MYCBP2 FXR2	2.97e-05	125	29	4	int:SLAIN2
Interaction	LGR4 interactions	TMEM106B GAK MYCBP2 VWA8 YLPM1	3.29e-05	262	29	5	int:LGR4
Interaction	ICAM4 interactions	TMEM106B MYCBP2 SCN4A	3.90e-05	46	29	3	int:ICAM4
Interaction	PARP16 interactions	RAI14 VWA8 SCN4A	5.02e-05	50	29	3	int:PARP16
Interaction	KIF7 interactions	FXR1 TRIM36 FXR2 MAP3K4	5.45e-05	146	29	4	int:KIF7
Interaction	UQCR11 interactions	RAI14 INTS13 YLPM1	5.98e-05	53	29	3	int:UQCR11
Interaction	SIRT7 interactions	SART1 FXR1 RFC1 MYCBP2 FXR2 STAG2 YLPM1	6.97e-05	744	29	7	int:SIRT7
Interaction	PLK1 interactions	ARHGAP5 RAI14 TRIM36 MYCBP2 ANAPC7 STAG2	7.38e-05	510	29	6	int:PLK1
Interaction	AXIN1 interactions	GAK FXR1 FXR2 MAP3K4	8.98e-05	166	29	4	int:AXIN1
Interaction	ZBTB3 interactions	FXR1 VWA8 FXR2	1.05e-04	64	29	3	int:ZBTB3
Interaction	EED interactions	SART1 RAI14 GAK FXR1 MYCBP2 FXR2 STAG2 GARS1 YLPM1	1.31e-04	1445	29	9	int:EED
Interaction	HDLBP interactions	RAI14 FXR1 RFC1 TTK FXR2 GARS1 YLPM1	1.66e-04	855	29	7	int:HDLBP
Interaction	EGFL7 interactions	TMEM106B FXR1 FXR2	1.82e-04	77	29	3	int:EGFL7
Interaction	PYCR2 interactions	FXR1 VWA8 FXR2 TMEM70	2.18e-04	209	29	4	int:PYCR2
Interaction	SIRT6 interactions	FXR1 MYCBP2 FXR2 ANAPC7 MAP3K4 YLPM1	2.30e-04	628	29	6	int:SIRT6
Interaction	CAPRIN2 interactions	FXR1 FXR2	2.37e-04	16	29	2	int:CAPRIN2
Interaction	TRMT10C interactions	VWA8 ANAPC7 VWA5A TMEM70	2.43e-04	215	29	4	int:TRMT10C
GeneFamily	EF-hand domain containing	EFCAB9 RYR2	2.18e-02	219	19	2	863
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	ARHGAP5 RAI14 FXR1 RFC1 MYCBP2 TTK STAG2	9.28e-06	656	31	7	M18979
Disease	malignant pleural mesothelioma (implicated_via_orthology)	FXR1 FXR2	3.00e-06	3	30	2	DOID:7474 (implicated_via_orthology)
Disease	fragile X syndrome (implicated_via_orthology)	FXR1 FXR2	3.00e-06	3	30	2	DOID:14261 (implicated_via_orthology)
Disease	eating disorder, bipolar disorder	FXR1 RYR2	9.02e-05	14	30	2	EFO_0005203, MONDO_0004985
Disease	Mitochondrial disease	TMEM70 SCN4A	1.14e-03	49	30	2	cv:C0751651
Disease	generalised epilepsy	TRIM36 RYR2	1.28e-03	52	30	2	EFO_0005917

Protein segments in the cluster

Peptide	Gene	Start	Entry
YEEMKSSYCSVIENM	RAI14	576	Q9P0K7
VESSMEYCRIMYDIF	INTS13	56	Q9NVM9
EIEVKYKMAECYTML	ANAPC7	101	Q9UJX3
VYYDTYESMEAMLEK	JMY	571	Q8N9B5
MMKGDFYVIEYAACD	FXR2	96	P51116
MMKGEFYVIEYAACD	FXR1	86	P51114
LCIKENYFGEDDMYM	KIAA1109	746	Q2LD37
VGEIDFEKFYMLVCM	EFCAB9	76	A8MZ26
TKDMFIMEIDAICYY	NPHS2	181	Q9NP85
ECYESEMLVAYCMFQ	DEFB134	41	Q4QY38
SHKRYIEYMCDMVAE	GAK	551	O14976
VKVMDDYQVMDEFLY	DNAH1	886	Q9P2D7
KLEEDFLYMAYADIM	RYR2	3681	Q92736
CVALYMIEKSYDIMA	CFAP47	2976	Q6ZTR5
HREEMYIFMEYCDEG	MAP3K4	1411	Q9Y6R4
TVIAEEMSYMYDFCT	TMEM106B	201	Q9NUM4
KVDFYDMDQMKCLYE	TRIM36	676	Q9NQ86
EYADKVFTYIFIMEM	SCN4A	1066	P35499
VVALMDTYYLMKEDF	RFC1	1021	P35251
DTYYLMKEDFENIME	RFC1	1026	P35251
MEYLAICDECYITEM	GARS1	516	P41250
AYDCAAREKYAMMFD	MYCBP2	1306	O75592
EEVMCFVMEDEAYKY	ARHGAP5	451	Q13017
CQYSIIYDEYMMDTV	STAG2	186	Q8N3U4
VDMNDMYAYLLFKEC	PLCD3	216	Q8N3E9
ELMCYKAKTFQMDDY	VWA5A	646	O00534
AVYCIEDKMAIDDKY	SART1	671	O43290
VMEYEYEAEMEETYR	YLPM1	1896	P49750
YEITDQYIYMVMECG	TTK	591	P33981
MGYDKEEFILYMEET	TMEM70	236	Q9BUB7
AVCMVMEAFENYEEK	VWA8	1741	A3KMH1
ADLEMVEKSDTYYCM	UBR2	216	Q8IWV8
KYDEAVDVYAFGMCM	WNK4	351	Q96J92