Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coregulator activity

HDAC3 NRG1 TLE2 EID1 SMARCA2 JAZF1 PQBP1 JMY TRIM52

2.03e-04562739GO:0003712
GeneOntologyMolecularFunctionpre-mRNA 3'-splice site binding

ZRSR2P1 ZRSR2

2.74e-047732GO:0030628
GeneOntologyMolecularFunctionhistone binding

ZZZ3 BRD2 SMARCA2 SSRP1 ATAD2 CTSL

4.18e-04265736GO:0042393
GeneOntologyBiologicalProcessprotein-containing complex disassembly

NRG1 IGF1R MAP1B APC SSRP1 ATAD2 SMCR8 RUBCN

8.66e-06291738GO:0032984
GeneOntologyBiologicalProcessneuron projection regeneration

NRG1 IGF1R MAP1B CSPG5 MAP4K4

1.00e-0581735GO:0031102
GeneOntologyBiologicalProcesscellular component disassembly

NRG1 HBS1L IGF1R GBF1 MAP1B APC SSRP1 ATAD2 SMCR8 MAP4K4 RUBCN

1.04e-056177311GO:0022411
GeneOntologyBiologicalProcesspositive regulation of cold-induced thermogenesis

HDAC3 IGF1R APC GNAS CNOT3

3.08e-05102735GO:0120162
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription, elongation

ERCC6 EAPP LEO1 SUPT5H

6.90e-0562734GO:0032786
GeneOntologyBiologicalProcessregulation of cardiac muscle cell differentiation

SOX6 HDAC3 NRG1

9.25e-0525733GO:2000725
GeneOntologyBiologicalProcessaxon regeneration

NRG1 IGF1R MAP1B CSPG5

1.05e-0469734GO:0031103
GeneOntologyBiologicalProcessregulation of protein-containing complex disassembly

IGF1R MAP1B APC SMCR8 RUBCN

1.59e-04144735GO:0043244
GeneOntologyBiologicalProcessregulation of cold-induced thermogenesis

HDAC3 IGF1R APC GNAS CNOT3

2.04e-04152735GO:0120161
GeneOntologyBiologicalProcesscold-induced thermogenesis

HDAC3 IGF1R APC GNAS CNOT3

2.30e-04156735GO:0106106
GeneOntologyCellularComponenttranscription elongation factor complex

ERCC6 LEO1 SUPT5H SSRP1

3.93e-0556714GO:0008023
GeneOntologyCellularComponentU2AF complex

ZRSR2P1 ZRSR2

2.36e-047712GO:0089701
GeneOntologyCellularComponentintracellular protein-containing complex

ZZZ3 LEO1 CCDC47 POLR2C NFKBIA ARIH2 APC MCM3 REV3L SMCR8 CNOT3

4.11e-049727111GO:0140535
HumanPhenoAbnormal hand morphology

SOX6 NPHP1 COL7A1 C2CD3 BRIP1 IGF1R ERCC6 TXNDC15 MAP1B KIF1A CCDC47 SMARCA2 APC CEP152 GNAS REV3L PQBP1 CNOT3

1.85e-0710822618HP:0005922
HumanPhenoAbnormal 5th finger morphology

SOX6 NPHP1 C2CD3 BRIP1 TXNDC15 MAP1B CCDC47 SMARCA2 CEP152 GNAS REV3L PQBP1 CNOT3

2.61e-075092613HP:0004207
HumanPhenoAbnormal finger morphology

SOX6 NPHP1 BMP1 COL7A1 C2CD3 BRIP1 IGF1R ERCC6 TXNDC15 MAP1B KIF1A CCDC47 SMARCA2 APC CEP152 GNAS REV3L PQBP1 CNOT3

1.37e-0613852619HP:0001167
HumanPhenoAbnormal toe morphology

SOX6 BMP1 C2CD3 BRIP1 IGF1R GBF1 ERCC6 TXNDC15 KIF1A CCDC47 SMARCA2 APC CEP152 GNAS PQBP1

4.58e-068932615HP:0001780
HumanPhenoRadial deviation of finger

SOX6 NPHP1 BRIP1 IGF1R MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

4.92e-064482611HP:0009466
HumanPhenoRadial deviation of the hand or of fingers of the hand

SOX6 NPHP1 BRIP1 IGF1R MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

5.86e-064562611HP:0009485
HumanPhenoAbnormal calvaria morphology

SOX6 NPHP1 BMP1 C2CD3 BRIP1 ERCC6 TXNDC15 MAP1B KIF1A CCDC47 NFKBIA SMARCA2 APC CEP152 GNAS PQBP1 CNOT3

1.24e-0512542617HP:0002683
HumanPhenoClinodactyly of the 5th finger

SOX6 NPHP1 BRIP1 MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

2.08e-054202610HP:0004209
HumanPhenoClinodactyly of hands

SOX6 NPHP1 BRIP1 MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

2.12e-054212610HP:0001157
HumanPhenoDeviation of the 5th finger

SOX6 NPHP1 BRIP1 MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

2.12e-054212610HP:0009179
HumanPhenoAbnormal hair quantity

SOX6 NPHP1 BMP1 COL7A1 IGF1R ERCC6 MAP1B CCDC47 NFKBIA SMARCA2 JAZF1 CEP152 GNAS PQBP1

2.62e-058882614HP:0011362
HumanPhenoDeviation of finger

SOX6 NPHP1 BRIP1 IGF1R MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

2.84e-055372611HP:0004097
HumanPhenoFinger clinodactyly

SOX6 NPHP1 BRIP1 MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

3.95e-054522610HP:0040019
HumanPhenoAbnormal hair pattern

SOX6 NPHP1 BMP1 IGF1R ERCC6 MAP1B CCDC47 SMARCA2 APC GNAS PQBP1 CNOT3

4.41e-056762612HP:0010720
HumanPhenoDeviation of the hand or of fingers of the hand

SOX6 NPHP1 BRIP1 IGF1R MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

4.52e-055642611HP:0009484
HumanPhenoClinodactyly

SOX6 NPHP1 BRIP1 IGF1R MAP1B CCDC47 SMARCA2 CEP152 REV3L PQBP1 CNOT3

5.34e-055742611HP:0030084
HumanPhenoAbnormal hair morphology

SOX6 NPHP1 BMP1 COL7A1 BRIP1 IGF1R ERCC6 MAP1B CCDC47 NFKBIA SMARCA2 APC JAZF1 CEP152 GNAS PQBP1 CNOT3

7.48e-0514242617HP:0001595
HumanPhenoAbnormality of the palpebral fissures

SOX6 NPHP1 BMP1 C2CD3 BRIP1 IGF1R ERCC6 CCDC47 SMARCA2 APC CEP152 PQBP1 CNOT3

1.27e-048802613HP:0008050
HumanPhenoDry hair

ERCC6 SMARCA2 PQBP1

1.27e-0420263HP:0011359
HumanPhenoIrregular hyperpigmentation

COL7A1 BRIP1 ERCC6 SMARCA2 APC GNAS REV3L

1.36e-04238267HP:0007400
HumanPhenoAbnormal odontoid tissue morphology

BMP1 COL7A1 ERCC6 SMARCA2 APC CEP152 GNAS

1.36e-04238267HP:3000050
HumanPhenoAbnormality of the dentition

NPHP1 BMP1 COL7A1 C2CD3 ERCC6 CCDC47 SH3BP2 NFKBIA SMARCA2 APC CEP152 GNAS REV3L PQBP1

1.46e-0410302614HP:0000164
HumanPhenoEnamel hypoplasia

COL7A1 ERCC6 SMARCA2 CEP152 GNAS

1.51e-04104265HP:0006297
HumanPhenoTriangular face

SOX6 BMP1 IGF1R ERCC6 SMARCA2 PQBP1

1.51e-04167266HP:0000325
HumanPhenoAbnormality of the outer ear

SOX6 NPHP1 BMP1 COL7A1 C2CD3 BRIP1 IGF1R ERCC6 TXNDC15 MAP1B CCDC47 SMARCA2 APC CEP152 PQBP1 CNOT3

1.54e-0413372616HP:0000356
HumanPhenoHypertrichosis

SOX6 NPHP1 BMP1 IGF1R ERCC6 MAP1B CCDC47 SMARCA2 GNAS

1.55e-04425269HP:0000998
HumanPhenoAbnormal breast morphology

SOX6 BRIP1 IGF1R ERCC6 CCDC47 SMARCA2 APC GNAS REV3L

2.06e-04441269HP:0031093
HumanPhenoAbnormal facial shape

SOX6 NPHP1 BMP1 C2CD3 BRIP1 IGF1R ERCC6 CCDC47 SH3BP2 SMARCA2 APC CEP152 GNAS PQBP1 CNOT3

2.28e-0412212615HP:0001999
HumanPhenoAbnormality of the breast

SOX6 BRIP1 IGF1R ERCC6 CCDC47 SMARCA2 APC GNAS REV3L

2.29e-04447269HP:0000769
HumanPhenoAbnormal eyelid morphology

SOX6 NPHP1 BMP1 C2CD3 BRIP1 IGF1R ERCC6 MAP1B CCDC47 SH3BP2 SMARCA2 APC CEP152 REV3L PQBP1 CNOT3

2.98e-0414082616HP:0000492
HumanPhenoAbnormal long bone morphology

NPHP1 BMP1 BRIP1 ERCC6 TXNDC15 KIF1A CCDC47 SMARCA2 APC CEP152 GNAS REV3L

3.04e-048212612HP:0011314
HumanPhenoHypoplasia of teeth

COL7A1 ERCC6 SMARCA2 CEP152 GNAS

3.71e-04126265HP:0000685
HumanPhenoHypermelanotic macule

BRIP1 ERCC6 SMARCA2 APC GNAS REV3L

4.16e-04201266HP:0001034
HumanPhenoAbnormality of hair texture

IGF1R ERCC6 CCDC47 NFKBIA SMARCA2 CEP152 PQBP1

4.64e-04290267HP:0010719
HumanPhenoAbnormal pinna morphology

SOX6 NPHP1 BMP1 C2CD3 BRIP1 IGF1R ERCC6 TXNDC15 MAP1B CCDC47 SMARCA2 APC CEP152 PQBP1 CNOT3

4.75e-0412992615HP:0000377
HumanPhenoCafe-au-lait spot

BRIP1 SMARCA2 APC GNAS REV3L

5.46e-04137265HP:0000957
HumanPhenoAbnormal dental morphology

NPHP1 CCDC47 SH3BP2 NFKBIA SMARCA2 REV3L PQBP1

5.59e-04299267HP:0006482
HumanPhenoAbnormal bone structure

NPHP1 BMP1 COL7A1 BRIP1 ERCC6 TXNDC15 KIF1A SH3BP2 NFKBIA APC CEP152 GNAS

5.97e-048812612HP:0003330
HumanPhenoHirsutism

SOX6 NPHP1 BMP1 ERCC6 MAP1B GNAS

6.12e-04216266HP:0001007
HumanPhenoLong fingers

SOX6 BMP1 MAP1B KIF1A SMARCA2 PQBP1 CNOT3

6.42e-04306267HP:0100807
HumanPhenoAbnormal dental enamel morphology

COL7A1 ERCC6 SMARCA2 APC CEP152 GNAS

6.91e-04221266HP:0000682
HumanPhenoAplasia/hypoplasia involving the skeleton

SOX6 C2CD3 BRIP1 IGF1R ERCC6 TXNDC15 KIF1A CCDC47 SMARCA2 APC CEP152 GNAS REV3L PQBP1 CNOT3

6.99e-0413432615HP:0009115
HumanPhenoSparse or absent hair

COL7A1 IGF1R ERCC6 NFKBIA SMARCA2 JAZF1 CEP152 GNAS PQBP1

7.66e-04525269HP:0002115
HumanPhenoAbnormal palate morphology

SOX6 NPHP1 C2CD3 BRIP1 IGF1R TXNDC15 MAP1B CCDC47 SH3BP2 SMARCA2 APC CEP152 REV3L PQBP1

8.05e-0412022614HP:0000174
HumanPhenoAbnormal number of teeth

NPHP1 C2CD3 ERCC6 SH3BP2 NFKBIA APC CEP152 REV3L

8.39e-04421268HP:0006483
HumanPhenoAbnormal hip bone morphology

BMP1 BRIP1 ERCC6 KIF1A CCDC47 SMARCA2 APC CEP152 GNAS CNOT3

8.62e-046532610HP:0003272
HumanPhenoAnhidrosis

ERCC6 KIF1A NFKBIA

8.85e-0438263HP:0000970
HumanPhenoMacule

BRIP1 ERCC6 SMARCA2 APC GNAS REV3L

9.34e-04234266HP:0012733
HumanPhenoHyperpigmentation of the skin

COL7A1 BRIP1 ERCC6 SMARCA2 APC GNAS REV3L

9.74e-04328267HP:0000953
HumanPhenoHigh palate

SOX6 NPHP1 BRIP1 IGF1R MAP1B CCDC47 SMARCA2 APC CEP152 REV3L PQBP1

9.98e-047942611HP:0000218
DomaintRNA-bd_arm

SOX6 CEP152 CNOT3

1.05e-0424723IPR010978
DomainU2AF_small

ZRSR2P1 ZRSR2

1.45e-045722IPR009145
DomainBROMODOMAIN_1

BRD2 SMARCA2 ATAD2

3.88e-0437723PS00633
DomainBromodomain

BRD2 SMARCA2 ATAD2

4.21e-0438723PF00439
DomainBROMODOMAIN_2

BRD2 SMARCA2 ATAD2

5.27e-0441723PS50014
DomainBROMO

BRD2 SMARCA2 ATAD2

5.66e-0442723SM00297
DomainBromodomain

BRD2 SMARCA2 ATAD2

5.66e-0442723IPR001487
Domain-

BRD2 SMARCA2 ATAD2

5.66e-04427231.20.920.10
DomainPentatricopeptide_repeat

GNAS DENND4C

3.52e-0323722IPR002885
DomainBromodomain_CS

BRD2 SMARCA2

4.49e-0326722IPR018359
DomainP-loop_NTPase

HBS1L BRIP1 ERCC6 KIF1A TJP1 SMARCA2 MCM3 GNAS ATAD2

5.15e-03848729IPR027417
DomainSNF2_N

ERCC6 SMARCA2

6.75e-0332722IPR000330
DomainSNF2_N

ERCC6 SMARCA2

6.75e-0332722PF00176
PathwayREACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX

LEO1 SUPT5H POLR2C SSRP1

7.52e-0558554M805
PathwayREACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX

LEO1 SUPT5H POLR2C SSRP1

8.05e-0559554MM14504
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

HDAC3 SUPT5H NFKBIA

2.57e-0432553M39521
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

SOX6 TLE2 APC

2.57e-0432553MM14975
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

LEO1 SUPT5H POLR2C SSRP1

2.76e-0481554M865
PathwayREACTOME_HIV_ELONGATION_ARREST_AND_RECOVERY

SUPT5H POLR2C SSRP1

2.82e-0433553M27010
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

LEO1 SUPT5H POLR2C SSRP1

3.03e-0483554MM15314
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SOX6 TXNDC15 BRD2 LEO1 KIF1A ZRSR2 TJP1 SUPT5H RALBP1 POLR2C ARIH2 APC CCDC15 REV3L MAP4K4 CTSL CNOT3 TRIM52

1.17e-101285731835914814
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

HDAC3 USP5 EAPP BRD2 LEO1 SUDS3 SUPT5H POLR2C ARIH2 CFDP1 SMARCA2 MCM3 SSRP1 PQBP1 HNRNPLL

2.53e-091014731532416067
Pubmed

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.

IGF1R ERCC6 BRD2 LEO1 SUPT5H POLR2C

2.86e-095973634108663
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

HDAC3 HBS1L LEO1 TJP1 PRCC SH3BP2 POLR2C NFKBIA EID1 GNAS SSRP1 MAP4K4 CNOT3 DENND4C

2.93e-081038731426673895
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

SOX6 HDAC3 BRIP1 ZZZ3 SUPT5H TLE2 POLR2C NFKBIA APC MCM3 PQBP1 CNOT3

2.75e-07877731220211142
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

LEO1 PRCC SUDS3 SUPT5H MCM3 SSRP1

1.27e-0616373622113938
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

C2CD3 IGF1R GBF1 MAP1B TJP1 APC CEP152 GNAS SSRP1 MAP4K4 DENND4C

1.77e-06861731136931259
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

SOX6 HDAC3 LEO1 SUPT5H POLR2C SMARCA2 CNOT3

2.21e-0628273723667531
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

HDAC3 HBS1L ERCC6 BRD2 KIF1A CCDC47 POLR2C SMARCA2 APC SSRP1 ATAD2 PQBP1 HNRNPLL CNOT3

2.41e-061497731431527615
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ZZZ3 LEO1 SUPT5H POLR2C APC MCM3 GNAS PQBP1 CNOT3

3.94e-0658873938580884
Pubmed

ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.

ZRSR2P1 ZRSR2

4.35e-06273233691379
Pubmed

LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage.

ERCC6 LEO1

4.35e-06273234096589
Pubmed

Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.

BMP1 COL7A1

4.35e-06273211986329
Pubmed

Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.

ZRSR2P1 ZRSR2

4.35e-06273235198906
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

BRIP1 GBF1 BRD2 LEO1 SMARCA2 MCM3 SSRP1 ATAD2 MAP4K4 CNOT3

4.94e-06774731015302935
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

USP5 IGF1R BRD2 TJP1 ARIH2 CEP152 ZNF428 GNAS PQBP1 RUBCN JMY DENND4C

8.05e-061215731215146197
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

RPF1 HBS1L LEO1 PRCC SUDS3 SUPT5H CFDP1 MCM3 SSRP1

9.14e-0665373933742100
Pubmed

Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.

ZRSR2P1 ZRSR2

1.30e-0537328586425
Pubmed

Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia.

APC CTSL

1.30e-05373217622569
Pubmed

Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function.

HDAC3 NFKBIA

1.30e-05373216371367
Pubmed

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

IGF1R APC

1.30e-05373226364612
Pubmed

Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.

ZRSR2P1 ZRSR2

1.30e-05373236030305
Pubmed

ZO-1 expression shows prognostic value in chronic B cell leukemia.

TJP1 ZAP70

1.30e-05373226306999
Pubmed

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

BRD2 ATAD2

1.30e-05373228591577
Pubmed

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.

HDAC3 IGF1R APC GNAS CNOT3

1.45e-0514673529688375
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

SOX6 BMP1 NRG1 IGF1R CSPG5 JAZF1

1.51e-0525173629031500
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

BRD2 MAP1B ZRSR2 TJP1 SUPT5H POLR2C APC MCM3 SSRP1 MAP4K4 HNRNPLL

1.53e-051082731138697112
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

HBS1L BRD2 SUPT5H SMARCA2 APC JAZF1 SMCR8

2.08e-0539873735016035
Pubmed

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.

SUPT5H MCM3 SSRP1

2.23e-052673334162889
Pubmed

Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.

LEO1 SUPT5H SSRP1

2.23e-052673333298525
Pubmed

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation.

NFKBIA APC

2.60e-05473227458801
Pubmed

Mouse U2af1-rs1 is a neomorphic imprinted gene.

ZRSR2P1 ZRSR2

2.60e-0547329001233
Pubmed

Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles.

IGF1R APC

2.60e-05473212595570
Pubmed

Duration of nuclear NF-kappaB action regulated by reversible acetylation.

HDAC3 NFKBIA

2.60e-05473211533489
Pubmed

Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex.

NRG1 SMARCA2

2.60e-05473219781646
Pubmed

Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.

HDAC3 APC

2.60e-05473221251616
Pubmed

Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.

ZRSR2P1 ZRSR2

2.60e-0547327558001
Pubmed

mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition.

NRG1 IGF1R

2.60e-05473233273014
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

RPF1 IGF1R GBF1 ZZZ3 KIF1A SUPT5H SSRP1

2.92e-0542073728065597
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

USP5 BRIP1 MCM3 REV3L

3.48e-058773417148452
Pubmed

Network organization of the human autophagy system.

GBF1 MAP1B TJP1 CCDC47 SSRP1 SMCR8 RUBCN

3.76e-0543773720562859
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

HBS1L SUPT5H POLR2C SMARCA2 APC MCM3 SSRP1

3.93e-0544073734244565
Pubmed

Human transcription factor protein interaction networks.

SOX6 HDAC3 CHCHD4 ZZZ3 BRD2 PRCC SUDS3 NFKBIA CFDP1 SMARCA2 CEP152 CNOT3

3.99e-051429731235140242
Pubmed

The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members.

TJP1 APC

4.33e-05573218502210
Pubmed

Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.

HDAC3 NFKBIA

4.33e-05573212972430
Pubmed

FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

SUPT5H SSRP1

4.33e-05573210912001
Pubmed

The RNA polymerase II elongation complex.

SUPT5H POLR2C SSRP1

4.63e-053373312676794
Pubmed

alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.

BRIP1 ERCC6 SMARCA2

5.07e-053473316889989
Pubmed

Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.

IGF1R NFKBIA

6.48e-05673220153290
Pubmed

Acetylation of Stat1 modulates NF-kappaB activity.

HDAC3 NFKBIA

6.48e-05673216481475
Pubmed

FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.

HDAC3 BRIP1

6.48e-05673222792074
Pubmed

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.

APC GNAS

6.48e-05673220531296
Pubmed

Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.

LEO1 POLR2C

6.48e-05673218469135
Pubmed

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.

ZRSR2P1 ZRSR2

6.48e-05673233846634
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

HBS1L LEO1 MAP1B PRCC SUPT5H APC MAP4K4 RUBCN

6.59e-0565073838777146
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PPP2R3A C2CD3 BRD2 LEO1 TJP1 CCDC47 SUPT5H CSPG5 POLR2C PQBP1

6.63e-051049731027880917
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

HDAC3 HBS1L PPP2R3A C2CD3 TJP1 APC MCM3 CEP152 MAP4K4

7.35e-0585373928718761
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

BRD2 LEO1 SUPT5H MCM3 GNAS MAP4K4 HNRNPLL CNOT3

7.72e-0566573830457570
Pubmed

MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.

SOX6 MAP4K4

9.06e-05773238383842
Pubmed

Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.

HDAC3 IGF1R

9.06e-05773229523594
Pubmed

A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.

ZRSR2P1 ZRSR2

9.06e-0577329237760
Pubmed

Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.

NFKBIA APC

9.06e-05773227053111
Pubmed

Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65.

HDAC3 NFKBIA

9.06e-05773212419806
Pubmed

Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation.

LEO1 SSRP1

9.06e-05773222252316
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

HBS1L MAP1B TJP1 APC ATAD2

9.20e-0521573535973513
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

BRIP1 ERCC6 BRD2 SUPT5H REV3L

1.07e-0422273537071664
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZZZ3 ERCC6 BRD2 SUDS3 SH3BP2 POLR2C SMARCA2 JAZF1 REV3L SSRP1

1.10e-041116731031753913
Pubmed

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

GBF1 MAP1B TJP1 NFKBIA APC

1.16e-0422673525900982
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

HBS1L MAP1B CCDC47 APC MCM3 SMCR8 MAP4K4 DENND4C

1.19e-0470873839231216
Pubmed

Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.

ZRSR2P1 ZRSR2

1.21e-04873232371981
Pubmed

Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2.

SH3BP2 ZAP70

1.21e-04873211390470
Pubmed

Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.

SH3BP2 ZAP70

1.21e-0487329846481
Pubmed

The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.

LEO1 CSPG5

1.21e-04873223791194
Pubmed

Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.

SOX6 APC

1.21e-04873226345464
Pubmed

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.

ZRSR2P1 ZRSR2 SPAG16

1.35e-044773329617656
Pubmed

The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.

POLR2C SSRP1

1.55e-04973230508113
Pubmed

SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.

TJP1 APC

1.55e-04973219170756
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

HBS1L ZZZ3 MAP1B TJP1 MCM3 SSRP1 MAP4K4

1.56e-0454973738280479
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

BRIP1 ZZZ3 BRD2 MAP1B TJP1 PRCC MCM3 SSRP1 PQBP1

1.71e-0495473936373674
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

HBS1L GBF1 KIF1A CCDC47 SUPT5H MCM3 GNAS SSRP1 ATAD2 MAP4K4 HNRNPLL

1.81e-041425731130948266
Pubmed

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.

SOX6 NRG1

1.93e-041073215096597
Pubmed

Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling.

MAP1B KIF1A

1.93e-041073224656932
Pubmed

A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.

MCM3 SSRP1

1.93e-041073221055985
Pubmed

Mechanism of glycyrrhizic acid inhibition of Kaposi's sarcoma-associated herpesvirus: disruption of CTCF-cohesin-mediated RNA polymerase II pausing and sister chromatid cohesion.

SUPT5H MCM3

1.93e-041073221880767
Pubmed

Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.

MCM3 SSRP1

1.93e-041073216902406
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

HBS1L MAP1B CCDC47 POLR2C GNAS SSRP1 CNOT3

1.98e-0457173737167062
Pubmed

Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.

RTL5 POLR2C NFKBIA GNAS

2.03e-0413773430862715
Pubmed

De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.

SUPT5H POLR2C

2.36e-041173231045206
Pubmed

Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.

BRD2 EID1

2.36e-041173215949438
Pubmed

Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain.

NRG1 APC

2.36e-041173222412988
Pubmed

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

NFKBIA ZAP70

2.36e-041173212190313
Pubmed

Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin.

IGF1R TJP1

2.36e-041173222479204
Pubmed

Targeting HIV transcription: the quest for a functional cure.

SUPT5H SMARCA2

2.36e-041173225731772
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

HDAC3 USP5 HBS1L GBF1 ZZZ3 BRD2 LEO1 SUPT5H SCIMP DENND4C

2.62e-041242731030973865
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

HDAC3 IGF1R TJP1 SMARCA2 APC MCM3 GNAS SSRP1 HNRNPLL CNOT3

2.70e-041247731027684187
Pubmed

AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

RALBP1 NFKBIA

2.83e-041273215310755
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

BRD2 MAP1B TJP1 SUPT5H MCM3 GNAS SSRP1 PQBP1 MAP4K4

2.88e-04102473924711643
Pubmed

Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.

NRG1 COL7A1 CSPG5

3.07e-046273319367581
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

USP5 TJP1 SUPT5H POLR2C SMARCA2 GNAS SSRP1

3.10e-0461573731048545
Pubmed

Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.

SOX6 TLE2

3.34e-041373222735158
InteractionCSNK2B interactions

ERCC6 BRD2 LEO1 TJP1 SUDS3 SUPT5H RALBP1 NFKBIA APC SSRP1 ATAD2 MAP4K4

2.00e-066257212int:CSNK2B
InteractionELOF1 interactions

IGF1R BRD2 LEO1 SUPT5H POLR2C

5.48e-0671725int:ELOF1
InteractionH2BC21 interactions

C2CD3 ZZZ3 BRD2 LEO1 MAP1B SUPT5H POLR2C CFDP1 MCM3 SSRP1 ATAD2 MAP4K4

6.02e-066967212int:H2BC21
InteractionCSNK2A1 interactions

HDAC3 GBF1 BRD2 LEO1 PRCC SUDS3 SUPT5H NFKBIA CFDP1 APC MCM3 ZNF428 SSRP1 ATAD2

6.07e-069567214int:CSNK2A1
InteractionEP300 interactions

RPF1 HDAC3 USP5 HBS1L IGF1R LEO1 PRCC SUDS3 SUPT5H NFKBIA CFDP1 EID1 SMARCA2 MCM3 SSRP1 JMY CNOT3

6.52e-0614017217int:EP300
InteractionPOLR2A interactions

ERCC6 LEO1 SUPT5H RALBP1 POLR2C NFKBIA SMARCA2 MCM3 SSRP1 PQBP1

1.99e-055367210int:POLR2A
InteractionMTA3 interactions

SOX6 IGF1R ERCC6 BRD2 SUDS3 SSRP1

3.59e-05173726int:MTA3
InteractionE2F2 interactions

EAPP BRD2 ATAD2 JMY

4.45e-0555724int:E2F2
InteractionNCOR1 interactions

SOX6 HDAC3 SUPT5H NFKBIA SMARCA2 SSRP1 HNRNPLL TRIM52

4.50e-05363728int:NCOR1
InteractionTOP2B interactions

HDAC3 ERCC6 BRD2 SMARCA2 SSRP1 RUBCN TRIM52

4.57e-05266727int:TOP2B
InteractionTASOR interactions

SUPT5H POLR2C SSRP1 HNRNPLL TRIM52

4.62e-05110725int:TASOR
InteractionGOLGA1 interactions

GBF1 APC CEP152 SMCR8 JMY DENND4C

4.91e-05183726int:GOLGA1
InteractionSNRPA interactions

LEO1 MAP1B SUPT5H POLR2C ARIH2 SSRP1 PQBP1 CTSL HNRNPLL

5.32e-05482729int:SNRPA
InteractionCDK2AP1 interactions

HDAC3 ERCC6 BRD2 LEO1 SUDS3

6.47e-05118725int:CDK2AP1
InteractionH3C1 interactions

HDAC3 BRIP1 ERCC6 BRD2 LEO1 RALBP1 CFDP1 EID1 SMARCA2 SSRP1 ATAD2 PQBP1

7.66e-059017212int:H3C1
InteractionE2F1 interactions

ZZZ3 EAPP BRD2 SMARCA2 ATAD2 JMY

8.03e-05200726int:E2F1
InteractionHOOK3 interactions

HBS1L TJP1 RALBP1 APC RUBCN TRIM52

8.49e-05202726int:HOOK3
InteractionBANF1 interactions

BRD2 RALBP1 SMARCA2 ZNF428 SSRP1 CTSL

8.96e-05204726int:BANF1
InteractionCOL7A1 interactions

BMP1 COL7A1 NFKBIA

9.50e-0525723int:COL7A1
InteractionSUPT4H1 interactions

LEO1 SUPT5H SMARCA2 SSRP1

9.68e-0567724int:SUPT4H1
InteractionTCEA1 interactions

LEO1 SUPT5H POLR2C NFKBIA MCM3

1.06e-04131725int:TCEA1
InteractionACTR3 interactions

ERCC6 TJP1 SMARCA2 APC CEP152 CTSL JMY

1.08e-04305727int:ACTR3
InteractionPOLR2E interactions

NPHP1 ERCC6 LEO1 SUPT5H POLR2C ARIH2 SSRP1

1.15e-04308727int:POLR2E
InteractionPAF1 interactions

ERCC6 LEO1 SUPT5H SSRP1 HNRNPLL CNOT3

1.16e-04214726int:PAF1
InteractionHDAC3 interactions

SOX6 HDAC3 BRIP1 IGF1R SUPT5H NFKBIA HNRNPLL

1.27e-04313727int:HDAC3
InteractionTERF2IP interactions

BRIP1 ZZZ3 LEO1 TJP1 PRCC SUPT5H CFDP1 SSRP1 PQBP1

1.49e-04552729int:TERF2IP
InteractionINTS15 interactions

GBF1 SUPT5H SSRP1

1.49e-0429723int:INTS15
InteractionPPP4R1 interactions

HDAC3 RALBP1 TLE2 POLR2C

1.58e-0476724int:PPP4R1
InteractionTOP1 interactions

ERCC6 BRD2 LEO1 SUPT5H RALBP1 POLR2C CFDP1 MCM3 SSRP1 PQBP1

1.76e-046967210int:TOP1
InteractionCTR9 interactions

ERCC6 LEO1 SUPT5H POLR2C SSRP1 TRIM52

1.85e-04233726int:CTR9
InteractionANKFY1 interactions

KIF1A TLE2 CEP152 SSRP1 MAP4K4 JMY

1.98e-04236726int:ANKFY1
InteractionRTF1 interactions

BRD2 LEO1 SUPT5H SSRP1 CNOT3

2.00e-04150725int:RTF1
InteractionPOLR2J interactions

SUPT5H POLR2C NFKBIA SSRP1 TRIM52

2.13e-04152725int:POLR2J
InteractionPOLR2D interactions

ERCC6 SUPT5H POLR2C MCM3 SSRP1

2.19e-04153725int:POLR2D
InteractionRAD18 interactions

USP5 ZRSR2P1 BRD2 LEO1 TJP1 MCM3 GNAS SSRP1

2.21e-04457728int:RAD18
InteractionNR0B2 interactions

HDAC3 EID1 SMARCA2 ZAP70

2.22e-0483724int:NR0B2
InteractionGJA1 interactions

IGF1R GBF1 MAP1B TJP1 CCDC47 APC SMCR8 MAP4K4 DENND4C

2.24e-04583729int:GJA1
InteractionSLC35G1 interactions

SUPT5H SMARCA2 APC

2.42e-0434723int:SLC35G1
InteractionPIPSL interactions

RPF1 HBS1L KIF1A MCM3 SMCR8 DENND4C

2.82e-04252726int:PIPSL
InteractionSETD5 interactions

SUPT5H SSRP1 SPAG16

3.11e-0437723int:SETD5
InteractionRASA1 interactions

IGF1R NFKBIA APC MAP4K4 ZAP70

3.29e-04167725int:RASA1
InteractionHMGB1 interactions

PPP2R3A MAP1B TJP1 RALBP1 TLE2 SMARCA2 ZNF428 SSRP1

3.34e-04486728int:HMGB1
InteractionDDA1 interactions

ZZZ3 LEO1 PRCC SUPT5H MCM3 SSRP1 PQBP1

3.40e-04368727int:DDA1
InteractionH2AZ1 interactions

BRD2 SUDS3 SUPT5H CFDP1 JAZF1 SSRP1 MAP4K4

3.57e-04371727int:H2AZ1
InteractionPOLR2B interactions

ERCC6 BRD2 SUPT5H POLR2C NFKBIA SSRP1 TRIM52

3.57e-04371727int:POLR2B
InteractionADAMTS1 interactions

BMP1 IGF1R BRD2 CTSL

3.73e-0495724int:ADAMTS1
InteractionCENPA interactions

ERCC6 BRD2 LEO1 CCDC47 SMARCA2 SSRP1 ATAD2

3.93e-04377727int:CENPA
InteractionCRNKL1 interactions

ERCC6 EAPP PRCC SUPT5H SSRP1

4.29e-04177725int:CRNKL1
InteractionWDR76 interactions

BRD2 MAP1B SUPT5H SSRP1 ATAD2 HNRNPLL TRIM52

4.32e-04383727int:WDR76
InteractionH2BC1 interactions

HDAC3 CFDP1 SMARCA2 JAZF1 SSRP1

4.41e-04178725int:H2BC1
InteractionZRSR2P1 interactions

ZRSR2P1 ZRSR2

4.46e-049722int:ZRSR2P1
InteractionPOLR2G interactions

ERCC6 LEO1 SUPT5H POLR2C SSRP1

4.52e-04179725int:POLR2G
InteractionCEP152 interactions

KIF1A TJP1 CEP152 MAP4K4 CNOT3

4.52e-04179725int:CEP152
InteractionLEO1 interactions

ERCC6 BRD2 LEO1 SUPT5H POLR2C SSRP1

4.76e-04278726int:LEO1
CytobandEnsembl 112 genes in cytogenetic band chr15q21

LEO1 EID1 UNC13C CEP152

1.89e-04177734chr15q21
Cytoband15q21.1

EID1 CEP152

1.60e-033773215q21.1
CoexpressionGSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN

NRG1 USP5 IGF1R ZRSR2 TJP1 SH3BP2 ARIH2

1.26e-06196737M7672
CoexpressionLAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_SMALL_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP

NPHP1 HDAC3 FOXRED2 BRIP1 KIF1A CSPG5 JAZF1 MCM3 REV3L SSRP1 ATAD2

2.73e-066807311MM456
CoexpressionWANG_TUMOR_INVASIVENESS_UP

BRD2 CCDC47 SUPT5H RALBP1 NFKBIA EID1 GNAS LRRC17

1.16e-05384738M1865
CoexpressionWANG_TUMOR_INVASIVENESS_UP

BRD2 CCDC47 SUPT5H RALBP1 NFKBIA EID1 GNAS LRRC17

1.61e-05402738MM1248
CoexpressionPYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP

BRIP1 ZRSR2 SUDS3 MCM3 CEP152 ATAD2

1.77e-05195736M13736
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_1000

USP5 BRD2 EID1 SMARCA2 MCM3 CNOT3 LRRC17

3.29e-06184737gudmap_developingGonad_e14.5_ epididymis_1000_k2
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX6 TLE2 CSPG5 GNAS REV3L ATAD2

6.23e-0718673610565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 BMP1 IGF1R GBF1 KIF1A DENND4C

8.21e-07195736bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NRG1 BRIP1 CSPG5 CCDC15 MCM3 ATAD2

9.24e-071997361d5a3366474c17e3df0ba5cf11b586655529e9bd
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRIP1 CCDC15 MCM3 CEP152 ATAD2

1.56e-0519173550854384fdaa0efa2e3227659d544ed09ac102f2
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BRIP1 CCDC15 MCM3 CEP152 ATAD2

1.72e-05195735b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BRIP1 CCDC15 MCM3 CEP152 ATAD2

1.72e-0519573556d8734d020b3da08a5aa9e67999706a9e023a99
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

BRIP1 CCDC15 MCM3 CEP152 ATAD2

1.76e-05196735df366d76ea55f49e349d622effa57c1535df8400
ToppCellBiopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

BRIP1 SLC2A4RG CSPG5 MCM3 ATAD2

1.89e-051997354fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PPP2R3A MAP1B KIF1A TJP1 PRR18

1.89e-051997355d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PPP2R3A MAP1B KIF1A TJP1 PRR18

1.89e-051997359dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PPP2R3A MAP1B KIF1A TJP1 PRR18

1.89e-051997356fb5f931e6217142de38c1fffc011e63bda4772b
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BRIP1 CCDC15 MCM3 CEP152 ATAD2

1.89e-0519973598575fcce726589e93fbb4df1aab03e57cb56076
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BRIP1 MAP1B MCM3 CEP152 ATAD2

1.89e-05199735be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PPP2R3A MAP1B KIF1A TJP1 PRR18

1.89e-051997351bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell10x_3'_v2v3-Neoplastic|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX6 MAP1B CSPG5 ZNF428 GNAS

1.94e-05200735e9c7d7cb5fa63fc92aa91d02ae8bd05438d465bc
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell|GW08 / Sample Type, Dataset, Time_group, and Cell type.

BRIP1 MCM3 CEP152 ATAD2 CNOT3

1.94e-052007354e077aa7faddcebdfc54667f8b3990704441005b
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BRIP1 CCDC15 MCM3 CEP152 ATAD2

1.94e-05200735af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

BRIP1 MCM3 CEP152 ATAD2 CNOT3

1.94e-05200735d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PPP2R3A MAP4K4 CTSL JMY

9.73e-05146734a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCellAdult-Immune-enucleated_erythrocyte-D175|Adult / Lineage, Cell type, age group and donor

COL7A1 RTL5 SUPT5H LRRC17

1.14e-04152734530d5427d8617dcb223d807b73abee0ef89285f3
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL7A1 MCM3 CEP152 ATAD2

1.39e-041607345cc1b75e3c20d83112b3aa2f3c749a6c73910a2d
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BRIP1 MCM3 ATAD2 ZAP70

1.52e-041647345621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 CCDC15 SSRP1 ATAD2

1.56e-0416573488681101d7cf60b99b8ace5d8c0944323b937306
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

COL7A1 FOXRED2 BRIP1 ATAD2

1.63e-041677343461d14e36f09ddc6ee5549ca4797e16d3f37fcc
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 UNC13C SCIMP ATAD2

1.67e-04168734a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXRED2 ZRSR2 CEP152 ZAP70

1.67e-04168734a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL7A1 ERCC6 KIF1A CPT1B

1.67e-04168734a8958b94ffc3423d56c250796dd253884b46f9d9
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)|Striatum / BrainAtlas - Mouse McCarroll V32

NRG1 EAPP CCDC47 PQBP1

1.71e-04169734c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 BRIP1 MCM3 CEP152

1.71e-04169734a1efc20e34a81ae32f8d278a5486811ade03ef24
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--|Striatum / BrainAtlas - Mouse McCarroll V32

NRG1 EAPP CCDC47 PQBP1

1.71e-041697345375eb52ebadccb7bfff997a11985f23e81014d6
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-|Striatum / BrainAtlas - Mouse McCarroll V32

NRG1 EAPP CCDC47 PQBP1

1.71e-041697341c132d21255f5a5174ac38db4e91927f9093418e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 MAP1B CCDC15 ATAD2

1.79e-04171734b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 MAP1B CCDC15 ATAD2

1.79e-04171734b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGF1R MAP1B KIF1A GNAS

1.95e-04175734e99e145a152f534b75267ec492a252a0b814b4f8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 MCM3 ATAD2 PRR18

2.04e-04177734f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX6 BMP1 MAP1B PRCC

2.04e-041777346b4fe717928814dafcd13090b1c90ea973938c6d
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B NFKBIA GNAS CTSL

2.04e-04177734ea2c2d2d7ffd34780882299229ff8614fdd7c79c
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B NFKBIA GNAS CTSL

2.04e-0417773463b5ebbe505f22091bc7b0db818e01fae5d92bb7
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

SOX6 PRUNE2 NRG1 PPP2R3A

2.08e-04178734544379f5a6145429762258d426b876bb36c112f5
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 NRG1 MAP1B KIF1A

2.08e-0417873430ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCelldroplet-Lung-nan-18m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF1R UNC13C ZAP70 DENND4C

2.13e-041797348ebd0c7ac99ac8194fa1a2aac88a893739a97725
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF1R UNC13C ZAP70 DENND4C

2.17e-0418073481c7086399256260e59424b7410feec514ce8027
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGF1R UNC13C ZAP70 DENND4C

2.22e-04181734c7ad10a696d94b9ee91cd7e62761d356d5106eda
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGF1R UNC13C ZAP70 DENND4C

2.22e-04181734eaa3a2c268cce527004ae656d35e037b984fb4c7
ToppCellPBMC-Control-cDC_12|Control / Compartment, Disease Groups and Clusters

BRIP1 SLC2A4RG MCM3 ATAD2

2.27e-041827344774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Cycling_T|Liver / Manually curated celltypes from each tissue

BRIP1 MCM3 ATAD2 LRRC17

2.27e-0418273481557cdc88777f3bd4e1dd18a760b08fc29122ef
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 BMP1 MAP1B ZNF428

2.32e-04183734ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|lymph-node_spleen / Manually curated celltypes from each tissue

PRUNE2 BRIP1 CCDC15 LRRC17

2.36e-04184734f93373fcde5c31f4ffe67ca0f3ea7f4e906dc88b
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 MAP1B KIF1A RTL5

2.36e-041847343da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX6 PRUNE2 CSPG5 ZNF428

2.36e-04184734278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX6 PRUNE2 CSPG5 ZNF428

2.36e-041847348d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 NRG1 KIF1A PRR18

2.46e-04186734c7983281a290201567b398e9ea6baddb96c692bb
ToppCellNasal_Brush-Immune-Neutrophils|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

IGF1R SLC2A4RG TLE2 SMCR8

2.46e-04186734f5aa91dbef29f7efa2b9a728c6539d7541340cd4
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 PPP2R3A JAZF1 SPAG16

2.46e-04186734f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 PPP2R3A JAZF1 SPAG16

2.51e-04187734c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

SOX6 PRUNE2 NRG1 PPP2R3A

2.51e-04187734d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 UNC13C CEP152 ATAD2

2.51e-04187734057569c9437219ecc396aa6e673b1178a2273837
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 PPP2R3A JAZF1 SPAG16

2.57e-04188734af740fa78542438fdff627ea1f74f4eee43316be
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX6 PRUNE2 CSPG5 ZNF428

2.57e-04188734006db2c2c44971ca9241c582bc89f258c785f5ed
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX6 PRUNE2 CSPG5 ZNF428

2.57e-04188734d0e6fb4a3b3d79d3512b5500062ea285495ae526
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 NRG1 KIF1A PRR18

2.67e-04190734b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 BMP1 MAP1B DENND4C

2.72e-04191734f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 GBF1 KIF1A DENND4C

2.78e-041927345b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX6 MAP1B ZNF428 REV3L

2.78e-041927341d0d6fb89a2b941b7caab2f1f07d6bd5433a11e7
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 GBF1 KIF1A DENND4C

2.83e-04193734471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 GBF1 KIF1A DENND4C

2.83e-04193734fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX6 PRUNE2 PPP2R3A IGF1R

2.83e-041937343866667dd221612589ae50f5c52f73a183a49ce6
ToppCellfacs-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 MAP1B KIF1A GNAS

2.83e-0419373415c86e20b97b6983410b36d308cddff56d141c98
ToppCellNon-neuronal-Non-dividing|World / Primary Cells by Cluster

SOX6 CSPG5 SPAG16 LRRC17

2.89e-041947340add09d97192b34bd506209ab5f1a77182f498fc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SOX6 PRUNE2 PPP2R3A IGF1R

2.89e-041947347002937e8903e037332a215d00fbc7c7843b33f2
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRUNE2 MAP1B ZRSR2 CFDP1

2.89e-041947348985095f291c1b54e45f4edece49aa26e8c8b732
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 CSPG5 MCM3 ATAD2

2.89e-041947344c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 MAP1B KIF1A DENND4C

2.89e-041947340b023de48ed8a550d169bbe954881eb04bf4f981
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NPHP1 CEP152 REV3L SSRP1

2.89e-04194734dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|Liver / Manually curated celltypes from each tissue

SLC2A4RG SMARCA2 GNAS JMY

2.95e-04195734972b09697b7b66fb8a27dfc0c0b05a844121f055
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BRIP1 CCDC15 MCM3 CEP152

2.95e-04195734cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo|Liver / Manually curated celltypes from each tissue

SLC2A4RG BRD2 SMARCA2 GNAS

2.95e-04195734c29c4ae95a756e3ced0f0747bbfe343590e5b8ab
ToppCellControl-Lymphoid-CD4_T_cells|Lymphoid / Condition, Lineage and Cell class

TLE2 NFKBIA CTSL ZAP70

2.95e-041957348679a122fe796b1eddef82460e985b3fd3b3a2a5
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-basal_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL7A1 SMARCA2 GNAS CTSL

2.95e-04195734eaadc79f53b1cb208c6f7999925f318e1378197f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX6 PPP2R3A RALBP1 UNC13C

3.01e-04196734c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

BRIP1 CCDC15 MCM3 CEP152

3.01e-041967341d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BRIP1 CCDC15 CEP152 ATAD2

3.06e-0419773484ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SOX6 PRUNE2 PPP2R3A SPAG16

3.06e-041977347e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BRIP1 CCDC15 MCM3 CEP152

3.06e-041977348b616cde333bdbc0c591035ad9e4949155866245
ToppCellILEUM-non-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SOX6 PRUNE2 NRG1 MAP1B

3.06e-041977344e0c3ea4f4a04a41532806edf3bccf7845c86fa5
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

MAP1B ZRSR2 CFDP1 CEP152

3.06e-041977340fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NRG1 MAP1B TJP1 SH3BP2

3.06e-041977347870c0651caefb0ed13d9f9dab43b5f24d6a9efc
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

TJP1 CCDC47 RALBP1 SMARCA2

3.12e-0419873476d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellHealthy_Control-Myeloid-Macrophages-FCN1+SPP1+|Healthy_Control / Condition, Lineage, Cell class and cell subclass

BRD2 NFKBIA MAP4K4 DENND4C

3.12e-04198734aa90326b82e21de37af5642df6a70a8b21af7f04
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

RALBP1 SMARCA2 REV3L JMY

3.18e-0419973418a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.

SOX6 KIF1A SMARCA2 APC

3.18e-04199734b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCellCOVID-19_Mild-T/NK_proliferative|COVID-19_Mild / Disease condition and Cell class

BRIP1 MCM3 CEP152 ATAD2

3.18e-041997349f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCellCOVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative|COVID-19_Severe / Disease group, lineage and cell class

BRIP1 MCM3 SSRP1 ATAD2

3.18e-04199734ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

MAP1B RALBP1 SMARCA2 REV3L

3.18e-04199734c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellILEUM-non-inflamed-(8)_Smooth_muscle_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SOX6 PRUNE2 NRG1 MAP1B

3.18e-041997343368c0a90a47c4dcdfe70be3192550df0744e508
ToppCellCOVID-19_Severe-T/NK_proliferative|COVID-19_Severe / disease group, cell group and cell class

BRIP1 CCDC15 MCM3 ATAD2

3.18e-04199734af78837f3a7641a5bd98765eef9cb4f86034048c
ToppCell10x_3'_v2v3-Neoplastic-Stem-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX6 MAP1B CSPG5 ZNF428

3.18e-0419973494baf00dad27964392c3fc34970a4e79d576d0d3
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

BRIP1 MCM3 CEP152 ATAD2

3.24e-042007348f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

USP5 MCM3 CEP152 ATAD2

3.24e-04200734d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells|10w / Sample Type, Dataset, Time_group, and Cell type.

BRIP1 MCM3 CEP152 ATAD2

3.24e-04200734a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
DrugDyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A

BMP1 PPP2R3A POLR2C ARIH2 CEP152 TRIM52 DENND4C

3.17e-061967377022_DN
DrugEthopropazine hydrochloride [1094-08-2]; Up 200; 11.4uM; PC3; HT_HG-U133A

TJP1 TLE2 NFKBIA APC ZNF428 CNOT3

3.34e-051907366697_UP
DrugPiribedil hydrochloride [78213-63-5]; Down 200; 12uM; MCF7; HT_HG-U133A

KIF1A POLR2C APC GNAS CPT1B PQBP1

3.44e-051917365434_DN
DrugGW8510; Up 200; 10uM; MCF7; HT_HG-U133A

BMP1 USP5 HBS1L KIF1A TLE2 GNAS

3.54e-051927367062_UP
Drug(1)-Nipecotic acid [498-95-3]; Down 200; 31uM; HL60; HT_HG-U133A

BMP1 GBF1 SUPT5H CSPG5 SH3BP2 ARIH2

3.97e-051967363121_DN
DrugHydroquinine hydrobromide hydrate [304695-81-6]; Down 200; 9.4uM; MCF7; HT_HG-U133A

FOXRED2 KIF1A POLR2C ARIH2 SMARCA2 CEP152

3.97e-051967366263_DN
DrugHydrastine hydrochloride [5936-28-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A

BMP1 HBS1L PPP2R3A MAP1B POLR2C CEP152

3.97e-051967362889_DN
DrugOxantel pamoate [68813-55-8]; Up 200; 6.6uM; MCF7; HT_HG-U133A

BMP1 COL7A1 MAP1B APC CEP152 TRIM52

3.97e-051967365338_UP
DrugFlutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A

COL7A1 PPP2R3A KIF1A APC GNAS CNOT3

4.09e-051977363885_DN
DrugSulfamonomethoxine [1220-83-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A

COL7A1 GBF1 RALBP1 SH3BP2 POLR2C CPT1B

4.09e-051977363484_UP
Drug5186223; Down 200; 12uM; MCF7; HT_HG-U133A_EA

BMP1 USP5 PPP2R3A SH3BP2 ARIH2 CEP152

4.09e-05197736885_DN
DrugLithocholic acid [434-13-9]; Up 200; 10.6uM; MCF7; HT_HG-U133A

NPHP1 BMP1 COL7A1 TLE2 SMARCA2 CPT1B

4.21e-051987363433_UP
DrugMonensin sodium salt [22373-78-0]; Down 200; 5.8uM; HL60; HT_HG-U133A

BMP1 SLC2A4RG KIF1A CSPG5 SH3BP2 RUBCN

4.21e-051987362580_DN
DrugEpicatechin-(-) [154-23-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A

BMP1 HBS1L CSPG5 SH3BP2 POLR2C ZNF428

4.21e-051987362815_DN
DrugNicergoline; Down 200; 8.2uM; MCF7; HT_HG-U133A

USP5 HBS1L MAP1B SUPT5H APC DENND4C

4.33e-051997362220_DN
DrugTiclopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; MCF7; HT_HG-U133A

PPP2R3A FOXRED2 CSPG5 POLR2C ARIH2 CEP152

4.33e-051997361475_DN
DrugMetformin hydrochloride [1115-70-4]; Down 200; 24.2uM; PC3; HT_HG-U133A

BMP1 PPP2R3A ARIH2 ZNF428 CPT1B CNOT3

4.33e-051997365068_DN
DrugBetaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; HL60; HG-U133A

TXNDC15 SLC2A4RG PRCC CCDC47 ARIH2 MAP4K4

4.45e-052007361592_DN
DrugFlorfenicol [73231-34-2]; Up 200; 11.2uM; PC3; HT_HG-U133A

COL7A1 SH3BP2 SMARCA2 APC ZNF428 PQBP1

4.45e-052007366701_UP
DiseaseGrowth Disorders

IGF1R ERCC6 PQBP1

8.63e-0536703C0018273
Diseasedementia (is_implicated_in)

NRG1 IGF1R

3.61e-0412702DOID:1307 (is_implicated_in)
DiseaseAlzheimer's disease (is_marker_for)

NRG1 BRIP1 IGF1R APC GNAS

3.68e-04257705DOID:10652 (is_marker_for)
Diseasecolorectal cancer (is_marker_for)

HDAC3 BRIP1 ERCC6 MAP4K4

5.38e-04157704DOID:9256 (is_marker_for)
Diseasecryptococcosis

MCM3 JMY

5.71e-0415702EFO_0007229
Diseasethyroid volume

IGF1R SMARCA2

6.52e-0416702EFO_0004865
Diseasehepatocellular carcinoma (is_implicated_in)

IGF1R NFKBIA APC MAP4K4

9.16e-04181704DOID:684 (is_implicated_in)
DiseaseGiant Cell Glioblastoma

BRD2 NFKBIA APC

1.06e-0384703C0334588
Diseasecholangiocarcinoma (is_implicated_in)

APC GNAS

1.24e-0322702DOID:4947 (is_implicated_in)
Diseasesciatic neuropathy (implicated_via_orthology)

NRG1 NFKBIA

1.36e-0323702DOID:11446 (implicated_via_orthology)
DiseaseColorectal Carcinoma

COL7A1 ZZZ3 ERCC6 MAP1B APC GNAS PQBP1

1.37e-03702707C0009402
Diseasetyrosine measurement

NRG1 PPP2R3A JAZF1

1.96e-03104703EFO_0005058
Diseaseasthma

SLC2A4RG BRD2 NFKBIA SMARCA2 JAZF1 UNC13C MAP4K4

2.01e-03751707MONDO_0004979
Diseasehyperthyroidism (biomarker_via_orthology)

IGF1R CTSL

2.02e-0328702DOID:7998 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PVQNEDEEYDEEDYE

CEP152

11

O94986
YPTTSFYDDLDEEEE

CSPG5

266

O95196
PYPTDNEDYEHDDED

SH3BP2

166

P78314
DDYDPYAVEEPSDEE

EAPP

6

Q56P03
EEEEDDPGDIEDYYV

ARIH2

26

O95376
SDLAYSDDDVPSVYE

ATAD2

746

Q6PL18
ADYTYDLAEEDDSEP

BMP1

26

P13497
DPPVDLSSDEEYYVE

CAVIN4

166

Q5BKX8
DSEGEESEYFPTEEE

ERCC6

366

Q03468
DVEYYVDSSQDPDFE

CNOT3

206

O75175
AYDREESTNLEDYEP

RALBP1

246

Q15311
SSPRETYEEDREYES

HNRNPLL

6

Q8WVV9
DKPSVEPVEEYDYED

HBS1L

46

Q9Y450
EPVEEYDYEDLKESS

HBS1L

51

Q9Y450
EDEEYETTQEYEPAQ

NRG1

521

Q02297
DSEGEESEYFPTEEE

ERCC6

366

P0DP91
YEYSGSEEEEEEVPE

MAP4K4

321

O95819
SASYLEPDRYDEEEE

LEO1

566

Q8WVC0
EETTRSPDEEDYDYE

MAP1B

1876

P46821
SPDEEDYDYESYEKT

MAP1B

1881

P46821
TETDDPEEYYESLSE

JMY

311

Q8N9B5
PAYPESFDQDTEDDE

LRRC17

406

Q8N6Y2
YPDLYPQEDEDEEEE

CHCHD4

101

Q8N4Q1
TPTGSEYDEEEVDYE

JAZF1

126

Q86VZ6
DTESEPYDDEEFEGY

CCDC47

91

Q96A33
DTYNITDPEELETEY

IGF1R

761

P08069
EDDYDYPEEEQLSGA

EID1

106

Q9Y6B2
PESEDEESYDTESEF

NFKBIA

281

P25963
EYAEGYESVSVDPED

FOXRED2

196

Q8IWF2
FEDYETDEPASPSEF

PPP2R3A

1111

Q06190
EEAISEELPYSEYFE

HDAC3

316

O15379
EDESIYFTPELYDPE

BRIP1

1126

Q9BX63
YFTPELYDPEDTDEE

BRIP1

1131

Q9BX63
DGDSYDPYDFSDTEE

MCM3

701

P25205
EEIIAEDYDDDPVDY

PQBP1

26

O60828
EDYDDDPVDYEATRL

PQBP1

31

O60828
SEDFSTSEEDEDYVP

CFDP1

6

Q9UEE9
EDTEAGPAYSDEDYE

C2CD3

2051

Q4AC94
GPAYSDEDYEEDIIE

C2CD3

2056

Q4AC94
LEYEEEFDYETESET

GNAS

101

O95467
YSDDEEETNRDYSFP

DENND4C

1386

Q5VZ89
VTPDEETYDEEDAAF

GBF1

1141

Q92538
EEERVPPEDDEYSEY

COL7A1

2841

Q02388
PPEDDEYSEYSEYSV

COL7A1

2846

Q02388
SLESYLSDYEEEPAE

RUBCN

946

Q92622
YDDVEYEEEPEAVDE

PRR18

246

Q8N4B5
LDEESYSYDPEDEAS

CPT1B

421

Q92523
YLEPYSEEEEGQESS

NPHP1

206

O15259
RYYPEVNEEEEEPED

KIF1A

681

Q12756
PSPNEEESEDEEYYS

RTL5

331

Q5HYW3
DELDTPDEADSFEYT

PRUNE2

2836

Q8WUY3
IPSYIEPEDDYDDVE

SCIMP

121

Q6UWF3
PRSDSEESDSDYEEE

SMARCA2

631

P51531
YASSDESEPDEAEPE

PRCC

6

Q92733
RAEEEYEYAFDDEPT

SUPT5H

831

O00267
SEYSELDEDESQAPY

POLR2C

206

P19387
TKEEEYEEEPYNEPA

SMCR8

11

Q8TEV9
PSYDEYADSDEDQHD

SSRP1

436

Q08945
DYEDDPKSDYSSENE

SOX6

806

P35712
YDSEEEEESRPMSYD

BRD2

631

P25440
LDSEESYPYEATEES

CTSL

196

P07711
QELDYEEPDYEESSS

CCDC15

251

Q0P6D6
QEDDYEDDKPTNYSE

APC

1131

P25054
EEDDDYENSTPPYKD

CLEC17A

21

Q6ZS10
EEEDDDYENSTPPYK

CLEC17A

46

Q6ZS10
EEEEDDDYENSTPPY

CLEC17A

71

Q6ZS10
AYDEDEDEELYPDIH

TRIM52

156

Q96A61
EEEETTDDPEYDPGY

ZNF428

51

Q96B54
YDETTVDPNDEEVAY

RPF1

111

Q9H9Y2
DTSVYESPYSDPEEL

ZAP70

311

P43403
DYTEPVADNETDYVE

UNC13C

866

Q8NB66
SDPEKDEDDDDNYYI

REV3L

2101

O60673
EPEQSDGEEDFYYTE

SLC2A4RG

231

Q9NR83
EASEDDYEYEEIPDD

SPAG16

51

Q8N0X2
PDREEEYYTEPEVAE

TXNDC15

141

Q96J42
PEPVSDNEEDSYDEE

TJP1

121

Q07157
RDDYDPDASLEYSEE

ZRSR2P1

221

Q15695
EYYPEEDEELESAED

SUDS3

21

Q9H7L9
EPSGPYESDEDKSDY

TLE2

221

Q04725
HITEEEDDDPDVYYF

ZZZ3

476

Q8IYH5
EDDDPDVYYFESDHV

ZZZ3

481

Q8IYH5
RDDYDPDASLEYSEE

ZRSR2

216

Q15696
ITPDGADVYSYDEDD

USP5

251

P45974