Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of microtubule plus-end binding	MAPRE1 MAPRE3	1.76e-05	2	87	2	GO:1903033
GeneOntologyBiologicalProcess	regulation of microtubule plus-end binding	MAPRE1 MAPRE3	1.76e-05	2	87	2	GO:1903031
GeneOntologyBiologicalProcess	membraneless organelle assembly	TUBB1 MAPRE1 MRPS7 MAPRE3 SMC1A ASPM FASTKD2 MYOM2 INO80 NEB	3.13e-05	475	87	10	GO:0140694
GeneOntologyBiologicalProcess	spindle assembly	TUBB1 MAPRE1 MAPRE3 SMC1A ASPM INO80	4.65e-05	153	87	6	GO:0051225
GeneOntologyBiologicalProcess	muscle organ development	RB1 DSP FRG1 MYOM2 DMD NEB MCUB ZFPM2 RYR2	9.27e-05	436	87	9	GO:0007517
GeneOntologyCellularComponent	mitotic spindle astral microtubule end	MAPRE1 MAPRE3	5.24e-05	3	88	2	GO:1905721
GeneOntologyCellularComponent	supramolecular fiber	TUBB1 MAPRE1 MAPRE3 KRT7 EFCAB6 MYO5A DSP COL28A1 FRG1 ASPM MYOM2 INO80 DMD NEB RYR2	1.11e-04	1179	88	15	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	TUBB1 MAPRE1 MAPRE3 KRT7 EFCAB6 MYO5A DSP COL28A1 FRG1 ASPM MYOM2 INO80 DMD NEB RYR2	1.20e-04	1187	88	15	GO:0099081
GeneOntologyCellularComponent	mitotic spindle astral microtubule	MAPRE1 MAPRE3	4.83e-04	8	88	2	GO:0061673
GeneOntologyCellularComponent	matrix side of mitochondrial inner membrane	PAM16 DMD	4.83e-04	8	88	2	GO:0099617
GeneOntologyCellularComponent	microtubule end	MAPRE1 MAPRE3 ASPM	5.47e-04	38	88	3	GO:1990752
GeneOntologyCellularComponent	mitotic spindle pole	MAPRE1 SMC1A ASPM	7.88e-04	43	88	3	GO:0097431
GeneOntologyCellularComponent	astral microtubule	MAPRE1 MAPRE3	9.40e-04	11	88	2	GO:0000235
GeneOntologyCellularComponent	smooth endoplasmic reticulum	MYO5A APOB RYR2	9.60e-04	46	88	3	GO:0005790
GeneOntologyCellularComponent	aster	MAPRE1 MAPRE3	1.13e-03	12	88	2	GO:0005818
Domain	Rb_C	RB1 RBL1	2.10e-05	2	86	2	PF08934
Domain	EB1_C	MAPRE1 MAPRE3	6.27e-05	3	86	2	IPR004953
Domain	RB_A	RB1 RBL1	6.27e-05	3	86	2	IPR002720
Domain	DUF3452	RB1 RBL1	6.27e-05	3	86	2	PF11934
Domain	RB_B	RB1 RBL1	6.27e-05	3	86	2	IPR002719
Domain	RB_A	RB1 RBL1	6.27e-05	3	86	2	PF01858
Domain	RB_B	RB1 RBL1	6.27e-05	3	86	2	PF01857
Domain	EB1_C	MAPRE1 MAPRE3	6.27e-05	3	86	2	PS51230
Domain	RB_C	RB1 RBL1	6.27e-05	3	86	2	IPR015030
Domain	RB_fam	RB1 RBL1	6.27e-05	3	86	2	IPR028309
Domain	MAPRE	MAPRE1 MAPRE3	6.27e-05	3	86	2	IPR027328
Domain	DUF3452	RB1 RBL1	6.27e-05	3	86	2	SM01367
Domain	Rb_C	RB1 RBL1	6.27e-05	3	86	2	SM01369
Domain	RB_A	RB1 RBL1	6.27e-05	3	86	2	SM01368
Domain	EB1	MAPRE1 MAPRE3	6.27e-05	3	86	2	PF03271
Domain	RB_N	RB1 RBL1	6.27e-05	3	86	2	IPR024599
Domain	P-loop_NTPase	ORC4 PALS1 ERCC6 RAB24 MYO5A SMC1A RHOBTB3 ASPM ERCC6L2 GBP1 ARL9 INO80 MFN1	1.28e-04	848	86	13	IPR027417
Domain	CH	MAPRE1 MAPRE3 ASPM DMD	3.05e-04	70	86	4	PF00307
Domain	-	MAPRE1 MAPRE3 ASPM DMD	3.22e-04	71	86	4	1.10.418.10
Domain	CH	MAPRE1 MAPRE3 ASPM DMD	3.58e-04	73	86	4	PS50021
Domain	CH-domain	MAPRE1 MAPRE3 ASPM DMD	3.97e-04	75	86	4	IPR001715
Domain	SNF2_N	ERCC6 ERCC6L2 INO80	4.25e-04	32	86	3	IPR000330
Domain	SNF2_N	ERCC6 ERCC6L2 INO80	4.25e-04	32	86	3	PF00176
Domain	-	ORC4 PALS1 ERCC6 RAB24 SMC1A RHOBTB3 ERCC6L2 GBP1 ARL9 INO80 MFN1	6.13e-04	746	86	11	3.40.50.300
Domain	aa-tRNA-synth_II	KARS1 TARS1	3.06e-03	18	86	2	IPR006195
Domain	AA_TRNA_LIGASE_II	KARS1 TARS1	3.06e-03	18	86	2	PS50862
Domain	Zinc_finger_PHD-type_CS	TRIM33 PHF20 KDM2A	3.35e-03	65	86	3	IPR019786
Domain	IQ	RASGRF1 MYO5A ASPM	4.30e-03	71	86	3	PF00612
Domain	PAS_fold_3	PER3 NPAS4	4.98e-03	23	86	2	IPR013655
Domain	PAS_3	PER3 NPAS4	4.98e-03	23	86	2	PF08447
Domain	PAS-assoc_C	PER3 NPAS4	5.42e-03	24	86	2	IPR000700
Domain	Znf_PHD-finger	TRIM33 PHF20 KDM2A	5.79e-03	79	86	3	IPR019787
Domain	IQ	RASGRF1 MYO5A ASPM	6.21e-03	81	86	3	SM00015
Domain	PAC	PER3 NPAS4	6.34e-03	26	86	2	PS50113
Domain	-	GUCA1C EFCAB6 PPP2R3B DMD RYR2	7.13e-03	261	86	5	1.10.238.10
Domain	Spectrin_repeat	DSP DMD	7.85e-03	29	86	2	IPR002017
Domain	PHD	TRIM33 PHF20 KDM2A	8.05e-03	89	86	3	SM00249
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MRPS7 PRPF31 KARS1 ERCC6 UBN1 IPO7 MYO5A RB1 DSP SMC1A ASPM SNX27 KDM2A FASTKD2 PRR14L TARS1	2.60e-07	1353	88	16	29467282
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ORC4 PRPF31 ERCC6 UBN1 IPO7 RB1 FRG1 SMC1A KDM2A INO80 ARID3B	4.04e-07	608	88	11	36089195
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SMG1 KARS1 IPO7 DSP SMC1A TBK1 ANKRD26 KDM2A MYOM2 NEB	5.41e-07	497	88	10	23414517
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	INTS10 MAPRE1 MRPS7 MAPRE3 KARS1 IPO7 DSP SMC1A TBK1 CTNNA1 DMD TARS1	9.43e-07	809	88	12	32129710
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ORC4 TRIM33 PRPF31 PRDM10 RB1 DSP RBL1 SMC1A PARG KDM2A FOXA1 ARID3B	1.71e-06	857	88	12	25609649
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TUBB1 MAPRE1 PRPF31 MAPRE3 WBP11 KARS1 RB1 RBL1 SMC1A TBK1 SNX27 PAM16 CTNNA1 ARID3B	5.65e-06	1321	88	14	27173435
Pubmed	Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.	DMD RYR2	6.33e-06	2	88	2	26555638
Pubmed	Interaction of mouse adenovirus type 1 early region 1A protein with cellular proteins pRb and p107.	RB1 RBL1	6.33e-06	2	88	2	8862413
Pubmed	EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.	MAPRE1 MAPRE3	6.33e-06	2	88	2	28814570
Pubmed	Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells.	MAPRE1 MAPRE3	6.33e-06	2	88	2	25761518
Pubmed	p107 is a suppressor of retinoblastoma development in pRb-deficient mice.	RB1 RBL1	6.33e-06	2	88	2	9620848
Pubmed	A novel tumor suppressor network in squamous malignancies.	RB1 RBL1	6.33e-06	2	88	2	23145321
Pubmed	EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms.	MAPRE1 MAPRE3	6.33e-06	2	88	2	21768326
Pubmed	FOXA1 and CK7 expression in esophageal squamous cell carcinoma and its prognostic significance.	KRT7 FOXA1	6.33e-06	2	88	2	29788741
Pubmed	Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells.	RB1 RBL1	6.33e-06	2	88	2	8197461
Pubmed	End binding proteins are obligatory dimers.	MAPRE1 MAPRE3	6.33e-06	2	88	2	24040250
Pubmed	The decrease of expression of ryanodine receptor sub-type 2 is reversed by gentamycin sulphate in vascular myocytes from mdx mice.	DMD RYR2	6.33e-06	2	88	2	19298530
Pubmed	FOXA1 promotes proliferation, migration and invasion by transcriptional activating KRT7 in human gastric cancer cells.	KRT7 FOXA1	6.33e-06	2	88	2	31317696
Pubmed	Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha.	RB1 RBL1	6.33e-06	2	88	2	16271529
Pubmed	Retinoblastoma susceptibility gene product (pRb) and p107 functionally separate the requirements for serum and anchorage in the cell cycle G1-phase.	RB1 RBL1	6.33e-06	2	88	2	14732703
Pubmed	Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.	RB1 RBL1	6.33e-06	2	88	2	18300254
Pubmed	Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics.	MAPRE1 MAPRE3	6.33e-06	2	88	2	24478452
Pubmed	Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation.	RB1 RBL1	6.33e-06	2	88	2	8386265
Pubmed	Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.	MAPRE1 MAPRE3	6.33e-06	2	88	2	18230754
Pubmed	p107 regulates neural precursor cells in the mammalian brain.	RB1 RBL1	6.33e-06	2	88	2	15353549
Pubmed	Cytoskeletal mechanics of proplatelet maturation and platelet release.	TUBB1 MAPRE3	6.33e-06	2	88	2	21079248
Pubmed	Mammalian end binding proteins control persistent microtubule growth.	MAPRE1 MAPRE3	6.33e-06	2	88	2	19255245
Pubmed	Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin.	DSP CTNNA1	6.33e-06	2	88	2	11239416
Pubmed	Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy.	DMD RYR2	6.33e-06	2	88	2	30181262
Pubmed	Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action.	RB1 RBL1	6.33e-06	2	88	2	25249236
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	MRPS7 KARS1 MYO5A DSP SMC1A CTNNA1 TARS1 MFN1	8.08e-06	399	88	8	37536630
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MAPRE1 TRIM33 PRPF31 WBP11 KARS1 UBN1 IPO7 RB1 SMC1A KDM2A INO80 TARS1	9.48e-06	1014	88	12	32416067
Pubmed	DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells.	MAPRE1 ORC4 MAPRE3 KARS1 RB1	1.29e-05	118	88	5	26264872
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	RB1 DSP APOB RYR2	1.36e-05	57	88	4	23788249
Pubmed	Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.	RB1 RBL1	1.90e-05	3	88	2	19887614
Pubmed	The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells.	RB1 RBL1	1.90e-05	3	88	2	19509021
Pubmed	p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2.	RB1 RBL1	1.90e-05	3	88	2	15827088
Pubmed	Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions.	MYO5A DMD	1.90e-05	3	88	2	22815846
Pubmed	Molecular insights into mammalian end-binding protein heterodimerization.	MAPRE1 MAPRE3	1.90e-05	3	88	2	20008324
Pubmed	The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression.	RB1 RBL1	1.90e-05	3	88	2	17936268
Pubmed	Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine.	RB1 RBL1	1.90e-05	3	88	2	18981186
Pubmed	Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis.	KRT7 FOXA1	1.90e-05	3	88	2	20043065
Pubmed	Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a.	RB1 RBL1	1.90e-05	3	88	2	21515735
Pubmed	The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9.	CYP1A2 MYO5A	1.90e-05	3	88	2	7490103
Pubmed	Targeted disruption of p107: functional overlap between p107 and Rb.	RB1 RBL1	1.90e-05	3	88	2	8682293
Pubmed	Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions.	RB1 RBL1	1.90e-05	3	88	2	11114893
Pubmed	Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.	RB1 RBL1	1.90e-05	3	88	2	11114892
Pubmed	Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.	RB1 RBL1	1.90e-05	3	88	2	20019750
Pubmed	A role for the Rb family of proteins in controlling telomere length.	RB1 RBL1	1.90e-05	3	88	2	12379853
Pubmed	Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.	RB1 RBL1	1.90e-05	3	88	2	27966456
Pubmed	The first knockout mouse model of retinoblastoma.	RB1 RBL1	1.90e-05	3	88	2	15190215
Pubmed	EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue.	MAPRE1 MAPRE3	1.90e-05	3	88	2	10644998
Pubmed	The retinoblastoma gene family is differentially expressed during embryogenesis.	RB1 RBL1	1.90e-05	3	88	2	9150384
Pubmed	Interaction between human cyclin A and adenovirus E1A-associated p107 protein.	RB1 RBL1	1.90e-05	3	88	2	1532458
Pubmed	pRB plays an essential role in cell cycle arrest induced by DNA damage.	RB1 RBL1	1.90e-05	3	88	2	9751770
Pubmed	Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE.	KRT7 DSP	1.90e-05	3	88	2	37660597
Pubmed	The retinoblastoma gene family in differentiation and development.	RB1 RBL1	1.90e-05	3	88	2	10630640
Pubmed	A critical temporal requirement for the retinoblastoma protein family during neuronal determination.	RB1 RBL1	1.90e-05	3	88	2	9508781
Pubmed	Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.	RB1 RBL1	1.90e-05	3	88	2	19887370
Pubmed	Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.	DMD RYR2	1.90e-05	3	88	2	20615971
Pubmed	Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry.	RB1 RBL1	1.90e-05	3	88	2	12853964
Pubmed	Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.	RBL1 PPP2R3B	1.90e-05	3	88	2	9927208
Pubmed	Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice.	RB1 RBL1	1.90e-05	3	88	2	17956737
Pubmed	pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.	RB1 RBL1	1.90e-05	3	88	2	9192872
Pubmed	FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells.	SMC1A FOXA1	1.90e-05	3	88	2	27739523
Pubmed	Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.	RB1 RBL1	1.90e-05	3	88	2	12621062
Pubmed	Regulation of RB transcription in vivo by RB family members.	RB1 RBL1	1.90e-05	3	88	2	20100864
Pubmed	Activation of NF-kB pathway by virus infection requires Rb expression.	RB1 RBL1	1.90e-05	3	88	2	19649275
Pubmed	Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice.	RB1 RBL1	1.90e-05	3	88	2	26317218
Pubmed	Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis.	RB1 RBL1	1.90e-05	3	88	2	15148303
Pubmed	Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells.	RB1 KDM2A	1.90e-05	3	88	2	25029110
Pubmed	A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses.	PALS1 SNX27	1.90e-05	3	88	2	36298757
Pubmed	A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.	RB1 RBL1	1.90e-05	3	88	2	15210943
Pubmed	Neuronal differentiation and synaptogenesis in retinoblastoma.	RB1 RBL1	1.90e-05	3	88	2	17363591
Pubmed	Animal models in retinoblastoma research.	RB1 RBL1	1.90e-05	3	88	2	24227978
Pubmed	p107 acts as a tumor suppressor in pRb-deficient epidermis.	RB1 RBL1	1.90e-05	3	88	2	17932945
Pubmed	Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy.	DMD RYR2	1.90e-05	3	88	2	20080623
Pubmed	Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.	RB1 RBL1	1.90e-05	3	88	2	19341623
Pubmed	Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.	RB1 ARID3B	1.90e-05	3	88	2	10446990
Pubmed	Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters.	RB1 RBL1	1.90e-05	3	88	2	19279001
Pubmed	Cross-species genomic and epigenomic landscape of retinoblastoma.	RB1 RBL1	1.90e-05	3	88	2	23765217
Pubmed	Expression of the retinoblastoma family of tumor suppressors during murine embryonic orofacial development.	RB1 RBL1	1.90e-05	3	88	2	12627794
Pubmed	Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.	MAPRE1 DSP	1.90e-05	3	88	2	25225338
Pubmed	Genes in the RB pathway and their knockout in mice.	RB1 RBL1	1.90e-05	3	88	2	9110405
Pubmed	MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells.	MAPRE1 MAPRE3	1.90e-05	3	88	2	23572079
Pubmed	Changes in retinoblastoma cell adhesion associated with optic nerve invasion.	RB1 RBL1	1.90e-05	3	88	2	19786571
Pubmed	Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.	RB1 RBL1	1.90e-05	3	88	2	36413521
Pubmed	Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer.	RB1 RBL1	1.90e-05	3	88	2	22942253
Pubmed	Pocket proteins suppress head and neck cancer.	RB1 RBL1	1.90e-05	3	88	2	22237625
Pubmed	Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma.	RB1 RBL1	1.90e-05	3	88	2	15193257
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MRPS7 PRPF31 KARS1 ERCC6 MYO5A FRG1 SMC1A ASPM ZC3H7B ARID3B	2.25e-05	759	88	10	35915203
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	TRIM33 WBP11 IPO7 FRG1 SMC1A CTNNA1 ZFPM2 ARID3B	2.58e-05	469	88	8	27634302
Pubmed	Ras protects Rb family null fibroblasts from cell death: a role for AP-1.	RB1 RBL1	3.79e-05	4	88	2	14688262
Pubmed	Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.	RB1 RBL1	3.79e-05	4	88	2	21840489
Pubmed	A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.	RB1 RBL1	3.79e-05	4	88	2	15467457
Pubmed	Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma.	RB1 RBL1	3.79e-05	4	88	2	35954335
Pubmed	The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.	RB1 RBL1	3.79e-05	4	88	2	16286473
Pubmed	Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding.	RB1 RBL1	3.79e-05	4	88	2	11521194
Pubmed	High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.	RB1 RBL1	3.79e-05	4	88	2	24086435
Pubmed	Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1.	RB1 RBL1	3.79e-05	4	88	2	17620057
Interaction	CDH5 interactions	SMG1 PTPRB MYO5A DSP ASPM CTNNA1	7.71e-06	109	87	6	int:CDH5
Cytoband	1q31	ASPM RGS1	6.08e-04	19	88	2	1q31
Cytoband	14q23.3	PALS1 PPP1R36	1.15e-03	26	88	2	14q23.3
Cytoband	10q11.23	ERCC6 PARG	1.85e-03	33	88	2	10q11.23
Cytoband	5q15	ARSK RHOBTB3	2.70e-03	40	88	2	5q15
Cytoband	Ensembl 112 genes in cytogenetic band chr2q23	ORC4 NEB	4.70e-03	53	88	2	chr2q23
Cytoband	Ensembl 112 genes in cytogenetic band chr5q15	ARSK RHOBTB3	5.79e-03	59	88	2	chr5q15
Cytoband	22q13.2	EFCAB6 ZC3H7B	5.98e-03	60	88	2	22q13.2
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	TRIM33 SMG1 PRDM10 RB1 NBEAL1 SMC1A KDM2A PRR14L	1.70e-07	180	88	8	M8239
Coexpression	GSE17721_CTRL_VS_GARDIQUIMOD_1H_BMDC_DN	CYP1A2 ORC4 KLHL2 SLC26A8 DSP RBL1 ANKRD26	5.10e-06	200	88	7	M3777
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 EFCAB6 APOB MYOM2 DMD NEB RYR2	8.19e-08	184	88	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 EFCAB6 APOB MYOM2 DMD NEB RYR2	8.19e-08	184	88	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 EFCAB6 APOB MYOM2 DMD NEB RYR2	8.19e-08	184	88	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 PALS1 UBN1 IPO7 DSP DMD	1.83e-06	185	88	6	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 GPR65 KICS2 FOXA1 RGS1	9.26e-06	142	88	5	58c2882cb0ede8cc5d84c85a650d28267268e748
Disease	brain glioma (is_marker_for)	PTPRB FOXA1	8.35e-05	5	86	2	DOID:0060108 (is_marker_for)
Disease	galectin-7 measurement	APOB ZFPM2	1.25e-04	6	86	2	EFO_0022034
Disease	Gastrointestinal Stromal Sarcoma	RB1 CTNNA1 DMD	3.53e-04	47	86	3	C3179349
Disease	arrhythmogenic right ventricular cardiomyopathy (is_implicated_in)	DSP RYR2	3.72e-04	10	86	2	DOID:0050431 (is_implicated_in)
Disease	Gastrointestinal Stromal Tumors	RB1 CTNNA1 DMD	4.24e-04	50	86	3	C0238198
Disease	anxiety	EFCAB6 ASB3 ERCC6L2 DMD ZC3H7B	4.99e-04	223	86	5	EFO_0005230
Disease	Sclerocystic Ovaries	MAPRE3 ASPM KICS2 DMD	8.47e-04	144	86	4	C1136382
Disease	Polycystic Ovary Syndrome	MAPRE3 ASPM KICS2 DMD	8.47e-04	144	86	4	C0032460
Disease	caffeine metabolite measurement	CYP1A2 ARID3B	1.39e-03	19	86	2	EFO_0007872
Disease	colorectal carcinoma (is_implicated_in)	ERCC6 PTPRB	1.87e-03	22	86	2	DOID:0080199 (is_implicated_in)
Disease	lung adenocarcinoma (is_marker_for)	ERCC6 PTPRB FOXA1	1.99e-03	85	86	3	DOID:3910 (is_marker_for)
Disease	glioblastoma (is_implicated_in)	PTPRB RB1	2.22e-03	24	86	2	DOID:3068 (is_implicated_in)
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	INTS10 APOB MCUB	2.73e-03	95	86	3	EFO_0004529, EFO_0008317, EFO_0008596
Disease	phosphatidylinositol measurement	PRPF31 SCARB2 APOB	2.73e-03	95	86	3	EFO_0010230
Disease	chylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement	INTS10 APOB MCUB	2.81e-03	96	86	3	EFO_0004530, EFO_0008317, EFO_0008596
Disease	pancreatic ductal adenocarcinoma (is_marker_for)	PTPRB GLIPR2	2.81e-03	27	86	2	DOID:3498 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AEKETQAASKYFHVQ	ARID3B	111	Q8IVW6
QAASKYFHVQKVARQ	ARID3B	116	Q8IVW6
VSASVHQYNKEQFIK	ARSK	476	Q6UWY0
TNSAEKFQINYDKHI	GVINP1	1936	Q7Z2Y8
EQSQHLFQAHKEKYD	ARFIP1	291	P53367
LVVFANKQDLEAAYH	ARL9	121	Q6T311
NHFKQVFSDVQAREK	DMD	916	P11532
DHQQFPRKENKEYAS	ANKRD26	591	Q9UPS8
EQHKVYQNFVDSKEV	ERCC6	771	Q03468
VINNQKEKEDFHSYL	ASPM	531	Q8IZT6
AHQIYQFTDKDKDNV	ADM	121	P35318
FHVDQSNYFLNFKKE	NBEAL1	1956	Q6ZS30
HECNIDEVKNVYFKN	RB1	281	P06400
FHDVQDYADNIKAQL	RAB24	136	Q969Q5
FFNIEKYLDHEQKEQ	PPP2R3B	471	Q9Y5P8
IYKAFVHSDAAKQIN	RGS1	136	Q08116
KTVQEHYQDFDKNSV	CYP1A2	266	P05177
DYDSNHFKAQALKNA	INO80	441	Q9ULG1
NNFDSEAHAKYKNQV	INTS10	296	Q9NVR2
HAKERAFKQQFVNYA	MFN1	636	Q8IWA4
NEFQKFVQRKAHSVY	ORC4	351	O43929
HYEVTIKNKNNFIQT	PTPRB	761	P23467
HFDVQQYNKLKEDLA	MCUB	296	Q9NWR8
FKNKYEDEINHRTAA	KRT7	176	P08729
ISFNKVENYLAHKQN	ZFPM2	861	Q8WW38
AHTQKEEQNYVDKFR	PER3	681	P56645
HYFCEVKFKSDQNLQ	IPO7	481	O95373
SSVQKDNFYQHNVEK	PARG	111	Q86W56
QAQYIDCFQKIKHSF	EPS8L3	281	Q8TE67
QKANKHIDQVYNTFD	GUCA1C	51	O95843
KDYAAIVEQNLQHFK	DSE	736	Q9UL01
QFEEIKEKDHQATYQ	LRP2BP	81	Q9P2M1
QIENSAAVQKAIAHY	GBP1	321	P32455
AASYAEFVNQKIHDI	PRDM10	326	Q9NQV6
NSLEKVVHFYDDKVQ	KICS2	376	Q96MD2
NKDFQNAFKIHNAIT	PALS1	156	Q8N3R9
QQHKLDFKAYEQALQ	FOXA1	411	P55317
PVKQSFFHYSEKEQN	NPAS4	616	Q8IUM7
EINYVKKFQSFQDHK	FRG1	206	Q14331
SAKTHNLNVEYNIFE	DPYSL4	421	O14531
AFVKYDKNQDVHSIN	APOB	2056	P04114
HIYEFVNHAIKAQAK	ASB3	376	Q9Y575
EEKLHTNKYNANFVT	KDM2A	41	Q9Y2K7
NYSHKVEKVANLKQF	COL28A1	841	Q2UY09
VKEYAQVFREHANKL	CTNNA1	416	P35221
NIHKDTAVDYNVFLK	EFCAB6	221	Q5THR3
SKQFHNEVLKAHNEY	GLIPR2	6	Q9H4G4
ANQHQHRTAEEKKYV	CASC2	16	Q6XLA1
RKIQSQFTDAQKHYQ	DSP	606	P15924
VKFQAKLEHEYIQNF	MAPRE1	61	Q15691
VKFQAKLEHEYIHNF	MAPRE3	61	Q9UPY8
KSVKFQNHISYREEV	ERCC6L2	1346	Q5T890
TKPEFNNHKDYAQEK	RYR2	1366	Q92736
VDNSLITKYENAFQH	PRR14L	816	Q5THK1
IVIKYNVNDKFSFHE	RHOBTB3	96	O94955
NVNDKFSFHEVKDNY	RHOBTB3	101	O94955
FLEENYSHQNAKKIV	PHF20	726	Q9BVI0
DEYAQKVRQQFHDAK	TARS1	631	P26639
KQFEKYHAASAEEQA	MRPS7	121	Q9Y2R9
LEKKNYVHFAATQVQ	TRIM33	331	Q9UPN9
RNYKSEEEFIHINNK	KARS1	161	Q15046
VEYNLQQHFEKKRSF	RBL1	351	P28749
KREVYNEETFQQEHK	SLC26A8	26	Q96RN1
LNHVYKCQNKEQFVE	FASTKD2	466	Q9NYY8
AFKNHVFNVDNAKFV	SMG1	596	Q96Q15
KAYQQKLFVTHTVDE	SCARB2	161	Q14108
HDLVSEYQQFQDAKA	TUBB1	416	Q9H4B7
NKAFVNVQKELAHFA	RBIS	51	Q8N0T1
KQHYFTVNFSHENQK	RASGRF1	91	Q13972
FQQTAYKIEHQAKVT	RASGRF1	1231	Q13972
QAFKNVVHKVVFYAN	OR6C3	296	Q9NZP0
KIHKQNENFYQFSVK	C12orf40	546	Q86WS4
KDHFKSQAEELQKQY	UBTFL1	266	P0CB47
AQYAFIHEDLNTVKA	RNASE10	136	Q5GAN6
QAAEKKVAEANQKYF	PRPF31	466	Q8WWY3
DTQFNYHRKKNIAAE	SMC1A	181	Q14683
KHVEQNGEKFVVYNV	SNX27	171	Q96L92
DNKAAQYFVKLHIIA	STAB2	426	Q8WWQ8
EKAQNVFEKKYHQVD	PPP1R36	326	Q96LQ0
VYQAVRHNKATENKE	GPR65	206	Q8IYL9
EEVQKNYEHLFKVND	PAM16	71	Q9Y3D7
AKYQDECQAHTQAKV	UBN1	461	Q9NPG3
FQCNKYVEVFHKISN	ZNF117	81	Q03924
FERKHENQQKQYICS	GTF3A	121	Q92664
ANLYEKYNHINAKDD	TTC37	81	Q6PGP7
YLTNENIEQAHEAFK	TTC37	871	Q6PGP7
LSQYFDAVKNAQHVE	WBP11	121	Q9Y2W2
KENDFKHFHSVIYIN	XRRA1	111	Q6P2D8
AYNEEQIHKFDKQKL	TBK1	576	Q9UHD2
KYSKIRQFQEHFQFD	ZC3H7B	601	Q9UGR2
KANTYAEQHFADVVL	KLHL2	176	O95198
KAFIIQHFADKVEYQ	MYO5A	546	Q9Y4I1
QLSEHFSVKVEQAKY	MYOM2	1386	P54296
KAQDVVSNVNYKHSL	NEB	1151	P20929