Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprocollagen-lysine 5-dioxygenase activity

PLOD3 PLOD1

3.32e-053672GO:0008475
GeneOntologyMolecularFunctionprocollagen glucosyltransferase activity

PLOD3 PLOD1

3.32e-053672GO:0033823
GeneOntologyMolecularFunctionpeptidyl-lysine 5-dioxygenase activity

PLOD3 PLOD1

6.63e-054672GO:0070815
GeneOntologyMolecularFunctionphosphorylase kinase activity

PHKA1 PHKA2

6.63e-054672GO:0004689
GeneOntologyMolecularFunctionDNA topoisomerase activity

TOP1 TOP2B

3.07e-048672GO:0003916
GeneOntologyMolecularFunctionnitrite reductase activity

CYGB MTARC2

5.98e-0411672GO:0098809
GeneOntologyCellularComponentseptin complex

SEPTIN8 SEPTIN11 SEPTIN10

1.12e-0514673GO:0031105
GeneOntologyCellularComponentseptin ring

SEPTIN8 SEPTIN11 SEPTIN10

1.12e-0514673GO:0005940
GeneOntologyCellularComponentseptin cytoskeleton

SEPTIN8 SEPTIN11 SEPTIN10

1.71e-0516673GO:0032156
GeneOntologyCellularComponenttenascin complex

TNN TNR

6.05e-054672GO:0090733
GeneOntologyCellularComponentphosphorylase kinase complex

PHKA1 PHKA2

1.01e-045672GO:0005964
MousePhenodecreased diameter of femur

COL12A1 CANT1 IL6ST

3.11e-0516553MP:0008152
DomainSeptin

SEPTIN8 SEPTIN11 SEPTIN10

1.07e-0513643PF00735
DomainG_SEPTIN_dom

SEPTIN8 SEPTIN11 SEPTIN10

1.07e-0513643IPR030379
DomainG_SEPTIN

SEPTIN8 SEPTIN11 SEPTIN10

1.07e-0513643PS51719
DomainTscrpt_reg_Wos2-domain

MYB MYBL1

1.16e-052642IPR012642
DomainLMSTEN

MYB MYBL1

1.16e-052642PF07988
DomainSeptin

SEPTIN8 SEPTIN11 SEPTIN10

1.36e-0514643IPR016491
Domainfn3

COL12A1 LRRN1 NRCAM TNN TNR IL6ST

1.92e-05162646PF00041
DomainGlyco_hydro_15

PHKA1 PHKA2

3.46e-053642PF00723
DomainCmyb_C

MYB MYBL1

3.46e-053642PF09316
DomainLYS_HYDROXYLASE

PLOD3 PLOD1

3.46e-053642PS01325
DomainGlyco_hydro_15/PHK

PHKA1 PHKA2

3.46e-053642IPR011613
DomainC-myb_C

MYB MYBL1

3.46e-053642IPR015395
DomainPHK_A/B_su

PHKA1 PHKA2

3.46e-053642IPR008734
DomainProcol_lys_dOase

PLOD3 PLOD1

3.46e-053642IPR001006
DomainFN3

COL12A1 LRRN1 NRCAM TNN TNR IL6ST

4.05e-05185646SM00060
DomainFN3

COL12A1 LRRN1 NRCAM TNN TNR IL6ST

6.08e-05199646PS50853
DomainFN3_dom

COL12A1 LRRN1 NRCAM TNN TNR IL6ST

7.98e-05209646IPR003961
DomainEGF_3

TNN TLL1 HABP2 C8B TNR LRP1B

1.52e-04235646PS50026
DomainEGF-like_dom

TNN TLL1 HABP2 C8B TNR LRP1B

2.08e-04249646IPR000742
DomainEGF_1

TNN TLL1 HABP2 C8B TNR LRP1B

2.36e-04255646PS00022
DomainEGF-like_CS

TNN TLL1 HABP2 C8B TNR LRP1B

2.67e-04261646IPR013032
DomainEGF_2

TNN TLL1 HABP2 C8B TNR LRP1B

2.90e-04265646PS01186
Domain6hp_glycosidase

PHKA1 PHKA2

3.19e-048642IPR012341
Domain-

PHKA1 PHKA2

3.19e-0486421.50.10.10
DomainHTH_MYB

MYB MYBL1

4.10e-049642PS51294
DomainMyb_dom

MYB MYBL1

4.10e-049642IPR017930
Domain6-hairpin_glycosidase-like

PHKA1 PHKA2

8.80e-0413642IPR008928
DomainEGF_extracell

TNN TNR LRP1B

1.14e-0360643IPR013111
DomainEGF_2

TNN TNR LRP1B

1.14e-0360643PF07974
DomainEGF

TNN TLL1 HABP2 TNR LRP1B

1.26e-03235645SM00181
DomainP4Hc

PLOD3 PLOD1

1.34e-0316642SM00702
DomainPro_4_hyd_alph

PLOD3 PLOD1

1.34e-0316642IPR006620
Domain2OG-FeII_Oxy

PLOD3 PLOD1

1.90e-0319642PF03171
DomainFE2OG_OXY

PLOD3 PLOD1

2.33e-0321642PS51471
DomainOxoglu/Fe-dep_dioxygenase

PLOD3 PLOD1

2.79e-0323642IPR005123
DomainVWFA

CPNE8 COL12A1 ITIH5

2.80e-0382643PS50234
DomainVWA

CPNE8 COL12A1 ITIH5

3.00e-0384643SM00327
DomainFibrinogen_a/b/g_C_2

TNN TNR

3.04e-0324642IPR014715
Domain-

TNN TNR

3.04e-03246424.10.530.10
DomainTUDOR

TDRD7 PHF19

3.84e-0327642SM00333
DomainFibrinogen_C

TNN TNR

3.84e-0327642PF00147
DomainFBG

TNN TNR

4.42e-0329642SM00186
DomainTudor

TDRD7 PHF19

4.73e-0330642IPR002999
Domain-

TNN TNR

4.73e-03306423.90.215.10
DomainFibrinogen_a/b/g_C_1

TNN TNR

4.73e-0330642IPR014716
DomainVWF_A

CPNE8 COL12A1 ITIH5

4.76e-0399643IPR002035
DomainFIBRINOGEN_C_1

TNN TNR

5.37e-0332642PS00514
DomainFibrinogen_a/b/g_C_dom

TNN TNR

5.37e-0332642IPR002181
DomainFIBRINOGEN_C_2

TNN TNR

5.37e-0332642PS51406
DomainMyb_DNA-binding

MYB MYBL1

6.39e-0335642PF00249
PathwayREACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

PHKA1 PHKA2 PYGL

1.58e-0514513MM15391
PathwayREACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

PHKA1 PHKA2 PYGL

1.58e-0514513M19193
PathwayREACTOME_GLYCOGEN_METABOLISM

PHKA1 PHKA2 PYGL

3.50e-0518513MM15577
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

COL12A1 PLOD3 TLL1 PLOD1

6.81e-0561514MM14637
PathwayREACTOME_GLYCOGEN_METABOLISM

PHKA1 PHKA2 PYGL

9.70e-0525513M27857
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

COL12A1 PLOD3 TLL1 PLOD1

9.84e-0567514M26999
PathwayREACTOME_COLLAGEN_FORMATION

COL12A1 PLOD3 TLL1 PLOD1

1.61e-0476514MM14573
PathwayWP_GLYCOGEN_METABOLISM

PHKA1 PHKA2 PYGL

2.47e-0434513MM15985
PathwayREACTOME_COLLAGEN_FORMATION

COL12A1 PLOD3 TLL1 PLOD1

3.09e-0490514M631
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL12A1 PLOD3 TNN TLL1 PLOD1 TNR

3.20e-04258516MM14572
PathwayWP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION

PHKA1 PHKA2 PYGL

4.01e-0440513M39595
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL12A1 PLOD3 TNN TLL1 PLOD1 TNR

7.11e-04300516M610
Pubmed

Adenoid cystic carcinoma of the Bartholin's gland is underpinned by MYB- and MYBL1- rearrangements.

MYB MYBL1

3.66e-06267238368814
Pubmed

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

MYB MYBL1

3.66e-06267231563982
Pubmed

Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.

TOP1 TOP2B

3.66e-06267225815590
Pubmed

X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase.

PHKA1 PHKA2

3.66e-0626728733133
Pubmed

Cloning and characterization of a third human lysyl hydroxylase isoform.

PLOD3 PLOD1

3.66e-0626729724729
Pubmed

Inhibitory effect of conjugated eicosapentaenoic acid on human DNA topoisomerases I and II.

TOP1 TOP2B

3.66e-06267215680922
Pubmed

The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution.

PHKA1 PHKA2

3.66e-0626728226841
Pubmed

Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.

PLOD3 PLOD1

3.66e-06267234304093
Pubmed

Expression of mouse c-myb during embryonic development.

MYB MYBL1

3.66e-0626728570177
Pubmed

Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases.

MYB MYBL1

3.66e-06267236074655
Pubmed

Arrest of spermatogenesis and defective breast development in mice lacking A-myb.

MYB MYBL1

3.66e-0626729109487
Pubmed

MYB and MYBL1 in adenoid cystic carcinoma: diversity in the mode of genomic rearrangement and transcripts.

MYB MYBL1

3.66e-06267229410490
Pubmed

A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.

MYB MYBL1

3.66e-06267231595312
Pubmed

cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis.

PHKA1 PHKA2

3.66e-0626721372435
Pubmed

DNA binding and transactivation activity of A-myb, a c-myb-related gene.

MYB MYBL1

3.66e-0626727987850
Pubmed

Detecting MYB and MYBL1 fusion genes in tracheobronchial adenoid cystic carcinoma by targeted RNA-sequencing.

MYB MYBL1

3.66e-06267231028361
Pubmed

Localization of septin proteins in the mouse cochlea.

SEPTIN8 SEPTIN11 SEPTIN10

3.76e-061667322575789
Pubmed

Androglobin, a chimeric mammalian globin, is required for male fertility.

SEPTIN8 SEPTIN11 SEPTIN10

6.48e-061967335700329
Pubmed

Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma.

PLOD3 PLOD1

1.10e-05367231446433
Pubmed

The myb gene family in cell growth, differentiation and apoptosis.

MYB MYBL1

1.10e-05367210378697
Pubmed

Septin expression in proliferative retinal membranes.

SEPTIN8 SEPTIN11

1.10e-05367217625225
Pubmed

Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3).

PLOD3 PLOD1

1.10e-0536729582318
Pubmed

Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5.

SEPTIN8 SEPTIN11

1.10e-05367216767699
Pubmed

MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene.

MYB MYBL1

1.10e-05367229149504
Pubmed

The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult.

PLOD3 PLOD1

1.10e-05367216996725
Pubmed

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities.

TOP1 TOP2B

1.10e-0536729049244
Pubmed

The genes encoding mouse lysyl hydroxylase isoforms map to chromosomes 4,5, and 9.

PLOD3 PLOD1

1.10e-05367211130984
Pubmed

Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse.

PLOD3 PLOD1

1.10e-05367210429951
Pubmed

Mammalian septins nomenclature.

SEPTIN8 SEPTIN10

1.10e-05367212475938
Pubmed

Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3).

PLOD3 PLOD1

1.10e-05367211896059
Pubmed

Overexpression of Lewis(y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the upregulation of Topo-I and Topo-II β.

TOP1 TOP2B

1.10e-05367221542140
Pubmed

Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity.

PLOD3 PLOD1

1.10e-05367211956192
Pubmed

Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity.

MYB MYBL1

1.10e-05367210660576
Pubmed

Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase.

PHKA1 PHKA2

1.10e-05367212876330
Pubmed

Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity.

PLOD3 PLOD1

1.10e-05367210934207
Pubmed

PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.

PLOD3 PLOD1

2.19e-05467233483598
Pubmed

A possible implication of reduced levels of LIF, LIFR, and gp130 in vasculopathy related to systemic sclerosis.

FLI1 IL6ST

2.19e-05467229038846
Pubmed

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.

PLOD3 PLOD1

2.19e-05467216467571
Pubmed

Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease.

PHKA1 PHKA2

2.19e-0546721872871
Pubmed

Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice.

PHKA1 PHKA2

2.19e-0546723472241
Pubmed

Temporal patterns of A-myb and B-myb gene expression during testis development.

MYB MYBL1

2.19e-0546728808690
Pubmed

Phosphorylase Kinase Deficiency

PHKA1 PHKA2

2.19e-05467221634085
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

PLOD3 DDX50 DYRK1A PAK1IP1 PLOD1 TOP2B RPS6KC1

2.24e-0544067734244565
Pubmed

A protein interaction landscape of breast cancer.

PLOD3 DDX50 PHF19 DHPS PAK1IP1 SEPTIN10 PLOD1 TOP2B

2.96e-0563467834591612
Pubmed

Location of phosphorylase kinase (Phk) in the mouse X chromosome.

PHKA1 PHKA2

3.64e-0556724726088
Pubmed

The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3.

MYB MYBL1

5.46e-05667216055500
Pubmed

Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.

PLOD3 PLOD1

7.63e-05767215377789
Pubmed

A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation.

TOP1 TOP2B

1.02e-04867233188014
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

SEPTIN8 SEPTIN11 SEPTIN10 NOL8

1.02e-0412567429467281
Pubmed

Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.

SEPTIN8 SEPTIN11

1.30e-04967218809578
Pubmed

DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse.

SEPTIN8 SEPTIN11

1.63e-041067235200715
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

KNTC1 SEPTIN8 DNAH3 GINS3 SEPTIN11 IDE SEPTIN10 TOP1

2.20e-0484767835235311
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

GHITM PYGL IDE TOP1 TARBP2

2.20e-0428367521903422
Pubmed

Chromosomal localization of opioid peptide and receptor genes in the mouse.

TOP1 MYB

2.38e-04126727752808
Pubmed

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

MOXD1 DYRK1A HABP2 IDE PLOD1

2.97e-0430267530561431
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

COL12A1 PLOD3 PLOD1 ITIH5

3.11e-0416767422159717
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DAB2IP SEPTIN8 UBE2O NRCAM SEPTIN11 NDUFA9 SEPTIN10 LRP1B RPS6KC1

3.26e-04113967936417873
Pubmed

Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.

PHKA1 PHKA2

3.28e-04146728432533
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

SEPTIN8 DDX50 DHPS TOP2B

3.32e-0417067416159877
Pubmed

A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome.

CES1 MYB

4.31e-04166722571572
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

KNTC1 GINS3 UBE2O PAFAH1B3 DHPS SEPTIN11 PYGL IDE SEPTIN10 PLOD1

4.50e-041455671022863883
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

CPNE8 UBE2O PLOD3 GHITM DHPS NDUFA9 PLOD1 TARBP2 TOP2B NOL8

5.33e-041487671033957083
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

CPNE8 DYRK1A LRP1B IL6ST

6.01e-0419967423382691
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

UBE2O DDX50 IDE TARBP2 TOP2B

6.93e-0436467524778252
Pubmed

Directed proteomic analysis of the human nucleolus.

DDX50 SEPTIN11 TOP1 TOP2B

7.10e-0420867411790298
Pubmed

Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.

IL6ST MYB

8.24e-04226729324354
Pubmed

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.

GINS3 UBE2O DDX50 TOP1

8.74e-0422067431822558
Pubmed

The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.

CYGB GRM8 TNR

9.12e-049867319554387
Pubmed

Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.

PHKA2 PYGL

9.82e-042467217937387
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

DDX50 TOP1 TOP2B

1.05e-0310367332744500
Pubmed

Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.

TOP2B IL6ST

1.07e-032567229379870
Pubmed

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.

PHKA2 MOXD1 GHITM NDUFA9 TOP1 TOP2B

1.09e-0360467637616343
Pubmed

Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.

SEPTIN8 LRRN1

1.15e-032667215890332
Pubmed

Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.

SEPTIN8 SEPTIN11 SEPTIN10

1.21e-0310867319531213
Pubmed

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

GINS3 PAFAH1B3 TOP1 TOP2B

1.30e-0324567419521500
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

DDX50 SEPTIN11 PAK1IP1 NOL8

1.36e-0324867427926873
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

DAB2IP SEPTIN8 SEPTIN11 NDUFA9 TNR

1.45e-0343067532581705
Pubmed

Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.

SLC25A27 IDE NDUFA9

1.52e-0311767318977241
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

NRCAM TNN C8B IL6ST

1.55e-0325767416335952
Pubmed

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

SLC25A27 IDE NDUFA9

1.60e-0311967317601350
Pubmed

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.

PHKA2 PYGL

1.64e-033167214684825
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SEPTIN8 TARS3 UBE2O NRCAM DYRK1A SEPTIN11 NDUFA9 TNR TOP1

1.64e-03143167937142655
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

PLOD3 PAK1IP1 SEPTIN10 PLOD1 TOP1 TOP2B

1.71e-0366067632780723
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KNTC1 DDX50 CES1 TNN ASIC5 SEPTIN10 TOP1 TOP2B RPS6KC1

1.73e-03144267935575683
Pubmed

Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome.

PLOD3 PLOD1

1.75e-033267236920550
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

PHKA1 PHKA2 GBP6 PLOD3 DHPS DYRK1A PLOD1

1.83e-0391067736736316
Pubmed

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.

PLOD1 MYB

1.86e-033367218424556
Cytoband16q22.2

CES1 HYDIN

4.76e-042267216q22.2
GeneFamilySeptins

SEPTIN8 SEPTIN11 SEPTIN10

3.05e-0613413732
GeneFamilyFibronectin type III domain containing

COL12A1 NRCAM TNN TNR IL6ST

2.95e-05160415555
GeneFamilyTopoisomerases

TOP1 TOP2B

7.48e-0564121050
GeneFamilyFibrinogen C domain containing

TNN TNR

1.46e-0325412554
GeneFamilyTudor domain containing

TDRD7 PHF19

3.18e-0337412780
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

MYB MYBL1

6.43e-0353412532
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CPNE8 COL12A1 TLL1 ASIC5 GRM8 LRP1B

2.98e-07179676b35a7f8115c997c390201da01d7cb10b10769aec
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SLC25A27 MOXD1 NRCAM SEPTIN11 IL6ST ITIH5

5.54e-0719967630d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 TLL1 PAFAH1B3 LRP1B HYDIN

4.32e-06160675c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 TLL1 PAFAH1B3 LRP1B HYDIN

4.32e-0616067525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE8 MOXD1 TARS3 TLL1 ZNF235

5.48e-0616867532e4d82efaccf336d347e4063253c3635a3ec672
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TARS3 CYGB SEPTIN11 TNR MYBL1

6.68e-061756750ed053aa8353c72ff37fee830672704a3ddc7d85
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TARS3 CYGB SEPTIN11 TNR MYBL1

6.68e-061756750124a3c4696b39cee8b566e94603d1d3d128bfa5
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TARS3 CYGB SEPTIN11 TNR MYBL1

6.68e-06175675e219b61d6bc078d44ea7d06191d3462654d857a1
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TARS3 CYGB SEPTIN11 TNR MYBL1

6.68e-06175675bd16c80418bf71127e6f1e50edf83967c9218b42
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 MOXD1 NRCAM CYGB ITIH5

7.87e-061816759e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH3 CATSPERE CES1 HYDIN MYB

8.08e-06182675975f6275777fc578eba528e50f69891c66ec44ad
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH3 CATSPERE CES1 HYDIN MYB

8.08e-06182675f8c28fa76751062c4cfba0db8af1b377f947f739
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CPNE8 COL12A1 TLL1 GRM8 LRP1B

8.52e-061846759cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CPNE8 MOXD1 TLL1 CYGB IL6ST

9.45e-061886755eb107122064f0a99dfd445cc87d3766f7257216
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CPNE8 MOXD1 TLL1 CYGB IL6ST

9.95e-06190675e1b721bb74561fe51c53328a0394c9954e489049
ToppCellCOVID-19-Myeloid-TRAM1|Myeloid / Condition, Lineage and Cell class

CES1 SEPTIN11 C8B ITIH5 MYB

1.07e-051936756e6a7f4e50c8ae70bc187b9ce77140a7049dd288
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL12A1 CYGB SEPTIN11 GRM8 ITIH5

1.07e-05193675dd4bac8a93a5b9dcf7301f1d7d6e3eb6670f5c68
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL12A1 CYGB SEPTIN11 GRM8 ITIH5

1.07e-051936752ddf9b2770a0be9689e01d1a3d19e4a6d42c7a50
ToppCell367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MOXD1 COL12A1 TNN SEPTIN11 PLOD1

1.21e-05198675c55608633f66e3d434c5d81324efb07c5120d2c2
ToppCell367C-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MOXD1 COL12A1 TNN SEPTIN11 PLOD1

1.21e-051986753e5459038fc6ed95f529eb4d1dc5113e16c19012
ToppCellILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CPNE8 COL12A1 CYGB IL6ST ITIH5

1.24e-0519967556d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPNE8 COL12A1 CYGB IL6ST ITIH5

1.27e-05200675c5d818203bef80ff97c2e0158cf61970673dd258
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E-|Neuronal / cells hierarchy compared to all cells using T-Statistic

CPNE8 COL12A1 TLL1 GRM8 LRP1B

1.27e-052006751a3d29a580d1b405a74869a1da3e818c581fc559
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E---L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

CPNE8 COL12A1 TLL1 GRM8 LRP1B

1.27e-052006756f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E--|Neuronal / cells hierarchy compared to all cells using T-Statistic

CPNE8 COL12A1 TLL1 GRM8 LRP1B

1.27e-0520067586705dfc05b3e1576543b93883c88fb55b742855
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E|Neuronal / cells hierarchy compared to all cells using T-Statistic

CPNE8 COL12A1 TLL1 GRM8 LRP1B

1.27e-05200675db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

SLC25A27 MOXD1 NRCAM SEPTIN11 ITIH5

1.27e-05200675bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

CES1 SEPTIN11 PNLDC1 C8B

6.08e-05141674399380de5ea09e22fd128e3e55fffeffc4874c15
ToppCelldroplet-Lung-nan-3m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 PHF19 ZPBP GSTCD

9.92e-051606748a7a73b0ee1877fe02d47f745d36ae2858b529e1
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated|Liver / Manually curated celltypes from each tissue

KNTC1 SEPTIN10 IL6ST MYB

1.14e-041666749afa33b5ad27dc33576be592f9b22d8161366838
ToppCellIonocyte-iono-3|World / Class top

KNTC1 MOXD1 TARBP2 ITIH5

1.14e-041666749c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 LRRN1 MYB MYBL1

1.17e-0416767450c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L3-5_THEMIS_UBE2F|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 TLL1 ASIC5 GRM8

1.20e-04168674bfa1491e8d433933003778b274710d3a16d973cb
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE8 MOXD1 TLL1 IL6ST

1.22e-0416967458136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE8 MOXD1 TLL1 IL6ST

1.22e-0416967404c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KNTC1 GINS3 CYGB ITIH5

1.22e-04169674335619507857383c3b0b507cdf05d786ed59e585
ToppCellNasal_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SLC25A27 NRCAM MTARC2 ITIH5

1.31e-0417267404fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCellNasal_Brush-Epithelial-Ionocytes|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

SLC25A27 NRCAM MTARC2 ITIH5

1.31e-04172674dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZPBP TLL1 PNLDC1 MYB

1.34e-041736743d7c281a1a9f183a5a861d1a9c7b50d216535893
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZPBP TLL1 PNLDC1 MYB

1.34e-041736743aa90578371039f81b7c6fa873ec70f8f2bc7dfa
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 TLL1 ASIC5 GRM8

1.40e-0417567406af6629766e2054e6995e8cdb3907658fec49d3
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 MOXD1 CES1 ITIH5

1.46e-04177674b7fee75de7e96924af488a5baa2334711889ae7c
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DAB2IP MOXD1 LRRN1 ACY1

1.53e-04179674021d782134126c6f7dce6b6ea50cc54bdaa39987
ToppCell10x5'-Lung-Lymphocytic_B_plasma-Plasmablasts|Lung / Manually curated celltypes from each tissue

KNTC1 PHF19 PAK1IP1 TARBP2

1.53e-041796743fa75eec3e86fd1797eaa33362257df7f9b2a0bf
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|368C / Donor, Lineage, Cell class and subclass (all cells)

FLI1 UBE2O ZNF235 MYBL1

1.53e-0417967410c7d371937d9d93c12c8d3465430ef9e0c2ec81
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL12A1 TNN CYGB ITIH5

1.56e-04180674f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHKA2 SLC25A27 IDE TARBP2

1.59e-04181674f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCellP03-Epithelial-airway_epithelial_cell-club_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 TNN HYDIN MYB

1.59e-0418167460a91587c59029a34e7bec1255083337fe21b72a
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

CES1 C8B ITIH5 MYB

1.63e-04182674a035d45fd512bee8dac38eb387dbf39f5a8a1fed
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-6_RORB_HPCA|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CPNE8 ASIC5 GRM8 LRP1B

1.66e-04183674c7e94fe3e7669db9304b249979fef7a69c30a143
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 NRCAM LRP1B HYDIN

1.70e-041846742cbed6462fea2622871bb7e49b0df3d984239281
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

MOXD1 COL12A1 LRRN1 TNN

1.70e-041846740b336489c10e8c3c957795dd845454f03404382b
ToppCellP07-Epithelial-airway_epithelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 TNN HYDIN MYB

1.70e-04184674a5e7af3392e9d6ddad0397f1eeb6b91ed1107cc2
ToppCellP07-Epithelial-airway_epithelial_cell-club_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 TNN HYDIN MYB

1.70e-04184674ab469b9e06212462cbe2e4db8775c6778db855e6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 NRCAM LRP1B HYDIN

1.70e-04184674ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 NRCAM LRP1B HYDIN

1.70e-041846742b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLL1 CYGB ASIC5 GRM8

1.73e-0418567470de48988c1f8e0809afc8092b663aa439d8e528
ToppCellP28-Epithelial-airway_epithelial_cell-club_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 TNN HYDIN MYB

1.77e-04186674a26811481668fa25c48a064a56c198685693ad8d
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CPNE8 TLL1 GRM8 LRP1B

1.77e-041866742d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellP28-Epithelial-airway_epithelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 TNN HYDIN MYB

1.77e-04186674df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLL1 CYGB ASIC5 GRM8

1.77e-04186674d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NRCAM CYGB SEPTIN11 ITIH5

1.81e-04187674fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLL1 CYGB ASIC5 GRM8

1.81e-041876747b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLI1 CPNE8 MOXD1 TLL1

1.81e-041876746cf7be5401b81a4eeb30840fb3733d61a24af539
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLI1 CPNE8 MOXD1 TLL1

1.81e-0418767463834420db930df91b62494c9d7aaa9a25bca530
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MOXD1 NRCAM CYGB MTARC2

1.88e-04189674e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 TNN HYDIN MYB

1.88e-04189674a85099bd598a27ee64ee0664d051d89fa8d62fc9
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 MOXD1 NRCAM MTARC2

1.88e-041896742a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CES1 SEPTIN11 C8B ITIH5

1.92e-041906740eef5a8bd88ef8a25a67d9dd522d9472fa4b3d2f
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CES1 SEPTIN11 C8B ITIH5

1.92e-041906742724e8f375d8d9f5f2a77444e0491af264babac5
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MOXD1 TLL1 CYGB IL6ST

1.92e-04190674d072bb285bd34d518b958e7c9ad44739c60b359c
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_2|356C / Donor, Lineage, Cell class and subclass (all cells)

CES1 SEPTIN11 C8B ITIH5

1.92e-041906744cce4ddb79b7751d0103e10f71156977e0c34439
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE8 MOXD1 TLL1 IL6ST

1.92e-041906749b0ad888eb20acc011904d8593bc32bdef18d050
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CES1 SEPTIN11 C8B ITIH5

1.92e-0419067411fbd4e9f02750354b3aadf30edc991f8d4f8f41
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MOXD1 CYGB SEPTIN11 MTARC2

1.92e-04190674841cd55861b43578d704418b9bc0af2e8b88323a
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CES1 SEPTIN11 C8B ITIH5

1.92e-04190674148d43dd72e2e22b2cd68e17fedae6bd98b32aee
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MOXD1 NRCAM CYGB MTARC2

1.92e-04190674d60395739458d7f47a3350ade751fe3819500320
ToppCellSevere_COVID-19-Myeloid-TRAM1|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

CES1 SEPTIN11 C8B ITIH5

1.96e-04191674bd641aab36276dd952a7265ee79ba455b38d8e6b
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CES1 SEPTIN11 C8B ITIH5

1.96e-041916742b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CES1 SEPTIN11 C8B ITIH5

1.96e-0419167402e1ae144da7274171e055356d10e8d175c5347f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE8 MOXD1 TLL1 IL6ST

1.96e-0419167454bbccc554f43ba2ebdf9ea191b94c8f16081b53
ToppCellSevere_COVID-19-Myeloid-TRAM3|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

CES1 SEPTIN11 C8B ITIH5

1.96e-0419167405867b96199a46a415848409130697c810d18937
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CES1 SEPTIN11 C8B ITIH5

1.96e-041916744c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CES1 SEPTIN11 C8B ITIH5

1.96e-04191674de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 TNN HYDIN MYB

1.96e-0419167496483adb97c81208aa513782550acd8a08b63866
ToppCellrenal_papilla_nuclei-Adult_normal_reference|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MOXD1 COL12A1 NRCAM ITIH5

2.00e-041926746c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CES1 SEPTIN11 C8B ITIH5

2.00e-0419267434505a13b8a47c9286c560122fa7861b9c331a08
ToppCellCOVID-19-Myeloid-TRAM1|COVID-19 / Condition, Lineage and Cell class

CES1 SEPTIN11 C8B ITIH5

2.00e-0419267452b8578699325b0d35a2d3ba36772096130ccc0c
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CES1 SEPTIN11 C8B ITIH5

2.00e-0419267457c1410ebf90c230993e065eb78385daa3360960
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CES1 SEPTIN11 C8B ITIH5

2.00e-04192674fb0d05a2c83816794652a6e5af8713e9bb22d5db
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL12A1 CYGB SEPTIN11 GRM8

2.00e-0419267409cb5b89a164ac7444774ccc8c90323c8ea2026b
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 CPNE8 TLL1 LRP1B

2.00e-0419267481baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE8 MOXD1 TLL1 IL6ST

2.00e-04192674c157981b9a179925edcaabc0cb3b8805f0929004
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CES1 SEPTIN11 C8B ITIH5

2.04e-04193674aa679fb27f914a931e51cff7153861cde0edfd85
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

FLI1 CPNE8 TLL1 IL6ST

2.04e-0419367401c2df9206f1527c578e808978e58196c35e72f5
ToppCelldroplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 GBP6 COL12A1 CYGB

2.04e-041936742d891c00b8f0aace17d4c300b63e2341dcffa199
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 MOXD1 NRCAM MTARC2

2.08e-0419467460622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell(5)_Fibroblast-C_(Myofibroblast)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

MOXD1 CES1 CYGB ITIH5

2.08e-0419467429a72e565c19407bbd198cfbc2a78106fe830d05
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

DAB2IP COL12A1 TLL1 SEPTIN10

2.08e-04194674eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCell11.5-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

COL12A1 TNN CYGB SEPTIN11

2.08e-0419467408701590496cf85ff790e54a81493c61177e76ff
Drugmalaoxon

MOXD1 PLOD3 CES1 PLOD1

1.25e-0628664CID000015415
DrugAC1NR0UN

CES1 TOP1 TOP2B

1.29e-068663CID005282807
DrugA37536

TOP1 TOP2B MYB

3.78e-0611663CID000130471
DrugAC1L2J0B

TOP1 TOP2B

8.28e-062662CID000072943
Drugmethyl brevifolincarboxylate

TOP1 TOP2B

8.28e-062662CID005319518
Drugcyclododecatriene

GSTCD CYGB

8.28e-062662CID005367375
DrugA 62176

TOP1 TOP2B

8.28e-062662CID000132823
DrugKt 6528

TOP1 TOP2B

8.28e-062662CID000132714
Drugbutylethanolamine

PHKA1 PHKA2 PYGL

1.27e-0516663CID000249006
DrugAC1MHQTP

CYGB TOP1 TOP2B

1.84e-0518663CID003009741
Drugpolyporenic acid C

TOP1 TOP2B

2.48e-053662CID005320667
Drugpaclobutrazol

TDRD7 PLOD3 PLOD1

3.95e-0523663CID006436297
Drugrhamnazin

IDE TOP1

4.95e-054662CID005320945
Drug4-hydroxymethyl-4',5'-benzopsoralen

TOP1 TOP2B

4.95e-054662CID000147789
Drugungeremine

TOP2B MYB

4.95e-054662CID000159646
Drugmethylphenylcarbamate

TOP1 TOP2B

4.95e-054662CID000017451
Drugmitindomide

TOP1 TOP2B

4.95e-054662CID000066362
Drug2-fluoro-dATP

TOP1 TOP2B

4.95e-054662CID000126365
Drugdioxazine

TOP1 TOP2B

4.95e-054662CID011969523
Drug3-O-alpha-L-arabinopyranosyl-oleanolic acid

TOP1 TOP2B

4.95e-054662CID000124369
DrugA-74932

TOP1 TOP2B

4.95e-054662CID000132825
Drug20,29-dihydrobetulinic acid

TOP1 TOP2B

4.95e-054662CID000065319
Drugtumulosic acid

TOP1 TOP2B

4.95e-054662CID005322174
DrugNSC 380271

TOP1 TOP2B

4.95e-054662CID000342690
DrugK00051

TOP2B IL6ST MYB MYBL1

5.41e-0571664CID009549278
Drugflavanone

PHKA1 PHKA2 TOP1 MYB

7.06e-0576664CID000010251
DrugAC1Q5O3Q

CES1 TOP1 TOP2B

8.05e-0529663CID000368335
DrugNSC244427

TOP1 TOP2B

8.23e-055662CID000316448
DrugNSC 314622

TOP1 TOP2B

8.23e-055662CID000329826
Drug2-bromo-dATP

TOP1 TOP2B

8.23e-055662CID000129443
Drug3aH-benzimidazole

TOP1 TOP2B

8.23e-055662CID009548683
Drug11-deoxydaunorubicin

TOP1 TOP2B

8.23e-055662CID000158483
Drug4-demethoxy-11-deoxy-4'-epi-daunorubicin

TOP1 TOP2B

8.23e-055662CID000158476
Drugcoralyne

TOP1 TOP2B

8.23e-055662CID000023306
DrugAC1L43MI

TOP1 TOP2B

8.23e-055662CID000150081
DrugNSC622082

TOP1 TOP2B

8.23e-055662CID000494392
Drugelomotecan

TOP1 TOP2B

8.23e-055662CID000216300
Drug4-demethyl-6-O-methyldoxorubicin

TOP1 TOP2B

8.23e-055662CID000126902
Drugdehydro-histidinohydroxymerodesmosine

PLOD3 PLOD1

8.23e-055662CID003037599
Drugeupolauridine

TOP1 TOP2B

8.23e-055662CID000072486
DrugAC1L9MFU

PHKA1 PHKA2 PLOD3 PLOD1

9.50e-0582664CID000448874
Drugmannose-1-phosphate

PHKA1 PHKA2 PYGL IL6ST MYB

1.18e-04165665CID000000466
Drugintoplicine

TOP1 TOP2B

1.23e-046662CID000065954
DrugDMP 840

TOP1 TOP2B

1.23e-046662CID000060916
DrugBE-10988

TOP1 TOP2B

1.23e-046662CID000126200
Druggalbacin

TOP1 TOP2B

1.23e-046662CID000234441
Drugpyridinium formate

PLOD3 PLOD1

1.23e-046662CID013326228
DrugUCE6

TOP1 TOP2B

1.23e-046662CID000127735
Drugberberrubine

TOP1 TOP2B

1.23e-046662CID000072703
Drugsaintopin

TOP1 TOP2B

1.23e-046662CID000131350
DrugAC1L8YYB

CES1 TOP1 TOP2B

1.31e-0434663CID000435167
DrugCytosar-U

CES1 CYGB PYGL TOP1 TOP2B IL6ST MYB

1.54e-04399667CID000000596
DrugAC1Q5ZRG

FLI1 TOP1 TOP2B

1.55e-0436663CID000004526
DrugPCMB

CES1 CYGB PYGL IDE ACY1

1.68e-04178665CID000001730
DrugNBQCl

TOP1 TOP2B

1.72e-047662CID000134086
Drugnogalose

TOP1 TOP2B

1.72e-047662CID000161660
Drugnitidine

TOP1 TOP2B

1.72e-047662CID000004501
DrugtBCEU

GSTCD TOP2B

2.29e-048662CID000164059
Drug7-OMEN

TOP1 TOP2B

2.29e-048662CID000051370
Drugcoumalic acid

PLOD3 PLOD1

2.29e-048662CID000068141
Drugbatracylin

TOP1 TOP2B

2.29e-048662CID000071750
DrugAC1N0FHX

GSTCD TOP2B

2.29e-048662CID003916227
DrugHHMD

PLOD3 PLOD1

2.29e-048662CID000171068
Drughydroxyallysine

PLOD3 PLOD1

2.29e-048662CID000153008
Drug9-HME

TOP1 TOP2B

2.29e-048662CID003034753
DrugAC1L33JB

GSTCD TOP2B

2.29e-048662CID000108202
DrugCPD-7231

IDE MYB

2.29e-048662CID003085404
DrugBis-netropsin

TOP1 TOP2B

2.29e-048662CID000482856
DrugNSC-294410

TOP1 TOP2B

2.29e-048662CID000457914
DrugICI 182,780; Down 200; 1uM; MCF7; HG-U133A

PHKA2 DNAH3 PAK1IP1 IL6ST MYBL1

2.38e-04192665367_DN
Drugardisin

TOP1 TOP2B

2.94e-049662CID000417291
Drugtrimethylthiophosphate

CES1 GSTCD

2.94e-049662CID000009038
DrugIST-622

TOP1 TOP2B

2.94e-049662CID003081749
Drugorthanilic acid

GSTCD PLOD1

2.94e-049662CID000006926
Drugo-AMSA

TOP1 TOP2B

2.94e-049662CID000107747
Drugoxolinic acid

TNN TOP1 TOP2B

3.03e-0445663CID000004628
DrugT694

DDX50 TNN PYGL MYBL1

3.38e-04114664CID000000872
Drugtetrabutylammonium

GSTCD PLOD1 TOP1

3.44e-0447663CID000016027
Drugdi-fluoro

PLOD3 PLOD1 TOP1

3.67e-0448663CID000069610
Drugbenzoquinone mustard

GSTCD TOP2B

3.67e-0410662CID000150975
Drugnitracrine

ACY1 TOP1

3.67e-0410662CID000020628
Drug5-oxaproline

PLOD3 PLOD1

3.67e-0410662CID003082452
Drugtungsten oxide

MOXD1 TNN

3.67e-0410662CID000014811
DrugAC1MZ4R5

TOP1 TOP2B

3.67e-0410662CID003842392
Diseaseglycogen storage disease (is_implicated_in)

PHKA1 PHKA2 PYGL

9.31e-079673DOID:2747 (is_implicated_in)
DiseaseGlycogen phosphorylase kinase deficiency

PHKA1 PHKA2

3.04e-054672cv:C0268147
Diseasemaleate measurement, Alpha ketoglutarate measurement, fumarate measurement

GHITM GRM8

2.76e-0411672EFO_0010457, EFO_0010480, EFO_0010509
DiseaseGlycogen storage disease

PHKA1 PHKA2

6.76e-0417672cv:C0017919
DiseaseAstrocytosis

GRM8 TNR

6.76e-0417672C3887640
DiseaseGliosis

GRM8 TNR

6.76e-0417672C0017639
DiseaseCorneal astigmatism

FLI1 PHF19 TNR

7.26e-0477673EFO_1002040
DiseaseGlycogen Storage Disease

PHKA2 PYGL

1.72e-0327672C0017919
Diseaseeosinophil count

SEPTIN8 FLI1 DNAH3 C6orf89 ZPBP DYRK1A HABP2 PLOD1 GK5 MYB

1.86e-0314886710EFO_0004842

Protein segments in the cluster

PeptideGeneStartEntry
ENVVVVTIQYRLGIW

CES1

161

P23141
KGEALTVWTQIVYPE

CATSPERE

601

Q5SY80
GQVVKAYDRVEQEWV

DYRK1A

171

Q13627
HIRPKIVVVWVGTNN

PAFAH1B3

91

Q15102
ELVQRKRVGVWNVPY

PLOD3

446

O60568
VAGRQFVEKWYPVVT

DAB2IP

301

Q5VWQ8
AWGIRIYQKRTQPTV

LRP1B

456

Q9NZR2
VYGEPRELLTKVWVQ

MAGEC2

266

Q9UBF1
VPVVWKQRKIYNGEE

ITIH5

886

Q86UX2
TWIVKQPEYAVVQRG

NRCAM

546

Q92823
EIGAIEKAVIWPQYV

GHITM

106

Q9H3K2
NPEDVQEIIVWKRYS

RPS6KC1

41

Q96S38
RVPVGFYQKVWKVLQ

PHKA1

1066

P46020
VVYQIEGSKAVPWVI

CANT1

186

Q8WVQ1
VPYFSKAWQRVIQIP

KNTC1

2011

P50748
RIEQDYWQVPRKGVK

GBP6

441

Q6ZN66
QRVIELVQKYGPKRW

MYB

101

P10242
YRVETVKPGKIVWQE

NOL8

1061

Q76FK4
WGSKIAPVYQQEEIA

GRM8

311

O00222
LGWKTVKQPVYVVDV

NDUFA9

231

Q16795
DIVQGRRVGVWNVPY

PLOD1

436

Q02809
RPGVYTQVTKFLNWI

HABP2

536

Q14520
KQILNVWAYPTSVGV

HYDIN

2891

Q4G0P3
TQGYRTVQLVWKTLP

IL6ST

341

P40189
IWQITDRDYKPQVGV

COL12A1

2596

Q99715
HWQQISEIVGYEIKP

DNAH3

956

Q8TD57
SWGKIRVDAQPVKVY

DHPS

326

P49366
YKEVGWVQQVPNATT

CYGB

166

Q8WWM9
EWINQPVRVNVKREY

FLI1

56

Q01543
WSQRPAVIGDVLQVY

DDX50

371

Q9BQ39
VTIRQVKTVHQEYPW

ASIC5

281

Q9NY37
LQQVGTVAKLWIYPV

MTARC2

51

Q969Z3
SVQKVENLYPQIGWV

GK5

46

Q6ZS86
QYIQKLRAEGPQEWV

IDE

396

P14735
TTHWKVYVIARGVQP

C6orf89

321

Q6UWU4
ASWYQRIQEVPGVKT

GSTCD

316

Q8NEC7
EWGDAVQYNPAIIKV

C8B

451

P07358
PICVLYVQGVGNKEW

CPNE8

46

Q86YQ8
QRVIELVQKYGPKRW

MYBL1

96

P10243
KRTVIEQQPVLWYVF

GGT2P

181

P36268
AINRVPVGFYQRVWK

PHKA2

1076

P46019
EIYWVTPIGNKITVE

LRRN1

456

Q6UXK5
TVQGEVWKTTPYQVA

TARS3

171

A2RTX5
VLQVVQWKSEATPYR

TMEM179B

181

Q7Z7N9
THVQIYVPWILQQVG

PRSS29P

296

A6NIE9
KARQYPWGVVQVENE

SEPTIN11

251

Q9NVA2
ELPVRTWTQVYKEQV

TOP2B

946

Q02880
VELPKIYQEGWRTVF

GINS3

86

Q9BRX5
WQVVAPTQYRISVKF

TLL1

646

O43897
SVKRWPGVSEQQVYH

PNLDC1

426

Q8NA58
VIENANPWDRKVVVY

TDRD7

1056

Q8NHU6
KVEVAPGYVVTVLTW

ACY1

51

Q03154
QFIGVKEIYRPVTTW

MOXD1

491

Q6UVY6
RPGVEYTVHVWAQKG

TNN

591

Q9UQP3
YLVAWQPVVIGIVQG

RNF175

306

Q8N4F7
LQWKAPVGEVENYVI

TNR

971

Q92752
YVRVQWYPEGVKQHV

UBE2O

121

Q9C0C9
KLWQGVTPAIYRHVV

SLC25A27

86

O95847
RVTPEGKVQYLVEWE

PHF19

561

Q5T6S3
KLVRARQYPWGVVQV

SEPTIN8

251

Q92599
EWSPRGEQYVVIIQN

PAK1IP1

171

Q9NWT1
KARQYPWGVVQVENE

SEPTIN10

276

Q9P0V9
QWYGPKGKVVSVENR

ZPBP

101

Q9BS86
ELVVQKGWRLPEYTV

TARBP2

166

Q15633
RTIKEYAQNIWNVEP

PYGL

816

P06737
IPVQQSVRTGKKRYW

ZNF235

306

Q14590
WGVPIEKIYNKTQRE

TOP1

736

P11387