Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN10A SCN5A	5.55e-05	6	39	2	GO:0086006
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	PROKR1 PROKR2	2.02e-04	11	39	2	GO:0004983
GeneOntologyMolecularFunction	protein phosphatase activator activity	PPP2R5C PPP2R5D	4.96e-04	17	39	2	GO:0072542
GeneOntologyMolecularFunction	phosphatase activator activity	PPP2R5C PPP2R5D	6.91e-04	20	39	2	GO:0019211
GeneOntologyMolecularFunction	ankyrin binding	CACNA1D SCN5A	9.16e-04	23	39	2	GO:0030506
GeneOntologyMolecularFunction	dioxygenase activity	KDM6B RPE65 TMLHE	9.22e-04	98	39	3	GO:0051213
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	RPE65 TMLHE	1.08e-03	25	39	2	GO:0016702
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN10A SCN5A	1.17e-03	26	39	2	GO:0005248
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	RPE65 TMLHE	1.17e-03	26	39	2	GO:0016701
GeneOntologyMolecularFunction	monoatomic cation channel activity	SCN10A CACNA1D TRPM3 SCN5A	4.38e-03	343	39	4	GO:0005261
GeneOntologyMolecularFunction	sodium channel activity	SCN10A SCN5A	4.63e-03	52	39	2	GO:0005272
GeneOntologyMolecularFunction	neuropeptide receptor activity	PROKR1 PROKR2	4.81e-03	53	39	2	GO:0008188
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM6B TMLHE	7.15e-03	65	39	2	GO:0016706
GeneOntologyMolecularFunction	transmembrane transporter activity	SCN10A CACNA1D ATP13A5 ABCA3 TRPM3 MFSD5 SCN5A	7.20e-03	1180	39	7	GO:0022857
GeneOntologyBiologicalProcess	membrane depolarization during SA node cell action potential	CACNA1D SCN5A	3.84e-05	5	41	2	GO:0086046
GeneOntologyBiologicalProcess	cell-cell signaling involved in cardiac conduction	SCN10A CACNA1D SCN5A	4.18e-05	34	41	3	GO:0086019
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN10A CACNA1D SCN5A	4.97e-05	36	41	3	GO:0086010
GeneOntologyBiologicalProcess	bundle of His cell action potential	SCN10A SCN5A	8.04e-05	7	41	2	GO:0086043
GeneOntologyBiologicalProcess	bundle of His cell to Purkinje myocyte signaling	SCN10A SCN5A	8.04e-05	7	41	2	GO:0086028
GeneOntologyBiologicalProcess	regulation of atrial cardiac muscle cell membrane repolarization	CACNA1D SCN5A	1.07e-04	8	41	2	GO:0060372
GeneOntologyBiologicalProcess	regulation of atrial cardiac muscle cell membrane depolarization	SCN10A SCN5A	1.72e-04	10	41	2	GO:0060371
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell signaling	CACNA1D SCN5A	1.72e-04	10	41	2	GO:0086018
GeneOntologyBiologicalProcess	SA node cell action potential	CACNA1D SCN5A	1.72e-04	10	41	2	GO:0086015
GeneOntologyBiologicalProcess	atrial cardiac muscle cell membrane repolarization	CACNA1D SCN5A	2.10e-04	11	41	2	GO:0099624
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell communication	CACNA1D SCN5A	2.10e-04	11	41	2	GO:0086070
GeneOntologyBiologicalProcess	cell communication involved in cardiac conduction	SCN10A CACNA1D SCN5A	2.19e-04	59	41	3	GO:0086065
GeneOntologyBiologicalProcess	regulation of membrane depolarization	SCN10A CACNA1D SCN5A	2.42e-04	61	41	3	GO:0003254
GeneOntologyBiologicalProcess	AV node cell to bundle of His cell signaling	SCN10A SCN5A	2.51e-04	12	41	2	GO:0086027
GeneOntologyBiologicalProcess	AV node cell action potential	SCN10A SCN5A	2.51e-04	12	41	2	GO:0086016
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN10A CACNA1D SCN5A	2.54e-04	62	41	3	GO:0086002
GeneOntologyBiologicalProcess	bundle of His cell to Purkinje myocyte communication	SCN10A SCN5A	3.98e-04	15	41	2	GO:0086069
GeneOntologyBiologicalProcess	AV node cell to bundle of His cell communication	SCN10A SCN5A	3.98e-04	15	41	2	GO:0086067
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN10A CACNA1D SCN5A	6.88e-04	87	41	3	GO:0086001
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN10A CACNA1D SCN5A	8.36e-04	93	41	3	GO:0086003
GeneOntologyBiologicalProcess	membrane depolarization during cardiac muscle cell action potential	CACNA1D SCN5A	9.50e-04	23	41	2	GO:0086012
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN10A SCN5A	5.01e-04	17	41	2	GO:0001518
GeneOntologyCellularComponent	protein phosphatase type 2A complex	PPP2R5C PPP2R5D	5.63e-04	18	41	2	GO:0000159
MousePheno	sinus bradycardia	SCN10A CACNA1D SCN5A	4.29e-06	14	33	3	MP:0010637
MousePheno	increased monocyte cell number	PPP2R5C TMEM248 CTSA GPR68 CLPTM1 EPG5	1.02e-05	217	33	6	MP:0000220
MousePheno	abnormal sensory capabilities/reflexes/nociception	SCN10A DOCK4 PROKR1 CACNA1D GALC PPP2R5C PPP2R5D CTSA TRPM3 FOXJ3 RPE65 TLR3 EPG5	1.56e-05	1486	33	13	MP:0002067
MousePheno	abnormal monocyte cell number	PPP2R5C TMEM248 CTSA GPR68 CLPTM1 EPG5	5.75e-05	295	33	6	MP:0012441
MousePheno	abnormal monocyte morphology	PPP2R5C TMEM248 CTSA GPR68 CLPTM1 EPG5	6.43e-05	301	33	6	MP:0002620
MousePheno	abnormal reflex	SCN10A DOCK4 PROKR1 CACNA1D GALC PPP2R5C CTSA FOXJ3 RPE65 TLR3 EPG5	1.17e-04	1294	33	11	MP:0001961
MousePheno	abnormal sinoatrial node conduction	CACNA1D MMP7 SCN5A	1.29e-04	42	33	3	MP:0006142
MousePheno	retina outer nuclear layer degeneration	ARL3 RPE65 EPG5	2.05e-04	49	33	3	MP:0008518
MousePheno	abnormal heart electrocardiography waveform feature	SCN10A CACNA1D PPP2R5C MMP7 SFSWAP SCN5A	2.21e-04	377	33	6	MP:0010508
MousePheno	atrial fibrillation	CACNA1D SCN5A	2.40e-04	10	33	2	MP:0008543
MousePheno	abnormal impulse conducting system conduction	SCN10A CACNA1D PPP2R5C MMP7 SFSWAP SCN5A	3.04e-04	400	33	6	MP:0003137
MousePheno	abnormal PR interval	CACNA1D MMP7 SCN5A	4.74e-04	65	33	3	MP:0003901
MousePheno	fibrillation	CACNA1D SCN5A	4.83e-04	14	33	2	MP:0006109
MousePheno	decreased heart rate	SCN10A CACNA1D GALC SFSWAP SCN5A	5.30e-04	288	33	5	MP:0005333
MousePheno	abnormal heart rate	SCN10A CACNA1D GALC SFSWAP FOXJ3 SCN5A	5.37e-04	445	33	6	MP:0001629
Domain	PP2A_B56	PPP2R5C PPP2R5D	4.02e-05	5	38	2	IPR002554
Domain	B56	PPP2R5C PPP2R5D	4.02e-05	5	38	2	PF01603
Domain	Ion_trans_dom	SCN10A CACNA1D TRPM3 SCN5A	8.28e-05	114	38	4	IPR005821
Domain	Ion_trans	SCN10A CACNA1D TRPM3 SCN5A	8.28e-05	114	38	4	PF00520
Domain	NPY_rcpt	PROKR1 PROKR2	1.44e-04	9	38	2	IPR000611
Domain	Na_channel_asu	SCN10A SCN5A	1.80e-04	10	38	2	IPR001696
Domain	Na_trans_assoc	SCN10A SCN5A	1.80e-04	10	38	2	IPR010526
Domain	Na_trans_assoc	SCN10A SCN5A	1.80e-04	10	38	2	PF06512
Domain	Channel_four-helix_dom	SCN10A CACNA1D SCN5A	2.11e-04	57	38	3	IPR027359
Domain	-	SCN10A CACNA1D SCN5A	2.11e-04	57	38	3	1.20.120.350
Domain	TF_fork_head_CS_2	FOXJ2 FOXJ3	3.94e-03	46	38	2	IPR030456
Domain	TF_fork_head_CS_1	FOXJ2 FOXJ3	4.11e-03	47	38	2	IPR018122
Domain	FORK_HEAD_3	FOXJ2 FOXJ3	4.46e-03	49	38	2	PS50039
Domain	FH	FOXJ2 FOXJ3	4.46e-03	49	38	2	SM00339
Domain	FORK_HEAD_1	FOXJ2 FOXJ3	4.46e-03	49	38	2	PS00657
Domain	FORK_HEAD_2	FOXJ2 FOXJ3	4.46e-03	49	38	2	PS00658
Domain	Forkhead	FOXJ2 FOXJ3	4.46e-03	49	38	2	PF00250
Domain	Fork_head_dom	FOXJ2 FOXJ3	4.46e-03	49	38	2	IPR001766
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	PROKR1 PROKR2	1.30e-04	8	31	2	M47642
Pathway	KEGG_MEDICUS_REFERENCE_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	PROKR1 PROKR2	1.67e-04	9	31	2	M47641
Pathway	REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS	PPP2R5C PPP2R5D	4.83e-04	15	31	2	M27407
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE	PPP2R5C PPP2R5D	5.51e-04	16	31	2	M47870
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2R5C PPP2R5D	6.24e-04	17	31	2	MM15096
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2R5C PPP2R5D	6.24e-04	17	31	2	M27083
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2R5C PPP2R5D	6.24e-04	17	31	2	M919
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2R5C PPP2R5D	7.01e-04	18	31	2	MM14759
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	PPP2R5C PPP2R5D	7.82e-04	19	31	2	M47525
Pathway	KEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING	PPP2R5C PPP2R5D	8.68e-04	20	31	2	M47876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2R5C PPP2R5D	9.58e-04	21	31	2	M5876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2R5C PPP2R5D	9.58e-04	21	31	2	MM14996
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY	PPP2R5C PPP2R5D	1.05e-03	22	31	2	M47919
Pathway	KEGG_MEDICUS_REFERENCE_GPI_ANCHOR_BIOSYNTHESIS	PIGV PGAP1	1.25e-03	24	31	2	M47625
Pathway	KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS	PIGV PGAP1	1.36e-03	25	31	2	M13265
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	PPP2R5C PPP2R5D	2.09e-03	31	31	2	M27400
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	PPP2R5C PPP2R5D	2.09e-03	31	31	2	MM15154
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN10A SCN5A	2.09e-03	31	31	2	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN10A SCN5A	2.23e-03	32	31	2	M27455
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	GALC CTSA	2.51e-03	34	31	2	MM17076
Pathway	REACTOME_SIGNALING_BY_WNT_IN_CANCER	PPP2R5C PPP2R5D	2.51e-03	34	31	2	M27405
Pathway	REACTOME_RAF_ACTIVATION	PPP2R5C PPP2R5D	2.51e-03	34	31	2	M27556
Pathway	WP_GLYCOGEN_METABOLISM	PPP2R5C PPP2R5D	2.51e-03	34	31	2	MM15985
Pathway	WP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME	PPP2R5C PPP2R5D	2.51e-03	34	31	2	M42555
Pathway	REACTOME_RAF_ACTIVATION	PPP2R5C PPP2R5D	2.66e-03	35	31	2	MM15271
Pubmed	A common genetic variant within SCN10A modulates cardiac SCN5A expression.	SCN10A SCN5A	1.36e-06	2	41	2	24642470
Pubmed	Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.	PROKR1 PROKR2	1.36e-06	2	41	2	26984842
Pubmed	Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation.	PROKR1 PROKR2	1.36e-06	2	41	2	16901473
Pubmed	Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a.	CACNA1D SCN5A	1.36e-06	2	41	2	15932895
Pubmed	Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.	PROKR1 PROKR2	1.36e-06	2	41	2	22132188
Pubmed	Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.	PROKR1 PROKR2	1.36e-06	2	41	2	11886876
Pubmed	Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.	SCN10A SCN5A	1.36e-06	2	41	2	15047701
Pubmed	Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.	SCN10A SCN5A	1.36e-06	2	41	2	24998131
Pubmed	Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy.	PROKR1 PROKR2	1.36e-06	2	41	2	23687280
Pubmed	From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.	SCN10A SCN5A	1.36e-06	2	41	2	24360055
Pubmed	Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.	SCN10A SCN5A	1.36e-06	2	41	2	31292628
Pubmed	Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.	SCN10A SCN5A	1.36e-06	2	41	2	32330377
Pubmed	Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.	PROKR1 PROKR2	4.06e-06	3	41	2	20023120
Pubmed	The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.	PROKR1 PROKR2	4.06e-06	3	41	2	19667192
Pubmed	Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss.	PROKR1 PROKR2	4.06e-06	3	41	2	20847187
Pubmed	Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.	PROKR1 PROKR2	4.06e-06	3	41	2	33811988
Pubmed	Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.	PROKR1 PROKR2	4.06e-06	3	41	2	17531315
Pubmed	Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia.	CACNA1D SCN5A	4.06e-06	3	41	2	32555258
Pubmed	Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms.	PROKR1 PROKR2	4.06e-06	3	41	2	25064403
Pubmed	Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.	PPP2R5C PPP2R5D	4.06e-06	3	41	2	15051958
Pubmed	Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.	PPP2R5C PPP2R5D	4.06e-06	3	41	2	25972378
Pubmed	High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.	SCN10A SCN5A	4.06e-06	3	41	2	25998140
Pubmed	Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors.	PROKR1 PROKR2	4.06e-06	3	41	2	22138749
Pubmed	Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.	PROKR1 PROKR2	4.06e-06	3	41	2	26730729
Pubmed	Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.	PROKR1 PROKR2	8.12e-06	4	41	2	15126578
Pubmed	The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.	PROKR1 PROKR2	8.12e-06	4	41	2	12604792
Pubmed	Genome-wide association studies of the PR interval in African Americans.	SCN10A SCN5A	8.12e-06	4	41	2	21347284
Pubmed	Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.	PPP2R5C PPP2R5D	8.12e-06	4	41	2	18056802
Pubmed	Abnormal Pain Sensation in Mice Lacking the Prokineticin Receptor PKR2: Interaction of PKR2 with Transient Receptor Potential TRPV1 and TRPA1.	PROKR1 PROKR2	8.12e-06	4	41	2	31883821
Pubmed	Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.	PROKR1 PROKR2	8.12e-06	4	41	2	26192875
Pubmed	Molecular cloning and characterization of prokineticin receptors.	PROKR1 PROKR2	8.12e-06	4	41	2	12427552
Pubmed	The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy.	PROKR1 PROKR2	8.12e-06	4	41	2	16763065
Pubmed	Prokineticins in central and peripheral control of human reproduction.	PROKR1 PROKR2	8.12e-06	4	41	2	26574895
Pubmed	Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice.	PPP2R5C PPP2R5D	1.35e-05	5	41	2	15095873
Pubmed	Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.	PPP2R5C PPP2R5D	1.35e-05	5	41	2	8812429
Pubmed	Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.	SCN10A SCN5A	1.35e-05	5	41	2	22706305
Pubmed	Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.	PROKR1 PROKR2	1.35e-05	5	41	2	21858136
Pubmed	Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.	SCN10A SCN5A	1.35e-05	5	41	2	23463857
Pubmed	Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis.	PROKR1 PROKR2	1.35e-05	5	41	2	12746324
Pubmed	Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.	SCN10A SCN5A	1.35e-05	5	41	2	23872634
Pubmed	A PP1-PP2A phosphatase relay controls mitotic progression.	PPP2R5C PPP2R5D	1.35e-05	5	41	2	25487150
Pubmed	Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells.	PROKR1 PROKR2	2.03e-05	6	41	2	17324478
Pubmed	Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.	SCN10A SCN5A	2.84e-05	7	41	2	23139255
Pubmed	The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.	PPP2R5C PPP2R5D	2.84e-05	7	41	2	8703017
Pubmed	Identification of a new family of protein phosphatase 2A regulatory subunits.	PPP2R5C PPP2R5D	2.84e-05	7	41	2	7592815
Pubmed	Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.	DOCK4 PROKR2 ASNS	3.82e-05	55	41	3	19884258
Pubmed	De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.	PPP2R5C PPP2R5D	4.86e-05	9	41	2	30595372
Pubmed	Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.	PROKR1 PROKR2	4.86e-05	9	41	2	16537498
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN10A SCN5A	4.86e-05	9	41	2	16382098
Pubmed	Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.	PPP2R5C PPP2R5D	4.86e-05	9	41	2	16239230
Pubmed	Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression.	PPP2R5C PPP2R5D	4.86e-05	9	41	2	23345399
Pubmed	Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.	SCN10A CACNA1D	6.07e-05	10	41	2	25055868
Pubmed	Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.	PPP2R5C PPP2R5D	8.88e-05	12	41	2	15380617
Pubmed	Genome-wide association study of PR interval.	SCN10A SCN5A	8.88e-05	12	41	2	20062060
Pubmed	Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.	PPP2R5C PPP2R5D	8.88e-05	12	41	2	16541024
Pubmed	Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.	PPP2R5C PPP2R5D	1.05e-04	13	41	2	18971272
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN10A SCN5A	1.05e-04	13	41	2	15123669
Pubmed	PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.	PPP2R5C PPP2R5D	1.05e-04	13	41	2	21072166
Pubmed	Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.	PPP2R5C PPP2R5D	1.22e-04	14	41	2	9013886
Pubmed	Several common variants modulate heart rate, PR interval and QRS duration.	SCN10A SCN5A	1.22e-04	14	41	2	20062063
Pubmed	Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.	PPP2R5C PPP2R5D	1.22e-04	14	41	2	9400615
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP2R5C PPP2R5D	1.22e-04	14	41	2	16048649
Pubmed	Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.	PROKR1 PROKR2	1.41e-04	15	41	2	12024206
Pubmed	Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.	SCN10A SCN5A	1.61e-04	16	41	2	25035420
Pubmed	Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.	SCN10A SCN5A	1.82e-04	17	41	2	21076409
Pubmed	Genetic determinants of P wave duration and PR segment.	SCN10A SCN5A	1.82e-04	17	41	2	24850809
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP2R5C PPP2R5D	1.82e-04	17	41	2	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP2R5C PPP2R5D	1.82e-04	17	41	2	21351466
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	ATP13A5 MFSD5 NBEAL2 PGAP1 TLR3	2.00e-04	460	41	5	20562862
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	PPP2R5D KDM6B	2.05e-04	18	41	2	25363768
Pubmed	Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.	PPP2R5C PPP2R5D	2.05e-04	18	41	2	23287597
Pubmed	Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.	CACNA1D CHGB	2.05e-04	18	41	2	33087486
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN10A SCN5A	2.05e-04	18	41	2	31666509
Pubmed	Shugoshin collaborates with protein phosphatase 2A to protect cohesin.	PPP2R5C PPP2R5D	2.29e-04	19	41	2	16541025
Pubmed	Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.	SCN10A TRPM3	2.54e-04	20	41	2	33789102
Pubmed	GATA6 is a regulator of sinus node development and heart rhythm.	CACNA1D SCN5A	2.54e-04	20	41	2	33443158
Pubmed	Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.	ABCA3 KDM6B	3.09e-04	22	41	2	25079229
Pubmed	Brugada Syndrome	SCN10A SCN5A	3.68e-04	24	41	2	20301690
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PCNX1 PPP2R5C KDM6B FOXJ3 NBEAL2	3.81e-04	529	41	5	14621295
Pubmed	MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors.	TRPM3 RPE65	4.00e-04	25	41	2	26062936
Pubmed	HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.	PPP2R5C PPP2R5D	4.33e-04	26	41	2	11531413
Pubmed	Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus.	CHGB TRPM3	5.39e-04	29	41	2	28344592
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	SCN10A SCN5A	5.78e-04	30	41	2	39366945
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	SCN10A CACNA1D SCN5A	5.96e-04	139	41	3	16985003
Pubmed	The tumor suppressor PP2A Abeta regulates the RalA GTPase.	PPP2R5C PPP2R5D	6.58e-04	32	41	2	17540176
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	FOXJ2 FOXJ3	6.58e-04	32	41	2	27739607
Pubmed	Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.	CTSA CLPTM1	9.28e-04	38	41	2	16263699
Interaction	SCN10A interactions	SCN10A CACNA1D SCN5A	1.01e-06	11	38	3	int:SCN10A
Interaction	SCN11A interactions	SCN10A CACNA1D SCN5A	2.77e-06	15	38	3	int:SCN11A
Interaction	CACNA1D interactions	SCN10A CACNA1D SCN5A	1.22e-05	24	38	3	int:CACNA1D
Interaction	SCN1A interactions	SCN10A CACNA1D SCN5A	2.18e-05	29	38	3	int:SCN1A
Interaction	SCN5A interactions	SCN10A CACNA1D SCN5A	9.47e-05	47	38	3	int:SCN5A
Cytoband	14q31	GALC GPR68	2.79e-05	9	41	2	14q31
GeneFamily	Prokineticin receptors	PROKR1 PROKR2	1.99e-06	2	26	2	216
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN10A SCN5A	7.11e-05	9	26	2	1203
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R5C PPP2R5D	2.06e-04	15	26	2	696
GeneFamily	Forkhead boxes	FOXJ2 FOXJ3	1.73e-03	43	26	2	508
GeneFamily	T-cell receptor alpha locus at 14q11.2	TRAV3 TRAV38-1	1.22e-02	117	26	2	371
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FOXJ2 GALC APOBEC2 EPG5	1.75e-05	169	41	4	01a24a8817628125bd004b2be68ffa62c7111f6e
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PIGV FOXJ3 GPR68 ASNS	1.96e-05	174	41	4	c0204a0d0a979a489e8d30dc5396e99da14c119c
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D PCNX1 TRPM3 APOBEC2	2.14e-05	178	41	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PROKR2 CHN2 TRPM3 SCN5A	2.24e-05	180	41	4	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	Neuronal-Excitatory-eG(DAPK2)-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PROKR2 CHN2 TRPM3 SCN5A	3.37e-05	200	41	4	7cea58e2691564e653cc972bf5aaff2df1f2666e
ToppCell	Neuronal-Excitatory-eG(DAPK2)--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PROKR2 CHN2 TRPM3 SCN5A	3.37e-05	200	41	4	193c42c31a366a60d80c4c1fc6a1592a5b01a3ad
ToppCell	Neuronal-Excitatory-eG(DAPK2)---\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PROKR2 CHN2 TRPM3 SCN5A	3.37e-05	200	41	4	7c780e995a5fc3793080da61b6bf7a12880e9df8
ToppCell	Neuronal-Excitatory-eG(DAPK2)----L4-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PROKR2 CHN2 TRPM3 SCN5A	3.37e-05	200	41	4	d0b31dc5eedc0635c0d7ceabaa6202386cf2a4a4
ToppCell	Neuronal-Excitatory-eG(DAPK2)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PROKR2 CHN2 TRPM3 SCN5A	3.37e-05	200	41	4	8444ae3c10b1152dec67ca812e6c417cc3b9cf89
Drug	Hexylcaine	SCN10A SCN5A	2.86e-06	2	39	2	DB00473
Drug	Dibucaine	SCN10A SCN5A	8.57e-06	3	39	2	DB00527
Drug	Dipivefrin hydrochloride [64019-93-8]; Up 200; 10.4uM; HL60; HG-U133A	DOCK4 PCNX1 EDC4 CHN2 CLPTM1	1.35e-05	180	39	5	1752_UP
Drug	Lidocaine	SCN10A SCN5A	1.71e-05	4	39	2	DB00281
Drug	Procaine hydrochloride [51-05-8]; Down 200; 14.6uM; HL60; HT_HG-U133A	DOCK4 PCNX1 SFSWAP NBEAL2 PGAP1	2.14e-05	198	39	5	1838_DN
Drug	Calycanthine [595-05-1]; Up 200; 11.6uM; HL60; HG-U133A	SCN10A GALC PPP2R5D PIGV CHN2	2.19e-05	199	39	5	1771_UP
Disease	Auriculo-Ventricular Dissociation	SCN10A CACNA1D	1.02e-05	4	39	2	C0004331
Disease	Heart Block	SCN10A CACNA1D	1.02e-05	4	39	2	C0018794
Disease	Brugada ECG Pattern	SCN10A SCN5A	1.02e-05	4	39	2	C1721096
Disease	Sick Sinus Syndrome	CACNA1D SCN5A	2.54e-05	6	39	2	C0037052
Disease	electrocardiography, PR interval	SCN10A SCN5A	3.56e-05	7	39	2	EFO_0004327, EFO_0004462
Disease	supraventricular ectopy	SCN10A SCN5A	6.09e-05	9	39	2	EFO_0009277
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN10A SCN5A	7.61e-05	10	39	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN10A SCN5A	7.61e-05	10	39	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN10A SCN5A	1.11e-04	12	39	2	DOID:0060170 (implicated_via_orthology)
Disease	Brugada Syndrome 1	SCN10A SCN5A	1.32e-04	13	39	2	C4551804
Disease	T wave morphology measurement	SCN10A SCN5A	1.53e-04	14	39	2	EFO_0008398
Disease	Sinus Node Dysfunction (disorder)	SCN10A CACNA1D	1.77e-04	15	39	2	C0428908
Disease	P wave duration	SCN10A SCN5A	1.77e-04	15	39	2	EFO_0005094
Disease	Romano-Ward Syndrome	SCN10A SCN5A	2.02e-04	16	39	2	C0035828
Disease	Brugada syndrome	SCN10A SCN5A	2.87e-04	19	39	2	MONDO_0015263
Disease	R-warfarin measurement	SCN10A DOCK4 CHGB CHN2	4.08e-04	265	39	4	EFO_0803324
Disease	Brugada Syndrome (disorder)	SCN10A SCN5A	4.61e-04	24	39	2	C1142166
Disease	PR interval	SCN10A DOCK4 CACNA1D TRPM3 SCN5A	4.68e-04	495	39	5	EFO_0004462
Disease	cardiovascular age measurement	SCN10A SCN5A	6.76e-04	29	39	2	EFO_0803380
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	ATP13A5 EPG5	7.23e-04	30	39	2	DOID:332 (implicated_via_orthology)
Disease	heart function measurement	SCN10A SCN5A	9.30e-04	34	39	2	EFO_0004311
Disease	resting heart rate	SCN10A CACNA1D SCN5A	1.01e-03	149	39	3	EFO_0004351

Protein segments in the cluster

Peptide	Gene	Start	Entry
KYPYLWLCYNGEIYN	ASNS	66	P08243
KHWTYLLLYQFPDQY	EPG5	1816	Q9HCE0
AFLYVKQQPWYCEVY	ATP13A5	991	Q4VNC0
PYWKNYFENTDILIY	ARL3	76	P36405
KYNIQYQENFYAWSA	ABCA3	1286	Q99758
FQVAERALYYWNNEY	PPP2R5D	416	Q14738
QVAERALYYWNNEYI	PPP2R5C	341	Q13362
AFQPWEDIQENFLYY	APOBEC2	201	Q9Y235
YDWEQKYYYGNLIAV	EDC4	126	Q6P2E9
SYERLWPIYNYQVFN	ACP7	336	Q6ZNF0
QWEQAQDYLKRFYLY	MMP7	31	P09237
YQYQLALERYEWNEV	KDM6B	1491	O15054
LYKLQFVYTYIAPWQ	PCNX1	1451	Q96RV3
EIYRWICDNFPYYKN	FOXJ2	91	Q9P0K8
EYNPYSWNLIANVLY	CTSA	111	P10619
YQPPIWKSYLYQLQQ	CHN2	21	P52757
NENFDYKIWDSYFYL	DOCK4	996	Q8N1I0
DRWYSEIKNYNFQQP	GLIPR2	81	Q9H4G4
LSEIYQWICDNFPYY	FOXJ3	101	Q9UPW0
FDWPYVNLQLTAYYV	GALC	161	P54803
TLNEKNFFPEYNYDW	CHGB	556	P05060
KNPYQYKFWYVVNSS	CACNA1D	1191	Q01668
DWLQAPYLYKLYQHY	MFSD5	56	Q6N075
YPIQAWQRAINYYRF	GPR68	176	Q15743
FVYNYLYLANLRENW	RPE65	336	Q16518
FEFLQPWHQYNAYYE	SFSWAP	486	Q12872
PWHQYNAYYEFKKQF	SFSWAP	491	Q12872
NTKYAQDYNPFWCYK	TMEM248	226	Q9NWD8
WLLYYAQKDLGYLQQ	NBEAL2	11	Q6ZNJ1
LDPYYYFQQGWNIFD	SCN5A	771	Q14524
EQPQWEYNLYMYIYF	SCN5A	1436	Q14524
YWLKNLRYYFKLNPD	PGAP1	836	Q75T13
YPIIYFNDYWNLQKD	CLPTM1	276	O96005
FNDYWNLQKDYYPIN	CLPTM1	281	O96005
WPVDQQLYYKSYFLF	PROKR1	221	Q8TCW9
YIQDVYWNVGFLKYY	PIGV	306	Q9NUD9
WLPQLEYFFLEYNNI	TLR3	296	O15455
IIAFDPYYYFQKKWN	SCN10A	716	Q9Y5Y9
PYYYFQKKWNIFDCI	SCN10A	721	Q9Y5Y9
YNAPIVKFWFYTLAY	TRPM3	891	Q9HCF6
IWPVDQQLYYKSYFL	PROKR2	211	Q8NFJ6
YLFWYVQYPNRGLQF	TRAV3	51	A0A0B4J244
IYPWNKELYLIRYNN	TMLHE	321	Q9NVH6
DYNLYRKFWSLQDYF	THOC1	231	Q96FV9
DTSENNYYLFWYKQP	TRAV38-1	46	A0A0B4J264