Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionN-acylsphingosine amidohydrolase activity

ASAH2 ASAH2B

4.87e-057312GO:0017040
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

FUCA1 ASAH2 ASAH2B

5.39e-04103313GO:0004553
GeneOntologyMolecularFunctionsialic acid binding

SIGLEC7 FCN1

6.84e-0425312GO:0033691
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

FUCA1 ASAH2 ASAH2B

1.42e-03144313GO:0016798
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

MBLAC2 ASAH2 ASAH2B

1.48e-03146313GO:0016810
GeneOntologyMolecularFunctionzinc ion binding

TRIM43B TRHDE TRIM43 TRIM64C ASAH2 ASAH2B

2.19e-03891316GO:0008270
DomainCeramidse_alk_C

ASAH2 ASAH2B

2.33e-062292PF17048
DomainCeramidase_alk

ASAH2 ASAH2B

2.33e-062292IPR006823
DomainNEUT/ALK_ceramidase_C

ASAH2 ASAH2B

2.33e-062292IPR031331
DomainButyrophylin

TRIM43B TRIM43 BTN2A2

1.72e-0470293IPR003879
DomainSPRY

TRIM43B TRIM43 BTN2A2

3.27e-0487293SM00449
DomainFibrinogen_CS

FCN1 TNXB

3.92e-0419292IPR020837
DomainSPRY

TRIM43B TRIM43 BTN2A2

4.10e-0494293PF00622
DomainSPRY_dom

TRIM43B TRIM43 BTN2A2

4.10e-0494293IPR003877
DomainB30.2/SPRY

TRIM43B TRIM43 BTN2A2

4.23e-0495293IPR001870
DomainB302_SPRY

TRIM43B TRIM43 BTN2A2

4.23e-0495293PS50188
Domain-

FCN1 TNXB

6.29e-04242924.10.530.10
DomainFibrinogen_a/b/g_C_2

FCN1 TNXB

6.29e-0424292IPR014715
DomainC2H2_Znf_fam

ZSCAN29 ZKSCAN2

6.29e-0424292IPR027775
DomainFibrinogen_C

FCN1 TNXB

7.98e-0427292PF00147
DomainFBG

FCN1 TNXB

9.21e-0429292SM00186
Domain-

FCN1 TNXB

9.86e-04302923.90.215.10
DomainFibrinogen_a/b/g_C_1

FCN1 TNXB

9.86e-0430292IPR014716
DomainFibrinogen_a/b/g_C_dom

FCN1 TNXB

1.12e-0332292IPR002181
DomainFIBRINOGEN_C_2

FCN1 TNXB

1.12e-0332292PS51406
DomainFIBRINOGEN_C_1

FCN1 TNXB

1.12e-0332292PS00514
DomainC2-set_2

BTN2A2 SIGLEC7

1.84e-0341292PF08205
DomainCD80_C2-set

BTN2A2 SIGLEC7

1.84e-0341292IPR013162
DomainSCAN

ZSCAN29 ZKSCAN2

3.40e-0356292SM00431
DomainSCAN_BOX

ZSCAN29 ZKSCAN2

3.65e-0358292PS50804
DomainSCAN

ZSCAN29 ZKSCAN2

3.65e-0358292PF02023
DomainSCAN_dom

ZSCAN29 ZKSCAN2

3.65e-0358292IPR003309
DomainRetrov_capsid_C

ZSCAN29 ZKSCAN2

3.77e-0359292IPR008916
DomainConA-like_dom

TRIM43B TRIM43 BTN2A2

4.64e-03219293IPR013320
DomainBBOX

TRIM43B TRIM43

5.12e-0369292SM00336
Domain-

TRIM43B TRIM43

5.41e-03712924.10.45.10
DomainZF_BBOX

TRIM43B TRIM43

6.82e-0380292PS50119
DomainZnf_B-box

TRIM43B TRIM43

6.99e-0381292IPR000315
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM43B TRIM43 TRIM64C

3.19e-071532319703589
Pubmed

Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.

ASAH2 ASAH2B

8.20e-07232210652340
Pubmed

Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.

ASAH2 ASAH2B

8.20e-07232216380386
Pubmed

Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.

ASAH2 ASAH2B

8.20e-07232214557071
Pubmed

Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury.

ASAH2 ASAH2B

8.20e-07232235151662
Pubmed

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.

ASAH2 ASAH2B

8.20e-07232222940715
Pubmed

Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.

ASAH2 ASAH2B

8.20e-07232224659784
Pubmed

A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.

ASAH2 ASAH2B

8.20e-07232217334805
Pubmed

Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.

ASAH2 ASAH2B

8.20e-07232226747710
Pubmed

Genomic structure and promoter analysis of the mouse neutral ceramidase gene.

ASAH2 ASAH2B

8.20e-07232212435403
Pubmed

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases.

ASAH2 ASAH2B

8.20e-07232210753931
Pubmed

Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population.

ASAH2 ASAH2B

8.20e-07232237944753
Pubmed

Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney.

ASAH2 ASAH2B

8.20e-07232211328816
Pubmed

Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.

ASAH2 ASAH2B

8.20e-07232235354041
Pubmed

Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.

ASAH2 ASAH2B

8.20e-07232221613224
Pubmed

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.

ASAH2 ASAH2B

8.20e-07232216126722
Pubmed

Role of neutral ceramidase in colon cancer.

ASAH2 ASAH2B

8.20e-07232227609772
Pubmed

Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.

ASAH2 ASAH2B

8.20e-07232219345744
Pubmed

Lactosylceramide contributes to mitochondrial dysfunction in diabetes.

ASAH2 ASAH2B

8.20e-07232226900161
Pubmed

Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.

ASAH2 ASAH2B

2.46e-06332218955860
Pubmed

The molecular circuitry regulating the switch between iron deficiency and overload in mice.

ASAH2 ASAH2B

2.46e-06332216418170
Pubmed

Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1.

ASAH2 ASAH2B

2.46e-06332212921776
Pubmed

Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.

ASAH2 ASAH2B

2.46e-06332238302493
Pubmed

Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter.

ASAH2 ASAH2B

2.46e-06332220803549
Pubmed

Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.

ASAH2 ASAH2B

4.92e-06432233547170
Pubmed

Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells.

ASAH2 ASAH2B

4.92e-06432211591392
Pubmed

Lineage-specific biology revealed by a finished genome assembly of the mouse.

TRIM43B TRIM43 TRIM64C

1.80e-055532319468303
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

TBXT LRP8

1.70e-042132221337463
Pubmed

Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.

TBXT LRP8

2.43e-042532215857914
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

TRIM43B NIPSNAP2 TRIM43 COQ3 CLCN3 ATP2A1 ANAPC7

2.81e-04144232735575683
Pubmed

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.

ASAH2 ASAH2B

2.84e-042732223096701
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

GEMIN5 TUBA3E ATP2A1

8.46e-0420232324639526
Cytoband16p12.1

ZKSCAN2 ATP2A1

1.40e-042532216p12.1
Cytoband2q11.1

TRIM43B TRIM43

1.76e-04283222q11.1
Cytoband1p34

FUCA1 LRP8

2.30e-04323221p34
CytobandEnsembl 112 genes in cytogenetic band chr12p12

ETNK1 KCNJ8

2.84e-03113322chr12p12
CytobandEnsembl 112 genes in cytogenetic band chr2q11

TRIM43B TRIM43

5.13e-03153322chr2q11
CytobandEnsembl 112 genes in cytogenetic band chr10q11

ASAH2 ASAH2B

7.63e-03188322chr10q11
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM43B TRIM43 TRIM64C

2.01e-049522359
GeneFamilyFibrinogen C domain containing

FCN1 TNXB

4.17e-0425222554
GeneFamilyRing finger proteins

TRIM43B TRIM43 TRIM64C

4.33e-0327522358
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

ANAPC7 TTC38

8.53e-03115222769
GeneFamilyAdenosine receptors|V-set domain containing

BTN2A2 SIGLEC7

1.66e-02163222590
ToppCellremission-unassigned|World / disease stage, cell group and cell class

SMG9 ETNK1 CXCR6 ASAH2

4.52e-06155324d81bec894381e3e2d6249a567e8108b8423e5c54
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRIM43B TRIM43 TBXT TRIM64C

8.16e-06180324a499548391e6833b78f6e920f8e32a755814a9da
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Thalamus / BrainAtlas - Mouse McCarroll V32

CXCR6 EPHX3 KCNJ8

2.89e-05833234017af9a4804a06d0f2cd0f285ebf1b582b751de
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Car4_(Mural.Rgs5Acta2.Car4)|Thalamus / BrainAtlas - Mouse McCarroll V32

CXCR6 EPHX3 KCNJ8

2.89e-058332359fce941d45f9763a8584f3fd5b7c0738de9f592
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Car4_(Mural.Rgs5Acta2.Car4)-|Thalamus / BrainAtlas - Mouse McCarroll V32

CXCR6 EPHX3 KCNJ8

2.89e-0583323ebabce70dc01fdeda7fccebc2c4a0b686cda580f
Diseasemajor depressive disorder, COVID-19

ZKSCAN2 CXCR6

2.99e-0426292MONDO_0002009, MONDO_0100096
Diseaserheumatoid arthritis, COVID-19

ZKSCAN2 TNXB

1.81e-0364292EFO_0000685, MONDO_0100096
Diseaseautism spectrum disorder, schizophrenia

BTN2A2 CLCN3 TNXB

3.98e-03327293EFO_0003756, MONDO_0005090
Diseasecerebrospinal fluid biomarker measurement

SIGLEC7 ASAH2

4.02e-0396292EFO_0006794
Diseaserisk-taking behaviour

TRHDE ATP2A1 TNXB LRP8

6.33e-03764294EFO_0008579

Protein segments in the cluster

PeptideGeneStartEntry
WEDVWLKEGFAHYFE

TRHDE

456

Q9UKU6
FWAYAGIHEWVFGQV

CXCR6

86

O00574
NDASWETRFYWHKGL

ASAH2B

96

P0C7U1
LALAHKWWDEQGVYA

COQ3

101

Q9NZJ6
AATVGAAAWWFLYAE

ATP2A1

846

O14983
AAWHKHGWEELVYYT

NIPSNAP2

251

O75323
WLSVWIKAYAFVHTG

ANAPC7

201

Q9UJX3
WWLVAFAHGDIYAYM

KCNJ8

91

Q15842
NDASWETRFYWHKGL

ASAH2

711

Q9NR71
AWFDEAKFGVFIHWG

FUCA1

51

P04066
AEKFQGAWWYADCHA

FCN1

271

O00602
AHDWGALLAWHFSIY

EPHX3

171

Q9H6B9
WYAHKSLGDGIFWIQ

MBLAC2

6

Q68D91
SHFFWGLWALIQAKY

ETNK1

406

Q9HBU6
KHGALFWDLAQLFWD

FAM237A

86

A0A1B0GTK4
VLGWESFASGKHYWE

BTN2A2

371

Q8WVV5
GLAVDWVHKHIYWTD

LRP8

501

Q14114
AWGARVFSFGKHYWE

TRIM43

326

Q96BQ3
TEKNWFHYAARIWDG

SMG9

491

Q9H0W8
VHGYWFRAGNDISWK

SIGLEC7

61

Q9Y286
GWAHLRWGVFDEYNV

CLCA3P

156

Q9Y6N3
YHHDWFIFKEWCEVG

CLCN3

551

P51790
QGVSWYHWKGFEFSV

TNXB

4211

P22105
AGYHVWLWAVEAFAK

GEMIN5

956

Q8TEQ6
IAFLWKHWDALFSYV

TMCC1

631

O94876
AADNHRWKYVNGEWV

TBXT

96

O15178
WHWALYLIEKGEYEA

TTC38

256

Q5R3I4
WGLEDEKIAGVHWSY

ZKSCAN2

331

Q63HK3
AWGARVFSFGKHYWE

TRIM43B

326

A6NCK2
DLMYAKWAFVHWYVG

TUBA3E

396

Q6PEY2
WSFEDEKVAGVHWGY

ZSCAN29

236

Q8IWY8
WCAQAFTSGKHYWEV

TRIM64C

331

A6NLI5