Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51A4 OR51A2 MCHR2 GPR87 ADGRV1 OR52P1 EDNRB OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 ACKR3 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 TAAR1 OR56A1 NMBR ADGRF1	3.32e-10	884	128	25	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR51A4 OR51A2 OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 OR52E5 OR2D2 OR56A1	1.72e-08	431	128	16	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51A4 OR51A2 MCHR2 GPR87 ADGRV1 OR52P1 EDNRB OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P P2RX7 OR2AT4 ACKR3 OR52N2 TLR5 OR52E1 TAS1R2 OR52E5 OR2D2 ROS1 TAAR1 OR56A1 NMBR ADGRF1	2.58e-08	1353	128	28	GO:0004888
GeneOntologyMolecularFunction	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	RPN1 STT3A STT3B	2.55e-06	5	128	3	GO:0004579
GeneOntologyMolecularFunction	oligosaccharyl transferase activity	RPN1 STT3A STT3B	2.55e-06	5	128	3	GO:0004576
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	PLSCR5 CLPTM1L ATP11B ATP11C TMEM41B	1.86e-05	51	128	5	GO:0140303
GeneOntologyMolecularFunction	phospholipid transporter activity	PLSCR5 CLPTM1L ATP11B ATP11C TMEM41B	1.13e-04	74	128	5	GO:0005548
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	2.43e-04	4	128	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	2.43e-04	4	128	2	GO:0045703
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	2.43e-04	4	128	2	GO:0047718
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	2.43e-04	4	128	2	GO:0047743
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	4.03e-04	5	128	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	4.03e-04	5	128	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	4.03e-04	5	128	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	4.03e-04	5	128	2	GO:0047006
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	4.03e-04	5	128	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	4.03e-04	5	128	2	GO:0047086
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	4.03e-04	5	128	2	GO:0047787
GeneOntologyMolecularFunction	phospholipid scramblase activity	PLSCR5 CLPTM1L TMEM41B	4.15e-04	23	128	3	GO:0017128
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C2	6.01e-04	6	128	2	GO:0045550
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	8.38e-04	7	128	2	GO:0072582
GeneOntologyMolecularFunction	phosphatidylethanolamine flippase activity	ATP11B ATP11C	8.38e-04	7	128	2	GO:0090555
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C2	1.11e-03	8	128	2	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C1 AKR1C2	1.11e-03	8	128	2	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C2	1.11e-03	8	128	2	GO:0035671
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C2	1.43e-03	9	128	2	GO:0047044
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP11B ATP11C	1.43e-03	9	128	2	GO:0090556
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C2	1.43e-03	9	128	2	GO:0070401
GeneOntologyMolecularFunction	lipid transporter activity	PLSCR5 ABCA13 CLPTM1L ATP11B ATP11C TMEM41B	1.67e-03	196	128	6	GO:0005319
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.77e-03	10	128	2	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C1 AKR1C2	1.77e-03	10	128	2	GO:0032052
GeneOntologyMolecularFunction	scaffold protein binding	ADCY5 RYR2 GJA1 P2RX7	3.03e-03	93	128	4	GO:0097110
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR51A4 OR51A2 MCHR2 GPR87 ADGRV1 OR52P1 AKR1C1 AKR1C2 ADCY5 EDNRB RIT2 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 ACKR3 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 CAMKMT TAAR1 OR56A1 NMBR ADGRF1	1.15e-09	1395	127	30	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR51A4 OR51A2 OR52P1 RYR2 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 OR56A1	3.66e-09	524	127	18	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of smell	OR51A4 OR51A2 OR52P1 OR52J3 OR52E2 OR2W3 TTC8 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 OR52E5 OR2D2 OR56A1	4.10e-09	465	127	17	GO:0007608
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR51A4 OR51A2 OR52P1 OR52J3 OR52E2 OR2W3 TTC8 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 OR56A1	7.15e-09	547	127	18	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR51A4 OR51A2 OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 OR56A1	7.67e-09	485	127	17	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR51A4 OR51A2 OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 OR52E5 OR2D2 OR56A1	1.01e-08	432	127	16	GO:0050911
GeneOntologyBiologicalProcess	detection of stimulus	OR51A4 OR51A2 ADGRV1 OR52P1 RYR2 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 CAMKMT OR56A1	1.76e-08	722	127	20	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR51A4 OR51A2 ADGRV1 OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 OR56A1	1.86e-08	582	127	18	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR51A4 OR51A2 ADGRV1 OR52P1 SLC1A3 OR52J3 OR52E2 OR2W3 TTC8 OR52I2 OR52R1 OR52I1 OR52A4P P2RX7 OR2AT4 OR52N2 OR52E1 TAS1R2 OR52E5 OR2D2 ULK4 OR56A1 CNGA3	1.47e-07	1072	127	23	GO:0007600
GeneOntologyBiologicalProcess	phospholipid translocation	PLSCR5 CLPTM1L ATP11B P2RX7 ATP11C TMEM41B	1.10e-06	55	127	6	GO:0045332
GeneOntologyBiologicalProcess	lipid translocation	PLSCR5 CLPTM1L ATP11B P2RX7 ATP11C TMEM41B	1.85e-06	60	127	6	GO:0034204
GeneOntologyBiologicalProcess	regulation of membrane lipid distribution	PLSCR5 CLPTM1L ATP11B P2RX7 ATP11C TMEM41B	2.97e-06	65	127	6	GO:0097035
GeneOntologyBiologicalProcess	plasma membrane phospholipid scrambling	PLSCR5 CLPTM1L P2RX7 TMEM41B	1.84e-05	26	127	4	GO:0017121
GeneOntologyBiologicalProcess	phospholipid transport	PLSCR5 CLPTM1L ATP11B P2RX7 ATP11C TMEM41B	4.99e-05	106	127	6	GO:0015914
GeneOntologyBiologicalProcess	organophosphate ester transport	PLSCR5 GJA1 CLPTM1L ATP11B P2RX7 ATP11C TMEM41B	6.57e-05	162	127	7	GO:0015748
GeneOntologyBiologicalProcess	co-translational protein modification	STT3A STT3B	1.12e-04	3	127	2	GO:0043686
GeneOntologyBiologicalProcess	negative regulation of adenylate cyclase activity	GPR87 ADGRV1 EDNRB	1.74e-04	18	127	3	GO:0007194
GeneOntologyBiologicalProcess	negative regulation of cyclase activity	GPR87 ADGRV1 EDNRB	2.06e-04	19	127	3	GO:0031280
GeneOntologyBiologicalProcess	atrial cardiac muscle cell to AV node cell communication	RYR2 GJA1 KCNN2	2.06e-04	19	127	3	GO:0086066
GeneOntologyBiologicalProcess	atrial cardiac muscle cell to AV node cell signaling	RYR2 GJA1 KCNN2	2.06e-04	19	127	3	GO:0086026
GeneOntologyBiologicalProcess	atrial cardiac muscle cell action potential	RYR2 GJA1 KCNN2	2.06e-04	19	127	3	GO:0086014
GeneOntologyBiologicalProcess	response to jasmonic acid	AKR1C1 AKR1C2	2.24e-04	4	127	2	GO:0009753
GeneOntologyBiologicalProcess	progesterone catabolic process	AKR1C1 AKR1C2	2.24e-04	4	127	2	GO:0006709
GeneOntologyBiologicalProcess	cellular response to jasmonic acid stimulus	AKR1C1 AKR1C2	2.24e-04	4	127	2	GO:0071395
GeneOntologyBiologicalProcess	C21-steroid hormone catabolic process	AKR1C1 AKR1C2	2.24e-04	4	127	2	GO:0008208
GeneOntologyBiologicalProcess	negative regulation of lyase activity	GPR87 ADGRV1 EDNRB	3.22e-04	22	127	3	GO:0051350
GeneOntologyBiologicalProcess	farnesol metabolic process	AKR1C1 AKR1C2	3.72e-04	5	127	2	GO:0016487
GeneOntologyBiologicalProcess	farnesol catabolic process	AKR1C1 AKR1C2	3.72e-04	5	127	2	GO:0016488
GeneOntologyBiologicalProcess	negative regulation of isoprenoid metabolic process	AKR1C1 AKR1C2	3.72e-04	5	127	2	GO:0045827
GeneOntologyBiologicalProcess	sesquiterpenoid catabolic process	AKR1C1 AKR1C2	3.72e-04	5	127	2	GO:0016107
GeneOntologyBiologicalProcess	olefinic compound catabolic process	AKR1C1 AKR1C2	3.72e-04	5	127	2	GO:0120256
GeneOntologyBiologicalProcess	negative regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	3.72e-04	5	127	2	GO:1900053
GeneOntologyBiologicalProcess	protein N-linked glycosylation via asparagine	RPN1 STT3A STT3B	4.20e-04	24	127	3	GO:0018279
GeneOntologyBiologicalProcess	response to calcium ion	ADGRV1 AKR1C1 AKR1C2 RYR2 P2RX7 ALOX15	4.89e-04	161	127	6	GO:0051592
GeneOntologyBiologicalProcess	sesquiterpenoid metabolic process	AKR1C1 AKR1C2	5.55e-04	6	127	2	GO:0006714
GeneOntologyBiologicalProcess	polyprenol catabolic process	AKR1C1 AKR1C2	5.55e-04	6	127	2	GO:0016095
GeneOntologyBiologicalProcess	negative regulation of mRNA splicing, via spliceosome	PTBP3 AKR1C1 AKR1C2	6.67e-04	28	127	3	GO:0048025
GeneOntologyBiologicalProcess	negative regulation of mRNA processing	PTBP3 AKR1C1 AKR1C2	7.41e-04	29	127	3	GO:0050686
GeneOntologyBiologicalProcess	lipid localization	ACACB PLSCR5 ABCA13 SPG11 AKR1C1 ACSL3 CLPTM1L ATP11B P2RX7 ATP11C TMEM41B	7.50e-04	565	127	11	GO:0010876
GeneOntologyBiologicalProcess	response to prostaglandin D	AKR1C1 AKR1C2	7.74e-04	7	127	2	GO:0071798
GeneOntologyBiologicalProcess	cellular response to prostaglandin D stimulus	AKR1C1 AKR1C2	7.74e-04	7	127	2	GO:0071799
GeneOntologyBiologicalProcess	regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	7.74e-04	7	127	2	GO:1900052
GeneOntologyCellularComponent	oligosaccharyltransferase complex	RPN1 STT3A STT3B	7.77e-05	14	128	3	GO:0008250
Domain	7tm_1	OR51A4 OR51A2 MCHR2 GPR87 EDNRB OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 ACKR3 OR52N2 OR52E5 OR2D2 TAAR1 OR56A1 NMBR	1.53e-08	677	122	20	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR51A4 OR51A2 MCHR2 GPR87 EDNRB OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 ACKR3 OR52N2 OR52E5 OR2D2 TAAR1 OR56A1 NMBR	1.86e-08	685	122	20	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR51A4 OR51A2 MCHR2 GPR87 EDNRB OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 ACKR3 OR52N2 OR52E5 OR2D2 TAAR1 OR56A1 NMBR	2.15e-08	691	122	20	PS50262
Domain	GPCR_Rhodpsn	OR51A4 OR51A2 MCHR2 GPR87 EDNRB OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 ACKR3 OR52N2 OR52E5 OR2D2 TAAR1 OR56A1 NMBR	2.20e-08	692	122	20	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR51A4 OR51A2 MCHR2 GPR87 EDNRB OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 ACKR3 OR52N2 OR2D2 TAAR1 OR56A1 NMBR	6.95e-08	670	122	19	IPR017452
Domain	Olfact_rcpt	OR51A4 OR51A2 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR52A4P OR2AT4 OR52N2 OR52E5 OR2D2 OR56A1	2.89e-07	393	122	14	IPR000725
Domain	Oligo_trans_STT3	STT3A STT3B	4.23e-05	2	122	2	IPR003674
Domain	STT3	STT3A STT3B	4.23e-05	2	122	2	PF02516
Domain	7TM_GPCR_Srsx	OR51A4 OR51A2 EDNRB TAAR1 OR56A1 NMBR	9.34e-05	112	122	6	SM01381
Domain	HEAT_REPEAT	PDS5B PIK3R4 MROH7 ULK4 IPO11	9.44e-05	70	122	5	PS50077
Domain	ARM-type_fold	PDS5B TMCO6 TRIP12 PIK3R4 URB1 MROH7 ULK4 ATM IPO11	3.89e-04	339	122	9	IPR016024
Domain	-	PDS5B TMCO6 TRIP12 PIK3R4 MROH7 ULK4 IPO11	6.43e-04	222	122	7	1.25.10.10
Domain	HECT	TRIP12 HACE1 UBE3C	7.09e-04	27	122	3	PF00632
Domain	HECTc	TRIP12 HACE1 UBE3C	7.09e-04	27	122	3	SM00119
Domain	HECT_dom	TRIP12 HACE1 UBE3C	7.09e-04	27	122	3	IPR000569
Domain	HECT	TRIP12 HACE1 UBE3C	7.09e-04	27	122	3	PS50237
Pathway	REACTOME_SENSORY_PERCEPTION	OR51A4 OR51A2 AKR1C1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR52E1 TAS1R2 KCNN2 OR52E5 OR2D2 CAMKMT OR56A1	2.02e-07	636	95	18	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR51A4 OR51A2 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR52E1 OR52E5 OR2D2 OR56A1	7.28e-07	417	95	14	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR51A4 OR51A2 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR2D2 OR56A1 CNGA3	1.98e-06	389	95	13	M14091
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST	RPN1 STT3A STT3B	4.70e-05	11	95	3	M47614
Pathway	WP_FERROPTOSIS	IREB2 AKR1C1 AKR1C2 ACSL3 ALOX15	6.96e-05	64	95	5	M39768
Pubmed	Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.	RPN1 STT3A STT3B	4.99e-08	3	129	3	19167329
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR52E5 OR2D2	6.32e-08	340	129	11	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR52E5 OR2D2	6.32e-08	340	129	11	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR52E5 OR2D2	6.91e-08	343	129	11	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR52E5 OR2D2	7.54e-08	346	129	11	14611657
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	BRIX1 PDS5B NRDC RPN1 DYNC2H1 POLE TOE1 STT3A STT3B PIK3R4 PSMD6 ACSL3 CLPTM1L URB1 UBE2O DDX18 CPSF1 TLN2 ATM UBE3C	3.12e-07	1425	129	20	30948266
Pubmed	The human olfactory receptor gene family.	OR52P1 OR52J3 OR52E2 OR2W3 OR52I2 OR52R1 OR52I1 OR2AT4 OR52N2 OR52E5 OR2D2 OR56A1	8.95e-07	541	129	12	14983052
Pubmed	OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.	RPN1 STT3A STT3B	9.89e-07	6	129	3	23606741
Pubmed	Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.	RPN1 STT3A STT3B	9.89e-07	6	129	3	12887896
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PDS5B RPN1 DYNC2H1 POLE TRIP12 STT3A STT3B AAR2 ACSL3 GJA1 URB1 UBE2O STC2 TMEM41B IPO11	2.35e-06	942	129	15	31073040
Pubmed	Gene essentiality and synthetic lethality in haploid human cells.	RPN1 UNC50 STT3A STT3B AAR2 UBE2O DDX18 CLEC16A	2.40e-06	229	129	8	26472760
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PDS5B ACACB RASGRF2 SPG11 TRIP12 TOE1 PIK3R4 CPSF1 ATM MUC4 IPO11	2.66e-06	497	129	11	36774506
Pubmed	Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.	RPN1 STT3A STT3B	8.05e-06	11	129	3	31831667
Pubmed	Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.	RPN1 STT3A STT3B	1.07e-05	12	129	3	15835887
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	1.37e-05	2	129	2	8573067
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	1.37e-05	2	129	2	15492289
Pubmed	Mutations in STT3A and STT3B cause two congenital disorders of glycosylation.	STT3A STT3B	1.37e-05	2	129	2	23842455
Pubmed	Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites.	STT3A STT3B	1.37e-05	2	129	2	31296534
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	1.37e-05	2	129	2	21217827
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	1.37e-05	2	129	2	8486699
Pubmed	Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.	AKR1C1 AKR1C2	1.37e-05	2	129	2	11514561
Pubmed	Toll-like receptor 5 and 8 in hepatocellular carcinoma.	TLR8 TLR5	1.37e-05	2	129	2	33950532
Pubmed	Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors.	GJA1 P2RX7	1.37e-05	2	129	2	15331634
Pubmed	The middle X residue influences cotranslational N-glycosylation consensus site skipping.	STT3A STT3B	1.37e-05	2	129	2	25029371
Pubmed	Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart.	RYR2 GJA1	1.37e-05	2	129	2	26316108
Pubmed	Proteome and Glycoproteome Analyses Reveal the Protein N-Linked Glycosylation Specificity of STT3A and STT3B.	STT3A STT3B	1.37e-05	2	129	2	36139350
Pubmed	cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.	AKR1C1 AKR1C2	1.37e-05	2	129	2	8011662
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	1.37e-05	2	129	2	18654764
Pubmed	Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study.	TLR8 TLR5	1.37e-05	2	129	2	32854231
Pubmed	RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes.	RYR2 GJA1	1.37e-05	2	129	2	31841141
Pubmed	Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.	STT3A STT3B	1.37e-05	2	129	2	30181269
Pubmed	The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.	AKR1C1 AKR1C2	1.37e-05	2	129	2	26934124
Pubmed	Whole exome sequencing in recurrent early pregnancy loss.	DYNC2H1 ALOX15	1.37e-05	2	129	2	26826164
Pubmed	High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies.	RPN1 ACKR3 CPSF1	3.26e-05	17	129	3	21966449
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2	4.09e-05	3	129	2	19320734
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2	4.09e-05	3	129	2	31780644
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2	4.09e-05	3	129	2	13678667
Pubmed	Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.	AKR1C1 AKR1C2	4.09e-05	3	129	2	22064385
Pubmed	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.	STT3A STT3B	4.09e-05	3	129	2	29765039
Pubmed	Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation.	GJA1 P2RX7	4.09e-05	3	129	2	32103010
Pubmed	Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex.	RYR2 GJA1	4.09e-05	3	129	2	32713021
Pubmed	Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions.	ADGRF1 MUC4	4.09e-05	3	129	2	28866095
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2	4.09e-05	3	129	2	21232532
Pubmed	Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone.	SLC1A3 GJA1	4.09e-05	3	129	2	37043357
Pubmed	Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca2+ transients and neurovascular coupling.	SLC1A3 GJA1	4.09e-05	3	129	2	30883940
Pubmed	Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?	GJA1 P2RX7	4.09e-05	3	129	2	22797941
Pubmed	Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis.	SLC1A3 GJA1	4.09e-05	3	129	2	16652340
Pubmed	Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency.	RYR2 CNGA3	4.09e-05	3	129	2	31182474
Pubmed	A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.	PTBP3 AKR1C1 AKR1C2	5.43e-05	20	129	3	23636947
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C1 AKR1C2	8.15e-05	4	129	2	10500239
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C1 AKR1C2	8.15e-05	4	129	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	8.15e-05	4	129	2	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C1 AKR1C2	8.15e-05	4	129	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C1 AKR1C2	8.15e-05	4	129	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C1 AKR1C2	8.15e-05	4	129	2	31479646
Pubmed	Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.	SLC1A3 P2RX7	8.15e-05	4	129	2	20070863
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C1 AKR1C2	8.15e-05	4	129	2	16191478
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C1 AKR1C2	8.15e-05	4	129	2	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C1 AKR1C2	8.15e-05	4	129	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C1 AKR1C2	8.15e-05	4	129	2	17034817
Pubmed	Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning.	SLC1A3 GJA1	8.15e-05	4	129	2	35263595
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C1 AKR1C2	8.15e-05	4	129	2	29764944
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C1 AKR1C2	8.15e-05	4	129	2	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C1 AKR1C2	8.15e-05	4	129	2	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C1 AKR1C2	8.15e-05	4	129	2	28329705
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C1 AKR1C2	8.15e-05	4	129	2	19237748
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C1 AKR1C2	8.15e-05	4	129	2	28259989
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	8.15e-05	4	129	2	16511129
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C1 AKR1C2	8.15e-05	4	129	2	7789999
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C1 AKR1C2	8.15e-05	4	129	2	20124700
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C1 AKR1C2	8.15e-05	4	129	2	16508162
Pubmed	Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.	ADCY5 P2RX7	8.15e-05	4	129	2	22250198
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	8.15e-05	4	129	2	15222881
Pubmed	Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase.	STT3A STT3B	8.15e-05	4	129	2	22266900
Pubmed	Potential contribution of ryanodine receptor 2 upregulation to cGMP/PKG signaling-induced cone degeneration in cyclic nucleotide-gated channel deficiency.	RYR2 CNGA3	8.15e-05	4	129	2	32173907
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C1 AKR1C2	8.15e-05	4	129	2	17629694
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C1 AKR1C2	8.15e-05	4	129	2	10526179
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C1 AKR1C2	8.15e-05	4	129	2	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	8.15e-05	4	129	2	17272929
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C1 AKR1C2	8.15e-05	4	129	2	18667791
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C1 AKR1C2	8.15e-05	4	129	2	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	8.15e-05	4	129	2	8274401
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C1 AKR1C2	8.15e-05	4	129	2	10803568
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C1 AKR1C2	8.15e-05	4	129	2	34590152
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DYNC2H1 POLE SLC1A3 AAR2 PSMD6 ACSL3 CPSF1 UBE3C CLEC16A IPO11	9.21e-05	606	129	10	36538041
Pubmed	Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.	AKR1C1 AKR1C2 GJA1	1.08e-04	25	129	3	26098214
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	DYNC2H1 NUP210L AKR1C1 AKR1C2 STT3A ACSL3 DDX18 CPSF1 ULK4 ROS1 TMEM41B	1.21e-04	754	129	11	35906200
Pubmed	Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.	MED6 GJA1 MED13	1.22e-04	26	129	3	34506481
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	SLC1A3 TOE1 STT3A STT3B CLPTM1L URB1 STC2	1.24e-04	296	129	7	34186245
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TRIP12 FEM1B HACE1 CADPS2 MED13	1.28e-04	130	129	5	12421765
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	BRIX1 RPN1 DYNC2H1 POLE SPG11 STT3A STT3B AAR2 ACSL3 GJA1 CLPTM1L URB1 UBE2O VANGL1 DDX18 ATM	1.29e-04	1487	129	16	33957083
Pubmed	NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47.	URB1 DDX18	1.36e-04	5	129	2	16963496
Pubmed	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.	AKR1C1 AKR1C2	1.36e-04	5	129	2	21851338
Pubmed	ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum.	ATP11B ATP11C	1.36e-04	5	129	2	31571211
Pubmed	Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.	AKR1C1 AKR1C2	1.36e-04	5	129	2	15212687
Pubmed	Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.	AKR1C1 AKR1C2	1.36e-04	5	129	2	16984997
Pubmed	Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.	AKR1C1 AKR1C2	1.36e-04	5	129	2	7737980
Pubmed	Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.	AKR1C1 AKR1C2	1.36e-04	5	129	2	17872381
Pubmed	Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.	AKR1C1 AKR1C2	1.36e-04	5	129	2	17064890
Pubmed	Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.	AKR1C1 AKR1C2	1.36e-04	5	129	2	10672042
Cytoband	11p15.4	OR51A4 OR51A2 OR52P1 OR52J3 OR52E2 OR52I2 OR52R1 OR52I1 OR52A4P OR52N2 OR52E1 OR52E5 OR2D2 TMEM41B OR56A1	2.20e-17	200	129	15	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51A4 OR51A2 OR52P1 OR52J3 OR52E2 OR52I2 OR52R1 OR52I1 OR52A4P OR52N2 OR52E1 OR52E5 OR2D2 TMEM41B OR56A1	7.54e-11	564	129	15	chr11p15
Cytoband	10p15-p14	AKR1C1 AKR1C2	1.17e-04	6	129	2	10p15-p14
Cytoband	Ensembl 112 genes in cytogenetic band chr6q16	MCHR2 FBXL4 HACE1	5.39e-04	56	129	3	chr6q16
Cytoband	2p22.1	THUMPD2 ARHGEF33	9.16e-04	16	129	2	2p22.1
Cytoband	2q11.2	UNC50 FER1L5 CNGA3	1.12e-03	72	129	3	2q11.2
Cytoband	5q13	RASGRF2 ADGRV1	1.74e-03	22	129	2	5q13
GeneFamily	Olfactory receptors, family 52	OR52P1 OR52J3 OR52E2 OR52I2 OR52R1 OR52I1 OR52A4P OR52N2 OR52E1 OR52E5	2.75e-14	49	87	10	165
GeneFamily	STT3 oligosaccharyltransferase catalytic subunits\|Oligosaccharyltransferase complex subunits	STT3A STT3B	2.29e-05	2	87	2	444
GeneFamily	Oligosaccharyltransferase complex subunits	RPN1 STT3A STT3B	2.29e-05	12	87	3	445
GeneFamily	CD molecules\|Toll like receptors	TLR8 TLR5	1.00e-03	10	87	2	948
GeneFamily	Aldo-keto reductases	AKR1C1 AKR1C2	2.31e-03	15	87	2	399
GeneFamily	ATPase phospholipid transporting	ATP11B ATP11C	2.31e-03	15	87	2	1210
GeneFamily	Gap junction proteins	GJA1 GJE1	4.97e-03	22	87	2	314
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2C18 ABCA13 AKR1C1 AKR1C2 FAT2 ACKR3 MUC4 ALOX15	1.07e-07	197	128	8	233b9fcb376e08d0080a05ca0198ecc6ec720f90
ToppCell	distal-3-Epithelial-Goblet\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LARGE2 ABCA13 GPR87 AKR1C1 G6PC2 ADGRF1 MUC4 ALOX15	1.07e-07	197	128	8	a00784ccfb1de6a96b91e2a8a2889b69f31a33da
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2C18 ABCA13 GPR87 AKR1C1 AKR1C2 FAT2 MUC4 ALOX15	1.11e-07	198	128	8	6e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 RPS6KA2 AKR1C2 DIPK2B GJA1 CLEC16A IPO11	7.31e-07	174	128	7	4a18b51501eaaeb7907e99316ba8ae15b2c7d529
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 GPR87 AKR1C2 FAT2 ADGRF1 MUC4 ALOX15	9.18e-07	180	128	7	535a890bde0d978b461c2d4c571529b585c76b21
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ABCA13 ADGRV1 RYR2 ASXL3 TLN2 ROS1	1.06e-06	184	128	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ABCA13 ADGRV1 RYR2 ASXL3 TLN2 ROS1	1.06e-06	184	128	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ABCA13 ADGRV1 RYR2 ASXL3 TLN2 ROS1	1.06e-06	184	128	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	distal-Epithelial-Goblet\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LARGE2 ABCA13 GPR87 AKR1C1 G6PC2 MUC4 ALOX15	1.68e-06	197	128	7	da1ed7303cc9cb2d205c0e5c49c52544d3540951
ToppCell	3'-Broncho-tracheal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 GPR87 AKR1C1 AKR1C2 FAT2 MUC4 ALOX15	1.68e-06	197	128	7	5d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCell	distal-Epithelial-Goblet-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LARGE2 ABCA13 GPR87 AKR1C1 G6PC2 MUC4 ALOX15	1.68e-06	197	128	7	3fbf456ae4f73da4f6254a6f0d24f0ec27d7a3cc
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2C18 ABCA13 GPR87 AKR1C2 FAT2 ASXL3 MUC4	1.73e-06	198	128	7	de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCell	3'-Broncho-tracheal-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 GPR87 AKR1C1 AKR1C2 FAT2 MUC4 ALOX15	1.73e-06	198	128	7	aa6e7218ee6230902854e66c444b544218b30c0e
ToppCell	NS-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 AKR1C1 AKR1C2 CADPS2 ADGRF1 MUC4 ALOX15	1.73e-06	198	128	7	4a481e1edb80b950c823ed926842cd5132cfb27f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 GPR87 ADARB2 AKR1C2 FAT2 MUC4 ALOX15	1.79e-06	199	128	7	f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2C18 ABCA13 GPR87 AKR1C2 FAT2 MUC4 ALOX15	1.85e-06	200	128	7	5f0f67958c9635db53e61f8370a92da6ea3e80fe
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 GPR87 ADARB2 FAT2 ASXL3 MUC4 ALOX15	1.85e-06	200	128	7	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2C18 ABCA13 GPR87 AKR1C2 FAT2 MUC4 ALOX15	1.85e-06	200	128	7	ce969c958a31145bbfe315a9a865d7900ecc9549
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RASGRF2 ADARB2 LEFTY2 KCNN2 ATP11C NMBR	7.76e-06	163	128	6	bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RASGRF2 ADARB2 LEFTY2 KCNN2 ATP11C NMBR	8.04e-06	164	128	6	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|368C / Donor, Lineage, Cell class and subclass (all cells)	RPS6KA2 EDNRB DIPK2B STC2 HACE1 KCNN2	8.62e-06	166	128	6	30a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	RPS6KA2 EDNRB DIPK2B STC2 HACE1 KCNN2	8.62e-06	166	128	6	76b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 NUP210L AKR1C1 DIPK2B GJA1 IPO11	8.62e-06	166	128	6	941d6aa94ab9d36e5f6c40f446c926754e070d56
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 NUP210L AKR1C1 DIPK2B GJA1 IPO11	8.62e-06	166	128	6	6f5ecf3b2cf613ae0535ab3d21d93622f1497571
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACB RPS6KA2 ADARB2 ADCY5 DIPK2B TMEM245	9.87e-06	170	128	6	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	1.02e-05	171	128	6	25c1979e972c959e1ce4c57804f976f53a247ad7
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	1.02e-05	171	128	6	fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 RPS6KA2 EDNRB DIPK2B GJA1 ACKR3	1.09e-05	173	128	6	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	COPD-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	RASGRF2 DIPK2B GJA1 STC2 G6PC2 CADPS2	1.59e-05	185	128	6	4abe04198ab5047c211f8d09cdb9650fa52a3cd6
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRIX1 SLC35G2 DIPK2B GJA1 STC2 ACKR3	1.80e-05	189	128	6	e002dbb2138a6264be23f3b8148275a0cef351ef
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 RPS6KA2 DIPK2B GJA1 CFAP54 ACKR3	1.85e-05	190	128	6	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 AKR1C1 AKR1C2 DIPK2B GJA1 IPO11	1.85e-05	190	128	6	32400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 AKR1C1 AKR1C2 DIPK2B GJA1 IPO11	1.85e-05	190	128	6	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 RPS6KA2 DIPK2B GJA1 CFAP54 ACKR3	1.85e-05	190	128	6	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRIX1 SLC35G2 DIPK2B GJA1 STC2 ACKR3	1.85e-05	190	128	6	a318d80dd5cc33d43048883b0e7844b5aa280aab
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 RPS6KA2 DIPK2B GJA1 CFAP54 ACKR3	1.85e-05	190	128	6	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	STAB2 AKR1C1 AKR1C2 DIPK2B GJA1 IPO11	1.85e-05	190	128	6	103e78c2233c3ee0c215a9dafe70705477e9ee5e
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2C18 ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4	1.91e-05	191	128	6	529068029fb461df766135576dd0d8b5980f9bc0
ToppCell	human_hepatoblastoma-Endothelial_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	RPS6KA2 EDNRB DIPK2B GJA1 ACKR3 ATP11C	1.97e-05	192	128	6	e09f609fed033a25baacaf4a07bbbae1076da366
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 AKR1C1 AKR1C2 DIPK2B GJA1 IPO11	1.97e-05	192	128	6	5388f3115ab285f3f3001af1d71543ed64b9e044
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 AKR1C1 AKR1C2 DIPK2B GJA1 IPO11	2.03e-05	193	128	6	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 AKR1C1 AKR1C2 URB1 ASXL3 MUC4	2.09e-05	194	128	6	e0228f593c3493175962a4817500d4337ddc4e88
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2C18 AKR1C1 AKR1C2 FAT2 MUC4 ALOX15	2.15e-05	195	128	6	24d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell	3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 AKR1C1 EDNRB DIPK2B OTC IPO11	2.21e-05	196	128	6	aa52f77f80c3fe23369347a34e0b3188b768a763
ToppCell	cellseq-Epithelial-Epithelial_Airway\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 GPR87 AKR1C1 FAT2 MUC4 ALOX15	2.21e-05	196	128	6	faa39c567f24403e511b240c1d1a654ffadd8473
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2C18 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.27e-05	197	128	6	ec08a971e8dd9ad69359896c60ad77ff8af08fd0
ToppCell	Severe_COVID-19-Epithelial-transitional_Epi\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	DYNC2H1 ABCA13 AKR1C1 ADGRF1 MUC4 ALOX15	2.27e-05	197	128	6	5ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR87 AKR1C1 AKR1C2 FAT2 MUC4 ALOX15	2.34e-05	198	128	6	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR87 AKR1C1 AKR1C2 FAT2 MUC4 ALOX15	2.34e-05	198	128	6	89ec1e760a193441092571475cc66a3b425f232e
ToppCell	BL-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.34e-05	198	128	6	484d16aaa601a1e11b871b0475dd01a2de1a29ce
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2C18 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.34e-05	198	128	6	3cc9e671f596ef0829684018e4257571fefb6267
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 AKR1C2 FAT2 ADGRF1 MUC4 ALOX15	2.34e-05	198	128	6	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	Biopsy_IPF-Endothelial-Lymphatic_Endothelial_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	STAB2 SLC35G2 EDNRB DIPK2B GJA1 ACKR3	2.41e-05	199	128	6	483b01f1308eb201a1ff3788fe656c486b6b9e66
ToppCell	NS-moderate-d_16-33-Epithelial\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.41e-05	199	128	6	aa2b51940115c22768c0d7493b4b60d41df3f376
ToppCell	Biopsy_Control_(H.)-Epithelial-MUC5AC+_High\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CYP2C18 GPR87 AKR1C1 FAT2 ADGRF1 MUC4	2.41e-05	199	128	6	a5240868cea40574ed4ee45eb27a00c1812957ed
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GPR87 AKR1C1 AKR1C2 FAT2 ADGRF1 MUC4	2.47e-05	200	128	6	c7668e26c6b8cfa6d174b0634e43c230425faba9
ToppCell	moderate-Epithelial\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.47e-05	200	128	6	095783c9b75113ae350c2d5fb1195d71b41fa695
ToppCell	Parenchyma_COVID-19-Epithelial-TX-Basal_2\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	GPR87 AKR1C1 AKR1C2 FAT2 ADGRF1 MUC4	2.47e-05	200	128	6	bce9bce9eb622bc6514708d49ca4a6604043c22a
ToppCell	NS-moderate-d_07-13-Epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.47e-05	200	128	6	85940b4bf7971b872469dea8b8d7a45bdeb2a909
ToppCell	Severe-Epithelial-Epithelial-\|Severe / Condition, Lineage, Cell class and cell subclass	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.47e-05	200	128	6	8669ce08f93eefb8ac970e30cdc4b1f908023c54
ToppCell	Severe-Epithelial\|Severe / Condition, Lineage, Cell class and cell subclass	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.47e-05	200	128	6	6ead9db88568bb829d564a6d8e85f71fd765bac0
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPR87 AKR1C1 AKR1C2 FAT2 ADGRF1 MUC4	2.47e-05	200	128	6	621dd6438ef6e71811d3644b75209535b7c0f8f7
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 GPR87 AKR1C2 FAT2 MUC4 ALOX15	2.47e-05	200	128	6	2a9d715aba8bdef2341b0d44ff60825c074a4b03
ToppCell	Severe-Epithelial-Epithelial\|Severe / Condition, Lineage, Cell class and cell subclass	ABCA13 AKR1C1 AKR1C2 ADGRF1 MUC4 ALOX15	2.47e-05	200	128	6	3bd1ce2793651c9badd69f011d2531183594e5f4
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ABCA13 ADGRV1 EDNRB OR2W3 MROH7	3.19e-05	126	128	5	69b2525b92d1c7c35b21cc701f5fa52a9c1b94bb
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ABCA13 ADGRV1 EDNRB OR2W3 MROH7	3.19e-05	126	128	5	6cb89754010d64875e115da6c5805efac7a4a82d
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Pitx2_(Subthalamic_Nucleus_(STN),_maybe_ENT_as_well)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LARGE2 PLSCR5 FER1L5 CNGA3	3.48e-05	64	128	4	77fcb80a2c56aef754dd5eb327a39c698766ebcf
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Pitx2_(Subthalamic_Nucleus_(STN),_maybe_ENT_as_well)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LARGE2 PLSCR5 FER1L5 CNGA3	3.48e-05	64	128	4	ce0c117d29057640f2be09c3a4cde7733bf2f5ac
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LARGE2 PLSCR5 FER1L5 CNGA3	3.48e-05	64	128	4	5bfbacbd39dd176a29703e2a99644b465a50c655
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LARGE2 PLSCR5 FER1L5 CNGA3	3.48e-05	64	128	4	f56966e8f54db8f973533166e0ae4dd829a390c9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 FAM227B ADCY5 CFAP54 ULK4	5.84e-05	143	128	5	7a7a9829ba63468c9745904d9e993590051207ab
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 POLE ADGRV1 ROS1 ADGRF1	6.24e-05	145	128	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 RPS6KA2 DIPK2B GJA1 CFAP54	1.02e-04	161	128	5	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 RPS6KA2 DIPK2B GJA1 CFAP54	1.02e-04	161	128	5	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	Club_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	AKR1C1 AKR1C2 ASXL3 ADGRF1 MUC4	1.28e-04	169	128	5	03b303af8a26c6ff196507fe24f5bd3d75d7b1af
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LARGE2 ADARB2 AKR1C2 FAT2 ALOX15	1.32e-04	170	128	5	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LARGE2 ADARB2 AKR1C2 FAT2 ALOX15	1.32e-04	170	128	5	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	ABCA13 GPR87 ADARB2 FAT2 MUC4	1.36e-04	171	128	5	3965ced4be6db14265a90673502fceee425837ca
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 ULK4 TAAR1 G6PC2 MUC4	1.47e-04	174	128	5	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ABCA13 GPR87 FAT2 ADGRF1 MUC4	1.47e-04	174	128	5	9e5fae9ecc7c0111fc8a252e72b89dc89c0d3a7c
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 RIT2 GJA1 TLR5 IPO11	1.51e-04	175	128	5	9d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 RIT2 GJA1 TLR5 IPO11	1.51e-04	175	128	5	f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATCAY MOSPD1 GJA1 FAT2 ADGRF1	1.51e-04	175	128	5	c1a8a55af825d5913095f919fa860828df9c273e
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATCAY MOSPD1 GJA1 FAT2 ADGRF1	1.51e-04	175	128	5	78b453e220218c84557f244ef7a760e4a1952761
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-5_THEMIS_ELOF1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MCHR2 AKR1C1 RIT2 OR52E1 CADPS2	1.55e-04	176	128	5	78306517b1e52411a2ba72f141efea4d12c09f25
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RPS6KA2 GJA1 MIR17HG ACKR3 IPO11	1.59e-04	177	128	5	227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCell	metastatic_Lymph_Node-Endothelial_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	STAB2 DIPK2B GJA1 ASXL3 IPO11	1.59e-04	177	128	5	71bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RPS6KA2 GJA1 MIR17HG ACKR3 IPO11	1.59e-04	177	128	5	66ffa279147961080c104242a08b176e301d80e3
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STAB2 EDNRB DIPK2B GJA1 ACKR3	1.59e-04	177	128	5	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 EDNRB DIPK2B GJA1 IPO11	1.59e-04	177	128	5	b1775e05c28883a15c56628028770bc59d3233fb
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RPS6KA2 GJA1 MIR17HG ACKR3 IPO11	1.59e-04	177	128	5	0cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	STAB2 DIPK2B GJA1 STC2 KCNN2	1.59e-04	177	128	5	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 RASGRF2 RPS6KA2 DISP2 AKAP10	1.59e-04	177	128	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS12 GPR87 FAT2 STC2 G6PC2	1.64e-04	178	128	5	445fb243d738a34794d66f34b92dde1f3ea6738e
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-basal_proximal\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CYP2C18 GPR87 FAT2 ACKR3 MUC4	1.64e-04	178	128	5	9534c4f4e950bb1498c1737ca1713e7f37d0aff2
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 ULK4 TAAR1 G6PC2 MUC4	1.64e-04	178	128	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MCHR2 AKR1C1 AKR1C2 RIT2 CADPS2	1.64e-04	178	128	5	a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MCHR2 AKR1C1 AKR1C2 RIT2 CADPS2	1.68e-04	179	128	5	820289f14ecf165758529c236bb220bb1a744f02
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 RPS6KA2 DIPK2B GJA1 IPO11	1.68e-04	179	128	5	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 ADGRV1 URB1 ADGRF1 MUC4	1.68e-04	179	128	5	6e965e424eebef50f0202cff75f458be395cfca1
Disease	congenital disorder of glycosylation Iw (implicated_via_orthology)	STT3A STT3B	1.70e-05	2	122	2	DOID:0080572 (implicated_via_orthology)
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	5.07e-05	3	122	2	C0027661
Disease	lung squamous cell carcinoma (is_implicated_in)	POLE CLPTM1L ATM	1.31e-04	24	122	3	DOID:3907 (is_implicated_in)
Disease	Hermaphroditism	AKR1C1 AKR1C2	1.68e-04	5	122	2	C0019269
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	1.68e-04	5	122	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	1.68e-04	5	122	2	C0033804
Disease	Intersex Conditions	AKR1C1 AKR1C2	1.68e-04	5	122	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	1.68e-04	5	122	2	C2930619
Disease	Hyperammonemia	OTC TLR5	3.51e-04	7	122	2	C0220994
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	3.51e-04	7	122	2	C0036875
Disease	blood titanium measurement	OR52E2 OR52E1 CLEC16A	4.46e-04	36	122	3	EFO_0021532
Disease	alopecia, response to thiopurine	CYP2C18 ADGRF1	4.67e-04	8	122	2	EFO_0006317, MONDO_0004907
Disease	Inherited neuropathies	SPG11 SLC1A3 ATM	6.09e-04	40	122	3	C0598589
Disease	Adenocarcinoma of large intestine	POLE RPS6KA2 ROS1 ATM	6.89e-04	96	122	4	C1319315
Disease	Small Lymphocytic Lymphoma	P2RX7 ATM	7.47e-04	10	122	2	C0855095
Disease	B-CELL MALIGNANCY, LOW-GRADE	P2RX7 ATM	7.47e-04	10	122	2	C1868683
Disease	Thromboembolism	OR52A4P NMBR ATG16L2	8.07e-04	44	122	3	HP_0001907
Disease	Ciliopathies	DYNC2H1 ADGRV1 LEFTY2 TTC8	1.15e-03	110	122	4	C4277690
Disease	Alzheimer disease, cognitive decline measurement, Cognitive impairment	PDS5B ADARB2	1.28e-03	13	122	2	EFO_0007710, HP_0100543, MONDO_0004975
Disease	oral cavity cancer	FAM227B CLPTM1L	1.49e-03	14	122	2	EFO_0005570
Disease	trimethylamine-N-oxide measurement	TAS1R2 UBE3C	1.49e-03	14	122	2	EFO_0010541
Disease	Malignant neoplasm of breast	RASGRF2 DYNC2H1 MOSPD1 EDNRB PIK3R4 GJA1 CLPTM1L STC2 DDX18 MROH7 ATM NMBR	1.68e-03	1074	122	12	C0006142
Disease	adverse effect, response to xenobiotic stimulus	STAB2 ADARB2 RIT2	1.89e-03	59	122	3	EFO_0009658, GO_0009410
Disease	response to methotrexate	AKR1C1 AKR1C2	1.96e-03	16	122	2	GO_0031427
Disease	body weight	PTBP3 ADGRV1 TRIP12 ADCY5 RIT2 ACSL3 MIR17HG ASXL3 HACE1 ULK4 TLN2 CAMKMT CADPS2	2.19e-03	1261	122	13	EFO_0004338
Disease	Benign neoplasm of stomach	POLE ATM	2.21e-03	17	122	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	POLE ATM	2.21e-03	17	122	2	C0496905
Disease	Carcinoma in situ of stomach	POLE ATM	2.21e-03	17	122	2	C0154060
Disease	neurodegenerative disease (implicated_via_orthology)	NRDC SLC1A3 PSMD6 CLEC16A	3.14e-03	145	122	4	DOID:1289 (implicated_via_orthology)
Disease	Stomach Carcinoma	POLE ATM	3.38e-03	21	122	2	C0699791
Disease	Bipolar Disorder	ABCA13 RPS6KA2 MCHR2 SLC1A3 P2RX7 ULK4 AKAP10	3.76e-03	477	122	7	C0005586
Disease	Disproportionate short stature	DYM DYNC2H1 TBCE	4.04e-03	77	122	3	C0878659
Disease	BMI-adjusted fasting blood glucose measurement	ADCY5 G6PC2	4.05e-03	23	122	2	EFO_0008036

Protein segments in the cluster

Peptide	Gene	Start	Entry
LFIHYLAIVLLELRQ	VANGL1	231	Q8TAA9
QLPRHLDAEQIYLFI	FAM227B	161	Q96M60
LLAPIIYHNIVLVPV	CFAP54	1156	Q96N23
ALFLELVPAYNHLLE	ATG16L2	31	Q8NAA4
HLGPVEEYQLLLQVT	ADGRF1	41	Q5T601
LEQVLHDTIVLPYFI	AKAP10	126	O43572
INLISILYHQLGEIP	AAR2	296	Q9Y312
EGQLPQILHYELLAI	AGO1	671	Q9UL18
NAAEIPLILYLFALI	ADGRV1	6101	Q8WXG9
VQRIPEYLIHLQNVL	ARHGEF33	396	A8MVX0
LPYIVLLVLHNQLSF	ABCA13	3691	Q86UQ4
PHYALLKELLIQIFS	BRIX1	176	Q8TDN6
GDLLHIVIDIPINVY	EDNRB	146	P24530
PIIISVFVLALYLHA	ADCY5	991	O95622
LYTLAVNSHPILLQI	DIPK2B	211	Q9H7Y0
LRHFLVQDTVYPLLA	DISP2	481	A7MBM2
PQHFQQYLLLLLPEV	ASXL3	276	Q9C0F0
IYPQLLLALLIQVHY	MROH7	861	Q68CQ1
ELYNIDSHLLLSVLP	PDS5B	261	Q9NTI5
LLSHFVEPVYLQSIV	ADARB2	571	Q9NS39
PIALQAIENAHVLLY	IREB2	731	P48200
EYELLVLPEAFTIHL	LARGE2	651	Q8N3Y3
AREDLLLPIYHQVAV	ACACB	2281	O00763
HILLANFYVVIPPAL	OR52E1	271	Q8NGJ3
RYIHILLANLYVVVP	OR52E2	271	Q8NGJ4
QLLAAVVEAFLYHVP	MUC4	5251	Q99102
IHSVLIFLVYFLIPL	NMBR	211	P28336
LLGLIIVYHAREIQL	KCNN2	181	Q9H2S1
IQYVHSLEDLEQLIP	ATCAY	296	Q86WG3
IFHEYNQTLTPVLLE	IPO11	416	Q9UI26
LNVPKLVLIYLQSHF	MIR17HG	21	Q75NE6
LHIIVQYNRPISDFL	FEM1B	536	Q9UK73
PYLLVHVDQELLIYE	CPSF1	861	Q10570
PGLEYLSQLDLIIIH	PLSCR5	56	A0PG75
IHFYLKTLQPQAILL	FAT2	3796	Q9NYQ8
PHLERILFVVILIAY	OR2W3	21	Q7Z3T1
LSYIQIFITVFHLPL	OR52A4P	221	A6NMU1
LYHPIQILADYLTLQ	OTC	166	P00480
EVLIQYHPRLFQTII	HACE1	246	Q8IYU2
VESLVPLYLHLSVNQ	MOSPD1	181	Q9UJG1
FKLIIPHLRYTLEIN	ALOX15	386	P16050
VYETQVPLLFRALVH	POLE	1426	Q07864
IFYLPIINLAVVHRF	OR51A2	251	Q8NGJ7
IFYLPIINLAVVHRF	OR51A4	251	Q8NGJ6
IPNHIHIIVANLYLL	OR52N2	271	Q8NGI0
PVHIHILLANVYLLL	OR52P1	271	Q8NH57
HYELLNYIDLPVLAI	DDX18	441	Q9NVP1
LHNEFDTIVLPVLYL	GPR87	36	Q9BY21
PHTEQLLFIVLLGVY	OR2D2	21	Q9H210
VPRVVHILFANLYLL	OR52R1	271	Q8NGF1
ILSAAPYHVIQLVNL	MCHR2	261	Q969V1
HVLQFLLLYQEPLLA	P2RX7	521	Q99572
QQVVLLLEDYQFVHP	DYNC2H1	2706	Q8NCM8
VLPYLIHDILLQDTN	ATM	1841	Q13315
VLPILEILYHVEERN	DYM	376	Q7RTS9
DKLPYELIQLILNHL	FBXL4	281	Q9UKA2
LIHAVIVLPLLYFLV	SLC1A3	326	P43003
QIIFVSVPTLLYLAH	GJA1	81	P17302
QLVIVLVPGALFHLY	GJE1	81	A6NN92
LPYHVAVLLDIFSIL	ACKR3	266	P25106
HLQEIFVPLVVRYVD	CADPS2	926	Q86UW7
LTILQLYHFLQIPTH	G6PC2	301	Q9NQR9
LVIPAHVRAQYVVLL	LEFTY2	51	O00292
ALVLRNIEPIVTLYH	KLB	181	Q86Z14
VVHEIQRYIDLLPTN	CYP2C18	351	P33260
VVLPLIDQYFKNHRL	RYR2	2966	Q92736
ILEVLHSLPAVRQYL	PSMD6	246	Q15008
IEYILLHAQEPILFI	MED6	66	O75586
LENIFLIPSHDIYLL	NUP210L	251	Q5VU65
IQLEASLHQPLYYLL	OR56A1	56	Q8NGH5
VSFLPLLLVLLSYVH	OR2AT4	211	A6NND4
IHILLANLYVVFPPA	OR52E5	271	Q8NH55
DIVPLHTQVLLADLY	OR52I1	271	Q8NGK6
HTQVLLADLYVIIPA	OR52I1	276	Q8NGK6
LHTQVLLADLYVIIP	OR52I2	301	Q8NH67
GYIHILVANLYLIIP	OR52J3	271	Q8NH60
LQSLPLTEIIRHYQL	STAT2	636	P52630
VIFHLQYINPDLLVD	TMCO5B	261	A8MYB1
ELHVYSLLILVVFLL	TEDDM1	126	Q5T9Z0
TLIFQHLLLYENPQD	FER1L5	1126	A0AVI2
FQIPRYIITLHELLA	RASGRF2	386	O14827
LIFQVRHTYEIPLVL	RIT2	116	Q99578
LQLLVLHIFPSIYDV	SLC35G2	361	Q8TBE7
LQEPLLVVAAFYILF	RPN1	436	P04843
GYVFLINLIPLHVLV	STT3A	211	P46977
LVLLFLLLLYVHSDP	SPATA31E1	76	Q6ZUB1
LPIHFVVLNQLYNFI	MED13	2156	Q9UHV7
PFYLIRLQLFKENIH	PIGC	266	Q92535
LALHLVNEFLYVLIV	URB1	1911	O60287
LQLDYVDLYLIHFPV	AKR1C1	106	Q04828
LQLDYVDLYLIHFPV	AKR1C2	106	P52895
HTINPILLYFIHFLI	ACSL3	16	O95573
IYEENLHYPLLLILT	CAMKMT	306	Q7Z624
IQLGKTVHYLPILFI	CLPTM1L	201	Q96KA5
PVSLYLLSQVFLIIH	CLEC16A	311	Q2KHT3
FRIGNLVLYILIIIH	CNGA3	301	Q16281
TSLPILIYSLLEQHV	ATP11B	921	Q9Y2G3
LPILAYSLLEQHINI	ATP11C	921	Q8NB49
VEILLDRITPYLLHF	PIK3R4	411	Q99570
LIQYFSPVIQDHLRL	SPG11	1391	Q96JI7
IFILLEPVLQHSQYL	TLR8	976	Q9NR97
LNAFYPLLVILHFIQ	UNC50	161	Q53HI1
PLLVILHFIQLFFIN	UNC50	166	Q53HI1
LEDVVLHLGIYPFLL	TTC8	211	Q8TAM2
YLIAHLPRLEQLILS	TBCE	271	Q15813
YVFIINLIPLHVFVL	STT3B	266	Q8TCJ2
ILHRYESLLLQVSEP	TRIM51	251	Q9BSJ1
LLHEPYVDLVNLLLT	STC2	166	O76061
IILPQHLYNIESEIE	UBE2O	701	Q9C0C9
IFIHLNDIYSVVGIP	THUMPD2	251	Q9BTF0
VLPQLRYLHIFLEQV	ZBED10P	16	Q96FA7
FNHKLPLLFQLIIDY	NRDC	766	O43847
AIIIHPNFILESYVN	TMPRSS12	156	Q86WS5
LLHLLFLYQPEAVQV	TMCO6	446	Q96DC7
LVRYHIVPFTQLEVA	STAB2	586	Q8WWQ8
VRYQLAISHLALIPE	ROS1	1591	P08922
FLHYIIPPTLNDVLI	TAAR1	276	Q96RJ0
YFPTLRHEILELIIE	RRN3P2	211	A6NIE6
LDLLDVLLPHAQTYV	USB1	96	Q9BQ65
IENLFYPVTLEVLHQ	PTBP3	186	O95758
VLYFLAHEDNLLPIQ	TAS1R2	111	Q8TE23
AILLLIFHLLPTYFV	TMEM245	776	Q9H330
LGYLDLLEHVLVILQ	TLN2	2246	Q9Y4G6
HLINYIIFLRITPFL	TMEM41B	196	Q5BJD5
ERNHPLFVVYLALQL	ZDHHC12	136	Q96GR4
ENLDILYFLLRVPHL	TLR5	436	O60602
IPVTIHNLEEYLRLV	TRIP12	1811	Q14669
PLVLHNGLIDLVFLY	TOE1	186	Q96GM8
ILLENVLKPLHFTYN	UBE3C	236	Q15386
IRDVLLPQYEHILLE	ULK4	986	Q96C45
EIEILLRYGQHPNII	RPS6KA2	456	Q15349