Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone modifying activity	KMT2D BRPF1 NSD3 KDM1B BRD1	4.26e-06	229	22	5	GO:0140993
GeneOntologyMolecularFunction	histone H4K8 acetyltransferase activity	BRPF1 BRD1	6.34e-05	11	22	2	GO:0043996
GeneOntologyMolecularFunction	histone H4K5 acetyltransferase activity	BRPF1 BRD1	6.34e-05	11	22	2	GO:0043995
GeneOntologyMolecularFunction	histone H4K12 acetyltransferase activity	BRPF1 BRD1	7.60e-05	12	22	2	GO:0043997
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2D NSD3	2.18e-04	20	22	2	GO:0042800
GeneOntologyMolecularFunction	histone H4 acetyltransferase activity	BRPF1 BRD1	2.89e-04	23	22	2	GO:0010485
GeneOntologyMolecularFunction	FAD binding	KDM1B CRY1	1.07e-03	44	22	2	GO:0071949
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2D NSD3	1.07e-03	44	22	2	GO:0140938
GeneOntologyMolecularFunction	acyltransferase activity	WDSUB1 BRPF1 RNF113A FBXL5 BRD1	1.32e-03	775	22	5	GO:0016746
GeneOntologyMolecularFunction	histone acetyltransferase activity	BRPF1 BRD1	1.43e-03	51	22	2	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	BRPF1 BRD1	1.66e-03	55	22	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	BRPF1 BRD1	1.97e-03	60	22	2	GO:0034212
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2D NSD3	2.53e-03	68	22	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2D NSD3	2.60e-03	69	22	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2D NSD3	2.75e-03	71	22	2	GO:0042054
GeneOntologyMolecularFunction	N-acetyltransferase activity	BRPF1 BRD1	3.31e-03	78	22	2	GO:0008080
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	KDM1B CRY1	4.76e-03	94	22	2	GO:0050660
GeneOntologyMolecularFunction	N-acyltransferase activity	BRPF1 BRD1	5.58e-03	102	22	2	GO:0016410
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2D NSD3	5.69e-03	103	22	2	GO:0008276
GeneOntologyMolecularFunction	acetyltransferase activity	BRPF1 BRD1	5.80e-03	104	22	2	GO:0016407
GeneOntologyMolecularFunction	N-methyltransferase activity	KMT2D NSD3	5.91e-03	105	22	2	GO:0008170
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	WDSUB1 RNF113A FBXL5	1.46e-02	473	22	3	GO:0004842
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	KMT2D NSD3	1.52e-02	172	22	2	GO:0008757
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	WDSUB1 RNF113A FBXL5	1.80e-02	512	22	3	GO:0019787
GeneOntologyMolecularFunction	extracellular matrix structural constituent	LAMA3 LAMB3	1.80e-02	188	22	2	GO:0005201
GeneOntologyMolecularFunction	aminoacyltransferase activity	WDSUB1 RNF113A FBXL5	1.99e-02	532	22	3	GO:0016755
GeneOntologyBiologicalProcess	positive regulation of integrin-mediated signaling pathway	PCSK5 LIMS2	1.07e-04	14	23	2	GO:2001046
GeneOntologyCellularComponent	laminin-5 complex	LAMA3 LAMB3	6.94e-06	4	23	2	GO:0005610
GeneOntologyCellularComponent	MOZ/MORF histone acetyltransferase complex	BRPF1 BRD1	2.42e-05	7	23	2	GO:0070776
GeneOntologyCellularComponent	H3 histone acetyltransferase complex	BRPF1 BRD1	3.23e-05	8	23	2	GO:0070775
GeneOntologyCellularComponent	laminin complex	LAMA3 LAMB3	5.18e-05	10	23	2	GO:0043256
HumanPheno	Duplicated collecting system	LAMA3 LAMB3 KMT2D	1.97e-05	24	12	3	HP:0000081
HumanPheno	Abnormal renal collecting system morphology	LAMA3 LAMB3 KMT2D	3.91e-05	30	12	3	HP:0004742
HumanPheno	Renal necrosis	LAMA3 LAMB3	5.07e-05	5	12	2	HP:0032618
HumanPheno	Pyoderma	LAMA3 LAMB3	5.07e-05	5	12	2	HP:0000999
HumanPheno	Renal tubular epithelial necrosis	LAMA3 LAMB3	5.07e-05	5	12	2	HP:0008682
HumanPheno	Ureteral obstruction	LAMA3 LAMB3 KMT2D	8.71e-05	39	12	3	HP:0006000
HumanPheno	Hypoplastic dermoepidermal hemidesmosomes	LAMA3 LAMB3	1.06e-04	7	12	2	HP:0020117
HumanPheno	Alopecia of scalp	LAMA3 LAMB3 RNF113A	1.34e-04	45	12	3	HP:0002293
HumanPheno	Mitten deformity	LAMA3 LAMB3	1.81e-04	9	12	2	HP:0004057
HumanPheno	Congenital localized absence of skin	LAMA3 LAMB3	1.81e-04	9	12	2	HP:0007383
HumanPheno	Abnormal dermatological laboratory findings	LAMA3 LAMB3	2.27e-04	10	12	2	HP:0003340
HumanPheno	Lamina lucida cleavage	LAMA3 LAMB3	2.27e-04	10	12	2	HP:0003341
HumanPheno	Subepidermal blistering	LAMA3 LAMB3	2.77e-04	11	12	2	HP:0033804
HumanPheno	Abnormal dermoepidermal hemidesmosome morphology	LAMA3 LAMB3	2.77e-04	11	12	2	HP:0032449
HumanPheno	Abnormal dermoepidermal junction morphology	LAMA3 LAMB3	3.31e-04	12	12	2	HP:0031538
HumanPheno	Nail dystrophy	LAMA3 LAMB3 KMT2D RNF113A	3.46e-04	156	12	4	HP:0008404
HumanPheno	Blistering by histological location	LAMA3 LAMB3	3.91e-04	13	12	2	HP:0033801
HumanPheno	Decreased circulating IgG subclass concentration	KMT2D RNF113A	3.91e-04	13	12	2	HP:0032135
HumanPheno	Ureteral duplication	LAMA3 LAMB3 KMT2D	4.40e-04	67	12	3	HP:0000073
HumanPheno	Oral mucosal blisters	LAMA3 LAMB3	4.56e-04	14	12	2	HP:0200097
HumanPheno	Renal duplication	LAMA3 LAMB3 KMT2D	4.80e-04	69	12	3	HP:0000075
HumanPheno	Abdominal organ duplication	LAMA3 LAMB3 KMT2D	4.80e-04	69	12	3	HP:0005217
HumanPheno	Squamous cell carcinoma	LAMA3 LAMB3 RNF113A	5.22e-04	71	12	3	HP:0002860
HumanPheno	Carious teeth	LAMA3 LAMB3 KMT2D RNF113A	5.25e-04	174	12	4	HP:0000670
HumanPheno	Hoarse cry	LAMA3 LAMB3	5.25e-04	15	12	2	HP:0001615
HumanPheno	Aplasia/Hypoplasia of the bladder	LAMA3 LAMB3	5.99e-04	16	12	2	HP:0010476
HumanPheno	Scarring alopecia of scalp	LAMA3 LAMB3	5.99e-04	16	12	2	HP:0004552
HumanPheno	Laryngeal stenosis	LAMA3 LAMB3	5.99e-04	16	12	2	HP:0001602
HumanPheno	Paronychia	LAMA3 LAMB3	5.99e-04	16	12	2	HP:0001818
HumanPheno	Urethral stricture	LAMA3 LAMB3	6.78e-04	17	12	2	HP:0012227
HumanPheno	Milia	LAMA3 LAMB3	6.78e-04	17	12	2	HP:0001056
HumanPheno	Dysuria	LAMA3 LAMB3	7.62e-04	18	12	2	HP:0100518
HumanPheno	Abnormal fingertip morphology	LAMA3 LAMB3 KMT2D RNF113A	9.42e-04	203	12	4	HP:0001211
HumanPheno	Esophageal stricture	LAMA3 LAMB3	9.44e-04	20	12	2	HP:0002043
HumanPheno	Unexplained fevers	LAMA3 LAMB3	9.44e-04	20	12	2	HP:0001955
HumanPheno	Abnormality of the periungual region	LAMA3 LAMB3	1.14e-03	22	12	2	HP:0100803
HumanPheno	Multicystic kidney dysplasia	LAMA3 LAMB3 KMT2D	1.34e-03	98	12	3	HP:0000003
HumanPheno	Enamel hypoplasia	LAMA3 LAMB3 RNF113A	1.59e-03	104	12	3	HP:0006297
HumanPheno	Blistering by anatomical location	LAMA3 LAMB3	1.60e-03	26	12	2	HP:0033800
Domain	PWWP	BRPF1 NSD3 BRD1	1.60e-06	20	22	3	SM00293
Domain	Znf_PHD-finger	KMT2D BRPF1 NSD3 BRD1	2.05e-06	79	22	4	IPR019787
Domain	EPHD	KMT2D BRPF1 BRD1	2.15e-06	22	22	3	PS51805
Domain	PWWP	BRPF1 NSD3 BRD1	2.47e-06	23	22	3	PF00855
Domain	PWWP_dom	BRPF1 NSD3 BRD1	2.47e-06	23	22	3	IPR000313
Domain	PWWP	BRPF1 NSD3 BRD1	2.83e-06	24	22	3	PS50812
Domain	PHD	KMT2D BRPF1 NSD3 BRD1	3.30e-06	89	22	4	SM00249
Domain	Znf_PHD	KMT2D BRPF1 NSD3 BRD1	3.61e-06	91	22	4	IPR001965
Domain	ZF_PHD_2	KMT2D BRPF1 NSD3 BRD1	4.28e-06	95	22	4	PS50016
Domain	ZF_PHD_1	KMT2D BRPF1 NSD3 BRD1	4.47e-06	96	22	4	PS01359
Domain	-	WDSUB1 KMT2D BRPF1 NSD3 RNF113A BRD1	1.00e-05	449	22	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	WDSUB1 KMT2D BRPF1 NSD3 RNF113A BRD1	1.14e-05	459	22	6	IPR013083
Domain	Znf_FYVE_PHD	KMT2D BRPF1 NSD3 BRD1	2.41e-05	147	22	4	IPR011011
Domain	Enhancer_polycomb-like_N	BRPF1 BRD1	3.69e-05	8	22	2	IPR019542
Domain	EPL1	BRPF1 BRD1	3.69e-05	8	22	2	PF10513
Domain	Zinc_finger_PHD-type_CS	BRPF1 NSD3 BRD1	5.91e-05	65	22	3	IPR019786
Domain	PHD	KMT2D NSD3 BRD1	9.07e-05	75	22	3	PF00628
Domain	LAMININ_NTER	LAMA3 LAMB3	1.57e-04	16	22	2	PS51117
Domain	Laminin_N	LAMA3 LAMB3	1.57e-04	16	22	2	PF00055
Domain	Post-SET_dom	KMT2D NSD3	1.57e-04	16	22	2	IPR003616
Domain	PostSET	KMT2D NSD3	1.57e-04	16	22	2	SM00508
Domain	Laminin_N	LAMA3 LAMB3	1.57e-04	16	22	2	IPR008211
Domain	POST_SET	KMT2D NSD3	1.57e-04	16	22	2	PS50868
Domain	LamNT	LAMA3 LAMB3	1.57e-04	16	22	2	SM00136
Domain	Bromodomain_CS	BRPF1 BRD1	4.23e-04	26	22	2	IPR018359
Domain	EGF_LAM_2	LAMA3 LAMB3	5.65e-04	30	22	2	PS50027
Domain	EGF_LAM_1	LAMA3 LAMB3	5.65e-04	30	22	2	PS01248
Domain	Laminin_EGF	LAMA3 LAMB3	7.70e-04	35	22	2	PF00053
Domain	EGF_Lam	LAMA3 LAMB3	7.70e-04	35	22	2	SM00180
Domain	BROMODOMAIN_1	BRPF1 BRD1	8.60e-04	37	22	2	PS00633
Domain	Laminin_EGF	LAMA3 LAMB3	9.08e-04	38	22	2	IPR002049
Domain	Bromodomain	BRPF1 BRD1	9.08e-04	38	22	2	PF00439
Domain	BROMODOMAIN_2	BRPF1 BRD1	1.06e-03	41	22	2	PS50014
Domain	SET	KMT2D NSD3	1.06e-03	41	22	2	PF00856
Domain	BROMO	BRPF1 BRD1	1.11e-03	42	22	2	SM00297
Domain	Bromodomain	BRPF1 BRD1	1.11e-03	42	22	2	IPR001487
Domain	-	BRPF1 BRD1	1.11e-03	42	22	2	1.20.920.10
Domain	SET	KMT2D NSD3	1.33e-03	46	22	2	SM00317
Domain	SET_dom	KMT2D NSD3	1.57e-03	50	22	2	IPR001214
Domain	SET	KMT2D NSD3	1.57e-03	50	22	2	PS50280
Domain	EGF-like_dom	PCSK5 LAMA3 C7	2.99e-03	249	22	3	IPR000742
Domain	EGF_1	LAMA3 LAMB3 C7	3.20e-03	255	22	3	PS00022
Domain	EGF-like_CS	LAMA3 LAMB3 C7	3.41e-03	261	22	3	IPR013032
Domain	EGF_2	LAMA3 LAMB3 C7	3.56e-03	265	22	3	PS01186
Domain	RING	KMT2D NSD3 RNF113A	5.28e-03	305	22	3	SM00184
Domain	Galactose-bd-like	PCSK5 LAMB3	5.42e-03	94	22	2	IPR008979
Domain	Znf_RING	KMT2D NSD3 RNF113A	6.34e-03	326	22	3	IPR001841
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2D BRPF1 NSD3 KDM1B BRD1	7.56e-07	175	15	5	MM14941
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2D BRPF1 NSD3 KDM1B BRD1	6.61e-06	272	15	5	M29619
Pathway	PID_INTEGRIN4_PATHWAY	LAMA3 LAMB3	5.78e-05	11	15	2	M158
Pathway	REACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY	LAMA3 LAMB3	5.78e-05	11	15	2	M27372
Pathway	REACTOME_SIGNALING_BY_MET	LAMA3 LAMB3 RPS27A	7.34e-05	79	15	3	M27643
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	LAMA3 LAMB3	1.10e-04	15	15	2	M27161
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	LAMA3 LAMB3 LIMS2	2.36e-04	117	15	3	M19248
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	BRPF1 BRD1	4.22e-04	29	15	2	MM15340
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	LAMA3 LAMB3	4.52e-04	30	15	2	M27772
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	BRPF1 BRD1	4.52e-04	30	15	2	M27637
Pathway	REACTOME_LAMININ_INTERACTIONS	LAMA3 LAMB3	4.52e-04	30	15	2	M27216
Pathway	REACTOME_CELL_CELL_COMMUNICATION	LAMA3 LAMB3 LIMS2	5.38e-04	155	15	3	M522
Pathway	WP_ALPHA_6_BETA_4_SIGNALING	LAMA3 LAMB3	5.47e-04	33	15	2	M39503
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	BRPF1 RPS27A BRD1	5.59e-04	157	15	3	MM15226
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	BRPF1 RPS27A BRD1	5.91e-04	160	15	3	M27498
Pathway	REACTOME_MET_PROMOTES_CELL_MOTILITY	LAMA3 LAMB3	8.46e-04	41	15	2	M27778
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	KMT2D RPS27A	8.88e-04	42	15	2	M27272
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2D NSD3	1.06e-03	46	15	2	MM14933
Pathway	REACTOME_HATS_ACETYLATE_HISTONES	BRPF1 BRD1	1.06e-03	46	15	2	MM14935
Pathway	PID_A6B1_A6B4_INTEGRIN_PATHWAY	LAMA3 LAMB3	1.06e-03	46	15	2	M239
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	PCSK5 LAMA3 ZNF142	3.33e-07	21	23	3	22959728
Pubmed	Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.	BRPF1 BRD1	4.18e-07	2	23	2	24333487
Pubmed	Structural requirement for cell adhesion to kalinin (laminin-5).	LAMA3 LAMB3	4.18e-07	2	23	2	7775432
Pubmed	A recurrent laminin 5 mutation in British patients with lethal (Herlitz) junctional epidermolysis bullosa: evidence for a mutational hotspot rather than propagation of an ancestral allele.	LAMA3 LAMB3	4.18e-07	2	23	2	9205497
Pubmed	Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics.	LAMA3 LAMB3	1.25e-06	3	23	2	16179086
Pubmed	Laminin-5 mutational analysis in an Italian cohort of patients with junctional epidermolysis bullosa.	LAMA3 LAMB3	1.25e-06	3	23	2	15373767
Pubmed	Herlitz junctional epidermolysis bullosa keratinocytes display heterogeneous defects of nicein/kalinin gene expression.	LAMA3 LAMB3	1.25e-06	3	23	2	8113417
Pubmed	Laminin-5 activates extracellular matrix production and osteogenic gene focusing in human mesenchymal stem cells.	LAMA3 LAMB3	1.25e-06	3	23	2	17137774
Pubmed	Assignment of mouse nicein genes to chromosomes 1 and 18.	LAMA3 LAMB3	1.25e-06	3	23	2	8012114
Pubmed	Passive transfer of anti-laminin 5 antibodies induces subepidermal blisters in neonatal mice.	LAMA3 LAMB3	1.25e-06	3	23	2	8833897
Pubmed	Expression and chain assembly of human laminin-332 in an insect cell-free translation system.	LAMA3 LAMB3	1.25e-06	3	23	2	18603785
Pubmed	Genotype, Clinical Course, and Therapeutic Decision Making in 76 Infants with Severe Generalized Junctional Epidermolysis Bullosa.	LAMA3 LAMB3	1.25e-06	3	23	2	27375110
Pubmed	Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.	LAMA3 LAMB3	1.25e-06	3	23	2	16165127
Pubmed	Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.	BRPF1 BRD1	1.25e-06	3	23	2	20400950
Pubmed	Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma.	LAMA3 LAMB3	1.25e-06	3	23	2	33179081
Pubmed	Synthetic D-amino acid peptide inhibits tumor cell motility on laminin-5.	LAMA3 LAMB3	1.25e-06	3	23	2	16537560
Pubmed	Fibroblasts contribute to the deposition of laminin 5 in the extracellular matrix.	LAMA3 LAMB3	1.25e-06	3	23	2	15149852
Pubmed	Quantitative analysis of laminin 5 gene expression in human keratinocytes.	LAMA3 LAMB3	1.25e-06	3	23	2	15854126
Pubmed	Differential expression of laminin-5 subunits during incisor and molar development in the mouse.	LAMA3 LAMB3	1.25e-06	3	23	2	10853832
Pubmed	Developmental expression of laminin-5 and HD1 in the intestine: epithelial to mesenchymal shift for the laminin gamma-2 chain subunit deposition.	LAMA3 LAMB3	1.25e-06	3	23	2	9019243
Pubmed	Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration.	LAMA3 LAMB3	1.25e-06	3	23	2	22563463
Pubmed	Laminin-332 (Laminin-5) is the major motility ligand for B cell chronic lymphocytic leukemia.	LAMA3 LAMB3	1.25e-06	3	23	2	17482449
Pubmed	Localization of laminin-5, HD1/plectin, and BP230 in the submandibular glands of developing and adult mice.	LAMA3 LAMB3	2.51e-06	4	23	2	10651091
Pubmed	Invasive breast cancer induces laminin-332 upregulation and integrin β4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype during tissue remodeling.	LAMA3 LAMB3	2.51e-06	4	23	2	22673183
Pubmed	Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332.	LAMA3 LAMB3	2.51e-06	4	23	2	21034821
Pubmed	Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility.	LAMA3 LAMB3	2.51e-06	4	23	2	19940114
Pubmed	Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain.	LAMA3 LAMB3	2.51e-06	4	23	2	10806203
Pubmed	The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.	BRPF1 BRD1	2.51e-06	4	23	2	26677226
Pubmed	Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.	BRPF1 BRD1	2.51e-06	4	23	2	24258712
Pubmed	Developmental expression of nicein adhesion protein (laminin-5) subunits suggests multiple morphogenic roles.	LAMA3 LAMB3	2.51e-06	4	23	2	8081888
Pubmed	Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.	BRPF1 BRD1	2.51e-06	4	23	2	24065767
Pubmed	Recombinant human laminin-5 domains. Effects of heterotrimerization, proteolytic processing, and N-glycosylation on alpha3beta1 integrin binding.	LAMA3 LAMB3	4.18e-06	5	23	2	14612440
Pubmed	IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa.	LAMA3 LAMB3	4.18e-06	5	23	2	9271670
Pubmed	Expression of type XXIII collagen mRNA and protein.	LAMA3 LAMB3	4.18e-06	5	23	2	16728390
Pubmed	Laminin 5 regulates polycystic kidney cell proliferation and cyst formation.	LAMA3 LAMB3	4.18e-06	5	23	2	16870608
Pubmed	Expression and localization of laminin-5 subunits in the mouse incisor.	LAMA3 LAMB3	6.26e-06	6	23	2	9506922
Pubmed	Junctional Epidermolysis Bullosa	LAMA3 LAMB3	6.26e-06	6	23	2	20301304
Pubmed	Structural and histone binding ability characterizations of human PWWP domains.	BRPF1 BRD1	6.26e-06	6	23	2	21720545
Pubmed	Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor.	LAMA3 LAMB3	8.77e-06	7	23	2	9004048
Pubmed	Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.	NSD3 KDM1B	8.77e-06	7	23	2	20670891
Pubmed	Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.	BRPF1 BRD1	8.77e-06	7	23	2	18794358
Pubmed	Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis.	LAMA3 LAMB3	1.17e-05	8	23	2	23529140
Pubmed	Expression and localization of laminin-5 subunits during mouse tooth development.	LAMA3 LAMB3	1.17e-05	8	23	2	9489770
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	LAMA3 LAMB3	1.50e-05	9	23	2	12482924
Pubmed	Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons.	LAMA3 LAMB3	1.88e-05	10	23	2	9034910
Pubmed	The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.	LAMA3 LAMB3	2.29e-05	11	23	2	10811835
Pubmed	Current insights into the formation and breakdown of hemidesmosomes.	LAMA3 LAMB3	2.29e-05	11	23	2	16757171
Pubmed	Regional differences in the expression of laminin isoforms during mouse neural tube development.	LAMA3 LAMB3	2.29e-05	11	23	2	21524702
Pubmed	Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.	LAMA3 LAMB3	2.29e-05	11	23	2	8707838
Pubmed	Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.	LAMA3 LAMB3	2.75e-05	12	23	2	9396756
Pubmed	Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.	LAMA3 LAMB3	4.37e-05	15	23	2	9264260
Pubmed	Basement membrane composition in the early mouse embryo day 7.	LAMA3 LAMB3	4.37e-05	15	23	2	15895400
Pubmed	Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.	PCSK5 LAMB3 C7	4.53e-05	105	23	3	24667918
Pubmed	Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.	LAMA3 LAMB3	4.99e-05	16	23	2	12533516
Pubmed	Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.	LAMA3 LAMB3	4.99e-05	16	23	2	17601529
Pubmed	Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.	LAMA3 LAMB3	6.36e-05	18	23	2	11311202
Pubmed	Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.	LAMA3 LAMB3	7.89e-05	20	23	2	22911573
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2D KDM1B	7.89e-05	20	23	2	29785026
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2D KDM1B	8.72e-05	21	23	2	27626377
Pubmed	KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.	BRPF1 BRD1	8.72e-05	21	23	2	27270040
Pubmed	Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.	BRPF1 BRD1	8.72e-05	21	23	2	25281266
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	LAMA3 LAMB3	8.72e-05	21	23	2	27856617
Pubmed	Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.	LAMA3 LAMB3	1.35e-04	26	23	2	24742657
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KMT2D BRPF1 KDM1B	1.50e-04	157	23	3	30186101
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	LAMA3 LAMB3	1.68e-04	29	23	2	22613833
Pubmed	Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.	LAMA3 LAMB3	2.05e-04	32	23	2	23154389
Pubmed	Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin.	LAMA3 LAMB3	2.90e-04	38	23	2	27653694
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	PCSK5 ZNF142 ZFAT	2.96e-04	198	23	3	20881960
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	LAMA3 LAMB3	3.21e-04	40	23	2	27068110
Pubmed	The chromatin regulator Brpf1 regulates embryo development and cell proliferation.	BRPF1 BRD1	3.21e-04	40	23	2	25773539
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	BRPF1 BRD1	3.54e-04	42	23	2	16387653
Pubmed	Functional proteomics mapping of a human signaling pathway.	KMT2D RPS27A BRD1 LIMS2	5.65e-04	591	23	4	15231748
Pubmed	Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.	RPS27A RNF113A	6.08e-04	55	23	2	31985874
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BRPF1 NSD3 KDM1B BRD1	6.29e-04	608	23	4	36089195
Cytoband	5q35.3	FAM193B ZNF879	1.04e-03	95	23	2	5q35.3
Cytoband	Ensembl 112 genes in cytogenetic band chr5q35	FAM193B ZNF879	6.15e-03	235	23	2	chr5q35
GeneFamily	PWWP domain containing	BRPF1 NSD3 BRD1	1.26e-06	22	18	3	1147
GeneFamily	PHD finger proteins	KMT2D BRPF1 NSD3 BRD1	1.67e-06	90	18	4	88
GeneFamily	Laminin subunits	LAMA3 LAMB3	6.14e-05	12	18	2	626
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D NSD3	5.15e-04	34	18	2	487
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF879 ZNF142 ZFAT	3.26e-02	718	18	3	28
ToppCell	E17.5-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BRPF1 NSD3 KDM1B	6.13e-05	150	23	3	201d5b68e71c6c003285428be96c488e6d526edf
ToppCell	AT1_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	LAMA3 LAMB3 LIMS2	9.35e-05	173	23	3	b29816427428c7053017477f59b828bf1357f3b2
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	FAM193B BRPF1 ZFAT	1.02e-04	178	23	3	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	COPD-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	SHROOM4 C7 LIMS2	1.03e-04	179	23	3	9968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA3 LAMB3 ZFAT	1.03e-04	179	23	3	88dbec952507d84b85b08165eec80df99ed1e736
ToppCell	facs-Lung-EPCAM-3m-Epithelial-type_I_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA3 LAMB3 ZFAT	1.03e-04	179	23	3	daf8189a22786171e2b629261cf720736aa4ebdb
ToppCell	control-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NSD3 RPS27A SHISAL2A	1.05e-04	180	23	3	592fb72cc344efff1bd3376d9f28c79745c61469
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GGN FAM221A ZNF879	1.07e-04	181	23	3	ebf1ae963a2b22e1772752ed85a4fb0e546d377e
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 SHROOM4 LAMA3	1.09e-04	182	23	3	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 SHROOM4 LAMA3	1.09e-04	182	23	3	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SHROOM4 C7 LIMS2	1.10e-04	183	23	3	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	SHROOM4 C7 LIMS2	1.10e-04	183	23	3	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	COPD-Endothelial-VE_Venous\|COPD / Disease state, Lineage and Cell class	SHROOM4 C7 LIMS2	1.12e-04	184	23	3	44d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ZNF879 KMT2D ZFAT	1.14e-04	185	23	3	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	367C-Endothelial_cells-Endothelial-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM4 C7 LIMS2	1.18e-04	187	23	3	1342bc614bc4045263c2eb0a535a1dd6c64e7abe
ToppCell	367C-Endothelial_cells-Endothelial-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM4 C7 LIMS2	1.18e-04	187	23	3	7aa206262b14b9f2aaa99e59da38b96c3594d2c9
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Tumor_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	SHROOM4 C7 LIMS2	1.18e-04	187	23	3	2713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCell	Endothelial-A-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	SHROOM4 C7 LIMS2	1.18e-04	187	23	3	febe0b99a6a815ce687160a0e7af55228b1d5beb
ToppCell	Endothelial-A-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SHROOM4 C7 LIMS2	1.20e-04	188	23	3	0824d567356d360fd8e78e840c30529c139f98a1
ToppCell	ASK454-Epithelial-Type_1\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	LAMA3 LAMB3 LIMS2	1.20e-04	188	23	3	13f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA3 LAMB3 FAM221A	1.21e-04	189	23	3	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 LAMA3 LIMS2	1.21e-04	189	23	3	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 SHROOM4 LIMS2	1.21e-04	189	23	3	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	Control-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	SHROOM4 C7 LIMS2	1.21e-04	189	23	3	f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SHROOM4 C7 LIMS2	1.23e-04	190	23	3	ac2eb1e51459d187095152e0cd41ae54c1025c6f
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	SHROOM4 C7 LIMS2	1.23e-04	190	23	3	6010f16378f2d9cde37c7e7db6a7d9666edaddcc
ToppCell	Control-Endothelial-VE_Venous\|Control / Disease state, Lineage and Cell class	SHROOM4 C7 LIMS2	1.25e-04	191	23	3	617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCSK5 SHROOM4 LIMS2	1.25e-04	191	23	3	04c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCSK5 SHROOM4 LIMS2	1.25e-04	191	23	3	db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA3 LAMB3 FAM221A	1.27e-04	192	23	3	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 LAMA3 LIMS2	1.27e-04	192	23	3	56b021c297a21dff357531f21e2464f85186106d
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.29e-04	193	23	3	c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCell	IPF-Endothelial-VE_Venous\|IPF / Disease state, Lineage and Cell class	SHROOM4 C7 LIMS2	1.29e-04	193	23	3	29a655fa80feaabe846c90a28363b037e22d24ae
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.29e-04	193	23	3	682ce63b73a7d02eef240673db67058d7507f744
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM4 C7 LIMS2	1.29e-04	193	23	3	9ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCell	IPF-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	SHROOM4 C7 LIMS2	1.29e-04	193	23	3	ef66a46e7ab44fcc4005a23416e6da478a4cce37
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 LAMA3 LIMS2	1.33e-04	195	23	3	6bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.33e-04	195	23	3	53b83e16b350100b1d5791a9c42bd98e37cbc0af
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 SHROOM4 LIMS2	1.33e-04	195	23	3	b0979c1b5e4576468b8fe4e9027650859e598b34
ToppCell	Epithelial_cells-AT1_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	LAMA3 LAMB3 LIMS2	1.35e-04	196	23	3	6c99d29162848161c1f166a032320f87a5d5a631
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LAMA3 LAMB3 LIMS2	1.37e-04	197	23	3	f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCell	normal_Lung-Epithelial_cells-AT1\|Epithelial_cells / Location, Cell class and cell subclass	LAMA3 LAMB3 LIMS2	1.37e-04	197	23	3	7d19b93d6853828e2a036e37c4887edb1de4503c
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.37e-04	197	23	3	8437c33e2c4a10a1b95343431e48d5e820b1f742
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.37e-04	197	23	3	0542badae77d2f606c13cfaf361319495c354351
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.37e-04	197	23	3	a6a64581699cfcb9607b288976fa3b09648725b7
ToppCell	distal-1-Endothelial-Vein\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SHROOM4 C7 LIMS2	1.39e-04	198	23	3	eee6cb4fe0e1caf460869d5a0a57c9d259573f10
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 SHROOM4 LIMS2	1.39e-04	198	23	3	5e781583908c4ee107d986904a646a7c6b8e3591
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.39e-04	198	23	3	fb70a649e4e2edb32967328c1085dc5999c29a33
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PCSK5 LAMA3 LAMB3	1.39e-04	198	23	3	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Epithelial_cells-AT1-AT2_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	LAMA3 LAMB3 LIMS2	1.39e-04	198	23	3	fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.39e-04	198	23	3	71ee440b1ac566db63d0b415c50a0ad064d14f15
ToppCell	IIH-CD4-naive_CD4\|IIH / Condition, Cell_class and T cell subcluster	NSD3 RPS27A LIMS2	1.39e-04	198	23	3	85414b283bbcdbf3393ab1b4302ef0e21c7a8181
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 C7 LIMS2	1.39e-04	198	23	3	3ae1e2b4ca77b94eaa24a8c990780aff47dface6
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	53b6a661d381b1ed3ea96e61e8bd1750de7d9fda
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	LAMA3 LAMB3 FAM221A	1.41e-04	199	23	3	af664e0d41a889a75dbf6cf0d50acd26f5ab3a3a
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PCSK5 LAMA3 LAMB3	1.41e-04	199	23	3	94a7867e800df352731796de8c24cba133c29622
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	9c753043024871b1f1436fc39defac4da85e10cd
ToppCell	Endothelial_cells-Endothelial-A\|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	2a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-2_Progenitor\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	LAMA3 LAMB3 RPS27A	1.41e-04	199	23	3	180b3997174fd63bdf3b828063a13483eb4cab29
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Endothelial-2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	523e01f6a0abd9820697572e042a381aae8932dc
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	d017dd91f9b10038f1f83753a766e534da2dbe89
ToppCell	(5)_Epi_suprabasal\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	LAMA3 LAMB3 RPS27A	1.41e-04	199	23	3	e1d0fd71b2f3925d02638413f2155db009f103d9
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	0d0d5cb821db16514192ad536849a8a04e22e637
ToppCell	cellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	68412bc39639edc4045437d62548f7101b9f1989
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	LAMA3 LAMB3 RPS27A	1.41e-04	199	23	3	bb2e839197b9a44b632c1bb716e48d885a1c8713
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SHROOM4 C7 LIMS2	1.41e-04	199	23	3	dfd60380a29f99e187050933ee5252ec11c68a32
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	84e145619a500530f42ed0fe72468ae95f4cbf1e
ToppCell	normal_Lung-Endothelial_cells-Stalk-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	RPS27A C7 LIMS2	1.44e-04	200	23	3	413ac64bbe95b8c921c5396d8b5f298fec8c4f82
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	cb00760ae75c30b1cb8526534aabd4ffc7c21000
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	c55efd997392e99068b673542f56f1a209c5a6c8
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Endothelial-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	b65fb8d378abd91cdabf5faac5f4b90d527f8c44
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	2cb6e35add34b9dc564ebcf5d3cbc761325ca9f4
ToppCell	distal-Endothelial-Vein\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	6acf7afe122f81a95c4c66f4d0878d997b57127a
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Bronchial_vessel\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	a18817d36b2b30a32e1513d36174bf98dfea2a92
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	LAMA3 LAMB3 FAM221A	1.44e-04	200	23	3	eac33be484dc443794e66e473f03e98406c2983e
ToppCell	Biopsy_Control_(H.)-Endothelial-Endothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	0242d465da2dfba0da629a43e152949c5192465b
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	71979bbcc035d5b8882f1502b5a8ef248aaba45a
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SHROOM4 C7 LIMS2	1.44e-04	200	23	3	27507c4b41d45c7cc50e4993169c0302be22ee34
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PCSK5 SHISAL2A	9.96e-04	91	23	2	3f56358ff0dacdf6b8fc22cea64082231bceb851
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM4 FAM193B	1.22e-03	101	23	2	86acaa2502f61baa714ae988b73e3e73a71e897e
ToppCell	Mild/Remission-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NSD3 SHISAL2A	1.75e-03	121	23	2	68940a552233d255b90ce5a081339c0d9d46ab02
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-Uncommitted_AE_Progenitor\|E18.5-samps / Age Group, Lineage, Cell class and subclass	LAMA3 ZFAT	1.81e-03	123	23	2	5f002f5180fe47fe57ab888b5f0319df99ab2c59
ToppCell	control-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS27A SHISAL2A	1.86e-03	125	23	2	30f593fadbe850cedd622711005f9069ad57cc03
ToppCell	ileum-Epithelial_Stem_Cells\|ileum / shred on tissue and cell subclass	SHROOM4 FAM221A	1.89e-03	126	23	2	a8ed48cbd1e207fd1aaad454fda9f329eb22aa83
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PCSK5 C7	1.89e-03	126	23	2	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	Control-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 FAM221A	1.92e-03	127	23	2	556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 LAMB3	2.01e-03	130	23	2	6434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NSD3 SHISAL2A	2.04e-03	131	23	2	a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Thalamus / BrainAtlas - Mouse McCarroll V32	SHROOM4 LAMA3	2.11e-03	133	23	2	29b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PCSK5 C7	2.14e-03	134	23	2	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	NS-moderate-d_07-13-Epithelial-IRC-IFNG_responsive_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LAMA3 LAMB3	2.20e-03	136	23	2	7f1ca43e0d164b511120316d4218d80ba21a9b5c
ToppCell	AT1-AT2_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	LAMA3 ZFAT	2.33e-03	140	23	2	45d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac\|Myeloid_cells / Location, Cell class and cell subclass	LIMS2 CRY1	2.36e-03	141	23	2	399380de5ea09e22fd128e3e55fffeffc4874c15
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ZNF879 ZFAT	2.40e-03	142	23	2	671ba8869db7a6dc69fd1caf0e561f15a312b170
ToppCell	Control-Epithelial_alveolar-AT_1-AT2_Progenitor\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 LAMB3	2.40e-03	142	23	2	94e277f038f4006d99ff50222b0f5cf89bc3d46d
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ZNF879 ZFAT	2.40e-03	142	23	2	3557084150670fd2e2634fc674f228ab85181b59
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ZNF879 ZFAT	2.40e-03	142	23	2	6a656d28c9f5dfb03a3a2d908cf2edbe0a5b1206
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ZNF879 ZFAT	2.40e-03	142	23	2	a3d1f4b570b75402171e38c5a7c88e2896520c8f
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NSD3 SHISAL2A	2.43e-03	143	23	2	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB3 C7	2.46e-03	144	23	2	1b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
Computational	Neighborhood of CDH3	LAMA3 LAMB3	2.70e-04	27	10	2	GNF2_CDH3
Computational	Neighborhood of SERPINB5	LAMA3 LAMB3	2.91e-04	28	10	2	GNF2_SERPINB5
Computational	Genes in the cancer module 153.	LAMA3 LAMB3	4.30e-04	34	10	2	MODULE_153
Computational	Genes upregulated in subsets of cells of a given type within various tumors	LAMA3 LAMB3	9.32e-04	50	10	2	GAVISH_3CA_MALIGNANT_METAPROGRAM_13_EMT_2
Computational	Genes in the cancer module 297.	LAMA3 LAMB3	2.37e-03	80	10	2	MODULE_297
Computational	Intermediate filaments and keratins.	LAMA3 LAMB3	2.37e-03	80	10	2	MODULE_357
Disease	lung small cell carcinoma (is_implicated_in)	LAMA3 LAMB3 KMT2D	1.34e-06	28	23	3	DOID:5409 (is_implicated_in)
Disease	Junctional epidermolysis bullosa gravis of Herlitz	LAMA3 LAMB3	1.74e-06	3	23	2	cv:C0079683
Disease	Junctional epidermolysis bullosa	LAMA3 LAMB3	1.74e-06	3	23	2	cv:C0079301
Disease	EPIDERMOLYSIS BULLOSA, JUNCTIONAL 1B, SEVERE	LAMA3 LAMB3	1.74e-06	3	23	2	226700
Disease	Herlitz Disease	LAMA3 LAMB3	3.48e-06	4	23	2	C0079683
Disease	Epidermolysis Bullosa Progressiva	LAMA3 LAMB3	3.48e-06	4	23	2	C0079297
Disease	Adult junctional epidermolysis bullosa (disorder)	LAMA3 LAMB3	5.80e-06	5	23	2	C0268374
Disease	EPIDERMOLYSIS BULLOSA, JUNCTIONAL, LOCALISATA VARIANT (disorder)	LAMA3 LAMB3	5.80e-06	5	23	2	C2608084
Disease	junctional epidermolysis bullosa non-Herlitz type (implicated_via_orthology)	LAMA3 LAMB3	5.80e-06	5	23	2	DOID:0060738 (implicated_via_orthology)
Disease	Junctional Epidermolysis Bullosa	LAMA3 LAMB3	8.70e-06	6	23	2	C0079301
Disease	junctional epidermolysis bullosa (is_implicated_in)	LAMA3 LAMB3	1.22e-05	7	23	2	DOID:3209 (is_implicated_in)
Disease	Amelogenesis imperfecta local hypoplastic form	LAMA3 LAMB3	1.22e-05	7	23	2	C0399367
Disease	cysteine-rich with EGF-like domain protein 1 measurement	BRPF1 BRD1	2.84e-04	32	23	2	EFO_0021870
Disease	complement factor D measurement	ZFAT C7	2.38e-03	93	23	2	EFO_0020283

Protein segments in the cluster

Peptide	Gene	Start	Entry
CHKANCYTAFHVTCA	BRD1	341	O95696
YHEHCFVCAQCFRPF	LIMS2	36	Q7Z4I7
CNCHGHASNCYYDPD	LAMA3	356	Q16787
FYADSRHCVPCHKDC	PCSK5	1361	Q92824
FQVLNSCPCKCYCHH	GGN	586	Q86UU5
KCRHYFCESCALQHF	RNF113A	276	O15541
SCGEHFCNECFDHYY	KDM1B	86	Q8NB78
KFCDCCYCEFFGHNA	FAM193B	411	Q96PV7
THCLCHCKPYTFGAA	C7	471	P10643
SCSSFFQQFFHCYCP	CRY1	401	Q16526
CCKCDSRQPHNYYSH	LAMB3	66	Q13751
QHCASPAFAYCGHSF	FBXL5	536	Q9UKA1
HSCFTCACGQPAYAH	FAM221A	151	A4D161
FRDHKYCCDDPHSFF	SHISAL2A	36	Q6UWV7
HCGDFDYHRTCSYSC	SHROOM4	876	Q9ULL8
ACIQCHKANCYTAFH	BRPF1	396	P55201
FKPFRCAHCHYSCNI	ZFAT	991	Q9P243
SFCEFCPHSFCKDHE	NSD3	1376	Q9BZ95
PFHCNECGKVFSYHS	ZNF879	371	B4DU55
YAFHCPHCDFACSNK	ZNF142	341	P52746
KFHTYAVHCCCFSPS	WDSUB1	51	Q8N9V3
FMASHFDRHYCGKCC	RPS27A	131	P62979
LFFCTSCGHHYHGAC	KMT2D	241	O14686