Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionall-trans retinal binding

OPN3 ADH4

4.30e-055422GO:0005503
DomainEGF

MEP1B CELSR1 FCGBP CELSR3 MEGF8 NOTCH4

1.34e-05235426SM00181
DomainEGF-like_dom

MEP1B CELSR1 FCGBP CELSR3 MEGF8 NOTCH4

1.86e-05249426IPR000742
DomainEGF_LAM_2

CELSR1 CELSR3 MEGF8

4.12e-0530423PS50027
DomainEGF_LAM_1

CELSR1 CELSR3 MEGF8

4.12e-0530423PS01248
DomainLaminin_EGF

CELSR1 CELSR3 MEGF8

6.58e-0535423PF00053
DomainEGF_Lam

CELSR1 CELSR3 MEGF8

6.58e-0535423SM00180
DomainASX_HYDROXYL

CELSR1 CELSR3 MEGF8 NOTCH4

7.41e-05100424PS00010
DomainLaminin_EGF

CELSR1 CELSR3 MEGF8

8.44e-0538423IPR002049
DomainEGF-type_Asp/Asn_hydroxyl_site

CELSR1 CELSR3 MEGF8 NOTCH4

9.29e-05106424IPR000152
DomainEGF_CA

CELSR1 CELSR3 MEGF8 NOTCH4

1.60e-04122424SM00179
DomainEGF-like_Ca-bd_dom

CELSR1 CELSR3 MEGF8 NOTCH4

1.70e-04124424IPR001881
DomainEGF_3

MEP1B CELSR1 CELSR3 MEGF8 NOTCH4

1.76e-04235425PS50026
DomainEGF

MEP1B CELSR1 CELSR3 NOTCH4

1.81e-04126424PF00008
DomainEGF_1

MEP1B CELSR1 CELSR3 MEGF8 NOTCH4

2.57e-04255425PS00022
DomainGAIN_dom_N

CELSR1 CELSR3

2.68e-0411422IPR032471
DomainGAIN

CELSR1 CELSR3

2.68e-0411422PF16489
DomainEGF-like_CS

MEP1B CELSR1 CELSR3 MEGF8 NOTCH4

2.86e-04261425IPR013032
DomainEGF_2

MEP1B CELSR1 CELSR3 MEGF8 NOTCH4

3.07e-04265425PS01186
DomainTIL

FCGBP MUC6

3.21e-0412422PF01826
DomainC8

FCGBP MUC6

3.21e-0412422PF08742
DomainGPCR_2_secretin-like

FZD8 CELSR1 CELSR3

3.31e-0460423IPR000832
DomainGPCR_2-like

FZD8 CELSR1 CELSR3

3.31e-0460423IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD8 CELSR1 CELSR3

3.48e-0461423PS50261
DomainUnchr_dom_Cys-rich

FCGBP MUC6

3.79e-0413422IPR014853
DomainC8

FCGBP MUC6

3.79e-0413422SM00832
DomainTIL_dom

FCGBP MUC6

4.42e-0414422IPR002919
DomainVWD

FCGBP MUC6

5.81e-0416422SM00216
DomainVWF_type-D

FCGBP MUC6

5.81e-0416422IPR001846
DomainVWFD

FCGBP MUC6

5.81e-0416422PS51233
DomainVWD

FCGBP MUC6

5.81e-0416422PF00094
DomainVWC_out

FCGBP MUC6

8.24e-0419422SM00215
DomainHormR

CELSR1 CELSR3

1.43e-0325422SM00008
DomainConA-like_dom

MEP1B CELSR1 CELSR3 NEURL4

1.45e-03219424IPR013320
DomainHRM

CELSR1 CELSR3

1.80e-0328422PF02793
DomainGPS

CELSR1 CELSR3

2.65e-0334422SM00303
DomainGPS

CELSR1 CELSR3

2.80e-0335422PF01825
DomainGPS

CELSR1 CELSR3

2.96e-0336422PS50221
DomainGPS

CELSR1 CELSR3

3.13e-0337422IPR000203
DomainLAM_G_DOMAIN

CELSR1 CELSR3

3.30e-0338422PS50025
DomainG_PROTEIN_RECEP_F2_1

CELSR1 CELSR3

3.65e-0340422PS00649
DomainGPCR_2_extracellular_dom

CELSR1 CELSR3

3.65e-0340422IPR001879
DomainLaminin_G_2

CELSR1 CELSR3

3.65e-0340422PF02210
DomainG_PROTEIN_RECEP_F2_3

CELSR1 CELSR3

3.65e-0340422PS50227
DomainVWF_dom

FCGBP MUC6

4.02e-0342422IPR001007
DomainLamG

CELSR1 CELSR3

4.40e-0344422SM00282
DomainGrowth_fac_rcpt_

CELSR1 MEGF8 NOTCH4

5.17e-03156423IPR009030
Domain-

KBTBD3 MEGF8

5.22e-03484222.120.10.80
DomainCUB

MEGF8 NETO1

5.43e-0349422PF00431
DomainG_PROTEIN_RECEP_F2_2

CELSR1 CELSR3

5.65e-0350422PS00650
Domain7tm_2

CELSR1 CELSR3

5.65e-0350422PF00002
DomainCUB

MEGF8 NETO1

5.65e-0350422SM00042
Domain-

MEGF8 NETO1

6.10e-03524222.60.120.290
DomainCUB

MEGF8 NETO1

6.33e-0353422PS01180
Pubmed

Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization.

KLK3 SLPI

1.64e-0624527539415
Pubmed

The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.

CELSR1 CELSR3

4.91e-06345211677057
Pubmed

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.

CELSR1 CELSR3

9.81e-06445237224017
Pubmed

Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia.

HSD3B1 KLK3

9.81e-06445216302261
Pubmed

RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.

LTK DUT

9.81e-06445210087292
Pubmed

Developmental expression profiles of Celsr (Flamingo) genes in the mouse.

CELSR1 CELSR3

9.81e-06445211850187
Pubmed

Dystroglycan is a scaffold for extracellular axon guidance decisions.

CELSR1 CELSR3

2.45e-05645230758284
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

FZD8 CELSR1 CELSR3

3.15e-054745333141892
Pubmed

Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.

CELSR1 CELSR3

3.42e-05745217937400
Pubmed

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.

KLK3 SLPI

3.42e-05745218714013
Pubmed

Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene.

LTK DUT

3.42e-0574529889000
Pubmed

Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.

CFH NOTCH4

4.56e-05845222694956
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

CELSR3 MEGF8

5.86e-0594529693030
Pubmed

Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem.

CELSR3 ADH4

7.32e-051045221106844
Pubmed

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.

LTK DUT

8.94e-051145210196361
Pubmed

A dual role for planar cell polarity genes in ciliated cells.

CELSR1 CELSR3

8.94e-051145225024228
Pubmed

Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.

CELSR1 CELSR3

1.07e-041245211891983
Pubmed

Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.

CELSR1 CELSR3

1.07e-041245220631168
Pubmed

A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.

CELSR1 CELSR3

1.47e-041445229784671
Pubmed

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.

CFH NOTCH4

1.47e-041445223620142
Pubmed

Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.

CELSR1 CELSR3

1.47e-041445239225402
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

CELSR1 CELSR3

1.70e-041545220473291
Pubmed

Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.

CFH NOTCH4

2.20e-041745223028341
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

LTK KCNQ5 NEURL4 NOTCH4

2.36e-0423345437704626
Pubmed

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

NAALADL2 NOTCH4

3.38e-042145221408207
Pubmed

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.

CFH NOTCH4

4.44e-042445211739537
Pubmed

Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.

HSD3B1 KLK3

4.82e-042545217507624
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CELSR1 CEP192 LTK SLC37A3 CELSR3 MEGF8 RGS16

5.07e-04110545735748872
Pubmed

Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.

CELSR1 CELSR3

5.22e-042645237228654
Pubmed

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.

ARHGEF18 USP13 MUC6 SLPI

5.60e-0429345431741433
Pubmed

Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.

CELSR1 CELSR3

7.92e-043245223177622
Pubmed

Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal.

HSD3B1 ADH4

7.92e-043245217270348
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

CELSR1 CELSR3

8.43e-043345225713288
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3

6.93e-063282913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3

6.93e-0632821189
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH CELSR1 FCGBP DNAH5 NAALADL2

1.10e-061824553f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CFH FCGBP DNAH5 KRT36 SLPI

1.29e-0618845507705bed928683470a52c8ccfa40ffb9a0971318
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP DNAJC10 SLPI ADH4

2.48e-05168454b275e951ff7109e36da22fc17bd4516f9b9432c4
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP DNAJC10 SLPI ADH4

2.48e-051684540757a5af953901a8faed5774ffec4755fc9c0a6e
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP DNAJC10 SLPI ADH4

2.48e-05168454a0dbe2ee697e29b32aa5f8326445e067ff66c154
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FZD8 KBTBD3 CELSR1 ITLN2

2.54e-051694546614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FZD8 KBTBD3 CELSR1 ITLN2

2.54e-05169454665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH CELSR1 FCGBP SLPI

3.04e-05177454779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH CELSR1 FCGBP SLPI

3.04e-051774540f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP DNAJC10 MUC6 SLPI

3.54e-0518445401c19a830348ab0b9c02c1546a439de70ee10f97
ToppCell(5)_Glands_duct|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

FCGBP KLK3 NAALADL2 NTM-AS1

3.69e-05186454ad8d5010e5095508f4995e0c6c016a44e8ffb8dd
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

CELSR1 DNAH5 NAALADL2 SLPI

4.01e-0519045451ca9ef4df3220487152fcf684147730637c7cc1
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP DNAJC10 MUC6 SLPI

4.01e-051904543c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP DNAJC10 MUC6 SLPI

4.01e-0519045423f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCellCOVID-19-lung-Secretory|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFH CELSR1 DNAH5 SLPI

4.18e-0519245459261098ccb52306f837f632ebaea45b90ad30fe
ToppCellEnterocyte_Progenitors-C_06|Enterocyte_Progenitors / shred on cell type and cluster

CFH FCGBP MUC6 SLPI

4.18e-05192454b9938e1a929c00628cc6ebfdf10cf285167f445c
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITLN2 FCGBP LTK KLK3

4.26e-05193454402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITLN2 FCGBP LTK KLK3

4.26e-051934547ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH FCGBP MUC6 SLPI

4.35e-051944545402835d6b252276e458001949dd1cb5aa744b0e
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

FZD8 KBTBD3 CELSR1 ITLN2

4.35e-0519445488db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

FZD8 KBTBD3 CELSR1 ITLN2

4.35e-05194454a71728202493d4858342ea2756ea281cd0d99a3a
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH FCGBP MUC6 SLPI

4.35e-051944542c0236a102f7fec6d508afec6137da5b26a65931
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH CELSR1 FCGBP SLPI

4.44e-05195454576142b4e75457c0973051bccc4163bd624496af
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH CELSR1 FCGBP SLPI

4.44e-051954548f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH CELSR1 FCGBP SLPI

4.44e-051954542a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell15-Trachea|15 / Age, Tissue, Lineage and Cell class

CELSR1 FCGBP DNAH5 SLPI

4.53e-05196454fd17403422cf95c24f6be1c2d78764bb352f7f2e
ToppCelldroplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARPIN DNAJC10 MEGF8

3.49e-04136453a43b3db1754c619d328a26a2ba6af4756629a723
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

ITLN2 FCGBP KLK3

3.65e-04138453e1e936ff4080bda2810c5fd1154a706359f377a5
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TSPAN16 NETO1 MUC6

3.96e-0414245366135fee18448cc09a78bc6ede05afd63c72ae21
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FCGBP NETO1 SLPI

4.30e-04146453d33bd571c2adf5f89e6f02e77d094c19edd4729c
ToppCellClub_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

CFH DNAH5 SLPI

4.38e-041474535a824c89e4d045af465d7333275f8191fb29b041
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CELSR1 KCNQ5 DNAH5

4.47e-041484539fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCellSerous|World / shred by cell class for turbinate

FCGBP KLK3 SLPI

4.65e-041504536a326662d58b0f17d6efa8cc28571f4cbbf57c2d
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH FCGBP DNAH5

4.83e-041524531b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCell356C-Lymphocytic-NK_cells-NK_cell_D2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CFH ARHGEF18 ARPIN

5.02e-041544538dc8f02534c3ebda30bf9e702e36d0c53d89e5a5
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH CELSR1 DNAH5

5.41e-04158453d78e7e52657dc094430291fec07e9c298be9e584
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFH KCNQ5 NETO1

5.51e-041594539f6607e395bcca9cb1c83199bdbbaaa62a93938d
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF18 MUC6 NEURL4

5.51e-041594537619d0d49738dd08daf01b42664691a5323aa793
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH PLAC8L1 DUT

5.51e-041594531baf0eaf9684668146a63192e77eec6c3c7a37f8
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF18 MUC6 NEURL4

5.51e-041594534000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFH KCNQ5 NETO1

5.51e-04159453c8b42ebc25ebcc450832096fbffaa5c5f5fe88e7
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

5.92e-04163453f6847f47a8856c0d4136c1af317432d45eccfde9
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

5.92e-04163453a1fbefe53523a9879a4d4b493071059798b5f917
ToppCell5'-Airway_Nasal_SMG|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

5.92e-04163453d8450bf9c6d2ec5dd1472952c9e65f82f995337a
ToppCell5'-Airway_Nasal_SMG-Epithelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

5.92e-04163453454a5e87e2f9f66e38cc5aa1b433c47b54c9be42
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

5.92e-04163453be6cc44df9a2b10dce1a353717c279c3558f8fec
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

5.92e-04163453d9bd9d90cfa4e85d5ea51f8f3ee14a700571f508
ToppCellSevere-Lymphoid-NK-CCR7+_T|Severe / Condition, Lineage, Cell class and cell subclass

LTK NAALADL2 RGS16

5.92e-041634538f0d8c124f1569a5a6bc1db7581989f24d63cca3
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH LTK RGS16

6.03e-04164453e86899aa68aac572009618c7e017e6734b86357c
ToppCellsevere-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

LTK OPN3 NOTCH4

6.25e-04166453ae38850fde549b8dd6fb12f0ef80b428ade50485
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

6.25e-041664539e98e6070055bfc780becee52d77830e06b6d854
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

CFH CELSR1 FCGBP

6.36e-041674536efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH JPH4 MUC6

6.36e-04167453d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH JPH4 MUC6

6.36e-041674537abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF18 WDR12 CELSR1

6.36e-04167453754e6412d3b9cc0b126e59593df2f5956b4712ef
ToppCell390C-Myeloid-Dendritic-pDC|390C / Donor, Lineage, Cell class and subclass (all cells)

LTK OPN3 NOTCH4

6.47e-041684535a2e7a52b7330dce30823695a7b9b26bc47a69ce
ToppCellControl-CD4+_T|World / Disease group and Cell class

CFH ARPIN RGS16

6.58e-04169453e330d85bd37a1bd1c3d8d29ddd8a2c1020a62a83
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ABAT CEP192 SERGEF

6.69e-04170453ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCellnormal-na-Lymphocytic_B-B_plasma-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

CELSR1 LTK RGS16

6.69e-04170453c5b87974dfddf9780051f7f5693eeeb0c606a3fe
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

CFH ABAT NOTCH4

6.81e-04171453c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

CFH CELSR1 ADH4

6.81e-041714533965ced4be6db14265a90673502fceee425837ca
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP NAALADL2 SLPI

6.92e-041724535401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP NAALADL2 SLPI

6.92e-04172453b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

ABAT FCGBP MEGF8

6.92e-04172453f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP NAALADL2 SLPI

6.92e-0417245374dd4a7acb2cf857fed20219e4d7dc1adfbaa398
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.4|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH FCGBP SLPI

7.04e-04173453176b956e71d98e8275d698b39437fc326e5fe449
ToppCell(6)_Endothelial_cells-(6)_Endothelial-E|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

LTK NOTCH4 SLPI

7.16e-041744534a1b67ce5ea353b3f81f59fa57da07668146afca
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|356C / Donor, Lineage, Cell class and subclass (all cells)

CFH FCGBP DNAH5

7.28e-041754534bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCellIPF-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

MEP1B KCNQ5 NAALADL2

7.28e-04175453b6d1e40d9339426d778481fd67ab7cbc0f6cb5b2
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|356C / Donor, Lineage, Cell class and subclass (all cells)

CFH FCGBP DNAH5

7.28e-04175453af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LTK KCNQ5 NETO1

7.28e-041754538362a46f5804333baa84cd56d450bc147f372a7e
ToppCellfacs-Kidney-nan-18m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTK KCNQ5 RGS16

7.28e-0417545384d91843b34504636d5af6bda9930031409a1627
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LTK KCNQ5 NETO1

7.28e-041754538b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellfacs-Kidney-nan-18m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTK KCNQ5 RGS16

7.28e-041754532368aa8318ab83e0e0fd539a17264f9e1d755cf1
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

ARHGEF18 KCNQ5 NETO1

7.40e-04176453d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCellAdult-Epithelial-club_cell-D175|Adult / Lineage, Cell type, age group and donor

CFH CELSR1 DNAH5

7.52e-04177453d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCellHealthy/Control-pDC|Healthy/Control / Disease group and Cell class

LTK OPN3 NOTCH4

7.65e-04178453072b346c6bbd63f00efaceda486400a669b3ec48
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH CELSR1 DNAH5

7.65e-04178453fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-large_intestine_goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGBP RGS16 SLPI

7.65e-0417845307d6d5275a4d17f8024fde74e92ab2505b4adfbf
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP NAALADL2 SLPI

7.77e-04179453ec331b1132f965581f851a3b29e62873c4140e6c
ToppCellmild-Myeloid-pDC|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

LTK OPN3 NOTCH4

7.90e-0418045338614155fa537d0defda914c531c697be0ef06d8
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CFH ITLN2 NOTCH4

7.90e-041804535861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH CELSR1 DNAH5

7.90e-04180453b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellIPF-Lymphoid-B|World / Disease state, Lineage and Cell class

ARHGEF18 KCNQ5 NETO1

7.90e-0418045330f9398c9b784f49470847a025bac90687e997a1
ToppCell5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH RGS16 SLPI

8.02e-0418145365eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH RGS16 SLPI

8.02e-04181453eaac7d58117eddfff06b25521efc431c1351d592
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CFH FCGBP SLPI

8.02e-04181453bab282cb0d9fc049f6fb094cf8b1fba104f4ea17
ToppCellHealthy/Control-pDC|World / Disease group and Cell class

LTK OPN3 NOTCH4

8.15e-0418245397e0eee10905f2cf2bebb09e474629fc224f4397
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH CELSR1 DNAH5

8.15e-04182453215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellControl-Epithelial-Basal|Control / Disease state, Lineage and Cell class

CFH CELSR1 SLPI

8.15e-04182453caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

CELSR1 FCGBP SLPI

8.28e-04183453940cbe298e9c53b5622af09264586ed823d3141f
ToppCellwk_20-22-Mesenchymal-Mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFH ITLN2 SLPI

8.42e-04184453804f8a41cd6b1361448872bf352bf0a38a0fac66
ToppCellwk_20-22-Mesenchymal-Mesothelial-Late_mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFH ITLN2 SLPI

8.42e-0418445360dd055c2e2e92b838ac649c12e8cccd9c3b1b71
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CFH ITLN2 SLPI

8.55e-04185453492529121cb9e88bd3c0db6b54af3cd2979572bc
ToppCell(7)_MNP-(7)_DC_plasmacytoid|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

LTK OPN3 NOTCH4

8.55e-041854539f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

LTK OPN3 NOTCH4

8.55e-041854537fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellcontrol-Myeloid-pDC|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

LTK OPN3 NOTCH4

8.68e-04186453fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LTK OPN3 NOTCH4

8.68e-04186453b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CELSR1 KCNQ5 DNAH5

8.68e-041864532ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LTK OPN3 NOTCH4

8.68e-0418645331df1eafa3010bc1be6fc4d4689f1393d69b6b13
Diseasecancer aggressiveness measurement, Gleason score measurement, prostate carcinoma

KLK3 NAALADL2

2.07e-055432EFO_0001663, EFO_0006999, EFO_0007000
Diseasecentral serous retinopathy

CFH NOTCH4

5.78e-058432EFO_0009784
Diseasekidney disease

CFH NOTCH4

5.78e-058432EFO_0003086
Diseaseubiquitin-conjugating enzyme E2 G2 measurement

CFH NOTCH4

9.27e-0510432EFO_0022035
DiseaseSLAM family member 7 measurement

CFH ITLN2

2.78e-0417432EFO_0008287
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

HSD3B1 SLPI

4.28e-0421432DOID:11612 (biomarker_via_orthology)
Diseasecomplement factor H-like 1 protein measurement

CFH KLK3

4.70e-0422432EFO_0600092
Diseasemyeloperoxidase measurement

CFH NOTCH4

6.59e-0426432EFO_0005243
Diseaseesophageal carcinoma

NAALADL2 ADH4

8.79e-0430432EFO_0002916
Diseasevisceral heterotaxy (implicated_via_orthology)

MEGF8 DNAH5

1.34e-0337432DOID:0050545 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GLKTWTQGCLSGGGT

ARHGEF18

121

Q6ZSZ5
MTGWSCLVTGAGGFL

HSD3B1

1

P14060
GWGSCTFIGVAAGSK

ADH4

291

P08319
VWTGGAGSKWGCSAG

AFDN-DT

86

Q9Y6Z5
AGSKWGCSAGSGRAV

AFDN-DT

91

Q9Y6Z5
TGGAGSKWAVLGSAG

AFDN-DT

171

Q9Y6Z5
TKCNFTGDGKTGASW

ARPIN

181

Q7Z6K5
GETSGSITCGKDGWS

CFH

486

P08603
CVFWNHSLAVGGTGG

CELSR1

2411

Q9NYQ6
CGTWTKHAEGGIFTS

NETO1

41

Q8TDF5
WKGEGSFECAGFNAG

KBTBD3

531

Q8NAB2
DKGQCSTWGAGHFST

MUC6

41

Q6W4X9
AGWCLSGGGRKVSSL

NTM-AS1

51

Q6ZSK4
CAVSGGSISSGGYSW

IGHV4-30-2

41

A0A087WSY4
GGAAGLWVKSGAAAA

KCNQ5

11

Q9NR82
LWVKSGAAAAAAGGG

KCNQ5

16

Q9NR82
DEVQTGGGCTGKFWA

ABAT

326

P80404
GCWAHGFESLGVFTG

JPH4

41

Q96JJ6
GSWLFSTCGASGRHG

LTK

66

P29376
GSRLTGAGWGGCTVS

GALK2

396

Q01415
WGFNASVGSARCGSG

MEGF8

1396

Q7Z7M0
GCRGASTVGAAGWKG

DUT

66

P33316
TVGCVWDGFSGSLFG

OPN3

111

Q9H1Y3
CWASKGAAVGGGAGA

FZD8

621

Q9H461
FGAAWRAPGSSKGCG

FCGBP

5011

Q9Y6R7
FCDMTSGGGGWTLVA

ITLN2

81

Q8WWU7
GICLGSNIGSGWMGT

CEP192

1311

Q8TEP8
GIGWLITFCSKGGDC

DNAJC10

256

Q8IXB1
WGSFSCDCPVGFGGK

CELSR3

1741

Q9NYQ7
ISVFKGSGCWSSVGN

MEP1B

116

Q16820
AWGGTCGAALTGTSI

ECSIT

16

Q9BQ95
TGLKGGSWVVSGCSV

NEURL4

121

Q96JN8
GRIFKGLAQSGSWGC

DNAH5

2016

Q8TE73
ECHTSGFVGSGGWFC

KRT36

71

O76013
GGWFCEGSFNGSEKE

KRT36

81

O76013
GVTGWCTGFIFQKVG

FUNDC2

91

Q9BWH2
SGIVFQWGTGLASCG

SERGEF

171

Q9UGK8
WAVEGSGKSFKAGVC

SLPI

21

P03973
VQTGGGWSTGLFSVC

PLAC8L1

66

A1L4L8
AGSFHCVCVSGWGGT

NOTCH4

336

Q99466
LGCAGWYGATKESRG

TSPAN16

71

Q9UKR8
GKAGRGVVFGLWSAC

SLC37A3

171

Q8NCC5
ELGCDTGSTGKFEWG

RGS16

31

O15492
AVDGSGTKFCSGSWD

WDR12

196

Q9GZL7
GGLCVVWGSASYAVG

TMEM160

106

Q9NX00
DGSVLCGKWFFDSSG

USP13

226

Q92995
CGKWFFDSSGGNGHA

USP13

231

Q92995
FASGDSGAGCWSVSG

TPP1

356

O14773
RWTGGKSTCSGDSGG

KLK3

201

P07288
IVFCSWGGTAFGNIG

NAALADL2

491

Q58DX5