Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

TRIM72 FBXO40 TRIM25 TRIM58 C10orf90 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 TRIM50 RNF180 LNX1 UBE2E3

3.05e-1047314720GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

TRIM72 FBXO40 TRIM25 TRIM58 C10orf90 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 TRIM50 RNF180 LNX1 UBE2E3

1.21e-0951214720GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

TRIM72 FBXO40 TRIM25 TRIM58 C10orf90 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 TRIM50 RNF180 LNX1 UBE2E3

2.33e-0953214720GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

TRIM72 FBXO40 TRIM25 TRIM58 C10orf90 MBOAT4 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 NCOA1 RNF216 TRIM50 KAT6B RNF180 LNX1 UBE2E3

1.19e-0877514723GO:0016746
GeneOntologyMolecularFunctionubiquitin protein ligase activity

TRIM72 FBXO40 TRIM25 TRIM58 C10orf90 TRIM5 FBXO30 RNF220 UBE2D1 UBE2D2 UBE2D3 RNF10 RNF216 TRIM50 RNF180

1.09e-0737214715GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

TRIM72 FBXO40 TRIM25 TRIM58 C10orf90 TRIM5 FBXO30 RNF220 UBE2D1 UBE2D2 UBE2D3 RNF10 RNF216 TRIM50 RNF180

2.59e-0739814715GO:0061659
GeneOntologyMolecularFunctionubiquitin conjugating enzyme activity

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

2.77e-07371476GO:0061631
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

7.00e-07431476GO:0061650
GeneOntologyMolecularFunctiontransition metal ion binding

TRIM72 UBA5 FBXO40 TUT4 MID2 CYP2E1 TRIM58 MYO9B ZFAND2B AOC2 USP16 TRIM5 FBXO30 RNPEP MID1 CPXM1 RNF216 ALAD CYP4F12 TRIM50 ZSWIM4 CYP4F11 PPM1N PRIMPOL

6.19e-06118914724GO:0046914
GeneOntologyMolecularFunctionzinc ion binding

TRIM72 UBA5 FBXO40 TUT4 MID2 TRIM58 MYO9B ZFAND2B USP16 TRIM5 FBXO30 RNPEP MID1 CPXM1 RNF216 ALAD TRIM50 ZSWIM4 PRIMPOL

3.03e-0589114719GO:0008270
GeneOntologyMolecularFunctionalpha-L-arabinofuranosidase activity

OTOGL OTOG

5.38e-0521472GO:0046556
GeneOntologyMolecularFunctiondihydrosphingosine-1-phosphate phosphatase activity

SGPP2 SGPP1

5.38e-0521472GO:0070780
GeneOntologyMolecularFunctionalpha-tocopherol omega-hydroxylase activity

CYP4F12 CYP4F11

5.31e-0451472GO:0052871
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2E1 CYP4F12 CYP4F11

7.06e-04241473GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2E1 CYP4F12 CYP4F11

1.00e-03271473GO:0008391
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4F12 CYP4F11

1.10e-0371472GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4F12 CYP4F11

1.10e-0371472GO:0018685
GeneOntologyMolecularFunctionsphingosine-1-phosphate phosphatase activity

SGPP2 SGPP1

1.10e-0371472GO:0042392
GeneOntologyBiologicalProcessprotein K48-linked ubiquitination

TRIM25 SKP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF216 UBE2E3

4.07e-081001479GO:0070936
GeneOntologyBiologicalProcessprotein ubiquitination

TRIM72 TRIM25 MID2 TRIM58 C10orf90 SKP2 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ASB16 RNF10 RNF216 TRIM50 RNF180 LNX1 UBE2E3

7.11e-0881114722GO:0016567
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

TRIM72 UBA5 TRIM25 MID2 TRIM58 C10orf90 SKP2 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ASB16 RNF10 RNF216 TRIM50 RNF180 LNX1 UBE2E3

8.85e-0889314723GO:0032446
GeneOntologyBiologicalProcessprotein polyubiquitination

TRIM25 TRIM58 C10orf90 SKP2 TRIM5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF216 RNF180 UBE2E3

1.60e-0728914713GO:0000209
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

TRIM72 UBA5 TRIM25 MID2 TRIM58 C10orf90 SKP2 USP16 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ASB16 RNF10 RNF216 TRIM50 RNF180 LNX1 UBE2E3

1.95e-07100914724GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

TRIM72 UBA5 TRIM25 MID2 TRIM58 C10orf90 SKP2 USP16 TRIM5 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ASB16 RNF10 RNF216 TRIM50 RNF180 LNX1 UBE2E3

6.03e-07107414724GO:0043687
GeneOntologyBiologicalProcessmodification-dependent macromolecule catabolic process

TRIM72 TUT4 TRIM25 TRIM58 ZFAND2B APC2 SKP2 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 RNF180 LNX1

4.56e-0665614717GO:0043632
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process

TRIM72 TRIM25 TRIM58 ZFAND2B APC2 SKP2 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 RNF180 LNX1

1.38e-0564014716GO:0006511
GeneOntologyBiologicalProcessmodification-dependent protein catabolic process

TRIM72 TRIM25 TRIM58 ZFAND2B APC2 SKP2 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 RNF180 LNX1

1.70e-0565114716GO:0019941
GeneOntologyBiologicalProcessprotein K63-linked ubiquitination

SKP2 TRIM5 UBE2D2 UBE2D3 UBE2D4 UBE2E3

1.72e-05761476GO:0070534
GeneOntologyBiologicalProcessprotein autoubiquitination

TRIM58 TRIM5 RNF220 UBE2D2 UBE2D3 RNF10

1.99e-05781476GO:0051865
GeneOntologyBiologicalProcessnegative regulation of viral entry into host cell

TRIM25 MID2 TRIM5 GSN

4.44e-05281474GO:0046597
GeneOntologyBiologicalProcessregulation of viral entry into host cell

TRIM25 MID2 TRIM58 TRIM5 GSN

4.48e-05551475GO:0046596
GeneOntologyBiologicalProcessarabinose metabolic process

OTOGL OTOG

5.05e-0521472GO:0019566
GeneOntologyBiologicalProcessvibrational conductance of sound to the inner ear

OTOGL OTOG

5.05e-0521472GO:0055127
GeneOntologyBiologicalProcessL-arabinose metabolic process

OTOGL OTOG

5.05e-0521472GO:0046373
GeneOntologyBiologicalProcessproteolysis involved in protein catabolic process

TRIM72 TRIM25 TRIM58 ZFAND2B APC2 SKP2 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 ALAD RNF180 LNX1

6.92e-0581214717GO:0051603
GeneOntologyBiologicalProcessmodulation by symbiont of entry into host

TRIM25 MID2 TRIM58 TRIM5 GSN

8.01e-05621475GO:0052372
GeneOntologyBiologicalProcessnegative regulation of viral life cycle

TRIM25 MID2 TRIM5 GSN

8.63e-05331474GO:1903901
GeneOntologyBiologicalProcessprotein K29-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

9.63e-05131473GO:0035519
GeneOntologyBiologicalProcessartery smooth muscle contraction

EDN3 CACNA1G SMPD3

9.63e-05131473GO:0014824
GeneOntologyBiologicalProcessprotein K27-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

1.22e-04141473GO:0044314
GeneOntologyBiologicalProcessprotein K11-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4 UBE2E3

1.36e-04371474GO:0070979
GeneOntologyBiologicalProcessmenaquinone catabolic process

CYP4F12 CYP4F11

1.51e-0431472GO:0042361
GeneOntologyBiologicalProcesstonic smooth muscle contraction

EDN3 CACNA1G SMPD3

1.52e-04151473GO:0014820
GeneOntologyBiologicalProcessregulation of biological process involved in symbiotic interaction

TRIM25 MID2 TRIM58 TRIM5 GSN

1.98e-04751475GO:0043903
GeneOntologyBiologicalProcessprotein K6-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

2.24e-04171473GO:0085020
GeneOntologyBiologicalProcesssuppression of viral release by host

TRIM25 MID2 TRIM5

2.68e-04181473GO:0044790
GeneOntologyBiologicalProcessmenaquinone metabolic process

CYP4F12 CYP4F11

3.00e-0441472GO:0009233
GeneOntologyBiologicalProcessphylloquinone metabolic process

CYP4F12 CYP4F11

3.00e-0441472GO:0042374
GeneOntologyBiologicalProcessphylloquinone catabolic process

CYP4F12 CYP4F11

3.00e-0441472GO:0042376
GeneOntologyBiologicalProcessvitamin K catabolic process

CYP4F12 CYP4F11

3.00e-0441472GO:0042377
GeneOntologyBiologicalProcessprotein catabolic process

TRIM72 TRIM25 TRIM58 ZFAND2B APC2 SKP2 TRIM5 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 RNF216 IRAK3 ALAD RNF180 LNX1

3.69e-04111514719GO:0030163
GeneOntologyBiologicalProcesssphingolipid catabolic process

SGPP2 SGPP1 GLA SMPD3

4.09e-04491474GO:0030149
GeneOntologyBiologicalProcessprotein monoubiquitination

TRIM25 RNF220 UBE2D3 RNF10

5.94e-04541474GO:0006513
GeneOntologyBiologicalProcessmembrane lipid catabolic process

SGPP2 SGPP1 GLA SMPD3

6.37e-04551474GO:0046466
GeneOntologyBiologicalProcessregulation of Rab protein signal transduction

DENND4A DENND4C

7.43e-0461472GO:0032483
GeneOntologyBiologicalProcessleukotriene B4 catabolic process

CYP4F12 CYP4F11

7.43e-0461472GO:0036101
GeneOntologyBiologicalProcessprostaglandin catabolic process

CYP4F12 CYP4F11

7.43e-0461472GO:1905344
GeneOntologyBiologicalProcessprostanoid catabolic process

CYP4F12 CYP4F11

7.43e-0461472GO:0062232
GeneOntologyBiologicalProcessproteasomal protein catabolic process

TRIM72 TRIM25 ZFAND2B APC2 SKP2 CUL5 UBE2D1 UBE2D3 RNF10 RNF216 ALAD RNF180

7.68e-0456714712GO:0010498
DomainUBQ-conjugating_AS

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

3.09e-08251456IPR023313
DomainUQ_con

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

5.21e-07391456PF00179
DomainZnf_RING_CS

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 RNF10 TRIM50 RNF180 LNX1

5.83e-0716314510IPR017907
DomainUBIQUITIN_CONJUGAT_1

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

6.09e-07401456PS00183
DomainUBIQUITIN_CONJUGAT_2

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

7.09e-07411456PS50127
DomainUBQ-conjugat_E2

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

7.09e-07411456IPR000608
DomainButyrophylin

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

1.17e-06701457IPR003879
Domain-

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

1.29e-067114574.10.45.10
Domain-

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

2.67e-065114563.10.110.10
DomainZF_RING_1

TRIM72 TRIM25 MID2 TRIM58 TRIM5 RNF220 MID1 RNF10 RNF216 TRIM50 RNF180 LNX1

2.92e-0629114512PS00518
DomainZnf_B-box

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

3.16e-06811457IPR000315
DomainUBQ-conjugating_enzyme/RWD

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

3.36e-06531456IPR016135
DomainZF_RING_2

TRIM72 TRIM25 MID2 TRIM58 TRIM5 RNF220 MID1 RNF10 RNF216 TRIM50 RNF180 LNX1

3.73e-0629814512PS50089
DomainSPRY

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

5.11e-06871457SM00449
Domainzf-RING_UBOX

TRIM25 MID2 TRIM5 MID1 TRIM50

6.11e-06341455PF13445
DomainZnf-RING_LisH

TRIM25 MID2 TRIM5 MID1 TRIM50

6.11e-06341455IPR027370
DomainZnf_C3HC4_RING-type

TRIM72 TRIM25 MID2 TRIM58 TRIM5 RNF10 TRIM50 RNF180 LNX1

8.02e-061721459IPR018957
DomainConA-like_dom

TRIM72 FAT4 TRIM25 MID2 TRIM58 TRIM5 CELSR3 MID1 TRIM50 CRB2

8.32e-0621914510IPR013320
DomainSPRY

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

8.56e-06941457PF00622
DomainSPRY_dom

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

8.56e-06941457IPR003877
DomainB30.2/SPRY

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

9.19e-06951457IPR001870
DomainB302_SPRY

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

9.19e-06951457PS50188
Domainzf-C3HC4

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 RNF10 TRIM50 RNF180 LNX1

9.74e-0622314510PF00097
DomainBBOX

TRIM72 MID2 TRIM58 TRIM5 MID1 TRIM50

1.58e-05691456SM00336
DomainPRY

TRIM72 TRIM25 TRIM58 MID1 TRIM50

1.78e-05421455PF13765
Domainzf-B_box

TRIM72 MID2 TRIM58 TRIM5 MID1 TRIM50

2.02e-05721456PF00643
DomainRING

TRIM72 TRIM25 MID2 TRIM58 TRIM5 RNF220 MID1 RNF10 TRIM50 RNF180 LNX1

2.67e-0530514511SM00184
DomainPRY

TRIM72 TRIM25 TRIM58 MID1 TRIM50

3.44e-05481455SM00589
DomainPRY

TRIM72 TRIM25 TRIM58 MID1 TRIM50

3.44e-05481455IPR006574
DomainZF_BBOX

TRIM72 MID2 TRIM58 TRIM5 MID1 TRIM50

3.70e-05801456PS50119
Domain-

TRIM72 TRIM25 MID2 TRIM58 USP16 TRIM5 RNF220 MID1 RNF10 TRIM50 KAT6B RNF180 LNX1

4.90e-05449145133.30.40.10
DomainZnf_RING

TRIM72 TRIM25 MID2 TRIM58 TRIM5 RNF220 MID1 RNF10 TRIM50 RNF180 LNX1

4.90e-0532614511IPR001841
Domainzf-TRAF_2

FBXO40 FBXO30

5.99e-0521452PF15965
DomainF-box_4

FBXO40 FBXO30

5.99e-0521452PF15966
DomainFbxo30/Fbxo40

FBXO40 FBXO30

5.99e-0521452IPR031890
DomainZnf_RING/FYVE/PHD

TRIM72 TRIM25 MID2 TRIM58 USP16 TRIM5 RNF220 MID1 RNF10 TRIM50 KAT6B RNF180 LNX1

6.13e-0545914513IPR013083
DomainVWF_type-D

FCGBP SUSD2 OTOG

2.38e-04161453IPR001846
DomainVWFD

FCGBP SUSD2 OTOG

2.38e-04161453PS51233
DomainVWD

FCGBP SUSD2 OTOG

2.38e-04161453SM00216
DomainVWD

FCGBP SUSD2 OTOG

2.38e-04161453PF00094
DomainPPR

DENND4A DENND4C

3.56e-0441452PF01535
DomainRubredoxin-type_fold

MCM8 MCM6

3.56e-0441452IPR004039
Domain-

MCM8 MCM6

3.56e-04414522.20.28.10
DomainMCM_OB

MCM8 MCM6

1.63e-0381452PF17207
DomainMCM_OB

MCM8 MCM6

1.63e-0381452IPR033762
DomainPPR

DENND4A DENND4C

1.63e-0381452PS51375
DomainMCM_2

MCM8 MCM6

1.63e-0381452PS50051
DomainMCM_1

MCM8 MCM6

1.63e-0381452PS00847
DomainMCM

MCM8 MCM6

2.08e-0391452SM00350
DomainMCM_dom

MCM8 MCM6

2.08e-0391452IPR001208
DomainMCM

MCM8 MCM6

2.08e-0391452IPR031327
DomainMCM

MCM8 MCM6

2.08e-0391452PF00493
DomainLAM_G_DOMAIN

FAT4 CELSR3 CRB2

3.17e-03381453PS50025
DomainEGF-like_dom

FAT4 LRP1B FCGBP CELSR3 C8B CRB2 OTOG

3.35e-032491457IPR000742
DomainLaminin_G_2

FAT4 CELSR3 CRB2

3.67e-03401453PF02210
DomainCOS

MID2 MID1

3.75e-03121452PS51262
DomainZnf_TRAF

FBXO40 FBXO30

3.75e-03121452IPR001293
DomainC8

FCGBP OTOG

3.75e-03121452PF08742
DomainTIL

FCGBP OTOG

3.75e-03121452PF01826
DomainCOS_domain

MID2 MID1

3.75e-03121452IPR017903
DomainZF_TRAF

FBXO40 FBXO30

4.41e-03131452PS50145
DomainUnchr_dom_Cys-rich

FCGBP OTOG

4.41e-03131452IPR014853
DomainC8

FCGBP OTOG

4.41e-03131452SM00832
DomainLamG

FAT4 CELSR3 CRB2

4.81e-03441453SM00282
DomainTIL_dom

FCGBP OTOG

5.12e-03141452IPR002919
Domain-

FBXO40 FBXO30

5.12e-031414523.90.890.10
DomainCyt_P450_E_grp-I

CYP2E1 CYP4F12 CYP4F11

5.12e-03451453IPR002401
DomainBbox_C

MID2 MID1

5.88e-03151452IPR003649
DomainBBC

MID2 MID1

5.88e-03151452SM00502
DomainDENN

DENND4A DENND4C

6.69e-03161452SM00799
DomainDENN

DENND4A DENND4C

6.69e-03161452PF02141
DomaindDENN

DENND4A DENND4C

6.69e-03161452PF03455
DomainSIAH-type

FBXO40 FBXO30

6.69e-03161452IPR013323
DomainUDENN

DENND4A DENND4C

6.69e-03161452PS50946
DomainDDENN

DENND4A DENND4C

6.69e-03161452PS50947
DomaindDENN

DENND4A DENND4C

6.69e-03161452SM00801
DomaindDENN_dom

DENND4A DENND4C

6.69e-03161452IPR005112
DomainuDENN_dom

DENND4A DENND4C

6.69e-03161452IPR005113
DomainDENN

DENND4A DENND4C

6.69e-03161452PS50211
DomainDENN_dom

DENND4A DENND4C

6.69e-03161452IPR001194
DomainASX_HYDROXYL

FAT4 LRP1B CELSR3 CRB2

7.69e-031001454PS00010
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

UBA5 FBXO40 SKP2 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ASB16 TRIM50 LNX1 UBE2E3

7.28e-0930810415M1070
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

UBA5 FBXO40 SKP2 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ASB16 TRIM50 LNX1 UBE2E3

1.22e-0738110415M1066
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

UBA5 FBXO40 SKP2 FBXO30 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 ASB16 TRIM50 LNX1 UBE2E3

2.95e-0729910413MM15711
PathwayKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS

SKP2 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 MID1 UBE2E3

6.60e-071351049M15247
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

UBA5 FBXO40 SKP2 FBXO30 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 ASB16 TRIM50 LNX1 UBE2E3

1.39e-0634310413MM15712
PathwayREACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING

TRIM25 UBE2D1 UBE2D2 UBE2D3 RNF216

5.40e-06351045M985
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

CUL5 UBE2D1 UBE2D2 UBE2D3

3.14e-05251044M41829
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

CUL5 UBE2D1 UBE2D2 UBE2D3

6.61e-05301044M41825
PathwayREACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES

UBE2D1 UBE2D2 UBE2E1 UBE2E3

6.61e-05301044M27762
PathwayREACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES

UBE2D1 UBE2D2 UBE2E1 UBE2E3

6.61e-05301044MM15507
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

UBA5 FBXO40 SKP2 FBXO30 CUL5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ASB16 NFKBIE TRIM50 SIGLEC1 LNX1 UBE2E3

1.10e-0482810417M1058
PathwayREACTOME_PROTEIN_UBIQUITINATION

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

1.15e-04651045MM15490
PathwayKEGG_SPHINGOLIPID_METABOLISM

SGPP2 SGPP1 GLA SMPD3

1.89e-04391044M15955
PathwayREACTOME_PROTEIN_UBIQUITINATION

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

2.90e-04791045M27742
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

UBE2D1 UBE2D2 UBE2D3

2.94e-04181043MM15680
PathwayREACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS

UBE2D1 UBE2D2 UBE2D3 UBE2E1

3.30e-04451044MM15508
PathwayREACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA

TRIM25 UBE2D1 UBE2D2 UBE2D3 RNF216

3.45e-04821045M1002
PathwayREACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT

UBE2D1 UBE2D2 UBE2D3

3.47e-04191043M27020
PathwayREACTOME_ABERRANT_REGULATION_OF_MITOTIC_EXIT_IN_CANCER_DUE_TO_RB1_DEFECTS

SKP2 UBE2D1 UBE2E1

4.06e-04201043M39015
PathwayREACTOME_NEDDYLATION

FBXO40 SKP2 FBXO30 CUL5 UBE2D1 UBE2D2 UBE2D3 ASB16

4.55e-042451048M27822
PathwayREACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE

MCM8 MCM6 SKP2 UBE2D1 UBE2E1

5.31e-04901045MM15371
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

UBE2D1 UBE2D2 UBE2D3

5.42e-04221043MM15675
PathwayREACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE

MCM8 MCM6 SKP2 UBE2D1 UBE2E1

5.87e-04921045M27666
PathwayREACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1

UBE2D1 UBE2D2 UBE2D3

6.20e-04231043M1003
PathwayREACTOME_TNF_SIGNALING

UBE2D1 UBE2D2 UBE2D3 SMPD3

7.65e-04561044MM15453
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

UBA5 FBXO40 SKP2 FBXO30 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 ASB16 TRIM50 SIGLEC1 LNX1 UBE2E3

7.96e-0471910414MM14540
PathwayREACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1

UBE2D1 UBE2D2 UBE2D3

7.97e-04251043MM15646
PathwayREACTOME_TNF_SIGNALING

UBE2D1 UBE2D2 UBE2D3 SMPD3

8.18e-04571044M27713
PathwayREACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS

UBE2D1 UBE2D2 UBE2D3 UBE2E1

9.32e-04591044M27763
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2E1 AOC2 NCOA1 CYP4F12 CYP4F11

1.02e-031041045M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2E1 AOC2 NCOA1 CYP4F12 CYP4F11

1.07e-031051045MM14842
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2E1 NCOA1 CYP4F12 CYP4F11

1.26e-03641044M5650
PathwayREACTOME_NEDDYLATION

FBXO40 SKP2 FBXO30 UBE2D1 UBE2D2 UBE2D3 ASB16

1.41e-032261047MM15543
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2E1 NCOA1 CYP4F12 CYP4F11

1.42e-03661044MM14839
PathwayWP_BIOSYNTHESIS_AND_TURNOVER_OF_1DEOXYSPHINGOID_BASES

SGPP2 SGPP1

1.47e-0381042M45534
Pubmed

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

MID2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 MID1 TRIM50 UBE2E3

1.78e-1527150921143188
Pubmed

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

TRIM72 TRIM25 TRIM5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 MID1 RNF10 UBE2E3

2.53e-121491501219549727
Pubmed

In Vitro Analysis of E3 Ubiquitin Ligase Function.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

2.91e-117150534057440
Pubmed

The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.

STK36 UBE2D1 UBE2D2 UBE2D3 MID1

2.91e-117150525278022
Pubmed

Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

6.93e-1117150633650289
Pubmed

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

6.93e-1117150636563856
Pubmed

The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

7.73e-118150528972136
Pubmed

MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 MID1

7.73e-118150525207814
Pubmed

Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

7.73e-118150529323787
Pubmed

Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

1.73e-109150532049508
Pubmed

Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.

UBE2D1 UBE2D2 UBE2D3 UBE2D4 RNF216

3.46e-1010150531087003
Pubmed

E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

3.46e-1010150521518764
Pubmed

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

5.53e-1023150630017913
Pubmed

A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

6.31e-1011150536027913
Pubmed

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

6.31e-1011150519712108
Pubmed

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

7.35e-1024150624647965
Pubmed

E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

1.08e-0912150522069333
Pubmed

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

UBE2D1 UBE2D2 UBE2D3 UBE2D4 RNF10

1.08e-0912150524211586
Pubmed

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.25e-0926150620061386
Pubmed

ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.66e-095150416413270
Pubmed

E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.66e-095150415684077
Pubmed

RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination.

RNF220 UBE2D3 UBE2E1 UBE2E3

1.66e-095150420170641
Pubmed

Cbl interacts with multiple E2s in vitro and in cells.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

1.75e-0913150531120930
Pubmed

Ubiquitination of STING at lysine 224 controls IRF3 activation.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

1.75e-0913150528763789
Pubmed

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

2.71e-0914150536481767
Pubmed

Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

4.05e-0915150532265276
Pubmed

Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

4.95e-096150428625874
Pubmed

h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

4.95e-096150416549277
Pubmed

The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.

TRIM72 UBE2D1 UBE2D2 UBE2D3

4.95e-096150425701873
Pubmed

NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

4.95e-096150433962630
Pubmed

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

4.95e-096150430404641
Pubmed

HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

UBA5 SKP2 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

5.70e-0990150835671810
Pubmed

Measuring rates of ubiquitin chain formation as a functional readout of ligase activity.

TRIM25 UBE2D1 UBE2D2 UBE2D3

1.15e-087150422350887
Pubmed

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.15e-087150424831002
Pubmed

Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.15e-087150430884854
Pubmed

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.15e-087150421685362
Pubmed

RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.15e-087150420553626
Pubmed

The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.15e-087150433282879
Pubmed

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

1.55e-0819150527425610
Pubmed

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.

UBE2D2 UBE2D3 UBE2E1 UBE2D4

2.30e-088150428681414
Pubmed

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.30e-088150423560854
Pubmed

Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

2.30e-088150418838541
Pubmed

A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

2.30e-088150416682404
Pubmed

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

2.30e-088150415247280
Pubmed

Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

4.12e-089150426711259
Pubmed

Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.

MCM6 UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.55e-0824150534195792
Pubmed

Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

6.84e-0810150428757353
Pubmed

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

6.92e-0825150517597759
Pubmed

Identification of a family of closely related human ubiquitin conjugating enzymes.

UBE2D1 UBE2D2 UBE2D3

7.86e-08315038530467
Pubmed

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.

CUL5 UBE2D1 UBE2D2 UBE2D3

1.07e-0711150424438103
Pubmed

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.60e-0712150424905733
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

UBA5 TRIM25 RNF220 UBE2D2 UBE2D3 RNF10 RNF216

1.94e-0795150729643511
Pubmed

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

UBE2D1 UBE2D2 UBE2D3 UBE2E1 LNX1

2.56e-0732150520864041
Pubmed

Physical and functional interactions between ZIP kinase and UbcH5.

UBE2D1 UBE2D2 UBE2D3

3.14e-074150318515077
Pubmed

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

3.22e-0714150414690596
Pubmed

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

TRIM25 TRIM5 UBE2D1 UBE2D2 UBE2E1 MID1 RNF10

3.85e-07105150722493164
Pubmed

Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.

UBE2D2 UBE2D3 UBE2E1 UBE2E3

4.37e-0715150417452440
Pubmed

E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.

UBE2D2 UBE2D3 UBE2E1 UBE2E3

4.37e-0715150421965653
Pubmed

E3-independent monoubiquitination of ubiquitin-binding proteins.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

4.37e-0715150417588522
Pubmed

MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis.

UBE2D1 UBE2D3 UBE2E1

7.81e-075150316522193
Pubmed

Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

UBE2D1 UBE2D2 UBE2D3

7.81e-075150326502057
Pubmed

The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.

UBE2D1 UBE2D2 UBE2D3

7.81e-075150331929179
Pubmed

RING E3-Catalyzed E2 Self-Ubiquitination Attenuates the Activity of Ube2E Ubiquitin-Conjugating Enzymes.

UBE2D2 UBE2E1 UBE2E3

7.81e-075150325960396
Pubmed

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

UBE2D1 UBE2D2 UBE2D3

7.81e-075150323509263
Pubmed

An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.

UBE2D2 UBE2E1 UBE2E3

7.81e-075150315001359
Pubmed

Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex.

UBE2D2 UBE2E1 UBE2E3

7.81e-075150311823428
Pubmed

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.

UBE2D1 UBE2D2 UBE2D3

7.81e-075150325327252
Pubmed

The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.

UBE2D1 UBE2D2 UBE2D3

7.81e-075150314562029
Pubmed

Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.

UBE2D1 UBE2D2 UBE2D3

7.81e-075150323408431
Pubmed

Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.

UBE2D1 UBE2D2 UBE2D3

7.81e-075150319741096
Pubmed

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

UBE2D1 UBE2D2 UBE2D3

7.81e-07515038090726
Pubmed

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

MID2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

8.52e-07118150719690564
Pubmed

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.

UBE2D2 UBE2D3 UBE2E1

1.56e-06615039990509
Pubmed

Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.

UBE2D1 UBE2D3 UBE2E1

1.56e-066150315930137
Pubmed

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.

UBE2D1 UBE2D2 UBE2D3

1.56e-066150327678051
Pubmed

Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation.

UBE2D1 UBE2D3 UBE2E1

1.56e-066150323131556
Pubmed

The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity.

UBE2D1 UBE2D2 UBE2E1

1.56e-066150324393003
Pubmed

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.

UBE2D1 UBE2D2 UBE2D3

1.56e-066150322124327
Pubmed

The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.

UBE2D2 UBE2E1 UBE2E3

1.56e-066150320484052
Pubmed

Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes.

UBE2D1 UBE2E1 UBE2E3

1.56e-066150311274149
Pubmed

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

UBE2D1 UBE2D2 UBE2D3

1.56e-066150315280377
Pubmed

N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.

UBE2D1 UBE2E1 UBE2E3

1.56e-066150311322894
Pubmed

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.88e-0621150421113135
Pubmed

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.

UBE2D1 UBE2D2 UBE2D3

2.72e-067150320051513
Pubmed

A ubiquitin ligase complex assembles linear polyubiquitin chains.

UBE2D1 UBE2D2 UBE2D3

2.72e-067150317006537
Pubmed

Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.

UBE2D2 UBE2D3 MID1

2.72e-067150322613722
Pubmed

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.

UBE2D1 UBE2D2 UBE2D3

2.72e-067150317719635
Pubmed

Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity.

TRIM25 UBE2D1 UBE2E1

2.72e-067150331028095
Pubmed

Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.

UBE2D1 UBE2D2 UBE2D3

2.72e-067150320347421
Pubmed

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

UBE2D1 UBE2D2 UBE2E1

2.72e-067150316337426
Pubmed

Autoubiquitylation of the V(D)J recombinase protein RAG1.

UBE2D1 UBE2D2 UBE2E1

4.33e-068150314671314
Pubmed

E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.

UBE2D2 UBE2D3 UBE2E1

4.33e-068150324446487
Pubmed

Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.

UBE2D2 UBE2D3 UBE2E1

4.33e-068150317462600
Pubmed

Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

UBE2D1 UBE2D2 UBE2D3

4.33e-068150314661060
Pubmed

The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.

UBE2D1 UBE2D2 UBE2D3

4.33e-068150312670957
Pubmed

The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation.

TRIM25 UBE2D3 UBE2E1

4.33e-068150325172487
Pubmed

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.40e-0627150430097011
Pubmed

The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.

MED16 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

5.57e-06102150637024974
Pubmed

Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.

UBE2D1 UBE2D2 UBE2D3

6.48e-069150312525502
Pubmed

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.

UBE2D1 UBE2D2 UBE2E1

6.48e-069150335114100
InteractionARK2C interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

9.82e-11121426int:ARK2C
InteractionUBTD1 interactions

MID2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 MID1 RNF10 TRIM50

3.17e-10401428int:UBTD1
InteractionTRIM50 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 TRIM50 LNX1 UBE2E3

1.76e-09491428int:TRIM50
InteractionTRIM45 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ZBTB40 UBE2E3

2.72e-09331427int:TRIM45
InteractionRNF150 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

3.93e-09201426int:RNF150
InteractionUBOX5 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.01e-08231426int:UBOX5
InteractionMID1 interactions

STK36 MID2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 MID1 LNX1 UBE2E3

1.21e-0811914210int:MID1
InteractionUBE2D4 interactions

TRIM25 MID2 TRIM5 UBE2D3 UBE2D4 MID1 RNF10 RNF216 TRIM50 LNX1

1.21e-0811914210int:UBE2D4
InteractionUBE2D3 interactions

TRIM25 MID2 TRIM58 YTHDC1 TRIM5 RNF220 UBE2D1 UBE2D2 UBE2D3 UBE2D4 MID1 RNF10 RNF216 TRIM50

1.35e-0828314214int:UBE2D3
InteractionRNF103 interactions

YTHDC1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

4.57e-08291426int:RNF103
InteractionCADPS2 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

5.68e-08301426int:CADPS2
InteractionRNF122 interactions

YTHDC1 UBE2D1 UBE2D2 UBE2D3 UBE2E1

6.64e-08161425int:RNF122
InteractionRNF167 interactions

IL17RC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

9.98e-08541427int:RNF167
InteractionZNRF1 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.80e-07361426int:ZNRF1
InteractionCHFR interactions

TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

2.10e-07601427int:CHFR
InteractionTOPORS interactions

WDR19 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3 TP53BP1

3.92e-07961428int:TOPORS
InteractionUBE2D2 interactions

UBA5 TRIM25 MID2 TRIM5 RNF220 UBE2D1 UBE2D2 UBE2D3 MID1 RNF10 RNF216 TRIM50 LNX1

4.14e-0731814213int:UBE2D2
InteractionRNF25 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

5.41e-07431426int:RNF25
InteractionTRIM38 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

9.32e-07471426int:TRIM38
InteractionZNRF2 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

9.32e-07471426int:ZNRF2
InteractionPOLM interactions

YTHDC1 UBE2D1 UBE2D2 UBE2D3 UBE2E1

9.45e-07261425int:POLM
InteractionRMND5B interactions

TRIM25 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.20e-06491426int:RMND5B
InteractionRNF14 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.20e-06491426int:RNF14
InteractionRFWD3 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3 PRIMPOL

1.54e-06801427int:RFWD3
InteractionRNF216 interactions

TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 RNF216

1.72e-06521426int:RNF216
InteractionTRIM2 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.92e-06531426int:TRIM2
InteractionUBE2L3 interactions

UBA5 TRIM25 SKP2 CUL5 RNF220 UBE2D2 MID1 NCOA1 RNF216 TP53BP1

2.56e-0621114210int:UBE2L3
InteractionRNF10 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF10 UBE2E3

2.71e-06871427int:RNF10
InteractionTRIM62 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3

2.80e-06321425int:TRIM62
InteractionBIRC8 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

2.80e-06321425int:BIRC8
InteractionMID2 interactions

MID2 IQCN UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 MID1 LNX1 METTL17 UBE2E3

3.10e-0626714211int:MID2
InteractionMGRN1 interactions

PDCD2 EDN3 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

3.41e-06901427int:MGRN1
InteractionTRIM17 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

3.82e-06341425int:TRIM17
InteractionRNF13 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

4.03e-06601426int:RNF13
InteractionDTX1 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

4.43e-06351425int:DTX1
InteractionRBCK1 interactions

TRIM25 ZFAND2B BACH1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 LNX1 XPOT

4.45e-061761429int:RBCK1
InteractionUVSSA interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

5.88e-06371425int:UVSSA
InteractionCNOT4 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

6.46e-06651426int:CNOT4
InteractionMUL1 interactions

STK36 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

7.36e-061011427int:MUL1
InteractionUBE2D1 interactions

TRIM72 TRIM25 MID2 TRIM5 UBE2D1 UBE2D2 UBE2D3 MID1 RNF10 RNF216 TRIM50

7.76e-0629414211int:UBE2D1
InteractionDTX3L interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

8.41e-06681426int:DTX3L
InteractionTRIM32 interactions

TRIM72 MID2 TRIM5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 ARMC5 UBE2E3

9.39e-061931429int:TRIM32
InteractionRNF220 interactions

TRIM25 RNF220 UBE2D2 UBE2D3 UBE2E3

1.12e-05421425int:RNF220
InteractionTRIM39 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 LNX1 UBE2E3

1.15e-051081427int:TRIM39
InteractionUFM1 interactions

UBA5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.93e-051171427int:UFM1
InteractionTRIM3 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 LNX1

2.15e-05801426int:TRIM3
InteractionTRIM10 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 LNX1

2.17e-05481425int:TRIM10
InteractionDEF8 interactions

TRIM25 MCM8 ATG2B RADIL RAD17

2.93e-05511425int:DEF8
InteractionRNF5 interactions

GPR35 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

3.12e-051261427int:RNF5
InteractionAREL1 interactions

MFSD4A UBE2D1 UBE2D2 UBE2D3

3.66e-05271424int:AREL1
InteractionRNPEP interactions

TRIM25 GPR160 GLA RNPEP ARMC5

3.88e-05541425int:RNPEP
InteractionRNF114 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

4.49e-05911426int:RNF114
InteractionRNF166 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

4.49e-05911426int:RNF166
InteractionRNF34 interactions

TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2E1

4.63e-05561425int:RNF34
InteractionAMFR interactions

WIPI1 TRIM25 CYP2E1 MFSD4A GPR55 UBE2D1 UBE2D2 UBE2D3 UBE2D4

4.76e-052371429int:AMFR
InteractionRNF126 interactions

SKP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 XPOT

5.59e-051381427int:RNF126
InteractionWSB1 interactions

TRIM25 CUL5 UBE2D2 UBE2D3

6.41e-05311424int:WSB1
InteractionRNF111 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

6.43e-05971426int:RNF111
InteractionRNF26 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

6.47e-05601425int:RNF26
InteractionTRIM27 interactions

MID2 IQCN CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 BRF1 UBE2D4 NCOA1 TRIM50 LNX1 UBE2E3

7.24e-0551414213int:TRIM27
InteractionTRIM8 interactions

TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 LNX1

7.62e-051001426int:TRIM8
InteractionUBA1 interactions

DENND4A TRIM25 GART UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNPEP ARMC5 UBE2E3

8.15e-0538014211int:UBA1
InteractionTRIM35 interactions

TRIM5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 RAD17

8.98e-051031426int:TRIM35
InteractionUBE2K interactions

UBA5 MID2 TRIM5 UBE2D2 UBE2D3 MID1 TRIM50

9.06e-051491427int:UBE2K
InteractionDTX3 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.17e-041081426int:DTX3
InteractionUBE4A interactions

CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 TP53BP1

1.23e-041091426int:UBE4A
InteractionMKRN3 interactions

TRIM5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 ARMC5 UBE2E3

1.24e-042101428int:MKRN3
InteractionZNRF4 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.29e-041101426int:ZNRF4
InteractionRNF185 interactions

SGPP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.31e-041581427int:RNF185
InteractionRNF181 interactions

ZFAND2B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

1.41e-041601427int:RNF181
InteractionN4BP1 interactions

TRIM25 TRIM5 MID1 MARF1

1.45e-04381424int:N4BP1
InteractionPRSS41 interactions

RHOBTB1 TPSG1

1.47e-0431422int:PRSS41
InteractionNKD2 interactions

MED16 UBE2D2 LNX1 UBE2E3

1.77e-04401424int:NKD2
InteractionPSG8 interactions

FAT4 MCM8 RHOBTB1 CELSR3

1.95e-04411424int:PSG8
InteractionRNF11 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 RNF216 UBE2E3

1.98e-041691427int:RNF11
InteractionANAPC11 interactions

TRIM25 CUL5 UBE2D1 UBE2D2 UBE2D3

2.26e-04781425int:ANAPC11
InteractionGMNN interactions

MID2 CTC1 MCM6 SKP2 MID1 LNX1

2.28e-041221426int:GMNN
InteractionMARCHF3 interactions

UBE2D2 UBE2D3 UBE2E1 UBE2D4

2.36e-04431424int:MARCHF3
InteractionSHLD2 interactions

TRIM25 BACH1 RECQL CUL5

2.36e-04431424int:SHLD2
InteractionPJA1 interactions

MYO9B IQCN SKP2 UBE2D2 UBE2D3 UBE2E3

2.38e-041231426int:PJA1
InteractionUBE2V1 interactions

TRIM25 TRIM5 UBE2D1 UBE2D2 MID1 RNF10

2.49e-041241426int:UBE2V1
InteractionGPR160 interactions

GPR160 RNPEP

2.93e-0441422int:GPR160
InteractionDZIP3 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 LNX1 UBE2E3

3.22e-041831427int:DZIP3
InteractionUBE2E3 interactions

MID2 RNF220 MID1 RNF10 TRIM50 UBE2E3

3.48e-041321426int:UBE2E3
InteractionHERC5 interactions

UBA5 SKP2 CUL5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3

3.52e-042451428int:HERC5
InteractionSYTL2 interactions

RPAP1 NCOA1 LNX1

3.58e-04201423int:SYTL2
InteractionBFAR interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

3.61e-04481424int:BFAR
InteractionRNF115 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

3.77e-041341426int:RNF115
InteractionLRSAM1 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4

3.97e-04881425int:LRSAM1
InteractionHSD17B7P2 interactions

EME1 DENND4A MCM8

4.15e-04211423int:HSD17B7P2
InteractionTNFAIP3 interactions

MED16 MCM6 TRIM5 UBE2D1 UBE2D3 RNF216 LNX1

4.17e-041911427int:TNFAIP3
InteractionTRIM5 interactions

TRIM5 UBE2D1 UBE2D2 UBE2D3 UBE2D4

4.63e-04911425int:TRIM5
InteractionATG2B interactions

WIPI1 ATG2B MCM6 YTHDC1 SKP2

4.63e-04911425int:ATG2B
InteractionBARD1 interactions

MCM6 TRAPPC8 SKP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 TP53BP1

4.83e-043231429int:BARD1
InteractionCRB2 interactions

TP53BP1 CRB2

4.86e-0451422int:CRB2
InteractionTRIM43 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.29e-04531424int:TRIM43
InteractionRNF125 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.29e-04531424int:RNF125
InteractionATRIP interactions

MID2 MCM6 LNX1 TP53BP1 RAD17

5.64e-04951425int:ATRIP
InteractionOTUB2 interactions

TRIM25 MID2 TRAPPC8 TRIM5 MID1

5.92e-04961425int:OTUB2
InteractionRNF168 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2E1 TP53BP1

6.50e-04981425int:RNF168
Cytoband19p13.1

MYO9B IQCN CYP4F12 CYP4F11

1.90e-0548150419p13.1
GeneFamilyRing finger proteins

TRIM72 TRIM25 MID2 TRIM58 TRIM5 RNF220 MID1 RNF10 RNF216 TRIM50 RNF180 LNX1

1.68e-072751141258
GeneFamilyUbiquitin conjugating enzymes E2

UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2D4 UBE2E3

2.07e-07411146102
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM72 TRIM25 MID2 TRIM58 TRIM5 MID1 TRIM50

2.30e-0695114759
GeneFamilySphingosine-1-phosphate phosphatases

SGPP2 SGPP1

3.94e-05211421070
GeneFamilyMCM family

MCM8 MCM6

1.38e-03911421085
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMB4 COBLL1 SGPP2 MFSD4A LRP1B ARHGAP6 TRIM50 LNX1

2.38e-071891488f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP2 COBLL1 SFMBT2 ALAD SMPD3 NNMT CRB2

2.52e-061811487330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP2 COBLL1 SFMBT2 ALAD SMPD3 NNMT CRB2

2.52e-0618114873f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMB4 COBLL1 SGPP2 MFSD4A LRP1B ARHGAP6 LNX1

3.23e-0618814873cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

MYO9B BACH1 DENND4C ARHGEF10L IRAK3 SIGLEC1 PIK3R5

3.85e-061931487cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9B SFMBT2 DENND4C GSN IRAK3 SIGLEC1 PIK3R5

3.98e-06194148745708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

XCR1 SFMBT2 DENND4C GSN IRAK3 SIGLEC1 PIK3R5

4.12e-061951487247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_pDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TRIM58 COBLL1 CPXM1 SMPD3 CRB2 CDHR4

2.04e-0516714868ddf9da71a7c4ed53588435db826563a24cee616
ToppCellmetastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

EME1 GSN FCGBP CACNA1G SMPD3 PPM1N

2.41e-05172148638d17e769fe8eac8b57b820490d4ddd969243ee7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COBLL1 DNAH14 RHOBTB1 OTOGL SNTG1 UBE2E3

2.49e-0517314868335b77f730ed43fc348a005566e73a103c6774b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COBLL1 DNAH14 RHOBTB1 OTOGL SNTG1 UBE2E3

2.57e-051741486b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COBLL1 DNAH14 RHOBTB1 OTOGL SNTG1 UBE2E3

3.01e-0517914868766a5a066091879f521acfc612abf563ff78808
ToppCellwk_20-22-Hematologic-Meg-ery-Definitive_erythroblast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DENND4A TRIM58 ATG2B FBXO30 RNF10 ALAD

3.30e-0518214860c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCellfacs-Skin-Telogen-3m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C10orf90 IL17RC DENND4C GPR160 SGPP1 SUSD2

3.41e-051831486ed1e0b07475f9951728682ed70b85367cf2a744d
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SFRP2 SUSD2 CPXM1 ALAD SMPD3 CRB2

3.41e-051831486274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 MFSD4A LRP1B DNAH14 ARHGAP6 LNX1

3.62e-051851486898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCellCOVID-19-kidney-Mito-rich_Distal|kidney / Disease (COVID-19 only), tissue and cell type

COBLL1 SGPP2 MFSD4A LRP1B ARHGAP6 LNX1

3.84e-0518714862ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 MFSD4A TACC2 ARHGAP6 TRIM50 LNX1

3.96e-051881486bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 MFSD4A TACC2 ARHGAP6 TRIM50 LNX1

3.96e-051881486eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

COBLL1 SGPP2 LRP1B ARHGEF10L SGPP1 MID1

3.96e-0518814868f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 LRP1B ARHGEF10L SGPP1 MID1 SNTG1

3.96e-0518814864154f4787483c7e076e87a187733a9f666742c3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 LRP1B ARHGEF10L SGPP1 MID1 SNTG1

4.08e-05189148690aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 SLC43A3 GSN CPXM1 SMPD3 NNMT

4.08e-051891486bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 MFSD4A LRP1B ARHGAP6 TRIM50 LNX1

4.20e-051901486b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 SLC43A3 GSN CPXM1 SMPD3 NNMT

4.20e-051901486f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 SLC43A3 GSN CPXM1 SMPD3 NNMT

4.20e-051901486c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

MYO9B SFMBT2 ARHGEF10L IRAK3 SIGLEC1 PIK3R5

4.32e-051911486dab953682b8c9ed680a799161f837f792a7e4f33
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC43A3 GSN SNTG1 CPXM1 SMPD3 NNMT

4.45e-051921486853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC43A3 GSN SNTG1 CPXM1 SMPD3 NNMT

4.45e-05192148649281626ecad0456fdbded2378b7028d7b589686
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A MYO9B COBLL1 BACH1 RALGAPB FCRL1

4.58e-05193148608696a99309f5b088692ddac8cca35413b5e810d
ToppCellfacs-Heart-LA-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 SLC43A3 GSN SNTG1 AHSG CPXM1

4.58e-051931486124364adb3ded77282d449dd2cb039e6f2403a39
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-conventional_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

XCR1 ATP13A5 GSN MTMR14 NEGR1 CACNA1G

4.58e-051931486984ea5b871479527ab57dd813bacae844c0d8c06
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DENND4A TRIM58 ATG2B FBXO30 RNF10 CYP4F12

4.58e-051931486be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-conventional_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

XCR1 ATP13A5 GSN MTMR14 NEGR1 CACNA1G

4.58e-051931486529281b912070c8655e38880ac73f5e4bd6ee4ce
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO9B BACH1 ARHGEF10L IRAK3 SIGLEC1 PIK3R5

4.72e-05194148669cf7c989ac355c459db13f9d4267b55adc3c174
ToppCellfacs-Heart-LA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 SLC43A3 GSN SNTG1 AHSG CPXM1

4.72e-05194148634b54bea013c8c724fadae357e29953c291bfce1
ToppCellfacs-Heart-LA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 SLC43A3 GSN SNTG1 AHSG CPXM1

4.72e-0519414869a5dd7ae6de72a000cf9a0d42f6b0884fa43f345
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

MYO9B BACH1 ARHGEF10L IRAK3 SIGLEC1 PIK3R5

4.85e-051951486148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)|Adult / Lineage, Cell type, age group and donor

MYO9B BACH1 ARHGEF10L IRAK3 SIGLEC1 PIK3R5

4.85e-05195148655e25f702af19146a161861cfd15f40bbda1dc35
ToppCellMild/Remission-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TUT4 IQCN EDN3 FCRL1 MARF1

5.26e-05121148568940a552233d255b90ce5a081339c0d9d46ab02
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9B SFMBT2 ARHGEF10L FCRL1 SIGLEC1 PIK3R5

5.28e-051981486e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCellControl_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|Control_saline / Treatment groups by lineage, cell group, cell type

DENND4A TRIM58 GPR160 FBXO30 RNF10 ALAD

5.28e-051981486dd80fd9671ee863aebcf4c1023d3e004cc2ee709
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP2 SLC43A3 LRP1B GSN NEGR1 NNMT

5.28e-051981486abac765c4f6864bdb1700bc546c3b9771edc25c3
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9B SFMBT2 ARHGEF10L FCRL1 SIGLEC1 PIK3R5

5.28e-0519814860baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP2 SLC43A3 LRP1B GSN NEGR1 NNMT

5.28e-051981486ff57addcbdd53e5d2d0c80ec76b5eab3b3a67ca2
ToppCell3'-Adult-LymphNode-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP2 SLC43A3 LRP1B GSN NEGR1 NNMT

5.28e-051981486698166b4ca173176ed563af6a1efc8c7d0a18e0b
ToppCellremission-unassigned|World / disease stage, cell group and cell class

XCR1 MID2 CYP2E1 TACC2 NEGR1

1.69e-041551485d81bec894381e3e2d6249a567e8108b8423e5c54
ToppCellCOVID-19-APC-like-Monocytes|COVID-19 / group, cell type (main and fine annotations)

MCM8 RADIL RPAP1 RNPEP NFKBIE

1.85e-041581485a0d94bd067424783863a48db20976d4c2043600c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PKDCC RADIL NEGR1 IRAK3 SMPD3

1.90e-041591485e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM25 GPR55 GSN FCGBP TPSG1

1.90e-041591485c9e093d7c1dca83f6546adaf3d874929e2cea612
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PKDCC RADIL NEGR1 IRAK3 SMPD3

1.90e-0415914852607b562903228274fbd96168ba826782fab0b53
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGPP2 MFSD4A FCRL1 DDX25 PRIMPOL

1.90e-04159148574655c22e9fdd88e3052b9dfb954c8fb678bd2d8
ToppCellNS-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GFRA3 ARHGAP6 RADIL NEGR1 CPXM1

1.96e-0416014858a4746463ca1976f7d6de803496c851249ced797
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATP13A5 LRP1B SFMBT2 OTOGL SIGLEC1

2.08e-041621485bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TRIM72 TRIM58 GPR55 CELSR3 NEGR1

2.08e-041621485ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCellfacs-Marrow-T_cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XCR1 GPR35 BACH1 ARHGEF10L NEGR1

2.14e-04163148530cd95d4f37bd54c1fde54960cb005db58bdd30c
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A MYO9B COBLL1 BACH1 FCRL1

2.14e-0416314856bed27d2f67a430a847da5eb47878d14b4949c45
ToppCellfacs-Marrow-T_cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XCR1 GPR35 BACH1 ARHGEF10L NEGR1

2.14e-041631485ab934cb986495adfc8dbe5a276577f2a8fb6ee03
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 ARHGEF10L SGPP1 MID1 SNTG1

2.20e-0416414856fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellBAL-Mild-cDC_11|Mild / Compartment, Disease Groups and Clusters

XCR1 TRIM58 MBOAT4 CPXM1 NNMT

2.20e-0416414854bd9629d054545d1e3f9e5c127b5ac2388637106
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

WDR27 MCM6 WDR19 NEGR1 CRB2

2.26e-0416514858728f927502e56f2768b4224e9111939d3d7815a
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-1|TCGA-Ovary / Sample_Type by Project: Shred V9

SKP2 EDN3 GFRA3 DDX25 UBE2E3

2.26e-0416514852ca1154a8692af311d99a4d3aa2f2ac3d23a4310
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SFRP2 PKDCC SNTG1 SMPD3 CRB2

2.39e-041671485743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SFRP2 PKDCC SNTG1 SMPD3 CRB2

2.39e-0416714851adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCC5 RADIL RNF180 PRIMPOL CDHR4

2.46e-0416814851bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCC5 RADIL RNF180 PRIMPOL CDHR4

2.46e-04168148569f534de0f9a293047bea03cb1b78551087a8df5
ToppCell390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|390C / Donor, Lineage, Cell class and subclass (all cells)

GSN DLGAP3 FCGBP ASB16 SIGLEC1

2.53e-0416914852c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

XCR1 MBOAT4 GPR160 NEGR1 CPXM1

2.53e-041691485e3410ccb3f85811c75694e286115803911169a2f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 LRP1B SGPP1 MID1 SNTG1

2.53e-0416914850332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

XCR1 MBOAT4 GPR160 NEGR1 CPXM1

2.53e-041691485a4f610d07c3ba5537f4497f523669b914f7eddc1
ToppCellmetastatic_Brain-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

SGPP1 FCSK RPAP1 IRAK3 PIK3R5

2.67e-0417114850d14bc9688c427ba2265984987dc3eea195b19eb
ToppCelldroplet-Fat-Scat-18m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 GPR35 ARHGEF10L RNPEP CPXM1

2.74e-0417214858a4a5ad65eec92ce4fa45c5aa01c28666307455b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A COBLL1 BACH1 CNPPD1 FCRL1

2.81e-041731485d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COBLL1 RHOBTB1 OTOGL SNTG1 UBE2E3

2.81e-0417314859a2d42f8d9cb834856522661d524abb91c4637c5
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A USP16 DENND4C SNTG1 XPOT

2.89e-041741485f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellCOPD-Myeloid-pDC|World / Disease state, Lineage and Cell class

MROH9 CTC1 COBLL1 BRF1 SMPD3

2.89e-041741485be8227398300711ccda5ecc41ad34064bb246b19
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP2 AOC2 PKDCC SUSD2 NNMT

2.89e-0417414854da79da7a09ee1e345102c5331675ebcdbe56171
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MFSD4A LRP1B DNAH14 ARHGAP6 LNX1

2.97e-041751485e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A COBLL1 SGPP2 RNF216 IRAK3

3.13e-041771485c2b8a3a149d70f77612759dea34df9e43953c566
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A COBLL1 SGPP2 RNF216 IRAK3

3.13e-041771485384f841aa7b2d05815af7885e481f5affc55d897
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XCR1 SFMBT2 EDN3 GFRA3 C8B

3.13e-0417714851dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCellfacs-Thymus-Epithelium-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A COBLL1 SGPP2 RNF216 IRAK3

3.13e-0417714850e9e44119653abfd270e602e5e477a15e774638f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XCR1 SFMBT2 EDN3 GFRA3 C8B

3.13e-041771485426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP2 SUSD2 SMPD3 NNMT PPM1N

3.21e-041781485a107dd98a07086ed0429116095ecda60c9dbef1e
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

XCR1 ATG2B MTMR14 NEGR1 PIK3R5

3.29e-04179148599894067e2c2a3ed53abdc5434410c3172693496
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C10orf90 WDR19 SUSD2 SMPD3 PPM1N

3.29e-041791485adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCellmetastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs|metastatic_Brain / Location, Cell class and cell subclass

GSN FCGBP CACNA1G SMPD3 PPM1N

3.38e-04180148551727cb66fe7a7709453f7026e0ff3d6c93d5aa5
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBXO40 C10orf90 DLGAP3 AHSG CPXM1

3.38e-04180148539ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SFRP2 SUSD2 ALAD SMPD3 CRB2

3.38e-0418014852ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCelltumor_Lung-Myeloid_cells-CD207+CD1a+_LCs|tumor_Lung / Location, Cell class and cell subclass

GSN FCGBP GLA CACNA1G PPM1N

3.55e-041821485243779ba1009097f8fafa1a691e296ec3aeefc04
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCM8 ZFAND2B IL17RC CNPPD1 SUSD2

3.55e-0418214853fddadb2ff75013ec6eeb415872667a6bae1da2d
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP2 SUSD2 SMPD3 NNMT PPM1N

3.55e-0418214859966f42c338cbd471efa8ffc765a6ce93693aa75
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 MFSD4A LRP1B ARHGAP6 LNX1

3.64e-04183148531ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellfacs-Marrow-T-cells-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM72 UBA5 WIPI1 USP16 RHOBTB1

3.64e-041831485b0b835f3b1de1bd46a47e1b805aa8994cd3a4e3e
ToppCell3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MBOAT4 SFMBT2 GFRA3 CELSR3 BBS12

3.64e-04183148549f3ddc1c7c04b4ca837dbd6dad995add82941d6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 FAT4 LRP1B OTOGL OTOG

3.73e-0418414852cbed6462fea2622871bb7e49b0df3d984239281
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_11|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

XCR1 CYP2E1 MBOAT4 NEGR1 CPXM1

3.73e-041841485667846c422cfa27e949a24844a305df859cb6760
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3|lymph-node_spleen / Manually curated celltypes from each tissue

CYP2E1 PKDCC GSN RHOBTB1 NEGR1

3.73e-041841485479e60f76c191253e23699c9dd7ef7efc08c59ad
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 FAT4 LRP1B OTOGL OTOG

3.73e-041841485ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_11|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

XCR1 CYP2E1 MBOAT4 NEGR1 CPXM1

3.73e-041841485a6f8b42982ec0cf44b950a2cd9715d068eec4ecb
ComputationalGenes in the cancer module 4.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

1.62e-0521814MODULE_4
ComputationalGenes in the cancer module 82.

UBE2D1 UBE2D2 UBE2D3 UBE2E1

2.84e-0524814MODULE_82
ComputationalUbiquitin ligases.

GART UBE2D1 UBE2D2 UBE2E1

1.17e-0434814MODULE_278
ComputationalNeighborhood of MLL

DENND4A ATG2B WDR19 CUL5 CNPPD1 KAT6B METTL17

3.28e-04174817GCM_MLL
ComputationalNeighborhood of HPN

CYP2E1 AHSG CYP4F12 C8B NNMT CYP4F11

5.06e-04134816GNF2_HPN
ComputationalNeighborhood of HPX

CYP2E1 AHSG CYP4F12 C8B NNMT CYP4F11

5.27e-04135816GNF2_HPX
ComputationalGenes in the cancer module 233.

UBE2D1 UBE2D2 UBE2D3

5.73e-0422813MODULE_233
Diseasenuclear protein MDM1 measurement

ZFAND2B TRIM5

1.39e-0441432EFO_0802822
Diseaselow density lipoprotein cholesterol measurement, body mass index

COBLL1 MCM6

3.45e-0461432EFO_0004340, EFO_0004611
DiseaseOpitz GBBB syndrome (implicated_via_orthology)

MID2 MID1

3.45e-0461432DOID:0080697 (implicated_via_orthology)
Diseasebutyrylcholinesterase measurement

TRIM58 RNPEP

3.45e-0461432EFO_0004571
Diseaseglutamate measurement

BACH1 UBE2D3 OTOG

3.71e-04291433EFO_0010487
DiseaseC-C motif chemokine 1 measurement

MED16 C8B

4.82e-0471432EFO_0008041
Diseasefree cholesterol:total lipids ratio, intermediate density lipoprotein measurement

WIPI1 COBLL1 AHSG TP53BP1

8.25e-04861434EFO_0008595, EFO_0020945
Diseasethioredoxin domain-containing protein 12 measurement

TUT4 CELSR3 CDHR4

8.96e-04391433EFO_0008298
Diseasebilirubin measurement

FAT4 WIPI1 MYO9B SGPP2 RECQL TRIM5 CBLN2 PHIP

1.46e-034421438EFO_0004570
Diseasemicrophthalmia (implicated_via_orthology)

ARHGAP6 MID1

1.49e-03121432DOID:10629 (implicated_via_orthology)
DiseaseIntellectual Disability

UBA5 APC2 FCSK BRF1 ZBTB40 CACNA1G ELP2 PHIP

1.56e-034471438C3714756
Diseaseocular hypertension, response to triamcinolone acetonide

BACH1 IL17RC OTOGL

1.74e-03491433EFO_0006954, EFO_1001069
Diseaselower face morphology measurement

MROH9 SFRP2 LRP1B ZBTB40

1.98e-031091434EFO_0010948
Diseasesuperior frontal gyrus grey matter volume measurement

CCKAR SNTG1

2.04e-03141432EFO_0006516
DiseaseColorectal Carcinoma

SFRP2 APC2 ABCC5 FBXO30 ARHGEF10L CNPPD1 BRF1 RPAP1 PIK3R5 PHIP

2.29e-0370214310C0009402
Diseaseintelligence, self reported educational attainment

DENND4A CELSR3 NEGR1 HPS6

2.57e-031171434EFO_0004337, EFO_0004784
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

COBLL1 MCM6

3.02e-03171432EFO_0004611, EFO_0007800
Diseasetriglyceride measurement, body mass index

STK36 COBLL1

3.78e-03191432EFO_0004340, EFO_0004530
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

UBE2E1 RHOBTB1 C8B KAT6B

3.85e-031311434C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

UBE2E1 RHOBTB1 C8B KAT6B

3.85e-031311434C4552091
DiseaseJuvenile arthritis

UBE2E1 RHOBTB1 C8B KAT6B

3.85e-031311434C3495559
DiseaseJuvenile psoriatic arthritis

UBE2E1 RHOBTB1 C8B KAT6B

3.85e-031311434C3714758
DiseaseJuvenile-Onset Still Disease

UBE2E1 RHOBTB1 C8B KAT6B

4.29e-031351434C0087031
Diseaselung cancer

BACH1 PKDCC

4.61e-03211432MONDO_0008903
DiseaseProfound Mental Retardation

ZBTB40 CACNA1G ELP2 PHIP

4.75e-031391434C0020796
DiseaseMental Retardation, Psychosocial

ZBTB40 CACNA1G ELP2 PHIP

4.75e-031391434C0025363
DiseaseMental deficiency

ZBTB40 CACNA1G ELP2 PHIP

4.75e-031391434C0917816
Diseaseanorexia nervosa

SGPP2 CELSR3 PHIP

4.81e-03701433MONDO_0005351

Protein segments in the cluster

PeptideGeneStartEntry
CLEKDAALALPSLCP

BACH1

211

O14867
PILACCIPAFSSRAL

ARHGEF10L

781

Q9HCE6
ANCIPCPLQEADTVL

ATP13A5

61

Q4VNC0
ENPCLTFVTPCLLAG

RNPEP

301

Q9H4A4
FTQCDILPKPFCQLE

CUL5

101

Q93034
EAIPLCQALSCGLPE

CSMD2

2521

Q7Z408
CLLPSAFCPAQVLLG

CTC1

596

Q2NKJ3
IIVANEPLQPFLCKC

FAT4

3836

Q6V0I7
LEVLLNAYPCVPSCE

ASB16

366

Q96NS5
CLRAEILACPVSDPN

CPXM1

266

Q96SM3
VACNPACFITQLLPV

GLA

376

P06280
PEDRVACALTLPFIC

ARMC5

651

Q96C12
PPCELGLENETLFCL

CCKAR

16

P32238
ECVLPEPAFLCLLSA

CCNP

166

Q9H8S5
DISRIFTCCLPGLPE

BBS12

311

Q6ZW61
FAPVVSDLCSLPCFI

CDHR4

11

A6H8M9
ELAPIICSKCEFDPL

COBLL1

171

Q53SF7
VNALELFPQCLCLAP

DDX25

161

Q9UHL0
SQIQEPCCSDLFLFP

ATG2B

1441

Q96BY7
LCPLALADVLSAPCP

DENND4A

451

Q7Z401
LFPDFCLPALCLQTQ

RAD17

546

O75943
SLDPNCPRDLTDCLL

CYP2E1

256

P05181
ETQFPSCDNLVLCRP

IQCN

191

Q9H0B3
DQPRADPIPICSFCL

KAT6B

206

Q8WYB5
CLPALLECPPFQTER

RADIL

581

Q96JH8
DCLLCFPETLPESSL

C8orf76

211

Q96K31
SINPVACLPDLAACV

AOC2

731

O75106
FIFCDLPPLLKLSCG

OR9Q2

176

Q8NGE9
LVFLACCVAPTNPRF

MCM6

296

Q14566
FFCDIPPVLKLACTD

OR10S1

191

Q8NGN2
FCDIPAVLPLACKDT

OR10D4P

176

Q8NGN7
FCDIPPLLALSCSDT

OR5B21

176

A6NL26
FIFCDLPPLLKLTCG

OR9Q1

176

Q8NGQ5
DLPNPCLDLACEFLC

LRP1B

4171

Q9NZR2
CLLPSCLPAGQSVDF

NEGR1

26

Q7Z3B1
LCAACGEIQSFPLPD

MCM8

241

Q9UJA3
SPLIADPFLSEANCL

MFSD4A

156

Q8N468
FPDELPNSCLLAALS

MTMR14

581

Q8NCE2
PLLEVAVPAACACLL

CRB2

1221

Q5IJ48
TFPNLLVACDVCLCP

ALAD

111

P13716
APAVLLCCLALLPQE

NFKBIE

271

O00221
LPENVLAPCEDFLLF

FER1L4

416

A9Z1Z3
PQALACELCGRPLSF

PDCD2

46

Q16342
FCDLPPVLALSCSDT

OR5A1

181

Q8NGJ0
LSTLCLDAACPDLPT

NNMT

161

P40261
GLAPELLCAQLLDTC

PPM1N

296

Q8N819
CHICLQALLDPLDTP

LNX1

41

Q8TBB1
CLEVQTRCPFILPDN

NALF2

316

O75949
PPALLGELCAVLDSC

IRAK3

21

Q9Y616
FFCDIPPLLAISCSD

OR5C1

181

Q8NGR4
PLAACQALCTFLPLG

MROH9

396

Q5TGP6
DPCCLQLLCTALFTP

SMPD3

51

Q9NY59
NLAVADLCLLCTLPF

GPR35

61

Q9HC97
VQSPFPSLCTLVECL

GPR55

86

Q9Y2T6
ECCLLPSQLLIPSLD

MED16

716

Q9Y2X0
CCFIPLTIPNLEQIE

GPR160

316

Q9UJ42
LPPCNCDTLHRLLQF

ARHGAP6

511

O43182
CCLRPDLAILPSSDL

ABCC5

661

O15440
PEAPVEALVCNLDCL

FCSK

116

Q8N0W3
PALPAVFLCSSRCEE

APC2

2031

O95996
PQCLPSLANVSSCLE

CNPPD1

286

Q9BV87
CFLPENFSLPLSVDL

CACNA1G

241

O43497
PNCLELRRLCFSDPL

GFRA3

246

O60609
LALAPSTCPRCLFQE

EDN3

221

P14138
CQDCPLLAPLNDTRV

AHSG

146

P02765
DPQGPLKDCIFDLCL

FCGBP

3881

Q9Y6R7
LLLICAPLCEPAELF

FCRL1

6

Q96LA6
PVISRCCTQDFVLPD

CYP4F11

396

Q9HBI6
ATLPQCSLPELYACI

C9orf153

16

Q5TBE3
PFISRCCTQDIVLPD

CYP4F12

396

Q9HCS2
CSQDDDCLPLLATPA

DLGAP3

511

O95886
LLLPACCPVRAQNDT

CBLN2

41

Q8IUK8
ACPFCKSNFLPLLNI

DENND4C

1521

Q5VZ89
CLIRCNAPFPLLDAV

DNAH14

41

Q0VDD8
LLCPLEQVPCLNSEY

FBXO40

56

Q9UH90
VLQDAPACCLPLFKF

MARF1

886

Q9Y4F3
PAVCAVALLCSLAPQ

MBOAT4

66

Q96T53
DCNPLGSLPFLTCDV

LAMB4

456

A4D0S4
PAPALLCALSLALCA

GSN

6

P06396
LILDPCCQLPAYLST

EME1

161

Q96AY2
CLSFLPNTDVPILAC

ELP2

166

Q6IA86
VLPFDDNVCLREPCE

CELSR3

1371

Q9NYQ7
DLQSEFLCPCLGLTL

CT62

51

P0C5K7
LLCPFERVPCLNSDF

FBXO30

51

Q8TB52
ILPPFELLCQCLCQL

HPS6

561

Q86YV9
CFLCTALSQPPLVAV

ERVFC1

251

P60507
ELPCPQLTNLACSFS

METTL17

336

Q9H7H0
ACANVLTPDRIPEFC

C2CD4A

36

Q8NCU7
APVELFLLCAALGCL

C8B

11

P07358
LLDAPCSLPAEAALC

IL17RC

386

Q8NAC3
FKSDCFPLPAEVCLL

PRIMPOL

456

Q96LW4
EALACKFLPPVEGCL

OTOGL

1391

Q3ZCN5
IFCEPCLRTLAKDNP

RNF180

451

Q86T96
FGEVALLLPTKDPCC

OTOG

2486

Q6ZRI0
FLCCLPSQLPNICVE

NOXRED1

141

Q6NXP6
ECDRFPQDNDLCIPL

SFRP2

141

Q96HF1
DQLPNFLEELPDCPC

SUSD2

301

Q9UGT4
FLEELPDCPCTLTQA

SUSD2

306

Q9UGT4
ILPVCLPEASDDFCP

TPSG1

141

Q9NRR2
DCILEFPARNFTLPC

PKDCC

311

Q504Y2
LKLPLNEDCACAPSD

SNTG1

146

Q9NSN8
DQCISSQLDELLCPP

NCOA1

906

Q15788
ITIPLACKIFNIPCD

SGPP1

386

Q9BX95
CLGFALCASVPILPL

SLC43A3

376

Q8NBI5
ELVRCPSCSFPALLD

RNF216

601

Q9NWF9
IEEATTPCPFCKFLL

WDR19

1246

Q8NEZ3
TPCPFCKFLLPECEL

WDR19

1251

Q8NEZ3
AACLLDNPLCADVLF

RHOBTB1

256

O94844
LFDSQAPICPICQVL

RNF220

216

Q5VTB9
LPQACQPEELLCFSC

STARD9

4106

Q9P2P6
APLTLLCNPDFCQRI

STK36

436

Q9NRP7
CLDSASPLFPVCVIV

SGPP2

241

Q8IWX5
ILFPGFLCPLQDVCA

C10orf90

481

Q96M02
PALCSDGFTLVICPL

RECQL

126

P46063
PDELLLGIFSCLCLP

SKP2

101

Q13309
PICLELLTQPLSLDC

TRIM5

16

Q9C035
LNLCLSDLVFACLLP

XCR1

71

P46094
ICSLLCDPNPDDPLV

UBE2D2

106

P62837
FPEILDLAPFCTLKC

USP16

716

Q9Y5T5
PTLCCLKLAFLDPDT

PHIP

1016

Q8WWQ0
LPAQAAPDLCSLLCL

PIK3R5

856

Q8WYR1
CFACAPPLVVAANID

UBA5

226

Q9GZZ9
CEFSICELALQPPVV

RNF10

571

Q8N5U6
PLAEELSCSICLEPF

TRIM25

6

Q14258
ICSLLTDCNPADPLV

UBE2E3

166

Q969T4
PICLELFEDPLLLPC

MID1

11

O15344
LFEDPLLLPCAHSLC

MID1

16

O15344
AKLECCPNLFSPVLI

SFMBT2

631

Q5VUG0
ICSLLCDPNPDDPLV

UBE2D3

106

P61077
CQPDSVALLDAVPCL

TACC2

1046

O95359
CLLIPCIFSFPADVE

SIGLEC1

36

Q9BZZ2
CPASVLKCAEALQLP

TP53BP1

1926

Q12888
ELSCPLCLQLFDAPV

TRIM72

11

Q6ZMU5
CSLLCNPLSCVPALE

RPAP1

851

Q9BWH6
ASVILNSPPLFCCDL

RALGAPB

561

Q86X10
ELECGTQLCLLFPPD

YTHDC1

481

Q96MU7
CRFGDPECQVILPLL

GART

291

P22102
ARELCINAPAIDPCL

BRF1

171

Q92994
LDCLQTFLPALSCPL

XPOT

681

O43592
LIPDSFVPCVAALCS

TRAPPC8

11

Q9Y2L5
VCLDDENEFPPIILC

WIPI1

421

Q5MNZ9
RLAPCDLSLIPNSAC

WDR27

296

A2RRH5
ICSLLCDPNPDDPLV

UBE2D4

106

Q9Y2X8
SEPSCQRLDFLPLKC

ZFAND2B

11

Q8WV99
PICLELFEDPLLLPC

MID2

31

Q9UJV3
LFEDPLLLPCAHSLC

MID2

36

Q9UJV3
SICSLLTDCNPADPL

UBE2E1

151

P51965
LDLVCKRCFDELSPP

TUT4

951

Q5TAX3
SLPELEDRLQCPICL

TRIM50

6

Q86XT4
CPVCLDFLQEPVSVD

TRIM58

16

Q8NG06
ECDQCKELFPTPALL

ZBTB40

1076

Q9NUA8
ICSLLCDPNPDDPLV

UBE2D1

106

P51668
LLAQPLPDDCEILCG

nan

51

Q8TCH9
DPQNCALPALTLCEK

ZSWIM4

766

Q9H7M6
LAIIFAPCLLRCPDN

MYO9B

1846

Q13459