Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentendoplasmic reticulum quality control compartment

CALR CANX

1.85e-0417252GO:0044322
DomainARHGEF5_35

ARHGEF35 ARHGEF5

2.01e-062272PF15441
DomainARHGEF5/35_N

ARHGEF35 ARHGEF5

2.01e-062272IPR029212
Domain-

CALR CANX

6.03e-0632722.10.250.10
DomainCALRETICULIN_REPEAT

CALR CANX

6.03e-063272PS00805
DomainCalret/calnex

CALR CANX

1.21e-054272IPR001580
DomainCalreticulin

CALR CANX

1.21e-054272PF00262
DomainCALRETICULIN_1

CALR CANX

1.21e-054272PS00803
DomainCALRETICULIN_2

CALR CANX

1.21e-054272PS00804
DomainCalret/calnex_CS

CALR CANX

1.21e-054272IPR018124
DomainCalreticulin/calnexin_P_dom

CALR CANX

2.01e-055272IPR009033
DomainSANT

GON4L ZSCAN20

2.36e-0350272SM00717
DomainSANT/Myb

GON4L ZSCAN20

2.55e-0352272IPR001005
DomainSCAN

ZNF202 ZSCAN20

2.95e-0356272SM00431
DomainSCAN_BOX

ZNF202 ZSCAN20

3.16e-0358272PS50804
DomainSCAN

ZNF202 ZSCAN20

3.16e-0358272PF02023
DomainSCAN_dom

ZNF202 ZSCAN20

3.16e-0358272IPR003309
DomainRetrov_capsid_C

ZNF202 ZSCAN20

3.27e-0359272IPR008916
Domain-

CALR CANX

8.27e-03952722.60.120.200
PathwayREACTOME_CALNEXIN_CALRETICULIN_CYCLE

CALR CANX

4.00e-057202MM15592
PathwayREACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE

CALR CANX

1.99e-0415202MM15175
PathwayBIOCARTA_EIF_PATHWAY

EIF4A2 EIF5

2.27e-0416202M7721
PathwayREACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC

CALR CANX

5.63e-0425202MM15713
PathwayREACTOME_CALNEXIN_CALRETICULIN_CYCLE

CALR CANX

6.09e-0426202M907
PathwayREACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC

CALR CANX

7.59e-0429202M1062
PathwayREACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE

CALR CANX

1.11e-0335202M918
Pubmed

Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum.

CALR CANX

6.25e-07228216467570
Pubmed

Calreticulin is required for development of the cumulus oocyte complex and female fertility.

CALR CANX

6.25e-07228226388295
Pubmed

Compromised calnexin function in calreticulin-deficient cells.

CALR CANX

6.25e-07228212727205
Pubmed

Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control.

CALR CANX

6.25e-07228214731400
Pubmed

Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma.

CALR CANX

6.25e-07228214732231
Pubmed

Calnexin, calreticulin and the folding of glycoproteins.

CALR CANX

6.25e-07228217708944
Pubmed

Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin.

CALR CANX

6.25e-0722828550632
Pubmed

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

BYSL CALR CANX CA2 EIF5

1.81e-0625728531046837
Pubmed

ER-60 domains responsible for interaction with calnexin and calreticulin.

CALR CANX

1.87e-06328215236594
Pubmed

Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin.

CALR CANX

1.87e-0632829312001
Pubmed

Localization of the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin.

CALR CANX

1.87e-06328212052826
Pubmed

The glut 1 glucose transporter interacts with calnexin and calreticulin.

CALR CANX

1.87e-0632828662691
Pubmed

RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy.

CALR CANX

1.87e-06328236224200
Pubmed

Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway.

CALR CANX

1.87e-06328211795871
Pubmed

Molecular chaperones stimulate the functional expression of the cocaine-sensitive serotonin transporter.

CALR CANX

1.87e-06328210364189
Pubmed

Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin.

CALR CANX

1.87e-06328219054761
Pubmed

The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression.

CALR CANX

1.87e-06328211765911
Pubmed

Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum.

CALR CANX

1.87e-06328222242185
Pubmed

Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit.

CALR CANX

3.75e-0642828910335
Pubmed

Cell surface targeting of myelin oligodendrocyte glycoprotein (MOG) in the absence of endoplasmic reticulum molecular chaperones.

CALR CANX

3.75e-06428221172390
Pubmed

Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain.

CALR CANX

3.75e-06428212239218
Pubmed

The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient fibroblasts.

CALR CANX

3.75e-06428214980518
Pubmed

Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin.

CALR CANX

3.75e-06428215677452
Pubmed

Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.

CALR CANX

3.75e-06428212383251
Pubmed

The role of N-glycan in folding, trafficking and pathogenicity of myelin oligodendrocyte glycoprotein (MOG).

CALR CANX

3.75e-06428225541284
Pubmed

A novel quality control compartment derived from the endoplasmic reticulum.

CALR CANX

3.75e-06428211408579
Pubmed

In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein.

CALR CANX

3.75e-06428218791162
Pubmed

Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin.

CALR CANX

3.75e-0642829525969
Pubmed

Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos.

EIF4A2 EIF5

6.24e-0652829746750
Pubmed

Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.

CALR CANX

6.24e-06528220520781
Pubmed

ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin.

CALR CANX

6.24e-06528210436013
Pubmed

The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo.

CALR CANX

9.36e-06628210929008
Pubmed

Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins.

CALR CANX

9.36e-06628219524015
Pubmed

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.

CALR CANX

1.31e-05728211823531
Pubmed

Genes regulating MHC class I processing of antigen.

CALR CANX

1.74e-05828210047538
Pubmed

Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss.

CALR CANX

1.74e-05828230188326
Pubmed

GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.

CALR CANX

2.24e-05928216847323
Pubmed

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.

CALR CANX

2.24e-05928222572157
Pubmed

ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.

CALR CANX

2.80e-05102829545232
Pubmed

Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse.

CALR CANX

3.42e-051128217913437
Pubmed

Getting in and out from calnexin/calreticulin cycles.

CALR CANX

4.85e-051328218303019
Pubmed

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.

CALR CANX

6.52e-051528217090218
Pubmed

The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.

CALR CANX

7.45e-051628219943849
Pubmed

Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.

CALR CANX

8.44e-051728232938586
Pubmed

Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation.

CALR CANX EIF4A2 CA2

1.31e-0432728434428256
Pubmed

Phosphorylated tau interactome in the human Alzheimer's disease brain.

CALR EIF4A2 CA2

1.39e-0412528332812023
Pubmed

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.

BYSL AAMP CALR CWC27 EIF5

2.24e-0470428532994395
Pubmed

Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

CALR CANX CA2 EIF5

2.26e-0437728425147182
Pubmed

Next-generation sequencing to generate interactome datasets.

BYSL AAMP UBXN11 ZBED1 ARHGEF5 EIF4A2

2.57e-04114728621516116
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

BSDC1 NDC80 CALR CANX EIF4A2 CA2

2.66e-04115528620360068
Pubmed

A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea.

CALR EIF4A2 CA2

2.72e-0415728319423573
Pubmed

Purification and identification of G protein-coupled receptor protein complexes under native conditions.

CALR CANX

2.86e-043128217215244
Pubmed

Hepatic lipase maturation: a partial proteome of interacting factors.

CALR CANX

2.86e-043128219136429
Pubmed

The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

CALR CANX

2.86e-043128222013210
Pubmed

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

AAMP ARHGEF35 CLEC11A EIF5

3.38e-0441928428700943
Pubmed

Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.

EIF4A2 CA2

4.09e-043728219034380
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

MAGI2 ZNF202 SPOCK2 TARS3 TRIM52 EIF4A2

4.71e-04128528635914814
Pubmed

Agrin has a pathological role in the progression of oral cancer.

CANX EIF4A2 EIF5

5.28e-0419728329872149
Pubmed

Network-based prediction of protein interactions.

BYSL NDC80

5.79e-044428230886144
Pubmed

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

CALR CANX

6.06e-04452821286667
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

BYSL AAMP CALR CANX EIF5

6.15e-0487828537223481
Pubmed

Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells.

CALR CANX

6.33e-044628227751915
Pubmed

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

CALR CANX CA2 EIF5

6.33e-0449528428581483
Pubmed

The in vivo brain interactome of the amyloid precursor protein.

CALR CANX

7.48e-045028217934213
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

BYSL AAMP ZBED1

7.57e-0422328333187986
Pubmed

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

CALR EIF4A2 EIF5

7.77e-0422528325277244
Cytoband7q35

ARHGEF35 ARHGEF5

5.22e-04552827q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

ARHGEF35 ARHGEF5

7.51e-0466282chr7q35
CytobandEnsembl 112 genes in cytogenetic band chr1p35

BSDC1 ZSCAN20

3.18e-03137282chr1p35
CytobandEnsembl 112 genes in cytogenetic band chr5q35

TRIM52 CANX

9.03e-03235282chr5q35
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GON4L ZSCAN20

1.55e-0353202532
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF35 ARHGEF5

2.39e-0366202722
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

SPOCK2 TARS3 TRIM52

1.14e-04151283999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCellBAL-Mild-Myeloid-TRAM-TRAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UBXN11 PLEKHA6 WDR97

1.14e-0415128328e3f77d2edb30fcf1414762a55ceffaf879d526
ToppCellBAL-Mild-Myeloid-TRAM-TRAM2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UBXN11 PLEKHA6 WDR97

1.14e-04151283688cc5e4d46ba16f9b431352d7a6d39b21941e9c
ToppCellBAL-Mild-Myeloid-TRAM-TRAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

UBXN11 PLEKHA6 WDR97

1.14e-0415128345392bb1c6358beff33da0ca84f7696fb5824f30
ToppCellBAL-Mild-Myeloid-TRAM-TRAM2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

UBXN11 PLEKHA6 WDR97

1.14e-041512833d861285c71abe220b19a069eb9876199c6c8f39
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPOCK2 TARS3 ZSCAN20

1.21e-04154283ec920cae12ea1d14b6c973f6e903f895f80e3c50
ToppCellMild_COVID-19-Myeloid-TRAM2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

UBXN11 PLEKHA6 WDR97

1.21e-04154283ab648f6b29eb9e499e46cbdbaf3c5cf6b94d1f64
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI2 ATP11A CWC27

1.31e-04158283d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI2 ATP11A CWC27

1.31e-04158283df614450e10629dc9115d7365397663e82f9e48f
ToppCellMild-MAIT|World / Disease group and Cell class

SPOCK2 ELL3 CA2

1.46e-0416428321dc02997dfae73cf70ce291661928526605dba1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

1.82e-04177283da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI2 SPOCK2 CLEC11A

1.95e-04181283ebf1ae963a2b22e1772752ed85a4fb0e546d377e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.01e-041832833c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.01e-04183283848fc6dd129150897ee339343e83c645b6e779eb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.01e-041832839c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

GON4L CLEC11A TRIM52

2.04e-04184283ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.04e-041842837294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D3|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

MAML3 EIF4A2 EIF5

2.08e-041852834a5e70ac41e5f3b25a773304ffef3c2a3dd5549d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.08e-0418528334fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.08e-041852838816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-CMP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.11e-04186283895905f1d1a01ffd5617a0baa8818693a7e9cb3b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.18e-04188283874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 SPOCK2 MAML3

2.18e-04188283b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPOCK2 ARHGEF35 ARHGEF5

2.25e-04190283b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPOCK2 ARHGEF35 ARHGEF5

2.25e-04190283a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCelltumor_Lung-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

ARHGEF35 ARHGEF5 CA2

2.25e-0419028358a6ab70737d719ca9725ac087f20dfe9be0463e
ToppCellT_cells-Effector_memory_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SPOCK2 TARS3 CA2

2.25e-041902831af91fe0ee2c924e12f4db93c793e7af475d8f80
ToppCelldroplet-Pancreas-Endocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALR CANX EIF4A2

2.32e-041922834510aa262da8dcf7c944b3907a51aba5a9397a4e
ToppCell10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-GMP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.39e-0419428302b7911d07938f04f369a552dedc614930e4396e
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-CD8_Naive|Multiple_Sclerosis / Disease, Lineage and Cell Type

SPOCK2 CLEC11A EIF4A2

2.39e-0419428342a9a170022f07445a7ee2577707924bbc0269db
ToppCellmyeloid-CD34+_Myeloblast|World / Lineage and Cell class

CALR CLEC11A CANX

2.39e-04194283426d5cf04e21fec2fb6ea51abd85441b2dc5c94f
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BYSL CWC27 MAML3

2.39e-041942830e9830ad070c47acaa952400bf2a3ddbff664a2f
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-neutrophil-promyelocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.46e-041962838ff0135e108764a3527acc00a994ced342e1cad1
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-GMP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.46e-041962833cf73b33330b9fca5c8abf03f2f0d8244245b522
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPOCK2 CALR EIF4A2

2.46e-04196283a9157809122e6fc5783a291522f103bef30943e4
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-GMP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.50e-04197283462e91dc51e363d64e1e02d7444a733838e032a5
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-neutrophil-promyelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.50e-041972836fe4a9f67291a7e4260984e901d069ff1746d0be
ToppCell10x5'v1-week_14-16-Myeloid_monocytic-monocyte-MOP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.50e-041972834e68a98bc7e5db7f20e865a0ca21e5a43b3cbb8f
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil-promyelocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.50e-04197283cfc9decbfa9ebadafda8b620ec529d3fcdd15dcd
ToppCell10x3'2.3-week_14-16-Myeloid_monocytic-monocyte-MOP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.50e-04197283cbfe62cd4c38ae3c893b869e8af8defb9777df25
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-Treg|ICU-SEP / Disease, condition lineage and cell class

SPOCK2 ARHGEF35 ARHGEF5

2.50e-04197283c3ee2d522fbfe67069ddba2d1abfc4f5ca230c26
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

MAGI2 ATP11A MAML3

2.54e-041982831996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellmild|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SPOCK2 CALR EIF4A2

2.54e-041982833cef2e13d5ec71bb265171239980697a2560fa30
ToppCell10x3'2.3-week_17-19-Myeloid_monocytic-monocyte-MOP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.54e-04198283f333f9ba4ac4c2c4e59dce304db20bdb8626bf07
ToppCell10x3'2.3-week_12-13-Myeloid_monocytic-monocyte-MOP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.54e-041982833a923a2ac932fd7125f9f0836d1f06a513dc3b70
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CALR EIF4A2 EIF5

2.54e-04198283a1c8e5c332336823c47c04e56b6d7bc8f057c9da
ToppCell368C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CALR CLEC11A CANX

2.57e-041992838766796041965a1ba40ad7abdbc244bf1418c209
ToppCell368C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CALR CLEC11A CANX

2.57e-04199283d39b40d84c72bdde756b805063317ecfad3784f8
ToppCellcontrol-CD8+_T_naive|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SPOCK2 CLEC11A EIF4A2

2.57e-041992836a61ce7404c65e506091fee99a2001f5a9b39f31
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-GMP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CALR CLEC11A CANX

2.57e-04199283030fa11c788f961cd7b21eea091c409efbf9bf24
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-CD8+_T_naive|Multiple_Sclerosis / Disease, condition lineage and cell class

SPOCK2 CLEC11A EIF4A2

2.61e-042002833c919578aed30f77408a3405bce7b71bcda203e0
ToppCellmetastatic_Lymph_Node-Epithelial_cells-Malignant_cells|Epithelial_cells / Location, Cell class and cell subclass

ATP11A CALR CANX

2.61e-04200283b16da9c342f9ff5ed4983c65b7d3b59123a594cd
DrugDoxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A

BSDC1 GON4L ATP11A PLEKHA6 CALR

3.76e-061962854819_DN
DrugeV F

NDC80 CA2

1.46e-055282CID000067944
Drugdihydroxyaluminum aminoacetate

CALR CANX

2.18e-056282ctd:C007420
Drugzinc selenide (ZnSe

CALR CA2

3.05e-057282CID000073979
DrugAC1L1CUL

CALR CANX

6.52e-0510282CID000002070
DrugTenecteplase

CALR CANX

7.97e-0511282DB00031
DrugAntihemophilic Factor

CALR CANX

7.97e-0511282DB00025
DrugBetazole hydrochloride; Down 200; 27uM; HL60; HT_HG-U133A

BYSL CALR CLEC11A CA2

9.28e-051962841854_DN
DrugCyclopentolate hydrochloride [5870-29-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A

ZNF202 ATP11A CALR CLEC11A

9.65e-051982843555_DN
DrugPergolide mesylate [66104-23-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A

GON4L PLEKHA6 CLEC11A TRIM52

1.00e-042002847031_UP
DrugEMATE

NDC80 CA2

1.73e-0416282CID000127676
Drugcyanyl

CANX CA2

2.73e-0420282CID005359238
Drugcyanogen

CANX CA2

3.32e-0422282CID000009999
DrugN-nonyl-deoxygalactonojirimycin

CALR CANX

3.63e-0423282CID000501390
DrugAC1L1KC5

SPOCK2 UBXN11 CALR CANX CA2

4.65e-04541285CID000005428
DrugAC1L970Z

CALR CANX

5.80e-0429282CID000439275
DrugSialic acids

NDC80 CALR CLEC11A CANX

6.66e-04329284CID000349960
DrugSureCN1562346

NDC80 CANX

7.52e-0433282CID011646228
DiseaseOsteoporosis, Senile

CLEC11A CA2

1.13e-0361242C0029459
DiseaseOsteoporosis, Age-Related

CLEC11A CA2

1.13e-0361242C0001787
DiseasePost-Traumatic Osteoporosis

CLEC11A CA2

1.13e-0361242C0751406
DiseaseOsteoporosis

CLEC11A CA2

1.20e-0363242C0029456
DiseaseSquamous cell carcinoma of esophagus

CALR CA2

2.70e-0395242C0279626
DiseaseAdenoid Cystic Carcinoma

MAGI2 MAML3

2.99e-03100242C0010606
Diseasecannabis dependence

MAGI2 MAML3

5.37e-03135242EFO_0007191
Diseasesevere acute respiratory syndrome, COVID-19

MAGI2 ATP11A CWC27

5.52e-03447243EFO_0000694, MONDO_0100096
Diseasestomach cancer (is_marker_for)

NDC80 CALR

5.92e-03142242DOID:10534 (is_marker_for)
Diseasecolorectal cancer (is_marker_for)

NDC80 CALR

7.19e-03157242DOID:9256 (is_marker_for)
DiseasePR interval

MAGI2 UBXN11 NDC80

7.31e-03495243EFO_0004462
Diseaselung non-small cell carcinoma (is_marker_for)

NDC80 CALR

8.29e-03169242DOID:3908 (is_marker_for)
DiseaseMyocardial Ischemia

CALR CANX

8.96e-03176242C0151744

Protein segments in the cluster

PeptideGeneStartEntry
WNHMDEEPDNGDDRG

AGPAT4-IT1

46

Q9H0P7
EGEDWEQEDEDMDPR

ELL3

251

Q9HB65
NDIPETEVEDDEGWM

CWC27

406

Q6UX04
SEEPGWEEEEEELMG

BSDC1

216

Q9NW68
EEEEGNEEGWVLEPQ

AAMP

56

Q13685
EPEGLNDGEWEQEDM

ARHGEF5

296

Q12774
EPEGLNDGEWEQEDM

ARHGEF35

296

A5YM69
EDNEEPDPLPDNWEM

MAGI2

296

Q86UL8
GGPGDEWMQELDELF

MAML3

1121

Q96JK9
PPHTMEEEEDDDWGE

EIF5

191

P55010
WLGGLMNDDVGNEDE

GON4L

536

Q3T8J9
EDWDEEMDGEWEPPV

CALR

251

P27797
DWDEDMDGEWEAPQI

CANX

341

P27824
EGMDPDGVIESNWNE

EIF4A2

16

Q14240
PRMPQDGSDDEDEEW

BYSL

91

Q13895
PENFLGEIEMWNEAE

TARS3

581

A2RTX5
NGEGEPEELMVDNWR

CA2

231

P00918
EGKEDWEMEEDQGEE

CLEC11A

71

Q9Y240
WDEDMFDEETGEGPL

ATP11A

381

P98196
EEDEEAVGAMDGWDG

TRIM52

66

Q96A61
ESPEEQEAWIQAMGE

PLEKHA6

141

Q9Y2H5
EMDEQEEGGWDPEEM

ZSCAN20

436

P17040
EEGGWDPEEMAEDCN

ZSCAN20

441

P17040
LQWMGEKPGEEGEED

WDR97

1086

A6NE52
EAEPEDQDEGEWGLD

ZBED1

656

O96006
EPEDQDLWEEEGILM

ZNF202

6

O95125
EGETPGNFMEDEQWL

SPOCK2

31

Q92563
GLQWVGEPMDQEDSE

UBXN11

151

Q5T124
DDGQPWGEETEDGIM

NDC80

206

O14777