Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase binding	CCNT1 CCNT2 SCAF1 PCIF1	1.22e-04	65	78	4	GO:0070063
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	RYBP JARID2 CCNT1 ZSWIM8 SUPT3H PPRC1 SUB1 FGA TMF1 ICE1 ZC3H18 ARID1A SPEN THRAP3	1.43e-04	1160	78	14	GO:0030674
GeneOntologyMolecularFunction	7SK snRNA binding	CCNT1 CCNT2	5.33e-04	9	78	2	GO:0097322
GeneOntologyMolecularFunction	molecular adaptor activity	RYBP JARID2 CCNT1 ZSWIM8 SUPT3H PPRC1 SUB1 FGA TMF1 ICE1 ZC3H18 ARID1A SPEN THRAP3	7.01e-04	1356	78	14	GO:0060090
GeneOntologyMolecularFunction	RNA polymerase II C-terminal domain binding	SCAF1 PCIF1	8.10e-04	11	78	2	GO:0099122
GeneOntologyBiologicalProcess	mRNA processing	ARL6IP4 SCAF1 RNPS1 CDK13 SRSF8 ZRANB2 PCIF1 SRRM2 THRAP3 RSRC1 CLASRP NCBP3	1.02e-06	551	78	12	GO:0006397
GeneOntologyBiologicalProcess	RNA splicing	ARL6IP4 SCAF1 SUPT3H RNPS1 CDK13 SRSF8 ZRANB2 SRRM2 THRAP3 RSRC1 CLASRP	2.84e-06	502	78	11	GO:0008380
GeneOntologyBiologicalProcess	mRNA metabolic process	ARL6IP4 SCAF1 RNPS1 CDK13 SRSF8 ZRANB2 PCIF1 EDC4 SRRM2 ZBTB1 THRAP3 RSRC1 CLASRP NCBP3	7.69e-06	917	78	14	GO:0016071
GeneOntologyCellularComponent	nuclear speck	ARL6IP4 CACNB4 RNPS1 CDK13 SRSF8 ZC3H18 TOPORS SRRM2 THRAP3 RSRC1 NCBP3	4.96e-07	431	77	11	GO:0016607
GeneOntologyCellularComponent	transcription elongation factor complex	CCNT1 CCNT2 CDK13 ICE1 SSRP1	1.96e-06	56	77	5	GO:0008023
GeneOntologyCellularComponent	cyclin/CDK positive transcription elongation factor complex	CCNT1 CCNT2 CDK13	3.97e-06	9	77	3	GO:0008024
GeneOntologyCellularComponent	nuclear body	ARL6IP4 CACNB4 RNPS1 CDK13 SRSF8 ICE1 ZC3H18 TOPORS SRRM2 ZBTB1 THRAP3 RSRC1 NCBP3	2.37e-05	903	77	13	GO:0016604
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	CCNT1 CCNT2 CDK13	3.77e-05	18	77	3	GO:0019908
GeneOntologyCellularComponent	carboxy-terminal domain protein kinase complex	CCNT1 CCNT2 CDK13	9.20e-05	24	77	3	GO:0032806
GeneOntologyCellularComponent	nuclear protein-containing complex	RYBP JARID2 CCNT1 CCNT2 SUPT3H ZC3H11A RNPS1 CDK13 ICE1 SSRP1 ARID1A SRRM2 THRAP3	1.46e-03	1377	77	13	GO:0140513
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CCNT1 CCNT2 CDK13	1.48e-03	61	77	3	GO:0000307
Domain	Cyclin_L/T	CCNT1 CCNT2	4.27e-04	8	74	2	IPR015429
Domain	JmjN	JARID2 KDM4A	6.83e-04	10	74	2	SM00545
Domain	JMJN	JARID2 KDM4A	6.83e-04	10	74	2	PS51183
Domain	JmjN	JARID2 KDM4A	6.83e-04	10	74	2	PF02375
Domain	JmjN	JARID2 KDM4A	6.83e-04	10	74	2	IPR003349
Domain	TIL	MUC19 MUC6	9.96e-04	12	74	2	PF01826
Domain	C8	MUC19 MUC6	9.96e-04	12	74	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC19 MUC6	1.17e-03	13	74	2	IPR014853
Domain	C8	MUC19 MUC6	1.17e-03	13	74	2	SM00832
Domain	TIL_dom	MUC19 MUC6	1.37e-03	14	74	2	IPR002919
Domain	-	JARID2 ARID1A	1.57e-03	15	74	2	1.10.150.60
Domain	BRIGHT	JARID2 ARID1A	1.57e-03	15	74	2	SM00501
Domain	ARID_dom	JARID2 ARID1A	1.57e-03	15	74	2	IPR001606
Domain	ARID	JARID2 ARID1A	1.57e-03	15	74	2	PS51011
Domain	ARID	JARID2 ARID1A	1.57e-03	15	74	2	PF01388
Domain	VWD	MUC19 MUC6	1.79e-03	16	74	2	SM00216
Domain	VWF_type-D	MUC19 MUC6	1.79e-03	16	74	2	IPR001846
Domain	VWFD	MUC19 MUC6	1.79e-03	16	74	2	PS51233
Domain	VWD	MUC19 MUC6	1.79e-03	16	74	2	PF00094
Domain	VWC_out	MUC19 MUC6	2.54e-03	19	74	2	SM00215
Domain	-	RNPS1 PPRC1 SRSF8 SPEN NCBP3	2.83e-03	244	74	5	3.30.70.330
Domain	zf-RanBP	RYBP ZRANB2	3.40e-03	22	74	2	PF00641
Domain	CT	MUC19 MUC6	3.40e-03	22	74	2	SM00041
Domain	Nucleotide-bd_a/b_plait	RNPS1 PPRC1 SRSF8 SPEN NCBP3	3.59e-03	258	74	5	IPR012677
Domain	ZnF_RBZ	RYBP ZRANB2	3.71e-03	23	74	2	SM00547
Domain	ZF_RANBP2_2	RYBP ZRANB2	3.71e-03	23	74	2	PS50199
Domain	JmjC	JARID2 KDM4A	4.04e-03	24	74	2	PF02373
Domain	ZF_RANBP2_1	RYBP ZRANB2	4.04e-03	24	74	2	PS01358
Domain	Znf_RanBP2	RYBP ZRANB2	4.38e-03	25	74	2	IPR001876
Domain	Cys_knot_C	MUC19 MUC6	4.38e-03	25	74	2	IPR006207
Domain	CTCK_2	MUC19 MUC6	4.38e-03	25	74	2	PS01225
Domain	CYCLINS	CCNT1 CCNT2	5.48e-03	28	74	2	PS00292
Domain	JMJC	JARID2 KDM4A	7.11e-03	32	74	2	PS51184
Domain	JmjC_dom	JARID2 KDM4A	7.11e-03	32	74	2	IPR003347
Domain	JmjC	JARID2 KDM4A	7.55e-03	33	74	2	SM00558
Domain	Cyclin_N	CCNT1 CCNT2	7.55e-03	33	74	2	IPR006671
Domain	Cyclin_N	CCNT1 CCNT2	7.55e-03	33	74	2	PF00134
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	CCNT1 CCNT2 CDK13 SSRP1	2.61e-05	47	52	4	MM15328
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC19 MUC16 MUC6	6.01e-05	21	52	3	MM15706
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	CCNT1 CCNT2 CDK13 SSRP1	7.84e-05	62	52	4	M27618
Pathway	KEGG_MEDICUS_VARIANT_MLL_AF4_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION	CCNT1 CCNT2 SUPT3H	1.16e-04	26	52	3	M47439
Pathway	REACTOME_HIV_ELONGATION_ARREST_AND_RECOVERY	CCNT1 CCNT2 SSRP1	2.39e-04	33	52	3	M27010
Pubmed	The protein interaction landscape of the human CMGC kinase group.	ARL6IP4 CCNT1 CCNT2 FRY CHERP HIRIP3 RNPS1 SUB1 CDK13 SRSF8 ZRANB2 ICE1 LZTS2 SRRM2 THRAP3 RSRC1 CLASRP NCBP3	1.45e-14	695	78	18	23602568
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ARL6IP4 RYBP SCAF1 SUPT3H ZC3H11A CHERP HIRIP3 RNPS1 SUB1 CDK13 SRSF8 FNBP4 CIZ1 ZC3H18 NKTR SSRP1 ARID1A SRRM2 SPEN THRAP3 RSRC1 CLASRP	5.81e-14	1294	78	22	30804502
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CCNT2 SCAF1 ZC3H11A HIRIP3 RNPS1 SUB1 CDK13 ZRANB2 FNBP4 ZC3H18 SSRP1 TOPORS SRRM2 SPEN THRAP3 CLASRP	1.48e-11	774	78	16	15302935
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ARL6IP4 CCNT1 CCNT2 ZC3H11A CHERP RNPS1 SRSF8 ZRANB2 ZC3H18 NKTR SRRM2 THRAP3 RSRC1 CLASRP NCBP3	5.43e-11	713	78	15	29802200
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	ARL6IP4 SCAF1 HIRIP3 SUB1 SRSF8 ZRANB2 ZC3H18 SSRP1 SPEN THRAP3	2.62e-10	251	78	10	31076518
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ARL6IP4 ZC3H11A CHERP RNPS1 SUB1 CDK13 SRSF8 ZRANB2 ZC3H18 SSRP1 SRRM2 SPEN MEX3B THRAP3 NCBP3	3.01e-10	807	78	15	22681889
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	ARL6IP4 SCAF1 CHERP RNPS1 CDK13 ZRANB2 NKTR SSRP1 SRRM2 THRAP3	3.56e-10	259	78	10	30404004
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	ARL6IP4 CCNT1 RNPS1 SUB1 CDK13 ZRANB2 ZC3H18 EDC4 ARID1A SRRM2 SPEN THRAP3 RSRC1	2.87e-09	665	78	13	30457570
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ARL6IP4 CCNT1 SCAF1 ZSWIM8 SUPT3H RNPS1 ASH1L CIZ1 CLMP ZC3H18 LZTS2 SSRP1 ARID1A TOPORS SRRM2 BRWD1	3.02e-09	1116	78	16	31753913
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	ARL6IP4 HIRIP3 SUB1 ZRANB2 FNBP4 SSRP1 SRRM2 THRAP3	3.48e-09	163	78	8	22113938
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ZC3H11A SUB1 DVL1 FNBP4 CIZ1 SPECC1L EDC4 LZTS2 SSRP1 ARID1A SPEN THRAP3	3.58e-09	549	78	12	38280479
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	ZNF703 ZSWIM8 CHERP MTMR3 TMF1 ZC3HC1 SSRP1 ZBTB1	4.21e-09	167	78	8	25659891
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	RYBP JARID2 ZC3H11A CDK13 ZRANB2 ZC3H18 SSRP1 ARID1A SPEN CLASRP NCBP3	8.24e-09	469	78	11	27634302
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	ARL6IP4 ZC3H11A RNPS1 SUB1 SRSF8 ZRANB2 FNBP4 ZC3H18 SSRP1 SRRM2 SPEN THRAP3 RSRC1	8.84e-09	731	78	13	29298432
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	RNPS1 ZRANB2 ZC3H18 NKTR SSRP1 SRRM2 THRAP3 NCBP3	1.07e-08	188	78	8	29721183
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	CCNT1 CCNT2 ZNF703 TMPRSS13 CDK13 SRRM2 THRAP3 CLASRP	1.53e-08	197	78	8	20811636
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CCNT1 ZC3H11A CHERP SUB1 FNBP4 CIZ1 ICE1 ZC3H18 SSRP1 ARID1A SRRM2 SPEN THRAP3 NCBP3	2.49e-08	954	78	14	36373674
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	JARID2 CCNT1 SCAF1 SUPT3H ZC3H11A CDK13 ZRANB2 CIZ1 TMF1 FAM83D ICE1 SPECC1L EDC4 LZTS2 SSRP1 SPEN RSRC1	2.83e-08	1497	78	17	31527615
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	CCNT1 HIRIP3 RNPS1 SUB1 CIZ1 KDM4A ZC3H18 SSRP1 SPEN NCBP3 BRWD1	1.15e-07	608	78	11	36089195
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC19 MUC16 MUC6	2.16e-07	6	78	3	19110483
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	CCNT1 ZC3H11A SUB1 ZRANB2 ZC3H18 SSRP1 SPEN THRAP3	2.49e-07	283	78	8	30585729
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	CCNT1 ZC3H11A CHERP RNPS1 ZRANB2 FNBP4 ZC3H18 SPECC1L SSRP1 SRRM2 THRAP3 RSRC1	4.01e-07	847	78	12	35850772
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	USP31 SUB1 CDK13 SYT17 MTMR3 MUC16 SSRP1 SRRM2 SPEN	4.38e-07	420	78	9	28065597
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ARL6IP4 ZSWIM8 HIRIP3 RNPS1 GYS1 DVL1 POC5 EDC4 LZTS2 SSRP1 ZBTB1 THRAP3 CLASRP	5.07e-07	1038	78	13	26673895
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	RYBP GPR161 CCNT1 CCNT2 ZSWIM8 HIRIP3 FAM83D ZC3H18 THRAP3	5.54e-07	432	78	9	23455922
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	ARL6IP4 SCAF1 RNPS1 SRSF8 ZC3H18 NKTR SSRP1 THRAP3	7.95e-07	330	78	8	33301849
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CCNT2 CHERP SUB1 GYS1 ZRANB2 FNBP4 ZC3H18 SSRP1 ARID1A SRRM2 SPEN THRAP3 PRPH	8.07e-07	1082	78	13	38697112
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	CCNT1 ZNF703 SUPT3H ZC3H11A RNPS1 MUC19 SSRP1 SPEN	9.72e-07	339	78	8	30415952
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ARL6IP4 CCNT1 CCNT2 ZC3H11A SUB1 CDK13 ZRANB2 EDC4 SSRP1 ARID1A SRRM2 SPEN THRAP3	9.99e-07	1103	78	13	34189442
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	CCNT1 ZC3H18 EDC4 ARID1A SRRM2 SPEN THRAP3 NCBP3	1.02e-06	341	78	8	32971831
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	RYBP JARID2 ASH1L KDM4A SSRP1 ARID1A	1.51e-06	157	78	6	30186101
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SCAF1 CDK13 ICE1 ZC3H18 SRRM2 SPEN THRAP3 CLASRP	1.55e-06	361	78	8	26167880
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ARL6IP4 TCEA3 SCAF1 RNPS1 CDK13 SRSF8 FNBP4 NKTR SPECC1L LZTS2 SSRP1 THRAP3 RSRC1 NCBP3	1.98e-06	1371	78	14	36244648
Pubmed	CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.	CCNT2 RNPS1 ZRANB2 SSRP1 THRAP3	2.34e-06	94	78	5	37468549
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SCAF1 ZC3H11A CHERP RNPS1 CIZ1 SPECC1L EDC4 SSRP1 SRRM2 SPEN THRAP3 NCBP3	2.89e-06	1024	78	12	24711643
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ARL6IP4 CCNT1 CCNT2 RNPS1 DVL1 FAM83D SPECC1L LZTS2 SSRP1 ARID1A TOPORS SRRM2 THRAP3	3.85e-06	1247	78	13	27684187
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	CCNT1 CCNT2 CDK13 ARID1A SRRM2 STAG3	4.03e-06	186	78	6	33637726
Pubmed	NCBP3 positively impacts mRNA biogenesis.	ZC3H18 NCBP3	4.97e-06	2	78	2	32960271
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SCAF1 ZC3H11A PPRC1 CDK13 TMCC2 DVL1 MTMR3 ICE1 EDC4 ARID1A SPEN TIAM2	6.28e-06	1105	78	12	35748872
Pubmed	Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.	SUB1 SRSF8 PCIF1 SSRP1 THRAP3	6.58e-06	116	78	5	37117180
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CCNT1 ZSWIM8 CHERP RNPS1 ZC3H18 SPEN THRAP3	6.84e-06	313	78	7	38270169
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	ARL6IP4 CCNT1 SCAF1 CHERP RNPS1 SUB1 SRSF8 GYS1 NKTR SSRP1 SRRM2 THRAP3 RSRC1	6.99e-06	1318	78	13	30463901
Pubmed	Regulation of alternative splicing by SRrp86 and its interacting proteins.	SRSF8 ZRANB2 SSRP1 THRAP3	8.45e-06	57	78	4	14559993
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	CHERP FNBP4 ZC3H18 SSRP1 ARID1A SRRM2 SPEN THRAP3 NCBP3	8.62e-06	605	78	9	28977666
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC19 MUC16 MUC6	8.64e-06	18	78	3	18834073
Pubmed	Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.	JARID2 ICE1 THRAP3	8.64e-06	18	78	3	20064376
Pubmed	Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.	RYBP SUPT3H OLFM4 POC5 RSRC1	1.10e-05	129	78	5	23563607
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	ZC3H11A CHERP SUB1 SRRM2 THRAP3	1.15e-05	130	78	5	35545047
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	ARPP21 CDK13 POC5 SRRM2 THRAP3	1.28e-05	133	78	5	15144186
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	ARL6IP4 ZNF703 HIRIP3 RNPS1 CIZ1 ZC3HC1 EDC4 SPEN THRAP3	1.43e-05	645	78	9	25281560
Pubmed	Regulation of P-TEFb elongation complex activity by CDK9 acetylation.	CCNT1 CCNT2	1.49e-05	3	78	2	17452463
Pubmed	Cyclin T2 is essential for mouse embryogenesis.	CCNT1 CCNT2	1.49e-05	3	78	2	19364821
Pubmed	Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.	CCNT1 CCNT2	1.49e-05	3	78	2	10329126
Pubmed	Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.	CCNT1 CCNT2	1.49e-05	3	78	2	10364329
Pubmed	Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading.	CIZ1 SPEN	1.49e-05	3	78	2	34112668
Pubmed	Identification of multiple cyclin subunits of human P-TEFb.	CCNT1 CCNT2	1.49e-05	3	78	2	9499409
Pubmed	Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.	CCNT1 CCNT2	1.49e-05	3	78	2	10049833
Pubmed	The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity.	CCNT1 CCNT2	1.49e-05	3	78	2	10465067
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	ARL6IP4 ZNF703 CHERP RNPS1 CDK13 ZRANB2 ZC3H18 SRRM2 THRAP3	1.62e-05	655	78	9	35819319
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ZC3H11A HIRIP3 CDK13 TMF1 ZC3HC1 SRRM2 SPEN THRAP3	1.75e-05	503	78	8	16964243
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	CCNT1 CHERP CDK13 ZRANB2 FNBP4 ARID1A SRRM2 THRAP3	1.83e-05	506	78	8	30890647
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	CCNT1 CCNT2 ZC3H11A ZC3H18 THRAP3	2.14e-05	148	78	5	32538781
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	CHERP RNPS1 ARID1A SRRM2 THRAP3	2.59e-05	154	78	5	16055720
Pubmed	The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions.	CCNT1 CCNT2	2.97e-05	4	78	2	11282025
Pubmed	The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.	CCNT1 CCNT2	2.97e-05	4	78	2	18566585
Pubmed	Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb.	CCNT1 CCNT2	2.97e-05	4	78	2	15563843
Pubmed	IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty.	IGSF10 PRPH	2.97e-05	4	78	2	27137492
Pubmed	Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription.	CCNT1 CCNT2	2.97e-05	4	78	2	17289077
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	ZC3H11A RNPS1 SRRM2 THRAP3 NCBP3	3.31e-05	162	78	5	31363146
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	CCNT1 RNPS1 CDK13 SRSF8 FAM83D SPEN NCBP3	3.87e-05	410	78	7	26949251
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	ASH1L SSRP1 THRAP3	4.22e-05	30	78	3	17403666
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	SCAF1 RNPS1 SUB1 PPP1R14D ARID1A SPEN	4.33e-05	283	78	6	18854154
Pubmed	Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.	CCNT1 CDK13	4.94e-05	5	78	2	22547058
Pubmed	Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.	CCNT1 CCNT2	4.94e-05	5	78	2	19883659
Pubmed	The RNA polymerase II elongation complex.	CCNT1 CCNT2 SSRP1	5.64e-05	33	78	3	12676794
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ZC3H11A HIRIP3 ZRANB2 TMF1 MUC16 ZC3HC1 SPECC1L SPEN THRAP3	6.10e-05	777	78	9	35844135
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	SCAF1 ZSWIM8 RNPS1 SYT17 TMF1 LZTS2 SPEN CLASRP	6.67e-05	608	78	8	16713569
Pubmed	Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13.	CCNT1 CDK13	7.40e-05	6	78	2	31440507
Pubmed	Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.	CCNT1 CCNT2	7.40e-05	6	78	2	24515107
Pubmed	7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes.	CCNT1 CCNT2	7.40e-05	6	78	2	11713533
Pubmed	AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.	CCNT1 CCNT2	7.40e-05	6	78	2	17938200
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	CCNT1 EDC4 SSRP1 ARID1A SPEN	7.97e-05	195	78	5	19454010
Pubmed	TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.	ARL6IP4 TCEA3 SSRP1 SRRM2 THRAP3 BRWD1	8.10e-05	317	78	6	30997501
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FNBP4 ICE1 SPEN ZBTB1	8.42e-05	102	78	4	10231032
Pubmed	Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.	ARL6IP4 SUB1 SRSF8 SRRM2 RSRC1	1.03e-04	206	78	5	34185411
Pubmed	MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.	CCNT1 CCNT2	1.04e-04	7	78	2	12832472
Pubmed	Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.	CCNT1 CCNT2	1.04e-04	7	78	2	15201869
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZSWIM8 ZC3H11A CHERP ZC3H18 EDC4 ARID1A SRRM2 SPEN	1.09e-04	653	78	8	22586326
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	CHERP RNPS1 ZC3H18 SRRM2	1.34e-04	115	78	4	17332742
Pubmed	Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.	SSRP1 ARID1A	1.38e-04	8	78	2	20599239
Pubmed	TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation.	RNPS1 THRAP3	1.38e-04	8	78	2	20123736
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	CHERP FGA FAM83D ZC3H18 SPECC1L LZTS2 THRAP3	1.38e-04	503	78	7	36217030
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	ZNF703 ASH1L MUC19 ARID1A	1.74e-04	123	78	4	26912792
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	CACNB4 FGA SRRM2 THRAP3 BRWD1	1.76e-04	231	78	5	16452087
Pubmed	Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.	RGCC STAG3	1.77e-04	9	78	2	20635389
Pubmed	The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.	SUB1 SSRP1	1.77e-04	9	78	2	30508113
Pubmed	TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.	CCNT1 CCNT2	1.77e-04	9	78	2	18391197
Pubmed	Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.	RGCC STAG3	1.77e-04	9	78	2	19270026
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	ARL6IP4 ZC3H11A ZRANB2 FNBP4 NKTR SPECC1L RSRC1 CLASRP	1.77e-04	701	78	8	30196744
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CCNT1 CCNT2 ASH1L ZC3H18 SSRP1 ARID1A SRRM2	1.97e-04	533	78	7	30554943
Interaction	SNIP1 interactions	ARL6IP4 CCNT1 SCAF1 CHERP RNPS1 CDK13 SRSF8 GYS1 ZRANB2 ZC3H18 NKTR SSRP1 ARID1A TOPORS SRRM2 THRAP3 CLASRP NCBP3	1.80e-14	417	77	18	int:SNIP1
Interaction	PIP4K2A interactions	ARL6IP4 CCNT1 RNPS1 PPRC1 SRSF8 ZRANB2 EDC4 LZTS2 SRRM2 SPEN MEX3B CLASRP	3.37e-11	216	77	12	int:PIP4K2A
Interaction	SRSF6 interactions	SCAF1 ZC3H11A CHERP RNPS1 SUB1 CDK13 SRSF8 ZC3H18 NKTR SSRP1 TOPORS SRRM2 SPEN THRAP3 CLASRP NCBP3	6.03e-11	503	77	16	int:SRSF6
Interaction	DHX8 interactions	SCAF1 ZC3H11A CHERP RNPS1 CDK13 ZRANB2 FNBP4 ZC3H18 NKTR SRRM2 SPEN THRAP3 CLASRP	7.62e-11	292	77	13	int:DHX8
Interaction	NUP43 interactions	ARL6IP4 CCNT2 ZNF703 SCAF1 RNPS1 ASH1L DVL1 CIZ1 MUC19 ICE1 ZC3H18 NKTR SSRP1 ARID1A SRRM2 SPEN NCBP3	1.59e-10	625	77	17	int:NUP43
Interaction	CLK2 interactions	CCNT1 ZC3H11A HIRIP3 RNPS1 SRSF8 ZC3H18 NKTR SRRM2 THRAP3 CLASRP NCBP3	2.01e-10	195	77	11	int:CLK2
Interaction	CLK3 interactions	CCNT1 ZC3H11A CHERP HIRIP3 RNPS1 SRSF8 ZC3H18 TOPORS SRRM2 THRAP3 CLASRP	7.26e-10	220	77	11	int:CLK3
Interaction	SRSF7 interactions	SCAF1 CHERP RNPS1 PPRC1 SRSF8 ZRANB2 ZC3H18 NKTR SRRM2 SPEN ZBTB1 THRAP3 NCBP3	7.34e-09	425	77	13	int:SRSF7
Interaction	SRPK2 interactions	ARL6IP4 SCAF1 CHERP HIRIP3 RNPS1 CDK13 SRSF8 ZRANB2 ZC3H18 NKTR SRRM2 SPEN THRAP3 RSRC1 CLASRP NCBP3	1.01e-08	717	77	16	int:SRPK2
Interaction	SRSF4 interactions	SCAF1 CHERP RNPS1 CDK13 SRSF8 ZC3H18 NKTR TOPORS SRRM2 THRAP3 NCBP3	1.85e-08	300	77	11	int:SRSF4
Interaction	LUC7L interactions	CHERP RNPS1 SRSF8 ZRANB2 ZC3H18 NKTR SRRM2 THRAP3 RSRC1 CLASRP	2.81e-08	242	77	10	int:LUC7L
Interaction	DDX23 interactions	SCAF1 CHERP RNPS1 SUB1 CDK13 ZRANB2 ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1 CLASRP	3.10e-08	480	77	13	int:DDX23
Interaction	SUPT5H interactions	CCNT1 CCNT2 SCAF1 RNPS1 SUB1 ICE1 ZC3H18 SSRP1 ARID1A SPEN THRAP3 NCBP3	4.53e-08	408	77	12	int:SUPT5H
Interaction	PRP4K interactions	CCNT1 CCNT2 ZC3H11A RNPS1 SUB1 ZRANB2 ZC3H18 SSRP1 SRRM2 SPEN THRAP3	4.75e-08	329	77	11	int:PRP4K
Interaction	NCBP2 interactions	PPRC1 PCIF1 ICE1 ZC3H18 LZTS2 SSRP1 SPEN NCBP3	6.59e-08	141	77	8	int:NCBP2
Interaction	SNRPC interactions	ARL6IP4 ZC3H11A RNPS1 PPRC1 SRSF8 ZC3H18 NKTR SSRP1 SRRM2 SPEN THRAP3 NCBP3	1.03e-07	440	77	12	int:SNRPC
Interaction	SNRNP70 interactions	ARL6IP4 CCNT1 CCNT2 SCAF1 ZC3H11A CHERP RNPS1 SRSF8 ZRANB2 ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1 CLASRP NCBP3	1.36e-07	984	77	17	int:SNRNP70
Interaction	CLK1 interactions	HIRIP3 RNPS1 SRSF8 ICE1 ZC3H18 SRRM2 SPEN THRAP3 CLASRP	1.52e-07	219	77	9	int:CLK1
Interaction	NKAPD1 interactions	ARL6IP4 SCAF1 ZC3H11A RNPS1 SRSF8 NKTR SRRM2 THRAP3	1.84e-07	161	77	8	int:NKAPD1
Interaction	PNN interactions	SCAF1 ZC3H11A RNPS1 ZC3H18 NKTR SSRP1 TOPORS SRRM2 THRAP3 NCBP3	2.23e-07	302	77	10	int:PNN
Interaction	SAP18 interactions	SCAF1 RNPS1 SRSF8 ZC3H18 NKTR SSRP1 ARID1A TOPORS SRRM2 THRAP3	2.44e-07	305	77	10	int:SAP18
Interaction	TERF2 interactions	CCNT1 CCNT2 ZNF703 SUB1 CDK13 ZC3H18 SSRP1 SRRM2 THRAP3 CLASRP	6.59e-07	340	77	10	int:TERF2
Interaction	SNRNP40 interactions	CCNT2 SCAF1 CHERP DVL1 CIZ1 ZC3H18 NKTR SSRP1 ARID1A SRRM2 SPEN RSRC1 CLASRP	7.97e-07	637	77	13	int:SNRNP40
Interaction	ZC3H18 interactions	ARL6IP4 ZC3H11A RNPS1 SUB1 SRSF8 ZRANB2 FNBP4 ZC3H18 NKTR SSRP1 TOPORS SRRM2 SPEN THRAP3 RSRC1	9.53e-07	877	77	15	int:ZC3H18
Interaction	CCDC9 interactions	ARL6IP4 ZC3H11A HIRIP3 RNPS1 SRSF8 NCBP3	1.08e-06	88	77	6	int:CCDC9
Interaction	TERF2IP interactions	CCNT1 SUPT3H ZC3H11A ARPP21 CDK13 ZRANB2 CIZ1 ZC3H18 SSRP1 ARID1A SRRM2 SPEN	1.15e-06	552	77	12	int:TERF2IP
Interaction	RAD18 interactions	ARL6IP4 SCAF1 HIRIP3 SUB1 SRSF8 ZRANB2 ZC3H18 SSRP1 SRRM2 SPEN THRAP3	1.26e-06	457	77	11	int:RAD18
Interaction	CFAP20 interactions	RNPS1 ZRANB2 ZC3H18 SRRM2 RSRC1 CLASRP	1.31e-06	91	77	6	int:CFAP20
Interaction	SSRP1 interactions	ARL6IP4 SCAF1 ZC3H11A HIRIP3 RNPS1 SUB1 ZC3H18 SSRP1 ARID1A SRRM2 THRAP3 RSRC1 BRWD1	1.79e-06	685	77	13	int:SSRP1
Interaction	SRPK1 interactions	ARL6IP4 CHERP HIRIP3 RNPS1 SRSF8 ZRANB2 ZC3H18 SSRP1 SRRM2 THRAP3 RSRC1	1.90e-06	477	77	11	int:SRPK1
Interaction	SNRPA interactions	ARL6IP4 ZC3H11A RNPS1 SRSF8 ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1 NCBP3	2.10e-06	482	77	11	int:SNRPA
Interaction	TOP1 interactions	ARL6IP4 CCNT1 SCAF1 ZC3H11A RNPS1 SUB1 ZRANB2 ZC3H18 SSRP1 ARID1A TOPORS SRRM2 THRAP3	2.13e-06	696	77	13	int:TOP1
Interaction	AKAP17A interactions	ZC3H11A RNPS1 ZRANB2 ZC3H18 SRRM2 NCBP3	2.16e-06	99	77	6	int:AKAP17A
Interaction	CSNK2A1 interactions	ARL6IP4 RYBP HIRIP3 RNPS1 SUB1 GYS1 ZRANB2 DVL1 FNBP4 ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1	2.77e-06	956	77	15	int:CSNK2A1
Interaction	GSPT2 interactions	ZC3H11A RNPS1 ZC3H18 SRRM2 THRAP3 NCBP3	3.40e-06	107	77	6	int:GSPT2
Interaction	ZC3H14 interactions	ARL6IP4 ZC3H11A RNPS1 ZC3H18 SSRP1 THRAP3 NCBP3	3.78e-06	169	77	7	int:ZC3H14
Interaction	SNRPB interactions	ARL6IP4 ZC3H11A CHERP RNPS1 FNBP4 ZC3H18 NKTR SRRM2 THRAP3 RSRC1 NCBP3	4.12e-06	517	77	11	int:SNRPB
Interaction	DYRK2 interactions	CCNT1 ZSWIM8 ZRANB2 ZC3H18 LZTS2 SRRM2 CLASRP	4.41e-06	173	77	7	int:DYRK2
Interaction	RNPS1 interactions	ZC3H11A CHERP RNPS1 ZC3H18 NKTR SSRP1 TOPORS SRRM2 THRAP3 NCBP3	4.87e-06	425	77	10	int:RNPS1
Interaction	CAMKV interactions	RNPS1 ZRANB2 ZC3H18 SRRM2 SPEN THRAP3	5.99e-06	118	77	6	int:CAMKV
Interaction	PRPF40A interactions	CCNT1 CHERP RNPS1 CDK13 FNBP4 ZC3H18 SSRP1 SRRM2 SPEN NCBP3	7.44e-06	446	77	10	int:PRPF40A
Interaction	ATXN1 interactions	ARL6IP4 CCNT1 ZSWIM8 RNPS1 SUB1 CDK13 ZRANB2 ZC3H18 EDC4 ARID1A SRRM2 SPEN THRAP3 RSRC1 CLASRP	7.62e-06	1039	77	15	int:ATXN1
Interaction	KIF20A interactions	ARL6IP4 RYBP CHERP TMPRSS13 RNPS1 SRSF8 ZRANB2 FAM83D ZC3H18 SPECC1L SSRP1 SRRM2 STAG3 THRAP3 PRPH	8.84e-06	1052	77	15	int:KIF20A
Interaction	SRSF1 interactions	SCAF1 CHERP RNPS1 SUB1 CDK13 KDM4A ZC3H18 SRRM2 ZBTB1 THRAP3 RSRC1	1.04e-05	570	77	11	int:SRSF1
Interaction	RBBP4 interactions	RYBP JARID2 ASH1L ZC3H18 SSRP1 ARID1A TOPORS SRRM2 SPEN THRAP3 CLASRP	1.09e-05	573	77	11	int:RBBP4
Interaction	SRSF11 interactions	ARL6IP4 RNPS1 ZRANB2 ZC3H18 SRRM2 THRAP3 NCBP3	1.26e-05	203	77	7	int:SRSF11
Interaction	MYCN interactions	ARL6IP4 SCAF1 ZC3H11A CHERP RNPS1 SUB1 CDK13 ZRANB2 ZC3H18 SSRP1 ARID1A SRRM2 MEX3B THRAP3 RSRC1 NCBP3 PRPH	1.30e-05	1373	77	17	int:MYCN
Interaction	SRSF2 interactions	RNPS1 SUB1 SRSF8 ZRANB2 ZC3H18 POC5 LZTS2 SPEN	1.49e-05	290	77	8	int:SRSF2
Interaction	THOC1 interactions	SCAF1 ZC3H11A ZC3H18 SSRP1 SPEN THRAP3 NCBP3	1.57e-05	210	77	7	int:THOC1
Interaction	CHTOP interactions	ZC3H11A CIZ1 KDM4A ZC3H18 POC5 SSRP1 NCBP3	1.66e-05	212	77	7	int:CHTOP
Interaction	PABPC5 interactions	ZC3H11A CHERP SRSF8 ZC3H18 SRRM2 NCBP3	1.73e-05	142	77	6	int:PABPC5
Interaction	ZC3H11A interactions	ZC3H11A RNPS1 SRSF8 ZC3H18 NKTR SSRP1 NCBP3	1.82e-05	215	77	7	int:ZC3H11A
Interaction	ACIN1 interactions	ZC3H11A RNPS1 SUB1 ZRANB2 ZC3H18 SSRP1 SRRM2 THRAP3	1.94e-05	301	77	8	int:ACIN1
Interaction	SMC5 interactions	CCNT1 ZC3H11A CHERP SUB1 FNBP4 CIZ1 ICE1 ZC3H18 SSRP1 ARID1A SRRM2 SPEN THRAP3 NCBP3	2.26e-05	1000	77	14	int:SMC5
Interaction	PURG interactions	SCAF1 ZC3H11A CHERP CDK13 ZC3H18 NKTR EDC4	2.30e-05	223	77	7	int:PURG
Interaction	MECP2 interactions	CCNT1 CCNT2 CHERP SUB1 SRSF8 GYS1 ZRANB2 FNBP4 ZC3H18 NKTR SSRP1 ARID1A SRRM2 SPEN THRAP3 PRPH	2.34e-05	1287	77	16	int:MECP2
Interaction	CLK4 interactions	SUB1 ZC3H18 SRRM2 CLASRP	2.38e-05	44	77	4	int:CLK4
Interaction	CSNK2B interactions	RYBP CHERP HIRIP3 RNPS1 SUB1 ZC3H18 NKTR SSRP1 TOPORS THRAP3 RSRC1	2.44e-05	625	77	11	int:CSNK2B
Interaction	SART1 interactions	CCNT1 CHERP SUB1 ASH1L ZC3H18 SSRP1 SRRM2 THRAP3	2.81e-05	317	77	8	int:SART1
Interaction	NFKBIL1 interactions	RNPS1 ZRANB2 ZC3H18 SRRM2 SPEN	2.85e-05	93	77	5	int:NFKBIL1
Interaction	SRSF3 interactions	SCAF1 ZC3H11A RNPS1 CDK13 SRSF8 ZC3H18 SRRM2 SPEN THRAP3 NCBP3	2.89e-05	522	77	10	int:SRSF3
Interaction	ZNF816 interactions	ZC3H18 NKTR TOPORS	2.90e-05	16	77	3	int:ZNF816
Interaction	MEN1 interactions	CCNT1 ZC3H11A CHERP RNPS1 FNBP4 ZC3HC1 ZC3H18 EDC4 SSRP1 ARID1A SRRM2 SPEN THRAP3 NCBP3	3.10e-05	1029	77	14	int:MEN1
Interaction	PIP4K2C interactions	ARL6IP4 CHERP RNPS1 ZRANB2 LZTS2 MEX3B	3.28e-05	159	77	6	int:PIP4K2C
Interaction	U2AF2 interactions	SCAF1 CHERP RNPS1 SRSF8 ZRANB2 ZC3H18 NKTR SRRM2 MEX3B THRAP3 CLASRP	3.54e-05	651	77	11	int:U2AF2
Interaction	LARP4B interactions	SCAF1 ZC3H11A CHERP SRSF8 SRRM2 MEX3B NCBP3	3.68e-05	240	77	7	int:LARP4B
Interaction	TRA2A interactions	ZC3H11A RNPS1 SRSF8 ZC3H18 SSRP1 SRRM2 THRAP3 NCBP3	3.74e-05	330	77	8	int:TRA2A
Interaction	PQBP1 interactions	ZC3H11A ZC3H18 LZTS2 SSRP1 RSRC1	5.12e-05	105	77	5	int:PQBP1
Interaction	DOT1L interactions	CCNT1 ZC3H11A CHERP RNPS1 ZRANB2 FNBP4 ZC3H18 SPECC1L SSRP1 SRRM2 THRAP3 RSRC1	5.26e-05	807	77	12	int:DOT1L
Interaction	ZBTB2 interactions	ARL6IP4 SCAF1 RNPS1 SRSF8 ZC3H18 NKTR SSRP1 ZBTB1 THRAP3	5.36e-05	450	77	9	int:ZBTB2
Interaction	CRNKL1 interactions	ZC3H11A RNPS1 ZC3H18 LZTS2 SSRP1 SPEN	5.97e-05	177	77	6	int:CRNKL1
Interaction	LUC7L2 interactions	RNPS1 SRSF8 ZRANB2 ZC3H18 SRRM2 THRAP3 CLASRP NCBP3	6.02e-05	353	77	8	int:LUC7L2
Interaction	ARL6IP4 interactions	ARL6IP4 ZRANB2 ZC3H18 SSRP1 NCBP3	6.12e-05	109	77	5	int:ARL6IP4
Interaction	COMMD6 interactions	CHERP SUB1 SSRP1 RSRC1	6.67e-05	57	77	4	int:COMMD6
Interaction	SREK1 interactions	ARL6IP4 RNPS1 SRSF8 ZRANB2 SSRP1 THRAP3	7.18e-05	183	77	6	int:SREK1
Interaction	THOC7 interactions	SCAF1 ZC3H11A ZC3H18 SSRP1 NCBP3	7.57e-05	114	77	5	int:THOC7
Interaction	ELAVL2 interactions	ZC3H11A RNPS1 SRSF8 ZC3H18 SRRM2 NCBP3	8.33e-05	188	77	6	int:ELAVL2
Interaction	CSNK2A2 interactions	ARL6IP4 RYBP HIRIP3 RNPS1 ASH1L ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1	8.54e-05	718	77	11	int:CSNK2A2
Interaction	SNRPF interactions	ZC3H11A CHERP ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1	1.10e-04	385	77	8	int:SNRPF
Interaction	TOP3B interactions	SCAF1 ZC3H11A PPRC1 SUB1 CDK13 TMCC2 DVL1 MTMR3 KDM4A ICE1 EDC4 SSRP1 ARID1A SPEN MEX3B TIAM2	1.15e-04	1470	77	16	int:TOP3B
Interaction	NELFE interactions	SUB1 SRSF8 PCIF1 SSRP1 THRAP3 RSRC1	1.20e-04	201	77	6	int:NELFE
Interaction	PRPF3 interactions	RNPS1 CDK13 ZC3H18 SSRP1 SRRM2 SPEN THRAP3	1.24e-04	291	77	7	int:PRPF3
Interaction	H3-3A interactions	CCNT1 HIRIP3 RNPS1 SUB1 ASH1L KDM4A SSRP1 SPEN THRAP3 NCBP3 BRWD1	1.24e-04	749	77	11	int:H3-3A
Interaction	ELL3 interactions	CCNT1 CCNT2 ICE1	1.31e-04	26	77	3	int:ELL3
Interaction	CEP164 interactions	RNPS1 GYS1 LZTS2 SSRP1 NCBP3	1.31e-04	128	77	5	int:CEP164
Interaction	JPH4 interactions	ZSWIM8 CDK13 ZC3H18 CLASRP	1.33e-04	68	77	4	int:JPH4
Interaction	RBM39 interactions	ARL6IP4 ZC3H11A CHERP RNPS1 FNBP4 ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1 NCBP3 PRPH	1.48e-04	1042	77	13	int:RBM39
Interaction	SNRPA1 interactions	CHERP RNPS1 ICE1 ZC3H18 SRRM2 ZBTB1 THRAP3	1.49e-04	300	77	7	int:SNRPA1
Interaction	OBSL1 interactions	SCAF1 ZC3H11A CHERP RNPS1 ZRANB2 CIZ1 EDC4 SSRP1 SRRM2 SPEN THRAP3 NCBP3	1.51e-04	902	77	12	int:OBSL1
Interaction	NKAP interactions	RNPS1 ZC3H18 NKTR TOPORS SRRM2	1.51e-04	132	77	5	int:NKAP
Interaction	CPSF6 interactions	ARL6IP4 CCNT1 ZC3H11A RNPS1 ZC3H18 NKTR SRRM2 THRAP3 NCBP3	1.75e-04	526	77	9	int:CPSF6
Interaction	BMI1 interactions	RYBP ZC3H11A CHERP RNPS1 CIZ1 EDC4 SPEN THRAP3 RSRC1 NCBP3	1.99e-04	659	77	10	int:BMI1
Interaction	ARRDC3 interactions	CCNT1 CHERP RNPS1 ZC3H18 SPEN THRAP3	2.17e-04	224	77	6	int:ARRDC3
Interaction	CEBPA interactions	ARL6IP4 CCNT1 CCNT2 ZC3H11A RNPS1 SUB1 CDK13 ZRANB2 EDC4 SSRP1 ARID1A SRRM2 SPEN THRAP3	2.36e-04	1245	77	14	int:CEBPA
Interaction	CDK12 interactions	RNPS1 CDK13 ZC3H18 SRRM2 SPEN THRAP3	2.38e-04	228	77	6	int:CDK12
Interaction	YWHAG interactions	USP31 RNPS1 SUB1 SRSF8 MTMR3 NKTR SPECC1L EDC4 LZTS2 SRRM2 MEX3B THRAP3 RSRC1 ITPKB	2.42e-04	1248	77	14	int:YWHAG
Interaction	BCLAF1 interactions	JARID2 ZC3H11A ZC3H18 SSRP1 SPEN ZBTB1 THRAP3	2.53e-04	327	77	7	int:BCLAF1
Interaction	CD2BP2 interactions	ZC3H18 NKTR SSRP1 SRRM2 THRAP3 RSRC1	2.62e-04	232	77	6	int:CD2BP2
Interaction	ELL2 interactions	CCNT1 CCNT2 ICE1	2.69e-04	33	77	3	int:ELL2
Interaction	RTF1 interactions	ZRANB2 ZC3H18 SSRP1 ARID1A SRRM2	2.74e-04	150	77	5	int:RTF1
GeneFamily	CD molecules\|Mucins	MUC19 MUC16 MUC6	2.56e-05	21	50	3	648
GeneFamily	Cyclins\|P-TEFb complex	CCNT1 CCNT2	4.48e-05	4	50	2	1281
GeneFamily	Zinc fingers CCCH-type	ZC3H11A ZC3H11B ZC3H18	1.22e-04	35	50	3	73
GeneFamily	AT-rich interaction domain containing	JARID2 ARID1A	7.69e-04	15	50	2	418
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RYBP ZRANB2	1.52e-03	21	50	2	89
GeneFamily	Cyclins	CCNT1 CCNT2	2.71e-03	28	50	2	473
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	JARID2 CCNT2 ZC3H11A SUB1 CDK13 RGCC ASH1L FNBP4 TMF1 ICE1 DENND1C ARID1A SPEN ZBTB1 THRAP3 ITPKB BRWD1	1.44e-06	1492	78	17	M40023
Coexpression	GSE14769_40MIN_VS_360MIN_LPS_BMDM_DN	CCNT1 ZSWIM8 PPRC1 SPECC1L ARID1A SPEN THRAP3	2.19e-06	199	78	7	M3517
Coexpression	GSE7568_IL4_TGFB_DEXAMETHASONE_VS_IL4_TGFB_TREATED_MACROPHAGE_DN	ZC3H11A SUB1 TMF1 ICE1 ITPKB BRWD1	1.40e-05	175	78	6	M371
Coexpression	GSE19888_CTRL_VS_A3R_ACTIVATION_MAST_CELL_UP	CCNT2 MTMR3 FAM83D THRAP3 TIAM2 PRPH	2.90e-05	199	78	6	M7325
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_7DY_DN	RYBP JARID2 CCNT2 SUB1 PCIF1 MTMR3 TMF1 SPECC1L TOPORS ZBTB1 ITPKB	3.93e-05	844	78	11	M41129
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	SCAF1 RNPS1 PPRC1 FNBP4 KDM4A SRRM2 CLASRP	6.72e-05	338	78	7	M17094
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNT1 CDK13 DDHD1 ASH1L ZRANB2 NKTR	1.37e-06	199	78	6	f0b0097df0026496470a80d8cc9375ffd8389b00
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	HIRIP3 PPRC1 PCIF1 ARID1A SRRM2 ZBTB1 ITPKB	1.70e-06	169	77	7	5572_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	HIRIP3 PPRC1 PCIF1 ARID1A SRRM2 ZBTB1 ITPKB	2.59e-06	180	77	7	6454_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	HIRIP3 CDK13 KDM4A ARID1A SRRM2 ZBTB1 ITPKB	2.59e-06	180	77	7	5981_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	HIRIP3 PPRC1 PCIF1 ARID1A SRRM2 ZBTB1	2.19e-05	167	77	6	5217_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	HIRIP3 PPRC1 PCIF1 ARID1A ZBTB1 ITPKB	2.59e-05	172	77	6	2330_DN
Drug	HC toxin from Helminthosporium carbonum; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	HIRIP3 PPRC1 ARID1A SRRM2 ZBTB1 ITPKB	2.77e-05	174	77	6	909_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA	HIRIP3 PPRC1 CDK13 ARID1A SRRM2 ZBTB1	2.86e-05	175	77	6	1014_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	HIRIP3 PCIF1 ARID1A SRRM2 ZBTB1 ITPKB	2.95e-05	176	77	6	6546_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	CCNT1 CDK13 ARID1A SRRM2 ZBTB1 BRWD1	3.14e-05	178	77	6	5086_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	CCNT2 HIRIP3 PPRC1 ARID1A SRRM2 ZBTB1	3.24e-05	179	77	6	5822_DN
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A	CCNT1 ZSWIM8 HIRIP3 SPECC1L SPEN STAG3	5.53e-05	197	77	6	7011_DN
Drug	Chlorpropamide [94-20-2]; Up 200; 14.4uM; HL60; HG-U133A	JARID2 CCNT1 CHERP CDK13 CIZ1 SPEN	5.69e-05	198	77	6	1594_UP
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Up 200; 2.8uM; HL60; HG-U133A	CHERP TMCC2 PCIF1 FGA STAG3 PRPH	5.69e-05	198	77	6	1391_UP
Disease	body mass index, osteoarthritis	SUPT3H OLFM4 ZC3H11B BRWD1	1.17e-05	54	76	4	EFO_0004340, MONDO_0005178
Disease	serum gamma-glutamyl transferase measurement	RASIP1 ARPP21 ASH1L PCIF1 SLC9A7 ZC3H11B SPECC1L LZTS2 ARID1A MUC6	1.16e-04	914	76	10	EFO_0004532
Disease	Alzheimer disease, polygenic risk score	FNBP4 MTMR3 MUC19 SSRP1 STAG3 CLASRP ITPKB	7.87e-04	586	76	7	EFO_0030082, MONDO_0004975
Disease	otosclerosis	SUPT3H ZC3H11B MEX3B	1.21e-03	81	76	3	EFO_0004213
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	ZC3H11B BRWD1	1.33e-03	21	76	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	Sjogren's syndrome (is_marker_for)	MUC19 MUC16	1.74e-03	24	76	2	DOID:12894 (is_marker_for)
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	PCIF1 ZC3H11B SPECC1L ARID1A	2.71e-03	224	76	4	EFO_0004530, EFO_0008317
Disease	osteoarthritis, hip, body mass index	SUPT3H ZC3H11B	2.72e-03	30	76	2	EFO_0004340, EFO_1000786

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPTRKRSSSESTSST	ASH1L	1681	Q9NR48
SSDGISSSSSSSRKR	CCNT2	606	O60583
RRSSTSGSLETTSSK	CATSPER4	421	Q7RTX7
STGTASSTKRSTSTG	SPECC1L	101	Q69YQ0
STSTGNKESSSTRER	SPECC1L	111	Q69YQ0
LSSSFSSSSSTRKRG	CCNT1	561	O60563
ASSLDATSSSKDSRS	DENND1C	626	Q8IV53
SRLKRSDGSTTSTSF	CACNB4	31	O00305
SSSSGGRRKSASATS	CDK13	251	Q14004
GRRKSASATSSSSSS	CDK13	256	Q14004
ASATSSSSSSRKDRD	CDK13	261	Q14004
TRGDSTSSTRSTGKL	ARPP21	391	Q9UBL0
SAASVKSSSSDTGSR	RASIP1	41	Q5U651
VASSDSSISSKARGS	EDC4	101	Q6P2E9
STRSSTLTEDGAKSS	ARID1A	1916	O14497
GSSDILRATTSSTSK	MUC16	501	Q8WXI7
SGTSQSRSSFSTAKT	MUC6	1731	Q6W4X9
ESSTSASRSLGTRSA	POC5	546	Q8NA72
SRKGRTRSSSSSSDG	HIRIP3	391	Q9BW71
SDSGRSSSSKSTGSL	LZTS2	271	Q9BRK4
SSDGTTGTTRKSTAR	MUC19	2561	Q7Z5P9
SSSRFSSSRLLGSAS	PRPH	36	P41219
RSSSLKSSSSVSSQG	FAM83D	471	Q9H4H8
RSASRRSSASSSDSD	NCBP3	386	Q53F19
KKSSSSLGSGSSRDS	KDM4A	506	O75164
STTRGSSEKSTTAFS	IGSF10	1041	Q6WRI0
SSGKRTLSTSTLRSA	ICE1	1831	Q9Y2F5
SGSSSSSSSEAKDRD	PCIF1	676	Q9H4Z3
SRSNSRSSKSSGSYS	CHERP	751	Q8IWX8
SSSSSSSSDGRKKRG	ARL6IP4	91	Q66PJ3
SKESSRARESSSRSG	BRWD1	1551	Q9NSI6
SGSTTTTRRSCSKTV	FGA	451	P02671
RTGRKNSSTSTSSSG	GPR161	236	Q8N6U8
EGSKSSGSTRSSRRA	DVL1	571	O14640
GRSSTTQSSETSKDS	DDHD1	766	Q8NEL9
SRSSSPDLSSSSKLT	FRY	1936	Q5TBA9
RASCTSSTSGSKRNS	GYS1	696	P13807
SSSGRSRRCSSSSSS	PPRC1	1471	Q5VV67
CASDSRSSGSKLSTR	MTMR3	261	Q13615
SRLSASSSSKSASSS	JARID2	1231	Q92833
ASGRRRTSSTDSESK	PPP1R14D	26	Q9NXH3
SSSSSSSSGLRRKGS	MEX3B	501	Q6ZN04
RSASSGSSSTRSRSS	RNPS1	66	Q15287
ADSASSSDTSRSRSR	SRRM2	266	Q9UQ35
PAKERRSSSSSSSSS	SRRM2	2526	Q9UQ35
SGSSSRRTKSSSLEP	TMCC2	176	O75069
GRRSSSDTSKSTYSL	SYT17	91	Q9BSW7
TANSSSSGSKNRSRS	TMEM200C	101	A6NKL6
RATSPESTSRSSSKT	FNBP4	461	Q8N3X1
SSSHSRSRSKSRSSS	NKTR	541	P30414
RKLSSSSASSTGFSS	ITPKB	596	P27987
SGSESTDKGSSRSST	RYBP	201	Q8N488
SRALSSSKQSSSSRD	SUB1	46	P53999
KSGSSTSSRSASTSK	SRSF8	211	Q9BRL6
TSSRSASTSKSSSAR	SRSF8	216	Q9BRL6
ASTSKSSSARRSKSS	SRSF8	221	Q9BRL6
LSISSTSGRSKAFST	OR8S1	226	Q8NH09
FSSSSRSGSSSSRSL	OLFM4	46	Q6UX06
GSSSKSSSRQLSESF	SSRP1	646	Q08945
SSGSRSSRSGSSSTR	CLMP	291	Q9H6B4
ASARRRSSSSSSSSS	CLASRP	371	Q8N2M8
ASRTSSSRSSSRSSS	CLASRP	386	Q8N2M8
RTSSSTTPNRKDSSS	CIZ1	186	Q9ULV3
KRARLCSSSSSDTSS	ZC3HC1	401	Q86WB0
SSASSRQETTDSKSS	TMF1	271	P82094
SDKSSSDRSRRSSSS	THRAP3	146	Q9Y2W1
SRKDSGSSSVSSTSS	ZNF703	166	Q9H7S9
SGRSSSARSASVTTS	TMPRSS13	101	Q9BYE2
TATSSSGRSTGKSIS	SUPT3H	11	O75486
TDSRLRSSKGSSLSS	TIAM2	231	Q8IVF5
GSGSRSRSSSSDSIS	SPEN	271	Q96T58
DTKRALSASSSSSAS	STAG3	11	Q9UJ98
AASSSSSSREKGSRR	SCAF1	756	Q9H7N4
KRRSSASVSDSSGFS	RGCC	61	Q9H4X1
SKTDDSTSGARSSST	ZC3H11A	386	O75152
TRRDSVDSKSSASSS	TCEA3	126	O75764
SSSSSDSRTYSRKKG	RSRC1	26	Q96IZ7
SKTDDSTSGARSSST	ZC3H11B	386	A0A1B0GTU1
SRSSSRSSSPSSSRS	ZRANB2	211	O95218
AADDSASTTGSRKSS	ZBTB1	291	Q9Y2K1
SSDSLGSSSSSGSRR	ZSWIM8	1186	A7E2V4
SLSSESTSRSRSRSS	TOPORS	661	Q9NS56
SRSRSKADSSSRGSG	USP31	1071	Q70CQ4
ASTSLEGSRRTKSSS	SLC9A7	681	Q96T83
RRKTSASSASASNSS	ZC3H18	541	Q86VM9
SFSGSRSRSRSFSSS	ZC3H18	591	Q86VM9