Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K36 trimethyltransferase activity

SETD5 ASH1L

8.56e-065192GO:0140955
GeneOntologyMolecularFunctionhistone H3K9 monomethyltransferase activity

SETD5 ASH1L

2.39e-058192GO:0140948
GeneOntologyMolecularFunctionhistone H3K9me2 methyltransferase activity

SETD5 ASH1L

3.84e-0510192GO:0140947
GeneOntologyMolecularFunctionhistone H3K9 methyltransferase activity

SETD5 ASH1L

6.65e-0513192GO:0046974
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

SETD5 ASH1L

6.65e-0513192GO:0046975
GeneOntologyMolecularFunctionchromatin binding

PRDM15 CHD6 CHD4 ZFY ASH1L

5.17e-04739195GO:0003682
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD6 CHD4

5.60e-0437192GO:0140658
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SETD5 ASH1L

7.92e-0444192GO:0140938
GeneOntologyMolecularFunctionmethyltransferase activity

PRDM15 SETD5 ASH1L

1.02e-03213193GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

PRDM15 SETD5 ASH1L

1.18e-03224193GO:0016741
GeneOntologyMolecularFunctiontranscription corepressor activity

SETD5 ZNF653 CHD4

1.26e-03229193GO:0003714
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SETD5 ASH1L

1.88e-0368192GO:0016279
GeneOntologyMolecularFunctionhistone binding

SETD5 CHD6 CHD4

1.91e-03265193GO:0042393
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SETD5 ASH1L

1.94e-0369192GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETD5 ASH1L

2.05e-0371192GO:0042054
GeneOntologyMolecularFunctionprotein methyltransferase activity

SETD5 ASH1L

4.26e-03103192GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

SETD5 ASH1L

4.42e-03105192GO:0008170
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

CHD6 CHD4

6.39e-03127192GO:0008094
GeneOntologyMolecularFunctiontranscription coregulator binding

CHD6 CHD4

7.72e-03140192GO:0001221
GeneOntologyMolecularFunctionhelicase activity

CHD6 CHD4

9.74e-03158192GO:0004386
GeneOntologyMolecularFunctionchromatin DNA binding

CHD4 ZFY

1.08e-02167192GO:0031490
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

SETD5 ASH1L

1.15e-02172192GO:0008757
GeneOntologyCellularComponenttranscription elongation factor complex

ELOF1 NUFIP1

1.17e-0356192GO:0008023
GeneOntologyCellularComponentnuclear chromosome

PINX1 SETD5 NUFIP1

1.49e-03254193GO:0000228
GeneOntologyCellularComponentchromatin

WDR76 SETD5 CHD6 CHD4 ZFY NUFIP1

1.52e-031480196GO:0000785
GeneOntologyCellularComponenthistone deacetylase complex

SETD5 CHD4

2.67e-0385192GO:0000118
GeneOntologyCellularComponentsite of DNA damage

WDR76 CHD4

6.78e-03137192GO:0090734
MousePhenoabnormal prenatal body size

PDGFA PINX1 PRDM15 SETD5 ELOF1 ZFY ZFP91

7.37e-051116157MP:0010866
MousePhenothick ventricular wall

PDGFA PRDM15 CHD4

1.15e-0491153MP:0002953
DomainSET

PRDM15 SETD5 ASH1L

1.11e-0546183SM00317
DomainSET_dom

PRDM15 SETD5 ASH1L

1.43e-0550183IPR001214
DomainSET

PRDM15 SETD5 ASH1L

1.43e-0550183PS50280
DomainChromo_domain

CHD6 CHD4

2.39e-0424182IPR023780
DomainChromo

CHD6 CHD4

2.81e-0426182PF00385
DomainAT_hook

ZNF653 ASH1L

3.04e-0427182SM00384
DomainAT_hook_DNA-bd_motif

ZNF653 ASH1L

3.04e-0427182IPR017956
DomainCHROMO_2

CHD6 CHD4

3.27e-0428182PS50013
DomainCHROMO_1

CHD6 CHD4

3.27e-0428182PS00598
Domainzf-C2H2

PRDM15 ZNF653 ZFY NUFIP1 ZFP91

3.97e-04693185PF00096
DomainSNF2_N

CHD6 CHD4

4.28e-0432182PF00176
DomainSNF2_N

CHD6 CHD4

4.28e-0432182IPR000330
DomainChromodomain-like

CHD6 CHD4

4.28e-0432182IPR016197
DomainCHROMO

CHD6 CHD4

4.55e-0433182SM00298
DomainChromo/shadow_dom

CHD6 CHD4

4.55e-0433182IPR000953
DomainDNA/RNA_helicase_DEAH_CS

CHD6 CHD4

5.12e-0435182IPR002464
DomainBROMODOMAIN_1

ASH1L BRWD1

5.73e-0437182PS00633
DomainBromodomain

ASH1L BRWD1

6.04e-0438182PF00439
DomainDEAH_ATP_HELICASE

CHD6 CHD4

6.04e-0438182PS00690
DomainZINC_FINGER_C2H2_2

PRDM15 ZNF653 ZFY NUFIP1 ZFP91

6.63e-04775185PS50157
DomainZINC_FINGER_C2H2_1

PRDM15 ZNF653 ZFY NUFIP1 ZFP91

6.70e-04777185PS00028
DomainBROMODOMAIN_2

ASH1L BRWD1

7.04e-0441182PS50014
DomainSET

SETD5 ASH1L

7.04e-0441182PF00856
DomainBROMO

ASH1L BRWD1

7.38e-0442182SM00297
DomainBromodomain

ASH1L BRWD1

7.38e-0442182IPR001487
Domain-

ASH1L BRWD1

7.38e-04421821.20.920.10
DomainZnf_C2H2-like

PRDM15 ZNF653 ZFY NUFIP1 ZFP91

7.48e-04796185IPR015880
DomainZnf_C2H2

PRDM15 ZNF653 ZFY NUFIP1 ZFP91

7.87e-04805185IPR007087
DomainZnF_C2H2

PRDM15 ZNF653 ZFY NUFIP1 ZFP91

8.01e-04808185SM00355
DomainZinc_finger_PHD-type_CS

CHD4 ASH1L

1.76e-0365182IPR019786
DomainPHD

CHD4 ASH1L

2.34e-0375182PF00628
DomainZnf_PHD-finger

CHD4 ASH1L

2.59e-0379182IPR019787
DomainPHD

CHD4 ASH1L

3.27e-0389182SM00249
DomainZnf_PHD

CHD4 ASH1L

3.41e-0391182IPR001965
Domain-

PRDM15 ZNF653 ZFY ZFP91

3.53e-036791843.30.160.60
DomainZF_PHD_2

CHD4 ASH1L

3.71e-0395182PS50016
DomainZF_PHD_1

CHD4 ASH1L

3.79e-0396182PS01359
DomainZnf_C2H2/integrase_DNA-bd

PRDM15 ZNF653 ZFY ZFP91

3.81e-03694184IPR013087
DomainHelicase_C

CHD6 CHD4

4.69e-03107182PF00271
DomainHELICc

CHD6 CHD4

4.69e-03107182SM00490
DomainHelicase_C

CHD6 CHD4

4.77e-03108182IPR001650
DomainHELICASE_CTER

CHD6 CHD4

4.86e-03109182PS51194
DomainHELICASE_ATP_BIND_1

CHD6 CHD4

4.86e-03109182PS51192
DomainDEXDc

CHD6 CHD4

4.86e-03109182SM00487
DomainHelicase_ATP-bd

CHD6 CHD4

4.95e-03110182IPR014001
DomainZnf_FYVE_PHD

CHD4 ASH1L

8.67e-03147182IPR011011
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

CHD4 ASH1L BRWD1

2.12e-04175103MM14941
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

CHD4 ASH1L BRWD1

7.71e-04272103M29619
PathwayWP_HISTONE_MODIFICATIONS

SETD5 ASH1L

9.20e-0465102M39374
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

WDR76 PINX1 PRDM15 CHD6 CHD4 ZFP91 BRWD1

3.07e-0860820736089195
Pubmed

CHD chromatin remodelling enzymes and the DNA damage response.

CHD6 CHD4

3.14e-07220223954449
Pubmed

The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.

SETD5 CHD4

9.42e-07320231474762
Pubmed

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

SETD5 ASH1L

3.14e-06520222939622
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

CHD4 ASH1L BRWD1

1.07e-057520325593309
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

WDR76 PINX1 PRDM15 CHD6 ZFP91

2.66e-0564520525281560
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SETD5 CHD4 NUFIP1 ZFP91 ASH1L BRWD1

2.84e-05111620631753913
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

CHD6 CHD4 ASH1L

9.72e-0515720330186101
Pubmed

Isolation and characterization of proteins associated with histone H3 tails in vivo.

CHD4 ASH1L

1.35e-043020217403666
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

SETD5 CHD4 ZFY ASH1L

2.17e-0453320430554943
Pubmed

Novel Cul3 binding proteins function to remodel E3 ligase complexes.

WDR76 BRWD1

2.42e-044020225011449
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

PINX1 CHD4 ZFP91

3.73e-0424820327926873
InteractionH3-3A interactions

WDR76 PINX1 PRDM15 CHD4 ZFP91 ASH1L BRWD1

4.83e-06749207int:H3-3A
InteractionH3C3 interactions

WDR76 PINX1 PRDM15 CHD6 CHD4 ZFP91

6.16e-06495206int:H3C3
InteractionH2BC8 interactions

WDR76 PINX1 PRDM15 CHD6 CHD4 ZFP91

1.46e-05576206int:H2BC8
InteractionBRD3 interactions

WDR76 SETD5 CHD4 ZFY ZFP91

9.91e-05494205int:BRD3
Cytoband19p13.2

ZNF653 ELOF1

4.44e-0322920219p13.2
CytobandEnsembl 112 genes in cytogenetic band chr21q22

PRDM15 BRWD1

1.16e-02377202chr21q22
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

PRDM15 ZNF653 ZFY ZFP91

6.51e-0471811428
GeneFamilyPHD finger proteins

CHD4 ASH1L

1.31e-039011288
GeneFamilyWD repeat domain containing

WDR76 BRWD1

1.06e-02262112362
ToppCellcritical-Epithelial-unknown_epithelial|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDGFA PINX1 NUFIP1

4.90e-05161203594cf3245ec065a7685db81cd8ba2cee8d42caac
ToppCellNS-critical-d_16-33-Epithelial-unknown_epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDGFA PINX1 NUFIP1

5.97e-05172203c0b5e4889aef2f168d9f6db19a63b24bfd249316
ToppCellcritical-Epithelial-unknown_epithelial|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDGFA PINX1 NUFIP1

6.07e-051732034144b1cdefa8c37b6ac7a6d249fa5292ffb2b8b2
ToppCellNS-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDGFA PINX1 NUFIP1

7.53e-05186203c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PINX1 ASH1L BRWD1

9.33e-05200203dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

WDR76 PDGFA CHD4 ASH1L

1.69e-051911946020_DN
DrugScopolamine hydrochloride [55-16-3]; Down 200; 11.8uM; PC3; HT_HG-U133A

WDR76 PDGFA ASH1L BRWD1

1.79e-051941944219_DN
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

WDR76 PDGFA CHD4 ASH1L

1.87e-051961941708_DN
Diseasewhite matter hyperintensity measurement

PRDM15 CHD6 CC2D2B

9.11e-04302193EFO_0005665
DiseaseNeurodevelopmental Disorders

SETD5 ASH1L

1.62e-0393192C1535926
Diseasefatty acid measurement

PINX1 NUFIP1 BRWD1

2.60e-03436193EFO_0005110
Diseasepuberty onset measurement

PDGFA BRWD1

2.90e-03125192EFO_0005677
DiseaseIGF-1 measurement

WDR76 PINX1 NUFIP1

3.58e-03488193EFO_0004627
Diseaseautism spectrum disorder (implicated_via_orthology)

CHD6 ASH1L

4.26e-03152192DOID:0060041 (implicated_via_orthology)
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

PINX1 BRWD1

5.05e-03166192EFO_0004530, EFO_0004611
Diseasebreast cancer (is_marker_for)

PDGFA SETD5

6.23e-03185192DOID:1612 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
IRKPDLKKKRGRPPK

ASH1L

1341

Q9NR48
PRRKLKPQRKERKKV

CC2D2B

836

Q6DHV5
MGRRKSKRKPPPKKK

ELOF1

1

P60002
LKPKKRRGKKKLQKP

PINX1

291

Q96BK5
SKDREPKPKRKREPK

CHD6

111

Q8TD26
PPKRRRKRKKENKPK

BRWD1

906

Q9NSI6
FRKLLKKRAPPAPKK

IGFN1

146

Q86VF2
KPKKPRDPKIPKSKR

CHD4

56

Q14839
PSQIPKRKRKAKKRR

TMEM200C

21

A6NKL6
KEQKKKPRRGRKPKV

PRDM15

626

P57071
RTKPKKRKKSPEKGR

SETD5

166

Q9C0A6
KIIREPRKKRVPKKP

HERC2P3

276

Q9BVR0
KPWEQVPKKPKRKKR

ZNF653

101

Q96CK0
VPKKPKRKKRRRRNV

ZNF653

106

Q96CK0
LPPSRKQKKKKRKEP

NUFIP1

156

Q9UHK0
PRESGKKRKRKRLKP

PDGFA

196

P04085
RQPPKSKRKKPKREN

WDR76

196

Q9H967
RKDDKSPRLPKRRKK

ZFP91

291

Q96JP5
RREKPRRKKRPAKQP

VWA3B

1201

Q502W6
LGRLAKQKPKKKRRP

ZFY

386

P08048
LLPKRKRFRKKKSRP

PP2D1

31

A8MPX8