Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 PLXNB3 CDHR4	3.17e-09	187	163	13	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	NRG1 FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 UNC5D PLXNB3 EPHA3 CDHR4	4.02e-09	313	163	16	GO:0098742
GeneOntologyBiologicalProcess	cell-cell adhesion	NPHS1 NRG1 FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 ITGB7 TYRO3 CELSR1 PBRM1 CELSR3 CELSR2 CD86 DCHS1 TLN2 DSG4 ZP4 UNC5D PLXNB3 VCL EPHA3 CDHR4	4.18e-06	1077	163	24	GO:0098609
GeneOntologyCellularComponent	apical part of cell	NRG1 FAT4 ANK2 ACY3 SLC6A19 MPDZ DUOX2 SLC34A3 PTCH1 C2CD2L SLC6A9 KCNA5 SLC13A1 CSPG4 DCHS1 STK39	1.79e-05	592	164	16	GO:0045177
GeneOntologyCellularComponent	apical plasma membrane	NRG1 ANK2 ACY3 SLC6A19 MPDZ DUOX2 SLC34A3 C2CD2L SLC6A9 KCNA5 SLC13A1 CSPG4 STK39	1.27e-04	487	164	13	GO:0016324
GeneOntologyCellularComponent	RAVE complex	DMXL2 DMXL1	1.83e-04	3	164	2	GO:0043291
GeneOntologyCellularComponent	intercalated disc	ANK2 OBSL1 KCNA5 TLN2 VCL	1.96e-04	68	164	5	GO:0014704
Domain	Cadherin_CS	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	1.47e-10	109	159	12	IPR020894
Domain	CADHERIN_1	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	2.25e-10	113	159	12	PS00232
Domain	Cadherin	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	2.25e-10	113	159	12	PF00028
Domain	CADHERIN_2	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	2.49e-10	114	159	12	PS50268
Domain	-	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	2.49e-10	114	159	12	2.60.40.60
Domain	CA	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	2.76e-10	115	159	12	SM00112
Domain	Cadherin-like	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	3.06e-10	116	159	12	IPR015919
Domain	Cadherin	FAT4 PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2 DCHS1 DSG4 CDHR4	3.74e-10	118	159	12	IPR002126
Domain	LAM_G_DOMAIN	FAT4 COL27A1 CELSR1 CELSR3 CELSR2 CSPG4	7.63e-07	38	159	6	PS50025
Domain	Laminin_G	FAT4 COL27A1 CELSR1 CELSR3 CELSR2 CSPG4	9.72e-06	58	159	6	IPR001791
Domain	Laminin_G_2	FAT4 CELSR1 CELSR3 CELSR2 CSPG4	2.17e-05	40	159	5	PF02210
Domain	LamG	FAT4 CELSR1 CELSR3 CELSR2 CSPG4	3.49e-05	44	159	5	SM00282
Domain	FN3	NPHS1 COL6A3 FNDC5 OBSL1 CMYA5 TYRO3 ATF7IP2 EPHA3 EPHA5	5.30e-05	199	159	9	PS50853
Domain	Mad3_BUB1_I	BUB1 BUB1B	7.20e-05	2	159	2	PF08311
Domain	Mad3_BUB1_I	BUB1 BUB1B	7.20e-05	2	159	2	SM00777
Domain	BUB1_N	BUB1 BUB1B	7.20e-05	2	159	2	PS51489
Domain	Bub1/Mad3	BUB1 BUB1B	7.20e-05	2	159	2	IPR015661
Domain	Mad3/Bub1_I	BUB1 BUB1B	7.20e-05	2	159	2	IPR013212
Domain	Rav1p_C	DMXL2 DMXL1	7.20e-05	2	159	2	IPR022033
Domain	Rav1p_C	DMXL2 DMXL1	7.20e-05	2	159	2	PF12234
Domain	FN3_dom	NPHS1 COL6A3 FNDC5 OBSL1 CMYA5 TYRO3 ATF7IP2 EPHA3 EPHA5	7.74e-05	209	159	9	IPR003961
Domain	GAIN_dom_N	CELSR1 CELSR3 CELSR2	9.50e-05	11	159	3	IPR032471
Domain	GAIN	CELSR1 CELSR3 CELSR2	9.50e-05	11	159	3	PF16489
Domain	ConA-like_dom	PTX4 FAT4 COL27A1 BSPRY CMYA5 CELSR1 CELSR3 CELSR2 CSPG4	1.11e-04	219	159	9	IPR013320
Domain	-	PTX4 FAT4 CELSR1 CELSR3 CELSR2 CSPG4	1.61e-04	95	159	6	2.60.120.200
Domain	FN3	NPHS1 COL6A3 FNDC5 OBSL1 CMYA5 TYRO3 EPHA3 EPHA5	1.89e-04	185	159	8	SM00060
Domain	CLCA_chordata	CLCA1 CLCA2	2.15e-04	3	159	2	IPR004727
Domain	CLCA	CLCA1 CLCA2	2.15e-04	3	159	2	IPR013642
Domain	CLCA	CLCA1 CLCA2	2.15e-04	3	159	2	PF08434
Domain	Cadherin_2	PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5	2.30e-04	65	159	5	PF08266
Domain	Cadherin_N	PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5	2.30e-04	65	159	5	IPR013164
Domain	Cadherin_tail	PCDHGC5 PCDHA11 PCDHA7 PCDHA5	2.68e-04	37	159	4	PF15974
Domain	Cadherin_CBD	PCDHGC5 PCDHA11 PCDHA7 PCDHA5	2.68e-04	37	159	4	IPR031904
Domain	fn3	NPHS1 FNDC5 OBSL1 CMYA5 TYRO3 EPHA3 EPHA5	4.80e-04	162	159	7	PF00041
Domain	-	NPHS1 FCRL2 NRG1 COL6A3 FNDC5 OBSL1 SEMA3G CMYA5 TYRO3 CD86 CAMTA1 UNC5D PLXNB3 EPHA3 EPHA5	5.52e-04	663	159	15	2.60.40.10
Domain	Ig-like_fold	NPHS1 FCRL2 NRG1 COL6A3 FNDC5 OBSL1 SEMA3G CMYA5 TYRO3 CD86 CAMTA1 UNC5D PLXNB3 EPHA3 EPHA5	1.04e-03	706	159	15	IPR013783
Domain	GAT_dom	GGA2 TOM1L1	1.06e-03	6	159	2	IPR004152
Domain	-	GGA2 TOM1L1	1.06e-03	6	159	2	1.20.58.160
Domain	GAT	GGA2 TOM1L1	1.06e-03	6	159	2	PS50909
Domain	GAT	GGA2 TOM1L1	1.06e-03	6	159	2	PF03127
Domain	Ephrin_rec_like	TG EPHA3 EPHA5	1.21e-03	25	159	3	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	TG EPHA3 EPHA5	1.21e-03	25	159	3	IPR011641
Domain	HormR	CELSR1 CELSR3 CELSR2	1.21e-03	25	159	3	SM00008
Domain	ig	NPHS1 FCRL2 NRG1 OBSL1 SEMA3G TYRO3 UNC5D	1.23e-03	190	159	7	PF00047
Domain	Immunoglobulin	NPHS1 FCRL2 NRG1 OBSL1 SEMA3G TYRO3 UNC5D	1.23e-03	190	159	7	IPR013151
Domain	Vinculin/catenin	TLN2 VCL	1.47e-03	7	159	2	IPR006077
Domain	HRM	CELSR1 CELSR3 CELSR2	1.70e-03	28	159	3	PF02793
Domain	EGF_2	NRG1 FAT4 ITGB7 CELSR1 CELSR3 CELSR2 EPHA3 EPHA5	1.99e-03	265	159	8	PS01186
Domain	EGF_LAM_2	CELSR1 CELSR3 CELSR2	2.08e-03	30	159	3	PS50027
Domain	EGF_LAM_1	CELSR1 CELSR3 CELSR2	2.08e-03	30	159	3	PS01248
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MTA2 ENGASE PRKD2 MAN2A2 SREBF1 CLASP2 MLLT10 MLXIP PTCH1 FAM83H C2CD2L PLCD3 CELSR1 PNPLA6 CELSR3 CELSR2 SBF1 MCM3AP CSPG4 SCN8A TLN2 PUM1 PPP1R16A	3.00e-09	1105	165	23	35748872
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2	4.69e-09	80	165	8	10716726
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZHX3 WASHC2C ATG13 OBSL1 R3HDM2 MLXIP C2CD2L KLHL29 MCM3AP CIPC YY1AP1 CAMTA1 PUM1 PLXNB3	1.05e-08	407	165	14	12693553
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGC5 PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR3 CELSR2	5.41e-08	72	165	7	10380929
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MTA2 PRKD2 PRPF31 DDX52 DUOX2 CLASP2 APOB CMYA5 MDH2 ATAD2 PBRM1 NUDT4 ADSS2 AP2A2 CLCA2 NUP210 TLN2 ALDH2 COASY PUM1 DHX29 NUP153 RBM34 VCL	7.47e-08	1425	165	24	30948266
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5 CELSR1 CELSR2	8.66e-08	77	165	7	10835267
Pubmed	The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.	CELSR1 CELSR3 CELSR2	1.05e-07	3	165	3	11677057
Pubmed	The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.	CELSR1 CELSR3 CELSR2	4.18e-07	4	165	3	37224017
Pubmed	Developmental expression profiles of Celsr (Flamingo) genes in the mouse.	CELSR1 CELSR3 CELSR2	4.18e-07	4	165	3	11850187
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	CUX2 MLLT10 PTCH1 ZNF804A MAP3K1 NFE2L2 BUB1 ATF7IP2 CAMTA1 SAP130 PRRC1 NUP153	1.13e-06	430	165	12	35044719
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ZHX3 DMXL2 CUX2 OBSL1 C2CD2L AP2A2 TLN2 AKAP11 CAMTA1	1.41e-06	225	165	9	12168954
Pubmed	Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex.	FAT4 MPDZ DCHS1	2.08e-06	6	165	3	19506035
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 ANK2 MYO5A OBSL1 MPDZ CLASP2 MDH2 DMXL1 GTF2A1 OXA1L PNPLA6 TMTC3 SBF1 NUP210 BUB1B AKAP11 ALDH2 COASY USP48 DHX29 RBM34 VCL	2.35e-06	1487	165	22	33957083
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	ZHX3 NRG1 CUX2 CHAT PTCH1 CELSR3 CELSR2 UNC5D EPHA5	3.46e-06	251	165	9	29031500
Pubmed	Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.	CELSR1 CELSR3 CELSR2	3.62e-06	7	165	3	17937400
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	COL6A3 PANX2 CELSR1 SBF1 NUP210 CAMTA1 EIF2AK1	5.53e-06	142	165	7	19851296
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	PRPF31 TCTN3 COL6A3 GGA2 WASHC2C ANK2 TOM1L1 C15orf40 DDI2 TACC2 SEMA3G DMXL1 FAM83H SLC6A9 NUDT4 PUM1 DNASE1L1 UNC5D PPP1R16A	5.57e-06	1215	165	19	15146197
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	COL6A3 PANX2 CELSR1 SBF1 NUP210 CAMTA1 EIF2AK1	5.79e-06	143	165	7	20198315
Pubmed	Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.	SREBF1 MPDZ TFDP2 BUB1 BUB1B UNC5D	6.38e-06	95	165	6	21440680
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	PTCH1 CELSR1 CELSR3 CELSR2	6.73e-06	26	165	4	37228654
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DMXL2 ADNP2 MLXIP AP2A2 NUP210 CAMTA1	8.58e-06	100	165	6	10048485
Pubmed	Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.	FAT4 CELSR1 DCHS1	8.63e-06	9	165	3	28705793
Pubmed	Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.	PCDHGC5 PCDHA11 PCDHA5	8.63e-06	9	165	3	12154121
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGC5 PCDHA11 PCDHA7 PCDHA5	9.15e-06	28	165	4	15347688
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	MBNL1 FAM83H PNPLA6 TMTC3 DCP1B MCM3AP NUP210 ALDH2 PUM1 SAP130 NUP153	1.28e-05	457	165	11	32344865
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	CELSR1 CELSR3 CELSR2	1.68e-05	11	165	3	25024228
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA11 PCDHA7 PCDHA5	1.68e-05	11	165	3	9655502
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	FAT4 CELSR1 CELSR3 CELSR2 DCHS1	1.72e-05	67	165	5	21875946
Pubmed	Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.	CELSR1 CELSR3 CELSR2	2.24e-05	12	165	3	11891983
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA11 PCDHA7 PCDHA5	2.24e-05	12	165	3	10612399
Pubmed	Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.	CELSR1 CELSR3 CELSR2	2.24e-05	12	165	3	20631168
Pubmed	Dimethyl fumarate reduces oxidative stress, inflammation and fat deposition by modulation of Nrf2, SREBP-1c and NF-κB signaling in HFD fed mice.	SREBF1 NFE2L2	2.24e-05	2	165	2	34332979
Pubmed	Neuron/Glial Antigen 2-Type VI Collagen Interactions During Murine Temporomandibular Joint Osteoarthritis.	COL6A3 CSPG4	2.24e-05	2	165	2	30635602
Pubmed	Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells.	BUB1 BUB1B	2.24e-05	2	165	2	11792804
Pubmed	Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus.	CLCA1 MUC5AC	2.24e-05	2	165	2	16936271
Pubmed	Integrin-mediated cell adhesion: the cytoskeletal connection.	TLN2 VCL	2.24e-05	2	165	2	10320934
Pubmed	Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells.	CLCA1 MUC5AC	2.24e-05	2	165	2	16465045
Pubmed	Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9.	CELSR3 CELSR2	2.24e-05	2	165	2	10790539
Pubmed	Colostrum and mature breast milk analysis of serum irisin and sterol regulatory element-binding proteins-1c in gestational diabetes mellitus.	FNDC5 SREBF1	2.24e-05	2	165	2	29609490
Pubmed	Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.	TLN2 VCL	2.24e-05	2	165	2	32657269
Pubmed	Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking.	CELSR1 CELSR2	2.24e-05	2	165	2	23292348
Pubmed	Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease.	SREBF1 APOB	2.24e-05	2	165	2	12752570
Pubmed	Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury.	SREBF1 NFE2L2	2.24e-05	2	165	2	18395094
Pubmed	Mutations of mitotic checkpoint genes in human cancers.	BUB1 BUB1B	2.24e-05	2	165	2	9521327
Pubmed	Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer.	BUB1 BUB1B	2.24e-05	2	165	2	39048649
Pubmed	Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.	FAT4 DCHS1	2.24e-05	2	165	2	25355906
Pubmed	NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.	NRG1 NFE2L2	2.24e-05	2	165	2	29901070
Pubmed	Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels.	APOB INSIG2	2.24e-05	2	165	2	20858904
Pubmed	Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma.	PTCH1 ATAD2	2.24e-05	2	165	2	24805933
Pubmed	Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease.	SREBF1 NFE2L2	2.24e-05	2	165	2	28796629
Pubmed	Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.	BUB1 BUB1B	2.24e-05	2	165	2	11782350
Pubmed	BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling.	BUB1 BUB1B	2.24e-05	2	165	2	35767360
Pubmed	The protease DDI2 regulates NRF1 activation in response to cadmium toxicity.	DDI2 NFE2L2	2.24e-05	2	165	2	36248746
Pubmed	Regulation of neutrophil elastase-induced MUC5AC expression by nuclear factor erythroid-2 related factor 2 in human airway epithelial cells.	NFE2L2 MUC5AC	2.24e-05	2	165	2	20216230
Pubmed	The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner.	BUB1 BUB1B	2.24e-05	2	165	2	9889005
Pubmed	[Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis].	CLCA1 MUC5AC	2.24e-05	2	165	2	20464982
Pubmed	BUB1 and BUBR1 inhibition decreases proliferation and colony formation, and enhances radiation sensitivity in pediatric glioblastoma cells.	BUB1 BUB1B	2.24e-05	2	165	2	23728478
Pubmed	Structure of the planar cell polarity cadherins Fat4 and Dachsous1.	FAT4 DCHS1	2.24e-05	2	165	2	36797229
Pubmed	Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture.	FAT4 DCHS1	2.24e-05	2	165	2	25930014
Pubmed	Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1.	BUB1 BUB1B	2.24e-05	2	165	2	28287092
Pubmed	A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.	BUB1 BUB1B	2.24e-05	2	165	2	25611342
Pubmed	Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.	CLCA1 CLCA2	2.24e-05	2	165	2	23112050
Pubmed	Dependence of cell survival on correlative activities of xanthine oxidase and dihydopyrimidine dehydrogenase in human brain-derived cell culture.	DPYD XDH	2.24e-05	2	165	2	23597150
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGC5 PCDH11Y PCDHA11 PCDHA7 PCDHA5	2.80e-05	74	165	5	10817752
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	PTCH1 SIX3 STK39 UNC5D PLXNB3 EPHA5	3.20e-05	126	165	6	16284245
Pubmed	Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.	CELSR1 CELSR3 CELSR2	3.67e-05	14	165	3	39225402
Pubmed	A role for the EphA family in the topographic targeting of vomeronasal axons.	VN1R17P EPHA3 EPHA5	3.67e-05	14	165	3	11222144
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	PRPF31 COL6A3 FAT4 CPA5 PCDHGC5 APOB EMSY CELSR3 TTC21B DSG4 ZMYM4	3.70e-05	513	165	11	25798074
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA11 PCDHA7 PCDHA5	4.58e-05	15	165	3	15640798
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	CELSR1 CELSR3 CELSR2	4.58e-05	15	165	3	20473291
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MTA2 PRPF31 WASHC2C DDX52 ATAD2 THOC6 PBRM1 PNPLA6 JRK NUP210 PUM1 ZMYM4 NUP153 RBM34	5.64e-05	847	165	14	35850772
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MTA2 TCTN3 FAT4 MAN2A2 SREBF1 DMXL1 PLA2R1 CELSR1 NUDT4 CELSR3 TMTC3 CELSR2 MRC2 CSPG4 NUP210 USP48 DNASE1L1	6.18e-05	1201	165	17	35696571
Pubmed	CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting.	SREBF1 INSIG2	6.69e-05	3	165	2	29679236
Pubmed	The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes.	BUB1 BUB1B	6.69e-05	3	165	2	15611331
Pubmed	Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling.	FNDC5 NFE2L2	6.69e-05	3	165	2	36940733
Pubmed	Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.	CLCA1 CLCA2	6.69e-05	3	165	2	19210762
Pubmed	Identification of ocular regulatory functions of core histone variant H3.2.	EPHA3 EPHA5	6.69e-05	3	165	2	36529279
Pubmed	Characterization of the tetratricopeptide-containing domain of BUB1, BUBR1, and PP5 proves that domain amphiphilicity over amino acid sequence specificity governs protein adsorption and interfacial activity.	BUB1 BUB1B	6.69e-05	3	165	2	18547097
Pubmed	Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma.	BUB1 BUB1B	6.69e-05	3	165	2	33872216
Pubmed	Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes.	MYO5A KCNA5	6.69e-05	3	165	2	24508725
Pubmed	Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction.	BUB1 BUB1B	6.69e-05	3	165	2	22331848
Pubmed	P. aeruginosa lipopolysaccharide-induced MUC5AC and CLCA3 expression is partly through Duox1 in vitro and in vivo.	CLCA1 MUC5AC	6.69e-05	3	165	2	23691121
Pubmed	Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.	BUB1 BUB1B	6.69e-05	3	165	2	14646599
Pubmed	Genotypes and phenotypes of congenital goitre and hypothyroidism caused by mutations in dual oxidase 2 genes.	DUOX2 TG	6.69e-05	3	165	2	24735383
Pubmed	Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.	BUB1 BUB1B	6.69e-05	3	165	2	17227893
Pubmed	CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption.	CUX2 ALDH2	6.69e-05	3	165	2	33093602
Pubmed	The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis.	CLCA1 CLCA2	6.69e-05	3	165	2	14512419
Pubmed	The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2.	MPDZ CSPG4	6.69e-05	3	165	2	10967549
Pubmed	An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system.	TYRO3 EPHA3	6.69e-05	3	165	2	2025425
Pubmed	Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells.	XDH NFE2L2	6.69e-05	3	165	2	29414774
Pubmed	Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.	CLCA1 CLCA2	6.69e-05	3	165	2	10437792
Pubmed	Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortex.	CHAT SIX3	6.69e-05	3	165	2	24027290
Pubmed	brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain.	TYRO3 EPHA3	6.69e-05	3	165	2	8108111
Pubmed	BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.	BUB1 BUB1B	6.69e-05	3	165	2	28943088
Pubmed	BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer.	BUB1 BUB1B	6.69e-05	3	165	2	35493295
Pubmed	EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.	EPHA3 EPHA5	6.69e-05	3	165	2	24117969
Pubmed	The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis.	BUB1 BUB1B	6.69e-05	3	165	2	9914370
Pubmed	Vinculin and talin: focus on the myocardium.	TLN2 VCL	6.69e-05	3	165	2	19952892
Pubmed	Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively.	TG NFE2L2	6.69e-05	3	165	2	31421134
Pubmed	Whole-Retina Reduced Electrophysiological Activity in Mice Bearing Retina-Specific Deletion of Vesicular Acetylcholine Transporter.	CHAT SIX3	6.69e-05	3	165	2	26226617
Interaction	DCANP1 interactions	FAT4 CELSR1 CELSR3 CELSR2 DCHS1	3.15e-07	19	160	5	int:DCANP1
Interaction	NUP210P1 interactions	FAT4 CELSR1 CELSR3 CELSR2 DCHS1 STK39	9.44e-07	42	160	6	int:NUP210P1
Interaction	LOC254896 interactions	FAT4 CELSR1 CELSR2 CSPG4 DCHS1 USP48	1.09e-06	43	160	6	int:LOC254896
Interaction	XAGE1A interactions	FAT4 CELSR1 CELSR3 CELSR2 DCHS1	1.76e-05	41	160	5	int:XAGE1A
Interaction	PCDHGB1 interactions	FAT4 C2CD2L CELSR1 CELSR3 CELSR2 DCHS1	3.39e-05	77	160	6	int:PCDHGB1
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3 CELSR2	2.51e-07	3	115	3	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3 CELSR2	2.51e-07	3	115	3	1189
GeneFamily	Fibronectin type III domain containing	NPHS1 FNDC5 CMYA5 TYRO3 ATF7IP2 EPHA3 EPHA5	7.34e-05	160	115	7	555
GeneFamily	Cadherin related	FAT4 DCHS1 CDHR4	1.60e-04	17	115	3	24
GeneFamily	Chloride channel accessory	CLCA1 CLCA2	2.39e-04	4	115	2	867
GeneFamily	Clustered protocadherins	PCDHGC5 PCDHA11 PCDHA7 PCDHA5	7.35e-04	64	115	4	20
GeneFamily	Immunoglobulin like domain containing	NPHS1 FCRL2 OBSL1 SEMA3G TYRO3 CD86	1.47e-03	193	115	6	594
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA3 EPHA5	3.47e-03	14	115	2	1095
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZHX3 ADNP2	3.99e-03	15	115	2	529
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000	PRKD2 ZHX3 RELCH FAT4 CUX2 PCDHA11 CLASP2 PTCH1 PCMTD1 KLHL29 CELSR1 HEATR6 CLCA1 CLCA2 MRC2 TLN2 CAMTA1 VCL EPHA3 CDHR4 EPHA5	5.44e-07	806	157	21	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 COL6A3 ZNF804A TYRO3 PLA2R1 MRC2 ATF7IP2 EPHA3	4.26e-07	184	164	8	1c857126c0ea0671f0d60b048efca288d348d653
ToppCell	Influenza_Severe-RBC\|World / Disease group and Cell class	SLC6A19 DDI2 SLC6A9 NUDT4 MRC2 TLN2 EIF2AK1 TNS1	5.01e-07	188	164	8	f0438e6a77ee1f0456cb65926685266fff470983
ToppCell	mild_COVID-19_(asymptomatic)-cDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	NPHS1 TCTN3 ACY3 PANX2 ITGB7 CD86 ALDH2	3.68e-06	173	164	7	71dc0051c87b84e3cf13cde8858166f2a474b5dc
ToppCell	severe_influenza-RBC\|World / disease group, cell group and cell class (v2)	SLC6A19 SLC6A9 NUDT4 MRC2 TLN2 EIF2AK1 TNS1	6.15e-06	187	164	7	f846750575f318503d21ade30f5bfd2e1d4c84af
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DDI2 TFDP2 SLC6A9 NUDT4 TLN2 EIF2AK1 TNS1	7.55e-06	193	164	7	305e15ee467826ee08b2617c69f250ad39c11b19
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DDI2 TFDP2 SLC6A9 NUDT4 TLN2 EIF2AK1 TNS1	7.55e-06	193	164	7	dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 ACY3 SLC6A19 SLC34A3 SLC13A1 ALDH2 PPP1R16A	8.92e-06	198	164	7	a9d72b17adfddb6ac1857c5f094280e86582693b
ToppCell	myeloid-cDC\|myeloid / Lineage and Cell class	TCTN3 MDH2 ITGB7 OXA1L CD86 ALDH2 PPP1R16A	8.92e-06	198	164	7	a751cc63bc6314f57fef4cd2a36a84b23b379fa0
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 ACY3 SLC6A19 SLC34A3 SLC13A1 ALDH2 PPP1R16A	8.92e-06	198	164	7	b933bd66f544822fcf1f2aa2d928c31500e2b3f4
ToppCell	Influenza-Influenza_Severe-Others-RBC\|Influenza_Severe / Disease, condition lineage and cell class	DDI2 SLC6A9 NUDT4 MRC2 TLN2 EIF2AK1 TNS1	9.22e-06	199	164	7	da0fec0a492bc3827d9066d2590bcd466cd45564
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	GGA2 DDX52 ATAD2 THOC6 DCP1B BUB1B VCL	9.53e-06	200	164	7	691b3edf7d8449556e8bf611662eb85772959f0f
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	GGA2 DDX52 ATAD2 THOC6 DCP1B BUB1B VCL	9.53e-06	200	164	7	36a110aa91a791fdf1142e7869e8aa0d342402d0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	GGA2 DDX52 ATAD2 THOC6 DCP1B BUB1B VCL	9.53e-06	200	164	7	4e077aa7faddcebdfc54667f8b3990704441005b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	GGA2 DDX52 ATAD2 THOC6 DCP1B BUB1B VCL	9.53e-06	200	164	7	d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4-_Ptgds_(Bmp4)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PTX4 BSPRY SLC6A19 USP9Y ITGB7	1.03e-05	78	164	5	87ed71a692416a21c8c11b5adbfe629f7d57ddb4
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4-_Ptgds_(Bmp4)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PTX4 BSPRY SLC6A19 USP9Y ITGB7	1.03e-05	78	164	5	9545ae56fda3893b82b5efa82082e1f585a5f92a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 DUOX2 ZNF804A KLHL29 TYRO3 PLA2R1	2.39e-05	155	164	6	90e629681a72baacc7981b82883866a487638dbc
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5A TLR7 CELSR1 CLCA1 CLCA2 CD86	2.39e-05	155	164	6	0e24e767a3895d31d34cabeaca0354aadae34e44
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5A TLR7 CELSR1 CLCA1 CLCA2 CD86	2.39e-05	155	164	6	f3489a548a2c0cc2d9117ff85865c6089ea0835d
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MS4A18 DUOX2 USP9Y BUB1 UNC5D EPHA5	3.06e-05	162	164	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACY3 DUOX2 CLCA1 NUDT4 CLCA2 CDHR4	3.39e-05	165	164	6	50a8513d8d2630861499393a7f102b35366bad37
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	3.75e-05	168	164	6	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	367C-Fibroblasts-Fibroblast-G\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 PCDH11Y APOB CMYA5 PTCH1 SLC6A9	3.75e-05	168	164	6	8c95093b1ea45826f62893edd3c410fe53b563a4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	3.75e-05	168	164	6	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	367C-Fibroblasts-Fibroblast-G-\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 PCDH11Y APOB CMYA5 PTCH1 SLC6A9	3.75e-05	168	164	6	b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	3.75e-05	168	164	6	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	DMXL2 MYO5A CMYA5 TG CD86 PPP1R1C	4.01e-05	170	164	6	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	10x3'2.3-week_14-16-Myeloid_DC-DC-DC_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PTX4 ACY3 MDH2 ITGB7 CELSR3 ALDH2	4.42e-05	173	164	6	a361474ad6f058bb3d3f9671bae697205535090b
ToppCell	COVID-19-kidney-Podocyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NPHS1 ZNF804A KLHL29 TYRO3 PLA2R1 UNC5D	4.71e-05	175	164	6	a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 SEMA3G ZNF804A KLHL29 TYRO3 PLA2R1	5.02e-05	177	164	6	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 SEMA3G ZNF804A KLHL29 TYRO3 PLA2R1	5.18e-05	178	164	6	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	5.34e-05	179	164	6	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	PCW_10-12-Neuronal-Neuronal_postreplicative\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ANK2 ZNF804A CELSR2 PPP1R1C PLXNB3 EPHA5	5.68e-05	181	164	6	1aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCell	PCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ANK2 ZNF804A CELSR2 PPP1R1C PLXNB3 EPHA5	5.68e-05	181	164	6	6aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCell	PCW_10-12-Neuronal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ANK2 ZNF804A CELSR2 PPP1R1C PLXNB3 EPHA5	5.68e-05	181	164	6	381b553e2cae65ce6be100662a5f9f963353840c
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLM BSPRY FNDC5 SLC6A9 HEATR6 BUB1B	5.68e-05	181	164	6	3fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-2\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SREBF1 TLR7 ATF7IP2 ZNF620 EME2 SAP130	5.68e-05	181	164	6	75035a3211e524bb659b82e6979f7d3a3121ae70
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	5.68e-05	181	164	6	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	5.68e-05	181	164	6	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Tshz2_(Deep_layer_pyramidal_cells--layer_5)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ARL9 USP9Y CLCA2 PPP1R1C	5.78e-05	57	164	4	d80eb5ade3c90344b67811e7f313c7d0720715f0
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	NPHS1 SEMA3G ZNF804A KLHL29 TYRO3 PLA2R1	6.04e-05	183	164	6	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD SREBF1 PM20D1 DDI2 FAM83H IGFALS	6.04e-05	183	164	6	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	6.04e-05	183	164	6	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCH1 SLC6A9 CLCA1 PNPLA6 CLCA2 COASY	6.04e-05	183	164	6	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA3 SLC6A19 APOB SLC34A3 SLC13A1 TLN2	6.41e-05	185	164	6	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	6.41e-05	185	164	6	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA3 SLC6A19 APOB SLC34A3 SLC13A1 TLN2	6.41e-05	185	164	6	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 CMYA5 ZNF804A KLHL29 TYRO3 PLA2R1	6.41e-05	185	164	6	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 COL27A1 KLHL29 CELSR1 SLC13A1 UNC5D	6.80e-05	187	164	6	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	5'-Adult-Appendix-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUDT4 KCNA5 CSPG4 TNS1 VCL EPHA3	7.22e-05	189	164	6	0daa8efac08dca9525d2b8d421952068cab4eb50
ToppCell	5'-Adult-Appendix-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUDT4 KCNA5 CSPG4 TNS1 VCL EPHA3	7.22e-05	189	164	6	b6bb4327b4560d07d2b728abcc5f144f428948a5
ToppCell	Control-Myeloid\|Control / group, cell type (main and fine annotations)	DMXL2 MYO5A ZNF804A TG PNPLA6 CD86	7.65e-05	191	164	6	9c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell	10x3'2.3-week_17-19-Myeloid_DC-DC-pDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CUX2 ACY3 TLR7 ITGB7 KCNA5 ALDH2	7.65e-05	191	164	6	faf4de97003a938a243b0101456913c2b0e1804f
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	DPYD DMXL2 MYO5A AP2A2 CD86 BUB1B	7.87e-05	192	164	6	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 SEMA3G ZNF804A KLHL29 TYRO3 PLA2R1	7.87e-05	192	164	6	ef0aba777072429a6ab7dcfcc305673975946580
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A3 FAT4 ANK2 MRC2 TLN2 EPHA3	7.87e-05	192	164	6	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	Influenza_Severe-RBC\|Influenza_Severe / Disease group and Cell class	DDI2 SLC6A9 NUDT4 MRC2 EIF2AK1 TNS1	7.87e-05	192	164	6	f19b6da3fd98da1a76d2570137a8f73a3850ebcb
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	COL6A3 FAT4 ANK2 MRC2 TLN2 EPHA3	7.87e-05	192	164	6	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 SEMA3G ZNF804A KLHL29 TYRO3 PLA2R1	8.10e-05	193	164	6	3eaa0461618582a1754400624350d269d24e750a
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	DPYD DMXL2 MYO5A AP2A2 CD86 BUB1B	8.10e-05	193	164	6	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	RA-08._Macrophage\|World / Chamber and Cluster_Paper	DPYD DMXL2 MYO5A TG AP2A2 CD86	8.10e-05	193	164	6	5fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	CUX2 COL27A1 TOM1L1 ATAD2 SCN8A ATF7IP2	8.10e-05	193	164	6	503a979328c68b096680b71359a26f02fafdff35
ToppCell	kidney_cells-CKD+DKD_normotensive\|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 ACY3 SLC6A19 SLC34A3 ALDH2 PPP1R16A	8.10e-05	193	164	6	522a301bb48a5c40def7e0b58b2a2c13d85ac7a1
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	DPYD DMXL2 MYO5A TG AP2A2 CD86	8.33e-05	194	164	6	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	facs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAT TACC2 KLHL29 NUDT4 CSPG4 TNS1	8.82e-05	196	164	6	90edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAT TACC2 KLHL29 NUDT4 CSPG4 TNS1	8.82e-05	196	164	6	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	SALL3 COL27A1 CELSR1 NFE2L2 MRC2 NUP210	9.06e-05	197	164	6	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	SALL3 COL27A1 CELSR1 NFE2L2 MRC2 NUP210	9.06e-05	197	164	6	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTA2 MBNL1 CLASP2 MAP3K1 PBRM1 VCL	9.32e-05	198	164	6	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 SREBF1 TYRO3 SLC6A9 SBF1 PLXNB3	9.32e-05	198	164	6	43a2ce64fa309bac89a44ea320e87ae2cc39f782
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	COL6A3 ANK2 COL27A1 PTCH1 MRC2 TNS1	9.32e-05	198	164	6	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTA2 MBNL1 CLASP2 MAP3K1 CELSR1 VCL	9.32e-05	198	164	6	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTA2 MBNL1 CLASP2 MAP3K1 PBRM1 VCL	9.32e-05	198	164	6	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTA2 MBNL1 CLASP2 MAP3K1 PBRM1 VCL	9.58e-05	199	164	6	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 SLC6A19 SLC34A3 SLC13A1 ALDH2 PPP1R16A	9.58e-05	199	164	6	4bde35e5df019189433d65d415e29a0c1145ac66
ToppCell	10x5'v1-week_14-16-Hematopoietic-erythroid-mid_erythroid\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TFDP2 SLC6A9 NUDT4 MRC2 EIF2AK1 TNS1	9.58e-05	199	164	6	e6853b2c0ef6549d5554754c5d5f65825b66025b
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_only / Treatment groups by lineage, cell group, cell type	TACC2 TYRO3 SLC6A9 KCNA5 CSPG4 VCL	9.85e-05	200	164	6	7c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPHS1 FNDC5 BUB1B EME2 EPHA5	1.38e-04	134	164	5	64979e1a056b7406e1be39c5ebe2f8d731ac3c17
Drug	Tinidazole [19387-91-8]; Down 200; 16.2uM; PC3; HT_HG-U133A	MTA2 FAT4 GGA2 POLM ATG13 EMSY AP2A2 MRC2 ATF7IP2 TNS1	1.32e-06	196	160	10	4548_DN
Drug	Ethaverine hydrochloride [985-13-7]; Down 200; 9.2uM; PC3; HT_HG-U133A	ABCA3 GGA2 BSPRY PCDHA5 MLLT10 TFDP2 GTF2A1 SBF1 TMEM70 TNS1	1.38e-06	197	160	10	6737_DN
Drug	Guanabenz acetate [23256-50-0]; Up 200; 13.8uM; PC3; HT_HG-U133A	GGA2 POLM APOB MLLT10 C2CD2L ART1 AP2A2 NUP210 TNS1	9.79e-06	194	160	9	4642_UP
Drug	S-(+)-ibuprofen [51146-56-6]; Up 200; 19.4uM; PC3; HT_HG-U133A	NRG1 ANK2 DUOX2 PCDHA5 APOB PTCH1 C2CD2L TLN2 EPHA3	9.79e-06	194	160	9	6712_UP
Drug	PF-00539758-00 [351321-34-1]; Down 200; 10uM; PC3; HT_HG-U133A	TUT1 SIX3 CELSR2 AP2A2 TMEM70 NUP210 ATF7IP2 USP48 TNS1	1.15e-05	198	160	9	6421_DN
Drug	Deferoxamine mesylate [138-14-7]; Up 200; 6uM; PC3; HT_HG-U133A	ANK2 DUOX2 PCDHA5 TUT1 MAP3K1 HEATR6 AP2A2 TNS1 VCL	1.25e-05	200	160	9	3760_UP
Disease	Van Maldergem Wetzburger Verloes syndrome	FAT4 DCHS1	3.00e-05	2	162	2	C1832390
Disease	Van Maldergem syndrome	FAT4 DCHS1	3.00e-05	2	162	2	cv:C1832390
Disease	Periventricular gray matter heterotopia	FAT4 DCHS1	3.00e-05	2	162	2	C1849173
Disease	coronary artery disease	PRKD2 ZHX3 COL6A3 DPYD FAT4 CUX2 SREBF1 DUOX2 R3HDM2 APOB MAP3K1 DMXL1 CELSR2 NUP210 ALDH2 USP48 TNS1 SAP130 DNASE1L1	3.25e-05	1194	162	19	EFO_0001645
Disease	Colorectal Carcinoma	DPYD RELCH ABCA3 SALL3 ANK2 APOB ZNF804A MCM3AP BUB1 BUB1B DCHS1 ALDH2 ZMYM4 EPHA3	3.55e-05	702	162	14	C0009402
Disease	Heterotopia, Periventricular, Autosomal Recessive	FAT4 DCHS1	8.95e-05	3	162	2	C1842563
Disease	metabolic syndrome	CUX2 APOB MLLT10 TYRO3 CELSR2 ALDH2 COASY	1.24e-04	200	162	7	EFO_0000195
Disease	pulse pressure measurement	NRG1 COL6A3 CUX2 ANK2 COL27A1 MBNL1 PCDHA11 DDI2 PCDHA7 PCDHA5 KLHL29 PLCD3 PBRM1 NFE2L2 MRC2 PPP1R1C TLN2 COASY VCL	2.41e-04	1392	162	19	EFO_0005763
Disease	epilepsy (implicated_via_orthology)	ANK2 KCNA5 TMTC3 SBF1 SLC13A1 SCN8A	2.91e-04	163	162	6	DOID:1826 (implicated_via_orthology)
Disease	Warburton Anyane Yeboa syndrome	BUB1 BUB1B	2.96e-04	5	162	2	C2931286
Disease	Mosaic variegated aneuploidy syndrome 1	BUB1 BUB1B	2.96e-04	5	162	2	C1850343
Disease	serum alanine aminotransferase measurement	CUX2 COL27A1 MBNL1 XDH APOB MLXIP CMYA5 PTCH1 MAP3K1 CELSR2 SLC13A1 NUP210 USP48 PPP1R16A	3.29e-04	869	162	14	EFO_0004735
Disease	chronotype measurement	NRG1 DPYD ANK2 DDI2 R3HDM2 ZNF804A KLHL29 SCN8A DCHS1 CAMTA1 USP48 UNC5D PRRC1 EPHA5	3.81e-04	882	162	14	EFO_0008328
Disease	Thyroid Dyshormonogenesis 1	DUOX2 TG	4.43e-04	6	162	2	C1848805
Disease	BMI-adjusted waist-hip ratio, forced expiratory volume	CUX2 ALDH2	4.43e-04	6	162	2	EFO_0004314, EFO_0007788
Disease	peptic ulcer disease, schizophrenia	DPYD JRK	4.43e-04	6	162	2	MONDO_0004247, MONDO_0005090
Disease	1,5 anhydroglucitol measurement	PCDHA11 PCDHA7 PCDHA5	5.34e-04	29	162	3	EFO_0008009
Disease	Non-alcoholic Fatty Liver Disease	SREBF1 NFE2L2 ALDH2 EIF2AK1	6.06e-04	70	162	4	C0400966
Disease	Nonalcoholic Steatohepatitis	SREBF1 NFE2L2 ALDH2 EIF2AK1	6.06e-04	70	162	4	C3241937
Disease	LDL cholesterol change measurement	APOB CELSR2	6.18e-04	7	162	2	EFO_0007804
Disease	extracellular sulfatase Sulf-2 measurement	NRG1 R3HDM2	6.18e-04	7	162	2	EFO_0801596
Disease	Goiter	DUOX2 TG	6.18e-04	7	162	2	C0018021
Disease	gallbladder cancer (is_marker_for)	DPYD BUB1B	6.18e-04	7	162	2	DOID:3121 (is_marker_for)
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	APOB CELSR2	8.21e-04	8	162	2	EFO_0008589, EFO_0008595
Disease	holoprosencephaly (is_implicated_in)	PTCH1 SIX3	8.21e-04	8	162	2	DOID:4621 (is_implicated_in)
Disease	common bile duct neoplasm (is_marker_for)	APOB MUC5AC	8.21e-04	8	162	2	DOID:4608 (is_marker_for)
Disease	brain measurement, neuroimaging measurement	ZHX3 PM20D1 MLLT10 PTCH1 MAP3K1 TG PBRM1 KCNA5 TNS1 EPHA3	9.65e-04	550	162	10	EFO_0004346, EFO_0004464
Disease	C-reactive protein measurement	DPYD DMXL2 CUX2 DDX52 MBNL1 R3HDM2 APOB MLLT10 SIX3 MAP3K1 SLC6A9 CELSR2 NFE2L2 CAMTA1 EME2 EPHA3	1.02e-03	1206	162	16	EFO_0004458
Disease	BMI-adjusted waist circumference, forced expiratory volume	CUX2 ALDH2	1.05e-03	9	162	2	EFO_0004314, EFO_0007789
Disease	neuroimaging measurement, brain volume measurement	PM20D1 MLLT10 PTCH1 TFDP2 MAP3K1 PBRM1 EPHA3	1.06e-03	286	162	7	EFO_0004346, EFO_0006930
Disease	neuroticism measurement, cognitive function measurement	PM20D1 PCDHA11 PCDHA7 PCDHA5 R3HDM2 MLLT10 PTCH1 ZNF804A TG KLHL29	1.20e-03	566	162	10	EFO_0007660, EFO_0008354
Disease	cortical thickness	ZHX3 SREBF1 PM20D1 TACC2 MLLT10 PTCH1 TFDP2 MAP3K1 TG KLHL29 CELSR1 KCNA5 CAMTA1 TNS1 EPHA3	1.26e-03	1113	162	15	EFO_0004840
Disease	Holoprosencephaly sequence	PTCH1 SIX3	1.31e-03	10	162	2	cv:C0079541
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	DMXL2 PTCH1 ZNF804A TFDP2 SLC6A9 TTC21B CDHR4 PPP1R16A	1.66e-03	398	162	8	EFO_0003756, EFO_0003888, EFO_0004337
Disease	Squamous cell carcinoma of esophagus	FAT4 NFE2L2 BUB1B ALDH2	1.89e-03	95	162	4	C0279626
Disease	Pathological accumulation of air in tissues	ABCA3 NFE2L2	1.91e-03	12	162	2	C0013990
Disease	alcohol consumption measurement, alcohol drinking	CUX2 ALDH2	1.91e-03	12	162	2	EFO_0004329, EFO_0007878
Disease	Liver carcinoma	DPYD SREBF1 IGFALS CELSR3 NFE2L2 CSPG4 TMEM70 BUB1 BUB1B	2.03e-03	507	162	9	C2239176
Disease	chronic obstructive pulmonary disease (is_marker_for)	CLCA1 NFE2L2 CD86 MUC5AC	2.04e-03	97	162	4	DOID:3083 (is_marker_for)
Disease	Ischemic stroke	NRG1 COL6A3 ANK2 OR4E1 MPDZ MLXIP ALDH2	2.16e-03	324	162	7	HP_0002140
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	ZHX3 APOB CELSR2 INSIG2	2.20e-03	99	162	4	EFO_0004611, EFO_0007878
Disease	gamma-glutamylleucine measurement	CUX2 MBNL1	2.25e-03	13	162	2	EFO_0021140
Disease	Congenital Hypothyroidism	DUOX2 TG	2.25e-03	13	162	2	C0010308
Disease	hypothyroidism (implicated_via_orthology)	DUOX2 TG	2.25e-03	13	162	2	DOID:1459 (implicated_via_orthology)
Disease	pancreatic cancer (is_marker_for)	DPYD PTCH1 BUB1B MUC5AC	2.36e-03	101	162	4	DOID:1793 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	ZHX3 APOB CELSR2 INSIG2	2.45e-03	102	162	4	EFO_0004329, EFO_0004611
Disease	Malignant neoplasm of breast	NRG1 DPYD ABCA3 ANK2 XDH TACC2 PANX2 EMSY MAP3K1 GTF2A1 PBRM1 KCNA5 CLCA2 TNS1	2.48e-03	1074	162	14	C0006142
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX2 TG	2.61e-03	14	162	2	DOID:0050328 (implicated_via_orthology)
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	APOB CELSR2	2.61e-03	14	162	2	EFO_0004611, EFO_0008589
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	ZHX3 APOB CELSR2	2.79e-03	51	162	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	blood phosphate measurement	ZHX3 CUX2 SLC34A3 CD86 USP48	2.79e-03	174	162	5	EFO_0010972
Disease	Alobar Holoprosencephaly	PTCH1 SIX3	3.00e-03	15	162	2	C0431363
Disease	Hypertriglyceridemia	APOB CELSR2	3.00e-03	15	162	2	C0020557
Disease	response to statin, LDL cholesterol change measurement	APOB CELSR2	3.00e-03	15	162	2	EFO_0007804, GO_0036273
Disease	Rhabdomyosarcoma	PTCH1 BUB1B	3.00e-03	15	162	2	C0035412
Disease	nervous system disorder	DPYD PNPLA6 SCN8A	3.11e-03	53	162	3	C0027765
Disease	Peripheral Nervous System Diseases	DPYD MYO5A PNPLA6	3.28e-03	54	162	3	C4721453
Disease	myocardial infarction	ZHX3 COL6A3 CUX2 APOB CELSR2 ALDH2 TNS1	3.31e-03	350	162	7	EFO_0000612
Disease	coffee consumption measurement	PRKD2 CUX2 SREBF1 MDH2 ALDH2	3.39e-03	182	162	5	EFO_0006781
Disease	teratocarcinoma-derived growth factor 1 measurement	MYO5A TNS1	3.42e-03	16	162	2	EFO_0008297
Disease	Schizoaffective disorder-bipolar type	PTCH1 ZNF804A	3.42e-03	16	162	2	EFO_0009965
Disease	Lobar Holoprosencephaly	PTCH1 SIX3	3.42e-03	16	162	2	C0431362
Disease	Semilobar Holoprosencephaly	PTCH1 SIX3	3.42e-03	16	162	2	C0751617
Disease	gout, hyperuricemia	PRKD2 ALDH2	3.42e-03	16	162	2	EFO_0004274, EFO_0009104
Disease	creatinine measurement	NPHS1 PRKD2 NRG1 CUX2 SLC6A19 R3HDM2 SLC34A3 TFDP2 C2CD2L CELSR3 CELSR2 NFE2L2 CSPG4	3.45e-03	995	162	13	EFO_0004518
Disease	reaction time measurement	DPYD CUX2 ATG13 PM20D1 TACC2 SIX3 ALDH2 CAMTA1 PRRC1 PPP1R16A	3.56e-03	658	162	10	EFO_0008393
Disease	Holoprosencephaly	PTCH1 SIX3	3.86e-03	17	162	2	C0079541
Disease	response to radiation, Urinary retention	COL6A3 CAMTA1	3.86e-03	17	162	2	GO_0009314, HP_0000016
Disease	diabetic neuropathy (biomarker_via_orthology)	NRG1 SREBF1	3.86e-03	17	162	2	DOID:9743 (biomarker_via_orthology)
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	APOB CELSR2	3.86e-03	17	162	2	EFO_0022232
Disease	non-alcoholic steatohepatitis (biomarker_via_orthology)	SREBF1 NFE2L2	3.86e-03	17	162	2	DOID:0080547 (biomarker_via_orthology)
Disease	prostate carcinoma, type 2 diabetes mellitus	MBNL1 SREBF1 EMSY	4.22e-03	59	162	3	EFO_0001663, MONDO_0005148
Disease	asthma (biomarker_via_orthology)	CHAT CD86 MUC5AC	4.22e-03	59	162	3	DOID:2841 (biomarker_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	APOB CELSR2	4.33e-03	18	162	2	EFO_0008317, EFO_0008589
Disease	amino acid measurement	FAT4 TACC2 MLXIP KLHL29 PLA2R1 NUDT4 ATF7IP2 STK39 CAMTA1 UNC5D	4.39e-03	678	162	10	EFO_0005134
Disease	gout	PRKD2 CUX2 R3HDM2 MLXIP ALDH2	4.63e-03	196	162	5	EFO_0004274
Disease	sodium-coupled monocarboxylate transporter 1 measurement	APOB CELSR2	4.82e-03	19	162	2	EFO_0802076
Disease	chronic obstructive pulmonary disease	COL6A3 DPYD ABCA3 C15orf40 TUT1 PTCH1 EMSY MRC2 ALDH2 TNS1	4.85e-03	688	162	10	EFO_0000341
Disease	glucose measurement	ZHX3 CUX2 MBNL1 R3HDM2 SIX3 ALDH2 CDHR4	5.17e-03	380	162	7	EFO_0004468
Disease	hip bone mineral density	NRG1 PTCH1 KCNA5 TTC21B	5.22e-03	126	162	4	EFO_0007702
Disease	Familial aplasia of the vermis	TCTN3 TTC21B	5.33e-03	20	162	2	cv:C0431399

Protein segments in the cluster

Peptide	Gene	Start	Entry
VNQIIVNFPSFLPAF	TTC21B	201	Q7Z4L5
NTASLIAVPAVLPSF	BUB1B	326	O60566
FNPPVLVFVQSIERA	DDX52	411	Q9Y2R4
PINQVTLTSLDIPFA	ATG13	381	O75143
FDQISVPASLIQPGV	CAMTA1	906	Q9Y6Y1
LQRASFSAVPVLANP	ACY3	41	Q96HD9
VVPPLANAISAALVS	BUB1	361	O43683
LPPVFANFTQLLTIS	CSPG4	421	Q6UVK1
PVFAASSDQSQIPVI	EPHA5	561	P54756
VNVTVLDANDPPIFT	FAT4	3391	Q6V0I7
QLIAANPVLPLVVFA	ARL9	111	Q6T311
SIVVSNFPQPRSALQ	ABCA3	1071	Q99758
ALQNPSAVPRFVQAI	IGFALS	551	P35858
PNDPAIISNFSAAVV	AKAP11	866	Q9UKA4
AVQIPFFAKLTPNVT	DPYD	701	Q12882
LQNIPSFAPVLLLAT	ATAD2	881	Q6PL18
AASINPATDIPNVLV	DMXL2	361	Q8TDJ6
NEPIFVSSPFQATVL	CELSR1	561	Q9NYQ6
VSSPFQATVLENVPL	CELSR1	566	Q9NYQ6
NAPIFVSTPFQATVL	CELSR2	501	Q9HCU4
SVLANFSQPEIVPIS	CD86	131	P42081
ILSTQDQAAAFTLPP	DHX29	906	Q7Z478
QAPLPVLSPAAFVQS	CUX2	756	O14529
QVQVSFVSRIPVAFP	DMXL1	521	Q9Y485
VLPVPSSQVSFLEQA	CDHR4	226	A6H8M9
SPPVLVNAAQSVFVQ	ADNP2	661	Q6IQ32
SVQLPITLNKFFQPT	AP2A2	816	O94973
RVDLVVAPVSQFPFA	POLM	416	Q9NP87
TIVAVFPSPLAAQNA	R3HDM2	931	Q9Y2K5
LASLFSSLEPQIQPV	RBM34	56	P42696
LNPADAPNPVVFVAT	MTA2	596	O94776
QVVRTVINADFPFPL	SLC34A3	356	Q8N130
IQNPLAASLEATPAF	NRG1	591	Q02297
VVTVLQQLANEFPFP	PM20D1	291	Q6GTS8
LSSTVVPQVQAVFPE	ANK2	1171	Q01484
TFNVILAEPPVQFLA	OBSL1	1161	O75147
PVFPATQRNLFIAES	PCDHA7	131	Q9UN72
PVTNQAIAIPVTVAF	NUP210	1771	Q8TEM1
IPSLFALVLQNAPFS	RELCH	756	Q9P260
VQFPPTNVTILANAS	NPHS1	541	O60500
VPPLSSNVTLQVFVL	PCDHA11	541	Q9Y5I1
PQFQPLASVFTEIAR	DCHS1	3171	Q96JQ0
TNPASNLATVAILPV	PNPLA6	776	Q8IY17
PLPVVRVASVFANAD	PBRM1	1091	Q86U86
TVPSLPDNNALFVTA	NUDT4B	156	A0A024RBG1
ANPVNSTIPITAEVF	MDH2	141	P40926
LPDPFFQVQVLVSSA	CD300H	126	A0A0K2S4Q6
VSAQKLVFINAPVPS	KIAA2026	1501	Q5HYC2
VLALTPSVAPSLFQL	MCM3AP	1046	O60318
SPQSEPEVAAIVNFI	CPA5	296	Q8WXQ8
FLLPATQIIPTAQET	CPA5	406	Q8WXQ8
TTIIFDPQLAPNVVV	DSG4	921	Q86SJ6
AVINIDPSALQPNVF	DUOX2	546	Q9NRD8
ILAVSFAPLVQPSKN	PCMTD1	211	Q96MG8
FQAILSVNRPIPIAV	PLXNB3	1711	Q9ULL4
FTIFLPASVASLVQP	JRK	316	O75564
VPSLPDNNALFVTAA	NUDT4	156	Q9NZJ9
DFTFLRPLSVQQPTA	PCDHGC5	786	Q9Y5F6
IESPVFIATNQAQSP	NFE2L2	151	Q16236
STALANVSIPQPVAL	FAM205A	631	Q6ZU69
STALANVSIPQPVAL	FAM205BP	361	Q63HN1
STAAPDQRAPVFLVV	HEATR6	751	Q6AI08
SASVAAPAPAQSLQV	POU6F1	26	Q14863
ILTVESAQNFSLVPP	PRKD2	446	Q9BZL6
NPLEQAFITASLPNV	MRC2	1016	Q9UBG0
SQNTPLAQVFVPLES	GGA2	466	Q9UJY4
TQLPISAANVTIFRP	MUC5AC	516	P98088
TSAISFAEVQVQAPP	OXA1L	66	Q15070
FAEVQVQAPPVVAAT	OXA1L	71	Q15070
VPPLGSNVTLQVFVL	PCDHA5	541	Q9Y5H7
IQRNVTLFPPDVIAS	INSIG2	51	Q9Y5U4
AAVLITVVTPLLNPF	OR6M1	271	Q8NGM8
NIQPIFAVTSAALPV	ITGB7	341	P26010
NPPTFFVAVLTDINS	SBF1	61	O95248
LVAPAPVIISSSAAQ	PUM1	581	Q14671
VVALVTSVLTPFLNP	OR6V1	271	Q8N148
QSNVVIAPAAIARAP	MLXIP	606	Q9HAP2
LFQVISPQRIPATAA	DCP1B	506	Q8IZD4
VPAGIVIPSFQALTA	APOB	3871	P04114
LTIALPVPVIVSNFN	KCNA5	506	P22460
PLFPVFAVADQTISI	BSPRY	386	Q5W0U4
QFSLPSNVLPSLVLV	DNASE1L1	131	P49184
VRFPVSVTQQSPAAV	C2CD2L	161	O14523
QPTFPFAVANQLLLV	EIF2AK1	56	Q9BQI3
VAAIPAALPAQSSIV	CMYA5	1146	Q8N3K9
QTISFIPDFAVAIPT	COL6A3	1176	P12111
TLFTFRTQDPQQLPI	COL27A1	1821	Q8IZC6
PPRQFAAVSITTNQA	EPHA3	421	P29320
TTPLAQNAVQVPESF	ATF7IP2	536	Q5U623
ENVAVIPTVFSFNPA	MS4A18	286	Q3C1V0
PFAATATANQIPIIS	MBNL1	361	Q9NR56
IQLDSSPRFVVLFNP	MAN2A2	641	P49641
VLANTLINPQPITTF	EFHB	331	Q8N7U6
PKSLVSAPTQILAQF	EMSY	386	Q7Z589
VVDAASLLAPLPQVQ	ENGASE	606	Q8NFI3
VVTAFPSPRLLQQAL	EME2	311	A4GXA9
VQFPNLPRIDFSSIA	DDI2	86	Q5TDH0
LTPQQAQALEILFTP	FAM186A	1111	A6NE01
FQRPVLTASSFQPIE	FCRL2	106	Q96LA5
FVSTPFQVSVLENAP	CELSR3	651	Q9NYQ7
ILFAQSEPLVPSAAA	FAM83H	276	Q6ZRV2
EVASNPATITLFLPI	SLC13A1	486	Q9BZW2
VIFPNPLVSIAATAN	SALL3	371	Q9BXA9
PTLVFPNASTRNVVF	PTX4	271	Q96A99
DNAPLFPATVINISI	PCDH11Y	166	Q9BZA8
FPATVINISIPENSA	PCDH11Y	171	Q9BZA8
LIAIPAPQQILIATF	PANX2	651	Q96RD6
SASQDALPIVPQLQV	MAP3K1	1196	Q13233
IVFLFTPNVTELAQP	SLC6A19	251	Q695T7
SVFLQPVSLQTIAAA	TOM1L1	401	O75674
FALVQADSPSAPVNV	FNDC5	26	Q8NAU1
FAVPVFQSQIAPEAA	PPP1R1C	11	Q8WVI7
QVLFPPSVVLLEAAA	PPP1R16A	66	Q96I34
PIPALRAFSLQAAVV	PTCH1	566	Q13635
QLPTLNFSPEQVASV	SIX3	81	O95343
ATPVPLEFVQQAQSL	PRRC1	366	Q96M27
LLPSGIINPNVTAFI	ADSS2	81	P30520
VIPSQESVQLASQFP	OVCA2	181	Q8WZ82
PPALVTITNRFEQAF	PLA2R1	546	Q13018
PALNSTIQLPFIIIN	TFDP2	266	Q14188
QQLLTVTAAPTAAPV	SREBF1	211	P36956
LQLLNAQLSVPFPTI	MLLT10	771	P55197
LLSAAATQAVPAPNQ	ALDH2	16	P05091
PSFEVISAQPQLLFL	CIPC	116	Q9C0C6
NRLALPVNSSPAVIF	CHAT	206	P28329
ISNIARVSLFIPPQT	CLCA1	856	A8K7I4
SAVSNIAQAPLFIPP	CLCA2	876	Q9UQC9
AQPQSSPVQATFEVL	COASY	51	Q13057
EAIVPTLFNLVPNSA	CLASP2	176	O75122
LTAEAVNVAIAAPPS	C15orf40	81	Q8WUR7
AALNPEIVSVIPNAV	PIGA	196	P37287
LIPASQQATAPQVIV	GTF2A1	106	P52655
SPAVIPTLQNESFLL	MPDZ	81	O75970
ALFPVAQAPTALVAL	SLC16A13	296	Q7RTY0
SVFFTAVTPLLNPII	OR4E1	276	P0C645
TVTVLASAPALAPQV	SPATC1	331	Q76KD6
QVAAQVAAPVALPSP	PLCD3	21	Q8N3E9
LPLAPFTQLTAALVQ	TUT1	611	Q9H6E5
AAATVAPILATNTIP	SAP130	376	Q9H0E3
LDPNQPASAIVNFVS	TNS1	1711	Q9HBL0
AIPDLTAPVAAVQAA	VCL	36	P18206
AFPFTTPVLVSQLEQ	ZNF620	51	Q6ZNG0
SVAFTPLQGLEIVNP	PRPF31	451	Q8WWY3
PLAVPLGQTEVFQAL	THOC6	6	Q86W42
SPEQVTLLPVQRSFF	SLC6A9	26	P48067
FINNPNLTVRVPIAV	SCN8A	1086	Q9UQD0
AINPAALLPTAASQI	WASHC2C	941	Q9Y4E1
NIITASPISDLNPVF	XDH	351	P47989
SLASFPAAQIPIAVE	TACC2	421	O95359
LTILAIAPSVPFAAN	TTLL2	351	Q9BWV7
AVVLQSALQSIPNPS	USP9Y	1196	O00507
NVEPASLPSASVFVL	NUP153	1086	P49790
NTFSLQISVLDIPPF	UNC5D	746	Q6UXZ4
NSPLQIPVNAFDALT	TLR7	276	Q9NYK1
AVAQSPQTIPIATLL	YY1AP1	626	Q9H869
AFASNPEFVSIPAQI	TLN2	1576	Q9Y4G6
LVVIVASQLDNLFPP	SEMA3G	671	Q9NS98
FITNNLLLFIVPTPN	VN1R17P	146	Q8TDU5
VIQSQLPVFTRFDNP	TMTC3	256	Q6ZXV5
FTQNNAISESVPLPI	TMEM70	126	Q9BUB7
EFQVPVILTSQANAP	TCTN3	296	Q6NUS6
VQLPQQAAPVTAAAA	STK39	11	Q9UEW8
PNTTVQVPAFLQELV	USP48	426	Q86UV5
VPVLPAGIAQFLSLQ	ZHX3	261	Q9H4I2
VFIPQNVAPNASVLV	TG	2286	P01266
LQALPAAPFNITVTK	TYRO3	221	Q06418
IANVVSLASAPAAQP	ZMYM4	886	Q5VZL5
FAVNLNQEATSPPVL	ZP4	41	Q12836
TFVTAEQILAPLALP	ZNF804A	1016	Q7Z570
TFSPAVNVQAPVIGV	KLHL29	171	Q96CT2
FNPSSLALETIQIPA	MYO5A	1831	Q9Y4I1
VLIPPFETFQVINAS	ART1	241	P52961