Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP31 USP45 USP11 USP4 USP19 USP47	1.07e-06	114	59	6	GO:0004843
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP31 USP45 USP11 USP4 USP19 USP47 CAPN15	1.52e-06	192	59	7	GO:0008234
GeneOntologyMolecularFunction	deubiquitinase activity	USP31 USP45 USP11 USP4 USP19 USP47	1.75e-06	124	59	6	GO:0101005
GeneOntologyMolecularFunction	peptidase activity	USP31 TMPRSS9 USP45 USP11 PEPD USP4 CPD ADAM22 USP19 USP47 CAPN15	2.86e-06	654	59	11	GO:0008233
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP31 USP45 USP11 USP4 USP19 USP47	3.12e-06	137	59	6	GO:0019783
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	PDHA1 OGDH	3.05e-04	9	59	2	GO:0016624
GeneOntologyBiologicalProcess	protein deubiquitination	USP31 USP45 USP11 USP4 USP19 USP47	1.52e-06	125	59	6	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP31 USP45 USP11 USP4 USP19 USP47	3.47e-06	144	59	6	GO:0070646
Domain	USP_CS	USP31 USP45 USP11 USP4 USP19 USP47	6.00e-08	66	59	6	IPR018200
Domain	USP_1	USP31 USP45 USP11 USP4 USP19 USP47	8.58e-08	70	59	6	PS00972
Domain	UCH	USP31 USP45 USP11 USP4 USP19 USP47	9.35e-08	71	59	6	PF00443
Domain	USP_2	USP31 USP45 USP11 USP4 USP19 USP47	9.35e-08	71	59	6	PS00973
Domain	USP_3	USP31 USP45 USP11 USP4 USP19 USP47	1.02e-07	72	59	6	PS50235
Domain	USP_dom	USP31 USP45 USP11 USP4 USP19 USP47	1.02e-07	72	59	6	IPR028889
Domain	Peptidase_C19_UCH	USP31 USP45 USP11 USP4 USP19 USP47	1.02e-07	72	59	6	IPR001394
Domain	Ubiquitin_3	USP11 USP4	5.86e-05	4	59	2	PF14836
Domain	Ub_USP-typ	USP11 USP4	5.86e-05	4	59	2	IPR028135
Domain	EGF_3	SELP FBN1 TENM4 CELSR3 LRP1 ADAM22	9.61e-05	235	59	6	PS50026
Domain	EGF	SELP FBN1 TENM4 CELSR3 LRP1 ADAM22	9.61e-05	235	59	6	SM00181
Domain	EGF-like_dom	SELP FBN1 TENM4 CELSR3 LRP1 ADAM22	1.32e-04	249	59	6	IPR000742
Domain	DUSP	USP11 USP4	1.46e-04	6	59	2	SM00695
Domain	E1_dh	PDHA1 OGDH	1.46e-04	6	59	2	PF00676
Domain	DUSP	USP11 USP4	1.46e-04	6	59	2	PF06337
Domain	DH_E1	PDHA1 OGDH	1.46e-04	6	59	2	IPR001017
Domain	EGF_1	SELP FBN1 TENM4 CELSR3 LRP1 ADAM22	1.50e-04	255	59	6	PS00022
Domain	EGF-like_CS	SELP FBN1 TENM4 CELSR3 LRP1 ADAM22	1.70e-04	261	59	6	IPR013032
Domain	EGF_2	SELP FBN1 TENM4 CELSR3 LRP1 ADAM22	1.85e-04	265	59	6	PS01186
Domain	-	USP11 USP4	2.04e-04	7	59	2	3.30.2230.10
Domain	DUSP	USP11 USP4	2.04e-04	7	59	2	PS51283
Domain	Pept_C19_DUSP	USP11 USP4	2.04e-04	7	59	2	IPR006615
Domain	-	TENM4 LRP1 TRIM71	2.52e-04	39	59	3	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	TENM4 LRP1 TRIM71	4.13e-04	46	59	3	IPR011042
Domain	THDP-binding	PDHA1 OGDH	7.48e-04	13	59	2	IPR029061
Domain	-	PDHA1 OGDH	7.48e-04	13	59	2	3.40.50.970
Domain	NHL	TENM4 TRIM71	7.48e-04	13	59	2	PS51125
Domain	CarboxyPept-like_regulatory	TENM4 CPD	1.29e-03	17	59	2	IPR008969
Domain	cEGF	FBN1 LRP1	3.04e-03	26	59	2	IPR026823
Domain	cEGF	FBN1 LRP1	3.04e-03	26	59	2	PF12662
Domain	ASX_HYDROXYL	FBN1 CELSR3 LRP1	3.90e-03	100	59	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN1 CELSR3 LRP1	4.59e-03	106	59	3	IPR000152
Domain	EGF_CA	FBN1 CELSR3 LRP1	6.77e-03	122	59	3	SM00179
Domain	EGF-like_Ca-bd_dom	FBN1 CELSR3 LRP1	7.08e-03	124	59	3	IPR001881
Domain	EGF	SELP CELSR3 LRP1	7.40e-03	126	59	3	PF00008
Domain	BTB-kelch_protein	KLHL9 KLHL33	8.15e-03	43	59	2	IPR017096
Domain	Ldl_recept_a	TMPRSS9 LRP1	8.90e-03	45	59	2	PF00057
Domain	zf-C4	NR1H3 NR3C1	9.29e-03	46	59	2	PF00105
Domain	Znf_hrmn_rcpt	NR1H3 NR3C1	9.29e-03	46	59	2	IPR001628
Domain	Nuclear_hrmn_rcpt	NR1H3 NR3C1	9.29e-03	46	59	2	IPR001723
Domain	NUCLEAR_REC_DBD_2	NR1H3 NR3C1	9.29e-03	46	59	2	PS51030
Domain	NUCLEAR_REC_DBD_1	NR1H3 NR3C1	9.29e-03	46	59	2	PS00031
Domain	ZnF_C4	NR1H3 NR3C1	9.29e-03	46	59	2	SM00399
Domain	-	TMPRSS9 LRP1	9.29e-03	46	59	2	4.10.400.10
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP31 USP45 USP11 USP4 USP19 USP47	5.40e-09	81	59	6	12838346
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP31 USP45 USP11 USP4 USP19 USP47	1.93e-07	147	59	6	29576527
Pubmed	USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.	USP11 USP4 USP19	2.58e-07	8	59	3	22706160
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	YIF1A AHI1 IKZF2 SGMS1 POLD1 CERCAM HIC2 CPD ZNF841 USP19 ARSG	3.87e-07	925	59	11	28986522
Pubmed	The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice.	AHI1 NR3C1	2.83e-06	2	59	2	36691038
Pubmed	Protein S-glutathionylation alters superoxide/hydrogen peroxide emission from pyruvate dehydrogenase complex.	PDHA1 OGDH	2.83e-06	2	59	2	28242228
Pubmed	Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.	NR1H3 NR3C1	2.83e-06	2	59	2	22457708
Pubmed	Exome sequencing identified new mutations in a Marfan syndrome family.	FBN1 LRP1	2.83e-06	2	59	2	24484584
Pubmed	Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.	USP11 USP4 USP19 USP47	4.40e-06	64	59	4	33141564
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP45 KLHL9 PDHA1 MYO10 USP11 LRP1 USP4 OGDH USP19 USP47	6.75e-06	1005	59	10	19615732
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP31 USP45 USP47	8.02e-06	23	59	3	14715245
Pubmed	Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.	USP11 USP4	8.48e-06	3	59	2	26503449
Pubmed	Structural variability of the ubiquitin specific protease DUSP-UBL double domains.	USP11 USP4	8.48e-06	3	59	2	22001210
Pubmed	Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.	SELP LRP1	1.69e-05	4	59	2	15769472
Pubmed	The Arg/N-degron pathway targets transcription factors and regulates specific genes.	UBR1 NR3C1	1.69e-05	4	59	2	33229537
Pubmed	Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts.	CSMD1 ARSG	1.69e-05	4	59	2	19960030
Pubmed	The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the beta 2-microglobulin (B2m) gene on chromosome 2.	FBN1 IL1A	1.69e-05	4	59	2	7902327
Pubmed	Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons.	FBN1 KCNN3	2.82e-05	5	59	2	36812308
Pubmed	Genome-wide association study of serious blistering skin rash caused by drugs.	SLC22A23 ADAM22	2.82e-05	5	59	2	21221126
Pubmed	Tight-skin (Tsk) maps on mouse chromosome 2 within the region of linkage homology with human chromosome 15.	FBN1 IL1A	2.82e-05	5	59	2	7959775
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FBN1 CELSR3 LOXL2 LRP1 CERCAM CPD TYW1 ADAM22 USP19 DMXL1	3.13e-05	1201	59	10	35696571
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	FRRS1 SGMS1 MYO10 USP11 TMC6 PEPD USP4 CSMD1 OGDH ARSG	4.16e-05	1242	59	10	30973865
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 IL1A	4.23e-05	6	59	2	7873879
Pubmed	Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice.	ZC3H4 GFPT1	5.91e-05	7	59	2	18227763
Pubmed	Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.	NR1H3 NR3C1	7.87e-05	8	59	2	16143103
Pubmed	Phagocytosis imprints heterogeneity in tissue-resident macrophages.	SELP NR1H3	7.87e-05	8	59	2	28432199
Pubmed	Rhythmic modulation of the hematopoietic niche through neutrophil clearance.	SELP NR1H3	7.87e-05	8	59	2	23706740
Pubmed	The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.	USP11 USP4	1.01e-04	9	59	2	22195557
Pubmed	Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.	CDC16 IL1A	1.26e-04	10	59	2	14744933
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	YIF1A FRRS1 FBN1 PDHA1 LOXL2 LRP1 CERCAM CPD OGDH GFPT1	1.51e-04	1451	59	10	30550785
Pubmed	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.	FBN1 PKHD1	1.54e-04	11	59	2	17903305
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	TENM4 LOXL2 LRP1 CERCAM	1.77e-04	164	59	4	32409323
Pubmed	Genetic variation in the base excision repair pathway and bladder cancer risk.	POLD1 PARP3	1.85e-04	12	59	2	17203305
Pubmed	Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.	LRP1 NR1H3	1.85e-04	12	59	2	22027013
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KLHL9 SGMS1 LOXL2 SLC22A23 TMC6 PEPD LRP1 CPD CSMD1 OGDH	1.86e-04	1489	59	10	28611215
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 TENM4 LRP1	2.44e-04	71	59	3	33541421
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP11 USP4	2.93e-04	15	59	2	9827704
Pubmed	Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.	LRP1 IL1A	2.93e-04	15	59	2	11436125
Pubmed	MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.	POLD1 TYW1	2.93e-04	15	59	2	22678361
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FBN1 CELSR3 USP11 LRP1 CERCAM ZNF841 ADAM22 GFPT1 USP47	2.97e-04	1285	59	9	35914814
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	USP11 USP47 DMXL1	2.99e-04	76	59	3	27542412
Pubmed	A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene.	UBR1 FBN1	3.34e-04	16	59	2	7633422
Pubmed	Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.	SELP GFPT1	3.34e-04	16	59	2	12781685
Pubmed	CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.	USP11 USP47	3.34e-04	16	59	2	29979702
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	ATP6V0B PDHA1 MYO10 CDC16 SLC22A23 HIC2 GFPT1 USP19 CAPN15	3.76e-04	1327	59	9	32694731
Pubmed	Functional analysis of candidate genes from genome-wide association studies of hearing.	CSMD1 ARSG	3.79e-04	17	59	2	31927188
Pubmed	Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.	USP11 USP4	3.79e-04	17	59	2	29299163
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	FRRS1 ZC3H4 NR3C1 GFPT1 USP19	3.80e-04	363	59	5	14691545
Pubmed	Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS.	USP4 USP19	4.25e-04	18	59	2	30410068
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	TENM4 MYO10 ZC3H4 POLD1 SLC22A23 KCNN3 CSMD1	4.44e-04	814	59	7	23251661
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	UBR1 POLD1 CDC16 USP47	4.70e-04	212	59	4	33853758
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	ATP6V0B PARP3 TMC6 CERCAM CSMD1 KLHL33 ZNF445	5.06e-04	832	59	7	36724073
Pubmed	Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians.	SELP IL1A	5.82e-04	21	59	2	20227257
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TENM4 ZC3H4 TOGARAM1 HIC2	5.87e-04	225	59	4	12168954
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	SELP LRP1 NR3C1 IL1A	6.27e-04	229	59	4	19948975
Pubmed	Nuclear receptors in Leydig cell gene expression and function.	NR1H3 NR3C1	6.39e-04	22	59	2	20375256
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	YIF1A TENM4 LYG2	7.07e-04	102	59	3	21926972
Pubmed	CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.	PDHA1 OGDH	8.28e-04	25	59	2	28188211
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	USP31 PDHA1 USP11 POLD1 CPD TYW1 NR3C1 OGDH DMXL1	8.51e-04	1487	59	9	33957083
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	FBN1 IL1A	9.66e-04	27	59	2	11518254
Pubmed	Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.	USP4 USP47	1.04e-03	28	59	2	22118674
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	USP11 POLD1 LRP1 CPD OGDH GFPT1	1.07e-03	686	59	6	28380382
Pubmed	Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.	LRP1 TRIM71	1.19e-03	30	59	2	21946350
Pubmed	Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.	LRP1 NR1H3	1.27e-03	31	59	2	19796621
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP11 USP4 USP19 USP47 CAPN15	1.34e-03	481	59	5	28190767
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP11 USP4	1.36e-03	32	59	2	33669244
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	AHI1 OGDH ADAM22	1.36e-03	128	59	3	30995482
Pubmed	Determination of genetic predisposition to patent ductus arteriosus in preterm infants.	KCNN3 NR3C1 IL1A	1.39e-03	129	59	3	19336370
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP11 USP4	1.44e-03	33	59	2	30323974
Pubmed	Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.	SELP IL1A	1.44e-03	33	59	2	19028820
Pubmed	Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis.	SELP IL1A	1.44e-03	33	59	2	18974840
Pubmed	Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.	SELP IL1A	1.53e-03	34	59	2	20603037
Pubmed	USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.	USP11 USP4	1.62e-03	35	59	2	33378683
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	CELSR3 PARP3 USP4 USP19 ZNF445	5.53e-05	316	59	5	chr3p21
GeneFamily	Ubiquitin specific peptidases	USP31 USP45 USP11 USP4 USP19 USP47	3.74e-09	56	43	6	366
GeneFamily	Kelch like\|BTB domain containing	KLHL9 KLHL33	4.48e-03	42	43	2	617
GeneFamily	Nuclear hormone receptors	NR1H3 NR3C1	6.05e-03	49	43	2	71
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP CSMD1	8.12e-03	57	43	2	1179
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000	USP31 RGMB AHI1 MYO10 CPD	5.33e-05	146	59	5	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_M-vs-F_top274_274	USP45 IKZF2 TOGARAM1 CPD ZNF841 GFPT1	7.64e-05	256	59	6	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_250_M-vs-F
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000	USP31 RGMB AHI1 TENM4 MYO10 TRIM71 CPD	9.25e-05	385	59	7	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#2_top-relative-expression-ranked_500	FBN1 TENM4 USP11 LOXL2 LRP1	9.51e-05	165	59	5	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k2_500
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_500	ATP6V0B TENM4 TRIM71 DMXL1	1.20e-04	91	59	4	gudmap_developingGonad_e12.5_ovary_k5_500
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	USP31 CROT FRRS1 IKZF2 LRP1	3.55e-06	175	59	5	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 LRP1 NR1H3 ADAM22	6.02e-05	160	59	4	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	BL-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IKZF2 LYG2 ADAM22 ZNF124	6.32e-05	162	59	4	25ec9df914445b4daae4fd28fd0e60b64797c46d
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 TENM4 LOXL2 LYG2	9.29e-05	179	59	4	ff678e2f33c914e3dd0f338ada25f506c3e3c980
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATP6V0B MYO10 SLC22A23 PXK	1.06e-04	185	59	4	9438097e94219c1db922b8507e3a29106d32a923
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FBN1 TENM4 SLC22A23 NR3C1	1.06e-04	185	59	4	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IKZF2 SLC22A23 PKHD1 TRIM71	1.08e-04	186	59	4	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LRP1 CERCAM CSMD1	1.08e-04	186	59	4	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TENM4 PKHD1 LRP1 CSMD1	1.08e-04	186	59	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM4 SGMS1 PKHD1 CPD	1.19e-04	191	59	4	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN1 LOXL2 LRP1 CERCAM	1.22e-04	192	59	4	32acd89617934016cd135d2cc797e8e79ae1b37f
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN1 LOXL2 LRP1 CERCAM	1.22e-04	192	59	4	321850b0f881420c2d57d3e825e365c82fa511ab
ToppCell	facs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.22e-04	192	59	4	a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN1 LOXL2 LRP1 CERCAM	1.22e-04	192	59	4	cf2765d8bc074f7f9ee864eae632a3b705175842
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN1 LOXL2 LRP1 CERCAM	1.22e-04	192	59	4	7b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCell	facs-Lung-nan-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.22e-04	192	59	4	eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.22e-04	192	59	4	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	facs-Heart-RV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.24e-04	193	59	4	735a72fac16397edde95e8eefa6f83caeb5ee5df
ToppCell	facs-Heart-RV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.24e-04	193	59	4	ff901d2f3d7a511639c1e3b76058896c0d8a8602
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.24e-04	193	59	4	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.24e-04	193	59	4	160691b671710be10220803d788c2c961c236af1
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.32e-04	196	59	4	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.32e-04	196	59	4	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	USP31 CROT TENM4 SLC22A23	1.34e-04	197	59	4	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.37e-04	198	59	4	1b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCell	tumor_Lung-Fibroblasts-Myofibroblasts\|tumor_Lung / Location, Cell class and cell subclass	FBN1 LOXL2 LRP1 CERCAM	1.37e-04	198	59	4	31f9181dab689aabe9c6182c2ef7de65ba3f0ff6
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 TENM4 CSMD1 ADAM22	1.37e-04	198	59	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	facs-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 LOXL2 LRP1 CERCAM	1.37e-04	198	59	4	0dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	USP31 CROT TENM4 CSMD1	1.40e-04	199	59	4	94a7867e800df352731796de8c24cba133c29622
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHI1 FBN1 POLD1 LRP1	1.40e-04	199	59	4	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts\|LPS_only / Treatment groups by lineage, cell group, cell type	FBN1 MYO10 POLD1 LRP1	1.40e-04	199	59	4	1a0add79f4e34078b3475eb11c85a4234bda197c
ToppCell	LPS_only-Mesenchymal_fibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	FBN1 MYO10 POLD1 LRP1	1.40e-04	199	59	4	211c3a08f2d484ab7a3368006767289088f0d957
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	USP31 CROT TENM4 SLC22A23	1.42e-04	200	59	4	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	Sigmoid-T_cell-Tfh\|T_cell / Region, Cell class and subclass	LOXL2 LYG2 NR1H3 HIC2	1.42e-04	200	59	4	dd7dcf25520f065bf0d33d589f3c176f63875dc9
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 LOXL2 LRP1 KCNN3	1.42e-04	200	59	4	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
Disease	Joubert syndrome (implicated_via_orthology)	AHI1 TOGARAM1	7.65e-05	7	57	2	DOID:0050777 (implicated_via_orthology)
Disease	aortic aneurysm	FBN1 LRP1	1.63e-04	10	57	2	EFO_0001666
Disease	squamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma	PKHD1 CSMD1	2.82e-04	13	57	2	EFO_0000707, EFO_0004193, EFO_0007932
Disease	Stevens-Johnson syndrome, toxic epidermal necrolysis	SLC22A23 ADAM22	4.89e-04	17	57	2	EFO_0004276, EFO_0004775
Disease	obesity (is_implicated_in)	NR1H3 NR3C1 GFPT1	7.36e-04	91	57	3	DOID:9970 (is_implicated_in)
Disease	Splenomegaly	PEPD KCNN3	8.26e-04	22	57	2	C0038002
Disease	glucose measurement	PDHA1 ZC3H4 NR1H3 OGDH USP47	8.34e-04	380	57	5	EFO_0004468
Disease	multiple sclerosis	USP31 AHI1 IKZF2 TRIM71 NR3C1 CSMD1	9.86e-04	594	57	6	MONDO_0005301
Disease	obsolete_red blood cell distribution width	AHI1 SGMS1 ZC3H4 SLC22A23 TMC6 PEPD USP4 ARSG USP47	1.04e-03	1347	57	9	EFO_0005192
Disease	uveitis (biomarker_via_orthology)	NR3C1 IL1A	1.07e-03	25	57	2	DOID:13141 (biomarker_via_orthology)
Disease	psychosis predisposition measurement	TRIM71 CSMD1	1.16e-03	26	57	2	EFO_0008337
Disease	spontaneous coronary artery dissection	FBN1 LRP1	1.64e-03	31	57	2	EFO_0010820
Disease	serum gamma-glutamyl transferase measurement	UBR1 IKZF2 TENM4 PEPD PKHD1 KCNN3 CSMD1	1.84e-03	914	57	7	EFO_0004532

Protein segments in the cluster

Peptide	Gene	Start	Entry
HYFCKPGYRMVGHSN	CSMD1	2456	Q96PZ7
MSHGTYYECEPRGGQ	CEBPE	1	Q15744
GHHMYSGDCTGVIVV	AHI1	756	Q8N157
LSTCHGLHGMFYDGN	ADAM22	151	Q9P0K1
YSHDMGCTDTPGYNH	ARSG	161	Q96EG1
RMFLSYCILHGSHGG	DMXL1	2131	Q9Y485
FEHYCYSRGGMRHSS	PEPD	226	P12955
CGAHHVGYMFLGEVA	PARP3	431	Q9Y6F1
HYICHSGGHCPMDTY	NR1H3	131	Q13133
RHEGREGMTCYYLTH	CAPN15	966	O75808
YHVSYGPLHEGCMDQ	IL1A	36	P01583
GCGGTGQYLASLMHY	KLHL33	376	A6NCF5
CTMGRHGGHSFIYLQ	TRIM71	301	Q2Q1W2
VYATLYMGGHGSRHS	LRP1	4506	Q07954
YDGHRIWMYNCHIGG	LOXL2	736	Q9Y4K0
LSIGYGDMVPHTYCG	KCNN3	506	Q9UGI6
HRQEMTSTVYCHGGG	MYO10	1696	Q9HD67
HYGHAGTVYGGLMYI	KLHL9	436	Q9P2J3
VHGVSTSGGQMYHYD	NR3C1	321	P04150
YTIHMGCHGYRDPLE	IKZF2	486	Q9UKS7
DEGSGDVKYHLGMYH	OGDH	341	Q02218
GCYYLMVGHKNEHAR	CDC16	306	Q13042
VCVDTHMRSTCYGGY	FBN1	651	P35555
RHAGYHPYLGCIVMT	FRRS1	441	Q6ZNA5
HLGSMKDYSVTYGHC	CPD	1161	O75976
GTMYCRHHPGTFGFN	SELP	651	P16109
LHPRLYHGCYGDIMT	LYG2	31	Q86SG7
VGGYFGHHCEHRMDQ	CELSR3	2011	Q9NYQ7
GVSVHVCNEHRYGYM	CERCAM	256	Q5T4B2
ELCSRESMFGYHGHG	POLD1	191	P28340
GCCYETAMTRHFYHG	CROT	436	Q9UKG9
GGSGHASAHYMYRQE	HIC2	416	Q96JB3
GHYVEMHARYIGTTV	RGMB	266	Q6NW40
MGRGYHYATCLEGAL	GFPT1	561	Q06210
GYGIHHCFARSMMGH	SLC22A23	441	A1A5C7
CTHVYGYAFGHMHDN	SLC25A41	46	Q8N5S1
LLGGAMYYLEAEHHG	PKHD1	446	P08F94
QHYLSCGGSYPSMGH	PRR12	311	Q9ULL5
NHYGGMIGGHYTACA	USP19	1156	O94966
SNHYGAMGVGHYTAY	USP4	871	Q13107
MAYHSGYGAHGSKHR	YIF1A	1	O95070
VEHSGSMREGHYTAY	USP45	736	Q70EL2
TYRYHGHSMSDPGVS	PDHA1	286	P08559
IGHRNYHAGYSMFGA	ATP6V0B	126	Q99437
SVMVHSGSAAGGHYY	USP47	491	Q96K76
HRYKMHTSTGGGFCD	UBR1	136	Q8IWV7
AYGTYTGSCGHVMHA	UBR1	1151	Q8IWV7
LYGHSLTDRMVCAGY	TMPRSS9	361	Q7Z410
HCFGHLLYEMTYGRP	PXK	336	Q7Z7A4
YRTDIGLPHCGYSMG	TENM4	96	Q6N022
TGSHNMCGDYLYSGH	SGMS1	271	Q86VZ5
YMHGDFPCKLYHTTG	ZC3H4	441	Q9UPT8
RDTVMHTGNGHYGCT	ZNF124	111	Q15973
YGGYLSVHMRCHTGE	ZNF841	436	Q6ZN19
GCGKHFRMSSHHYDY	ZNF445	416	P59923
GAGCFTHTVMYYGHY	TMC6	296	Q7Z403
HGTMQGGHYTAYCKN	USP31	716	Q70CQ4
RGGCYKHTFYGIESH	TYW1	391	Q9NV66
CGDHVRDSMHIYGSY	TOGARAM1	626	Q9Y4F4
AVSNHYGGMRDGHYT	USP11	876	P51784