Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendopeptidase activity

KLK15 ADAMTS1 PRSS21 KLK12 C1RL ADAMTS13 PRSS36

1.05e-04430517GO:0004175
GeneOntologyMolecularFunctionserine-type endopeptidase activity

KLK15 PRSS21 KLK12 C1RL PRSS36

1.22e-04190515GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

KLK15 PRSS21 KLK12 C1RL PRSS36

1.82e-04207515GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

KLK15 PRSS21 KLK12 C1RL PRSS36

2.03e-04212515GO:0017171
GeneOntologyMolecularFunctionpeptidase activity

KLK15 ADAMTS1 PRSS21 KLK12 C1RL ADAMTS13 IHH PRSS36

2.33e-04654518GO:0008233
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

VRK1 TIE1 CSNK1D CSNK1E COQ8B PKM DGKQ RPS6KL1

4.00e-04709518GO:0016773
GeneOntologyMolecularFunctionkinase activity

VRK1 TIE1 CSNK1D CSNK1E COQ8B PKM DGKQ RPS6KL1

6.56e-04764518GO:0016301
GeneOntologyMolecularFunctionprotein kinase activity

VRK1 TIE1 CSNK1D CSNK1E COQ8B PKM RPS6KL1

7.85e-04600517GO:0004672
GeneOntologyBiologicalProcessketone biosynthetic process

COQ8B DGKQ COQ3 SIRT5

1.19e-0557514GO:0042181
GeneOntologyCellularComponentextracellular matrix

SSC5D FCGBP CD248 ADAMTS1 PKM ADAMTS13 IHH SSPOP MUC5AC

3.07e-05656529GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

SSC5D FCGBP CD248 ADAMTS1 PKM ADAMTS13 IHH SSPOP MUC5AC

3.15e-05658529GO:0030312
DomainTIL

FCGBP SSPOP MUC5AC

4.15e-0612513PF01826
DomainC8

FCGBP SSPOP MUC5AC

4.15e-0612513PF08742
DomainUnchr_dom_Cys-rich

FCGBP SSPOP MUC5AC

5.38e-0613513IPR014853
DomainC8

FCGBP SSPOP MUC5AC

5.38e-0613513SM00832
DomainTIL_dom

FCGBP SSPOP MUC5AC

6.84e-0614513IPR002919
DomainTRYPSIN_HIS

KLK15 PRSS21 KLK12 C1RL PRSS36

8.88e-06103515IPR018114
DomainTRYPSIN_SER

KLK15 PRSS21 KLK12 C1RL PRSS36

1.02e-05106515PS00135
DomainVWD

FCGBP SSPOP MUC5AC

1.05e-0516513SM00216
DomainVWF_type-D

FCGBP SSPOP MUC5AC

1.05e-0516513IPR001846
DomainVWFD

FCGBP SSPOP MUC5AC

1.05e-0516513PS51233
DomainVWD

FCGBP SSPOP MUC5AC

1.05e-0516513PF00094
DomainTRYPSIN_HIS

KLK15 PRSS21 KLK12 C1RL PRSS36

1.07e-05107515PS00134
DomainPeptidase_S1A

KLK15 PRSS21 KLK12 C1RL PRSS36

1.40e-05113515IPR001314
DomainTRYPSIN_DOM

KLK15 PRSS21 KLK12 C1RL PRSS36

1.52e-05115515PS50240
DomainTryp_SPc

KLK15 PRSS21 KLK12 C1RL PRSS36

1.65e-05117515SM00020
DomainVWC_out

FCGBP SSPOP MUC5AC

1.80e-0519513SM00215
DomainTrypsin

KLK15 PRSS21 KLK12 C1RL PRSS36

1.94e-05121515PF00089
DomainTrypsin_dom

KLK15 PRSS21 KLK12 C1RL PRSS36

1.94e-05121515IPR001254
DomainPeptidase_S1_PA

KLK15 PRSS21 KLK12 C1RL PRSS36

2.10e-05123515IPR009003
DomainTSP_1

THSD7A ADAMTS1 ADAMTS13 SSPOP

2.61e-0563514PF00090
DomainTSP1

THSD7A ADAMTS1 ADAMTS13 SSPOP

2.95e-0565514SM00209
DomainTSP1_rpt

THSD7A ADAMTS1 ADAMTS13 SSPOP

2.95e-0565514IPR000884
DomainTSP1

THSD7A ADAMTS1 ADAMTS13 SSPOP

2.95e-0565514PS50092
DomainTRYPSIN_SER

PRSS21 KLK12 C1RL PRSS36

1.06e-0490514IPR033116
DomainVWC

FCGBP SSPOP MUC5AC

1.51e-0438513SM00214
DomainVWF_dom

FCGBP SSPOP MUC5AC

2.04e-0442513IPR001007
DomainCUB

C1RL ADAMTS13 PDGFC

4.08e-0453513PS01180
DomainCUB_dom

C1RL ADAMTS13 PDGFC

5.06e-0457513IPR000859
DomainCTCK_1

SSPOP MUC5AC

1.09e-0318512PS01185
DomainSRCR

SSC5D SSC4D

1.49e-0321512PF00530
DomainPeptidase_M12B_ADAM-TS

ADAMTS1 ADAMTS13

1.94e-0324512IPR013273
DomainSR

SSC5D SSC4D

2.11e-0325512SM00202
Domain-

SSC5D SSC4D

2.11e-03255123.10.250.10
DomainCys_knot_C

SSPOP MUC5AC

2.11e-0325512IPR006207
DomainCTCK_2

SSPOP MUC5AC

2.11e-0325512PS01225
DomainPROTEIN_KINASE_DOM

VRK1 TIE1 CSNK1D CSNK1E COQ8B RPS6KL1

2.16e-03493516PS50011
DomainSRCR_1

SSC5D SSC4D

2.28e-0326512PS00420
DomainSRCR_2

SSC5D SSC4D

2.28e-0326512PS50287
DomainSRCR-like_dom

SSC5D SSC4D

2.28e-0326512IPR017448
DomainACR

ADAMTS1 ADAMTS13

2.46e-0327512SM00608
DomainADAM_Cys-rich

ADAMTS1 ADAMTS13

2.46e-0327512IPR006586
DomainSRCR

SSC5D SSC4D

2.46e-0327512IPR001190
DomainKinase-like_dom

VRK1 TIE1 CSNK1D CSNK1E COQ8B RPS6KL1

3.46e-03542516IPR011009
DomainEGF_3

CELSR3 TIE1 CD248 SSPOP

3.84e-03235514PS50026
DomainEGF

FCGBP CELSR3 TIE1 CD248

3.84e-03235514SM00181
DomainVWFC_1

SSPOP MUC5AC

4.34e-0336512PS01208
DomainEGF-like_dom

FCGBP CELSR3 TIE1 CD248

4.72e-03249514IPR000742
DomainVWFC_2

SSPOP MUC5AC

4.83e-0338512PS50184
DomainEGF

CELSR3 TIE1 CD248

4.93e-03126513PF00008
DomainEGF_1

CELSR3 TIE1 CD248 SSPOP

5.13e-03255514PS00022
DomainDISINTEGRIN_1

ADAMTS1 ADAMTS13

5.34e-0340512PS00427
DomainReprolysin

ADAMTS1 ADAMTS13

5.34e-0340512PF01421
DomainADAM_MEPRO

ADAMTS1 ADAMTS13

5.34e-0340512PS50215
DomainDISINTEGRIN_2

ADAMTS1 ADAMTS13

5.34e-0340512PS50214
DomainPeptidase_M12B

ADAMTS1 ADAMTS13

5.34e-0340512IPR001590
DomainDisintegrin_dom

ADAMTS1 ADAMTS13

5.60e-0341512IPR001762
DomainEGF_2

CELSR3 TIE1 CD248 SSPOP

5.87e-03265514PS01186
DomainCUB

C1RL PDGFC

7.92e-0349512PF00431
DomainPROTEIN_KINASE_ATP

VRK1 TIE1 CSNK1D CSNK1E RPS6KL1

8.14e-03459515PS00107
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

THSD7A ADAMTS1 ADAMTS13 SSPOP MUC5AC

1.30e-0668405M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD7A ADAMTS1 ADAMTS13 SSPOP

4.25e-0639404M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD7A ADAMTS1 ADAMTS13 SSPOP

4.25e-0639404MM15165
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD7A ADAMTS1 ADAMTS13 SSPOP MUC5AC

1.34e-05109405MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD7A ADAMTS1 ADAMTS13 SSPOP MUC5AC

1.46e-05111405M27416
PathwayPID_BETA_CATENIN_DEG_PATHWAY

CSNK1D CSNK1E SSPOP

1.68e-0518403M31
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

THSD7A ADAMTS1 ADAMTS13 SSPOP MUC5AC

4.95e-05143405M27275
PathwayWP_HEDGEHOG_SIGNALING_WP4249

CSNK1D CSNK1E IHH

2.41e-0443403M39706
PathwayPID_HEDGEHOG_GLI_PATHWAY

CSNK1D CSNK1E SSPOP

3.35e-0448403M219
PathwayKEGG_HEDGEHOG_SIGNALING_PATHWAY

CSNK1D CSNK1E IHH

5.29e-0456403M1053
PathwayREACTOME_UBIQUINOL_BIOSYNTHESIS

COQ8B COQ3

6.00e-0413402MM17216
PathwayREACTOME_UBIQUINOL_BIOSYNTHESIS

COQ8B COQ3

6.00e-0413402M27142
PathwayKEGG_CIRCADIAN_RHYTHM_MAMMAL

CSNK1D CSNK1E

6.00e-0413402M18009
PathwayREACTOME_DISEASES_OF_METABOLISM

THSD7A ADAMTS1 ADAMTS13 SSPOP MUC5AC

6.68e-04250405M27554
Pubmed

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.

CSNK1D CSNK1E

2.37e-06254225404202
Pubmed

Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

CSNK1D CSNK1E

2.37e-06254219043076
Pubmed

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth.

PKM SIRT5

2.37e-06254228036303
Pubmed

CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.

CSNK1D CSNK1E

2.37e-06254224424021
Pubmed

Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.

CSNK1D CSNK1E

2.37e-0625429632646
Pubmed

An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.

CSNK1D CSNK1E

2.37e-06254222981886
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

WDR6 CSNK1D PRSS21 COQ8B IFFO2 C1RL MIB2 ZNF692 FUBP3 RPS6KL1

3.37e-061021541026760575
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

THSD7A ADAMTS1 ADAMTS13 SSPOP

5.81e-067554420637190
Pubmed

Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.

CSNK1D CSNK1E

7.09e-06354227439882
Pubmed

Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.

CSNK1D CSNK1E

7.09e-06354225724478
Pubmed

A comparative study of structural and conformational properties of casein kinase-1 isoforms: insights from molecular dynamics and principal component analysis.

CSNK1D CSNK1E

7.09e-06354225665722
Pubmed

CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.

CSNK1D CSNK1E

7.09e-06354219805222
Pubmed

CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.

CSNK1D CSNK1E

7.09e-06354232321936
Pubmed

Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.

CSNK1D CSNK1E

7.09e-06354212270714
Pubmed

Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.

CSNK1D CSNK1E

7.09e-06354228963394
Pubmed

Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.

CSNK1D CSNK1E

7.09e-06354231353086
Pubmed

Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.

CSNK1D CSNK1E

7.09e-0635428786104
Pubmed

Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.

CSNK1D CSNK1E

7.09e-06354222384121
Pubmed

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.

CSNK1D CSNK1E

1.42e-05454229784789
Pubmed

Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.

CSNK1D CSNK1E

1.42e-05454237578019
Pubmed

Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.

KLK15 KLK12

1.42e-05454211006094
Pubmed

Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro.

CSNK1D CSNK1E

1.42e-05454220421981
Pubmed

Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

CSNK1D CSNK1E

1.42e-05454221422228
Pubmed

Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.

CSNK1D CSNK1E

1.42e-05454215070676
Pubmed

The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.

CSNK1D CSNK1E

1.42e-05454220192920
Pubmed

Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.

CSNK1D CSNK1E

1.42e-05454231334659
Pubmed

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs.

CSNK1D CSNK1E

1.42e-0545429349507
Pubmed

Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.

CSNK1D CSNK1E

1.42e-0545427797465
Pubmed

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.

ADAMTS1 ADAMTS13

1.42e-05454229135310
Pubmed

Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.

CSNK1D CSNK1E

2.36e-05554210848614
Pubmed

Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.

CSNK1D CSNK1E

2.36e-05554229191835
Pubmed

Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes.

CSNK1D CSNK1E

2.36e-05554229463694
Pubmed

Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors.

GPR150 GPR153

2.36e-05554224503482
Pubmed

Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.

CSNK1D CSNK1E

2.36e-05554211865049
Pubmed

Casein kinase 1 delta regulates the pace of the mammalian circadian clock.

CSNK1D CSNK1E

2.36e-05554219414593
Pubmed

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin.

CSNK1D CSNK1E

2.36e-05554217027228
Pubmed

The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer.

CSNK1D CSNK1E

2.36e-05554233754069
Pubmed

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.

CSNK1D CSNK1E

2.36e-05554219948962
Pubmed

The new human kallikrein gene family: implications in carcinogenesis.

KLK15 KLK12

3.54e-05654210675891
Pubmed

Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.

CSNK1D CSNK1E

3.54e-05654222609948
Pubmed

Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.

CSNK1D CSNK1E

3.54e-05654218708403
Pubmed

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).

CSNK1D CSNK1E

3.54e-05654220048001
Pubmed

Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.

CSNK1D CSNK1E

3.54e-05654217962809
Pubmed

Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.

CSNK1D CSNK1E

3.54e-05654211818547
Pubmed

Physiological role for casein kinase 1 in glutamatergic synaptic transmission.

CSNK1D CSNK1E

3.54e-05654216014721
Pubmed

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.

CSNK1D CSNK1E

3.54e-05654221179498
Pubmed

Modeling of a human circadian mutation yields insights into clock regulation by PER2.

CSNK1D CSNK1E

4.94e-05754217218255
Pubmed

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.

CSNK1D CSNK1E

4.94e-05754212000790
Pubmed

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.

CSNK1D CSNK1E

4.94e-05754234353330
Pubmed

SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.

CSNK1D CSNK1E

4.94e-05754230177679
Pubmed

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.

CSNK1D CSNK1E

6.59e-05854217244647
Pubmed

Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.

CSNK1D CSNK1E

6.59e-05854217101137
Pubmed

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.

CSNK1D CSNK1E

6.59e-05854221930935
Pubmed

Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1.

CSNK1D CSNK1E

6.59e-05854216618118
Pubmed

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

CACNA1D TIE1

8.46e-0595428415706
Pubmed

Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.

GPR150 GPR153

8.46e-05954215777626
Pubmed

SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.

CSNK1D CSNK1E

8.46e-05954236828627
Pubmed

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.

CSNK1D CSNK1E

8.46e-05954220708156
Pubmed

Organization and evolution of the glandular kallikrein locus in Mus musculus.

KLK15 KLK12

1.06e-041054212437987
Pubmed

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

CSNK1D CSNK1E

1.06e-041054225500533
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS1 ADAMTS13

1.55e-041254225770910
Pubmed

Human tissue kallikreins: physiologic roles and applications in cancer.

KLK15 KLK12

1.83e-041354215192120
Pubmed

Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.

CSNK1D CSNK1E

1.83e-041354218228528
Pubmed

A molecular mechanism for circadian clock negative feedback.

CSNK1D CSNK1E

1.83e-041354221680841
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THSD7A SSPOP MUC5AC

1.88e-047154333541421
Pubmed

Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

KLK15 KLK12

2.13e-041454211054574
Pubmed

Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains.

KLK15 KLK12

2.13e-041454225666037
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

CSNK1D CSNK1E CPOX

2.30e-047654327542412
Pubmed

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.

KLK15 KLK12

2.45e-041554215203212
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

CELSR3 SSPOP

2.45e-041554220473291
Pubmed

Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005.

KLK15 KLK12

2.45e-041554216800723
Pubmed

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.

KLK15 KLK12

2.45e-041554216800724
Pubmed

Association of CPI-17 with protein kinase C and casein kinase I.

CSNK1D CSNK1E

2.45e-041554215003508
Pubmed

GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.

IHH MUC5AC

2.80e-041654226932670
Pubmed

USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.

CSNK1D CSNK1E

2.80e-041654229045831
Pubmed

Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.

KLK15 KLK12

2.80e-041654220424135
Pubmed

SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.

CSNK1E IHH

3.56e-041854225761772
Pubmed

Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus.

TIE1 IHH

3.56e-041854220123094
Pubmed

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.

CSNK1D CSNK1E

4.88e-042154219839995
Pubmed

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract.

IHH MUC5AC

5.36e-042254220430747
Pubmed

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.

CSNK1D CSNK1E

5.36e-042254222305495
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

PKM MIB2 FUBP3

6.26e-0410754330995489
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

FCGBP DSC2 ADAMTS13 IHH

6.89e-0425754416335952
Pubmed

Extra-embryonic vasculature development is regulated by the transcription factor HAND1.

TIE1 IHH

8.72e-042854215073150
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

THSD7A CELSR3 SSPOP

1.10e-0313054312421765
Pubmed

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

CD248 PRSS21 IL27RA

1.15e-0313254326439863
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

NAT14 ADAMTS1 COQ8B SIRT5

1.19e-0329854432353859
GeneFamilyKallikreins

KLK15 KLK12

4.29e-0416352616
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS1 ADAMTS13

6.10e-041935250
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SSC5D SSC4D

1.24e-03273521253
GeneFamilyProteases, serine

PRSS21 PRSS36

6.60e-0363352738
GeneFamilyG protein-coupled receptors, Class A orphans

GPR150 GPR153

9.97e-0378352262
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KMT2D SSC4D WDR97 IFFO2 IHH

2.99e-06185545636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-goblet|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK15 FCGBP KLK12 IHH MUC5AC

4.17e-061985459c5d7852f03468394e726c444cac92a043fc6d0e
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK15 FCGBP KLK12 IHH MUC5AC

4.17e-06198545f95f38cc747fb3549a791288bf8d0518c049ac96
ToppCelllung-Club_Cells|lung / shred on tissue and cell subclass

FCGBP DSC2 PDGFC PRSS36

4.67e-05164544b12cacd499b18b96120ca6d14646aebeaed41d10
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

5.01e-0516754431633899aae852873a4887e72c621474b0a51a33
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP THSD7A WDR97 ADAMTS13

5.01e-051675448fede587572d465cb63f7828141a574185bbb819
ToppCelldroplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D TIE1 CD248 GPR153

5.37e-0517054410e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SHROOM1 THSD7A TIE1 ADAMTS1

5.49e-051715441597459c971d6befa991d59dc66b41b6a522f797
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

5.75e-05173544e8afef5ae68983eb8d6515b43952636a47e9d3d4
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

5.75e-051735443aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK15 FCGBP IHH MUC5AC

5.88e-05174544e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK15 FCGBP IHH MUC5AC

5.88e-05174544ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)|367C / Donor, Lineage, Cell class and subclass (all cells)

SHROOM1 THSD7A TIE1 ADAMTS1

6.42e-05178544e1e96a0e3ff718ebf676a982bc63e8ced6984059
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)-|367C / Donor, Lineage, Cell class and subclass (all cells)

SHROOM1 THSD7A TIE1 ADAMTS1

6.42e-05178544363e8b23b3834692a8a79e5fdc7b43bd3a4dab5e
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHROOM1 THSD7A TIE1 ADAMTS1

6.56e-051795441ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

7.00e-0518254494e70746e35a3062015d4b83ee545f4f84f47420
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SHROOM1 THSD7A TIE1 ADAMTS1

7.45e-05185544a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|343B / Donor, Lineage, Cell class and subclass (all cells)

FCGBP DSC2 PDGFC PRSS36

7.45e-05185544d4ba36bdb8b7e3a62e827269484f89f790eaa5ef
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

SHROOM1 THSD7A TIE1 ADAMTS1

7.77e-0518754440ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP MCHR2 KLK12 MUC5AC

7.93e-051885445901b276f2379abf486b8285957277e95f08464e
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery|Children_(3_yrs) / Lineage, Cell type, age group and donor

SHROOM1 THSD7A TIE1 ADAMTS1

8.26e-05190544f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCellGoblet|World / shred by cell class for turbinate

FCGBP KLK12 SLC16A11 MUC5AC

8.95e-0519454403b62e7cff5e7a6e7bd7d9dda273c74bf9c1f42e
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

9.32e-05196544020110cd79453df9546fb20802fe38ecadd9fe74
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

9.50e-05197544ff19e4c45715752a04541ad6a0cdf5454c9daaa2
ToppCellFibroblasts-HLA-DRA_high_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SSC5D CD248 ADAMTS1 C1RL

9.69e-05198544e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

9.69e-051985447896f9fb89822e8628fe0b90a489c4760c7b876c
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 SLC16A11 MUC5AC

9.69e-05198544778fee7020c82d11ff3984a8e482a23e5d58165f
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Club|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

FCGBP KLK12 SLC16A11 MUC5AC

9.88e-05199544111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK15 FCGBP KLK12 IHH

9.88e-05199544fb9550bbb1fa206c3132e0a21a646eedb41c281a
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FCGBP KLK12 SLC16A11 MUC5AC

9.88e-05199544d583290a1d288b749ad17bc501c1487268c6551c
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK15 FCGBP KLK12 IHH

9.88e-05199544440f47e320c75f49ef47139b46962de68cee8320
ToppCell11.5-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

SSC5D NAT14 ADAMTS1 PDGFC

9.88e-051995441a8c77d241bd817a195e1532fd25f51358cb1ff1
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SSC5D ADAMTS1 ADAMTS13 CNTLN

9.88e-0519954438cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

FCGBP KLK12 SLC16A11 MUC5AC

9.88e-051995442b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

SSC5D ADAMTS1 CNTLN PDGFC

1.01e-04200544593bf6a7c557437db9a9249a5058a46014179ef6
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SHROOM1 THSD7A TIE1 ADAMTS1

1.01e-04200544ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-Neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

THSD7A ATP9A PDGFC RPS6KL1

1.01e-04200544ddac952ad1d46021c2d17d816de9bc31730a0941
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SSC5D ADAMTS1 ADAMTS13 CNTLN

1.01e-0420054409537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

THSD7A ATP9A PDGFC RPS6KL1

1.01e-0420054409fd3cb31bcc02444f1045f01fe39bce09359d35
ToppCellControl-B_naive-4|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SSC5D FCGBP ADAMTS13

2.73e-041045435f72aa686b0fb83d401621e1b9d9c69e56105570
ToppCellControl-B_naive-4|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SSC5D FCGBP ADAMTS13

3.76e-0411654335d471c8dbf408d0be3837c428d9c2a73c805a6f
ToppCellCOVID-19_Severe-Classical_Monocyte-|Classical_Monocyte / Disease condition and Cell class

ADAMTS1 PRSS21 CPOX

5.99e-04136543e272d11bb52f890f6681cc9384aeac27976ec650
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

KLK15 FCGBP KLK12

6.25e-04138543e1e936ff4080bda2810c5fd1154a706359f377a5
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPR153 ZFYVE19 PDGFC

6.38e-041395432fb51abb3ce88c21726c026d6365b2582e2e79f6
ToppCellCOVID-19_Severe-Classical_Monocyte-|COVID-19_Severe / Disease condition and Cell class

ADAMTS1 PRSS21 CPOX

6.51e-04140543cade44740dd3acca7789591aa5a7935d48d5cbee
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SSC4D TIE1 TXNRD3

6.93e-04143543ce045ec7c311a1797ae562bec114f9e90604d063
ToppCellClub_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

KLK12 ADAMTS13 MUC5AC

7.80e-0414954381c813588bb5efb7b31141a75d387210dcb76094
ToppCellsevere_influenza-NK_CD56bright|World / disease group, cell group and cell class (v2)

TIE1 ADAMTS1 GPR153

8.58e-04154543187b9d4eb0e98c506034735601ead480ff00bd57
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

8.74e-0415554362b59cb32b12bd55b19e98786a866d788fc9e4bf
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

IFFO2 SCART1 ADAMTS13

8.74e-0415554383430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCell10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-LMPP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

WDR97 PRSS36 IL27RA

8.91e-04156543331b63bf4744ab494c3959436a8a0d8a1e4c0de4
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-5|TCGA-Colorectal / Sample_Type by Project: Shred V9

FCGBP KLK12 MUC5AC

9.07e-041575435fb41af247465aa29aa7b8edd26e3d3794766f80
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM1 ADAMTS1 ADAMTS13

9.07e-04157543f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCellCOVID-19_Severe-NK_CD56bright|COVID-19_Severe / disease group, cell group and cell class

CELSR3 TIE1 ADAMTS1

9.41e-041595439e2067f0d76769717f7048dab505fadd36bbb83e
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SSC5D THSD7A TIE1

9.58e-04160543c61869d9dbba250270e59366e15af204e5b4395d
ToppCellNS-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SSC5D TIE1 GPR150

9.58e-041605438a4746463ca1976f7d6de803496c851249ced797
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D ADAMTS1 MUC5AC

9.76e-04161543b19f82dd98a3064581793711bb70373f18abecd9
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CELSR3 TXNRD3 UBOX5

9.93e-04162543ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

SHROOM1 SLC16A11 SIRT5

9.93e-04162543a957c7e347189b72fbd47db3075bb5e879a21c67
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

SSC4D DSC2 PRSS21

9.93e-041625437d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLC16A11 RPS6KL1 PRSS36

1.03e-031645434ade97931ae1780af7836d988fe117a10b3e88a1
ToppCell3'_v3-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

LINC01599 COQ3 RPS6KL1

1.03e-031645437766900740f67dbbe3c4d90fbfdcc1665cee6515
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FCGBP SLC16A11 MUC5AC

1.05e-03165543baff639a7046fb5cacb70f341b6d24cef3519f8e
ToppCellClub-club-12|World / Class top

FCGBP SLC16A11 MUC5AC

1.05e-031655439b7a31cbdcd2f96b8bd08a4cd4141b92bd5e9062
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FCGBP SLC16A11 MUC5AC

1.05e-031655436fdce8b23736409a23884ef3918638ffc067a86f
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D THSD7A MUC5AC

1.05e-03165543f80665b75d43f1bf6919d59fc762e7e0bac653f2
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FCGBP SLC16A11 MUC5AC

1.05e-03165543dd4d36ff8efb89fee1fb4c48d1b8f46902119909
ToppCellLPS-antiTNF-Endothelial-Mes-Like-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM1 COQ3 PRSS36

1.07e-0316654394a00edf66d54bc5f7343daea700ca26cf38fd90
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1D THSD7A TIE1

1.08e-03167543774f3264318b002d0df5d06d41d645366038d0bf
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

1.10e-03168543b275e951ff7109e36da22fc17bd4516f9b9432c4
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

1.10e-031685430757a5af953901a8faed5774ffec4755fc9c0a6e
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

1.10e-03168543a0dbe2ee697e29b32aa5f8326445e067ff66c154
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIE1 GPR150 RPS6KL1

1.12e-03169543f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

1.12e-03169543db73dae011ff3749b3706e50ab46d03b775dd6bb
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

1.12e-0316954397b7047b87ce0052d8580565c9b44fd2aa6f0d5c
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

1.12e-031695431a684471dbda42e1470e5a889648666e14f25982
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIE1 GPR150 IL27RA

1.14e-0317054335e3945d8a540a3e2cec1b559316265aaad023d1
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FCGBP DSC2 IHH

1.14e-031705439bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCellsevere-Myeloid-Eosinophils|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CACNA1D THSD7A PRSS21

1.14e-03170543863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GPR153 COQ8B

1.14e-031705438465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIE1 GPR150 IL27RA

1.14e-031705430ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FCGBP DSC2 IHH

1.14e-031705432c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WDR97 TXNRD3 SLC16A11

1.14e-03170543fed8e982d2ce234c59d4016432ed8941df36df27
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIE1 GPR150 IL27RA

1.14e-031705430b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM1 MUC5AC PRSS36

1.16e-0317154359b9dbaa05b6e5740edc633c9ce1181565550d5b
ToppCelldroplet-Lung-nan-21m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC2 GPR150 IFFO2

1.16e-03171543159ce6d5513008532dd7785b915b3fe7440cc4b2
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM1 MUC5AC PRSS36

1.16e-03171543a5b9dd2b6a54db7962beeb5a9ceb9dacfb613fa7
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ADAMTS1 MIB2 ADAMTS13

1.18e-0317254368fd03f2c8ee01fe46194400f74ede3830e00f34
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

FCGBP MUC5AC RPS6KL1

1.18e-03172543f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGBP GPR153 ATP9A

1.18e-03172543e3a8891694343b6b01e80a200ae338d24797e417
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TIE1 SLC16A11 PDGFC

1.18e-031725431bad7b19724e1b53ace7e05644215334c9f43910
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFC RPS6KL1 IL27RA

1.20e-03173543c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DHX58 IFFO2 IL27RA

1.20e-031735431bf9c91c1803a540b5e43bc4280aab4289341cee
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHX58 CD248 SLC16A11

1.20e-031735432acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGBP KLK12 MUC5AC

1.20e-03173543e4d9a9a781acc531bc81c3fcee24d637e805c8e1
ToppCell3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TIE1 SLC16A11 PDGFC

1.20e-0317354385083b9ce20351dd69aa2327ad087b848b4307ff
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHX58 CD248 SLC16A11

1.20e-031735432415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell(00)_Basal-(1)_24hpi|(00)_Basal / shred by cell type and Timepoint

ADAMTS1 PKM IFFO2

1.20e-03173543a8e62e7d8baf6af691acd5c50deedbadc119ceba
ToppCellBasal_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DSC2 TXNRD3 ZNF692

1.22e-03174543a0060be3940043015dcc49a5157de5541aed24a1
ToppCell(03)_Secretory-(0)_uninjured|(03)_Secretory / shred by cell type and Timepoint

FCGBP C1RL SLC16A11

1.22e-03174543ebdddb5091afcc49ab533c890f260f709880c5f9
DrugCK1 inhibitor

VRK1 CSNK1D CSNK1E

1.83e-0611523CID006419753
Diseasesyndromic X-linked intellectual disability Najm type (implicated_via_orthology)

CSNK1D CSNK1E

6.12e-057512DOID:0060807 (implicated_via_orthology)
Diseasetyrosine-protein kinase receptor Tie-1, soluble measurement

TIE1 ADAMTS13

2.26e-0413512EFO_0008312
Diseaseanorexia nervosa

THSD7A CELSR3 CNTLN

2.45e-0470513MONDO_0005351
Diseasepolymyositis

THSD7A DGKQ

5.46e-0420512EFO_0003063
Diseasecomplement factor H-like 1 protein measurement

KLK15 THSD7A

6.62e-0422512EFO_0600092
Diseaseforced expiratory volume

CACNA1D SSC5D NAT14 THSD7A CNTLN CPOX

2.32e-03789516EFO_0004314
Diseasefibroblast growth factor 23 measurement

MCHR2 ADAMTS13

2.53e-0343512EFO_0009381
DiseaseGastrointestinal Stromal Sarcoma

C2CD3 IHH

3.01e-0347512C3179349
DiseaseGastrointestinal Stromal Tumors

C2CD3 IHH

3.40e-0350512C0238198
Diseaselung adenocarcinoma

SSC5D CNTLN PDGFC

3.41e-03174513EFO_0000571
Diseaseglucose metabolism measurement, age-related hearing impairment

THSD7A ATP9A

3.68e-0352512EFO_0005782, EFO_0009367
Diseasesystemic scleroderma (is_marker_for)

ADAMTS13 IL27RA

3.81e-0353512DOID:418 (is_marker_for)
Diseasehair morphology measurement

THSD7A CPOX

3.96e-0354512EFO_0007821

Protein segments in the cluster

PeptideGeneStartEntry
IWVGEEGSGGRRGPG

CNTLN

56

Q9NXG0
VGWSRAGPLCLGTGC

CD248

221

Q9HCU0
GGWFLRVLGPGGCNT

COQ3

11

Q9NZJ6
VLVCGGDGTVGWVLG

DGKQ

641

P52824
VDPRIGGGGVQLGKW

DSC2

681

Q02487
TVRGCWAGPCVGQGT

ADAMTS13

1121

Q76LX8
ALGRGGTVPVGVWGG

ZFYVE19

26

Q96K21
GTVPVGVWGGAGQGR

ZFYVE19

31

Q96K21
GPWGDCSRTCGGGVQ

ADAMTS1

566

Q9UHI8
DGTILGRWCGSGTVP

PDGFC

116

Q9NRA1
VGLVPVVGGEESWGG

SLC16A11

326

Q8NCK7
WGSVGPCGQDGIPGV

KLK12

216

Q9UKR0
GPWVAVRGSGDVCGV

NAT14

96

Q8WUY8
GPLVCGGILQGIVSW

KLK15

211

Q9H2R5
GGILQGIVSWGDVPC

KLK15

216

Q9H2R5
GGVGIPTIRWCGAEG

CSNK1D

61

P48730
RGRGDWSVGAPGGVQ

FUBP3

341

Q96I24
RLPGSAVGWLVCGGL

GPR153

6

Q6NV75
VWVSGNLCGTPGGEE

IL27RA

236

Q6UWB1
GDVVIVLTGWRPGSG

PKM

506

P14618
GVQLGGWRDGVCTKP

MUC5AC

686

P98088
CGGGEARPRTVWLGH

ATP9A

31

O75110
GDSGGPLVCEEGGRW

PRSS36

241

Q5K4E3
GGEWVFGGPLCTIIT

MCHR2

96

Q969V1
GLVPGGGVQFEIWCR

C2CD3

1101

Q4AC94
GRGQWVGEETGPVGG

LINC01599

251

Q8WXQ3
GGKPAGWQVGGAQGC

FCGBP

2226

Q9Y6R7
VATGIVSWGIGCGEG

C1RL

451

Q9NZP8
PGGVISCRNCGEVWG

DHX58

606

Q96C10
GTGGQLGQTVGWPCG

COQ8B

11

Q96D53
GGGGVETVQGPGVSW

IFFO2

171

Q5TF58
GLVGCIQGVWLGSTP

CELSR3

1911

Q9NYQ7
QLGGGCGWRTAVAPA

FAM87A

36

P0C7U9
CGGPRAWSQCGGGGL

CPOX

21

P36551
TECRSGWVGPNGGIT

CACNA1D

331

Q01668
VVPAAWGCGPGRVVG

IHH

21

Q14623
GGEGKPGRVVDIRGW

MIB2

176

Q96AX9
TGGGIPCIKRLEVWG

UBOX5

181

O94941
GSCPQGWVLVEGTGE

SSPOP

2006

A2VEC9
GDECGPGGIQTRAVW

THSD7A

71

Q9UPZ6
TTVLCRLCGGGGPWA

GPR150

61

Q8NGU9
VLGSWGGSGGTIPIV

SHROOM1

311

Q2M3G4
GAGPIWLDDVGCVGT

SSC5D

526

A1L4H1
GPCRGRVEVLHAGGW

SSC4D

351

Q8WTU2
IVRGCGAGRWGPGCT

TIE1

211

P35590
VLGPLGAVGRFVGWG

WDR97

156

A6NE52
FGPGSGPVWLDEVGC

SCART1

841

Q4G0T1
TWVPEGAGPVLGGCG

RPS6KL1

346

Q9Y6S9
SVRAVAVWGIGTPGG

WDR6

776

Q9NNW5
EWKVGLPIGQGGFGC

VRK1

36

Q99986
SWGLGGTCVNVGCIP

TXNRD3

196

Q86VQ6
VSWGVGCGRPNRPGV

PRSS21

256

Q9Y6M0
GCGGLLRPHVVWFGE

SIRT5

211

Q9NXA8
RGPGGQDGGLVWECS

ZNF692

101

Q9BU19
GGVGIPSIKWCGAEG

CSNK1E

61

P49674
SAGVWGQEGPELCGV

KMT2D

146

O14686