Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	AMOP	MUC4 SUSD2	2.81e-05	4	41	2	SM00723
Domain	AMOP	MUC4 SUSD2	2.81e-05	4	41	2	PF03782
Domain	AMOP_dom	MUC4 SUSD2	2.81e-05	4	41	2	IPR005533
Domain	AMOP	MUC4 SUSD2	2.81e-05	4	41	2	PS50856
Domain	GLYCOSYL_HYDROL_F31_2	GANAB MYORG	4.68e-05	5	41	2	PS00707
Domain	CPSASE_1	CPS1 ACACB	4.68e-05	5	41	2	PS00866
Domain	CPSASE_2	CPS1 ACACB	7.01e-05	6	41	2	PS00867
Domain	Glyco_hydro_31	GANAB MYORG	9.81e-05	7	41	2	IPR000322
Domain	CPSase_L_D2	CPS1 ACACB	9.81e-05	7	41	2	PF02786
Domain	Glyco_hydro_31	GANAB MYORG	9.81e-05	7	41	2	PF01055
Domain	CbamoylP_synth_lsu-like_ATP-bd	CPS1 ACACB	9.81e-05	7	41	2	IPR005479
Domain	BC-like_N	CPS1 ACACB	9.81e-05	7	41	2	IPR005481
Domain	Biotin_carb_N	CPS1 ACACB	9.81e-05	7	41	2	PF00289
Domain	GLYCOSYL_HYDROL_F31_1	GANAB MYORG	9.81e-05	7	41	2	PS00129
Domain	-	CPS1 ACACB	3.61e-04	13	41	2	3.40.50.20
Domain	ATP-grasp	CPS1 ACACB	4.21e-04	14	41	2	IPR011761
Domain	PreATP-grasp_dom	CPS1 ACACB	4.21e-04	14	41	2	IPR016185
Domain	ATP_GRASP	CPS1 ACACB	4.21e-04	14	41	2	PS50975
Domain	-	CPS1 ACACB	4.85e-04	15	41	2	3.30.1490.20
Domain	USP_1	USP18 USP54 USP32	4.85e-04	70	41	3	PS00972
Domain	UCH	USP18 USP54 USP32	5.06e-04	71	41	3	PF00443
Domain	USP_2	USP18 USP54 USP32	5.06e-04	71	41	3	PS00973
Domain	USP_3	USP18 USP54 USP32	5.27e-04	72	41	3	PS50235
Domain	USP_dom	USP18 USP54 USP32	5.27e-04	72	41	3	IPR028889
Domain	Peptidase_C19_UCH	USP18 USP54 USP32	5.27e-04	72	41	3	IPR001394
Domain	VWD	MUC4 SUSD2	5.53e-04	16	41	2	SM00216
Domain	VWF_type-D	MUC4 SUSD2	5.53e-04	16	41	2	IPR001846
Domain	VWFD	MUC4 SUSD2	5.53e-04	16	41	2	PS51233
Domain	VWD	MUC4 SUSD2	5.53e-04	16	41	2	PF00094
Domain	ATP_grasp_subdomain_1	CPS1 ACACB	7.04e-04	18	41	2	IPR013815
Domain	-	CPS1 ACACB	7.04e-04	18	41	2	3.30.470.20
Domain	ATP_grasp_subdomain_2	CPS1 ACACB	2.10e-03	31	41	2	IPR013816
Pubmed	Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.	BLM SUPV3L1	4.06e-06	3	41	2	17961633
Pubmed	Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.	PDGFRA PIEZO1	8.12e-06	4	41	2	32385276
Pubmed	Oligodendrocyte precursors guide interneuron migration by unidirectional contact repulsion.	PDGFRA L1CAM	1.35e-05	5	41	2	35587969
Pubmed	Expression patterns of Piezo1 in the developing mouse forebrain.	PDGFRA PIEZO1	1.35e-05	5	41	2	38411929
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BLM TRANK1 ACACB QARS1 MUC4 USP32	2.43e-05	497	41	6	36774506
Pubmed	Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.	USP54 USP32	4.86e-05	9	41	2	37149635
Pubmed	Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.	MUC4 L1CAM	7.41e-05	11	41	2	25315821
Pubmed	Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia.	SRP72 GANAB STXBP2	7.88e-05	70	41	3	35008187
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	USP54 SETD1B STXBP2 GNL1 SUPV3L1	1.30e-04	419	41	5	33001583
Pubmed	MEK Is a Key Regulator of Gliogenesis in the Developing Brain.	PDGFRA L1CAM	3.68e-04	24	41	2	22998872
Pubmed	Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells.	PDGFRA L1CAM	3.68e-04	24	41	2	30348676
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	SRP72 TNS2 ISYNA1 PSME4	4.49e-04	304	41	4	32235678
Pubmed	Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression.	AEN PDGFRA	5.78e-04	30	41	2	34974536
Pubmed	The layered structure of human mitochondrial DNA nucleoids.	CPS1 SUPV3L1	6.58e-04	32	41	2	18063578
Pubmed	Murine txk: a protein tyrosine kinase gene regulated by T cell activation.	TIE1 PDGFRA	6.58e-04	32	41	2	7542761
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	BLM USP54 USP32	7.01e-04	147	41	3	29576527
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	B3GALT1 GANAB	8.80e-04	37	41	2	2542563
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	B3GALT1 GANAB	8.80e-04	37	41	2	2541446
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	B3GALT1 GANAB	9.28e-04	38	41	2	2829950
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	B3GALT1 GANAB	9.28e-04	38	41	2	2187500
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ANTXR1 SRP72 RC3H2 PSME4 SUPV3L1	9.65e-04	650	41	5	38777146
Cytoband	Ensembl 112 genes in cytogenetic band chr15q26	BLM AEN SYNM	8.98e-04	206	42	3	chr15q26
Cytoband	15q26.1	BLM AEN	1.13e-03	54	42	2	15q26.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4q12	SRP72 PDGFRA	2.72e-03	84	42	2	chr4q12
GeneFamily	Ubiquitin specific peptidases	USP18 USP54 USP32	4.77e-05	56	23	3	366
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TIE1 PDGFRA	1.17e-03	40	23	2	321
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SRP72 TRANK1	9.30e-03	115	23	2	769
GeneFamily	Fibronectin type III domain containing	TIE1 L1CAM	1.74e-02	160	23	2	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PDGFRA L1CAM	1.76e-02	161	23	2	593
Coexpression	GSE26928_EFF_MEMORY_VS_CXCR5_POS_CD4_TCELL_UP	B3GALT1 ANTXR1 IRF4 MUC4 SUSD2	1.02e-05	190	40	5	M4686
Coexpression	GSE21670_STAT3_KO_VS_WT_CD4_TCELL_TGFB_TREATED_DN	B3GALT1 AEN USP54 STARD8 AGBL5	1.27e-05	199	40	5	M7443
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNS2 ISYNA1 PDGFRA SUSD2	2.52e-05	181	42	4	6d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPOLB ISYNA1 TIE1 SYNM	2.80e-05	186	42	4	9579180db2a0bf3f043b4d169f9a08cdc45b459a
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANTXR1 TNS2 ISYNA1 PDGFRA	2.86e-05	187	42	4	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANTXR1 TNS2 ISYNA1 PDGFRA	2.86e-05	187	42	4	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ISYNA1 TIE1 SYNM PIEZO1	2.86e-05	187	42	4	55aad84b992412e487a32f4970620189a7380ba6
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANTXR1 TNS2 ISYNA1 PDGFRA	2.86e-05	187	42	4	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPOLB ISYNA1 TIE1 SYNM	2.92e-05	188	42	4	524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell	5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPOLB ISYNA1 TIE1 SYNM	2.92e-05	188	42	4	d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	TRAPPC10 SRP72 GANAB USP32	3.23e-05	193	42	4	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 STARD8 TIE1 SYNM	3.50e-05	197	42	4	407231542fa1ffd540dcb61435c0575e71f59725
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANTXR1 ISYNA1 CPS1 SYNM	3.50e-05	197	42	4	470e23dee4ca35e1fd021b7cdd58fcbc90639837
Disease	hereditary lymphedema (is_implicated_in)	TIE1 PIEZO1	3.75e-05	7	40	2	DOID:0050580 (is_implicated_in)
Disease	pancreatic cancer (is_implicated_in)	PDGFRA MUC4 L1CAM	4.75e-04	112	40	3	DOID:1793 (is_implicated_in)
Disease	clonal hematopoiesis mutation measurement	ISYNA1 STXBP2	2.54e-03	55	40	2	EFO_0020949

Protein segments in the cluster

Peptide	Gene	Start	Entry
YIRPEMPIADYRTRW	AEN	146	Q8WTP8
MAPFVRTLPTRPRWE	AGBL5	106	Q8NDL9
NMRRPSSPRKWYSPI	ANTXR1	436	Q9H6X2
GPIRDVRSKWYMPRD	B3GALT1	211	Q9Y5Z6
YEWREPGMRAPPNTT	CCER1	176	Q8TC90
YAPVYDSRRIWRPPM	RC3H2	691	Q9HBD1
DSRRIWRPPMYQRDD	RC3H2	696	Q9HBD1
WPHMEALRPRPSVYI	ISYNA1	166	Q9NPH2
FLPSRAPYDPRWMLA	ACACB	2036	O00763
WDPRVNPSDRYHLMP	PAPOLB	301	Q9NRJ5
DPMQLPYDSRWEFPR	PDGFRA	576	P16234
MSQPVWERYRPDRFL	MUC4	4521	Q99102
MPPLDRSWRDYVPDQ	IRF4	171	Q15306
WLRPSGPMPADRVTY	L1CAM	276	P32004
VLDFPRRPPWSYEMS	GNL1	126	P36915
PMFSWPRLRDADPIL	CPS1	1311	P31327
SLWRYRPDSLDGPME	BLM	426	P54132
IEPPRESFNRWMLER	PCIF1	226	Q9H4Z3
EWSDRPLREFLTYPM	DOCK4	1231	Q8N1I0
ELEPPMPTWRSRRED	FAM98C	321	Q17RN3
LPSPWRDRPMEESLL	QARS1	371	P47897
LWAPDCPRYMQRRPS	SUSD2	421	Q9UGT4
PSEVWRTERMSYEGP	SYNM	1131	O15061
WDPSRFPQPRTMLER	GANAB	441	Q14697
EYMELAKSRGPWRRP	SETD1B	1631	Q9UPS6
RIPPNWYPDARAMQR	SUPV3L1	186	Q8IYB8
TPDPERWLPMRERSY	SRP72	571	O76094
LFPMDPRWDREERVS	TEX45	66	Q8NA69
RVELWSRAMYPDLGP	STARD8	321	Q92502
APMPPDHFYRRLWER	RIOX1	211	Q9H6W3
MRQCWRDRPYERPPF	TIE1	1086	P35590
EPRERMEPTYQLSRW	STXBP2	461	Q15833
ERLPQPLYERSPMGW	TMDD1	201	P0DPE3
PRSSVDRPRDWYRRM	SORBS3	136	O60504
PWRPLYDMVERILYS	PSME4	141	Q14997
MRPEGSLTYWVPERL	TSPY8	1	P0CW00
MKREQPRERPRAWDY	USP18	36	Q9UMW8
RYVWAMDLRPELPTT	PIEZO1	481	Q92508
LPREPMEWRRSYGRA	TRAPPC10	41	P48553
MWDPRAARVPPRDLA	TRANK1	1	O15050
PRSFSLDPLMERRWD	TNS2	116	Q63HR2
GRDYEMVPEPVWRAL	USP32	556	Q8NFA0
PRRVDMPPDDDWRQS	USP54	1631	Q70EL1
PDPSVWSRRYTEMAL	MYORG	481	Q6NSJ0