Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR18 OR13C8 OR5AN1 OR2C3 OR1E2 TAS2R45 OR7A2P OR10J1 OR14A16 ADGRA3	2.77e-04	884	60	10	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR13C8 OR5AN1 OR2C3 OR1E2 OR7A2P OR10J1 OR14A16	2.99e-04	431	60	7	GO:0004984
Domain	-	KDM5B MEX3A TRIM25 USP51 MTF2 NSD2 MEX3B MEX3C	8.97e-05	449	60	8	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KDM5B MEX3A TRIM25 USP51 MTF2 NSD2 MEX3B MEX3C	1.04e-04	459	60	8	IPR013083
Domain	KH_1	MEX3A MEX3B MEX3C	2.45e-04	38	60	3	PF00013
Domain	-	MEX3A MEX3B MEX3C	2.65e-04	39	60	3	3.30.1370.10
Domain	KH	MEX3A MEX3B MEX3C	2.86e-04	40	60	3	SM00322
Domain	KH_dom	MEX3A MEX3B MEX3C	2.86e-04	40	60	3	IPR004087
Domain	KH_TYPE_1	MEX3A MEX3B MEX3C	3.31e-04	42	60	3	PS50084
Domain	KH_dom_type_1	MEX3A MEX3B MEX3C	3.80e-04	44	60	3	IPR004088
Domain	Zinc_finger_PHD-type_CS	KDM5B MTF2 NSD2	1.19e-03	65	60	3	IPR019786
Domain	Olfact_rcpt	OR13C8 OR5AN1 OR2C3 OR1E2 OR10J1 OR14A16	1.60e-03	393	60	6	IPR000725
Domain	PRAME_family	PRAMEF7 PRAMEF8	1.68e-03	19	60	2	IPR026271
Domain	PHD	KDM5B MTF2 NSD2	1.81e-03	75	60	3	PF00628
Domain	Znf_PHD-finger	KDM5B MTF2 NSD2	2.10e-03	79	60	3	IPR019787
Domain	PHD	KDM5B MTF2 NSD2	2.94e-03	89	60	3	SM00249
Domain	RING	MEX3A TRIM25 NSD2 MEX3B MEX3C	2.95e-03	305	60	5	SM00184
Domain	Znf_PHD	KDM5B MTF2 NSD2	3.13e-03	91	60	3	IPR001965
Domain	ZF_PHD_2	KDM5B MTF2 NSD2	3.54e-03	95	60	3	PS50016
Domain	ZF_PHD_1	KDM5B MTF2 NSD2	3.64e-03	96	60	3	PS01359
Domain	Znf_RING	MEX3A TRIM25 NSD2 MEX3B MEX3C	3.91e-03	326	60	5	IPR001841
Domain	GPCR_Rhodpsn_7TM	GPR18 OR13C8 OR5AN1 OR2C3 OR1E2 OR10J1 OR14A16	5.50e-03	670	60	7	IPR017452
Domain	7tm_1	GPR18 OR13C8 OR5AN1 OR2C3 OR1E2 OR10J1 OR14A16	5.81e-03	677	60	7	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR18 OR13C8 OR5AN1 OR2C3 OR1E2 OR10J1 OR14A16	6.19e-03	685	60	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR18 OR13C8 OR5AN1 OR2C3 OR1E2 OR10J1 OR14A16	6.49e-03	691	60	7	PS50262
Domain	GPCR_Rhodpsn	GPR18 OR13C8 OR5AN1 OR2C3 OR1E2 OR10J1 OR14A16	6.54e-03	692	60	7	IPR000276
Pathway	REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA	CYLD TRIM25 DHX58 NLRC5	9.14e-05	82	41	4	M1002
Pathway	REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING	CYLD TRIM25 NLRC5	1.40e-04	35	41	3	M985
Pubmed	CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness.	MEX3A MEX3B MEX3C	2.26e-08	4	63	3	23408853
Pubmed	Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.	MEX3A MEX3B MEX3C	1.13e-07	6	63	3	17267406
Pubmed	Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules.	MEX3A MEX3B MEX3C	1.23e-06	12	63	3	18779327
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CYLD FSIP2 KDM5B PI4KA PCDH7 MEX3B EDRF1 MEX3C DOP1A OTOG	3.20e-06	861	63	10	36931259
Pubmed	RNA Helicase LGP2 Negatively Regulates RIG-I Signaling by Preventing TRIM25-Mediated Caspase Activation and Recruitment Domain Ubiquitination.	TRIM25 DHX58	9.68e-06	3	63	2	31237466
Pubmed	Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.	NSD2 NLRC5	9.68e-06	3	63	2	35230972
Pubmed	Pooled genetic analysis identifies variants that confer enhanced susceptibility to PCOS in Indian ethnicity.	THADA IDE	9.68e-06	3	63	2	32416252
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR13C8 OR2C3 OR1E2 OR7A2P OR10J1	4.94e-05	219	63	5	12213199
Pubmed	The human olfactory receptor gene family.	OR13C8 OR5AN1 OR2C3 OR1E2 OR7A2P OR10J1 OR14A16	5.52e-05	541	63	7	14983052
Pubmed	Sensitivity-dependent hierarchical receptor codes for odors.	OR5AN1 OR1E2	1.15e-04	9	63	2	12588732
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	THADA NSD2 PI4KA ARFGEF2 NLRC5 CFAP43 SLC45A1 SLC29A2 TOP3B	1.62e-04	1105	63	9	35748872
Pubmed	Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.	OR5AN1 OR1E2	1.76e-04	11	63	2	26361056
Pubmed	Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.	TRIM25 DHX58	2.11e-04	12	63	2	33373584
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR1E2 OR7A2P	2.49e-04	13	63	2	11014824
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	FSIP2 MEX3A MEX3B MEX3C	2.51e-04	168	63	4	30631154
Pubmed	Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.	WRNIP1 AKAP8L	3.34e-04	15	63	2	24726327
Pubmed	Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.	FANCD2 KPNB1	3.34e-04	15	63	2	20603015
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	MEX3A WDR75 NSD2 ZBED6 KPNB1	3.44e-04	332	63	5	37433992
Pubmed	No replication of genetic association between candidate polymorphisms and Alzheimer's disease.	IDE SORL1	3.81e-04	16	63	2	19889475
Pubmed	Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.	IDE SORL1	3.81e-04	16	63	2	20880607
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR13C8 OR5AN1 OR1E2 OR7A2P OR10J1	3.83e-04	340	63	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR13C8 OR5AN1 OR1E2 OR7A2P OR10J1	3.83e-04	340	63	5	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR13C8 OR5AN1 OR1E2 OR7A2P OR10J1	3.99e-04	343	63	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR13C8 OR5AN1 OR1E2 OR7A2P OR10J1	4.15e-04	346	63	5	14611657
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF8	4.32e-04	17	63	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF8	4.32e-04	17	63	2	37781892
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MEX3A TRIM25 WRNIP1 MEX3B MEX3C	4.84e-04	358	63	5	32460013
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF8	4.85e-04	18	63	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF8	4.85e-04	18	63	2	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF8	4.85e-04	18	63	2	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF8	4.85e-04	18	63	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF8	4.85e-04	18	63	2	39181896
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	TRIM25 PI4KA ARFGEF2 TOP3B	5.03e-04	202	63	4	33005030
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CYLD THADA DENND6A ZBED6 PI4KA ARFGEF2 PCDH7	5.05e-04	777	63	7	35844135
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF8	5.41e-04	19	63	2	28604677
Pubmed	Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.	THADA IDE	5.41e-04	19	63	2	19139842
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	FANCD2 NSD2 PI4KA IDE PCDH7 TOP3B AKAP8L KPNB1	5.95e-04	1049	63	8	27880917
Pubmed	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.	THADA IDE	6.01e-04	20	63	2	19862325
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF8	6.01e-04	20	63	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF8	6.01e-04	20	63	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF8	6.01e-04	20	63	2	21425410
Pubmed	Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.	THADA IDE	6.01e-04	20	63	2	19933996
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	MEX3A WDR75 TOP3B MEX3B AKAP8L MEX3C KPNB1	6.32e-04	807	63	7	22681889
Pubmed	Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.	THADA IDE	6.63e-04	21	63	2	18591388
Pubmed	Underlying genetic models of inheritance in established type 2 diabetes associations.	THADA IDE	6.63e-04	21	63	2	19602701
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	MEX3A TRIM25 MEX3C	6.96e-04	95	63	3	29643511
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF8	7.29e-04	22	63	2	31729367
Pubmed	Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.	THADA IDE	7.29e-04	22	63	2	19794065
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR1E2 OR7A2P	7.97e-04	23	63	2	10706615
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF8	7.97e-04	23	63	2	19480014
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR1E2 OR7A2P	8.69e-04	24	63	2	9119360
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	FANCD2 CYLD INTS10 THADA NSD2 WRNIP1 AKAP8L SORL1	8.89e-04	1116	63	8	31753913
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF8	9.43e-04	25	63	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF8	9.43e-04	25	63	2	12620990
Pubmed	A whole genome screen for HIV restriction factors.	TRIM25 NLRC5 MEX3B	1.01e-03	108	63	3	22082156
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF8	1.02e-03	26	63	2	18500982
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FANCD2 THADA TRIM25 WDR75 NSD2 PI4KA IDE ADGRA3 KPNB1	1.02e-03	1425	63	9	30948266
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	THADA IDE	1.10e-03	27	63	2	20490451
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CYLD TRIM25 NSD2 PI4KA EDRF1 FAM111B	1.10e-03	645	63	6	25281560
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF8	1.18e-03	28	63	2	25089626
Pubmed	Obesity and diabetes genetic variants associated with gestational weight gain.	THADA IDE	1.27e-03	29	63	2	20816152
Pubmed	Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.	THADA KPNB1	1.27e-03	29	63	2	22190364
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF8	1.36e-03	30	63	2	38786026
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CYLD THADA TRIM25 WDR75 GLG1 PI4KA PCDH7 TOP3B EDRF1	1.38e-03	1487	63	9	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	INTS10 TRIM25 WDR75 NSD2 ZBED6 GLG1 PI4KA AKAP8L EDRF1	1.44e-03	1497	63	9	31527615
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF7 PRAMEF8	1.55e-03	32	63	2	37889087
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	MEX3A TRIM25 DHX58 FAM111B KPNB1	1.61e-03	469	63	5	37314180
Pubmed	Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.	THADA IDE	1.64e-03	33	63	2	20203524
Interaction	IFIH1 interactions	TRIM25 DHX58 NLRC5 IDE	3.53e-06	39	54	4	int:IFIH1
Interaction	SORCS2 interactions	FANCD2 TRIM25 SORL1	1.20e-05	17	54	3	int:SORCS2
Interaction	ABCA13 interactions	FANCD2 TRIM25 ABCA5	2.01e-05	20	54	3	int:ABCA13
Interaction	PROKR1 interactions	FANCD2 THADA PI4KA	2.34e-05	21	54	3	int:PROKR1
Interaction	NLRC5 interactions	NSD2 NLRC5 TOP3B	3.10e-05	23	54	3	int:NLRC5
Interaction	SLC25A45 interactions	FANCD2 MEX3A	4.21e-05	4	54	2	int:SLC25A45
Interaction	AHDC1 interactions	FANCD2 MEX3A TRIM25 TOP3B	4.61e-05	74	54	4	int:AHDC1
Interaction	HAL interactions	FANCD2 CYLD GPR18 TRIM25 PI4KA	4.72e-05	148	54	5	int:HAL
Interaction	PXDN interactions	FANCD2 CYLD MEX3A PATE1	7.58e-05	84	54	4	int:PXDN
Interaction	DNAJA1 interactions	FANCD2 CYLD THADA TRIM25 UBASH3B PCDH7 TOP3B EDRF1	8.10e-05	533	54	8	int:DNAJA1
Interaction	PLEKHA2 interactions	MEX3A TRIM25 EDRF1 KPNB1	1.17e-04	94	54	4	int:PLEKHA2
Interaction	PNPLA2 interactions	TRIM25 ARFGEF2 TOP3B	1.44e-04	38	54	3	int:PNPLA2
Interaction	RUSC2 interactions	TRIM25 MEX3B KPNB1	1.44e-04	38	54	3	int:RUSC2
Interaction	ZNF713 interactions	TRIM25 SORL1	1.47e-04	7	54	2	int:ZNF713
Interaction	CFAP43 interactions	CFAP43 TOP3B	1.47e-04	7	54	2	int:CFAP43
Interaction	FAM131A interactions	MEX3A TRIM25	1.47e-04	7	54	2	int:FAM131A
Interaction	SLC45A1 interactions	SLC45A1 TOP3B	1.47e-04	7	54	2	int:SLC45A1
Interaction	CNOT1 interactions	FANCD2 MEX3A TRIM25 TOP3B MEX3B MEX3C	1.60e-04	305	54	6	int:CNOT1
Interaction	MYOF interactions	CYLD MEX3A TRIM25 TOP3B	1.61e-04	102	54	4	int:MYOF
Interaction	LCN1 interactions	FANCD2 CYLD NSD2 KLHL22	1.80e-04	105	54	4	int:LCN1
Interaction	SERPINB12 interactions	FANCD2 CYLD TRIM25 KPNB1	1.87e-04	106	54	4	int:SERPINB12
Interaction	COMTD1 interactions	FANCD2 THADA TRIM25 TOP3B KPNB1	1.95e-04	200	54	5	int:COMTD1
Interaction	NBPF1 interactions	TRIM25 TOP3B	1.95e-04	8	54	2	int:NBPF1
Interaction	TMEM127 interactions	MEX3A TOP3B	1.95e-04	8	54	2	int:TMEM127
Interaction	RCC1 interactions	FANCD2 MEX3A TRIM25 TOP3B KPNB1	2.00e-04	201	54	5	int:RCC1
Interaction	AHNAK interactions	FANCD2 CYLD MEX3A TRIM25 PCDH7 TOP3B	2.01e-04	318	54	6	int:AHNAK
Interaction	CD244 interactions	CTPS2 PI4KA ARFGEF2	2.08e-04	43	54	3	int:CD244
Interaction	CHPF interactions	FANCD2 TRIM25 TOP3B	2.23e-04	44	54	3	int:CHPF
Interaction	NCCRP1 interactions	FANCD2 CYLD GPR18 PI4KA	2.23e-04	111	54	4	int:NCCRP1
Interaction	MYO9B interactions	FANCD2 MEX3A TRIM25 TOP3B	2.39e-04	113	54	4	int:MYO9B
Interaction	ATAD3A interactions	FANCD2 CYLD TRIM25 NLRC5 TOP3B MEX3C	2.45e-04	330	54	6	int:ATAD3A
Interaction	KTN1 interactions	FANCD2 CYLD CTPS2 TRIM25 SLC16A7 TOP3B	2.50e-04	331	54	6	int:KTN1
Interaction	TNFRSF1A interactions	FANCD2 CYLD THADA TRIM25 MEX3C	2.50e-04	211	54	5	int:TNFRSF1A
Interaction	APLNR interactions	FANCD2 THADA MEX3A CTPS2 PI4KA	2.50e-04	211	54	5	int:APLNR
Interaction	ANKRD33B interactions	TRIM25 TOP3B	2.51e-04	9	54	2	int:ANKRD33B
Interaction	DIP2C interactions	TRIM25 TOP3B	2.51e-04	9	54	2	int:DIP2C
Interaction	ZBED6 interactions	MEX3A ZBED6	2.51e-04	9	54	2	int:ZBED6
Interaction	RNPEPL1 interactions	TRIM25 TOP3B	2.51e-04	9	54	2	int:RNPEPL1
Interaction	ORAI1 interactions	FANCD2 ARFGEF2 TOP3B	2.54e-04	46	54	3	int:ORAI1
Interaction	MEX3D interactions	TOP3B MEX3B MEX3C	2.54e-04	46	54	3	int:MEX3D
Interaction	C3orf18 interactions	THADA PI4KA ARFGEF2 TOP3B	2.55e-04	115	54	4	int:C3orf18
Interaction	ARAP1 interactions	TRIM25 UBASH3B TOP3B	2.71e-04	47	54	3	int:ARAP1
Interaction	FAM98B interactions	FANCD2 CYLD TRIM25 IDE	3.00e-04	120	54	4	int:FAM98B
Interaction	MPP3 interactions	TRIM25 PI4KA TOP3B	3.07e-04	49	54	3	int:MPP3
Interaction	PATE1 interactions	GLG1 PATE1 SORL1	3.07e-04	49	54	3	int:PATE1
Interaction	HMGXB3 interactions	MEX3A TOP3B	3.13e-04	10	54	2	int:HMGXB3
Interaction	MMP17 interactions	TRIM25 TOP3B	3.13e-04	10	54	2	int:MMP17
Interaction	SBNO2 interactions	TRIM25 TOP3B	3.13e-04	10	54	2	int:SBNO2
Interaction	SLC8B1 interactions	TRIM25 TOP3B	3.13e-04	10	54	2	int:SLC8B1
Interaction	DENND6B interactions	DENND6A MEX3A	3.13e-04	10	54	2	int:DENND6B
Interaction	MEX3B interactions	MEX3A TOP3B MEX3B EDRF1 MEX3C	3.16e-04	222	54	5	int:MEX3B
Interaction	CABLES1 interactions	TRIM25 TOP3B MEX3B	3.26e-04	50	54	3	int:CABLES1
Interaction	GTPBP1 interactions	TRIM25 TOP3B MEX3B MEX3C	3.40e-04	124	54	4	int:GTPBP1
Interaction	SPTAN1 interactions	FANCD2 CYLD MEX3A CTPS2 TRIM25 UBASH3B TOP3B	3.41e-04	496	54	7	int:SPTAN1
Interaction	MCRIP2 interactions	TRIM25 TOP3B MEX3B	3.46e-04	51	54	3	int:MCRIP2
Interaction	NLE1 interactions	FANCD2 CTPS2 TRIM25 WRNIP1 TOP3B	3.57e-04	228	54	5	int:NLE1
Interaction	PIK3C2B interactions	CYLD TRIM25 TOP3B	3.66e-04	52	54	3	int:PIK3C2B
Interaction	IGF2BP2 interactions	FANCD2 CYLD MEX3A TRIM25 TOP3B MEX3B	3.74e-04	357	54	6	int:IGF2BP2
Interaction	IGLV6-57 interactions	FANCD2 KLHL22	3.82e-04	11	54	2	int:IGLV6-57
Interaction	ADAT1 interactions	TRIM25 TOP3B	3.82e-04	11	54	2	int:ADAT1
Interaction	LYRM1 interactions	DENND6A IDE	3.82e-04	11	54	2	int:LYRM1
Interaction	TOP3B interactions	THADA TRIM25 NSD2 PI4KA ARFGEF2 NLRC5 CFAP43 SLC45A1 SLC29A2 TOP3B MEX3B AKAP8L	4.20e-04	1470	54	12	int:TOP3B
Interaction	YWHAE interactions	FANCD2 CYLD KDM5B TRIM25 CFAP43 PCDH7 MEX3B MEX3C OTOG KLHL22 KPNB1	4.22e-04	1256	54	11	int:YWHAE
Interaction	KRT6B interactions	FANCD2 CYLD UBASH3B PCDH7	4.32e-04	132	54	4	int:KRT6B
Interaction	FAN1 interactions	FANCD2 WDR75 KPNB1	4.32e-04	55	54	3	int:FAN1
Interaction	RAP1GAP2 interactions	TRIM25 TOP3B	4.57e-04	12	54	2	int:RAP1GAP2
Interaction	PLA2G4B interactions	FANCD2 TOP3B	4.57e-04	12	54	2	int:PLA2G4B
Interaction	SPN interactions	FANCD2 THADA PI4KA	4.80e-04	57	54	3	int:SPN
Interaction	PRKDC interactions	FANCD2 CYLD THADA MEX3A CTPS2 TRIM25 TOP3B MEX3C	4.92e-04	695	54	8	int:PRKDC
Interaction	TRIM56 interactions	CYLD TRIM25 TOP3B MEX3B	4.97e-04	137	54	4	int:TRIM56
Interaction	PABPC1 interactions	FANCD2 CYLD MEX3A TRIM25 PCDH7 TOP3B MEX3B MEX3C	5.11e-04	699	54	8	int:PABPC1
Interaction	SLC2A1 interactions	FANCD2 CYLD CTPS2 TRIM25 TOP3B	5.15e-04	247	54	5	int:SLC2A1
Interaction	NR2F2 interactions	FANCD2 MEX3A TRIM25 TOP3B	5.25e-04	139	54	4	int:NR2F2
Interaction	CACNG4 interactions	CTPS2 PI4KA KPNB1	5.32e-04	59	54	3	int:CACNG4
Interaction	ICE1 interactions	FANCD2 MTF2 TOP3B	5.32e-04	59	54	3	int:ICE1
Interaction	CNOT7 interactions	MEX3A TOP3B MEX3B MEX3C	5.39e-04	140	54	4	int:CNOT7
Interaction	SLC52A2 interactions	TRIM25 TOP3B	5.39e-04	13	54	2	int:SLC52A2
Interaction	TIGD3 interactions	CTPS2 TOP3B	5.39e-04	13	54	2	int:TIGD3
Interaction	PCNX1 interactions	KDM5B TOP3B	5.39e-04	13	54	2	int:PCNX1
Interaction	RPS27A interactions	FANCD2 CYLD FSIP2 TRIM25 NSD2 UBASH3B PCDH7	5.43e-04	536	54	7	int:RPS27A
Interaction	MEX3A interactions	MEX3A WDR75 NSD2 ZBED6 MEX3B KPNB1	5.49e-04	384	54	6	int:MEX3A
Interaction	PFKFB2 interactions	CYLD TRIM25 NSD2	6.15e-04	62	54	3	int:PFKFB2
Interaction	MYL1 interactions	FANCD2 CYLD TRIM25	6.15e-04	62	54	3	int:MYL1
Interaction	SPATA2L interactions	CYLD TRIM25	6.28e-04	14	54	2	int:SPATA2L
Interaction	MYOM3 interactions	FANCD2 TOP3B	6.28e-04	14	54	2	int:MYOM3
Interaction	RTL6 interactions	MEX3A TOP3B	6.28e-04	14	54	2	int:RTL6
Interaction	AZGP1 interactions	FANCD2 CYLD TRIM25 NSD2	6.31e-04	146	54	4	int:AZGP1
Interaction	ABL1 interactions	MEX3A TRIM25 WRNIP1 UBASH3B TOP3B	6.38e-04	259	54	5	int:ABL1
Interaction	PAIP2 interactions	TRIM25 TOP3B MEX3B	6.45e-04	63	54	3	int:PAIP2
Interaction	FPR1 interactions	FANCD2 THADA PI4KA ARFGEF2	6.47e-04	147	54	4	int:FPR1
Interaction	NUP188 interactions	FANCD2 TRIM25 TOP3B KPNB1	6.64e-04	148	54	4	int:NUP188
Interaction	ARG1 interactions	FANCD2 CYLD GPR18 TRIM25	6.81e-04	149	54	4	int:ARG1
Cytoband	1q32.1	KDM5B ZBED6 LINC00862	4.33e-04	108	62	3	1q32.1
GeneFamily	PHD finger proteins	KDM5B MTF2 NSD2	1.65e-03	90	47	3	88
GeneFamily	PRAME family	PRAMEF7 PRAMEF8	1.76e-03	24	47	2	686
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP	THADA DENND6A CTPS2 USP51 UBASH3B ADGRA3	6.58e-06	197	61	6	M7403
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	INTS10 NLRC5 CRTAC1 KPNB1	9.32e-04	224	57	4	EFO_0004574, EFO_0008317
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	INTS10 NLRC5 CRTAC1 KPNB1	9.47e-04	225	57	4	EFO_0008317, EFO_0010351
Disease	non-high density lipoprotein cholesterol measurement	INTS10 THADA ARFGEF2 ZNF90 UBASH3B KPNB1	2.48e-03	713	57	6	EFO_0005689
Disease	deoxycholate measurement	ADGRA3 MEX3C	2.59e-03	39	57	2	EFO_0010475
Disease	stromal cell-derived factor 1 alpha measurement	THADA ADGRA3	3.15e-03	43	57	2	EFO_0008293
Disease	Malignant Head and Neck Neoplasm	FANCD2 CYLD	3.29e-03	44	57	2	C0278996
Disease	monocyte count	THADA MTF2 GLG1 PI4KA NLRC5 UBASH3B OR10J1 SORL1	3.69e-03	1320	57	8	EFO_0005091
Disease	dyslexia	INTS10 ARFGEF2 CRTAC1	3.83e-03	162	57	3	EFO_0005424
Disease	triglycerides to total lipids in medium HDL percentage	INTS10 NLRC5	5.28e-03	56	57	2	EFO_0022333
Disease	cholesteryl esters to total lipids in medium HDL percentage	INTS10 NLRC5	5.28e-03	56	57	2	EFO_0022251
Disease	neutrophil-to-lymphocyte ratio	THADA NLRC5 UBASH3B	5.53e-03	185	57	3	EFO_0008447
Disease	Alzheimer's disease (biomarker_via_orthology)	CHAT IDE	5.65e-03	58	57	2	DOID:10652 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PFCHCTFVIGIAQVM	ABCA5	361	Q8WWZ7
LKCFHIPCVVENFPM	CFAP43	896	Q8NDM7
HMLVNLCFHIFLTCV	ADGRA3	796	Q8IWK6
VLVCFMPFHICFAFL	GPR18	241	Q14330
CNCMLDIFKTTIPHV	ARFGEF2	1471	Q9Y6D5
CQGMFLCAVIRALHQ	DOP1A	1636	Q5JWR5
AHVCVLLQPLVCYMV	CDADC1	186	Q9BWV3
AAHCAACDLFIPMQF	AKAP8L	481	Q9ULX6
FHEACVQCLQKPMLF	MTF2	226	Q9Y483
PHFFCELNEMIHLAC	OR7A2P	176	Q8NGA2
CGENLMVVLHRFCIN	INTS10	686	Q9NVR2
DNLICNVPELVMCFH	EDRF1	356	Q3B7T1
LSCQQHKTDPICMFL	FSIP2	851	Q5CZC0
LPQCQMIFDENECFL	PCDH7	96	O60245
ECLNRMLMFECHPQV	NSD2	1031	O96028
LLCMCPVDFHGIFQL	PI4KA	56	P42356
IMFNGVCHLLCPLAQ	SLC16A7	321	O60669
AAPMIQCELCRDAFH	KDM5B	1186	Q9UGL1
DHFFCEMPLIMQLAC	OR2C3	176	Q8N628
RHFFCDMPQLLILSC	OR5AN1	176	Q8NGI8
SFIHCVCMQLEVPLD	NLRC5	71	Q86WI3
CVLHFQVFLEMPVQF	PCDHB4	101	Q9Y5E5
LLMRACEPIIQNFCH	GLG1	691	Q92896
QIPEIIHFCCDFLMS	KLHL22	131	Q53GT1
PLISFHCMCFNTVLL	LINC00473	136	A8K010
HCMCFNTVLLFPRLF	LINC00473	141	A8K010
QFPVEHVQLLCINCM	DHX58	546	Q96C10
IFRCFCPVFLHSQML	DENND6A	271	Q8IWF6
HFIMQVVCEATQCPD	KPNB1	216	Q14974
HCMDTNECIQFPFVC	CRTAC1	556	Q9NQ79
MFLELFCQIISEPCF	IDE	806	P14735
HGCIPCQNMELFAVL	CYLD	851	Q9NQC7
CENPNMECILFHVVA	FAM111B	176	Q6SJ93
LHVCCKELQVFGMPI	PRAMEF8	176	Q5VWM4
CNMPKALRTLCVNHF	SLC45A1	551	Q9Y2W3
EIVHCVFQLLTPMCN	FANCD2	1011	Q9BXW9
LMARLCFCADNVIPH	OR1E2	171	P47887
HFFCDIRPVMKLSCI	OR10J1	186	P30954
PVIEIVQCRMCHLQF	PATE1	41	Q8WXA2
QQPCVALTVYVAMCH	OTOG	2341	Q6ZRI0
LPFCANNVIKHFVCE	OR13C8	166	Q8NGS7
MVHQFFCDIPQLLAI	OR14A16	171	Q8NHC5
VIAALVPCGHNLFCM	MEX3B	526	Q6ZN04
CTFEHFCDVLDMLIP	GM2A	106	P17900
PLLFLACHLFVVNMN	TAS2R45	136	P59539
CEPLCTHFMDFVCKN	SORL1	1271	Q92673
FLLLAMKENHPECFC	THADA	1591	Q6YHU6
QFFNPICCFLLFNIM	SLC29A2	326	Q14542
VIAALVPCGHNLFCM	MEX3C	616	Q5U5Q3
CHVCGLNLFIFMDPV	LINC00862	26	A6NCI5
PEHVIVACCNQFFVL	CHAT	301	P28329
LHVCCKELQVFGMPI	PRAMEF7	176	Q5VXH5
CVMFEVHELNVLAPF	TMEM244	36	Q5VVB8
QHMGCVFCDPVFQEL	TOP3B	796	O95985
SMFCHVNPEQVICIH	CTPS2	231	Q9NRF8
TCFMNCIVQALTHIP	USP51	371	Q70EK9
AFVCQHSIMALALPC	TNS4	536	Q8IZW8
KINMPHEDCITALCF	WDR75	436	Q8IWA0
LVPCGHNLFCMECAV	MEX3A	481	A1L020
VCMASFCQEHLQPHF	TRIM25	121	Q14258
HFIGMPECEVLLAQC	WRNIP1	566	Q96S55
VPCFLHCLNMVIQDF	ZBED6	581	P86452
VMCFHFAQDLCPEQS	ZNF90	76	Q03938
HNIFPHITLCQFFMC	UBASH3B	121	Q8TF42