Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-19 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.04e-0837856GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-19 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.23e-0838856GO:0070001
GeneOntologyMolecularFunctiontranscription factor binding

BPTF SP1 PPARGC1B SALL1 HIPK2 KCTD1 RUNX2 BSN MEF2C MED13 TFDP2 SMAD4 CRTC2

1.70e-057538513GO:0008134
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

TFEB SP1 USF3 NFYC POU2F1 POU2F2 RUNX2 POU2F3 MEF2C TFDP2 SMAD4

2.50e-055608511GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

TFEB SP1 USF3 NFYC POU2F1 POU2F2 RUNX2 POU2F3 MEF2C TFDP2 SMAD4

2.75e-055668511GO:0001216
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

TFEB BPTF SP1 FOXP4 CPHXL USF3 SALL1 CPHXL2 NFYC POU2F1 POU2F2 RUNX2 ZNF236 RFX7 POU2F3 MEF2C TFDP2 SMAD4

3.44e-0514598518GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

TFEB BPTF SP1 FOXP4 CPHXL SALL1 CPHXL2 NFYC POU2F1 POU2F2 RUNX2 ZNF236 RFX7 POU2F3 MEF2C SMAD4

6.20e-0512448516GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

TFEB BPTF SP1 FOXP4 CPHXL SALL1 CPHXL2 NFYC POU2F1 POU2F2 RUNX2 ZNF236 RFX7 POU2F3 MEF2C SMAD4

8.00e-0512718516GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

TFEB SP1 FOXP4 CPHXL USF3 SALL1 CPHXL2 NFYC POU2F1 POU2F2 RUNX2 ZNF236 RFX7 POU2F3 MEF2C TFDP2 SMAD4

8.01e-0514128517GO:0000981
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2B

4.93e-048852GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2B

7.88e-0410852GO:0140999
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

SP1 PPARGC1B SALL1 HIPK2 RUNX2 MEF2C MED13 SMAD4 CRTC2

8.20e-04582859GO:0140297
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-10

9.61e-0411852GO:0004523
GeneOntologyMolecularFunctionchromatin binding

SALL1 ASXL3 POU2F1 MLLT10 RUNX2 MEF2C DDX11L8 TOP2A SMAD4 CRTC2

1.16e-037398510GO:0003682
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-10

1.58e-0314852GO:0003964
GeneOntologyMolecularFunctiontranscription coactivator activity

KMT2C TSC22D1 PPARGC1B HIPK2 MAML2 MED13

1.86e-03303856GO:0003713
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

SP1 PPARGC1B SALL1 HIPK2 MEF2C MED13 SMAD4

2.01e-03417857GO:0061629
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 ADAMTS17 ERVK-19 ERVK-21 ERVK-9 ERVK-10 ERVK-24

2.38e-03430857GO:0004175
GeneOntologyMolecularFunctiontranscription coregulator activity

KMT2C TSC22D1 PPARGC1B HIPK2 SUPT20HL2 MAML2 KCTD1 MED13

2.70e-03562858GO:0003712
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2B

3.24e-0320852GO:0042800
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-10

3.57e-0321852GO:0035613
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

KMT2C CNKSR1 TSC22D1 PPARGC1B HIPK2 AP1G2 SUPT20HL2 MAML2 KCTD1 WNK1 YTHDF2 MED13

3.61e-0311608512GO:0030674
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

TFEB BPTF SP1 KMT2C TSC22D1 PPARGC1B USF3 SALL1 ASXL3 NFYC HIPK2 POU2F1 POU2F2 SUPT20HL2 POGZ MAML2 MLLT10 RUNX2 RFX7 POU2F3 MEF2C TOP2A MED13 TFDP2 SMAD4 CRTC2

2.92e-1113908526GO:0045944
GeneOntologyBiologicalProcessviral process

ERVK-6 SP1 KIAA0319L ERVK-5 ERVK-19 ERVK-21 ERVK-9 ERVK-10 ERVK-24 POU2F3 TOP2A

3.16e-064648511GO:0016032
GeneOntologyBiologicalProcessembryonic morphogenesis

SP1 FOXP4 SALL1 MTHFR HIPK2 POU2F1 SUPT20HL2 RUNX2 WNK1 MEF2C YTHDF2 SMAD4

3.46e-057138512GO:0048598
GeneOntologyBiologicalProcesspositive regulation of alkaline phosphatase activity

PPARGC1B MEF2C

1.00e-044852GO:0010694
GeneOntologyBiologicalProcessregulation of termination of RNA polymerase II transcription

SCAF8 WNK1

1.00e-044852GO:1904594
GeneOntologyCellularComponentchromatin

TFEB BPTF SP1 FOXP4 SALL1 BICRA NFYC POU2F1 POU2F2 SUPT20HL2 BICRAL POGZ RUNX2 RFX7 POU2F3 MEF2C DDX11L8 TFDP2 SMAD4

4.07e-0614808319GO:0000785
GeneOntologyCellularComponentnuclear protein-containing complex

BPTF KMT2C PPARGC1B R3HCC1L SALL1 KMT2B SCAF8 BICRA ASXL3 NFYC HIPK2 POU2F1 BICRAL NUP58 DDX11L8 MED13 TFDP2 SMAD4

6.00e-0613778318GO:0140513
GeneOntologyCellularComponenttranscription regulator complex

TFEB SP1 SALL1 NFYC HIPK2 POU2F1 RUNX2 POU2F3 TFDP2 SMAD4

1.23e-045968310GO:0005667
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

BPTF SALL1 BICRA BICRAL

5.82e-0496834GO:0070603
GeneOntologyCellularComponentcytoplasmic stress granule

PRRC2C HIPK2 YTHDF2 MOV10

5.82e-0496834GO:0010494
HumanPhenoNarrow palpebral fissure

BICRA KCTD1 RFX7 MED13 SMAD4

1.95e-0571255HP:0045025
HumanPheno2-3 toe syndactyly

SALL1 KMT2B KCTD1 MEF2C SMAD4

6.19e-0590255HP:0004691
HumanPhenoBroad thumb

BPTF SALL1 BICRA POGZ KCTD1

6.19e-0590255HP:0011304
HumanPhenoThick eyebrow

BPTF KMT2C BICRA ASXL3 MEF2C SMAD4

7.62e-05154256HP:0000574
HumanPhenoSyndactyly

SALL1 PNPLA6 KMT2B BICRA KCTD1 CTNND1 RFX7 MEF2C SMAD4

9.44e-05417259HP:0001159
HumanPhenoCutaneous syndactyly

SALL1 BICRA KCTD1 CTNND1 RFX7

1.18e-04103255HP:0012725
HumanPhenoAbnormal finger morphology

BPTF KMT2C SALL1 PNPLA6 KMT2B BICRA ASXL3 ADAMTS17 POGZ KCTD1 RUNX2 RFX7 WNK1 MEF2C UNC80 SMAD4

1.24e-0413852516HP:0001167
HumanPhenoThin vermilion border

BPTF ASXL3 POGZ RUNX2 RFX7 MEF2C MED13 UNC80 SMAD4

1.27e-04433259HP:0000233
HumanPhenoThin upper lip vermilion

BPTF ASXL3 POGZ RFX7 MEF2C MED13 UNC80 SMAD4

1.41e-04339258HP:0000219
HumanPhenoThin lips

BPTF ASXL3 POGZ RFX7 MEF2C MED13 UNC80 SMAD4

1.41e-04339258HP:0000213
HumanPhenoAbnormal calvaria morphology

KMT2C PNPLA6 KMT2B MTHFR BICRA ASXL3 POGZ KCTD1 CTNND1 RUNX2 RFX7 WNK1 MEF2C UNC80 SMAD4

1.71e-0412542515HP:0002683
HumanPhenoOverfolding of the superior helices

SALL1 BICRA

2.29e-045252HP:0004453
HumanPhenoFlared metaphysis

BPTF SALL1 BICRA POGZ KCTD1 RUNX2

2.51e-04191256HP:0003015
HumanPhenoAbnormal 2nd metacarpal morphology

SALL1 RUNX2

3.43e-046252HP:0010010
HumanPhenoAbnormal finger phalanx morphology

BPTF SALL1 PNPLA6 KMT2B BICRA ASXL3 POGZ KCTD1 RUNX2 WNK1 UNC80

3.50e-047382511HP:0005918
HumanPhenoAbnormal shape of the frontal region

PNPLA6 KMT2B MTHFR BICRA POGZ KCTD1 CTNND1 RUNX2 RFX7 MEF2C UNC80

3.63e-047412511HP:0011218
HumanPhenoAbnormal frontal bone morphology

PNPLA6 KMT2B MTHFR BICRA POGZ KCTD1 CTNND1 RUNX2 RFX7 MEF2C UNC80

3.67e-047422511HP:0430000
HumanPhenoAbnormality of the palpebral fissures

BPTF KMT2C SALL1 BICRA ASXL3 POGZ KCTD1 RFX7 MEF2C MED13 UNC80 SMAD4

3.77e-048802512HP:0008050
HumanPhenoDiagnostic behavioral phenotype

KMT2C USF3 KMT2B MTHFR BICRA ASXL3 POGZ RFX7 MEF2C MED13 SMAD4

3.90e-047472511HP:0025783
HumanPhenoAbnormal size of the palpebral fissures

BPTF SALL1 BICRA KCTD1 RFX7 MED13 SMAD4

4.21e-04298257HP:0200007
HumanPhenoAbnormal earlobe morphology

KMT2C KMT2B BICRA KCTD1 SMAD4

4.50e-04137255HP:0000363
HumanPhenoTriangular shaped phalanges of the hand

BPTF SALL1 BICRA POGZ KCTD1 RUNX2

4.64e-04214256HP:0009774
HumanPhenoLong fingers

KMT2C ASXL3 RUNX2 RFX7 WNK1 UNC80 SMAD4

4.95e-04306257HP:0100807
HumanPhenoAbnormality of the chin

BICRA ASXL3 POGZ KCTD1 RUNX2 RFX7 MEF2C SMAD4

5.14e-04409258HP:0000306
HumanPhenoClinodactyly of the 5th finger

BPTF SALL1 PNPLA6 KMT2B KCTD1 RUNX2 MEF2C SMAD4

6.15e-04420258HP:0004209
HumanPhenoClinodactyly of hands

BPTF SALL1 PNPLA6 KMT2B KCTD1 RUNX2 MEF2C SMAD4

6.25e-04421258HP:0001157
HumanPhenoDeviation of the 5th finger

BPTF SALL1 PNPLA6 KMT2B KCTD1 RUNX2 MEF2C SMAD4

6.25e-04421258HP:0009179
HumanPhenoBroad phalanx

BPTF SALL1 BICRA POGZ KCTD1

6.42e-04148255HP:0006009
HumanPhenoBroad phalanges of the hand

BPTF SALL1 BICRA POGZ KCTD1

6.42e-04148255HP:0009768
HumanPhenoAbnormal hand morphology

BPTF SALL1 PNPLA6 KMT2B BICRA ASXL3 ADAMTS17 KCTD1 RUNX2 WNK1 MEF2C UNC80 SMAD4

6.61e-0410822513HP:0005922
HumanPhenoAbnormal eyelid morphology

BPTF KMT2C SALL1 PNPLA6 KMT2B BICRA ASXL3 POGZ KCTD1 CTNND1 RFX7 MEF2C MED13 UNC80 SMAD4

6.79e-0414082515HP:0000492
HumanPhenoMetaphyseal widening

BPTF SALL1 BICRA POGZ KCTD1 RUNX2

7.14e-04232256HP:0003016
HumanPhenoBrachydactyly (hand)

BPTF SALL1 BICRA ADAMTS17 POGZ KCTD1 RUNX2 SMAD4

7.21e-04430258HP:0100667
HumanPhenoBrachydactyly

BPTF USF3 SALL1 PNPLA6 BICRA ADAMTS17 POGZ KCTD1 RUNX2 SMAD4

7.37e-046702510HP:0001156
HumanPhenoShort digit

BPTF USF3 SALL1 PNPLA6 BICRA ADAMTS17 POGZ KCTD1 RUNX2 SMAD4

7.55e-046722510HP:0011927
HumanPhenoBroad finger

BPTF SALL1 BICRA POGZ KCTD1

7.70e-04154255HP:0001500
HumanPhenoAutistic behavior

KMT2C USF3 KMT2B BICRA ASXL3 POGZ RFX7 MEF2C MED13 SMAD4

8.11e-046782510HP:0000729
HumanPhenoCleft soft palate

KMT2C BICRA POGZ KCTD1 RFX7 SMAD4

8.17e-04238256HP:0000185
HumanPhenoBroad long bones

BPTF SALL1 BICRA POGZ KCTD1

8.41e-04157255HP:0005622
HumanPhenoCleft secondary palate

KMT2C BICRA POGZ KCTD1 RFX7 SMAD4

8.54e-04240256HP:0410004
HumanPhenoSlender finger

BPTF BICRA ASXL3 UNC80 SMAD4

8.91e-04159255HP:0001238
HumanPhenoDeviation of the hand or of fingers of the hand

BPTF SALL1 PNPLA6 KMT2B ASXL3 KCTD1 RUNX2 MEF2C SMAD4

9.35e-04564259HP:0009484
HumanPhenoRadial deviation of finger

BPTF SALL1 PNPLA6 KMT2B KCTD1 RUNX2 MEF2C SMAD4

9.48e-04448258HP:0009466
HumanPhenoMucosal telangiectasiae

USF3 KIAA0319L SMAD4

9.84e-0441253HP:0100579
HumanPhenoAbnormal metaphysis morphology

BPTF SALL1 BICRA POGZ KCTD1 RUNX2 SMAD4

1.00e-03344257HP:0000944
HumanPhenoFinger clinodactyly

BPTF SALL1 PNPLA6 KMT2B KCTD1 RUNX2 MEF2C SMAD4

1.01e-03452258HP:0040019
HumanPhenoAbnormal antitragus morphology

PNPLA6 KCTD1

1.02e-0310252HP:0009896
HumanPhenoAbnormality of calvarial morphology

KMT2C PNPLA6 KMT2B MTHFR BICRA ASXL3 POGZ KCTD1 CTNND1 RUNX2 RFX7 MEF2C UNC80

1.06e-0311342513HP:0002648
HumanPhenoClinodactyly

BPTF SALL1 PNPLA6 KMT2B KCTD1 RUNX2 RFX7 MEF2C SMAD4

1.06e-03574259HP:0030084
HumanPhenoRadial deviation of the hand or of fingers of the hand

BPTF SALL1 PNPLA6 KMT2B KCTD1 RUNX2 MEF2C SMAD4

1.07e-03456258HP:0009485
HumanPhenoAbnormal midface morphology

BPTF KMT2C SALL1 KMT2B BICRA ASXL3 POGZ RUNX2 RFX7 SMAD4

1.10e-037042510HP:0000309
HumanPhenoAbnormal pinna morphology

BPTF KMT2C SALL1 PNPLA6 KMT2B MTHFR BICRA ASXL3 POGZ KCTD1 RFX7 MEF2C UNC80 SMAD4

1.10e-0312992514HP:0000377
HumanPhenoBifid uvula

KMT2C POGZ KCTD1 RFX7 SMAD4

1.11e-03167255HP:0000193
HumanPhenoBrachycephaly

KMT2C PNPLA6 POGZ RUNX2 RFX7 UNC80

1.13e-03253256HP:0000248
HumanPhenoShort philtrum

BPTF POGZ RUNX2 MEF2C UNC80 SMAD4

1.13e-03253256HP:0000322
HumanPhenoAbnormal antihelix morphology

SALL1 BICRA KCTD1

1.13e-0343253HP:0009738
HumanPhenoAbnormality of refraction

BPTF KMT2C USF3 PNPLA6 KMT2B BICRA ASXL3 ADAMTS17 POGZ SMAD4

1.16e-037092510HP:0000539
HumanPhenoAbnormality of upper lip vermillion

BPTF ASXL3 POGZ RFX7 MEF2C MED13 UNC80 SMAD4

1.20e-03464258HP:0011339
HumanPhenoPeriorbital fullness

KMT2B ASXL3 MED13

1.29e-0345253HP:0000629
HumanPhenoAbnormal pubic bone morphology

KIAA0319L RUNX2 SMAD4

1.29e-0345253HP:0003172
HumanPhenoPosteriorly rotated ears

PNPLA6 KMT2B BICRA ASXL3 POGZ KCTD1 RFX7 UNC80

1.30e-03470258HP:0000358
HumanPhenoDeeply set eye

BPTF KMT2B BICRA ASXL3 MEF2C SMAD4

1.46e-03266256HP:0000490
HumanPhenoSevere expressive language delay

KMT2C POGZ

1.48e-0312252HP:0006863
HumanPhenoAbnormality of the outer ear

BPTF KMT2C SALL1 PNPLA6 KMT2B MTHFR BICRA ASXL3 POGZ KCTD1 RFX7 MEF2C UNC80 SMAD4

1.50e-0313372514HP:0000356
HumanPhenoFrontal bossing

PNPLA6 KMT2B BICRA POGZ KCTD1 CTNND1 RUNX2 RFX7 MEF2C UNC80

1.59e-037382510HP:0002007
MousePhenoabnormal polar trophectoderm morphology

BPTF PNPLA6 POU2F1 SMAD4

2.41e-0539614MP:0012056
MousePhenoabnormal ectoplacental cone morphology

BPTF PNPLA6 POU2F1 SMAD4

2.41e-0539614MP:0005032
MousePhenosmall ectoplacental cone

BPTF PNPLA6 SMAD4

2.78e-0514613MP:0002584
DomainTF_octamer

POU2F1 POU2F2 POU2F3

5.97e-083743IPR000972
DomainGSCR1_dom

BICRA BICRAL

1.55e-052742IPR015671
DomainGLTSCR1

BICRA BICRAL

1.55e-052742PF15249
DomainPOU

POU2F1 POU2F2 POU2F3

3.22e-0516743SM00352
DomainPOU_2

POU2F1 POU2F2 POU2F3

3.22e-0516743PS00465
DomainPOU_dom

POU2F1 POU2F2 POU2F3

3.22e-0516743IPR000327
DomainPOU_3

POU2F1 POU2F2 POU2F3

3.22e-0516743PS51179
DomainPou

POU2F1 POU2F2 POU2F3

3.22e-0516743PF00157
DomainPOU_1

POU2F1 POU2F2 POU2F3

3.22e-0516743PS00035
DomainZF_PHD_2

BPTF KMT2C KMT2B ASXL3 MLLT10

3.74e-0595745PS50016
DomainPOU

POU2F1 POU2F2 POU2F3

3.90e-0517743IPR013847
DomainZF_PHD_1

BPTF KMT2C KMT2B ASXL3 MLLT10

3.93e-0596745PS01359
DomainEPHD

KMT2C KMT2B MLLT10

8.71e-0522743PS51805
DomainFYrich_C

KMT2C KMT2B

1.54e-045742IPR003889
DomainFYrich_N

KMT2C KMT2B

1.54e-045742IPR003888
DomainFYRC

KMT2C KMT2B

1.54e-045742SM00542
DomainFYRN

KMT2C KMT2B

1.54e-045742SM00541
DomainFYRN

KMT2C KMT2B

1.54e-045742PF05964
DomainFYRC

KMT2C KMT2B

1.54e-045742PF05965
DomainFYRC

KMT2C KMT2B

1.54e-045742PS51543
DomainFYRN

KMT2C KMT2B

1.54e-045742PS51542
Domain-

POU2F1 POU2F2 POU2F3

1.63e-04277431.10.260.40
DomainLambda_DNA-bd_dom

POU2F1 POU2F2 POU2F3

2.03e-0429743IPR010982
DomainPHD

BPTF KMT2C KMT2B MLLT10

2.23e-0475744PF00628
DomainZnf_PHD-finger

BPTF KMT2C KMT2B MLLT10

2.72e-0479744IPR019787
DomainZnf_FYVE_PHD

BPTF KMT2C KMT2B MLLT10 BSN

2.94e-04147745IPR011011
DomainPHD

BPTF KMT2C KMT2B MLLT10

4.30e-0489744SM00249
DomainZnf_PHD

BPTF KMT2C KMT2B MLLT10

4.68e-0491744IPR001965
DomainPost-SET_dom

KMT2C KMT2B

1.79e-0316742IPR003616
DomainPostSET

KMT2C KMT2B

1.79e-0316742SM00508
DomainPOST_SET

KMT2C KMT2B

1.79e-0316742PS50868
Domainzf-CCHC

ERVK-6 ERVK-5

3.71e-0323742PF00098
Domain-

SCAF8 EPN2

4.73e-03267421.25.40.90
DomainAT_hook

KMT2C KMT2B

5.10e-0327742SM00384
DomainAT_hook_DNA-bd_motif

KMT2C KMT2B

5.10e-0327742IPR017956
DomainENTH_VHS

SCAF8 EPN2

5.87e-0329742IPR008942
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

SP1 KMT2C PPARGC1B KMT2B NFYC HIPK2 POU2F1 POU2F2 MAML2 KCTD1 RUNX2 ZNF282 MEF2C MED13 TFDP2 MOV10 SMAD4

5.21e-0713874517M734
PathwayREACTOME_TGFBR3_EXPRESSION

SP1 MOV10 SMAD4

9.42e-0528453M48253
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS

TSC22D1 SALL1 SMAD4

1.28e-0431453M27393
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

SP1 RUNX2 MEF2C SMAD4

1.32e-0482454M2
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

SP1 CTNND1 MOV10

1.41e-0432453M48012
PathwayBIOCARTA_TERC_PATHWAY

SP1 NFYC

1.48e-046452MM1564
PathwayBIOCARTA_TERC_PATHWAY

SP1 NFYC

1.48e-046452M22047
PathwayREACTOME_ONCOGENE_INDUCED_SENESCENCE

SP1 TFDP2 MOV10

1.85e-0435453M27190
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

SP1 TFDP2 SMAD4

2.02e-0436453M633
PathwayREACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT

RUNX2 SMAD4

2.07e-047452MM15533
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

SP1 KMT2B HIPK2 POU2F1 POU2F2 MAML2 KCTD1 NUP58 RUNX2 ZNF282 SMAD4

2.83e-0410224511MM15436
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

TFEB SP1 SALL1 POU2F1 MEF2C SMAD4

3.64e-04301456MM15983
PathwayWP_WNT_SIGNALING_PATHWAY

SALL1 HIPK2 RUNX2 SMAD4

4.09e-04110454MM15977
PathwayREACTOME_SIGNALING_BY_TGFBR3

SP1 MOV10 SMAD4

5.05e-0449453M48250
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

SP1 PPARGC1B NFYC MED13

5.33e-04118454M27316
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

SP1 TFDP2 SMAD4

5.69e-0451453M665
PathwayREACTOME_REGULATION_OF_CDH11_EXPRESSION_AND_FUNCTION

SP1 CTNND1

6.44e-0412452MM17071
PathwayWP_BONE_MORPHOGENIC_PROTEIN_SIGNALING_AND_REGULATION

RUNX2 SMAD4

6.44e-0412452M39519
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS

PPARGC1B MEF2C CRTC2

7.10e-0455453M27145
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

SP1 CTNND1 MOV10

8.30e-0458453M11980
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

KMT2C KMT2B HIPK2 RUNX2 MOV10

9.09e-04237455M27786
PathwayREACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION

HIPK2 RUNX2

1.02e-0315452M603
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

HIPK2 MEF2C MOV10

1.06e-0363453M27862
PathwayPID_MYC_REPRESS_PATHWAY

SP1 NFYC SMAD4

1.06e-0363453M254
PathwayREACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS

SP1 SMAD4

1.16e-0316452M46428
PathwayWP_STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP_SIGNALING

SP1 PPARGC1B SEC31B

1.49e-0371453M39395
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES

SP1 POU2F1 POU2F2

1.62e-0373453MM15349
PathwayWP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS

SP1 PPARGC1B POU2F2 MEF2C

1.62e-03159454M39373
PathwayWP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION

RUNX2 SMAD4

1.65e-0319452M39370
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

SP1 PPARGC1B

1.65e-0319452M39544
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

SP1 PPARGC1B

1.65e-0319452MM15973
PathwayREACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_DREAM_COMPLEX

TOP2A TFDP2

1.65e-0319452M26939
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

SP1 TFDP2 MOV10 SMAD4

1.70e-03161454M27871
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES

SP1 POU2F1 POU2F2

2.18e-0381453M27647
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

MAML2 MEF2C SMAD4

2.26e-0382453MM15922
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TFEB BPTF SP1 TSC22D1 CPHXL SALL1 NFYC POU2F1 POU2F2 POGZ MLLT10 RUNX2 ZNF236 POU2F3 ZNF282 TFDP2 SMAD4

1.26e-11808861720412781
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-5 ERVK-19 ERVK-10

3.48e-1148647983737
Pubmed

Interaction network of human early embryonic transcription factors.

BPTF KMT2C FOXP4 SALL1 KMT2B BICRA ASXL3 POU2F1 POGZ NUP58 RFX7 TOP2A

7.25e-11351861238297188
Pubmed

A census of human transcription factors: function, expression and evolution.

TFEB SP1 TSC22D1 FOXP4 USF3 SALL1 NFYC POU2F1 POU2F2 RUNX2 ZNF236 RFX7 POU2F3 ZNF282 MEF2C TFDP2 SMAD4

7.73e-11908861719274049
Pubmed

Human transcription factor protein interaction networks.

BPTF SP1 KMT2C FOXP4 SALL1 KMT2B SCAF8 BICRA PRRC2C NFYC HIPK2 POU2F1 POGZ MLLT10 RFX7 MEF2C YTHDF2 TFDP2 MOV10

1.61e-091429861935140242
Pubmed

A human MAP kinase interactome.

SP1 KMT2C TSC22D1 USF3 BICRA NFYC HIPK2 BICRAL POGZ NUP58 WNK1 MEF2C

2.91e-09486861220936779
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-5 ERVK-19 ERVK-21 ERVK-9 ERVK-10 ERVK-24

3.79e-099486721542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-19 ERVK-21 ERVK-9

1.70e-081286414557543
Pubmed

Cloning and sequencing of POU-boxes expressed in mouse testis.

POU2F1 POU2F2 POU2F3

5.83e-0848631970171
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-10 ERVK-24

5.83e-08486310469592
Pubmed

Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation.

POU2F1 POU2F2 POU2F3

5.83e-0848639242494
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.04e-071886418664271
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

SP1 USF3 SALL1 BICRA MAML2 TEX14 MLLT10 BSN WNK1 CRTC2

1.15e-07430861035044719
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-21

1.45e-07586312629516
Pubmed

Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.

SP1 POU2F1 POU2F2

1.45e-07586316061936
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

BPTF FOXP4 SALL1 PRRC2C NFYC POU2F1 POU2F2 POGZ CTNND1 MEF2C TOP2A MOV10 SMAD4

1.87e-07857861325609649
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19 ERVK-9

2.90e-07686315063128
Pubmed

Rebalancing gene haploinsufficiency in vivo by targeting chromatin.

KMT2C PPARGC1B KMT2B MEF2C

6.82e-072886427256596
Pubmed

OCT-4: a novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells.

POU2F1 POU2F2 POU2F3

8.10e-07886327065334
Pubmed

Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo.

SP1 POU2F1 MEF2C

1.21e-0698639738004
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19 ERVK-21

1.73e-061086312970426
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

BPTF KMT2C SALL1 KMT2B POGZ MOV10

1.76e-0614686623892456
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

RHOG BPTF KMT2C KMT2B MYCBP2 BICRA PRRC2C POU2F1 BICRAL POGZ RUNX2 RBM39 TOP2A

3.12e-061103861334189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TFEB KMT2C PNPLA6 KMT2B MYCBP2 MTHFR BICRA KIAA0319L AP1G2 MLLT10 ZNF236 WNK1 MED13

3.18e-061105861335748872
Pubmed

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

TFEB SP1 SALL1 NFYC TOP2A

3.23e-069186520362542
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

BPTF SP1 PNPLA6 KMT2B MYCBP2 SCAF8 POU2F1 POGZ RFX7 TOP2A MED13

3.32e-06774861115302935
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BPTF EP400P1 KMT2C TSC22D1 PPARGC1B FOXP4 USF3 PNPLA6 MYCBP2 SCAF8 BICRA HIPK2 CTNND1 ZNF236 RBM39

3.46e-061489861528611215
Pubmed

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.

TFEB MYCBP2 WNK1 CRTC2

3.63e-064286423444366
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

BPTF KMT2C FOXP4 SALL1 POGZ MED13

3.83e-0616786620362541
Pubmed

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

SP1 POU2F1 POGZ

5.21e-061486310976766
Pubmed

The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression.

SP1 POU2F1

6.04e-0628628668525
Pubmed

Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2.

POU2F1 POU2F2

6.04e-06286212663137
Pubmed

Functional interaction of Oct transcription factors with the family of repeats in Epstein-Barr virus oriP.

POU2F1 POU2F2

6.04e-06286215831936
Pubmed

Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping.

POU2F1 POU2F2

6.04e-06286211583619
Pubmed

Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.

POU2F1 POU2F2

6.04e-06286231771949
Pubmed

Identification of novel single-stranded DNA binding proteins recognizing octamer motif.

POU2F1 POU2F2

6.04e-0628628185580
Pubmed

Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1.

SP1 MEF2C

6.04e-0628629748305
Pubmed

O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1.

SP1 POU2F1

6.04e-06286219070619
Pubmed

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase the binding activity and nuclear level of Oct-1 in mononuclear cells.

POU2F1 POU2F2

6.04e-06286212144930
Pubmed

YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation.

HIPK2 YTHDF2

6.04e-06286238147784
Pubmed

Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein.

POU2F1 RUNX2

6.04e-06286215798204
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

6.04e-0628629060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

6.04e-0628629460924
Pubmed

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.

POU2F1 POU2F2

6.04e-0628628156594
Pubmed

Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats).

SP1 RUNX2

6.04e-06286219017640
Pubmed

SALL1 regulates commitment of odontoblast lineages by interacting with RUNX2 to remodel open chromatin regions.

SALL1 RUNX2

6.04e-06286233159702
Pubmed

Sp1 is necessary for gene activation of Adamts17 by estrogen.

SP1 ADAMTS17

6.04e-06286224906090
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

BPTF KMT2C KMT2B POGZ ZNF282

1.20e-0511986523508102
Pubmed

Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix.

SP1 POU2F1

1.81e-0538629525610
Pubmed

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

POU2F1 POU2F2

1.81e-0538622905684
Pubmed

Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.

SP1 RUNX2

1.81e-05386219306294
Pubmed

MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1.

RUNX2 MEF2C

1.81e-05386233303006
Pubmed

Mef2 promotes spine elimination in absence of δ-catenin.

CTNND1 MEF2C

1.81e-05386223328440
Pubmed

Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1.

POU2F1 POU2F2

1.81e-0538628622679
Pubmed

Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding.

POU2F1 POU2F2

1.81e-05386210490647
Pubmed

Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.

POU2F1 POU2F2

1.81e-0538629584182
Pubmed

Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells.

POU2F1 POU2F2

1.81e-05386217442950
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

1.81e-0538629971820
Pubmed

SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.

SALL1 SMAD4

1.81e-05386237322178
Pubmed

High mobility group I/Y protein functions as a specific cofactor for Oct-2A: mapping of interaction domains.

POU2F1 POU2F2

1.81e-0538629823775
Pubmed

Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.

POU2F1 POU2F2

1.81e-05386214729950
Pubmed

OBF1 and Oct factors control the germinal center transcriptional program.

POU2F1 POU2F2

1.81e-05386233512466
Pubmed

YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation.

RUNX2 YTHDF2

1.81e-05386236216883
Pubmed

Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the Specificity of DNA Recognition by the POU-Domain Factors OCT1 and OCT2 in a Monomeric Configuration.

POU2F1 POU2F2

1.81e-05386238254723
Pubmed

Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.

SP1 NFYC

1.81e-05386222412893
Pubmed

Identification of a critical Sp1 site within the endoglin promoter and its involvement in the transforming growth factor-beta stimulation.

SP1 SMAD4

1.81e-05386211432852
Pubmed

Histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide attenuates plasminogen activator inhibitor-1 expression in human pleural mesothelial cells.

SP1 SMAD4

1.81e-05386222033265
Pubmed

CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.

POU2F1 POU2F3

1.81e-0538628376772
Pubmed

Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter.

POU2F1 POU2F2

1.81e-05386219710692
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

1.81e-05386210516026
Pubmed

The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP.

POU2F1 POU2F2

1.81e-0538628202368
Pubmed

[Study of the 482G/A variation in PGC-1alpha gene domain MEF2C as possible mechanism of type 2 diabetes].

PPARGC1B MEF2C

1.81e-05386219065516
Pubmed

Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression.

RUNX2 MEF2C

1.81e-05386224692107
Pubmed

Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1.

SP1 SMAD4

1.81e-05386214570593
Pubmed

Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2.

POU2F1 POU2F2

1.81e-05386224367622
Pubmed

Endothelial Aquaporin-1 (AQP1) Expression Is Regulated by Transcription Factor Mef2c.

SP1 MEF2C

1.81e-05386226923194
Pubmed

Tagging genes with cassette-exchange sites.

BPTF KMT2C SCAF8 PRRC2C RFX7 RBM39 SMAD4

2.02e-0533586715741177
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

RHOG SP1 KMT2C SALL1 BICRA POU2F1 MAML2 KCTD1 ZNF236 WNK1 RBM39 YTHDF2 MED13

2.24e-051327861332694731
Pubmed

The finished DNA sequence of human chromosome 12.

FAM186A ERVK-21 WNK1 DDX11L8

2.66e-056986416541075
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2C KMT2B

3.61e-05486219221051
Pubmed

A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding.

MLLT10 EPN2

3.61e-05486212750376
Pubmed

High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.

POU2F1 POU2F2

3.61e-0548627720710
Pubmed

Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors.

SP1 SMAD4

3.61e-05486219558215
Pubmed

Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.

RUNX2 SMAD4

3.61e-05486218986983
Pubmed

Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.

POU2F1 POU2F2

3.61e-05486226016715
Pubmed

Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells.

SP1 SMAD4

3.61e-05486211114293
Pubmed

Smad-Sp1 complexes mediate TGFbeta-induced early transcription of oncogenic Smad7 in pancreatic cancer cells.

SP1 SMAD4

3.61e-05486216714330
Pubmed

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

SP1 SMAD4

3.61e-05486210878024
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2C KMT2B

3.61e-05486223129768
Pubmed

Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation.

TSC22D1 SMAD4

3.61e-05486215881652
Pubmed

Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.

POU2F1 POU2F3

3.61e-0548628131747
Pubmed

The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors.

POU2F1 POU2F2

3.61e-0548629368058
Pubmed

The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.

TFEB MYCBP2

3.61e-05486227278822
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

BPTF KMT2C KMT2B PRRC2C POGZ TOP2A

3.86e-0525186631076518
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

TSC22D1 R3HCC1L MYCBP2 MTHFR KANK4 HIPK2 RIPOR3 KCTD1 ERVK-10 CTNND1 RUNX2 MED13

4.41e-051215861215146197
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KMT2C POGZ MAML2 NUP58 BSN MINDY1 MED13 LRRC47

5.10e-0552986814621295
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

KMT2C MYCBP2 POU2F1 LINGO2 MAML2 ZNF236

5.22e-0526586619240061
Pubmed

The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3.

SP1 POU2F3

6.01e-05586223341029
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-5

6.01e-05586211401426
Pubmed

S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.

POU2F1 POU2F2

6.01e-05586212887926
InteractionFEV interactions

KMT2C FOXP4 SALL1 KMT2B BICRA POU2F1 POGZ MLLT10

1.44e-06203808int:FEV
InteractionNFIX interactions

BPTF KMT2C SALL1 KMT2B BICRA POU2F1 POGZ SMAD4

3.31e-06227808int:NFIX
InteractionKLF8 interactions

BPTF SP1 FOXP4 KMT2B BICRA PRRC2C POU2F1 POGZ YTHDF2

6.19e-06329809int:KLF8
InteractionNFYC interactions

SP1 USF3 BICRA NFYC BICRAL POGZ RFX7

6.63e-06177807int:NFYC
InteractionCRX interactions

SP1 KMT2C FOXP4 SALL1 BICRA NFYC POU2F1 POGZ

7.56e-06254808int:CRX
InteractionHNF4A interactions

BPTF SP1 KMT2C PPARGC1B KMT2B BICRA POGZ SMAD4

1.35e-05275808int:HNF4A
InteractionPAX6 interactions

BPTF KMT2C SALL1 BICRA NFYC HIPK2 POU2F1 POGZ SMAD4

1.45e-05366809int:PAX6
InteractionTLX3 interactions

SP1 KMT2C FOXP4 SALL1 POU2F1 POGZ TFDP2 SMAD4

2.02e-05291808int:TLX3
InteractionPGR interactions

BPTF SP1 POU2F1 POU2F2 RBM39

2.10e-0584805int:PGR
InteractionGSC interactions

KMT2C FOXP4 SALL1 ASXL3 POU2F1

2.49e-0587805int:GSC
InteractionFHL2 interactions

SP1 PRRC2C NFYC HIPK2 POGZ RUNX2 MAP10 WNK1 SMAD4

2.70e-05396809int:FHL2
InteractionSP4 interactions

SP1 NFYC POU2F1 POGZ

3.31e-0546804int:SP4
InteractionNFYA interactions

SP1 NFYC POU2F1 POGZ MOV10

6.15e-05105805int:NFYA
InteractionNR2F1 interactions

SP1 FOXP4 POU2F1 POU2F2

8.30e-0558804int:NR2F1
InteractionPOU5F1 interactions

TFEB BPTF SP1 FOXP4 SALL1 SCAF8 NFYC MLLT10 TOP2A LRRC47

1.03e-045848010int:POU5F1
InteractionNANOG interactions

BPTF SP1 KMT2C SALL1 KMT2B POGZ TOP2A MOV10 SMAD4

1.20e-04481809int:NANOG
InteractionSMAD2 interactions

BPTF SP1 KMT2C NFYC HIPK2 RUNX2 MEF2C SMAD4

1.44e-04385808int:SMAD2
InteractionELF1 interactions

BPTF SP1 KMT2B NFYC POGZ

1.46e-04126805int:ELF1
InteractionCTNNB1 interactions

RHOG SP1 TSC22D1 SALL1 NFYC MLLT10 CTNND1 RUNX2 RBM39 YTHDF2 TOP2A MOV10 SMAD4

1.60e-0410098013int:CTNNB1
InteractionHCFC1 interactions

SP1 KMT2C PPARGC1B KMT2B PRRC2C ASXL3 POU2F1

1.64e-04293807int:HCFC1
GeneFamilyPOU class homeoboxes and pseudogenes

POU2F1 POU2F2 POU2F3

1.86e-0523413523
GeneFamilyPHD finger proteins

BPTF KMT2C KMT2B MLLT10

5.05e-059041488
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2B

2.69e-0334412487
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

BPTF SP1 KMT2C KMT2B PRRC2C RFX7 WNK1 MED13

6.59e-08180788M8239
CoexpressionQI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED_WITH_EXPANSION_OF_VZV_SPECIFIC_T_CELLS_TO_PEAK_AT_1DY_POSITIVE

RHOG PRRC2C LILRB2 KIAA0319L RUNX2 SMAD4 LRRC47

9.30e-06248787M40874
CoexpressionGSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN

TFEB RHOG LILRB2 POU2F1 POU2F2 CTNND1

2.74e-05197786M5853
CoexpressionGSE3920_UNTREATED_VS_IFNB_TREATED_ENDOTHELIAL_CELL_UP

FOXP4 MFSD14B AP1G2 BICRAL RUNX2 SMAD4

2.98e-05200786M6686
CoexpressionGSE43956_WT_VS_SGK1_KO_TH17_DIFFERENTIATED_CD4_TCELL_DN

TSC22D1 MFSD14B GPR37L1 RBM39 MOV10 SMAD4

2.98e-05200786M9628
CoexpressionNIKOLSKY_OVERCONNECTED_IN_BREAST_CANCER

NFYC POU2F1 MEF2C

3.24e-0521783M10991
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

BPTF MYCBP2 SCAF8 PRRC2C NFYC RBM39 TOP2A MED13

7.42e-05466788M13522
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

BPTF SALL1 MFSD14B HIPK2 POGZ WNK1 TOP2A

6.60e-08199797358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellnormal_Lymph_Node-B_lymphocytes-Undetermined|normal_Lymph_Node / Location, Cell class and cell subclass

TFEB CYP2A6 PRRC2C POU2F2 MEF2C

1.03e-0516279591ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MFSD14B SCAF8 BICRA GPR37L1 CRTC2

1.31e-051707950f215911b5880eeffeb43230f7eeaf55b612eaf2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSC22D1 ADAMTS17 MAML2 KCTD1 WNK1

2.12e-05188795bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSC22D1 ADAMTS17 MAML2 KCTD1 WNK1

2.12e-05188795eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

BPTF PRRC2C WNK1 RBM39 MED13

2.40e-05193795e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellmild_COVID-19_(asymptomatic)|World / disease group, cell group and cell class (v2)

TFEB TSC22D1 POU2F2 CTNND1 SMAD4

2.59e-051967958cb3dcb3e5732f4bb060c87ca339b8997a1a8cd4
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARPP21 SALL1 ASXL3 LINGO2 UNC80

2.72e-051987958f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellPBMC_fresh-frozen|World / Compartment, severity and other cell annotations on 10x 3' data (130k)

BPTF MYCBP2 PRRC2C POU2F2 RBM39

2.72e-05198795dcc223a0396b8b673e4ed8c6733ec6cd74e9a03a
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARPP21 SALL1 ASXL3 LINGO2 UNC80

2.72e-05198795e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BPTF KMT2C MYCBP2 PRRC2C RBM39

2.85e-0520079512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellCOVID-19|World / Disease, condition lineage and cell class

BPTF KMT2C MYCBP2 PRRC2C RBM39

2.85e-052007957dec470c379cd89f05a0f37c8628b21f136e52f0
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

BPTF KMT2C PRRC2C HIPK2 MEF2C

1.20e-0649425GAVISH_3CA_MALIGNANT_METAPROGRAM_41_UNASSIGNED
Diseaseimmune system disease (implicated_via_orthology)

POU2F1 POU2F2 POU2F3

1.64e-083763DOID:2914 (implicated_via_orthology)
DiseaseLiver Diseases, Parasitic

CYP2A6 KMT2C SMAD4

1.36e-069763C0023897
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

KMT2B RFX7 MED13

1.09e-0517763DOID:0060307 (is_implicated_in)
DiseaseNeurodevelopmental Disorders

KMT2C ASXL3 POGZ MEF2C

9.97e-0593764C1535926
Diseaseneuroimaging measurement, brain volume measurement

BPTF POU2F2 MLLT10 RUNX2 TFDP2

8.70e-04286765EFO_0004346, EFO_0006930
Diseasesquamous cell carcinoma (is_implicated_in)

KMT2C MTHFR

9.75e-0418762DOID:1749 (is_implicated_in)
DiseaseIntellectual Disability

BPTF KMT2C CNKSR1 POGZ MEF2C MED13

1.04e-03447766C3714756
Diseasesudden cardiac arrest

AP1G2 MAML2 KCTD1

1.30e-0383763EFO_0004278
DiseaseParkinson disease

SP1 MYCBP2 ASXL3 MED13 SMAD4

1.45e-03321765MONDO_0005180
Diseaseleft ventricular structural measurement

TFEB C6orf15 RUNX2

1.54e-0388763EFO_0008205
DiseaseIntrahepatic Cholangiocarcinoma

KMT2C SMAD4

1.74e-0324762C0345905
DiseaseExtrahepatic Cholangiocarcinoma

KMT2C SMAD4

1.74e-0324762C3805278
DiseaseCholangiocarcinoma

KMT2C SMAD4

2.04e-0326762C0206698
Diseasecognitive function measurement, self reported educational attainment

ARPP21 MYCBP2 C6orf15 BSN MEF2C

2.25e-03355765EFO_0004784, EFO_0008354
Diseasesodium measurement

CYP2A6 ARPP21 MLLT10

2.41e-03103763EFO_0009282

Protein segments in the cluster

PeptideGeneStartEntry
PGPQQQAFQLLQGLE

CYP2A6

231

P11509
NETQTSGNQILPNGP

CDKL4

331

Q5MAI5
SGNQILPNGPILQNS

CDKL4

336

Q5MAI5
LQLQLQAPSGNTVPA

AP1G2

721

O75843
QGQGQTTGQLQLIPQ

BPTF

2296

Q12830
GTLHQQPLPQKGANQ

CCDC157

131

Q569K6
QQGFQGLIGVQQPPQ

ARPP21

686

Q9UBL0
GLIGVQQPPQSQNVI

ARPP21

691

Q9UBL0
NNPLVTQLLQGNLPL

ASXL3

1746

Q9C0F0
VLIQPLNNSQGPFSG

ADAMTS17

161

Q8TE56
QQQGAPNAGVITNAP

R3HCC1L

121

Q7Z5L2
GTGLQIPPAAQQALQ

RBM39

366

Q14498
LSQKILGNLQQLQGP

PNPLA6

746

Q8IY17
RQGPQQQGLPQGDTQ

CT55

21

Q8WUE5
RQGILTINSQPNING

MTHFR

476

P42898
TQNSEGQNLGPQAIP

KMT2C

3136

Q8NEZ4
GAQPLQIQPGLLAQQ

HIPK2

691

Q9H2X6
LVNPPHIQNIGATNQ

MAP10

366

Q9P2G4
QETNGQPQGLTGPQA

MAGEB6

16

Q8N7X4
NAGPNQVITLPQNSI

KIAA0319L

506

Q8IZA0
VNQPQPLTLNQLRGS

EPN2

556

O95208
PGLPQLQSLNLSGNR

LRRC47

126

Q8N1G4
QQQGLGLQPPQQALT

BSN

3781

Q9UPA5
GLQPPQQALTQARLQ

BSN

3786

Q9UPA5
ASPLNNQGIPTPAQL

KCTD1

11

Q719H9
QLPQQTQGALLTSQP

POU2F2

146

P09086
ALSLQQQQPRGPLGL

MINDY1

396

Q8N5J2
QLPGRQPQAGLSQAN

LILRB2

266

Q8N423
ANLPPQISSIIQGQL

EP400P1

251

Q6ZTU2
ILQRQPTLQFGGQQP

LINGO2

366

Q7L985
NSPGLLVSPGNLNKN

MEF2C

221

Q06413
GLVSLQPNQASGPLQ

FOXP4

201

Q8IVH2
QPNQASGPLQTLPQA

FOXP4

206

Q8IVH2
ALSNGPQTQAQLLQP

KMT2B

726

Q9UMN6
LLSQTQPGQQGLQPN

POU2F3

111

Q9UKI9
QQQSGLLLPQTGPGL

POU2F3

131

Q9UKI9
GQIIIAQPQQGQTTP

NFYC

176

Q13952
FIISQTPQGQQGLLQ

POU2F1

206

P14859
TPQGQQGLLQAQNLL

POU2F1

211

P14859
TQILPNLNQSGTGLN

MAML2

1056

Q8IZL2
VSQNLGTNLPQLGQP

C6orf15

36

Q6UXA7
GQQPPLSQVFQGISQ

ERVK-10

636

P87889
GQQPPLSQVFQGISQ

ERVK-19

636

Q9YNA8
GQQPPLSQVFQGISQ

ERVK-21

636

P62683
GQQPPLSQVFQGISQ

ERVK-24

636

P63145
QKIPPLQGVSQLQQS

ERVK-5

641

Q9HDB9
GQQPPLSQVFQGISQ

ERVK-6

636

Q7LDI9
GQQPPLSQVFQGISQ

ERVK-9

636

P63126
GQQPPLSQVFQGISQ

HERVK_113

636

P62684
NGQLLQTQPSQLISG

BICRAL

421

Q6AI39
SQLQSQLPQNNGKPL

CPHXL2

326

A0A1W2PPK0
QLPQNNGKPLCSQLQ

CPHXL2

331

A0A1W2PPK0
NLQASLSSPQPQLQG

CRTC2

351

Q53ET0
LTGAPGQRLQIQNPL

GPR37L1

106

O60883
VLGGNIKQNPNTQSL

DDX11L8

456

A8MPP1
SQPPEQLGLQTNLGN

DSCR8

56

Q96T75
LGTQEQNQSPPLGNA

KANK4

101

Q5T7N3
QQAQALGIPLTPQQT

FAM186A

1126

A6NE01
TQQAQKLGIPLTPQQ

FAM186A

1161

A6NE01
AQQLGIPLTPQQAQA

FAM186A

1236

A6NE01
ELGIPLNPQQAQTLG

FAM186A

1286

A6NE01
QALGIPLTPQQAQTQ

FAM186A

1321

A6NE01
TQQAQELGIPLTPQQ

FAM186A

1401

A6NE01
QAQALGIPLTPQQAQ

FAM186A

1571

A6NE01
QGIPLTPQQAQALGI

FAM186A

1611

A6NE01
QLPQQLSALPANVGG

BICRA

481

Q9NZM4
GGQLIANPILTNQNL

BICRA

506

Q9NZM4
ANPILTNQNLAGPLS

BICRA

511

Q9NZM4
IAAQPPNILNNSGIL

SCAF8

841

Q9UPN6
NLGPNQNSAVIPANS

SALL1

1066

Q9NSC2
AIPNLVKNLPGGQQN

CTNND1

751

O60716
LGPKLNSNNVPLQGA

MFSD14B

411

Q5SR56
SQLPQNNGKPLCSQL

CPHXL

356

A0A1W2PPM1
TQQQQPATGPQPSLG

NUP58

471

Q9BVL2
TSNGSTLLNPNLPNQ

RUNX2

476

Q13950
QQQQLGGPPTPAINT

TFEB

41

P19484
GLVQGNPNGSPNRLL

TEX14

181

Q8IWB6
QQGQNLLQGLSKLSP

MOV10

956

Q9HCE1
EQGQAPITPQQGQAL

RHOG

131

P84095
GNPLVQQGGQPLILT

POGZ

96

Q7Z3K3
QQGGQPLILTQNPAP

POGZ

101

Q7Z3K3
GLLQIASGPQPGQQQ

SMAD4

236

Q13485
AQQQGFQPGLSQPTS

PRRC2C

2411

Q9Y520
GQDQQLLRGPQIPAL

PPARGC1B

531

Q86YN6
PSQPGLSQQDLNQLV

SATL1

486

Q86VE3
LNQLVLSQPGLSQPG

SATL1

496

Q86VE3
NVLQGQQPEGLQSEP

MYCBP2

231

O75592
LGQQPSISSLAQPQL

TSC22D1

591

Q15714
SQPQLLGGQRVQVPN

SEC31B

886

Q9NQW1
GQAPSLGQQQQILPK

MED13

441

Q9UHV7
AAPNLQNQQVLTGLP

SP1

151

P08047
QNQQVLTGLPGVMPN

SP1

156

P08047
QNLQLQAVPNSGPII

SP1

436

P08047
QNQGPPALNSTIQLP

TFDP2

261

Q14188
GQQPPLSQVFQGISQ

ERVK-9

636

P63128
VNLTGAGSGLQPQPQ

SUPT20HL2

711

P0C7V6
LLGSAQVPQQGVQLP

SUPT20HL2

731

P0C7V6
PTQIPINNLLAGTQA

MLLT10

1016

P55197
QGGVSLLGQPQPLTQ

CNKSR1

586

Q969H4
EPGQQNLLVQQPLGR

UNC80

3046

Q8N2C7
LQQPTQQALLLGGPR

RIPOR3

361

Q96MK2
LQLAGNTIQPLSQTP

USF3

436

Q68DE3
SNGVTNLPNGNPSIL

RFX7

241

Q2KHR2
VGSNNLNLLQPIGQF

TOP2A

776

P11388
PQPGQQLSITVGINQ

ZNF236

376

Q9UL36
GNIPESGQNQLLQPL

WNK1

2171

Q9H4A3
QPLGQFQPVGTASLQ

WNK1

2346

Q9H4A3
TRPQPQQLGIQGLGL

ZNF282

6

Q9UDV7
ALVQNIGQPTQGSPQ

YTHDF2

291

Q9Y5A9
QPLLNSGQDLNQGPK

VWA5B1

711

Q5TIE3