Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	COL6A3 BIN1 COL28A1 OPRPN SERPINA11 C4A C4B SERPINA9 SERPINA5	1.59e-05	180	161	9	GO:0004866
GeneOntologyMolecularFunction	peptidase inhibitor activity	COL6A3 BIN1 COL28A1 OPRPN SERPINA11 C4A C4B SERPINA9 SERPINA5	2.15e-05	187	161	9	GO:0030414
GeneOntologyMolecularFunction	endopeptidase regulator activity	COL6A3 BIN1 COL28A1 OPRPN SERPINA11 C4A C4B SERPINA9 SERPINA5	3.79e-05	201	161	9	GO:0061135
GeneOntologyMolecularFunction	peptidase regulator activity	COL6A3 BIN1 COL28A1 OPRPN SERPINA11 C4A C4B SERPINA9 SERPINA5	2.46e-04	257	161	9	GO:0061134
GeneOntologyMolecularFunction	nuclear vitamin D receptor binding	NCOA6 TOB2 MED1	3.84e-04	18	161	3	GO:0042809
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B ATP13A4 SLC5A10 TRPA1 SLC38A5 RYR2 CACNA2D4 SLC8B1 KCNH1 KCNN3 SLC4A5 SLC4A11	4.02e-04	465	161	12	GO:0046873
GeneOntologyMolecularFunction	phosphatidylethanolamine binding	GABARAP GABARAPL1 GABARAPL3	4.53e-04	19	161	3	GO:0008429
GeneOntologyMolecularFunction	GABA receptor binding	GABARAP GABARAPL1 GABARAPL3	5.30e-04	20	161	3	GO:0050811
GeneOntologyBiologicalProcess	metal ion transport	CACNA1B ATP13A4 BIN1 EPM2A SLC5A10 TRPA1 ANK3 SLC38A5 DYSF SLC22A17 RYR2 CBLIF CACNA2D4 SLC8B1 PPP3CA KCNH1 KCNN3 MLLT6 SLC4A5 NOS3 WNK4 WNK2 SLC4A11	3.63e-06	1000	162	23	GO:0030001
GeneOntologyBiologicalProcess	monoatomic cation transport	CACNA1B ATP13A4 BIN1 EPM2A SLC5A10 TRPA1 ANK3 SLC38A5 DYSF SLC22A17 RYR2 CBLIF CACNA2D4 SLC8B1 PPP3CA KCNH1 KCNN3 MLLT6 SLC4A5 NOS3 WNK4 UNC80 WNK2 SLC4A11	1.25e-05	1157	162	24	GO:0006812
GeneOntologyBiologicalProcess	cellular response to nutrient levels	SREBF2 SRF GABARAP AMBRA1 MED1 WDR59 GABARAPL1 TNRC6A GABARAPL3 USF1	4.39e-05	262	162	10	GO:0031669
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1B ATP13A4 BIN1 SLC5A10 TRPA1 ANK3 SLC38A5 DYSF RYR2 CBLIF CACNA2D4 SLC8B1 PPP3CA KCNH1 KCNN3 SLC4A5 WNK4 UNC80 WNK2 SLC4A11	5.14e-05	942	162	20	GO:0098655
GeneOntologyBiologicalProcess	sodium ion transport	SLC5A10 ANK3 SLC38A5 SLC8B1 MLLT6 SLC4A5 NOS3 WNK4 WNK2 SLC4A11	6.58e-05	275	162	10	GO:0006814
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1B ATP13A4 BIN1 EPM2A SLC5A10 TRPA1 ANK3 SLC38A5 DYSF SLC22A17 RYR2 CBLIF CACNA2D4 SLC8B1 PPP3CA KCNH1 KCNN3 MLLT6 SLC26A11 SLC4A5 NOS3 WNK4 UNC80 WNK2 SLC4A11	7.11e-05	1374	162	25	GO:0006811
GeneOntologyBiologicalProcess	cellular response to nitrogen levels	GABARAP GABARAPL1 GABARAPL3	9.93e-05	12	162	3	GO:0043562
GeneOntologyBiologicalProcess	cellular response to nitrogen starvation	GABARAP GABARAPL1 GABARAPL3	9.93e-05	12	162	3	GO:0006995
GeneOntologyBiologicalProcess	positive regulation of miRNA transcription	SREBF2 SRF EGR1 KLF5 GNL3	1.17e-04	61	162	5	GO:1902895
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CACNA1B ATP13A4 BIN1 SLC5A10 TRPA1 ANK3 SLC38A5 DYSF RYR2 CBLIF CACNA2D4 SLC8B1 PPP3CA KCNH1 KCNN3 SLC4A5 WNK4 WNK2 SLC4A11	1.18e-04	922	162	19	GO:0098662
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CACNA1B ATP13A4 BIN1 SLC5A10 TRPA1 ANK3 SLC38A5 DYSF RYR2 CBLIF CACNA2D4 SLC8B1 PPP3CA KCNH1 KCNN3 SLC26A11 SLC4A5 WNK4 WNK2 SLC4A11	1.46e-04	1017	162	20	GO:0098660
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1B ATP13A4 BIN1 SLC5A10 TRPA1 ANK3 SLC38A5 DYSF RYR2 CBLIF CACNA2D4 SLC8B1 PPP3CA KCNH1 KCNN3 SLC26A11 SLC4A5 WNK4 UNC80 WNK2 SLC4A11	1.79e-04	1115	162	21	GO:0034220
GeneOntologyBiologicalProcess	presynapse to nucleus signaling pathway	PCLO BSN	1.83e-04	3	162	2	GO:0099526
GeneOntologyBiologicalProcess	regulation of body fluid levels	CEACAM4 SRF MED1 TSPAN9 PPP3CA CELSR2 MLLT6 USF1 SLC4A5 NOS3 WNK4 IL6R	2.01e-04	442	162	12	GO:0050878
GeneOntologyCellularComponent	dendrite	CACNA1B BIN1 EPM2A ANK3 PCLO INSR SREBF2 PUM2 GRM4 TENM2 PPP3CA GABARAPL1 KCNH1 C4A C4B BSN INPP5J EPHA3	1.13e-04	858	161	18	GO:0030425
GeneOntologyCellularComponent	sarcolemma	COL6A3 BIN1 ANK3 DYSF RYR2 SLC8B1 PPP3CA NOS3	1.15e-04	190	161	8	GO:0042383
GeneOntologyCellularComponent	dendritic tree	CACNA1B BIN1 EPM2A ANK3 PCLO INSR SREBF2 PUM2 GRM4 TENM2 PPP3CA GABARAPL1 KCNH1 C4A C4B BSN INPP5J EPHA3	1.17e-04	860	161	18	GO:0097447
GeneOntologyCellularComponent	SREBP-SCAP-Insig complex	SREBF2 INSIG2	1.76e-04	3	161	2	GO:0032937
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1B BIN1 EPM2A ANK3 PCLO INSR SREBF2 PUM2 APOB GRM4 TENM2 PPP3CA GABARAPL1 KCNH1 KCNN3 C4A C4B BSN IL6R INPP5J EPHA3	4.98e-04	1228	161	21	GO:0036477
GeneOntologyCellularComponent	axon	CACNA1B BIN1 TRPA1 ANK3 PCLO INSR SH2D3C GRM4 TENM2 TENM3 KCNH1 MYPN C4A C4B BSN UNC80 INPP5J	5.30e-04	891	161	17	GO:0030424
Domain	Atg8	GABARAP GABARAPL1 GABARAPL3	3.22e-05	8	158	3	PF02991
Domain	Atg8-like	GABARAP GABARAPL1 GABARAPL3	3.22e-05	8	158	3	IPR004241
Domain	Znf_piccolo	PCLO BSN	7.11e-05	2	158	2	IPR008899
Domain	zf-piccolo	PCLO BSN	7.11e-05	2	158	2	PF05715
Domain	Rhs_assc_core	TENM2 TENM3	2.12e-04	3	158	2	IPR022385
Domain	Serpin_fam	NUP58 SERPINA11 SERPINA9 SERPINA5	3.22e-04	39	158	4	IPR000215
Domain	Tox-GHH_dom	TENM2 TENM3	4.22e-04	4	158	2	IPR028916
Domain	PPR	DENND4A DENND4C	4.22e-04	4	158	2	PF01535
Domain	Tox-GHH	TENM2 TENM3	4.22e-04	4	158	2	PF15636
Domain	Ten_N	TENM2 TENM3	4.22e-04	4	158	2	IPR009471
Domain	Ten_N	TENM2 TENM3	4.22e-04	4	158	2	PF06484
Domain	TENEURIN_N	TENM2 TENM3	4.22e-04	4	158	2	PS51361
Domain	Anaphylatoxin_comp_syst	C4A C4B	6.99e-04	5	158	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	6.99e-04	5	158	2	IPR001840
Domain	YD	TENM2 TENM3	6.99e-04	5	158	2	IPR006530
Domain	VWA	COL6A3 COL28A1 VWA7 PARP4 CACNA2D4	7.33e-04	84	158	5	SM00327
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOA6 TOB2 SYNPO2 ANK3 POM121C USF3 EGR1 KLF5 SETBP1 MLLT6 BSN SAP130 WNK4 WNK2 ZMYM5 GAREM1 SON	2.25e-11	430	162	17	35044719
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDC42BPG ANK3 UBE4B ERV3-1 SIPA1L3 INSR SREBF2 SRF ADGRG1 TSPAN9 SENP1 USF3 SLC8B1 LRFN2 PPP3CA GPR158 SETBP1 ELK3 ELK4 MBD5 SAP130 SLC4A5 TRAPPC9 GNL3 IL6R WNK2	6.50e-09	1489	162	26	28611215
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	NCOA6 INSR SREBF2 GPAM APOB MED1 PPP3CA KLF5 INSIG2 USF1 NOS3	2.92e-08	250	162	11	18660489
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 ZNF384 NCOA6 UBE4B SIPA1L3 AMBRA1 DYSF POM121C HDAC7 WDR59 CELSR1 SLC8B1 CELSR2 C19orf44 MLLT6 DTX2 MBD5 TRAPPC9 WNK2 GAREM1	2.44e-07	1105	162	20	35748872
Pubmed	Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.	GABARAP GABARAPL1 GABARAPL3	3.95e-07	4	162	3	11414770
Pubmed	A human MAP kinase interactome.	SYNPO2 ANK3 SREBF2 NUP58 POM121C USF3 EGR1 FHOD1 TNRC6A C4A MBD5 WNK2 GAREM1	5.18e-07	486	162	13	20936779
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MON2 TOB2 UBE4B PUM2 TENM2 RSBN1 LRFN2 TENM3 BAZ2A RABGAP1L ST18 SON	5.21e-07	407	162	12	12693553
Pubmed	The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid.	OPRPN C4A C4B	9.85e-07	5	162	3	21393236
Pubmed	Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).	SRF ELK3 ELK4	9.85e-07	5	162	3	7540136
Pubmed	Modulation of the antitumor immune response by complement.	OPRPN C4A C4B	1.96e-06	6	162	3	18820683
Pubmed	Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking.	OPRPN C4A C4B	3.42e-06	7	162	3	29233958
Pubmed	Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.	OPRPN C4A C4B	3.42e-06	7	162	3	14660741
Pubmed	Protective immune responses against West Nile virus are primed by distinct complement activation pathways.	OPRPN C4A C4B	3.42e-06	7	162	3	16651386
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	COL27A1 SIPA1L3 GPAM POM121C WDR59 PARP4 USF3 DTX2 MBD5 TRAPPC9 UNC80 ADAMTSL2	3.80e-06	493	162	12	15368895
Pubmed	Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.	BIN1 EGR1 C4A C4B	4.48e-06	24	162	4	11739537
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	COL6A3 BIN1 TSPAN9 CELSR1 RABGAP1L TRAPPC9 WNK2	4.90e-06	142	162	7	19851296
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	ZNF384 NCOA6 UBE4B GPATCH1 MED1 POM121C RSBN1 SENP1 BAZ2A SAP130	4.99e-06	341	162	10	32971831
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	COL6A3 BIN1 TSPAN9 CELSR1 RABGAP1L TRAPPC9 WNK2	5.13e-06	143	162	7	20198315
Pubmed	Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection.	OPRPN C4A C4B	5.46e-06	8	162	3	28301559
Pubmed	Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.	ANK3 GABARAP GABARAPL1	8.16e-06	9	162	3	29867141
Pubmed	Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.	OPRPN C4A C4B	8.16e-06	9	162	3	15905575
Pubmed	Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling.	OPRPN C4A C4B	1.16e-05	10	162	3	30429287
Pubmed	HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.	GABARAP AMBRA1 GABARAPL1	1.16e-05	10	162	3	30217973
Pubmed	The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity.	FCGR3A C4A C4B	2.12e-05	12	162	3	31801071
Pubmed	Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.	BIN1 DYSF RYR2	2.12e-05	12	162	3	23715556
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	2.16e-05	2	162	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	2.16e-05	2	162	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	2.16e-05	2	162	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	2.16e-05	2	162	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	2.16e-05	2	162	2	19933335
Pubmed	Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation.	PCLO BSN	2.16e-05	2	162	2	23403927
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	2.16e-05	2	162	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	2.16e-05	2	162	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	2.16e-05	2	162	2	12207352
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	2.16e-05	2	162	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	2.16e-05	2	162	2	22387014
Pubmed	Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone.	PCLO BSN	2.16e-05	2	162	2	26793095
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	2.16e-05	2	162	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	2.16e-05	2	162	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	2.16e-05	2	162	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	2.16e-05	2	162	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	2.16e-05	2	162	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	2.16e-05	2	162	2	6950384
Pubmed	Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.	PCLO BSN	2.16e-05	2	162	2	20332206
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	2.16e-05	2	162	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	2.16e-05	2	162	2	8428773
Pubmed	Alternative transcription initiation and splicing variants of the DHRS4 gene cluster.	DHRS4L2 DHRS4	2.16e-05	2	162	2	18754758
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	2.16e-05	2	162	2	24638111
Pubmed	Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner.	RUNX2 HDAC7	2.16e-05	2	162	2	17997710
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	2.16e-05	2	162	2	21345967
Pubmed	Active zone density is conserved during synaptic growth but impaired in aged mice.	PCLO BSN	2.16e-05	2	162	2	21935939
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	2.16e-05	2	162	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	2.16e-05	2	162	2	2302180
Pubmed	Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking.	CELSR1 CELSR2	2.16e-05	2	162	2	23292348
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	2.16e-05	2	162	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	2.16e-05	2	162	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	2.16e-05	2	162	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	2.16e-05	2	162	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	2.16e-05	2	162	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	2.16e-05	2	162	2	17728371
Pubmed	Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition.	SRF EGR1	2.16e-05	2	162	2	30365040
Pubmed	Structure and organization of the C4 genes.	C4A C4B	2.16e-05	2	162	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	2.16e-05	2	162	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	2.16e-05	2	162	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	2.16e-05	2	162	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	2.16e-05	2	162	2	2387317
Pubmed	Serum response factor binding sites differ in three human cell types.	SRF ELK4	2.16e-05	2	162	2	17200232
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	2.16e-05	2	162	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	2.16e-05	2	162	2	7365238
Pubmed	A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation.	SREBF2 APOB	2.16e-05	2	162	2	16455790
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	2.16e-05	2	162	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	2.16e-05	2	162	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	2.16e-05	2	162	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	2.16e-05	2	162	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	2.16e-05	2	162	2	6881182
Pubmed	Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology.	MUC16 MUC4	2.16e-05	2	162	2	23544943
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	2.16e-05	2	162	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	2.16e-05	2	162	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	2.16e-05	2	162	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	2.16e-05	2	162	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	2.16e-05	2	162	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	2.16e-05	2	162	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	2.16e-05	2	162	2	6832377
Pubmed	Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins.	INSR SREBF2	2.16e-05	2	162	2	24516236
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	2.16e-05	2	162	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	2.16e-05	2	162	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	2.16e-05	2	162	2	32691186
Pubmed	Deletion variants of RABGAP1L, 10q21.3, and C4 are associated with the risk of systemic lupus erythematosus in Korean women.	RABGAP1L C4A	2.16e-05	2	162	2	23335107
Pubmed	Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.	PCLO BSN	2.16e-05	2	162	2	25652077
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	2.16e-05	2	162	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	2.16e-05	2	162	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	2.16e-05	2	162	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	2.16e-05	2	162	2	3696167
Pubmed	The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.	SRF ELK4	2.16e-05	2	162	2	11406578
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	2.16e-05	2	162	2	1357031
Pubmed	CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics.	DHRS4L2 DHRS4	2.16e-05	2	162	2	15473316
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	2.16e-05	2	162	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	2.16e-05	2	162	2	15787745
Pubmed	Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels.	APOB INSIG2	2.16e-05	2	162	2	20858904
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	2.16e-05	2	162	2	30026462
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR2	1.18e-04	3	114	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR2	1.18e-04	3	114	2	1189
GeneFamily	CD molecules\|Mucins	MUC16 MUC4 MUC7	2.99e-04	21	114	3	648
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.38e-03	9	114	2	1234
GeneFamily	Serpin peptidase inhibitors	SERPINA11 SERPINA9 SERPINA5	1.62e-03	37	114	3	739
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2A MBD5	2.09e-03	11	114	2	1025
GeneFamily	Collagens	COL6A3 COL28A1 COL27A1	3.04e-03	46	114	3	490
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PCLO BSN	3.92e-03	15	114	2	26
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	INSR RUNX2 PRDM8 CELSR1 EGR1 DTX2 MUC4 WNK2 GAREM1	3.24e-08	190	161	9	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	ANK3 DYSF TENM2 RBM20 TSPAN9 RYR2 RABGAP1L MYPN WNK2	3.39e-08	191	161	9	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	facs-Aorta-Heart-3m-Endothelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.06e-08	195	161	9	8493f2f60fc356af28b9c0e287d4cd8c8899c081
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 MUC16 CELSR1 DMRT3 KLF5 DTX2 MUC4 WNK2 SLC4A11	4.06e-08	195	161	9	e7230a849ea31e6eef9bc6f5468938499450582d
ToppCell	facs-Aorta-Heart-3m-Endothelial-aortic_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.06e-08	195	161	9	5e5ca7bd94c9e924ed76f7ccac199be745d4c4eb
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MON2 ANK3 SIPA1L3 AMBRA1 INO80D RABGAP1L TNRC6A MBD5 TRAPPC9	4.83e-08	199	161	9	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 PCLO SREBF2 MUC16 CELSR1 KLF5 DTX2 WNK2 GAREM1	5.04e-08	200	161	9	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ANK3 PCLO MUC16 ADGRG1 CCDC80 CELSR1 KLF5 MUC4 PLXNB1	5.04e-08	200	161	9	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Control-Epithelial_alveolar-Mes-Like\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 PROSER1 RBM20 SPAG5 STAB1 SPATC1 WNK2	2.22e-07	116	161	7	df7609503782d8d7e4f31ed2a626916e5474d5bc
ToppCell	droplet-Trachea-nan-3m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	3.70e-07	184	161	8	fa5c3020e75fdde1363393dea97ebd99f1eae9ff
ToppCell	droplet-Trachea-3m-Endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	3.70e-07	184	161	8	ad520ab6bb776b5303df505b7e1afb22484f18a7
ToppCell	droplet-Trachea-nan-3m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	3.70e-07	184	161	8	1d63cb75a89c5f3f3b9ebf7fce8cb0fd4a92b645
ToppCell	droplet-Trachea-nan-3m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	3.70e-07	184	161	8	76caad53d55fff5acca27bf190a6de7b27437d9f
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	3.70e-07	184	161	8	1fc1f0a3b4dbb085ebcc3960f67be24a108fe5b9
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	3.70e-07	184	161	8	2467207aaea307873ab286f89cfc7668a227a694
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	INSR PRDM8 CELSR1 EGR1 MUC4 WNK2 EBF4 GAREM1	4.18e-07	187	161	8	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	ANK3 DYSF RBM20 TSPAN9 RYR2 RABGAP1L MYPN WNK2	4.36e-07	188	161	8	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.53e-07	189	161	8	ecbe079606406f47d4fc97fe1670790dda8e10de
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	ATP13A4 ANK3 INSR CELSR1 KLF5 MUC4 WNK2 GAREM1	4.53e-07	189	161	8	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.53e-07	189	161	8	e830fa0ddc3dccfaf9e88e8c416ed6aab12e3e3f
ToppCell	facs-Trachea-18m-Endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.53e-07	189	161	8	f635f3f13bced3bcf796cf55723a2df851f973fe
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	INSR SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	4.53e-07	189	161	8	28b9e96a5206b7fdae9b17daf05c8f5d24b6c5ec
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.72e-07	190	161	8	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.72e-07	190	161	8	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.72e-07	190	161	8	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	SYNPO2 ANK3 TENM2 RBM20 RYR2 RABGAP1L MYPN WNK2	4.91e-07	191	161	8	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.91e-07	191	161	8	79b399496bd7322a1d53c43378f48695fd09a5d9
ToppCell	facs-Trachea-24m-Endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.91e-07	191	161	8	9c6d5d045781c6506ae80e318427ef1e0d87f45c
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR ELK3 NOS3	4.91e-07	191	161	8	1b1e943709d0c3283a980c7c965ef1f110506a29
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO DENND4C TENM3 GPR158 KCNN3 MUC4 ST18 UNC80	5.11e-07	192	161	8	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 INSR TSPAN9 RABGAP1L SETBP1 TNRC6A MBD5 TRAPPC9	5.11e-07	192	161	8	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	15\|World / Age, Tissue, Lineage and Cell class	INSR DHRS4 PPP3CA EGR1 KLF5 DLEC1 USF1 MUC4	5.31e-07	193	161	8	a8ad0de955494d6f5929dc44ba46627d06d95453
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	INSR SH2D3C DYSF RYR2 ECSCR KCNN3 ELK3 NOS3	5.53e-07	194	161	8	a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	ATP13A4 ANK3 SIPA1L3 AMBRA1 RABGAP1L MBD5 TRAPPC9 GAREM1	5.97e-07	196	161	8	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B PCLO TENM2 RYR2 GPR158 KCNH1 SETBP1 UNC80	5.97e-07	196	161	8	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 CCDC80 VWA7 HDAC7 TSPAN9 STAB1 ECSCR ELK3	5.97e-07	196	161	8	81900dcc9451ff6606ec940c16b559d73247590e
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ATP13A4 ANK3 INSR RUNX2 CELSR1 DTX2 MUC4 WNK2	6.45e-07	198	161	8	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	INSR SH2D3C SLC38A5 DYSF ECSCR NOS3 SERPINA5 ADAMTSL2	6.45e-07	198	161	8	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 ANK3 PCLO SREBF2 RUNX2 PRDM8 CELSR1 WNK2	6.45e-07	198	161	8	6ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	INSR MUC16 RUNX2 PRDM8 DTX2 MUC4 WNK2 SLC4A11	6.45e-07	198	161	8	fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	INSR MUC16 RUNX2 PRDM8 DTX2 MUC4 WNK2 SLC4A11	6.95e-07	200	161	8	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1B ANK3 PCLO TENM2 RYR2 KCNH1 SETBP1 UNC80	6.95e-07	200	161	8	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	COVID-19_Mild\|World / 5 Neutrophil clusters in COVID-19 patients	ANK3 ADGRG1 NUP58 CELSR1 USF3 FCGR3A CCDC158	1.38e-06	152	161	7	2ff0980dfd8d430cca14649151d856edef115720
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	FAM184A COL28A1 PCLO MUC16 RBM20 CFAP65 PLXNB1	1.64e-06	156	161	7	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	INSR MUC16 CELSR1 KLF5 DTX2 MUC4 WNK2	2.02e-06	161	161	7	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A3 COL27A1 LGR4 CCDC80 TENM3 WNK4 EBF4	2.48e-06	166	161	7	37794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	VWA7 INO80D USF3 C19orf44 MBD5 PLXNB1 SON	2.48e-06	166	161	7	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A3 COL27A1 LGR4 CCDC80 TENM3 WNK4 EBF4	2.48e-06	166	161	7	81c546c6d847e49e662b81e71992ca0f7a99e890
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A PCLO SREBF2 DENND4C GPR158 BSN MUC4	3.39e-06	174	161	7	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ATP13A4 PCLO MUC16 CELSR2 KLF5 MUC4 WNK2	3.39e-06	174	161	7	9e5fae9ecc7c0111fc8a252e72b89dc89c0d3a7c
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 ANK3 SREBF2 RUNX2 CELSR1 MUC4 WNK2	3.65e-06	176	161	7	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPM2A PCLO DENND4C GPR158 BSN MUC4 ST18	3.94e-06	178	161	7	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	(3)_Chondrocytes-(32)_Chondro-prehyper-2\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	CCDC80 RUNX2 TENM2 SLC22A17 AGMO INSIG2 WNK4	4.24e-06	180	161	7	708a5c89b9337e281fce4f482892a1c1766c7812
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-Resting_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PCDHGA5 COL27A1 TENM3 KLF5 SLC26A11 WNK4 WNK2	4.56e-06	182	161	7	00a148b1e499bf16325491536d187d4dd6b70c06
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 CELSR2 CLDN19 WNK4 UNC80 WNK2 PLXNB1	4.56e-06	182	161	7	c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCell	Epithelial-lung_goblet_cell\|World / Lineage, Cell type, age group and donor	INSR MUC16 CELSR1 DTX2 MUC4 WNK2 SLC4A11	4.72e-06	183	161	7	940cbe298e9c53b5622af09264586ed823d3141f
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SIPA1L3 SLC38A5 ADGRG1 NUP58 SENP1 USF3 ATAD2B	4.90e-06	184	161	7	e6bf826be31e1723e24c366fc5a1cee9b15589bc
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	SYNPO2 ANK3 TENM2 RBM20 RYR2 RABGAP1L MYPN	4.90e-06	184	161	7	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	facs-Trachea-nan-24m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	5.07e-06	185	161	7	dec60254204014083ff3b4aec0cc75410950a486
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	SYNPO2 ANK3 TENM2 RBM20 RYR2 RABGAP1L MYPN	5.07e-06	185	161	7	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	facs-Trachea-nan-24m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	5.07e-06	185	161	7	201465dc0d7aa0336a36d37805cae1155a5adfe1
ToppCell	facs-Trachea-nan-24m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF TSPAN9 STAB1 ECSCR NOS3	5.07e-06	185	161	7	334f006c3ef33338ff8d649309d3f448733a3a99
ToppCell	droplet-Heart-nan-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF STAB1 ECSCR ELK3 NOS3	5.07e-06	185	161	7	a32d5cb596ebac80eb1ac301055e65d420879ec8
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDC42BPG SRF TENM2 CELSR1 CELSR2 EGR1 KLF5	5.26e-06	186	161	7	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 RBM20 RYR2 GABARAPL1 CLDN19 WNK4 INPP5J	5.26e-06	186	161	7	8eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL6A3 SYNPO2 COL27A1 INSR TENM3 SETBP1 ADAMTSL2	5.44e-06	187	161	7	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	COL6A3 COL27A1 RYR2 EGR1 FHOD1 SETBP1 ADAMTSL2	5.44e-06	187	161	7	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	COL27A1 LGR4 GPAM WDR59 TNRC6A MBD5 WNK2	5.44e-06	187	161	7	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	COVID-19-Epithelial_cells-Airway_basal\|COVID-19 / group, cell type (main and fine annotations)	ATP13A4 ANK3 LGR4 CELSR1 KLF5 MUC4 PLXNB1	5.44e-06	187	161	7	8407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCell	P15-Mesenchymal\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL6A3 SLC38A5 CCDC80 EGR1 SPON2 IL6R ADAMTSL2	5.64e-06	188	161	7	f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO TENM2 TENM3 EGR1 IL6R UNC80 SON	5.64e-06	188	161	7	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SREBF2 LGR4 EGR1 SETBP1 KCNN3 MBD5 TRAPPC9	6.04e-06	190	161	7	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	COL6A3 SYNPO2 CCDC80 RYR2 TENM3 SETBP1 EPHA3	6.04e-06	190	161	7	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO EGR1 TNRC6A ST18 IL6R UNC80 SON	6.25e-06	191	161	7	fd01a206763dfb6d52cca67123571936b4a8e1a0
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ATP13A4 ANK3 CELSR1 EGR1 MUC4 WNK2 GAREM1	6.25e-06	191	161	7	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SYNPO2 CCDC80 RBM20 RYR2 SETBP1 EPHA3	6.25e-06	191	161	7	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	PND28-Mesenchymal-Mesenchymal_structural\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A3 SLC38A5 CCDC80 EGR1 SPON2 C4B ADAMTSL2	6.69e-06	193	161	7	ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	ATP13A4 ANK3 SREBF2 CELSR1 MUC4 WNK2 GAREM1	6.69e-06	193	161	7	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	COL27A1 LGR4 GPAM WDR59 TSPAN9 TNRC6A WNK2	6.69e-06	193	161	7	503a979328c68b096680b71359a26f02fafdff35
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A3 SLC38A5 CCDC80 EGR1 SPON2 C4B ADAMTSL2	6.69e-06	193	161	7	30481fb01c7acf85beae10213f038da86bed6777
ToppCell	Control-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 PROSER1 RBM20 SPAG5 SPATC1 WNK2	6.92e-06	127	161	6	556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A3 TENM2 RYR2 FHOD1 SETBP1 AGMO ADAMTSL2	6.92e-06	194	161	7	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SYNPO2 CCDC80 RUNX2 TENM3 SETBP1 ADAMTSL2	6.92e-06	194	161	7	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	ANK3 TENM2 RBM20 RYR2 RABGAP1L MYPN WNK2	6.92e-06	194	161	7	c3535f7cc0076653c72db582047cff053c322397
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 DMRT3 KCNH1 ST18 UNC80 WNK2 SLC4A11	6.92e-06	194	161	7	2dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO TENM2 DENND4C TENM3 GPR158 MUC4 UNC80	7.16e-06	195	161	7	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	ANK3 INSR TENM2 RBM20 RYR2 MYPN WNK2	7.16e-06	195	161	7	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	Epithelial_cells-Club_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	MUC16 CCDC80 RUNX2 DTX2 MUC4 WNK2 SLC4A11	7.16e-06	195	161	7	b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ATP13A4 ANK3 COL28A1 SREBF2 CELSR1 EGR1 WNK2	7.16e-06	195	161	7	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAM184A ANK3 LGR4 ADGRG1 CLDN19 SERPINA5 WNK4	7.16e-06	195	161	7	3123e02d2894c83962ba402085b5e6422ebf8c73
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 HDAC7 STAB1 ECSCR ELK3 NOS3	7.16e-06	195	161	7	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	facs-GAT-Fat-3m-Endothelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF STAB1 ECSCR ELK3 NOS3	7.40e-06	196	161	7	b6cc1f466d45479764080d34b1daeb8243a5a9f3
ToppCell	facs-GAT-Fat-3m-Endothelial-endothelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF STAB1 ECSCR ELK3 NOS3	7.40e-06	196	161	7	ede6104cdfa4ee5287efcca9bbc36677cbf7a8d8
ToppCell	facs-GAT-Fat-3m-Endothelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C ADGRG1 DYSF STAB1 ECSCR ELK3 NOS3	7.40e-06	196	161	7	039044ab28c53391c34d8226fb8cf78549e63ef4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 ADGRG1 GABARAPL1 SERPINA5 WNK4 INPP5J PLXNB1	7.40e-06	196	161	7	f40d10ea7714067585493fdc89744714aa427de8
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 ADGRG1 GABARAPL1 SERPINA5 WNK4 INPP5J PLXNB1	7.40e-06	196	161	7	b8350340d86e4524e9616a427e7f2e116a6fb3be
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SYNPO2 CCDC80 RUNX2 TENM3 SETBP1 ADAMTSL2	7.65e-06	197	161	7	ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SYNPO2 CCDC80 RUNX2 TENM3 SETBP1 ADAMTSL2	7.65e-06	197	161	7	37f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell	Parenchyma_Control_(B.)-Immune-TX-MoAM-4\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	ZNF384 BIN1 SRF RUNX2 TTBK2 SLC26A11 IL6R	7.65e-06	197	161	7	dc1c55e3aacc9d60d0f111c2f20f150ca296f011
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ATP13A4 ANK3 CELSR1 FHOD1 PLXNB1 SLC4A11 SON	7.65e-06	197	161	7	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
Drug	epps	CACNA1B EPM2A UBE4B KCNH1 BSN	8.42e-06	40	159	5	CID000085255
Drug	Scoulerine [6451-73-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	TRPA1 ADGRG1 EXTL1 INO80D HDAC7 CBLIF BAZ2A ST18 INPP5J	1.10e-05	198	159	9	2891_UP
Drug	Hexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; HL60; HT_HG-U133A	SIPA1L3 INSR APOB BFSP1 CHST8 SPON2 SETBP1 MAGEC1 ZMYM5	1.10e-05	198	159	9	2708_UP
Drug	Isoniazid [54-85-3]; Up 200; 29.2uM; PC3; HT_HG-U133A	EPM2A PCLO TTLL5 APOB CBLIF EGR1 INPP5J PLXNB1 ZMYM5	1.10e-05	198	159	9	2083_UP
Disease	kallistatin measurement	SERPINA11 SERPINA9 SERPINA5	7.66e-06	8	154	3	EFO_0008196
Disease	Paroxysmal atrial fibrillation	UBE4B RBM20 MYPN KCNN3 MBD5 NOS3 EPHA3	1.87e-05	156	154	7	C0235480
Disease	familial atrial fibrillation	UBE4B RBM20 MYPN KCNN3 MBD5 NOS3 EPHA3	1.87e-05	156	154	7	C3468561
Disease	Persistent atrial fibrillation	UBE4B RBM20 MYPN KCNN3 MBD5 NOS3 EPHA3	1.87e-05	156	154	7	C2585653
Disease	Atrial Fibrillation	UBE4B RBM20 MYPN KCNN3 MBD5 NOS3 EPHA3	2.20e-05	160	154	7	C0004238
Disease	Zimmerman Laband syndrome	KCNH1 KCNN3	8.09e-05	3	154	2	C0796013
Disease	serpin A9 measurement	SERPINA11 SERPINA9	1.61e-04	4	154	2	EFO_0802062
Disease	Portal Hypertension	KCNN3 NOS3	2.68e-04	5	154	2	C0020541
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK4 WNK2	4.00e-04	6	154	2	DOID:4479 (implicated_via_orthology)
Disease	coronary artery disease	COL6A3 NCOA6 APOB RUNX2 TSPAN9 RSBN1 PRDM8 SENP1 LRFN2 CELSR2 DLEC1 BSN SAP130 NOS3 IL6R WNK2	5.31e-04	1194	154	16	EFO_0001645
Disease	LDL cholesterol change measurement	APOB CELSR2	5.59e-04	7	154	2	EFO_0007804
Disease	anxiety, smoking behaviour measurement	PRDM8 UNC80	5.59e-04	7	154	2	EFO_0005230, EFO_0005671
Disease	psychotic symptoms	ANK3 CATSPERD COL28A1 ST18	6.18e-04	74	154	4	EFO_0005940
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	APOB CELSR2	7.42e-04	8	154	2	EFO_0008589, EFO_0008595
Disease	common bile duct neoplasm (is_marker_for)	APOB MUC4	7.42e-04	8	154	2	DOID:4608 (is_marker_for)
Disease	vital capacity	COL6A3 NCOA6 PCLO LGR4 APOB RUNX2 MED1 TENM2 RBM20 TSPAN9 RYR2 SENP1 ATAD2B MYPN AGMO EPHA3	7.68e-04	1236	154	16	EFO_0004312
Disease	ascending aortic diameter	COL6A3 RYR2 PRDM8 MBD5 TRAPPC9	8.59e-04	140	154	5	EFO_0021787
Disease	Bipolar Disorder	CACNA1B ANK3 PCLO GRM4 STAB1 CBLIF KCNN3 MBD5 NOS3	9.39e-04	477	154	9	C0005586
Disease	alpha-1-antitrypsin measurement	CELSR2 SERPINA5	9.51e-04	9	154	2	EFO_0008327
Disease	pulse pressure measurement	COL6A3 COL27A1 INSR GRM4 DYSF SLC22A17 DENND4C PRDM8 SENP1 PPP3CA ATAD2B MYPN TNRC6A DLEC1 MBD5 ST18 TRAPPC9	9.98e-04	1392	154	17	EFO_0005763
Disease	diabetic nephropathy	SH2D3C CCDC80 GPR158 AGMO MUC7	1.17e-03	150	154	5	EFO_0000401
Disease	unipolar depression, bipolar disorder	ATP13A4 ANK3 PCLO TENM2 SETBP1	1.39e-03	156	154	5	EFO_0003761, MONDO_0004985
Disease	Tachycardia, Ventricular	RYR2 NOS3	1.44e-03	11	154	2	C0042514
Disease	smoking cessation	ANK3 TENM2 RABGAP1L ATAD2B TNRC6A BSN ADAMTSL2	1.65e-03	325	154	7	EFO_0004319
Disease	lymphangioleiomyomatosis (is_marker_for)	SRF NOS3	1.73e-03	12	154	2	DOID:3319 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	GPAM APOB CELSR2 INSIG2	1.83e-03	99	154	4	EFO_0004611, EFO_0007878
Disease	Osteosarcoma	RUNX2 GRM4 KCNH1	1.91e-03	47	154	3	C0029463
Disease	interleukin 6 receptor subunit alpha measurement	KCNN3 IL6R	2.03e-03	13	154	2	EFO_0008187
Disease	Fetal Alcohol Spectrum Disorders	ANK3 SRF	2.03e-03	13	154	2	C2985290
Disease	brain cortex volume measurement	COL6A3 RUNX2	2.03e-03	13	154	2	EFO_0010287
Disease	frontotemporal dementia, age at onset	COL28A1 ST18	2.03e-03	13	154	2	EFO_0004847, MONDO_0017276
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	GPAM APOB CELSR2 INSIG2	2.04e-03	102	154	4	EFO_0004329, EFO_0004611
Disease	creatinine measurement	SIPA1L3 MED1 TSPAN9 PRDM8 PPP3CA CELSR2 SETBP1 MYPN DLEC1 BSN MBD5 UNC80 CCDC158	2.22e-03	995	154	13	EFO_0004518
Disease	Tourette syndrome	COL27A1 MUC16 TENM2	2.28e-03	50	154	3	EFO_0004895
Disease	CD209 antigen measurement	CELSR2 ADAMTSL2	2.36e-03	14	154	2	EFO_0008077
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	APOB CELSR2	2.36e-03	14	154	2	EFO_0004611, EFO_0008589
Disease	diabetic neuropathy (implicated_via_orthology)	TRPA1 INSR	2.36e-03	14	154	2	DOID:9743 (implicated_via_orthology)
Disease	Schizophrenia	CACNA1B ANK3 SREBF2 GABARAP AMBRA1 GRM4 CFAP65 CBLIF KLF5 KCNN3 MAGEC1 IL6R	2.38e-03	883	154	12	C0036341
Disease	myocardial infarction	COL6A3 APOB PRDM8 CELSR2 TENM3 NOS3 IL6R	2.50e-03	350	154	7	EFO_0000612
Disease	anti-neutrophil antibody associated vasculitis	SERPINA11 RSBN1 SERPINA9	2.55e-03	52	154	3	EFO_0004826
Disease	total phospholipids in lipoprotein particles measurement	GPAM APOB CELSR2	2.70e-03	53	154	3	EFO_0022315
Disease	Hypertriglyceridemia	APOB CELSR2	2.72e-03	15	154	2	C0020557
Disease	response to statin, LDL cholesterol change measurement	APOB CELSR2	2.72e-03	15	154	2	EFO_0007804, GO_0036273
Disease	anemia (implicated_via_orthology)	SLC4A5 SLC4A11	2.72e-03	15	154	2	DOID:2355 (implicated_via_orthology)
Disease	coronary artery disease, factor VII measurement	APOB PRDM8 CELSR2 NOS3	2.77e-03	111	154	4	EFO_0001645, EFO_0004619
Disease	factor VIII measurement, coronary artery disease	APOB PRDM8 CELSR2 NOS3	2.96e-03	113	154	4	EFO_0001645, EFO_0004630
Disease	phospholipids in medium HDL measurement	GPAM APOB CELSR2	3.00e-03	55	154	3	EFO_0022295
Disease	Beta blocking agent use measurement	INSR PRDM8 CELSR2 NOS3	3.05e-03	114	154	4	EFO_0009929
Disease	diabetic retinopathy (implicated_via_orthology)	INSR NOS3	3.10e-03	16	154	2	DOID:8947 (implicated_via_orthology)
Disease	sickle cell anemia (is_implicated_in)	APOB NOS3	3.10e-03	16	154	2	DOID:10923 (is_implicated_in)
Disease	ovarian cancer (is_implicated_in)	MUC16 APOB NOS3	3.16e-03	56	154	3	DOID:2394 (is_implicated_in)
Disease	free cholesterol to total lipids in large HDL percentage	GPAM APOB CELSR2	3.16e-03	56	154	3	EFO_0022279
Disease	HMG CoA reductase inhibitor use measurement	APOB DENND4C PRDM8 CELSR2 NOS3	3.20e-03	189	154	5	EFO_0009932
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	GPAM APOB SERPINA11 LRFN2 CELSR2 SERPINA9	3.25e-03	274	154	6	EFO_0004530, EFO_0004612
Disease	atrial fibrillation	UBE4B RBM20 PRDM8 KCNN3 MBD5 IL6R EPHA3	3.44e-03	371	154	7	EFO_0000275
Disease	von Willebrand factor measurement, coronary artery disease	APOB PRDM8 CELSR2 NOS3	3.45e-03	118	154	4	EFO_0001645, EFO_0004629
Disease	cholesterol in IDL measurement	GPAM APOB CELSR2	3.49e-03	58	154	3	EFO_0021899
Disease	total lipids in medium HDL measurement	GPAM APOB CELSR2	3.49e-03	58	154	3	EFO_0022310
Disease	response to radiation, Urinary retention	COL6A3 AGMO	3.50e-03	17	154	2	GO_0009314, HP_0000016
Disease	muscular dystrophy (is_implicated_in)	COL6A3 DYSF	3.50e-03	17	154	2	DOID:9884 (is_implicated_in)
Disease	Uremia	RUNX2 NOS3	3.50e-03	17	154	2	C0041948
Disease	Lipidemias	APOB NOS3	3.50e-03	17	154	2	C1706412
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	APOB CELSR2	3.50e-03	17	154	2	EFO_0022232
Disease	Familial Progressive Myoclonic Epilepsy	EPM2A PRDM8	3.50e-03	17	154	2	C0751777
Disease	Atypical Inclusion-Body Disease	EPM2A PRDM8	3.50e-03	17	154	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	EPM2A PRDM8	3.50e-03	17	154	2	C0751778
Disease	Biotin-Responsive Encephalopathy	EPM2A PRDM8	3.50e-03	17	154	2	C0751780
Disease	May-White Syndrome	EPM2A PRDM8	3.50e-03	17	154	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	EPM2A PRDM8	3.50e-03	17	154	2	C0751781
Disease	Fetal Alcohol Syndrome	ANK3 SRF	3.50e-03	17	154	2	C0015923
Disease	Hyperlipidemia	APOB NOS3	3.50e-03	17	154	2	C0020473
Disease	ferritin measurement	STAB1 NKX1-2 TENM3 GNL3	3.56e-03	119	154	4	EFO_0004459
Disease	cholesterol in medium HDL measurement	GPAM APOB CELSR2	3.66e-03	59	154	3	EFO_0021903
Disease	total lipids in IDL	GPAM APOB CELSR2	3.84e-03	60	154	3	EFO_0022161
Disease	Insulin Resistance	INSR SREBF2 NOS3	3.84e-03	60	154	3	C0021655
Disease	Insulin Sensitivity	INSR SREBF2 NOS3	3.84e-03	60	154	3	C0920563
Disease	free cholesterol to total lipids in medium HDL percentage	GPAM APOB CELSR2	3.84e-03	60	154	3	EFO_0022282
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	APOB CELSR2	3.92e-03	18	154	2	EFO_0008317, EFO_0008589
Disease	Action Myoclonus-Renal Failure Syndrome	EPM2A PRDM8	3.92e-03	18	154	2	C0751779
Disease	Hypercholesterolemia, Familial	SREBF2 APOB	3.92e-03	18	154	2	C0020445
Disease	free cholesterol in IDL measurement	GPAM APOB CELSR2	4.02e-03	61	154	3	EFO_0022181
Disease	response to opioid	MUC16 CACNA2D4 ADAMTSL2	4.02e-03	61	154	3	EFO_0008541
Disease	phospholipids in HDL measurement	GPAM APOB CELSR2	4.02e-03	61	154	3	EFO_0022293
Disease	systemic lupus erythematosus (is_implicated_in)	FCGR3A C4A C4B	4.21e-03	62	154	3	DOID:9074 (is_implicated_in)
Disease	free cholesterol in very large HDL measurement	GPAM APOB CELSR2	4.21e-03	62	154	3	EFO_0022273
Disease	angina pectoris	APOB PRDM8 CELSR2 IL6R	4.24e-03	125	154	4	EFO_0003913
Disease	cardiomyopathy (is_implicated_in)	SRF NOS3	4.37e-03	19	154	2	DOID:0050700 (is_implicated_in)
Disease	sodium-coupled monocarboxylate transporter 1 measurement	APOB CELSR2	4.37e-03	19	154	2	EFO_0802076
Disease	triglycerides to total lipids in IDL percentage	GPAM APOB CELSR2	4.40e-03	63	154	3	EFO_0022329
Disease	cholangiocarcinoma (is_marker_for)	MUC16 PPP3CA MUC4	4.60e-03	64	154	3	DOID:4947 (is_marker_for)
Disease	prostate adenocarcinoma (is_implicated_in)	BIN1 INSR	4.83e-03	20	154	2	DOID:2526 (is_implicated_in)
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	TTLL5 DYSF STAB1 EGR1	5.01e-03	131	154	4	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	TTLL5 DYSF STAB1 EGR1	5.01e-03	131	154	4	C4552091
Disease	Juvenile arthritis	TTLL5 DYSF STAB1 EGR1	5.01e-03	131	154	4	C3495559
Disease	Juvenile psoriatic arthritis	TTLL5 DYSF STAB1 EGR1	5.01e-03	131	154	4	C3714758
Disease	total lipids in very large HDL measurement	GPAM APOB CELSR2	5.02e-03	66	154	3	EFO_0022312

Protein segments in the cluster

Peptide	Gene	Start	Entry
NFTLTASSLEPAPSS	ERV3-1	316	Q14264
VLSFFPTAPASRASA	EPM2A	251	B3EWF7
SPISSLPALFDQTAS	MLLT6	671	P55198
VAAVSSVSPATPFQS	BRD3	171	Q15059
FFLPASLSANNTPTR	CDC23	571	Q9UJX2
PTTVQFTIEALPSSA	CEACAM4	31	O75871
DNFETSLLPFTIPTS	CATSPERD	76	Q86XM0
PVAFSVVPTAATAVS	C4B	896	P0C0L5
PLVPSLSSAFEIVFS	AGMO	411	Q6ZNB7
ASFCQPETVPTSFVS	ATP13A4	631	Q4VNC1
FSVVSPASSAVLPAV	BAZ2A	466	Q9UIF9
PRFISPASQLAITFS	GRM4	691	Q14833
ATLVTQEFFNPSTPV	CLDN19	141	Q8N6F1
SSAPFLSSTTVLFRP	CELSR1	1326	Q9NYQ6
SSAPFIASSSVLFRP	CELSR2	1251	Q9HCU4
PASARATTPSFSFVQ	AMBRA1	331	Q9C0C7
IVSSIAAFSPSPGFS	DHRS4	166	Q9BTZ2
TPTTNFDTFPAAILT	CACNA1B	641	Q00975
TFLSPAQSEASPVAS	FAM184A	1111	Q8NB25
ATSLESFTNAPPTTI	CCDC80	436	Q76M96
PLPVFSTFVLTGASA	DENND4A	251	Q7Z401
AAAIPSTRFPSNAIA	RBM20	156	Q5T481
QSSPTFPLASVGTTF	RBM20	496	Q5T481
QPPLSATFTVTVAVA	PCDHGA5	651	Q9Y5G8
PTPVLISSAAAQAAA	PUM2	466	Q8TB72
AVFPRAPTANTASTE	CDC42BPG	856	Q6DT37
LFTLVPTAFSSSVPA	NXF3	506	Q9H4D5
SAAPTTSPIVLTASF	MUC16	2321	Q8WXI7
PQSTLTFEFSEVPSL	MUC16	2886	Q8WXI7
PNTPLSTFLFDSLST	MUC16	3721	Q8WXI7
FPASTVFPQVSETTA	MUC16	11786	Q8WXI7
ISNATPLPVTYASSA	MUC4	971	Q99102
FSTPVPADSTSLLVS	FAM189A1	331	O60320
IVSSIAAFSPSPGFS	DHRS4L2	166	Q6PKH6
LSIFQSSPESTQSPF	MAGEC1	141	O60732
PVSPSFSSTLVSLFQ	MAGEC1	271	O60732
ASTNATIPITTTPFA	MGAM2	1971	Q2M2H8
SPSLVQVYTSPAAVA	DTX2	6	Q86UW9
ITFSTDSLSAPAPQV	GPR158	176	Q5T848
QDIPSFSPIFLLSTS	ATAD2B	856	Q9ULI0
VENPSVSFASSFPLI	CFAP65	16	Q6ZU64
VVSASRSPASVFPAF	KIAA2026	2076	Q5HYC2
LPTIPSASDFNTVLS	KIAA1109	2386	Q2LD37
TTQSTLFPVPADSRA	BSN	3126	Q9UPA5
VSPSRSFPIFQILTS	C9orf131	161	Q5VYM1
FPAQVSSFPSSAVTN	EGR1	506	P18146
SVFNFLTLPETASLP	GPATCH1	646	Q9BRR8
ASPVTTATPLFDAVT	PCLO	2446	Q9Y6V0
PSSFQAAPTSVTQFL	PCLO	2656	Q9Y6V0
EVLFAAFSSAAPPTV	PLXNB1	291	O43157
TAFRAPPSSNSTAIL	KCNN3	106	Q9UGI6
LLASPTSPVTAEFSS	GAREM1	676	Q9H706
RESPATPVSFQAAST	KCNH1	791	O95259
SSEAPFPNVSTSLLT	ADAMTSL2	526	Q86TH1
FSFAPLITAISISPE	LGR4	766	Q9BXB1
LFFFVNNVIPPTSAT	GABARAP	76	O95166
TVAVPTVAAFPNTSS	INSR	771	P06213
AISVPISSDASPFIL	MON2	1306	Q7Z3U7
PTVLSIFLFNAPETS	OR51A2	81	Q8NGJ7
STSSFFPILAPAVGS	PARP4	1311	Q9UKK3
TLFPPDVIASIFSSA	INSIG2	56	Q9Y5U4
IPTPDSDVFTFSVSL	RABGAP1L	266	Q5R372
RQALTFFLDITSPPS	NOS3	856	P29474
SEAISSSSIPQFPIT	PASD1	661	Q8IV76
TQPSFTFTLPAAATA	POM121C	546	A8CG34
APVFTALPSFTSLTN	PROSER1	691	Q86XN7
ALPSFTSLTNNFPLT	PROSER1	696	Q86XN7
PFTALPTDTAISVTF	OR4D9	261	Q8NGE8
ARPQFITPVFINSSS	NCOA6	1651	Q14686
VATTQIPSVTFPSAS	MUC7	106	Q8TAX7
SLVFSVSFPPQLSVR	PUS10	141	Q3MIT2
IPSRFSTPEFTILNT	APOB	2641	P04114
SVTSSAYPNPSILIA	CBLIF	46	P27352
VQDSSSVPLPTFLVA	IL6R	356	P08887
LQFSSSVQIDPPFSS	COL28A1	96	Q2UY09
LFFFVNNTIPPTSAT	GABARAPL1	76	Q9H0R8
ASLTPAFFSQTPIIL	ELK4	351	P28324
AAAPTTSVFSFSPVN	EBF4	531	Q9BQW3
RFSADSSNVVPSPLA	DMRT3	341	Q9NQL9
FPSNSTSVFRSSPVL	DMRT3	411	Q9NQL9
AQPLVSPISAFLTAT	CACNA2D4	951	Q7Z3S7
LFSVPSQLRAFTVPS	C19orf44	251	Q9H6X5
TSAFIETPIPLFTQS	BFSP1	321	Q12934
LASAAPSQSIFFSPV	SERPINA5	56	P05154
VAVFFSNTPTRASPQ	COL6A3	2511	P12111
LPSPTSETVLTVAAF	ECSCR	111	Q19T08
LFFFVNNTIPPTSAT	GABARAPL3	76	Q9BY60
PLPVFSTFVLTGSSA	DENND4C	251	Q5VZ89
PQNISLPSAASFTFS	ADGRG1	146	Q9Y653
PSAFQSLRTPSASAL	ANK3	1786	Q12955
TTPALVLAPAQFLSS	COL27A1	586	Q8IZC6
SELSSPPRQFAAVSI	EPHA3	416	P29320
LPSGSLTPAFFTAQT	ELK3	321	P41970
IPTVFSFNPANTTTS	MS4A18	291	Q3C1V0
NVLNTPSSAAFPTAS	MBD5	531	Q9P267
QPAFATVTPSSSSVL	INO80D	931	Q53TQ3
SPSFIVSPLNSSSAL	GNL3	306	Q9BVP2
NTSSAGTLTQVPFFP	CCDC158	41	Q5M9N0
QETSVAPFALPTVSL	HDAC7	236	Q8WUI4
ASVNLFPTISVAPSA	FHOD1	416	Q9Y613
TQGLAVSTISSFFPP	FCGR3A	191	P08637
ASSSLPAVVVETFPA	BIN1	486	O00499
NSSATCPFLSETIIP	C5orf34	76	Q96MH7
APPTSIALQVFFTAR	DLEC1	1701	Q9Y238
SLTQAAFTPIPVDTS	RYR2	856	Q92736
VLATPSLSASFNAPL	DYSF	91	O75923
TTGFPSLITIFSAPN	PPP3CA	296	Q08209
PVAFSVVPTAAAAVS	C4A	896	P0C0L4
PSFSSITSANSVDLP	MED1	286	Q15648
ASPSNSSTVPVSEFL	OR56A1	6	Q8NGH5
AASATPFALPITSTS	NUP58	116	Q9BVL2
LASVTFFATSDSQPP	SLC8B1	401	Q6J4K2
FPSISSLTESRFSNP	RUNX2	376	Q13950
QLLTTASSSFPPASE	RSBN1	751	Q5VWQ0
LNASFLASPTELPSA	SLC4A11	536	Q8NBS3
LASVESVPFSFDPNT	TRIM35	296	Q9UPQ4
DLVPSESNAFLPSSV	SPAG5	231	Q96R06
TFSSPNFATIPQDTV	SPON2	196	Q9BUD6
PLPATSSFSFASLLN	SLC22A17	286	Q8WUG5
AANVLFPSAASFPLT	NKX1-2	271	Q9UD57
STSAPSLIFILPSIF	SLC38A5	406	Q8WUX1
TFIPLNSDASATLPL	POU1F1	11	P28069
FSQPARSFSQLSPLV	PRDM8	501	Q9NQV8
FITPSTTVPSVFELN	GPAM	556	Q9HCL2
SQTPTPSSTFFQAEL	SENP1	326	Q9P0U3
VLFTSTCAFPSSTLP	SIPA1L3	1571	O60292
IISSPLSTFFSAAPG	TENM2	1031	Q9NT68
PPSSFSRFSQAVILS	OPRPN	71	Q99935
TAVAQAPPAVASSSL	SERTAD1	31	Q9UHV2
APPAVASSSLFDLSV	SERTAD1	36	Q9UHV2
LLALSTFSTSPQDFP	EXTL1	391	Q92935
LETPSQNIFFSPVSV	SERPINA9	61	Q86WD7
NYLAPVSASVSPSAV	SRF	301	P11831
FNFPSQAITSPRATV	ST18	476	O60284
AAATIPANSSDAPFI	CHST8	121	Q9H2A9
PFQISLPSSELASSS	INPP5J	836	Q15735
VTTASSAQTFPISAP	ZNF384	131	Q8TF68
DPFSSPLLSIIQTFS	TRPA1	896	O75762
ENPLLSSQFTFTPTE	UNC80	3231	Q8N2C7
SAPFTQPLSSNEIFR	POLR3C	281	Q9BUI4
QSEAPPSLVSFAVSS	SYNPO2	316	Q9UMS6
VTSSLAPPVTAVFVL	SLC5A10	446	A0PJK1
PPFSVTTANGTISFT	SLC26A11	286	Q86WA9
GNIFFSPVSISTTLA	SERPINA11	71	Q86U17
ASAPALAPQVATSYT	SPATC1	336	Q76KD6
PFASLTATSQPIAAA	UBE4B	221	O95155
SFTQVTLPSFSPSAA	SREBF2	91	Q12772
NPFSAAPAATTVVQT	SAP130	636	Q9H0E3
PGAASQFIAATPTSL	TTBK2	641	Q6IQ55
VPLQTSDSFLRFPSS	TCTN1	211	Q2MV58
PVFTISTNFPIIAVT	TMEM104	361	Q8NE00
NVASLAFPFTTPVLV	ZNF620	46	Q6ZNG0
TVNTTVFNASAPLAP	SLC4A5	686	Q9BY07
PFTVLVPSVSSFSSR	STAB1	396	Q9NY15
IVSSPLSTFFRSSPE	TENM3	966	Q9P273
LESFPAVLPSVSVSQ	USF3	841	Q68DE3
PLVPLRTFQSSLFSS	nan	31	A1L4Q6
AAPSFQFINPTTITS	WDR59	441	Q6PJI9
VNLPPSSTSTIADTF	ZMYM5	486	Q9UJ78
SSFNPATFQSLLIPR	SH2D3C	551	Q8N5H7
PSVFFTRVSTLPATS	TRAPPC9	886	Q96Q05
LPQFPSSLATVSASV	WNK2	1066	Q9Y3S1
DSFTVLSENPPSFTI	RWDD1	21	Q9H446
VPSNFQSLVASSPAA	SETBP1	761	Q9Y6X0
ILTTATPAFSPFTLV	VWA7	846	Q9Y334
DDFPLTLASAVPSQT	TRBV6-4	91	A0A1B0GX49
FIPRSAQPITFTTAS	TOB2	166	Q14106
PSTTAAPLLSLASAF	WNK4	916	Q96J92
ILDSFAAAPVPTTTL	SON	241	P18583
ISRFFAQSQSLTPSP	TNRC6A	1856	Q8NDV7
PSFPSLSAANLVIAI	TSPAN9	46	O75954
SLNPAAFVPITSSTD	TTLL5	1261	Q6EMB2
VAIASIQSAATFPDP	USF1	31	P22415
APTQALPEFTSIFSS	KLF5	181	Q13887
PIFARSQASALTATP	LRFN2	216	Q9ULH4
FFPSTNTTAATVAPS	MYPN	726	Q86TC9