Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Pyrin domain binding	NLRP7 NLRP2	4.51e-06	3	25	2	GO:0032090
GeneOntologyMolecularFunction	aspartic-type endopeptidase inhibitor activity	NLRP7 NLRP2	5.39e-05	9	25	2	GO:0019828
GeneOntologyMolecularFunction	interleukin-1 binding	NLRP7 NLRP2	9.86e-05	12	25	2	GO:0019966
GeneOntologyMolecularFunction	caspase binding	NLRP7 NLRP2	1.79e-04	16	25	2	GO:0089720
GeneOntologyMolecularFunction	protease binding	NLRP7 FLOT1 NLRP2	1.45e-03	181	25	3	GO:0002020
Domain	-	KDM5B ARID3A	1.79e-04	15	25	2	1.10.150.60
Domain	ARID	KDM5B ARID3A	1.79e-04	15	25	2	PF01388
Domain	BRIGHT	KDM5B ARID3A	1.79e-04	15	25	2	SM00501
Domain	ARID_dom	KDM5B ARID3A	1.79e-04	15	25	2	IPR001606
Domain	ARID	KDM5B ARID3A	1.79e-04	15	25	2	PS51011
Domain	DAPIN	NLRP7 NLRP2	3.91e-04	22	25	2	PS50824
Domain	DAPIN	NLRP7 NLRP2	3.91e-04	22	25	2	IPR004020
Domain	PYRIN	NLRP7 NLRP2	3.91e-04	22	25	2	SM01289
Domain	PYRIN	NLRP7 NLRP2	3.91e-04	22	25	2	PF02758
Domain	NACHT	NLRP7 NLRP2	4.28e-04	23	25	2	PS50837
Domain	NACHT_NTPase	NLRP7 NLRP2	4.28e-04	23	25	2	IPR007111
Domain	-	NLRP7 NLRP2	6.83e-03	93	25	2	1.10.533.10
Domain	DEATH-like_dom	NLRP7 NLRP2	7.71e-03	99	25	2	IPR011029
Pubmed	Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress.	NLRP7 NLRP2	4.96e-07	2	25	2	30454891
Pubmed	Nlrp2, a maternal effect gene required for early embryonic development in the mouse.	NLRP7 NLRP2	4.96e-07	2	25	2	22295082
Pubmed	A genetic association study of NLRP2 and NLRP7 genes in idiopathic recurrent miscarriage.	NLRP7 NLRP2	4.96e-07	2	25	2	23360675
Pubmed	NLRP2 controls age-associated maternal fertility.	NLRP7 NLRP2	4.96e-07	2	25	2	27881734
Pubmed	NLRP2 is highly expressed in a mouse model of ischemic stroke.	NLRP7 NLRP2	4.96e-07	2	25	2	27693696
Pubmed	NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity.	NLRP7 NLRP2	4.96e-07	2	25	2	31162334
Pubmed	Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect.	NLRP7 NLRP2	4.96e-07	2	25	2	33090377
Pubmed	Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.	NLRP7 NLRP2	1.49e-06	3	25	2	21976665
Pubmed	Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.	NLRP7 NLRP2	1.49e-06	3	25	2	37499769
Pubmed	HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.	NLRP7 NLRP2	1.49e-06	3	25	2	39052836
Pubmed	Mosaic moles and non-familial biparental moles are not caused by mutations in NLRP7, NLRP2 or C6orf221.	NLRP7 NLRP2	1.49e-06	3	25	2	22909446
Pubmed	Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B.	NLRP7 NLRP2	1.49e-06	3	25	2	36976514
Pubmed	No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.	NLRP7 NLRP2	1.49e-06	3	25	2	25376457
Pubmed	Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke.	NLRP7 NLRP2	1.49e-06	3	25	2	30172704
Pubmed	NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse.	NLRP7 NLRP2	1.49e-06	3	25	2	28630100
Pubmed	Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma.	NLRP7 NLRP2	1.49e-06	3	25	2	37273114
Pubmed	Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring.	NLRP7 NLRP2	1.49e-06	3	25	2	29574422
Pubmed	Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses.	NLRP7 NLRP2	2.97e-06	4	25	2	22750073
Pubmed	The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response.	NLRP7 NLRP2	2.97e-06	4	25	2	23964092
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DHX16 HIP1R TUBGCP6 VPS52 MAGED4 GCAT	3.65e-06	606	25	6	36538041
Pubmed	Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.	NLRP7 NLRP2	4.95e-06	5	25	2	17046979
Pubmed	Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.	NLRP7 NLRP2	7.43e-06	6	25	2	12387869
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUBGCP6 CUL9 VPS52 ATXN7L2 TRRAP GCAT EVI5L	9.95e-06	1116	25	7	31753913
Pubmed	PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.	NLRP7 NLRP2	1.04e-05	7	25	2	15817483
Pubmed	Structural, expression, and evolutionary analysis of mouse CIAS1.	NLRP7 NLRP2	1.04e-05	7	25	2	15302403
Pubmed	Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.	NLRP7 NLRP2	1.39e-05	8	25	2	28317850
Pubmed	PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.	NLRP7 NLRP2	1.39e-05	8	25	2	12019269
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP7 NLRP2	4.49e-05	14	25	2	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP7 NLRP2	4.49e-05	14	25	2	12563287
Pubmed	Human transcription factor protein interaction networks.	CSTF2 CUL9 ATXN7L2 ARID3A FLOT1 TRRAP ZFP30	4.88e-05	1429	25	7	35140242
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX16 CSTF2 KDM5B ROGDI FLOT1 TRRAP	9.53e-05	1082	25	6	38697112
Pubmed	Host determinants of HIV-1 control in African Americans.	TUBGCP6 EVI5L	1.60e-04	26	25	2	20205591
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	NLRP7 NLRP2	1.85e-04	28	25	2	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	NLRP7 NLRP2	2.13e-04	30	25	2	38786026
Pubmed	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	DHX16 VPS52 FLOT1	2.65e-04	175	25	3	19851445
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HIP1R TUBGCP6 NLRP2	3.03e-04	183	25	3	31932471
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DHX16 CSTF2 ARID3A TRRAP	4.39e-04	506	25	4	30890647
Pubmed	ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.	ATXN7L2 TRRAP	4.61e-04	44	25	2	37682711
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	DHX16 CUL9 VPS52 FLOT1	1.50e-04	503	25	4	chr6p21
Cytoband	6p21.3	DHX16 VPS52 FLOT1	3.36e-04	250	25	3	6p21.3
Cytoband	19q13.42	NLRP7 NLRP2	2.12e-03	125	25	2	19q13.42
GeneFamily	AT-rich interaction domain containing	KDM5B ARID3A	5.81e-05	15	14	2	418
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP7 NLRP2	1.65e-04	25	14	2	994
GeneFamily	NLR family	NLRP7 NLRP2	1.65e-04	25	14	2	666
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HIP1R UNC13C ZFP30 EVI5L	3.27e-06	185	25	4	636505a3d96f75d951ab42bcf8af6ae07abc732d
Disease	alcohol use disorder (implicated_via_orthology)	KDM5B UNC13C	1.18e-02	195	25	2	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERAMRQFAMDAAATA	AMOTL2	576	Q9Y2J4
EEVMAVRLREADSMA	EVI5L	641	Q96CN4
VRLREADSMAAVAEM	EVI5L	646	Q96CN4
ADSMAAVAEMRQRIA	EVI5L	651	Q96CN4
VDMARERFEAVMAVL	ADCK5	456	Q3MIX3
VAAMSVAARVAREMG	DHX16	456	O60231
DARGLEARAMEARAM	CSTF2	426	P33240
MAVRERAAAAMAALE	ATXN7L2	1	Q5T6C5
VDMAEEHARAQMRAQ	MAGED4	621	Q96JG8
LQEMRDAAVRMAAEA	LMAN1L	396	Q9HAT1
IMQAEAEAASVRMRG	FLOT1	306	O75955
ALSDRQMSERMALDA	TUBGCP6	686	Q96RT7
AMATLGEARLREMEA	KDM5B	1141	Q9UGL1
MATALMAVVLRAAAV	NAGS	1	Q8N159
DQAMRAFELMRSNAA	NLRP2	376	Q9NX02
VMLGDARLASRMADD	GCAT	351	O75600
SAAIEDAVRRIEDMM	HIP1R	791	O75146
AMGEMEADVQALVRR	CUL9	111	Q8IWT3
MATVMAATAAERAVL	ROGDI	1	Q9GZN7
VRVMDAVSFAAAMTA	SLC18B1	136	Q6NT16
DQAMRAFELMRSNAA	NLRP7	341	Q8WX94
RAQMAALAAMRAAAA	ARID3A	56	Q99856
MAAAATMAAAARELV	VPS52	1	Q8N1B4
MARDLVMFRDVAVDF	ZFP30	1	Q9Y2G7
AAMDAEIVLRSLMDF	UNC13C	1881	Q8NB66
EFRADARAVISLMEM	UBAC1	286	Q9BSL1
AHAMEARAIVRQAMA	TRRAP	1911	Q9Y4A5