Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	microtubule organizing center	MAPRE3 EYS CCDC28B DTX4 HYLS1 CCDC187 SMO TRAPPC14 BBS9 RASSF7 FAM110B PDZD2	1.64e-04	919	79	12	GO:0005815
HumanPheno	Preaxial foot polydactyly	GLI3 HYLS1 SMO FGFR3	2.41e-05	30	30	4	HP:0001841
HumanPheno	Abnormal hair pattern	KLF13 CCDC28B GLI3 APC2 NPAP1 TRIM8 PEX6 SMO SPOP FGFR3 PHF8 IDUA BBS9	4.82e-05	676	30	13	HP:0010720
HumanPheno	Puberty and gonadal disorders	DNHD1 COL7A1 EYS ERCC1 CCDC28B GLI3 NPAP1 TRIM8 PEX6 TLE6 SMO FGFR3 FIGLA DLL1 BBS9	5.02e-05	900	30	15	HP:0008373
HumanPheno	Death in neonatal period or infancy	KIF20A ORC1 ERCC1 GLI3 PEX6 HYLS1 SMO FGFR3 IDUA	5.57e-05	317	30	9	HP:0003827
HumanPheno	Cleft upper lip	GLI3 ARHGAP29 HYLS1 SMO SPOP PHF8 DLL1	6.95e-05	183	30	7	HP:0000204
HumanPheno	Abnormal male external genitalia morphology	DNHD1 ORC1 COL7A1 EYS ERCC1 CCDC28B GLI3 APC2 NPAP1 TRIM8 PEX6 HYLS1 SMO FGFR3 PHF8 IDUA DLL1 BBS9	8.74e-05	1329	30	18	HP:0000032
HumanPheno	Abnormal finger phalanx morphology	ORC1 ERCC1 CCDC28B GLI3 APC2 TRIM8 PEX6 HYLS1 SMO FGFR3 PHF8 IDUA BBS9	1.23e-04	738	30	13	HP:0005918
HumanPheno	Abnormal hallux phalanx morphology	GLI3 HYLS1 SMO FGFR3	1.34e-04	46	30	4	HP:0010057
HumanPheno	Abnormal external genitalia	DNHD1 ORC1 COL7A1 EYS ERCC1 CCDC28B GLI3 APC2 NPAP1 TRIM8 PEX6 HYLS1 SMO FGFR3 PHF8 IDUA DLL1 BBS9	1.37e-04	1372	30	18	HP:0000811
HumanPheno	External genital hypoplasia	DNHD1 ORC1 CCDC28B GLI3 NPAP1 TRIM8 PEX6 SMO PHF8 DLL1 BBS9	1.52e-04	544	30	11	HP:0003241
HumanPheno	Duplication involving bones of the feet	CCDC28B GLI3 HYLS1 SMO FGFR3 BBS9	1.75e-04	147	30	6	HP:0009136
HumanPheno	Foot polydactyly	CCDC28B GLI3 HYLS1 SMO FGFR3 BBS9	1.75e-04	147	30	6	HP:0001829
HumanPheno	Postaxial hand polydactyly	CCDC28B GLI3 HYLS1 SMO BBS9	2.00e-04	95	30	5	HP:0001162
HumanPheno	Heterotopias/abnormal migration	ERCC1 APC2 TRIM8 PEX6 HYLS1 SMO SPOP FGFR3 TRAPPC14 DLL1	2.53e-04	477	30	10	HP:0007317
HumanPheno	Abnormality of neuronal migration	ERCC1 APC2 TRIM8 PEX6 HYLS1 SMO SPOP FGFR3 TRAPPC14 DLL1	2.53e-04	477	30	10	HP:0002269
HumanPheno	Abnormality of the male genitalia	DNHD1 ORC1 COL7A1 EYS ERCC1 CCDC28B GLI3 APC2 NPAP1 TRIM8 PEX6 HYLS1 SMO FGFR3 PHF8 IDUA DLL1 BBS9	2.61e-04	1437	30	18	HP:0010461
HumanPheno	Abnormal cortical gyration	ERCC1 APC2 TRIM8 PEX6 HYLS1 SMO SPOP TRAPPC14 DLL1	2.66e-04	388	30	9	HP:0002536
HumanPheno	Flexion contracture of finger	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.79e-04	240	30	7	HP:0005651
HumanPheno	Camptodactyly (hands)	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.79e-04	240	30	7	HP:0010563
HumanPheno	Joint contractures involving the joints of the feet	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.79e-04	240	30	7	HP:0100492
HumanPheno	Camptodactyly of finger	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.79e-04	240	30	7	HP:0100490
HumanPheno	Interphalangeal joint contracture of finger	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.79e-04	240	30	7	HP:0001220
HumanPheno	Cleft lip	GLI3 ARHGAP29 HYLS1 SMO SPOP PHF8 DLL1	3.79e-04	240	30	7	HP:0410030
HumanPheno	Camptodactyly of toe	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.79e-04	240	30	7	HP:0001836
HumanPheno	Flexion contracture of toe	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.79e-04	240	30	7	HP:0005830
HumanPheno	Toe joint contracture	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	3.88e-04	241	30	7	HP:0034675
HumanPheno	Abnormal hand morphology	ORC1 COL7A1 KLF13 CCDC28B GLI3 APC2 NPAP1 TRIM8 PEX6 HYLS1 SMO SPOP FGFR3 PHF8 BBS9	4.43e-04	1082	30	15	HP:0005922
HumanPheno	Death in infancy	KIF20A ORC1 ERCC1 PEX6 SMO FGFR3 IDUA	4.62e-04	248	30	7	HP:0001522
HumanPheno	Onset in infancy	KIF20A ORC1 ERCC1 PEX6 SMO FGFR3 IDUA	4.62e-04	248	30	7	HP:0003576
HumanPheno	Hypoplastic male external genitalia	DNHD1 ORC1 CCDC28B GLI3 NPAP1 TRIM8 SMO PHF8 DLL1 BBS9	4.66e-04	514	30	10	HP:0000050
HumanPheno	Abnormality of the peripheral nervous system	CCDC28B LIN28B GLI3 APC2 SCN10A PEX6 HYLS1 SMO IDUA DLL1 BBS9	4.68e-04	617	30	11	HP:0410008
HumanPheno	Abnormal uvea morphology	CACNA1F EYS ERCC1 CCDC28B LIN28B POLH APC2 NPAP1 PEX6 HYLS1 SMO FGFR3 DLL1 BBS9	4.89e-04	965	30	14	HP:0000553
HumanPheno	Foot joint contracture	ORC1 COL7A1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	5.13e-04	334	30	8	HP:0008366
HumanPheno	Abnormality of the vasculature of the eye	CACNA1F COL7A1 EYS ERCC1 CCDC28B POLH PEX6 FGFR3 BBS9	5.17e-04	424	30	9	HP:0008047
HumanPheno	Hypertrichosis	KLF13 CCDC28B GLI3 TRIM8 SMO SPOP PHF8 IDUA BBS9	5.26e-04	425	30	9	HP:0000998
HumanPheno	Hand polydactyly	CCDC28B GLI3 HYLS1 SMO FGFR3 PHF8 BBS9	5.34e-04	254	30	7	HP:0001161
HumanPheno	Duplication of phalanx of hand	CCDC28B GLI3 HYLS1 SMO FGFR3 PHF8 BBS9	5.74e-04	257	30	7	HP:0009997
HumanPheno	Flexion contracture of finger	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	5.74e-04	257	30	7	HP:0012785
HumanPheno	Duplication of hand bones	CCDC28B GLI3 HYLS1 SMO FGFR3 PHF8 BBS9	5.87e-04	258	30	7	HP:0004275
HumanPheno	Duplication of bones involving the upper extremities	CCDC28B GLI3 HYLS1 SMO FGFR3 PHF8 BBS9	5.87e-04	258	30	7	HP:0009142
HumanPheno	Finger joint contracture	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	6.01e-04	259	30	7	HP:0034681
HumanPheno	Abnormal finger morphology	ORC1 COL7A1 ERCC1 KLF13 CCDC28B GLI3 APC2 NPAP1 TRIM8 PEX6 HYLS1 SMO SPOP FGFR3 PHF8 IDUA BBS9	6.10e-04	1385	30	17	HP:0001167
HumanPheno	Abnormal phalangeal joint morphology of the hand	ORC1 ERCC1 GLI3 APC2 PEX6 FGFR3 IDUA	6.44e-04	262	30	7	HP:0006261
HumanPheno	Abnormality of the autonomic nervous system	CCDC28B LIN28B APC2 SCN10A HYLS1 SMO DLL1 BBS9	6.50e-04	346	30	8	HP:0002270
HumanPheno	Abnormality of the palpebral fissures	ORC1 ERCC1 KLF13 GLI3 APC2 NPAP1 PEX6 SMO SPOP FGFR3 PHF8 TRAPPC14 BBS9	7.40e-04	880	30	13	HP:0008050
HumanPheno	Postaxial foot polydactyly	CCDC28B GLI3 SMO BBS9	7.62e-04	72	30	4	HP:0001830
HumanPheno	Abnormal vagina morphology	COL7A1 CCDC28B GLI3 HYLS1 BBS9	7.97e-04	128	30	5	HP:0000142
HumanPheno	Abnormal toe phalanx morphology	GLI3 TRIM8 HYLS1 SMO FGFR3	8.55e-04	130	30	5	HP:0010161
HumanPheno	Abnormal toe morphology	ORC1 ERCC1 CCDC28B GLI3 APC2 TRIM8 PEX6 HYLS1 SMO FGFR3 PHF8 IDUA BBS9	8.55e-04	893	30	13	HP:0001780
HumanPheno	Abnormal hair morphology	ORC1 COL7A1 KLF13 CCDC28B GLI3 POLH APC2 NPAP1 TRIM8 PEX6 HYLS1 SMO SPOP FGFR3 PHF8 IDUA BBS9	8.66e-04	1424	30	17	HP:0001595
HumanPheno	Osteochondroma	GLI3 FGFR3	9.19e-04	8	30	2	HP:0030431
HumanPheno	Mortality/Aging	KIF20A ORC1 ERCC1 GLI3 SCN10A PEX6 HYLS1 SMO FGFR3 IDUA	9.65e-04	563	30	10	HP:0040006
HumanPheno	Age of death	KIF20A ORC1 ERCC1 GLI3 SCN10A PEX6 HYLS1 SMO FGFR3 IDUA	9.65e-04	563	30	10	HP:0011420
HumanPheno	Large hands	APC2 PEX6 PHF8	9.75e-04	34	30	3	HP:0001176
Pubmed	Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.	DHX15 NCOA3 GLI3 SPOP	2.23e-06	40	80	4	28805822
Pubmed	IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.	GLI3 SMO BBS9	3.30e-06	13	80	3	25446516
Pubmed	Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.	GLI3 SMO SPOP	3.30e-06	13	80	3	19684112
Pubmed	Cross-talk between the NR3B and NR4A families of orphan nuclear receptors.	NR4A1 GRIN3B	5.23e-06	2	80	2	17543277
Pubmed	A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment.	GLI3 SCRIB	5.23e-06	2	80	2	12112872
Pubmed	Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover.	NCOA3 SPOP	5.23e-06	2	80	2	23559371
Pubmed	Overexpression of KLF13 and FGFR3 in oral cancer cells.	KLF13 FGFR3	5.23e-06	2	80	2	20539070
Pubmed	The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.	GLI3 SMO FGFR3	6.42e-06	16	80	3	23026747
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ORC1 RIN3 ZNF276 ARAP3 PTPRS IL17RE PEX6 IDUA DLL1 D2HGDH RASSF7 C2CD2L	8.21e-06	1105	80	12	35748872
Pubmed	SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.	NCOA3 GLI3 SPOP	9.33e-06	18	80	3	29996942
Pubmed	The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice.	GLI3 SMO FGFR3	1.51e-05	21	80	3	20081193
Pubmed	Temporomandibular joint formation requires two distinct hedgehog-dependent steps.	GLI3 SMO FGFR3	1.51e-05	21	80	3	19815519
Pubmed	Mechanism of shortened bones in mucopolysaccharidosis VII.	FGFR3 IDUA	1.57e-05	3	80	2	19375967
Pubmed	Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.	GLI3 SPOP	1.57e-05	3	80	2	19955409
Pubmed	Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels.	GLI3 SMO	1.57e-05	3	80	2	24548465
Pubmed	EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue.	MAPRE3 APC2	1.57e-05	3	80	2	10644998
Pubmed	Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.	GLI3 SMO	1.57e-05	3	80	2	16229832
Pubmed	GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer.	GLI3 SPOP	1.57e-05	3	80	2	34610962
Pubmed	Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis.	SORBS2 GLI3 FGFR3 DLL1	2.00e-05	69	80	4	18725516
Pubmed	Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.	GLI3 SPOP	3.13e-05	4	80	2	26475525
Pubmed	SPOP-PTEN-SUFU axis promotes progression of clear cell renal cell carcinoma via activating SHH and WNT pathway.	GLI3 SPOP	3.13e-05	4	80	2	34021128
Pubmed	Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.	GLI3 SPOP	3.13e-05	4	80	2	27220849
Pubmed	The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.	GLI3 SMO	3.13e-05	4	80	2	24952464
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ZNF276 KLF13 LIN28B GLI3 FIGLA NR4A1 E2F8 HSF5	3.68e-05	544	80	8	28473536
Pubmed	Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons.	GLI3 SMO FGFR3	5.03e-05	31	80	3	22889265
Pubmed	Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.	GLI3 SMO	5.20e-05	5	80	2	15042696
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	KIF20A NCOA3 NFATC2IP GLI3 PRAMEF20 SMO FGFR3	5.63e-05	424	80	7	21731673
Pubmed	PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling.	GLI3 SMO DLL1	6.08e-05	33	80	3	36218069
Pubmed	GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis.	GLI3 SMO SPOP	7.27e-05	35	80	3	31167144
Pubmed	Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium.	GLI3 SMO	7.79e-05	6	80	2	19432668
Pubmed	Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions.	GLI3 SMO	7.79e-05	6	80	2	24174682
Pubmed	Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.	GLI3 SMO SPOP	7.92e-05	36	80	3	31604927
Pubmed	Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain.	GLI3 SMO	1.09e-04	7	80	2	20943901
Pubmed	ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.	NCOA3 SPOP	1.09e-04	7	80	2	34144977
Pubmed	Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal.	GLI3 SMO	1.09e-04	7	80	2	23201751
Pubmed	The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.	NCOA3 NR4A1	1.45e-04	8	80	2	12082103
Pubmed	Hedgehog-regulated localization of Vax2 controls eye development.	GLI3 SMO	1.45e-04	8	80	2	17043310
Pubmed	Expression of hedgehog signalling components in adult mouse testis.	GLI3 SMO	1.45e-04	8	80	2	16958114
Pubmed	An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.	SCRIB DLL1	1.45e-04	8	80	2	21559415
Pubmed	A subcortical maternal complex essential for preimplantation mouse embryogenesis.	TLE6 FIGLA	1.45e-04	8	80	2	18804437
Pubmed	A catalogue of gene expression in the developing kidney.	KIF20A SMO	1.86e-04	9	80	2	14531791
Pubmed	Xeroderma Pigmentosum	ERCC1 POLH	1.86e-04	9	80	2	20301571
Pubmed	The Shh signalling pathway in early tooth development.	GLI3 SMO	2.32e-04	10	80	2	10512189
Pubmed	The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.	GLI3 SMO	2.32e-04	10	80	2	19549984
Pubmed	A role for primary cilia in aortic valve development and disease.	GLI3 SMO	2.32e-04	10	80	2	28556366
Pubmed	Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.	GLI3 FGFR3	2.32e-04	10	80	2	16284117
Pubmed	Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.	NCOA3 SPOP	2.32e-04	10	80	2	21577200
Pubmed	A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb.	GLI3 SMO	2.32e-04	10	80	2	18832070
Pubmed	Tbx5 inhibits hedgehog signaling in determination of digit identity.	GLI3 SMO	2.32e-04	10	80	2	31373354
Pubmed	Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling.	GLI3 SMO	2.32e-04	10	80	2	18083924
Pubmed	Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation.	GLI3 SPOP	2.84e-04	11	80	2	36252002
Pubmed	Genetic networks controlling retinal injury.	CCL18 NR4A1	2.84e-04	11	80	2	16288200
Pubmed	Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins.	GLI3 SMO	2.84e-04	11	80	2	16364285
Pubmed	PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.	GLI3 SMO	2.84e-04	11	80	2	24697898
Pubmed	The SIL gene is required for mouse embryonic axial development and left-right specification.	GLI3 SMO	2.84e-04	11	80	2	10385121
Pubmed	Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.	GLI3 SMO	2.84e-04	11	80	2	15668330
Pubmed	GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.	GLI3 SMO	2.84e-04	11	80	2	16396903
Pubmed	Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.	GLI3 FGFR3	2.84e-04	11	80	2	19389374
Pubmed	The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.	GLI3 SMO	2.84e-04	11	80	2	22689656
Pubmed	The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants.	GLI3 SMO	2.84e-04	11	80	2	9655803
Pubmed	Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.	GLI3 SMO	3.40e-04	12	80	2	20050020
Pubmed	IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.	GLI3 SMO	3.40e-04	12	80	2	22595669
Pubmed	Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.	GLI3 SPOP	3.40e-04	12	80	2	28412462
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	GLI3 SMO	3.40e-04	12	80	2	10981962
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	GLI3 SMO	3.40e-04	12	80	2	18417110
Pubmed	SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.	GLI3 SPOP	3.40e-04	12	80	2	31911863
Pubmed	Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.	GLI3 FGFR3	3.40e-04	12	80	2	17660199
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	MAPRE3 C9orf43 RIN3 ARAP3 CHTF18 CYP46A1	3.73e-04	410	80	6	25814554
Pubmed	Expression patterns of Hedgehog signalling pathway members during mouse palate development.	GLI3 SMO	4.01e-04	13	80	2	16168717
Pubmed	T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.	GLI3 SMO	4.01e-04	13	80	2	25760946
Pubmed	A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.	GLI3 SMO	4.01e-04	13	80	2	25995356
Pubmed	Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex.	APC2 NR4A1	4.01e-04	13	80	2	35915179
Pubmed	A Combinatorial CRISPR-Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment.	FGFR3 GRIN3B	4.01e-04	13	80	2	34666996
Pubmed	The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.	GLI3 SMO	4.01e-04	13	80	2	19592253
Pubmed	Temporomandibular joint formation and condyle growth require Indian hedgehog signaling.	GLI3 SMO	4.01e-04	13	80	2	17191253
Pubmed	Gli2 influences proliferation in the developing lung through regulation of cyclin expression.	GLI3 SMO	4.01e-04	13	80	2	19574535
Pubmed	Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium.	GLI3 SMO	4.01e-04	13	80	2	22275805
Pubmed	Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.	GLI3 SPOP	4.67e-04	14	80	2	20463034
Pubmed	GLI3 repressor controls functional development of the mouse ureter.	GLI3 SMO	4.67e-04	14	80	2	21339645
Pubmed	Lrp4 modulates extracellular integration of cell signaling pathways in development.	GLI3 SMO	4.67e-04	14	80	2	19116665
Pubmed	BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period.	GLI3 SMO	4.67e-04	14	80	2	37300483
Pubmed	Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.	GLI3 SMO	4.67e-04	14	80	2	32151560
Pubmed	Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5.	FGFR3 IDUA	4.67e-04	14	80	2	7919654
Pubmed	Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling.	GLI3 SMO	4.67e-04	14	80	2	19666503
Pubmed	Complex interactions between genes controlling trafficking in primary cilia.	GLI3 SMO	4.67e-04	14	80	2	21552265
Pubmed	Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.	GLI3 SMO	4.67e-04	14	80	2	24076664
Pubmed	Cilia-dependent GLI processing in neural crest cells is required for tongue development.	GLI3 SMO	4.67e-04	14	80	2	28286175
Pubmed	Nucleosome-interacting proteins regulated by DNA and histone methylation.	ORC1 PHF8	5.38e-04	15	80	2	21029866
Pubmed	Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.	GLI3 SMO	5.38e-04	15	80	2	34486668
Pubmed	A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.	GLI3 SMO	5.38e-04	15	80	2	25458012
Pubmed	THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.	GLI3 SMO	5.38e-04	15	80	2	18327258
Pubmed	A role for smoothened during murine lens and cornea development.	GLI3 SMO	5.38e-04	15	80	2	25268479
Pubmed	LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.	GLI3 SMO	5.38e-04	15	80	2	22340494
Pubmed	Deletion of Lrp4 increases the incidence of microphthalmia.	GLI3 SMO FGFR3	5.50e-04	69	80	3	30352686
Pubmed	Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome.	GLI3 SMO	6.14e-04	16	80	2	15005800
Pubmed	The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling.	GLI3 SMO	6.14e-04	16	80	2	31964774
Pubmed	Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice.	GLI3 SMO	6.95e-04	17	80	2	22402963
Pubmed	An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression.	GLI3 AKIRIN2	6.95e-04	17	80	2	30116001
Pubmed	Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.	GLI3 SMO	6.95e-04	17	80	2	16571630
Pubmed	Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling.	GLI3 SMO	6.95e-04	17	80	2	24948802
Cytoband	19p13.3	EBI3 PTPRS APC2 TLE6 GRIN3B	6.16e-05	237	80	5	19p13.3
GeneFamily	AAA ATPases	ORC1 CHTF18 PEX6	3.98e-04	53	49	3	413
GeneFamily	Fibronectin type III domain containing	FNDC3B COL7A1 EBI3 PTPRS	9.18e-04	160	49	4	555
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIF20A ORC1 COL7A1 C9orf43 MTFR2 E2F8	8.04e-07	177	80	6	26c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIF20A ORC1 MTFR2 CYP46A1 E2F8 C2CD2L	8.31e-07	178	80	6	c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	KIF20A ORC1 MTFR2 CYP46A1 E2F8 C2CD2L	9.46e-07	182	80	6	b1e66ccd5f33b4801f1cafddf97f5fc0c6dba8d1
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ORC1 CHTF18 DLL1 BBS9 FAM110B	7.33e-06	149	80	5	4b44108c40376a6b73258df40d2424e68f991383
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MOK COL7A1 RHOV CCDC187 GRIN3B	8.08e-06	152	80	5	854c841c1fc6300b7e9be9c98cbf9b0ce2678690
ToppCell	Dividing_Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	KIF20A ORC1 MTFR2 E2F8 HSF5	1.24e-05	166	80	5	c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Unc5b_(Neuron.Gad1Gad2.Pvalb-Unc5b)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KIF20A COL7A1 GRIN3B HSF5	1.26e-05	79	80	4	cc17a013a4a57a99c404b10449ef61ce559631d1
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Unc5b_(Neuron.Gad1Gad2.Pvalb-Unc5b)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KIF20A COL7A1 GRIN3B HSF5	1.26e-05	79	80	4	19fb2bc964589ea40e7b9f0809c641331c93dacd
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	KIF20A ORC1 CYP46A1 E2F8 C2CD2L	1.35e-05	169	80	5	02fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ORC1 COL7A1 RHOV FGFR3 NR4A1	1.55e-05	174	80	5	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B ARAP3 EBI3 NR4A1 LRRC58	1.60e-05	175	80	5	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	KIF20A ORC1 C9orf43 MTFR2 E2F8	1.60e-05	175	80	5	74800a10f5ff25d5414fbccb0668f92ff077d1cc
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ORC1 COL7A1 C9orf43 MTFR2 E2F8	1.69e-05	177	80	5	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	Dividing_Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	KIF20A ORC1 CCL18 MTFR2 E2F8	2.14e-05	186	80	5	0067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIF20A ORC1 CCDC28B MTFR2 E2F8	2.43e-05	191	80	5	56b45259dfc38bd5ea43b0e3adf47e7e2c043a5d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KIF20A POLH HYLS1 MTFR2 E2F8	2.49e-05	192	80	5	0a54c79dcfdeb99e3b512d42b22359618cfd17e9
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	SCARF1 IL17RE DLL1 PDZD2 SORCS1	2.49e-05	192	80	5	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	Influenza_Severe-T/NK_proliferative\|World / Disease group and Cell class	KIF20A ORC1 CCDC28B MTFR2 E2F8	2.68e-05	195	80	5	6f079c2d7d08110a5e1822ea861b8037eb3f62c9
ToppCell	Caecum-B_cell-B_cell_cycling\|Caecum / Region, Cell class and subclass	KIF20A ORC1 EBI3 CHTF18 E2F8	2.89e-05	198	80	5	61294fe99a5641ad359796022c3d038470076b3c
ToppCell	Caecum-(2)_B_cell-(24)_B_cell_cycling\|Caecum / shred on region, Cell_type, and subtype	KIF20A ORC1 EBI3 CHTF18 E2F8	2.89e-05	198	80	5	568d47770cd20c6569ca84ea1eafde367642d68b
ToppCell	proximal-Epithelial-Proliferating_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KIF20A ORC1 COL7A1 MTFR2 E2F8	2.96e-05	199	80	5	521ff4ae3437c8ba477a0a42b9da195af976c3ff
ToppCell	severe_influenza-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	KIF20A ORC1 CCDC28B MTFR2 E2F8	2.96e-05	199	80	5	1541f655f7d12c650added3683d07e5417a68dfb
ToppCell	proximal-Epithelial-Proliferating_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KIF20A ORC1 COL7A1 MTFR2 E2F8	2.96e-05	199	80	5	e8549b2c4152cb23548351d9cee27c3805892cd8
ToppCell	proximal-3-Epithelial-Proliferating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KIF20A ORC1 COL7A1 MTFR2 E2F8	2.96e-05	199	80	5	2263bb73d9c5693b44d91d2548305efc1b6e4079
ToppCell	ILEUM-non-inflamed-(1)_T_cell-(1)_Highly_activated_T_cells\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	KIF20A ORC1 EBI3 MTFR2 E2F8	2.96e-05	199	80	5	f9bf94ab6b5b134f5b98a65340843b147941ab58
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIF20A ORC1 CCDC28B MTFR2 E2F8	3.03e-05	200	80	5	fcd16d36f67abf154428242b398b71473f281758
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIF20A ORC1 CCDC28B MTFR2 E2F8	3.03e-05	200	80	5	146f11b521b4b0c2a69f1ee86fb71011c7658914
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIF20A ORC1 CCDC28B MTFR2 E2F8	3.03e-05	200	80	5	562309f9ca4a73cea5ed1d85b516891545f3ae5f
ToppCell	MS-IIF-Lymphocyte-T/NK-T/NK_proliferative\|IIF / Disease, condition lineage and cell class	KIF20A ORC1 CCDC28B CCL18 MTFR2	3.03e-05	200	80	5	c7c1806a1054b2b034a26a18aac93fc3bec4dbc8
ToppCell	(3)_ILC\|World / shred on Cell_type and subtype	SCARF1 RIN3 NR4A1 DLL1 SORCS1	3.03e-05	200	80	5	03554b3f323785b1e0b48fa32de0d92065dd798e
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIF20A ORC1 CCDC28B MTFR2 E2F8	3.03e-05	200	80	5	b6a016132526e910f95bb40038bbb23f301ca023
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-T/NK_proliferative\|ICU-SEP / Disease, condition lineage and cell class	KIF20A ORC1 CCDC28B MTFR2 E2F8	3.03e-05	200	80	5	ae500c8b7c2162cadd31bf44ee9dc3271192cf17
ToppCell	(30)_ILC\|World / shred on Cell_type and subtype	SCARF1 RIN3 NR4A1 DLL1 SORCS1	3.33e-05	204	80	5	bd9fbd278c05e396463704d711b60d47699e3c09
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MOK EBI3 CCDC187 MTFR2	1.50e-04	149	80	4	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MOK EBI3 CCDC187 MTFR2	1.54e-04	150	80	4	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	droplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EBI3 NR4A1 LRRC58 LENG9	1.66e-04	153	80	4	6dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCell	droplet-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EBI3 NR4A1 LRRC58 LENG9	1.66e-04	153	80	4	f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	COL7A1 SMO FGFR3 DLL1	1.71e-04	154	80	4	38d346402417960044ae999e61f0092b46f2b591
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RHOV NPAP1 TLE6 NR4A1	1.75e-04	155	80	4	29c4e9947bb4f7e257ed5c3bcf21bd67f88d473f
ToppCell	PBMC-Severe-cDC_4\|Severe / Compartment, Disease Groups and Clusters	MOK KIF21B TRAPPC14 FAM110B	1.97e-04	160	80	4	4dac64e58d9366c399f3d830848ccb720d400be7
ToppCell	Basal_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	COL7A1 PTPRS RHOV SMO	1.97e-04	160	80	4	b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCell	PND01-03-samps-Myeloid-Macrophage-CD163+_Macrophage\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	KIF21B EBI3 IDUA MCRIP2	1.97e-04	160	80	4	4480a7d6bd48d06b4e5196faac868f31ab7ed3ad
ToppCell	390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EBI3 MTFR2 E2F8 PDZD2	2.12e-04	163	80	4	aa5ea367f787c1543afb7eb80a801432e1c44011
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PTPRS FGFR3 ACSS3 FAM110B	2.17e-04	164	80	4	519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell	mild_COVID-19_(asymptomatic)-Plasmablast\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	KIF20A ORC1 TLE6 E2F8	2.27e-04	166	80	4	0cc3b9681bc000a1b00d3b60f79f16eea1c2e2e1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A ORC1 ARAP3 E2F8	2.32e-04	167	80	4	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	mild_COVID-19_(asymptomatic)-Plasmablast\|World / disease group, cell group and cell class (v2)	KIF20A ORC1 TLE6 E2F8	2.32e-04	167	80	4	f26ae4de4804a3486502e3df37eabf3dfca688f5
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1F EBI3 CCDC28B GRIN3B	2.32e-04	167	80	4	8b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	CCDC28B POLH SLA2 C2CD2L	2.38e-04	168	80	4	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	SCARF1 DLL1 PDZD2 SORCS1	2.38e-04	168	80	4	d02eba7ece17edcdd47fd6b784c93910ce61090f
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	SCARF1 IL17RE DLL1 BBS9	2.38e-04	168	80	4	d8f485f8459532a2cb0bef899e6569142cf75685
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A POLH MTFR2 E2F8	2.43e-04	169	80	4	b253a4a50c06d36228fcd5d856c57202cbac158f
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCARF1 DNHD1 POLH APC2	2.43e-04	169	80	4	8a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCell	facs-Marrow-KLS-3m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B C9orf43 HSF5 C2CD2L	2.43e-04	169	80	4	b798b91567d2f49082e2d8a337169f241c8d2080
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	COL7A1 SMO FGFR3 DLL1	2.49e-04	170	80	4	aabe993c9f337b1caaeb0e64626a3920579c41b7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	SCARF1 DLL1 PDZD2 SORCS1	2.49e-04	170	80	4	97df5ffb328196c46568975d2d97722bcc753bf5
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ORC1 FGFR3 MTFR2 CYP46A1	2.49e-04	170	80	4	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	DTX4 POLH NR4A1 PHF8	2.49e-04	170	80	4	09bcbc7eb3b1d35cf03f01ce2f2fe37373382dd4
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	COL7A1 GLI3 FGFR3 DLL1	2.54e-04	171	80	4	3965ced4be6db14265a90673502fceee425837ca
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAPRE3 C9orf43 SCRIB PHF8	2.54e-04	171	80	4	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SORBS2 ARAP3 ARHGAP29 NR4A1	2.54e-04	171	80	4	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCARF1 SORBS2 MTFR2 PHF8	2.60e-04	172	80	4	c3a99828838af3b85c8c885d69cc8018f55ced50
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|367C / Donor, Lineage, Cell class and subclass (all cells)	BNIP5 EBI3 CCDC28B FIGLA	2.66e-04	173	80	4	94f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-ectodermal/neuroectodermal-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	ORC1 IL17RE PEX6 ACSS3	2.66e-04	173	80	4	7e4a2f5f92fbed16406bd097c0119278e4053245
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	COL7A1 EBI3 SMO FGFR3	2.72e-04	174	80	4	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOV CCDC187 SMO FGFR3	2.72e-04	174	80	4	a0ccda8fd6f55251cdeff24cf66e72e4a31d2104
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF20A CHTF18 MTFR2 E2F8	2.78e-04	175	80	4	a6913f992a1ea20b43e5adeca3ede3a6fda820ad
ToppCell	severe_influenza-Plasmablast\|World / disease group, cell group and cell class (v2)	KIF20A SORBS2 MTFR2 E2F8	2.78e-04	175	80	4	e6d6c44510d5dc4eb0bae820125e42366f7a4e74
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A HYLS1 MTFR2 E2F8	2.78e-04	175	80	4	876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRAP1 SORBS2 IDUA ACSS3	2.90e-04	177	80	4	164ffbbf798defa3728197deb1a14b661490e525
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KIF20A SCARF1 EBI3 NR4A1	2.90e-04	177	80	4	3a150dcaefa342d49968b42c7cdb1fbb633adcd0
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A CHTF18 E2F8 C2CD2L	2.90e-04	177	80	4	1d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KIF20A SCARF1 EBI3 NR4A1	2.90e-04	177	80	4	c9e5820ff0bc7ad1adcfb2651713fdfc58bced56
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIF20A ORC1 MTFR2 E2F8	2.96e-04	178	80	4	dbde3305e0c6a81593fe614e3f2e746b32cc16a7
ToppCell	Dividing_Macrophages-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	KIF20A ORC1 CHTF18 E2F8	2.96e-04	178	80	4	1893fadac2ec3d5de0a641e57b7b2f962012a9ba
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIF20A ORC1 MTFR2 E2F8	3.03e-04	179	80	4	ac987c9425a1b4106d1b8779a2c5461383eae2ae
ToppCell	10x5'v1-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	EYS IL17RE PDZD2 SORCS1	3.03e-04	179	80	4	bc95c3e7edc5fc6fc913b09f087d221df64c6f48
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A SORBS2 CHTF18 POLH	3.03e-04	179	80	4	df4d0b2fe47d2c7def729b3217cb01ced01495ff
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c14-MKI67-CCL5_h\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIF20A CHTF18 MTFR2 E2F8	3.09e-04	180	80	4	42f48e646fc6e72ad3cce72409ace3a0b64020a2
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A ARAP3 CHTF18 ARHGAP29	3.09e-04	180	80	4	b35a8c6169f4b548b912af005e92ae7c6596f376
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CHTF18 MTFR2 DLL1	3.16e-04	181	80	4	b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CHTF18 MTFR2 DLL1	3.16e-04	181	80	4	c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF20A KIF21B ORC1 MTFR2	3.16e-04	181	80	4	e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A POLH HYLS1 E2F8	3.22e-04	182	80	4	336cd05e46a741185ce3c59ee67a4b07fa6a5101
ToppCell	mild_COVID-19_(asymptomatic)-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	KIF20A ORC1 CCDC28B MTFR2	3.22e-04	182	80	4	9adf90bb2808f234d53b89ca0ae07380478204ad
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A MOK HYLS1 E2F8	3.22e-04	182	80	4	bc6a120dedc813c58baac1428c39851a07b71ba7
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A MOK HYLS1 E2F8	3.22e-04	182	80	4	0fc45214f0b0766f69be6eff69cc4bec574023aa
ToppCell	mild_COVID-19_(asymptomatic)-T/NK_proliferative\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	KIF20A ORC1 MTFR2 E2F8	3.29e-04	183	80	4	df8568751205313d149939ea2683097e3652a60b
ToppCell	IIF-Lymphocyte-T_NK-T_NK_proliferative\|IIF / Disease, Lineage and Cell Type	KIF20A ORC1 CCL18 MTFR2	3.36e-04	184	80	4	ab8b45ce40e8c5f66e5c23332a591b4f9cba4ce1
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	IL17RE DLL1 PDZD2 SORCS1	3.36e-04	184	80	4	479e60f76c191253e23699c9dd7ef7efc08c59ad
ToppCell	Bac-SEP-Lymphocyte-T_NK-T_NK_proliferative\|Bac-SEP / Disease, Lineage and Cell Type	ORC1 CCDC28B CHTF18 E2F8	3.36e-04	184	80	4	848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell	3'_v3-blood-Lymphocytic_T_CD4/8-lo\|blood / Manually curated celltypes from each tissue	KIF20A ORC1 MTFR2 E2F8	3.43e-04	185	80	4	df85ff34b796b403f2d0741771e9592e03657f6a
ToppCell	droplet-Heart-nan-24m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 ARAP3 ARHGAP29 BBS9	3.43e-04	185	80	4	11a44006950f6ccade86a85d5f06696d2036ffde
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KIF20A CHTF18 SLA2 MTFR2	3.50e-04	186	80	4	799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCell	facs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CHTF18 HYLS1 E2F8	3.50e-04	186	80	4	9feef5936985e936b3d88f9d1bb012abb6468570
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF13 FGFR3 NR4A1 RASSF7	3.50e-04	186	80	4	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	KIF20A CHTF18 SLA2 MTFR2	3.50e-04	186	80	4	5cadab3271fce9ab6da3d7ba9827b8a221cac166
ToppCell	facs-Skin-Telogen-3m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CHTF18 HYLS1 E2F8	3.50e-04	186	80	4	89f5b06bc56674af304912d481ac697c7c870904
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 SORBS2 ARAP3 DLL1	3.57e-04	187	80	4	3827fa80e558b642f3e0036f5ee1a8b69f437e30
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 SORBS2 ARAP3 DLL1	3.57e-04	187	80	4	1bf696eb03422ea507d3efe58dda1d442a65225d
Disease	Morphological abnormality of the central nervous system	APC2 DLL1	6.55e-06	2	76	2	C4021765
Disease	Polydactyly	GLI3 HYLS1 SMO FGFR3 BBS9	1.33e-05	117	76	5	C0152427
Disease	Xeroderma Pigmentosum	ERCC1 POLH	3.92e-05	4	76	2	C0043346
Disease	Xeroderma pigmentosum	ERCC1 POLH	2.33e-04	9	76	2	cv:C0043346
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI3 SMO	2.33e-04	9	76	2	DOID:0050338 (implicated_via_orthology)
Disease	craniosynostosis (is_implicated_in)	FGFR3 BBS9	4.25e-04	12	76	2	DOID:2340 (is_implicated_in)
Disease	Colorectal Carcinoma	COL7A1 ARAP3 PTPRS GLI3 APC2 NPAP1 FGFR3 FAM110B	4.48e-04	702	76	8	C0009402
Disease	Bardet-Biedl syndrome (is_implicated_in)	CCDC28B BBS9	5.84e-04	14	76	2	DOID:1935 (is_implicated_in)
Disease	hepatoblastoma (is_marker_for)	SMO SPOP	6.73e-04	15	76	2	DOID:687 (is_marker_for)
Disease	Non-Small Cell Lung Carcinoma	NCOA3 COL7A1 ERCC1 E2F8	7.17e-04	156	76	4	C0007131
Disease	digit length ratio	LIN28B GLI3	7.67e-04	16	76	2	EFO_0004841
Disease	Bardet-Biedl syndrome 1 (disorder)	CCDC28B BBS9	8.68e-04	17	76	2	C2936862
Disease	respiratory symptom change measurement, response to placebo	DHX15 BBS9	8.68e-04	17	76	2	EFO_0008344, EFO_0010068
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI3 SMO	8.68e-04	17	76	2	DOID:0060071 (biomarker_via_orthology)
Disease	Brachycephaly	FGFR3 BBS9	8.68e-04	17	76	2	C0221356
Disease	Bardet-Biedl syndrome	CCDC28B BBS9	9.75e-04	18	76	2	cv:C0752166
Disease	blood zinc measurement	SORBS2 RASSF7	1.60e-03	23	76	2	EFO_0007584
Disease	Malignant neoplasm of breast	FNDC3B NCOA3 COL7A1 ARAP3 POLH APC2 ARHGAP29 DLL1 SORCS1	1.74e-03	1074	76	9	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKRPLLAPLCNGLIN	COP1	111	Q8NHY2
PSQRPKQKVALLCGP	CHTF18	361	Q8WVB6
NPLGKEKDTLRPCPR	CCDC187	611	A0A096LP49
SCLKEQRLLGHPRPP	ARAP3	376	Q8WWN8
LLSPASPKRRRCAPL	AKIRIN2	16	Q53H80
SPQCPKPGVILLTKR	CCL18	51	P55774
VSGPLPCRLPLLKQI	DNHD1	1866	Q96M86
LLQQLKGAPPCPSRR	DNHD1	4506	Q96M86
LPGPKRGVACTQPRR	DHX15	181	O43143
AAGLPVCLTRPPKLV	DTX4	341	Q9Y2E6
LLGQRLKPRDPCCPS	ALG1L	161	Q6GMV1
SLPVKPRAALGCEPR	RASSF7	111	Q02833
ARLPRKASKPCSPAL	KIRREL3-AS3	171	Q8N7Y1
PQPASCLSRLLGKLP	NR4A1	546	P22736
LRRIQPPLGFGKLCP	CACNA1F	1486	O60840
CHPFLLGPPLVRKRI	TOR1AIP2	86	Q9H496
KLKCGPRPAVPQTRA	GLI3	1176	P10071
PSPCPLGLRLNVTVK	EYS	156	Q5T1H1
RLCAKGDIPPPLRAL	IL17RE	596	Q8NFR9
PCLGSERRPKGKTLQ	LIN28B	106	Q6ZN17
LALCPGLGPQKARRL	ERCC1	271	P07992
KRARLSVAAPCQPRP	LENG9	306	Q96B70
AILSKCPPGPVRLVI	PDZD2	796	O15018
CAVLKPRLQPGGALL	PEX6	446	Q13608
PGLTPCLPRRVLAIK	KIF21B	1616	O75037
RAKGNPISGPICAKR	JRKL	91	Q9Y4A0
TNGRVPVLRPLKCIP	MOK	376	Q9UQ07
PDGIPRVIQCKFRLP	BBS9	516	Q3SYG4
PSALPKGLAQSPLCR	LRRC58	106	Q96CX6
LRRVKTCNPPDAGPI	PTPRS	1571	Q13332
SLKPRTPRCAAPQIR	ORC1	461	Q13415
GLPDVNPMCQRPRLK	ARHGAP29	1231	Q52LW3
PRATPRKVAPPCLAQ	APC2	1811	O95996
CDLANGVIPRKLPFP	HYLS1	281	Q96M11
ARRPKRPSFLPLCVG	BNIP5	466	P0C671
VQLARSGPCKPVAPL	E2F8	461	A0AVK6
RRQLCPLTPGPGKAL	C2CD2L	381	O14523
LKPLDPVLCTLRPRG	CYP46A1	476	Q9Y6A2
LRLQKHRPPADPCRG	DLL1	571	O00548
PPRLECAAAGPQSLK	FNDC3B	961	Q53EP0
RPPKGLPDKSLINCT	C9orf43	96	Q8TAL5
RKGPPAALTLPRVQC	EBI3	21	Q14213
CARPEKPPGQVTRLR	IDUA	541	P35475
GRLGELLKCRQPAPP	MCRIP2	26	Q9BUT9
PCILRKNPPSARNGG	MAPRE3	181	Q9UPY8
AKPPVCPAAKRALGS	FAM110B	81	Q8TC76
GAAARKARTPCRLPP	KLF13	86	Q9Y2Y9
FLPQLARPGVPKVCI	COL7A1	131	Q02388
PLPQLAAVCRLKRLP	FIGLA	36	Q6QHK4
CRLRSPPKKGLGSPT	FGFR3	396	P22607
KPCLAQPAQAPGTLR	CCDC28B	11	Q9BUN5
LCPPKPRAVNVAFLG	D2HGDH	271	Q8N465
KLRLRIDPRLCPSPG	LRRC43	436	Q8N309
LPANPKNCLPHRRGI	RIN3	36	Q8TB24
PAFTLGCRLPLKPLD	ODF3L2	141	Q3SX64
QPKRALLPAPVNCGD	GRIN3B	311	O60391
AKLAAGLEVPCRPPN	HSF5	136	Q4G112
LLKEPCVLQRAGPLP	SLA2	186	Q9H6Q3
PRPCLRKEVFPLGGV	PRR14	376	Q9BWN1
RKRKLPCDTPGQGLT	NCOA3	16	Q9Y6Q9
FLRLPLGSLMKRPCP	PRAMEF20	61	Q5VT98
KSPLACTNKRPRPEG	POLH	686	Q9Y253
RDPAPPGLRELCIQK	SCRIB	1091	Q14160
LQDLRSCLSPKPPQG	NFATC2IP	226	Q8NCF5
VAPKRPCPLPRAAAA	NPAP1	66	Q9NZP6
LEPPQNGLCPKRRFS	SORBS2	536	O94875
PPRQALNRKKGSPGL	SCARF1	731	Q14162
ARCLGNIVVKLPLPP	ACSS3	496	Q9H6R3
PSLCPEGLKSRNFPR	ANHX	131	E9PGG2
SLSGKPKERCPPNLA	UHRF1BP1L	1081	A0JNW5
PRRRSAPPELGIKCV	RHOV	21	Q96L33
PPPVLRCRQFTVAGK	TRAPPC14	221	Q8WVR3
KKPFLRNLLPRTPTC	KIF20A	846	O95235
LSGPLRIPKPNRNIL	SCN10A	1771	Q9Y5Y9
LASAQCPFLGPPRKR	SPOP	356	O43791
VDPSPPRRSLGCKRK	SPDYE3	331	A6NKU9
PAGRRKPCAKVGAQP	ZNF276	161	Q8N554
ARACSGLLQPPKRPI	UBE2Q2L	16	H0YL09
IPRLPQLPRQKCLVA	SMO	701	Q99835
IGKMLPLEPCRRPNF	MTFR2	41	Q6P444
KPILCPRRTTAQLGP	TRAP1	31	Q12931
RKLPRAKPCSDPNRV	PHF8	676	Q9UPP1
KCPGKAPRGLRIVTA	SORCS1	791	Q8WY21
RRGPPLPAQKVCLRC	TRIM8	96	Q9BZR9
PDALPGQSKRLAVPC	TLE6	261	Q9H808