Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontetrahydrobiopterin binding

TH NOS1

1.63e-0441052GO:0034617
GeneOntologyMolecularFunctionAMPA glutamate receptor activity

GRIA3 GRIA4

1.63e-0441052GO:0004971
GeneOntologyBiologicalProcesscalcium-mediated signaling

ZMPSTE24 RCAN1 GRIA3 NCAM1 RYR2 ITPR1 PTPRC P2RX3 NOS1

8.14e-062661049GO:0019722
GeneOntologyCellularComponentterminal bouton

SLC4A8 GRIA3 GRIA4 TH P2RX3 TNN

9.44e-06961066GO:0043195
GeneOntologyCellularComponentpresynaptic membrane

GAD2 SLC4A8 PSEN1 ANO1 GRIA3 NCAM1 GRIA4 P2RX3 TENM3

1.18e-052771069GO:0042734
GeneOntologyCellularComponentdistal axon

SLC4A8 PSEN1 MAP2 GRIA3 NCAM1 GRIA4 ALS2 TH P2RX3 TNN NOS1

1.32e-0543510611GO:0150034
GeneOntologyCellularComponentneuronal cell body

GAD2 SLC4A8 PSEN1 MAP2 MYO10 NAIP GRIA3 NCAM1 GRIA4 ALS2 ITPR1 TH P2RX3 TNN TACR3

2.03e-0583510615GO:0043025
GeneOntologyCellularComponentcell body

GAD2 SLC4A8 PSEN1 MAP2 MYO10 NAIP GRIA3 NCAM1 GRIA4 ALS2 ITPR1 TH P2RX3 TNN TACR3

6.88e-0592910615GO:0044297
GeneOntologyCellularComponentCA3 pyramidal cell dendrite

MAP2 TNN

7.62e-0531062GO:0097442
GeneOntologyCellularComponentsmooth endoplasmic reticulum

PSEN1 RYR2 ITPR1 TH

8.65e-05461064GO:0005790
GeneOntologyCellularComponentaxon terminus

SLC4A8 GRIA3 GRIA4 TH P2RX3 TNN NOS1

9.82e-052101067GO:0043679
GeneOntologyCellularComponentsomatodendritic compartment

GAD2 SLC4A8 PSEN1 MAP2 MYO10 NAIP ANKS1B GRIA3 NCAM1 GRIA4 ALS2 ITPR1 TH P2RX3 TNN TACR3 NOS1

1.44e-04122810617GO:0036477
GeneOntologyCellularComponentpresynapse

GAD2 SLC4A8 PSEN1 ANKS1B ANO1 GRIA3 NCAM1 GRIA4 ITPR1 TH P2RX3 TENM3 TNN NOS1

1.54e-0488610614GO:0098793
GeneOntologyCellularComponentaxon

GAD2 SLC4A8 PSEN1 MAP2 GRIA3 NCAM1 GRIA4 ALS2 TH P2RX3 TENM3 TNN SBF2 NOS1

1.63e-0489110614GO:0030424
GeneOntologyCellularComponentmicrotubule associated complex

DNAH10 MAP2 MEFV DNAH14 KIF15 CFAP70

1.72e-041611066GO:0005875
GeneOntologyCellularComponentsynaptic membrane

GAD2 SLC4A8 PSEN1 ANO1 GRIA3 NCAM1 GRIA4 CSMD2 ITPR1 P2RX3 TENM3

1.83e-0458310611GO:0097060
GeneOntologyCellularComponentneuron projection terminus

SLC4A8 GRIA3 GRIA4 TH P2RX3 TNN NOS1

1.87e-042331067GO:0044306
GeneOntologyCellularComponentneuron to neuron synapse

SLC4A8 MAP2 ANKS1B GRIA3 GRIA4 ALS2 CSMD2 ITPR1 P2RX3 NOS1

3.28e-0452310610GO:0098984
GeneOntologyCellularComponentdendrite

SLC4A8 PSEN1 MAP2 ANKS1B GRIA3 GRIA4 ALS2 ITPR1 TH P2RX3 TNN TACR3 NOS1

4.01e-0485810613GO:0030425
GeneOntologyCellularComponentdendritic tree

SLC4A8 PSEN1 MAP2 ANKS1B GRIA3 GRIA4 ALS2 ITPR1 TH P2RX3 TNN TACR3 NOS1

4.10e-0486010613GO:0097447
GeneOntologyCellularComponenthippocampal mossy fiber

SLC4A8 TNN

5.26e-0471062GO:0097457
GeneOntologyCellularComponentasymmetric synapse

SLC4A8 MAP2 ANKS1B GRIA3 GRIA4 ALS2 CSMD2 ITPR1 NOS1

7.22e-044771069GO:0032279
GeneOntologyCellularComponentcytoplasmic vesicle membrane

GAD2 SLC4A8 ZMPSTE24 PSEN1 TMED7 GRIA3 GRIA4 TLR6 ITPR1 PIKFYVE CMTM6 TH PTPRC SBF2 SEC23IP SLC27A2

8.85e-04130710616GO:0030659
GeneOntologyCellularComponentglutamatergic synapse

SLC4A8 PSEN1 MAP2 ANKS1B ANO1 GRIA3 NCAM1 GRIA4 ALS2 CSMD2 TENM3 NOS1

8.89e-0481710612GO:0098978
GeneOntologyCellularComponentintercellular canaliculus

DPP4 ABCC2

8.96e-0491062GO:0046581
GeneOntologyCellularComponentvesicle membrane

GAD2 SLC4A8 ZMPSTE24 PSEN1 TMED7 GRIA3 GRIA4 TLR6 ITPR1 PIKFYVE CMTM6 TH PTPRC SBF2 SEC23IP SLC27A2

1.02e-03132510616GO:0012506
GeneOntologyCellularComponentdendritic spine

ANKS1B GRIA3 GRIA4 ALS2 P2RX3 NOS1

1.47e-032421066GO:0043197
GeneOntologyCellularComponentneuron spine

ANKS1B GRIA3 GRIA4 ALS2 P2RX3 NOS1

1.63e-032471066GO:0044309
GeneOntologyCellularComponentpostsynaptic density

MAP2 ANKS1B GRIA3 GRIA4 ALS2 CSMD2 ITPR1 NOS1

2.11e-034511068GO:0014069
GeneOntologyCellularComponentdynein complex

DNAH10 DNAH14 CFAP70

2.61e-03541063GO:0030286
GeneOntologyCellularComponentFAR/SIN/STRIPAK complex

PDCD10 STK25

3.30e-03171062GO:0090443
GeneOntologyCellularComponentnuclear inner membrane

ZMPSTE24 ITPR1 DPY19L4

3.35e-03591063GO:0005637
GeneOntologyCellularComponentcanonical inflammasome complex

NAIP MEFV

3.70e-03181062GO:0061702
GeneOntologyCellularComponentpostsynaptic specialization

MAP2 ANKS1B GRIA3 GRIA4 ALS2 CSMD2 ITPR1 NOS1

4.09e-035031068GO:0099572
DomainTHRAP3_BCLAF1

BCLAF3 THRAP3

8.66e-0531012IPR029199
DomainTHRAP3_BCLAF1

BCLAF3 THRAP3

8.66e-0531012PF15440
Domain-

GTF2IRD2B GTF2IRD2

1.73e-04410123.90.1460.10
DomainCu-oxidase_2

F8 HEPHL1

1.73e-0441012IPR011706
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.73e-0441012PS51139
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.73e-0441012PF02946
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.73e-0441012IPR004212
DomainCu-oxidase_2

F8 HEPHL1

1.73e-0441012PF07731
DomainCu-oxidase_3

F8 HEPHL1

2.86e-0451012IPR011707
DomainMULTICOPPER_OXIDASE1

F8 HEPHL1

2.86e-0451012PS00079
DomainCu_oxidase_CS

F8 HEPHL1

2.86e-0451012IPR033138
DomainCu-oxidase_3

F8 HEPHL1

2.86e-0451012PF07732
DomainRIH_assoc-dom

RYR2 ITPR1

4.28e-0461012IPR013662
DomainFAD_binding_1

MTRR NOS1

4.28e-0461012PF00667
Domain-

MTRR NOS1

4.28e-04610121.20.990.10
DomainIns145_P3_rec

RYR2 ITPR1

4.28e-0461012PF08709
DomainCu_oxidase_Cu_BS

F8 HEPHL1

4.28e-0461012IPR002355
DomainRIH_assoc

RYR2 ITPR1

4.28e-0461012PF08454
DomainRIH_dom

RYR2 ITPR1

4.28e-0461012IPR000699
DomainIns145_P3_rcpt

RYR2 ITPR1

4.28e-0461012IPR014821
DomainRyanodine_recept-rel

RYR2 ITPR1

4.28e-0461012IPR015925
DomainFAD-binding_1

MTRR NOS1

4.28e-0461012IPR003097
Domain-

RYR2 ITPR1

4.28e-04610121.25.10.30
DomainRYDR_ITPR

RYR2 ITPR1

4.28e-0461012PF01365
DomainNADPH_Cyt_P450_Rdtase_dom3

MTRR NOS1

4.28e-0461012IPR023173
DomainFlavodoxin/NO_synth

MTRR NOS1

7.94e-0481012IPR008254
DomainFlavdoxin-like

MTRR NOS1

7.94e-0481012IPR001094
DomainFLAVODOXIN_LIKE

MTRR NOS1

7.94e-0481012PS50902
DomainFlavodoxin_1

MTRR NOS1

7.94e-0481012PF00258
DomainMIR

RYR2 ITPR1

1.27e-03101012PF02815
DomainMIR_motif

RYR2 ITPR1

1.27e-03101012IPR016093
Domain-

MTRR NOS1

1.27e-031010123.40.50.360
DomainMIR

RYR2 ITPR1

1.27e-03101012PS50919
DomainMIR

RYR2 ITPR1

1.27e-03101012SM00472
DomainFlavoprotein-like_dom

MTRR NOS1

1.27e-03101012IPR029039
DomainFlavoprot_Pyr_Nucl_cyt_Rdtase

MTRR NOS1

1.27e-03101012IPR001709
DomainOxRdtase_FAD/NAD-bd

MTRR NOS1

1.84e-03121012IPR001433
DomainNAD_binding_1

MTRR NOS1

1.84e-03121012PF00175
DomainProt-tyrosine_phosphatase-like

STYXL2 PTPN14 PTPRC SBF2

2.05e-03991014IPR029021
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH14

2.53e-03141012IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH14

2.53e-03141012IPR024743
Domain-

F8 HEPHL1

2.53e-031410122.60.40.420
DomainMT

DNAH10 DNAH14

2.53e-03141012PF12777
DomainAAA_8

DNAH10 DNAH14

2.53e-03141012PF12780
DomainDHC_fam

DNAH10 DNAH14

2.90e-03151012IPR026983
DomainDynein_heavy

DNAH10 DNAH14

2.90e-03151012PF03028
DomainDynein_heavy_dom

DNAH10 DNAH14

2.90e-03151012IPR004273
DomainLig_chan-Glu_bd

GRIA3 GRIA4

4.19e-03181012PF10613
DomainGlu/Gly-bd

GRIA3 GRIA4

4.19e-03181012IPR019594
DomainLig_chan-Glu_bd

GRIA3 GRIA4

4.19e-03181012SM00918
DomainIontro_rcpt

GRIA3 GRIA4

4.19e-03181012IPR001320
DomainIono_rcpt_met

GRIA3 GRIA4

4.19e-03181012IPR001508
DomainLig_chan

GRIA3 GRIA4

4.19e-03181012PF00060
DomainPBPe

GRIA3 GRIA4

4.19e-03181012SM00079
DomainFd_Rdtase_FAD-bd

MTRR NOS1

4.66e-03191012IPR017927
DomainFAD_FR

MTRR NOS1

4.66e-03191012PS51384
DomainRiboflavin_synthase-like_b-brl

MTRR NOS1

4.66e-03191012IPR017938
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

GPR19 ZMPSTE24 ANKS1B GRIA3 GRIA4 CEP128 ALG2 RYR2 GTF2IRD2B WDR75 TNN SEC23IP GTF2IRD2 DDX23 PDIA2 ABCC2 MAPK6 THRAP3 ATP5F1C

6.97e-0814421061935575683
Pubmed

Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.

GRIA3 NCAM1 GRIA4

2.74e-07510639482932
Pubmed

Myenteric expression of nerve growth factor and the p75 neurotrophin receptor regulate axonal remodeling as a consequence of colonic inflammation in mice.

MAP2 TH NOS1

1.52e-068106326073142
Pubmed

Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.

GAD2 GRIA3 TH TACR3 NOS1

1.99e-0667106516987237
Pubmed

Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain.

MAP2 NCAM1 NOS1

2.28e-069106312798291
Pubmed

Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway.

GAD2 NCAM1 TH

2.28e-069106315611992
Pubmed

Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.

GAD2 ANO1 TH NOS1

2.74e-0632106433288908
Pubmed

Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb.

GAD2 NCAM1 TH

7.70e-0613106318024993
Pubmed

Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes.

DPP4 PTPRC

9.20e-06210621680916
Pubmed

Dopamine triggers heterosynaptic plasticity.

GAD2 TH

9.20e-062106223595734
Pubmed

Exposure to cocaine regulates inhibitory synaptic transmission from the ventral tegmental area to the nucleus accumbens.

GAD2 TH

9.20e-062106223918773
Pubmed

Elimination of redundant synaptic inputs in the absence of synaptic strengthening.

GRIA3 GRIA4

9.20e-062106222090494
Pubmed

Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells.

ANO1 LRRC8A

9.20e-062106233476655
Pubmed

PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress.

PDCD10 STK25

9.20e-062106222652780
Pubmed

The gain-of-function enhancement of IP3-receptor channel gating by familial Alzheimer's disease-linked presenilin mutants increases the open probability of mitochondrial permeability transition pore.

PSEN1 ITPR1

9.20e-062106227184076
Pubmed

Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS.

SLC4A8 MAP2

9.20e-062106218359573
Pubmed

Association of CD26 with CD45RA outside lipid rafts attenuates cord blood T-cell activation.

DPP4 PTPRC

9.20e-062106214525771
Pubmed

The neuronal nitric oxide synthase (nNOS) gene contributes to the regulation of tyrosine hydroxylase (TH) by cocaine.

TH NOS1

9.20e-062106219429176
Pubmed

IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels.

ANO1 ITPR1

9.20e-062106237851027
Pubmed

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.

PDCD10 STK25

9.20e-062106220592472
Pubmed

Kinetic properties of human AMPA-type glutamate receptors expressed in HEK293 cells.

GRIA3 GRIA4

9.20e-062106212670305
Pubmed

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing.

GRIA3 GRIA4

9.20e-06210627992055
Pubmed

Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.

PSEN1 ITPR1

9.20e-062106224828645
Pubmed

Nitric oxide affects the phosphorylation state of microtubule-associated protein 2 (MAP-2) and neurofilament: an immunocytochemical study in the brain of rats and neuronal nitric oxide synthase (nNOS)-knockouts.

MAP2 NOS1

9.20e-062106211829530
Pubmed

Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines.

PSEN1 RYR2

9.20e-062106224029002
Pubmed

Nitric oxide signaling modulates synaptic transmission during early postnatal development.

GAD2 NOS1

9.20e-062106221282319
Pubmed

Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4.

GRIA3 GRIA4

9.20e-062106218316356
Pubmed

Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice.

PSEN1 MAP2

9.20e-062106215519767
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

9.20e-062106215388857
Pubmed

GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse.

GRIA3 GRIA4

9.20e-062106221690196
Pubmed

Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains.

GAD2 MAP2 TH

9.77e-0614106323751821
Pubmed

Critical role of GFRα1 in the development and function of the main olfactory system.

GAD2 NCAM1 TH

1.22e-0515106323197722
Pubmed

Generation and characterization of Tmeff2 mutant mice.

GAD2 TH NOS1

1.22e-0515106322828515
Pubmed

IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone.

GAD2 NCAM1 TH

1.22e-0515106319712103
Pubmed

Defining the membrane proteome of NK cells.

DPP4 ZMPSTE24 NCAM1 ALG2 ITPR1 CEP350 CMTM6 EEF1G PTPRC PMVK KIF15 CLPTM1 LRRC8A ATP5F1C

1.28e-0511681061419946888
Pubmed

DLX5 regulates development of peripheral and central components of the olfactory system.

GAD2 NCAM1 TH

1.81e-0517106312533617
Pubmed

Regional cytoarchitecture of the adult and developing mouse enteric nervous system.

GAD2 TH NOS1

1.81e-0517106336070775
Pubmed

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.

GAD2 MAP2 NCAM1

2.17e-0518106318599437
Pubmed

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

CMTM4 CMTM6

2.76e-053106228813410
Pubmed

Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer.

CMTM4 CMTM6

2.76e-053106235983975
Pubmed

Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III.

PDCD10 STK25

2.76e-053106223665169
Pubmed

Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patients.

GRIA3 GRIA4

2.76e-053106218163426
Pubmed

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.

PSEN1 NCAM1

2.76e-053106216006137
Pubmed

Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells.

GRIA3 GRIA4

2.76e-053106212172541
Pubmed

Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes.

RYR2 NOS1

2.76e-053106218077344
Pubmed

Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease.

NCAM1 PTPRC

2.76e-053106237973964
Pubmed

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.

PSEN1 ITPR1

2.76e-053106221784978
Pubmed

CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment.

CMTM4 CMTM6

2.76e-053106235958549
Pubmed

The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells.

GRIA3 GRIA4

2.76e-053106228397107
Pubmed

Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6.

RYR2 ITPR1

2.76e-053106212754204
Pubmed

Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer.

PDCD10 STK25

2.76e-053106225550858
Pubmed

Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons.

GAD2 PSEN1

2.76e-053106233302995
Pubmed

CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization.

PDCD10 STK25

2.76e-053106221561863
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

2.76e-053106215100712
Pubmed

KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.

KIF15 DEK

2.76e-053106234280614
Pubmed

Amygdala Corticofugal Input Shapes Mitral Cell Responses in the Accessory Olfactory Bulb.

GAD2 NOS1

2.76e-053106229911171
Pubmed

Synaptic AMPA receptor plasticity and behavior.

GRIA3 GRIA4

2.76e-053106219217372
Pubmed

Intracellular calcium release channel expression during embryogenesis.

RYR2 ITPR1

2.76e-05310629986730
Pubmed

Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

PTPRC THRAP3

2.76e-053106220932480
Pubmed

Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke.

PSEN1 PTPRC

2.76e-053106230519973
Pubmed

Dual embryonic origin of the mammalian enteric nervous system.

MAP2 TH NOS1

3.02e-0520106330472119
Pubmed

Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina.

GAD2 TH NOS1

3.02e-0520106316026391
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

GAD2 NCOA4 NUDT13 SEC23IP NT5C2 CFAP70 ABCC2 ATP5F1C

4.18e-05415106816385451
Pubmed

Polymorphisms in innate immunity genes and risk of childhood leukemia.

DEFB118 SOCS3 TLR6 MEFV PDCD10 NOS1

4.19e-05206106620438785
Pubmed

Risk of meningioma and common variation in genes related to innate immunity.

DEFB118 SOCS3 TLR6 MEFV PDCD10 NOS1

4.30e-05207106620406964
Pubmed

Common variation in genes related to innate immunity and risk of adult glioma.

DEFB118 SOCS3 TLR6 MEFV PDCD10 NOS1

4.42e-05208106619423540
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

GAD2 SLC4A8 MAP2 ANKS1B DGKG GRIA3 NCAM1 GRIA4 RYR2 ITPR1 EEF1G NOS1 THRAP3

4.43e-0511391061336417873
Pubmed

Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification.

GAD2 TH TACR3

4.66e-0523106331850343
Pubmed

Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.

GAD2 MAP2 TH

5.32e-0524106329086765
Pubmed

Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption.

GAD2 NOS1

5.50e-054106232841600
Pubmed

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.

GRIA3 GRIA4

5.50e-054106228608780
Pubmed

AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus.

GRIA3 GRIA4

5.50e-05410629221927
Pubmed

Interaction proteomics reveals brain region-specific AMPA receptor complexes.

GRIA3 GRIA4

5.50e-054106225337787
Pubmed

Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors.

GRIA3 GRIA4

5.50e-054106217828255
Pubmed

The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization.

GRIA3 GRIA4

5.50e-054106224652293
Pubmed

Endosomal phosphoinositides and human diseases.

PIKFYVE SBF2

5.50e-054106218429927
Pubmed

Evolution of general transcription factors.

GTF2IRD2B GTF2IRD2

5.50e-054106223229069
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR2 ITPR1

5.50e-054106223413940
Pubmed

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

GTF2IRD2B GTF2IRD2

5.50e-054106222899722
Pubmed

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.

GRIA3 GRIA4

5.50e-054106210027300
Pubmed

AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks.

GRIA3 GRIA4

5.50e-054106212692557
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR2 ITPR1

5.50e-05410629607712
Pubmed

Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.

GRIA3 GRIA4

5.50e-054106212125045
Pubmed

Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp.

RCAN1 SOCS3

5.50e-054106211970967
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR2 ITPR1

5.50e-054106219120137
Pubmed

The pheromone darcin drives a circuit for innate and reinforced behaviours.

GAD2 NOS1

5.50e-054106231996852
Pubmed

A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing.

GRIA3 GRIA4

5.50e-054106210688364
Pubmed

Association of existing and new candidate genes for anxiety, depression and personality traits in older people.

PSEN1 NOS1

5.50e-054106220052609
Pubmed

Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons.

GAD2 TH

5.50e-054106231582313
Pubmed

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion.

GAD2 TH

5.50e-054106229472620
Pubmed

Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA.

GAD2 LRRC8A

5.50e-054106236681074
Pubmed

Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family.

GRIA3 GRIA4

5.50e-054106217409242
Pubmed

NCAM1, TACR1 and NOS genes and temperament: a study on suicide attempters and controls.

NCAM1 NOS1

5.50e-054106221577011
Pubmed

TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.

GTF2IRD2B GTF2IRD2

5.50e-054106217823943
Pubmed

Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit.

GRIA3 GRIA4

5.50e-054106214561864
Pubmed

Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling.

RYR2 NOS1

5.50e-054106232580946
Pubmed

Chromosomal localization of human glutamate receptor genes.

GRIA3 GRIA4

5.50e-05410621319477
Pubmed

nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages.

PSEN1 NOS1

5.50e-054106229577585
Pubmed

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.

RYR2 NOS1

5.50e-054106222798524
Pubmed

Neuronal nitric oxide synthase gene inactivation reduces the expression of vasopressin in the hypothalamic paraventricular nucleus and of catecholamine biosynthetic enzymes in the adrenal gland of the mouse.

TH NOS1

5.50e-054106217853069
GeneFamilyGlutamate ionotropic receptor AMPA type subunits

GRIA3 GRIA4

9.34e-0547221200
GeneFamilyCKLF like MARVEL transmembrane domain containing

CMTM4 CMTM6

4.31e-048722978
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

DPP4 GPR19 MYO10 SOCS3 ITPR1 CEP350 KIF15 RBM27 MAPK6 MBD4 PDCD10 DEK

1.16e-0565610412M18979
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_0.5H_BMDC_DN

GRIA4 NUDT13 ALG2 TK1 DEK NOS1 SLC27A2

1.54e-052001047M3960
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

PSEN1 RCAN1 TMED7 DHDDS DPP3 TLR6 CEP350 CMTM6 PRDM10 EIF2B1 NT5C2 MTRR TMEM131 MBD4 PDCD10 ATP5F1C

2.33e-05121510416M41122
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_200

MAP2 ANO1 MUC16 GRIA3 LGR5 RYR2 TAF7L

5.15e-061431007gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_200
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_100

ANO1 MUC16 GRIA3 LGR5 TAF7L

3.81e-05801005gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_100
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TDRD5 DNAH10 ANKS1B OTOGL TACR3 ABCC2 HEPHL1

1.24e-071621067bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

ARHGEF28 MAP2 ANKS1B ANO1 DGKG RYR2 ITPR1

3.42e-07188106734e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

TTC39B SLC4A8 MYO10 CEP128 GRHL2 CASZ1 ITPR1

3.42e-071881067b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ARHGEF28 MUC16 CSMD2 GRHL2 DNAH14 OTOGL NOS1

4.37e-071951067d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ARHGEF28 MUC16 CSMD2 GRHL2 DNAH14 OTOGL NOS1

4.37e-07195106719853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 DGKG STYXL2 CSMD2 RYR2 ITPR1

5.57e-0618610664780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

ARHGEF28 MAP2 ANKS1B ANO1 DGKG ITPR1

6.11e-0618910666b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR19 SLC4A8 COG7 ANO1 DGKG TACR3

6.30e-0619010661ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Tacr3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GAD2 CASZ1 TACR3 NOS1 SLC27A2

6.35e-06109106592ab514fd8d6711f55de9671fc80da22b20ad248
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR19 SLC4A8 COG7 ANO1 DGKG OTOGL

6.49e-061911066ff7874cc005760a8f3b2e8072fbe418b6bfacaa8
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC4A8 DNAH10 ADAMTSL3 RYR2 KIF15

1.61e-05132106502491930097b75aaeedab9e8200711b0dc610944
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Htr1d|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DGKG CASZ1 TACR3 NOS1 SLC27A2

2.07e-051391065fe1657ef9aeda7c530dc7febcd3dcd0e1d5f8a48
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCAM1 GRIA4 BCLAF3 PTPN14 TNN

2.37e-051431065b4ed3855652fdf32f97cb7c18cab4f4f4c24d5c7
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIA3 NCAM1 F8 PTPN14 OTOGL

4.97e-051671065a4a795751644b22af616335379e64ae95175180c
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 GRIA4 ADAMTSL3 RYR2 OTOGL

5.41e-0517010655570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 MAP2 ANO1 DGKG NCAM1

6.20e-051751065d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 DGKG LGR5 RYR2 OTOGL

6.20e-051751065316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 DGKG LGR5 RYR2 OTOGL

6.20e-051751065a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 MAP2 ANO1 DGKG NCAM1

6.20e-051751065cf15465855602ba135752c18755e3e058dbd42ec
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR19 SLC4A8 MAP2 ANKS1B NOS1

6.37e-051761065116741fef5895ca85057d2d31eca9eba5764ab44
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR19 SLC4A8 MAP2 ANKS1B NOS1

6.37e-0517610655b707f58d164ee7a6a527dd5d053472ce9a631c1
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSEN1 DGKG MEFV PRDM10 KIF15

6.37e-05176106590f8bb11f339f67f08692a0c33dd420f5cda2861
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

NAIP TLR6 CSMD2 MEFV TENM3

6.90e-051791065cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 COG7 ANKS1B ANO1 GRIA3

6.90e-051791065e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO10 DGKG ADAMTSL3 RYR2 OTOGL

7.27e-051811065451b87ac95154bb80018b8dd245b4a6389d81411
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOCS3 GRIA3 NCAM1 ITPR1 SLC27A2

7.47e-051821065f5f42e23832d0210560009ce6fd8eee89751e252
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

ARHGEF28 ANKS1B ANO1 DGKG ITPR1

7.66e-051831065818fd886e0188091310825f9145fa53328f2c979
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

TH KIF15 TK1 TAF7L DEK

7.66e-051831065a48a6313f2f144586951cece97ec31f6d72361df
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

MAP2 CMTM4 ANKS1B GRHL2 DNAH14

7.66e-051831065942530449e9c6583705eeb8f6f12621daea57252
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

ARHGEF28 ANKS1B ANO1 DGKG ITPR1

7.66e-051831065cae2ee08f985a6f005b4b8e959e465350315156a
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP4 CEP350 PTPRC DDX23 THRAP3

7.86e-0518410651154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARHGEF28 DGKG GRHL2 TACR3 SLC27A2

7.86e-051841065fa4915b0498f3069fd5ef497286445528f75187e
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO10 ANO1 DGKG ADAMTSL3 RYR2

8.06e-051851065a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DPP4 ARHGEF28 LGR5 TENM3 ABCC2

8.06e-0518510651d874608aa2062024323512f68889219471b2f00
ToppCelldroplet-Lung-nan-18m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 RBP2 GRHL2 TNN CFAP70

8.27e-051861065740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

NCOA4 LGR5 CEP350 PRDM10 TMEM131

8.27e-05186106503db813598b67b1e08f759758a1c2023396921fa
ToppCelldroplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 RBP2 GRHL2 TNN CFAP70

8.27e-0518610655ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO10 DGKG ADAMTSL3 RYR2 OTOGL

8.48e-05187106586250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO10 ANO1 DGKG ADAMTSL3 RYR2

8.48e-051871065a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellmild_COVID-19-Plasmablast|World / disease group, cell group and cell class (v2)

IGHV2-70 CEP128 IGHV2-70D KIF15 TK1

8.70e-0518810659a5ba6abdc307402301dae25db2a5f3e0d576417
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GRHL2 CASZ1 ITPR1 CFAP70 NOS1

8.70e-0518810652ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SLC4A8 ARHGEF28 DGKG GRHL2 SLC27A2

8.92e-0518910655d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCelldroplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF28 RBP2 F8 PTPN14 TENM3

9.14e-051901065e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCelldroplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF28 RBP2 F8 PTPN14 TENM3

9.14e-051901065f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCelldroplet-Lung-18m-Endothelial-lymphatic_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF28 RBP2 F8 PTPN14 TENM3

9.14e-051901065b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MAP2 GRIA4 ADAMTSL3 RYR2 OTOGL

9.14e-05190106510125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

GAD2 RCAN1 USP11 GRIA3 NCAM1

9.37e-0519110653379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 MAP2 COG7 ANO1 DGKG

9.37e-0519110655c1f5b6c115b1b27b4a7467a6550ce43c01cf6d0
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANKS1B ANO1 DGKG ADAMTSL3 RYR2

9.37e-05191106508042952431ca1a6fd7dfc13f36eb28643979598
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 DGKG ADAMTSL3 RYR2 ITPR1

9.37e-0519110657853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 DGKG GRIA3 ADAMTSL3 RYR2

9.60e-051921065992d08092edbc68c47b945deb8708379738c239a
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR19 SLC4A8 COG7 ANO1 GRHL2

9.60e-05192106588472b99970ba0decbf87164fc241a1c77b3b389
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MAP2 MYO10 ANO1 RYR2 TENM3

9.60e-05192106562904f94dfce430456f05066522cbf9bd29f4d7e
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 MAP2 COG7 ANO1 DGKG

9.84e-0519310651043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 ANO1 GRIA4 ADAMTSL3 NOS1

9.84e-051931065294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 MAP2 COG7 ANO1 DGKG

9.84e-0519310650266a4fdf436d83ec1d9392abba8c6ec5166970a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 ANO1 GRIA4 ADAMTSL3 NOS1

9.84e-0519310653d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 ADAMTSL3 LGR5 TENM3 NOS1

9.84e-051931065e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP4 IGHV2-70 GRIA4 LGR5 PDIA2

1.01e-0419410652f6e62a4ec8707bd5a16c0734c5131af55207ea2
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF28 MAP2 MYO10 RBP2 CMTM6

1.01e-041941065a3adcdc8b87332e8beb9bcd70cf36424af10633d
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ANO1 GRIA4 CEP128 KIF15 TK1

1.01e-041941065590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP4 LGR5 P2RX3 KIF15 THRAP3

1.01e-0419410658ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DPP4 MAP2 GRIA3 GRIA4 PTPN14

1.01e-0419410658b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR19 SLC4A8 COG7 ANO1 GRHL2

1.01e-04194106552ecec2618c3bb5fdd7fb06b5a40bd6f0aedfe1d
ToppCellCOVID-19-Lymphoid-Tregs|Lymphoid / Condition, Lineage and Cell class

SAMD9 SOCS3 ANKS1B CMTM6 CARD6

1.03e-0419510659ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF28 GRHL2 CASZ1 DNAH14 PTPN14

1.03e-0419510656477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DGKG GRIA3 NCAM1 TACR3 NOS1

1.06e-041961065f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DGKG GRIA3 NCAM1 TACR3 NOS1

1.06e-041961065671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR19 SLC4A8 MAP2 NCAM1 NOS1

1.11e-04198106550504a3871f76d6a5b439a56450d7770f4501eb0
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC4A8 ARHGEF28 MUC16 FER1L6-AS1 SLC27A2

1.11e-041981065af07a970afaa435c6433bb5c1cbff4c67af350c7
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD2 SAMD9 ADAMTSL3 TENM3 NOS1

1.16e-042001065a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGEF28 ANO1 MUC16 GRHL2 SBF2

1.16e-042001065682960e28542a3d6c119047cd0131941932cfdea
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD2 SAMD9 ADAMTSL3 TENM3 NOS1

1.16e-04200106533b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGEF28 CMTM4 MUC16 GRHL2 CASZ1

1.16e-042001065d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellTracheal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ADAMTSL3 RYR2 OTOGL PDIA2

1.16e-0420010658158f4eaeff945a6788c8e732b7a1b0d78052a06
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC4A8 ARHGEF28 ANO1 MUC16 CASZ1

1.16e-042001065ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCellILEUM-inflamed-(1)_Highly_activated_T_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PMVK KIF15 TK1 DEK SLC27A2

1.16e-0420010656ff811fdfe49b5b0aea0e88fae80bfaaf40eb7c4
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD2 SAMD9 ADAMTSL3 TENM3 NOS1

1.16e-0420010659719fabddc34051949468a7520289e3c750de4f8
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGEF28 ANO1 MUC16 GRHL2 CASZ1

1.16e-0420010650eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC4A8 ARHGEF28 ANO1 MUC16 CASZ1

1.16e-04200106585c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Cadm2+,_not_selective)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

P2RX3 TNN TAF7L

1.46e-044310637027858b46c0aabec290ed3888201a1b39e10552
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Cadm2+,_not_selective)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

P2RX3 TNN TAF7L

1.46e-044310630282410243ba125ec13fd6af737ddf952e493280
ToppCellLPS-IL1RA-Unknown-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPR19 RCAN1 ADAMTSL3 KIF15

1.82e-041181064aefad0b35aff980b6a2a98057735442e8a65ab04
ToppCellLPS-IL1RA-Unknown|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPR19 RCAN1 ADAMTSL3 KIF15

1.82e-0411810646cb4063b83f867b782080ce5b1199b51bb277f2a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GAD2 P2RX3 TENM3 NOS1

1.94e-041201064a4e3f9a83bc52ccc75bcd64b1be4e2c5441f6d1a
DrugN-methyl-DL-aspartic acid

GAD2 PSEN1 MAP2 GRIA3 NCAM1 GRIA4 RYR2 ITPR1 PIKFYVE TH MTRR TACR3 MAPK6 NOS1

1.51e-0665510314CID000004376
DrugKainic Acid

GAD2 MAP2 NAIP GRIA3 NCAM1 GRIA4 TH NOS1

2.86e-061941038ctd:D007608
DrugAC1L1DXE

PSEN1 DHDDS RYR2 ITPR1 PIKFYVE TH P2RX3 TACR3 NOS1

8.78e-062991039CID000002548
DiseaseNeurotmesis

P2RX3 NOS1

1.21e-0521032C1142379
DiseaseDepressive disorder

DPP4 PSEN1 GRIA3 NCAM1 CSMD2 TH NOS1

7.14e-052891037C0011581
DiseaseMental Depression

DPP4 PSEN1 GRIA3 NCAM1 CSMD2 TH

2.73e-042541036C0011570
Diseasebrain ischemia (biomarker_via_orthology)

MAP2 NAIP TH NOS1

4.58e-041021034DOID:2316 (biomarker_via_orthology)
Diseasecerebral cavernous malformation (implicated_via_orthology)

PDCD10 STK25

6.50e-04111032DOID:0060669 (implicated_via_orthology)
Diseasenervous system disorder

MTRR ABCC2 NOS1

8.52e-04531033C0027765
Diseasecortisol measurement, response to corticosteroid, response to synacthen

ANKS1B NOS1

9.18e-04131032EFO_0005843, EFO_0009175, GO_0031960
Diseaseacute lymphoblastic leukemia (is_implicated_in)

MEFV MTRR ABCC2

9.50e-04551033DOID:9952 (is_implicated_in)
Diseaselow density lipoprotein cholesterol measurement, response to selective serotonin reuptake inhibitor

NCAM1 CSMD2

1.23e-03151032EFO_0004611, EFO_0005658
Diseaseunipolar depression, response to escitalopram, response to citalopram, mood disorder

DGKG NT5C2

1.23e-03151032EFO_0003761, EFO_0004247, EFO_0006329, EFO_0007871
Diseaseresponse to opioid

RCAN1 MUC16 SEC23IP

1.28e-03611033EFO_0008541
Diseasealcohol consumption measurement

DPP4 SLC4A8 PSEN1 RCAN1 ANKS1B DHDDS NCAM1 DPP3 RBM27 EIF2B1 MAPK6 MBD4

1.31e-03124210312EFO_0007878
DiseaseAlpha ketoglutarate measurement

SAMD9 TENM3

1.40e-03161032EFO_0010457
Diseasecentral nervous system disease (implicated_via_orthology)

GRIA3 GRIA4

1.40e-03161032DOID:331 (implicated_via_orthology)
Diseasecholangiocarcinoma (is_marker_for)

SOCS3 MUC16 NCAM1

1.47e-03641033DOID:4947 (is_marker_for)
Diseaseend stage renal disease (implicated_via_orthology)

ABCC2 NOS1

2.20e-03201032DOID:783 (implicated_via_orthology)
DiseaseParkinson's disease (is_implicated_in)

TH MTRR NOS1

2.41e-03761033DOID:14330 (is_implicated_in)
DiseaseLewy Body Disease

MAP2 TH

2.66e-03221032C0752347
DiseaseMood Disorders

GAD2 MAP2 NCAM1 TH

2.89e-031681034C0525045
Diseasefrailty measurement

NCAM1 MAPK6

2.91e-03231032EFO_0009885
DiseaseColorectal Neoplasms

LGR5 TK1 ZNF432 MTRR ABCC2

2.91e-032771035C0009404
DiseaseNerve Degeneration

PSEN1 TH NOS1

3.10e-03831033C0027746
DiseaseParkinson Disease

MAP2 TH NOS1

3.32e-03851033C0030567

Protein segments in the cluster

PeptideGeneStartEntry
DFSSSRAITLYKDKR

TDRD5

911

Q8NAT2
FLRSKKSSEEITQYI

NAIP

226

Q13075
SEYQVRKSSEKTDFI

ADAM5

131

Q6NVV9
TKYRTKSFKGDRTFL

CEP128

1016

Q6ZU80
KYVSDFTSTLQSIRK

COG7

431

P83436
KITFDRFKTEVNYDT

CSMD2

791

Q7Z408
TRNRTSVDFKDTDYK

NT5C2

506

P49902
TERRFYSKLSDIKSQ

ALS2

701

Q96Q42
SEDTLSKRARFSKYE

CASZ1

226

Q86V15
AKTITKDSIYDSFDR

GPR19

381

Q15760
FRLTDKEKSSICYLS

DENND6B

66

Q8NEG7
KFESLFRTYDKDITF

RCAN1

86

P53805
TSGFVDKLFESLYTK

RBM27

61

Q9P2N5
RSLKKYSFESIREES

LRRC8A

346

Q8IWT6
KSESEKYKVSRTFSF

ARHGEF28

611

Q8N1W1
EDLSTFAYITKDLKS

ANKS1B

1141

Q7Z6G8
TQRFTYSEKTTLFSK

MUC16

4126

Q8WXI7
YVVKSFDRSTKVIDF

GAD2

121

Q05329
SEEKESSVLSKLKFY

HSFY1

161

Q96LI6
DKELSSVKLEYSSFK

KIF15

811

Q9NS87
ERLFIYSSKDSSKRL

FER1L6-AS1

76

Q8NA97
FLTKESKLRIYYTTE

ITPR1

2226

Q14643
SDKAFFDLKTSKRVY

SBF2

1811

Q86WG5
DDKFYSTSLKTRLTI

IGHV2-70D

76

A0A0C4DH43
KKAFLRALVDYTSDS

MTRR

381

Q9UBK8
AVAAKKRFSVYVTES

EIF2B1

141

Q14232
STKEFFRRSKIAVYE

GRIA3

686

P42263
STKEFFRRSKIAVYE

GRIA4

676

P48058
EFVKYSKSFSDTLKT

PDCD10

166

Q9BUL8
TSYLDKFFSRKEDTE

MAPK6

626

Q16659
FTYESLKKTKCREFV

MYO10

1671

Q9HD67
LDSEVTSKLKSYEFR

DPP3

226

Q9NY33
TADSRKTYTLTDYLK

DPP4

36

P27487
VYKSRTKRSSTTKLY

ABCC2

51

Q92887
TSVVYKKTLFVEFTD

F8

61

P00451
FVEKSTKYFSETLRS

MEFV

566

O15553
DKDSFFDSKTRSTIV

ANO1

236

Q5XXA6
FDSKTRSTIVYEILK

ANO1

241

Q5XXA6
DDKYYSTSLKTRLTI

IGHV2-70

76

P01814
IEYKSTRDLETFSKF

PDIA2

476

Q13087
KTFKPRITSTDYDSF

PRDM10

711

Q9NQV6
TVRFTTDYFEVSSKK

DEFB118

86

Q96PH6
TFLTKEDSAVFYELK

DDX23

766

Q9BUQ8
LVIKYAKDTRYSSSF

TK1

51

P04183
STYVTKTRYLFELKE

NUDT13

21

Q86X67
EERKSYKVRFNSVSS

NOS1

841

P29475
SRETSEKFKLLFQSY

NCOA4

321

Q13772
SEYSSKKIKDALTEF

DGKG

21

P49619
VTSSEDKRKTYSLAF

PIKFYVE

1031

Q9Y2I7
YSESFKDAATEKFRS

GRHL2

216

Q6ISB3
DVKKTVDTFRVASSY

BCLAF3

416

A2AJT9
DLETSEFFRDKKTSY

CARD6

141

Q9BX69
EFFRDKKTSYRETAL

CARD6

146

Q9BX69
VRDKYLKTTSFESQE

CFAP70

581

Q5T0N1
TYDLTERKDFIKTTV

DEK

356

P35659
EKDSTSIATEYSLKF

CEP350

1596

Q5VT06
YSKRSAEDIYKILTS

DPY19L4

621

Q7Z388
STEEVKRAFFSKSKE

DNAJC4

46

Q9NNZ3
AEKETLEYKTVRTFS

DNAH14

226

Q0VDD8
LEYKTVRTFSESLKS

DNAH14

231

Q0VDD8
LRAKTIVKFSDEYLT

MBD4

511

O95243
VRYTEFVDATFTKRK

HEPHL1

431

Q6MZM0
IFNKFRSVISYKTEE

ATP5F1C

186

P36542
STFVLDEFKRKYSNE

EEF1G

286

P26641
TEFQKRLSDFKLYES

GTF2IRD2

831

Q86UP8
TEFQKRLSDFKLYES

GTF2IRD2B

831

Q6EKJ0
SETFEKSRLYQLDKS

ZMPSTE24

61

O75844
YAFSIENFKRSKSEV

DHDDS

76

Q86SQ9
KFDEYIKRLASLSTV

DNAH10

2361

Q8IVF4
STAFTFRSSKEKLDV

RYR2

326

Q92736
ERGFSVKYSAKFETK

LGR5

661

O75473
FFIIFTDSSVKASKY

OTOGL

1331

Q3ZCN5
DFFTYETTKSVVVKS

P2RX3

6

P56373
ESLRTLDKKTFYKTA

TAF7L

161

Q5H9L4
VVATIKSVSFYTRKD

PSEN1

96

P49768
AKFSIYVDSKSELVT

TMEM217B

36

A0A494BZU4
FSSESYSSPFVKRDK

SAMD9

696

Q5K651
SLKKDDVSIYYVSRT

SLC27A2

171

O14975
KSVEESKITAVFYTF

OR5M1

266

Q8NGP8
SSATYGKFKVTTKFR

PTPN14

1031

Q15678
LSLSEYFSTFEKEKI

SEC23IP

656

Q9Y6Y8
FILSSTLKTFKTSRY

SLC4A8

706

Q2Y0W8
FIKVSSYDELELKTT

TACR3

376

P29371
RLLDTSTYKEAFRKD

PMVK

61

Q15126
TRYTKKTSFLTELID

STK25

271

O00506
KTKTTSTFRNYDVDF

RBP2

51

P50120
RSKAFDDIATYFSKK

SSX1

21

Q16384
YVTFLRSFSDKQKIS

ALG2

296

Q9H553
SFKDKSTYIESSTKV

CLPTM1

456

O96005
LDTFSYSTNVTVRKK

CMTM4

206

Q8IZR5
TPFYERVDTTKVKSS

CMTM6

91

Q9NX76
RVDTTKVKSSDFYIT

CMTM6

96

Q9NX76
EKYIFSDDSSQLTIK

NCAM1

261

P13591
FRVTAYKAVQEKSSS

THRAP3

521

Q9Y2W1
YRKKYTVVESFSSLL

TTC39B

206

Q5VTQ0
DFFQVASSKERYKLT

TNN

1176

Q9UQP3
YFFKKKTTSRFTLSS

WDR75

181

Q8IWA0
SLLRETESKSSSYKF

STYXL2

966

Q5VZP5
SESKYTKVASISFDA

TMEM131

381

Q92545
FLLKSFFSDKRTTTT

TMED7

206

Q9Y3B3
RLKTFSSKSEYQLVV

SOCS3

21

O14543
SVDFDRTTKTEKIYD

TENM3

1776

Q9P273
SIREEDFTYSKTTLK

TLR6

291

Q9Y2C9
DFTYSKTTLKALTIE

TLR6

296

Q9Y2C9
KYFETSALKEEATKS

MAP2

571

P11137
EELYSAAKFSVSTKA

ZNF432

171

O94892
LKYTESRKSFREKSV

ZNF530

211

Q6P9A1
TEKEPKTYTTFKCFS

ZNF280C

306

Q8ND82
KDTDKSSTYTLRVFE

PTPRC

1091

P08575
SSSRLSQYFEKFDVK

UHRF1BP1

306

Q6BDS2
FSYTKFSREKLDTLV

USP11

831

P51784
VYFVSESFSDAKDKL

TH

461

P07101
DFIFKTRYTAAKDSV

ADAMTSL3

316

P82987