Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	SLC7A9 TRPM6 LRRC8E SLC7A8 SLC43A2 CACNA1D CACNA1F CLPTM1L KCNH7 OSBPL2 SLC35C2 SLC5A7 TMEM87A RYR3 TPCN1	1.20e-04	1289	78	15	GO:0005215
GeneOntologyMolecularFunction	calcium channel activity	TRPM6 CACNA1D CACNA1F RYR3 TPCN1	1.51e-04	129	78	5	GO:0005262
GeneOntologyMolecularFunction	L-leucine transmembrane transporter activity	SLC7A8 SLC43A2	2.24e-04	6	78	2	GO:0015190
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM6 CACNA1D CACNA1F RYR3 TPCN1	3.13e-04	151	78	5	GO:0015085
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM6 CACNA1D CACNA1F KCNH7 TMEM87A RYR3 TPCN1	3.86e-04	343	78	7	GO:0005261
GeneOntologyMolecularFunction	bubble DNA binding	ABL1 WRN	4.15e-04	8	78	2	GO:0000405
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPM6 LRRC8E CACNA1D CACNA1F KCNH7 TMEM87A RYR3 TPCN1	4.21e-04	459	78	8	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPM6 CACNA1D CACNA1F KCNH7 SLC5A7 TMEM87A RYR3 TPCN1	4.59e-04	465	78	8	GO:0046873
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC7A9 SLC7A8 SLC43A2	5.49e-04	41	78	3	GO:0015175
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC7A9 TRPM6 LRRC8E SLC7A8 SLC43A2 CACNA1D CACNA1F KCNH7 SLC35C2 SLC5A7 TMEM87A RYR3 TPCN1	6.10e-04	1180	78	13	GO:0022857
GeneOntologyMolecularFunction	branched-chain amino acid transmembrane transporter activity	SLC7A8 SLC43A2	6.64e-04	10	78	2	GO:0015658
GeneOntologyMolecularFunction	sulfur amino acid transmembrane transporter activity	SLC7A9 SLC43A2	8.10e-04	11	78	2	GO:0000099
GeneOntologyMolecularFunction	channel activity	TRPM6 LRRC8E CACNA1D CACNA1F KCNH7 TMEM87A RYR3 TPCN1	1.01e-03	525	78	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPM6 LRRC8E CACNA1D CACNA1F KCNH7 TMEM87A RYR3 TPCN1	1.02e-03	526	78	8	GO:0022803
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1D CACNA1F	1.33e-03	14	78	2	GO:0008331
GeneOntologyMolecularFunction	gated channel activity	CACNA1D CACNA1F KCNH7 TMEM87A RYR3 TPCN1	1.96e-03	334	78	6	GO:0022836
GeneOntologyMolecularFunction	Wnt receptor activity	FZD1 FZD2	1.97e-03	17	78	2	GO:0042813
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR3 TPCN1	2.21e-03	18	78	2	GO:0015278
GeneOntologyMolecularFunction	four-way junction DNA binding	ABL1 WRN	2.47e-03	19	78	2	GO:0000400
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC7A9 SLC7A8 SLC43A2	2.71e-03	71	78	3	GO:0015179
GeneOntologyMolecularFunction	manganese ion binding	MGAT5 ABL1 WRN	2.71e-03	71	78	3	GO:0030145
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	TRPM6 CACNA1D CACNA1F KCNH7 SLC5A7 TMEM87A RYR3 TPCN1	3.07e-03	627	78	8	GO:0022890
GeneOntologyMolecularFunction	catalytic activity, acting on a glycoprotein	B4GALNT4 MGAT5	3.61e-03	23	78	2	GO:0140103
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TRPM6 LRRC8E CACNA1D CACNA1F KCNH7 SLC5A7 TMEM87A RYR3 TPCN1	3.70e-03	793	78	9	GO:0015075
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC7A8 SLC43A2 SLC5A7	4.21e-03	83	78	3	GO:0015101
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPM6 CACNA1D CACNA1F KCNH7 SLC5A7 TMEM87A RYR3 TPCN1	4.34e-03	664	78	8	GO:0008324
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC17 ZDHHC11	4.61e-03	26	78	2	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC17 ZDHHC11	4.61e-03	26	78	2	GO:0019707
GeneOntologyMolecularFunction	glycosyltransferase activity	GALNT15 B4GALNT4 MGAT5 TNKS2 ALG1L2	5.40e-03	288	78	5	GO:0016757
Domain	Ion_trans_dom	TRPM6 CACNA1D CACNA1F KCNH7 RYR3 TPCN1	6.99e-06	114	76	6	IPR005821
Domain	Ion_trans	TRPM6 CACNA1D CACNA1F KCNH7 RYR3 TPCN1	6.99e-06	114	76	6	PF00520
Domain	CAC1F_C	CACNA1D CACNA1F	4.89e-05	3	76	2	IPR031688
Domain	CAC1F_C	CACNA1D CACNA1F	4.89e-05	3	76	2	PF16885
Domain	GPR107-like	TMEM87B TMEM87A	9.75e-05	4	76	2	IPR009637
Domain	Lung_7-TM_R	TMEM87B TMEM87A	9.75e-05	4	76	2	PF06814
Domain	VDCC_L_a1su	CACNA1D CACNA1F	9.75e-05	4	76	2	IPR005446
Domain	VDCC_a1su_IQ	CACNA1D CACNA1F	3.39e-04	7	76	2	IPR014873
Domain	GPHH	CACNA1D CACNA1F	3.39e-04	7	76	2	PF16905
Domain	GPHH_dom	CACNA1D CACNA1F	3.39e-04	7	76	2	IPR031649
Domain	Ca_chan_IQ	CACNA1D CACNA1F	3.39e-04	7	76	2	SM01062
Domain	Ca_chan_IQ	CACNA1D CACNA1F	3.39e-04	7	76	2	PF08763
Domain	VDCCAlpha1	CACNA1D CACNA1F	7.20e-04	10	76	2	IPR002077
Domain	Frizzled	FZD1 FZD2	8.78e-04	11	76	2	IPR000539
Domain	Frizzled	FZD1 FZD2	8.78e-04	11	76	2	PF01534
Domain	Frizzled	FZD1 FZD2	8.78e-04	11	76	2	SM01330
Domain	Oxysterol-bd	OSBPL2 OSBPL1A	1.05e-03	12	76	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL2 OSBPL1A	1.05e-03	12	76	2	IPR018494
Domain	Oxysterol_BP	OSBPL2 OSBPL1A	1.05e-03	12	76	2	PF01237
Domain	OSBP	OSBPL2 OSBPL1A	1.05e-03	12	76	2	PS01013
Domain	AA_permease_2	SLC7A9 SLC7A8	1.24e-03	13	76	2	PF13520
Domain	AA/rel_permease1	SLC7A9 SLC7A8	1.24e-03	13	76	2	IPR002293
Domain	Channel_four-helix_dom	CACNA1D CACNA1F TPCN1	1.62e-03	57	76	3	IPR027359
Domain	-	CACNA1D CACNA1F TPCN1	1.62e-03	57	76	3	1.20.120.350
Domain	Frizzled/SFRP	FZD1 FZD2	1.89e-03	16	76	2	IPR015526
Domain	Sulfatase	ARSH PIGG	2.40e-03	18	76	2	PF00884
Domain	Sulfatase_N	ARSH PIGG	2.40e-03	18	76	2	IPR000917
Domain	FRI	FZD1 FZD2	2.96e-03	20	76	2	SM00063
Domain	-	FZD1 FZD2	3.26e-03	21	76	2	1.10.2000.10
Domain	AA-permease/SLC12A_dom	SLC7A9 SLC7A8	3.58e-03	22	76	2	IPR004841
Domain	AA_permease	SLC7A9 SLC7A8	3.58e-03	22	76	2	PF00324
Domain	zf-DHHC	ZDHHC17 ZDHHC11	3.91e-03	23	76	2	PF01529
Domain	Frizzled_dom	FZD1 FZD2	4.26e-03	24	76	2	IPR020067
Domain	FZ	FZD1 FZD2	4.26e-03	24	76	2	PS50038
Domain	Fz	FZD1 FZD2	4.26e-03	24	76	2	PF01392
Domain	DHHC	ZDHHC17 ZDHHC11	4.61e-03	25	76	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC17 ZDHHC11	4.61e-03	25	76	2	IPR001594
Domain	FHA	KIF1B SLMAP	5.77e-03	28	76	2	SM00240
Domain	FHA_DOMAIN	KIF1B SLMAP	7.04e-03	31	76	2	PS50006
Domain	FHA	KIF1B SLMAP	7.04e-03	31	76	2	PF00498
Domain	Alkaline_phosphatase_core	ARSH PIGG	7.04e-03	31	76	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSH PIGG	7.04e-03	31	76	2	IPR017849
Domain	-	ARSH PIGG	7.04e-03	31	76	2	3.40.720.10
Pubmed	Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.	OSBPL2 OSBPL1A	4.97e-06	2	78	2	11279184
Pubmed	MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis.	TET2 UHRF2	4.97e-06	2	78	2	34826027
Pubmed	Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.	CACNA1D CACNA1F	4.97e-06	2	78	2	25966695
Pubmed	Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.	FZD1 FZD2	4.97e-06	2	78	2	20189955
Pubmed	Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport.	TMEM87B TMEM87A	4.97e-06	2	78	2	26157166
Pubmed	C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.	CACNA1D CACNA1F	4.97e-06	2	78	2	16921373
Pubmed	Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.	FZD1 FZD2	1.49e-05	3	78	2	9813155
Pubmed	Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.	FZD1 FZD2	1.49e-05	3	78	2	27680706
Pubmed	Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.	PURA WRN	1.49e-05	3	78	2	12034829
Pubmed	Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.	ABL1 WRN	1.49e-05	3	78	2	12944467
Pubmed	Identification of the recognition sequence and target proteins for DJ-1 protease.	ABL1 KIF1B	1.49e-05	3	78	2	23831022
Pubmed	Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.	CACNA1D CACNA1F	1.49e-05	3	78	2	26024096
Pubmed	A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9.	ABL1 NUP98	2.97e-05	4	78	2	12032333
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1D CACNA1F	2.97e-05	4	78	2	20937870
Pubmed	Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.	FZD1 FZD2	2.97e-05	4	78	2	18929644
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC7A9 SLC7A8 SLC43A2	4.66e-05	31	78	3	18195088
Pubmed	Identification of LAT4, a novel amino acid transporter with system L activity.	SLC7A8 SLC43A2	4.94e-05	5	78	2	15659399
Pubmed	Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E.	CCNA1 FBXW7	4.94e-05	5	78	2	19423708
Pubmed	Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.	BMX ABL1	4.94e-05	5	78	2	12573241
Pubmed	Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.	TMEM87B TMEM87A	4.94e-05	5	78	2	36373655
Pubmed	Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.	TNKS2 GSK3A	7.40e-05	6	78	2	19759537
Pubmed	Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.	OSBPL2 OSBPL1A	7.40e-05	6	78	2	10588946
Pubmed	Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.	GSK3A FBXW7	7.40e-05	6	78	2	21220517
Pubmed	FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways.	FZD1 FZD2	7.40e-05	6	78	2	36867021
Pubmed	Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.	GSK3A FBXW7	7.40e-05	6	78	2	25897075
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1D CACNA1F RYR3	8.65e-05	38	78	3	30786075
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1D CACNA1F	1.04e-04	7	78	2	12900400
Pubmed	Transport of Iodothyronines by Human L-Type Amino Acid Transporters.	SLC7A8 SLC43A2	1.04e-04	7	78	2	26305885
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RALGDS CLPTM1L SMG8 MID1 GIGYF1 ZDHHC17 ZBED1 XAB2	1.06e-04	650	78	8	38777146
Pubmed	Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.	CCNA1 FBXW7	1.38e-04	8	78	2	12628165
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1D CACNA1F	1.38e-04	8	78	2	28330839
Pubmed	Protein binding and signaling properties of RIN1 suggest a unique effector function.	RALGDS ABL1	1.38e-04	8	78	2	9144171
Pubmed	The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.	OSBPL2 OSBPL1A	1.38e-04	8	78	2	17428193
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	FZD1 FZD2	1.38e-04	8	78	2	19388021
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	RYR3 TPCN1	1.38e-04	8	78	2	30563862
Pubmed	Metabolic activation-related CD147-CD98 complex.	SLC7A9 SLC7A8	1.77e-04	9	78	2	15901826
Pubmed	Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.	FZD1 FZD2	1.77e-04	9	78	2	23095888
Pubmed	FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation.	GSK3A FBXW7	1.77e-04	9	78	2	31843895
Pubmed	Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.	FZD1 FZD2	1.77e-04	9	78	2	12067714
Pubmed	TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8.	RALGDS TNFSF12	1.77e-04	9	78	2	21525013
Pubmed	Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.	GSK3A FBXW7	1.77e-04	9	78	2	26912724
Pubmed	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.	FZD1 FZD2	1.77e-04	9	78	2	9707618
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD1 FZD2	2.21e-04	10	78	2	15245425
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD1 FZD2	2.21e-04	10	78	2	17532316
Pubmed	CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.	TET2 ABL1 FBXW7	2.34e-04	53	78	3	24357321
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD1 FZD2	2.70e-04	11	78	2	24860427
Pubmed	The OSBP-related protein family in humans.	OSBPL2 OSBPL1A	2.70e-04	11	78	2	11483621
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD1 FZD2	2.70e-04	11	78	2	30978219
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD1 FZD2	2.70e-04	11	78	2	17582687
Pubmed	Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.	FZD1 FZD2	2.70e-04	11	78	2	25294940
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1D CACNA1F	2.70e-04	11	78	2	18809727
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD1 FZD2	2.70e-04	11	78	2	17576136
Pubmed	A family of 12 human genes containing oxysterol-binding domains.	OSBPL2 OSBPL1A	3.23e-04	12	78	2	11735225
Pubmed	Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network.	DNAJB13 RTRAF	3.23e-04	12	78	2	21994455
Pubmed	Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2.	PURA CCNA1	3.23e-04	12	78	2	15707957
Pubmed	An oxysterol-binding protein family identified in the mouse.	OSBPL2 OSBPL1A	3.23e-04	12	78	2	12215260
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	FZD1 FZD2	3.81e-04	13	78	2	21246654
Pubmed	Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.	RPGRIP1L SLC35F4	4.44e-04	14	78	2	21254220
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1D CACNA1F	5.12e-04	15	78	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1D CACNA1F	5.12e-04	15	78	2	24453333
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 RTRAF KIF1B OSBPL1A GATM PJA1 TNKS2 GSK3A XAB2 RYR3	5.88e-04	1285	78	10	35914814
Pubmed	Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.	GHSR KIF1B ZDHHC11 TPCN1	6.06e-04	171	78	4	28700664
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD1 FZD2	6.61e-04	17	78	2	28733458
Pubmed	Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.	ABL1 MIF4GD ZBED1 FBXW7	6.75e-04	176	78	4	27229929
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TET2 BMX ABL1 KIF1B NCOA7 GIGYF1 GSK3A ITPKB	6.95e-04	861	78	8	36931259
Pubmed	Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.	CACNA1D KIF1B	7.42e-04	18	78	2	33087486
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	KIF1B WRN	8.28e-04	19	78	2	14578343
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD1 FZD2	8.28e-04	19	78	2	21623369
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	KCNH7 DHRS7C MID1 UHRF2 FBXW7	9.06e-04	331	78	5	19490893
Pubmed	Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.	GSK3A FBXW7	9.19e-04	20	78	2	24912190
Pubmed	Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.	ZDHHC17 ZDHHC11	9.19e-04	20	78	2	16647879
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	CACNA1D KCNH7 KIF1B	9.39e-04	85	78	3	23055939
Pubmed	TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.	PURA GSK3A	1.01e-03	21	78	2	20194497
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD1 FZD2	1.11e-03	22	78	2	17064353
Pubmed	Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.	SLMAP FBXW7	1.22e-03	23	78	2	31748650
Pubmed	ATP-citrate lyase deficiency in the mouse.	FZD1 ELOVL6	1.22e-03	23	78	2	14662765
Pubmed	Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.	FZD1 FZD2	1.33e-03	24	78	2	35110543
Pubmed	Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.	ABL1 TNFSF12	1.33e-03	24	78	2	27709293
Pubmed	Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors.	FZD1 FZD2	1.44e-03	25	78	2	25805134
Pubmed	Substrate specificities and identification of putative substrates of ATM kinase family members.	ABL1 WRN	1.44e-03	25	78	2	10608806
Pubmed	The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling.	FZD1 FZD2	1.44e-03	25	78	2	15809042
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD1 FZD2	1.44e-03	25	78	2	12812787
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	RPGRIP1L L3MBTL2 SLC5A7	1.63e-03	103	78	3	29539633
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	KIF1B XAB2	1.68e-03	27	78	2	19026994
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	FZD1 FZD2	1.81e-03	28	78	2	20940229
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ERICH1 RPGRIP1L OSBPL2 KIF1B WRN NUP98 PJA1	1.81e-03	777	78	7	35844135
Pubmed	Genomic analysis of mouse retinal development.	FZD1 RALGDS ABL1 RTRAF NUP98 TNKS2 FZD2 XAB2	1.87e-03	1006	78	8	15226823
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD1 FZD2	1.94e-03	29	78	2	18364260
Pubmed	Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.	DNAJB13 CLPTM1L	1.94e-03	29	78	2	12652657
Pubmed	FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A.	RTRAF FBXW7	2.21e-03	31	78	2	36159747
Cytoband	Xp22.33	ARSH ZBED1	8.33e-04	25	78	2	Xp22.33
Cytoband	Ensembl 112 genes in cytogenetic band chrXp22	ARSH BMX MID1 ZBED1	8.93e-04	250	78	4	chrXp22
Cytoband	5p15.33	CLPTM1L ZDHHC11	1.37e-03	32	78	2	5p15.33
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD2	4.56e-04	11	53	2	286
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL2 OSBPL1A	5.46e-04	12	53	2	670
GeneFamily	Solute carriers	SLC7A9 SLC7A8 SLC43A2 SLC35C2 SLC5A7 SLC35F4	1.01e-03	395	53	6	752
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC17 ZDHHC11	2.23e-03	24	53	2	76
GeneFamily	Calcium voltage-gated channel subunits	CACNA1D CACNA1F	2.62e-03	26	53	2	253
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 KCNH7 MINDY4B CCNA1 SORCS3 ITPKB	1.23e-07	132	78	6	295980f70645ee2934145e9959c01f999044da3e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 KCNH7 MINDY4B CCNA1 SORCS3 ITPKB	1.89e-07	142	78	6	5b6b0c611c83b23ef7289854a515b78f6cf84500
Drug	CAS 298-57-7	CACNA1D CACNA1F TNFSF12 RYR3 TPCN1	4.56e-06	73	76	5	CID000002761
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1D CACNA1F	3.71e-05	4	74	2	DOID:0060173 (implicated_via_orthology)
Disease	Large cell carcinoma of lung	TRPM6 BMX ABL1	7.13e-05	32	74	3	C0345958
Disease	attention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder	SORCS3 PJA1 ITIH3	2.89e-04	51	74	3	EFO_0003756, EFO_0003888, MONDO_0002009, MONDO_0004985, MONDO_0005090
Disease	nasopharynx carcinoma (is_implicated_in)	TET2 CLPTM1L	6.38e-04	15	74	2	DOID:9261 (is_implicated_in)
Disease	alkaline phosphatase measurement	TET2 RALGDS B4GALNT4 MGAT5 ARHGAP10 TNKS2 ELOVL6 ITIH3 ITPKB	9.70e-04	1015	74	9	EFO_0004533
Disease	hepatocellular carcinoma (is_implicated_in)	TET2 CLPTM1L KIF1B RYR3	1.13e-03	181	74	4	DOID:684 (is_implicated_in)
Disease	serum homoarginine measurement	GATM UHRF2	1.14e-03	20	74	2	EFO_0005421
Disease	testosterone measurement	TRPM6 GALNT15 GHSR TET2 CACNA1D MGAT5 GTF3C2 TNFSF12 ARHGAP10 TNKS2	1.27e-03	1275	74	10	EFO_0004908
Disease	Kidney Diseases	SLC7A9 RPGRIP1L GATM	1.43e-03	88	74	3	C0022658
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	CACNA1D RYR3	1.65e-03	24	74	2	EFO_0006821, EFO_0006826
Disease	Pigmented Basal Cell Carcinoma	CLPTM1L FBXW7	2.25e-03	28	74	2	C1368275
Disease	oral squamous cell carcinoma (is_implicated_in)	CLPTM1L ABL1	2.25e-03	28	74	2	DOID:0050866 (is_implicated_in)
Disease	Carcinoma, Basal Cell	CLPTM1L FBXW7	2.41e-03	29	74	2	C4721806

Protein segments in the cluster

Peptide	Gene	Start	Entry
TEVHFYGKTIPWFVS	ARMT1	276	Q9H993
SAFFSYWITHILPEK	ERICH1	426	Q86X53
CATVWKAHYVTPKFY	ARSH	441	Q5FYA8
GWAVTVYDKPASFFK	ALG1L2	6	C9J202
VKWSAPEVFHYFKYS	BMX	576	P51813
FVSKHFTVEYWGKDG	ADAMTS6	106	Q9UKP5
WPRKFDVAGTAFHYK	ADAMTS6	776	Q9UKP5
LPKHIWFAYHFFAIT	AGBL1	1081	Q96MI9
GVYWQHKPKCFSDFI	SLC7A8	466	Q9UHI5
EKRPAPFGSSWVKHY	ARHGAP10	276	A1A4S6
IIAFKPKHYFTDAWN	CACNA1F	1241	O60840
YRPETGSWVFKVSHF	NUP98	866	P52948
GSWVFKVSHFSKYGL	NUP98	871	P52948
ALPLSHGAARKWFYK	GIGYF1	466	O75420
PAGTIHVILKWKFAY	RPGRIP1L	906	Q68CZ1
LAQFKKTLGPSWVHY	MGAT5	356	Q09328
KDYFHRGAKWTTAPK	GATM	201	P50440
KVLGTHKGWFLYTLG	TRMU	251	O75648
WGKFLKDHSYKAAPV	L3MBTL2	181	Q969R5
NKFTILHYSPFKAVW	KCNH7	396	Q9NS40
AKIAIHYFKGWFLID	KCNH7	486	Q9NS40
YDRFHWFKLVGSSPI	KIF1B	881	O60333
DYSVKIKFSWLGFDH	SLC43A2	241	Q8N370
DTHKSLYFKPTWVGC	CFAP65	881	Q6ZU64
AETWLGSFKETFYKH	GALNT15	441	Q8N3T1
VYSPRTQWIHFFKGD	MMP19	341	Q99542
WKKAYFRFHDPSSEL	MINDY4B	121	A8MYZ0
YFHLAAWAVPAVKTI	FZD2	371	Q14332
WFKFPGTSSKIEHFI	LRRC8E	136	Q6NSJ5
DFIFHGSIYPKLKFW	OSBPL1A	666	Q9BXW6
YFHLAAWAVPAIKTI	FZD1	446	Q9UP38
GPVSKFWAYAFVLSK	ELOVL6	106	Q9H5J4
DGKPRYDTFWKHFIF	GDE1	236	Q9NZC3
YTEFKFPQIKAHPWT	GSK3A	351	P49840
WLPFHVGRYLFSKSF	GHSR	276	Q92847
HYKFGWAQKISKPIT	SLC7A9	456	P82251
KHFWPETLAAFTGYS	CCNA1	401	P78396
VIKPGFIHSPWKSAY	FBXW7	341	Q969H0
DTYTAHAGAKFPIKW	ABL1	391	P00519
LFKKVVPYHCLGSIW	RALGDS	401	Q12967
WTTGYVFHGKPEKVF	DNAJB13	86	P59910
IWKFFFRKLTYGVHP	DHRS7C	241	A6NNS2
YSTLVFLPSFFHWGK	GPR21	156	Q99679
VIAFKPKGYFSDAWN	CACNA1D	1256	Q01668
FRAAGWKTTPAAHKY	MIF4GD	201	A9UHW6
WSLVKLGPAKSYNFH	SMG8	766	Q8ND04
IHSSDWPKFFEKYLR	RTRAF	51	Q9Y224
GFTAVHAKYQKPWLG	SLC5A7	216	Q9GZV3
YPSFHSFILIWGNKT	TAS2R20	271	P59543
TGKPHTLWVAFAKFY	XAB2	391	Q9HCS7
YTFSPHFKVFKWSGE	NCOA7	866	Q8NI08
HSWDKYGFTSVPLFV	SORCS3	641	Q9UPU3
VWKKHPVHRDFLGFY	ITIH3	781	Q06033
KKYPWIQLAGHAGSF	ITPKB	666	P27987
KMYFGHSSFKPVQWK	WRN	541	Q14191
PVILYFTKVEHWSSF	SLC35F4	381	A4IF30
FHGSIYPKLKFWGKS	OSBPL2	196	Q9H1P3
KWKNYGLRIFGFIHP	B4GALNT4	161	Q76KP1
IYPDFSTWIKLTFVH	CCDC54	241	Q8NEL0
VAHLPWKAFTYKAFN	CLPTM1L	461	Q96KA5
VKYWPEISSSHGFLV	UHRF2	591	Q96PU4
WFTVSKFSHTGVEPY	TRPM6	1626	Q9BX84
KFSTKVPTFYHAWVQ	TAS1R1	661	Q7RTX1
LFWGIFDSLSHKKYD	RYR3	2541	Q15413
ALVWFDHKTGKFYLQ	SLMAP	56	Q14BN4
TWYAIGLAYKSAPKH	MID1	551	O15344
ITFYNKWLTKSFHFP	SLC35C2	31	Q9NQQ7
WKFTPLHEAAAKGKY	TNKS2	591	Q9H2K2
TFGIFIPFLPHAWKY	ZDHHC11	56	Q9H8X9
VALFYNFGKSWKSDP	ZDHHC17	396	Q8IUH5
KGGNFFSKHVPWSYL	TPCN1	466	Q9ULQ1
CSGPVKFTIVWHLKY	TMEM87B	81	Q96K49
WPKVKVVFVDPSFHY	ZSWIM3	276	Q96MP5
FKAYFTAPRKGTVWS	GTF3C2	696	Q8WUA4
WAHLKAAPFLTYFGL	TNFSF12	231	O43508
VAHPRAKSKVWKYFG	ZBED1	16	O96006
YGDETWVKLFPKHFV	PIGG	161	Q5H8A4
WVKLFPKHFVEYDGT	PIGG	166	Q5H8A4
DTKWHSFKSYYGIPC	TET2	51	Q6N021
YFHKPCVSIWLQKSG	PJA1	616	Q8NG27
SITVPYKVWAKFGHT	PURA	256	Q00577
KWHIPIPSGKNYFSF	TMEM87A	41	Q8NBN3