Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentproteasome activator complex

PSME1 PSME2

1.36e-053452GO:0008537
GeneOntologyCellularComponentproteasome complex

USP25 PSME1 PSME2

4.06e-0467453GO:0000502
Domain-

PSME1 PSME2

1.70e-0534521.20.5.120
DomainPA28_alpha

PSME1 PSME2

1.70e-053452PF02251
DomainPA28_beta

PSME1 PSME2

1.70e-053452PF02252
DomainProteasome_activ_pa28_C

PSME1 PSME2

1.70e-053452IPR003186
DomainProteasome_activ_pa28_N

PSME1 PSME2

1.70e-053452IPR003185
DomainELL

ELL3 ELL

1.70e-053452PF10390
Domain-

PSME1 PSME2

1.70e-0534521.20.120.180
DomainELL_N

ELL3 ELL

1.70e-053452IPR019464
DomainProteasome_activ_pa28

PSME1 PSME2

3.40e-054452IPR009077
DomainOccludin_ELL

ELL3 ELL

8.46e-056452IPR010844
DomainELL/occludin

ELL3 ELL

8.46e-056452IPR031176
DomainOccludin_ELL

ELL3 ELL

8.46e-056452PF07303
DomainTPR_2

GPSM1 KLC3

6.46e-0350452PF07719
DomainTPR_2

GPSM1 KLC3

6.46e-0350452IPR013105
PathwayREACTOME_S_PHASE

UBE2S MCM4 AKT2 PSME1 PSME2

3.71e-05146375MM15378
PathwayREACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX

UBE2S MCM4 PSME1 PSME2

5.78e-0581374MM15360
PathwayREACTOME_S_PHASE

UBE2S MCM4 AKT2 PSME1 PSME2

6.28e-05163375M3158
PathwayREACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE

UBE2S MCM4 PSME1 PSME2

8.73e-0590374MM15371
PathwayREACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE

UBE2S MCM4 PSME1 PSME2

9.51e-0592374M27666
PathwayREACTOME_DNA_REPLICATION_PRE_INITIATION

UBE2S MCM4 PSME1 PSME2

1.17e-0497374MM15369
PathwayREACTOME_G1_S_TRANSITION

MCM4 AKT2 PSME1 PSME2

1.53e-04104374MM15376
PathwayREACTOME_SYNTHESIS_OF_DNA

UBE2S MCM4 PSME1 PSME2

2.74e-04121374M5224
PathwayREACTOME_KEAP1_NFE2L2_PATHWAY

AKT2 AMER1 PSME1 PSME2

3.10e-04125374M45021
PathwayREACTOME_DNA_REPLICATION

UBE2S MCM4 PSME1 PSME2

3.10e-04125374MM15380
PathwayREACTOME_CELL_CYCLE

UBE2S MCM4 AKT2 NCAPH2 PSME1 PSME2 CENPF SYNE2

3.59e-04694378M543
PathwayREACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION

MCM4 AKT2 PSME1 PSME2

3.60e-04130374MM15146
PathwayREACTOME_CELL_CYCLE_MITOTIC

UBE2S MCM4 AKT2 NCAPH2 PSME1 PSME2 CENPF

5.54e-04561377M5336
PathwayREACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION

MCM4 AKT2 PSME1 PSME2

6.04e-04149374M848
PathwayREACTOME_CELL_CYCLE_CHECKPOINTS

UBE2S MCM4 PSME1 PSME2 CENPF

6.67e-04271375MM15388
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

AKT2 AMER1 PSME1 PSME2

7.52e-04158374MM14791
PathwayREACTOME_DNA_REPLICATION_PRE_INITIATION

UBE2S MCM4 PSME1 PSME2

7.70e-04159374M27665
PathwayREACTOME_REGULATION_OF_PTEN_STABILITY_AND_ACTIVITY

AKT2 PSME1 PSME2

7.74e-0469373MM15540
PathwayREACTOME_ORC1_REMOVAL_FROM_CHROMATIN

MCM4 PSME1 PSME2

7.74e-0469373MM15366
PathwayREACTOME_REGULATION_OF_PTEN_STABILITY_AND_ACTIVITY

AKT2 PSME1 PSME2

7.74e-0469373M27815
PathwayREACTOME_CYCLIN_A_CDK2_ASSOCIATED_EVENTS_AT_S_PHASE_ENTRY

AKT2 PSME1 PSME2

8.07e-0470373MM15389
PathwayREACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6

UBE2S PSME1 PSME2

8.41e-0471373MM15370
PathwayREACTOME_ORC1_REMOVAL_FROM_CHROMATIN

MCM4 PSME1 PSME2

8.41e-0471373M4138
PathwayREACTOME_CELL_CYCLE

UBE2S MCM4 AKT2 NCAPH2 PSME1 PSME2 CENPF

8.50e-04603377MM14635
PathwayREACTOME_CELL_CYCLE_CHECKPOINTS

UBE2S MCM4 PSME1 PSME2 CENPF

9.19e-04291375M16647
PathwayREACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1

UBE2S PSME1 PSME2

9.49e-0474373MM14678
PathwayREACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1

UBE2S PSME1 PSME2

9.49e-0474373M1030
PathwayREACTOME_ACTIVATION_OF_APC_C_AND_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS

UBE2S PSME1 PSME2

1.07e-0377373MM14692
PathwayREACTOME_KEAP1_NFE2L2_PATHWAY

AKT2 PSME1 PSME2

1.07e-0377373MM15698
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

AMER1 PSME1 PSME2

1.15e-0379373MM14754
PathwayREACTOME_DNA_REPLICATION

UBE2S MCM4 PSME1 PSME2

1.41e-03187374M1017
PathwayREACTOME_CYCLIN_A_CDK2_ASSOCIATED_EVENTS_AT_S_PHASE_ENTRY

AKT2 PSME1 PSME2

1.42e-0385373M27674
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

AMER1 PSME1 PSME2

1.42e-0385373M27079
PathwayREACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS

UBE2S PSME1 PSME2

1.52e-0387373MM14677
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

UBE2S PSME1 PSME2 CENPF

1.52e-03191374M29614
PathwayREACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS

UBE2S PSME1 PSME2

1.57e-0388373M29582
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

UBE2S PSME1 PSME2 CENPF

1.58e-03193374MM14890
PathwayREACTOME_PTEN_REGULATION

AKT2 PSME1 PSME2

2.13e-0398373MM15348
PathwayREACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS

AKT2 AMER1 PSME1 PSME2

2.15e-03210374M41836
PathwayWP_GASTRIC_CANCER_NETWORK_1

MCM4 CENPF

2.43e-0328372M39347
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CEP350 AFDN CLINT1 MPHOSPH9 AMER1 TMCC3 KLC3 SYNE2 SEC16A

1.34e-0686145936931259
Pubmed

High yield bacterial expression and purification of active recombinant PA28alphabeta complex.

PSME1 PSME2

1.64e-06245219017543
Pubmed

In vivo characterization of the proteasome regulator PA28.

PSME1 PSME2

1.64e-0624528663520
Pubmed

Relative functions of the alpha and beta subunits of the proteasome activator, PA28.

PSME1 PSME2

1.64e-0624529346951
Pubmed

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.

PSME1 PSME2

1.64e-06245230400847
Pubmed

The role of the proteasome activator PA28 in MHC class I antigen processing.

PSME1 PSME2

1.64e-06245212200048
Pubmed

Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing.

PSME1 PSME2

1.64e-06245212119343
Pubmed

Allele-selective effect of PA28 in MHC class I antigen processing.

PSME1 PSME2

1.64e-06245218641301
Pubmed

Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome.

PSME1 PSME2

1.64e-0624527789512
Pubmed

Expression and subcellular localization of mouse 20S proteasome activator complex PA28.

PSME1 PSME2

1.64e-0624529287111
Pubmed

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α4β3 Complex.

PSME1 PSME2

1.64e-06245228867616
Pubmed

Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.

PSME1 PSME2

1.64e-06245211689430
Pubmed

Impaired immunoproteasome assembly and immune responses in PA28-/- mice.

PSME1 PSME2

1.64e-06245210591649
Pubmed

Organization of the genes encoding the human proteasome activators PA28alpha and beta.

PSME1 PSME2

4.91e-06345210199920
Pubmed

Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki.

PSME1 PSME2

4.91e-0634529162094
Pubmed

Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.

PSME1 PSME2

4.91e-06345222308036
Pubmed

Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma brucei.

PSME1 PSME2

4.91e-06345210567354
Pubmed

N-α-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28β.

PSME1 PSME2

4.91e-06345223624078
Pubmed

Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators.

PSME1 PSME2

4.91e-0634529325261
Pubmed

Antiangiogenic tumor therapy by DNA vaccine inducing aquaporin-1-specific CTL based on ubiquitin-proteasome system in mice.

PSME1 PSME2

4.91e-06345222802414
Pubmed

Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes.

PSME1 PSME2

4.91e-0634529620878
Pubmed

Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes.

PSME1 PSME2

4.91e-0634529590240
Pubmed

PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.

PSME1 PSME2

4.91e-06345228278207
Pubmed

The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells.

PSME1 PSME2

4.91e-06345216569681
Pubmed

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks.

PSME1 PSME2

4.91e-06345233262340
Pubmed

Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma.

MCM4 CENPF

4.91e-06345220398247
Pubmed

Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts.

PSME1 PSME2

4.91e-06345226944190
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

CEP350 POR AFDN CLINT1 MPHOSPH9 AMER1 SMC6 SEC16A

6.21e-0677745835844135
Pubmed

Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins.

PSME1 PSME2

9.81e-06445222564544
Pubmed

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus.

PSME1 PSME2

1.63e-05545215356141
Pubmed

The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus.

PSME1 PSME2

1.63e-05545211471063
Pubmed

Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii.

PSME1 PSME2

1.63e-05545231608052
Pubmed

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire.

PSME1 PSME2

1.63e-05545229067678
Pubmed

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.

PSME1 PSME2

1.63e-05545221360704
Pubmed

Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.

PSME1 PSME2

1.63e-05545223209186
Pubmed

[Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5].

AFDN ELL

1.63e-05545216086288
Pubmed

Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells.

PSME1 PSME2

1.63e-05545212519221
Pubmed

Why the structure but not the activity of the immunoproteasome subunit low molecular mass polypeptide 2 rescues antigen presentation.

PSME1 PSME2

2.45e-05645222772448
Pubmed

Antigen presentation by MHC class I and its regulation by interferon gamma.

PSME1 PSME2

2.45e-05645210047537
Pubmed

Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions.

PSME1 PSME2

2.45e-05645237347796
Pubmed

Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes.

PSME1 PSME2

2.45e-05645211345588
Pubmed

Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.

PSME1 PSME2

2.45e-05645215944286
Pubmed

Human immunodeficiency virus type 1 Gag p24 alters the composition of immunoproteasomes and affects antigen presentation.

PSME1 PSME2

2.45e-05645219403671
Pubmed

Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex.

PSME1 PSME2

2.45e-0564529344661
Pubmed

Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis.

PSME1 PSME2

3.42e-05745210799514
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

AFDN PSME1 CENPF SMC6 SEC16A

4.53e-0530445532235678
Pubmed

Pronounced up-regulation of the PA28alpha/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation.

PSME1 PSME2

7.32e-051045211745344
Pubmed

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses.

PSME1 SEC16A

8.94e-051145231114588
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CEP350 AFDN CLINT1 MPHOSPH9 AMER1 PSME1 ELL

1.05e-0485345728718761
Pubmed

The little elongation complex regulates small nuclear RNA transcription.

ELL3 ELL

1.07e-041245222195968
Pubmed

Defining the membrane proteome of NK cells.

CEP350 POR MCM4 CLINT1 NCAPH2 MPHOSPH9 PSME2 PSD4

1.13e-04116845819946888
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

CENPF HSPA4L SYNE2 SEC16A

1.24e-0419745420811636
Pubmed

PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes.

PSME1 PSME2

1.47e-04144529218537
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

SIX5 HSPA4L SYNE2 BRD9 SEC16A

1.60e-0439845535016035
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

MCM4 AFDN MRPL55 BRD9

1.73e-0421545435973513
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

MCM4 AFDN CLINT1 ELL SMC6 BRD9 SEC16A

2.09e-0495445736373674
Pubmed

Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit.

PSME1 PSME2

2.20e-04174529382924
Pubmed

Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action.

PSME1 PSME2 HSPA4L

2.35e-049245335530310
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

MCM4 AFDN CLINT1 NCAPH2 AMER1 KLC3 SMC6 SEC16A

2.61e-04132145827173435
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

MCM4 AFDN CLINT1 MPHOSPH9 HSPA4L SEC16A

2.89e-0470845639231216
Pubmed

Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.

MCM4 SYNE2 SEC16A

3.09e-0410145326949739
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

CEP350 MPHOSPH9 TMCC3 SYNE2

3.13e-0425145429778605
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

CEP350 POR CLINT1 MPHOSPH9 PSME1 SYNE2 SEC16A

3.71e-04104945727880917
Pubmed

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

CLINT1 SEC16A

3.72e-042245226950368
Pubmed

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

CLINT1 SEC16A

5.22e-042645224067654
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

CLINT1 SLC25A10 SEC16A

5.76e-0412545336030824
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

CEP350 POR CENPF LOX

5.97e-0429845432353859
Pubmed

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.

POR HSPA4L SYNE2 SLC25A10

6.04e-0429945437931956
Pubmed

Novel interactors and a role for supervillin in early cytokinesis.

MPHOSPH9 CENPF

6.06e-042845220309963
Pubmed

Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis.

RIMS2 SLC25A10

7.92e-043245217332066
Pubmed

RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

SIX5 AKT2

7.92e-043245220111592
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

CLINT1 AMER1 SLC25A10 SEC16A

7.97e-0432245439098523
Pubmed

Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.

SARDH PCYT1B

8.43e-043345234702858
Pubmed

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

CLINT1 HSPA4L SEC16A

9.40e-0414845335676246
Pubmed

Host PDZ-containing proteins targeted by SARS-CoV-2.

AFDN RIMS2

9.48e-043545233864728
Pubmed

Widespread macromolecular interaction perturbations in human genetic disorders.

FSD2 FUNDC1 NCAPH2 ZSCAN22 PSD4

9.64e-0459045525910212
Pubmed

Structure and functions of the 20S and 26S proteasomes.

PSME1 PSME2

1.06e-03374528811196
Pubmed

An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.

PSME1 PSME2

1.06e-03374529811770
Pubmed

Hypermutation of HIV-1 DNA in the absence of the Vif protein.

PSME1 PSME2

1.06e-033745212750511
Pubmed

Death by deamination: a novel host restriction system for HIV-1.

PSME1 PSME2

1.06e-033745212914693
Pubmed

Good to CU.

PSME1 PSME2

1.06e-033745212840737
Pubmed

Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions.

PSME1 PSME2

1.06e-033745212719574
Pubmed

Evidence for a newly discovered cellular anti-HIV-1 phenotype.

PSME1 PSME2

1.06e-03374529846577
Pubmed

DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.

PSME1 PSME2

1.06e-033745212830140
Pubmed

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.

PSME1 PSME2

1.12e-033845212808465
Pubmed

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.

PSME1 PSME2

1.12e-033845212808466
Pubmed

Virology. Weapons of mutational destruction.

PSME1 PSME2

1.12e-033845212920286
Pubmed

HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.

PSME1 PSME2

1.12e-033845214527406
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

CEP350 MPHOSPH9

1.12e-033845236674791
Pubmed

Degradation of HIV-1 integrase by the N-end rule pathway.

PSME1 PSME2

1.12e-033845210893419
Pubmed

The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.

PSME1 PSME2

1.12e-033845214557625
Pubmed

DNA deamination mediates innate immunity to retroviral infection.

PSME1 PSME2

1.12e-033845212809610
Pubmed

The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity.

PSME1 PSME2

1.12e-033845212970355
Pubmed

The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.

PSME1 PSME2

1.12e-033845214614829
Pubmed

HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation.

PSME1 PSME2

1.18e-033945214528301
Pubmed

The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.

PSME1 PSME2

1.24e-034045212419264
Pubmed

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

PSME1 PSME2

1.24e-034045212167863
Pubmed

The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.

PSME1 PSME2

1.24e-034045214528300
CytobandEnsembl 112 genes in cytogenetic band chr19q13

UBE2S SIX5 AKT2 ACP4 ZSCAN22 KLC3

1.04e-031192456chr19q13
Cytoband19q13.43

UBE2S ZSCAN22

3.33e-038745219q13.43
CytobandEnsembl 112 genes in cytogenetic band chr9q34

SARDH GPSM1 SEC16A

4.00e-03325453chr9q34
CytobandEnsembl 112 genes in cytogenetic band chr14q12

PSME1 PSME2

4.81e-03105452chr14q12
Cytoband9q34.3

GPSM1 SEC16A

4.90e-031064529q34.3
GeneFamilyAF4/FMR2 family|Super elongation complex

ELL3 ELL

9.51e-0593021280
GeneFamilyProteasome

PSME1 PSME2

2.30e-0343302690
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

GPSM1 KLC3

1.55e-02115302769
CoexpressionGAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_7DY_UP

UBE2S MCM4 GNA15 GNLY PSME1 PSME2

1.03e-05292456M41140
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_CYCLING_NK_CELL

UBE2S MCM4 NCAPH2 MPHOSPH9 CENPF MRPL55 SYNE2 SMC6

2.10e-05694458M45767
CoexpressionGSE40666_WT_VS_STAT1_KO_CD8_TCELL_WITH_IFNA_STIM_90MIN_DN

MCM4 CACNG4 HSPA4L MXD1 KLC3

2.35e-05200455M9215
CoexpressionPUJANA_BRCA2_PCC_NETWORK

UBE2S MCM4 GNA15 CLINT1 MPHOSPH9 CENPF

8.48e-05426456M9516
CoexpressionSHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6

UBE2S MCM4 MPHOSPH9 CENPF SMC6 SLC25A10

1.26e-04458456M8520
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_PROMONOCYTE_LIKE_CELL

UBE2S MCM4 NCAPH2 MPHOSPH9 CENPF

1.36e-04290455M45736
CoexpressionHE_LIM_SUN_FETAL_LUNG_C5_PRO_B_CELL

UBE2S MCM4 GNA15 NCAPH2 CENPF SYNE2

1.59e-04478456M45785
CoexpressionGSE3920_IFNB_VS_IFNG_TREATED_ENDOTHELIAL_CELL_DN

USP25 GNA15 CENPF PCYT1B

2.41e-04177454M6703
CoexpressionGSE15659_NAIVE_VS_PTPRC_NEG_CD4_TCELL_UP

FUNDC1 ACOT6 CENPF ALKBH7

3.35e-04193454M3536
CoexpressionGSE3982_MEMORY_CD4_TCELL_VS_TH1_UP

USP25 CEP350 MPHOSPH9 SYNE2

3.62e-04197454M5378
CoexpressionVAN_DEN_BIGGELAAR_PBMC_PREVNAR_9MO_INFANT_STIMULATED_VS_UNSTIMULATED_8MO_UP

MCM4 GNLY CENPF

3.67e-0481453M40892
CoexpressionGSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN

USP25 PSME1 PSME2 ZCCHC2

3.69e-04198454M8969
CoexpressionGSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_DN

SIX5 GNA15 PSME1 ELL3

3.76e-04199454M8113
CoexpressionGSE369_SOCS3_KO_VS_IFNG_KO_LIVER_DN

FSD2 AFDN ELL3 MXD1

3.76e-04199454M5983
CoexpressionGSE40277_EOS_AND_LEF1_TRANSDUCED_VS_GATA1_AND_SATB1_TRANSDUCED_CD4_TCELL_DN

UBE2S TMCC3 SYNE2 SLC25A10

3.76e-04199454M9170
CoexpressionGSE3039_CD4_TCELL_VS_B1_BCELL_UP

UBE2S MPHOSPH9 AMER1 SEC16A

3.84e-04200454M6466
CoexpressionGSE24634_TEFF_VS_TCONV_DAY7_IN_CULTURE_UP

MCM4 MPHOSPH9 CENPF SMC6

3.84e-04200454M4622
CoexpressionGSE25085_FETAL_LIVER_VS_ADULT_BM_SP4_THYMIC_IMPLANT_DN

UBE2S MCM4 MPHOSPH9 PCYT1B

3.84e-04200454M8069
CoexpressionGSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_DN

USP25 PSME1 PSME2 ZCCHC2

3.84e-04200454M7595
CoexpressionGSE28737_BCL6_HET_VS_BCL6_KO_MARGINAL_ZONE_BCELL_UP

USP25 ELL3 TMCC3 MXD1

3.84e-04200454M9348
CoexpressionGSE37533_PPARG1_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN

USP25 PSME1 PSME2 ZCCHC2

3.84e-04200454M8967
CoexpressionGSE27786_CD4_VS_CD8_TCELL_UP

CACNG4 CLINT1 ELL BRD9

3.84e-04200454M4819
CoexpressionGSE27786_NKTCELL_VS_NEUTROPHIL_DN

AKT2 CACNG4 KLC3 BRD9

3.84e-04200454M4869
CoexpressionGSE21063_WT_VS_NFATC1_KO_3H_ANTI_IGM_STIM_BCELL_DN

USP25 CLINT1 PSME1 PSME2

3.84e-04200454M8253
CoexpressionGSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_UP

CEP350 AMER1 ELL3 PSD4

3.84e-04200454M7841
CoexpressionGSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_DN

UBE2S AFDN SMC6 BRD9

3.84e-04200454M8576
CoexpressionGSE29164_DAY3_VS_DAY7_CD8_TCELL_TREATED_MELANOMA_UP

SIX5 ELL PCYT1B PSD4

3.84e-04200454M8488
CoexpressionGSE16450_CTRL_VS_IFNA_12H_STIM_MATURE_NEURON_CELL_LINE_DN

AKT2 PSME2 CENPF BRD9

3.84e-04200454M7412
CoexpressionGSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_TREG_UP

CEP350 FSD2 HSPA4L BRD9

3.84e-04200454M4313
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

USP25 CEP350 POR CACNG4 SARDH RIMS2 CENPF SYNE2 SMC6

6.38e-06654449Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000

USP25 CEP350 POR CACNG4 SARDH RIMS2 CENPF HSPA4L SYNE2 SMC6

2.55e-059834410Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

USP25 CEP350 CACNG4 RIMS2 CENPF SYNE2

5.59e-05328446Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500

USP25 CACNG4 SARDH RIMS2 CENPF HSPA4L SYNE2

6.35e-05493447Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500_k-means-cluster#5

CACNG4 SARDH RIMS2 CENPF SYNE2

1.14e-04232445Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500_K5
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GNA15 CACNG4 SARDH RIMS2 CENPF

1.54e-061954555812b1615676f3b77eb4769216b98b360c417c0d
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

CLINT1 LOX MXD1 SYNE2 SMC6

1.70e-0619945518a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellIIH-CD4-CD8_1|IIH / Condition, Cell_class and T cell subcluster

USP25 FSD2 AKT2 SARDH

1.39e-05145454296b6b0eea3233d76742ea35252b2f54d4c27ab6
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UBE2S MCM4 CENPF KLC3

2.72e-05172454ba36581ae339191a12a6d3ead39eaf69d78be10e
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UBE2S PSME2 CENPF LOX

3.25e-05180454ed4966765a6b25456f68185cf0648c4a3a21d7fe
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MCM4 AFDN CACNG4 CENPF

3.69e-0518645410565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

GNA15 HSPA4L MXD1 KLC3

3.93e-05189454533c302df467d13ab639232daf4f8cafb808260b
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP350 CLINT1 HSPA4L SYNE2

4.09e-0519145460c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP350 CLINT1 HSPA4L SYNE2

4.09e-0519145409db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP350 CLINT1 HSPA4L SYNE2

4.09e-05191454973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell3'_v3-blood-Lymphocytic_NK-Cycling_NK|blood / Manually curated celltypes from each tissue

MCM4 GNLY NCAPH2 CENPF

4.35e-05194454bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MCM4 GNLY CENPF SLC25A10

4.53e-05196454f70a2b227716a0df3c1aa6a414b822e63f209a43
ToppCellCV-Moderate-1|Moderate / Virus stimulation, Condition and Cluster

GNLY PSME1 PSME2 ZCCHC2

4.53e-05196454b50cfcd87c5b67806450cb8b3c6860ab97f6d3b1
ToppCellsevere-T/NK_proliferative|severe / disease stage, cell group and cell class

UBE2S MCM4 PSME2 CENPF

4.53e-0519645489f005216770dbb84378f5d1f20ca11b0ce40faa
ToppCell343B-Lymphocytic-NK_cells-NK_cell_C|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GNLY PSME1 PSME2 SYNE2

4.62e-05197454879974aff3f887648a00b4659b46d9897c9eb467
ToppCellsevere-T/NK_proliferative|World / disease stage, cell group and cell class

UBE2S MCM4 NCAPH2 CENPF

4.62e-051974546b7b068b103fd4f6ceda8e01f4dd39eefc3b3633
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

GNLY ZCCHC2 SYNE2 SEC16A

4.71e-0519845476d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

UBE2S PSME1 SARDH CENPF

4.71e-05198454beebbf637221021686e932c3d1bbf0f62cf95536
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MCM4 GNLY CENPF SYNE2

4.71e-0519845480b105a7c7d00ea3b5e586831fbb755bd84f9d1a
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CEP350 CENPF SYNE2 SEC16A

4.71e-0519845476d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MCM4 GNLY CENPF SYNE2

4.71e-05198454c73e906d2d12d6eba0e606958be16e63a2292cd0
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MCM4 GNLY CENPF SYNE2

4.80e-05199454e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCellSevere|World / Disease group and Cell class

UBE2S MCM4 GNA15 CENPF

4.80e-05199454b73ae402b258fcc17e6cd6d6045244eccfe38ef8
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

USP25 CEP350 SYNE2 SMC6

4.80e-05199454c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MCM4 GNLY CENPF SYNE2

4.80e-05199454fba48342066aab41a8bcb20db40a6df0158e1cbe
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MCM4 GNLY CENPF SYNE2

4.80e-05199454305a9ade5bbe8e981e7c641c9a5e0c9f8ef60470
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

UBE2S MPHOSPH9 CENPF SYNE2

4.80e-0519945498575fcce726589e93fbb4df1aab03e57cb56076
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

MCM4 GNLY CENPF SYNE2

4.80e-05199454101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

PSME1 PSME2 ZCCHC2 SYNE2

4.80e-05199454056a0538ca5e825ae6195b4c76c208708a014533
ToppCell356C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MCM4 NCAPH2 CENPF SLC25A10

4.89e-052004545d11a2c0021805e78d97dc1638bf73ca1faede66
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UBE2S MCM4 NCAPH2 CENPF

4.89e-0520045483cc5f7e812896d97950afbc6bdc10c4eb2f507a
ToppCell356C-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

MCM4 NCAPH2 CENPF SLC25A10

4.89e-0520045497e47eb69d1d4cab45256acca9589837eb7817e7
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UBE2S MCM4 CENPF SYNE2

4.89e-05200454dd5b753bb1333fa502b9d3a6d65a53a9882b2451
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Highly_activated_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MCM4 GNLY PSME2 CENPF

4.89e-05200454d92d3bc63a56a604d7b1d49e62d4304e5e4017f2
ToppCellVE|World / Condition, Cell_class and T cell subcluster

UBE2S PSME1 PSME2 SYNE2

4.89e-052004548ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GNLY PSME1 PSME2 SYNE2

4.89e-052004546c2543ff19a81c898f9e07d1fea97d16fa96e2bc
ToppCellParenchymal-10x5prime-Immune_Myeloid-Myeloid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPSM1 CENPF PCYT1B

2.25e-04117453f0c738b6b850733f9af68704172554177a1c1198
ToppCellParenchymal-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPSM1 CENPF PCYT1B

2.25e-04117453b5cb9d69ddd42331134f7e4bd51bd1c31030893c
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-AT1-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ACP4 ELL3 KLC3

2.92e-04128453082b3dc312b033c9b21cf73499009a1dc049ee2b
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GNA15 CENPF MXD1

3.72e-04139453505bf5a483fc2ba69377db9850c3b26ab2f416d1
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|367C / Donor, Lineage, Cell class and subclass (all cells)

GNLY SYNE2 PSD4

5.02e-04154453a39877cdf7b441b5c953f744ed30f1d5acf4ea19
ToppCellfacs-SCAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GNA15 MXD1 PSD4

5.12e-0415545393513bab53b40e9c3c91ab8e3316ea00a4f66cd2
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SIX5 GNLY TMCC3

5.21e-04156453c11ca6b1b5029c15aab91273cece70a487287839
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-2|TCGA-Colorectal / Sample_Type by Project: Shred V9

GNLY PSME1 HSPA4L

5.31e-0415745367641089eeb1a502e01fb6ea35c3d19e21a5789e
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GNLY ELL3 KLC3

5.41e-041584531bf692f1e85f677cd62805437b7a59cfaf3b0449
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1|E18.5-samps / Age Group, Lineage, Cell class and subclass

SIX5 MCM4 LOX

5.51e-04159453b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GNLY SYNE2 PSD4

5.51e-04159453bf8ff9251bcb64b2b9d6dd93461aec97659686ec
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GNA15 CLINT1 PSME1

5.51e-04159453a5fee9e7ee00c20a4ba30b0dfaf1189fb109a1af
ToppCellPND07-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSME1 PSME2 MXD1

5.61e-0416045301f22cdb2a2f73776b7f91746e95c1850df94235
ToppCellICU-NoSEP-Lymphocyte-T_NK-gdT|ICU-NoSEP / Disease, Lineage and Cell Type

SIX5 GNLY SYNE2

5.61e-041604532798c5bd971407f27dd4d3a4831d63d9c88003c3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFDN GNA15 ELL3

5.61e-04160453529034a1101d7772d82f86beb5c6fa9c9dd97067
ToppCellPND07-Immune-Immune_Myeloid-DC-maDC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSME1 PSME2 MXD1

5.61e-041604537db30647b596f0c419087e6fabb9b99dcd5bddd4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

UBE2S CENPF KLC3

5.72e-04161453a7e09cf2ca6cd70d40d08440fe9c5ab9befa1b79
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

UBE2S CENPF KLC3

5.72e-0416145308920a716f6ec62538e361211455a30ad726d7be
ToppCellhuman_hepatoblastoma-Tumor_cells-T7|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

GNLY ALKBH7 KLC3

5.82e-04162453c6ace47daf32495b25793d39b72382978349597d
ToppCellCOVID-19_Severe-multiplets|World / disease group, cell group and cell class

MCM4 GNLY CENPF

5.92e-041634536db4271c2d47a9c333964f36d2c32207115e52cd
ToppCell3'_v3-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|Lung / Manually curated celltypes from each tissue

MCM4 CENPF MXD1

5.92e-0416345347300dec94dc66e965bf71fafff0a9fd24fae968
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GNLY GPSM1 SYNE2

6.03e-04164453ed7277f8980f96f5b3e4eed025d46d0942e123d7
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GNA15 CLINT1 PSME1

6.03e-04164453662f74ad2656c0af158dbf9eb81d5bf70f54e529
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GNLY GPSM1 SYNE2

6.03e-04164453c4ad98106e8663caf7c1c15d30ec633d8bd8cf57
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POR MXD1 SLC25A10

6.14e-04165453ce79d217df88035457cd58f679e72dd98722ae22
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UBE2S MCM4 CENPF

6.25e-041664532642544070564debe2deb2938d2c33997bf5ef02
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic|TCGA-Mesothelium / Sample_Type by Project: Shred V9

UBE2S SARDH GPSM1

6.36e-041674539062577a4b7902c9a888d706589d1b05221c0fa8
ToppCellPND14-Immune-Immune_Myeloid-Dendritic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GNA15 MPHOSPH9 CENPF

6.47e-041684539b8a74abb83c64f0b5829dcb4275f722c82b45dc
ToppCellPND14-Immune-Immune_Myeloid-Dendritic-cDC1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GNA15 MPHOSPH9 CENPF

6.47e-041684534b152b8d0f4a66faf664dfacb7914b18d60ce64a
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FSD2 ELL3 SMC6

6.47e-04168453eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FSD2 ELL3 SMC6

6.47e-04168453063d0368d656962b335154c230bdcd9236e7c9ad
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FSD2 ELL3 SMC6

6.47e-04168453a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCellPND14-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GNA15 MPHOSPH9 CENPF

6.47e-04168453c3169ad8f4130ef18777ed86770bb722ffb5db85
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSME1 PSME2 MXD1

6.58e-04169453a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCellfacs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SARDH RIMS2 SLC25A10

6.58e-04169453922086f218135b734b7d370b871923e50141edce
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GNLY MPHOSPH9 ZSCAN22

6.58e-041694538caf7996796a2e2716e3855de855c903d6126bf2
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

USP25 CLINT1 CENPF

6.58e-041694534db49b7eaea34e6558ee73b01e76315e99cc880b
ToppCellfacs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SARDH RIMS2 SLC25A10

6.58e-04169453ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSME1 PSME2 MXD1

6.58e-04169453f914aa8899fa170a09da31e5fad86de897ea789b
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM4 CACNG4 LOX

6.58e-04169453335619507857383c3b0b507cdf05d786ed59e585
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FSD2 ZSCAN22 LOX

6.69e-04170453ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UBE2S CENPF LOX

6.69e-0417045321bfe070e63722672176052b386167ea4c3dc4e5
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

GNLY CENPF SYNE2

6.81e-04171453dfd4a15ab68ef5a9a1954b1b1540ae04017885a6
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POR TMCC3 MXD1

6.81e-041714535d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UBE2S ACOT6 CENPF

6.81e-04171453d6114db2292fbb27b39d090d51fd305a135b1ccf
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UBE2S ACOT6 CENPF

6.81e-0417145305014cf6746e6663e376fdd681f1b43a7081c603
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GNLY MPHOSPH9 SYNE2

6.81e-04171453adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFDN TMCC3 MXD1

6.92e-041724536ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCelldroplet-Marrow-BM_(NON-STC)-30m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBE2S CENPF SMC6

6.92e-0417245331c5710fd7ebb221e703545595f5ec0ee3a32bcf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GPSM1 LOX TMCC3

6.92e-041724536c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MCM4 CENPF KLC3

6.92e-041724536fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

UBE2S PSME2 CENPF

6.92e-041724537f3d0ef18f5df1ed80498d435b0378ca398c0b88
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GPSM1 LOX TMCC3

6.92e-04172453381ae1c3c07d0a424f43455ec571653b192a946a
ToppCelldroplet-Marrow-BM_(NON-STC)|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBE2S CENPF SMC6

6.92e-041724536004327045f03d832fdabe6cb2f8b1b1db57789a
ToppCellASK454-Epithelial-Transformed_epithelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CACNG4 ELL PCYT1B

6.92e-041724533986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCell10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK|bone_marrow / Manually curated celltypes from each tissue

MCM4 NCAPH2 CENPF

7.04e-041734538a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCellfacs-Spleen-nan-24m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFDN PSME1 PSME2

7.04e-04173453e07e126e9dac6f1160cb3191d2e8374f39155d0d
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MCM4 AMER1 CENPF

7.04e-0417345320889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CENPF ELL3 SYNE2

7.04e-04173453b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MCM4 AMER1 CENPF

7.04e-0417345346e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-4|TCGA-Adrenal / Sample_Type by Project: Shred V9

POR SIX5 AKT2

7.16e-0417445315e2b9f46404ff9575e149024b24cb17b50b02b5
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELL SYNE2 SLC25A10

7.16e-041744539d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELL SYNE2 SLC25A10

7.16e-0417445353cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GPSM1 LOX TMCC3

7.16e-04174453dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

CEP350 CLINT1 SYNE2

3.88e-0450313GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
ComputationalNeighborhood of CDC20

UBE2S MCM4 CENPF

5.43e-0456313GNF2_CDC20
ComputationalNeighborhood of CCNB2

UBE2S MCM4 CENPF

5.72e-0457313GNF2_CCNB2
DrugPF-00875133-00 [351322-64-0]; Down 200; 10uM; PC3; HT_HG-U133A

AFDN GNA15 CACNG4 NCAPH2 CENPF ELL

2.32e-061964565928_DN
Diseaseobsolete_red blood cell distribution width

AFDN NCAPH2 ZCCHC2 GPSM1 ELL MXD1 SYNE2 BRD9

4.59e-041347418EFO_0005192
Diseasemean reticulocyte volume

CEP350 MCM4 AFDN GNA15 CLINT1 NCAPH2

7.75e-04799416EFO_0010701
Diseasecolorectal cancer (is_marker_for)

AKT2 AMER1 LOX

1.36e-03157413DOID:9256 (is_marker_for)
Diseasecreatinine measurement

POR FSD2 AKT2 CENPF ELL PSD4

2.37e-03995416EFO_0004518
Diseasealcohol use disorder (implicated_via_orthology)

AKT2 BRD9 PSD4

2.52e-03195413DOID:1574 (implicated_via_orthology)
Diseaseecosanoids measurement

POR ACOT6

2.67e-0355412EFO_0020044
Diseasenucleotide measurement

SYNE2 SMC6

4.65e-0373412EFO_0010513

Protein segments in the cluster

PeptideGeneStartEntry
SALEYLHSRDVVYRD

AKT2

261

P31751
YYSRLEAERRRQHDE

AFDN

1656

P55196
DFETDYAEYRILHAR

ELL3

306

Q9HB65
AEYSEYRDLHARIER

ELL

531

P55199
YYDDRSDHERERHKE

BRD9

51

Q9H8M2
FRAHARYRADARDEL

ACOT6

46

Q3I5F7
REAHAREAYTREAYG

AMER1

591

Q5JTC6
REAYGREAYAREAHT

AMER1

601

Q5JTC6
YAHALDGLYRVAREE

SLC25A10

141

Q9UBX3
EAYDRRLAHHLVALY

MCM4

656

P33991
ADYLERREREAEHGY

MXD1

16

Q05195
AREHIYDLRSLENYH

CLINT1

101

Q14677
EDYLYREELAQFHRD

POR

571

P16435
LLQDYERAAEYHLRH

GPSM1

301

Q86YR5
ERYEALRHCRYVDEV

PCYT1B

131

Q9Y5K3
PEYYDLARAHLRDEE

GNLY

26

P22749
HARHIADLRAYYESE

MPHOSPH9

451

Q99550
DVERHYARALSIYEA

KLC3

351

Q6P597
DAGIRAYYERRREFH

GNA15

141

P30679
AYYERRREFHLLDSA

GNA15

146

P30679
YEDSDHLSYRDSNRR

RIMS2

316

Q9UQ26
RYHELLREATEAAEY

ACP4

161

Q9BZG2
EYYRLAETRGARSDH

CPZ

331

Q66K79
RCYQDLHAEYESLRD

CENPF

751

P49454
DYDHDSSEYLLRIVR

CACNG4

91

Q9UBN1
DSYEVLDLTEYARRH

FUNDC1

16

Q8IVP5
RELYRDLALHFADDI

CEP350

366

Q5VT06
ASTAYRADVRDYDHR

LOX

246

P28300
YGLRDSRSEHERQYL

POLR3E

211

Q9NVU0
DYRQLVHELDEAEYR

PSME1

196

Q06323
YRYERLEDQLHDLTD

TMCC3

331

Q9ULS5
LERYDTYRDILEHHL

SYNE2

1116

Q8WXH0
LREAYRYTHGRASEE

FSD2

146

A1L4K1
RELEEHRLRKEYLEY

PSD4

956

Q8NDX1
QDLYLRARYHEAERA

SIX5

161

Q8N196
DYRALVHERDEAAYG

PSME2

186

Q9UL46
RAHEDYAYRRLLADE

SARDH

531

Q9UL12
ELEPELRRRRYEYDH

ALKBH7

51

Q9BT30
YLAAYADHADSRRLR

NCAPH2

366

Q6IBW4
DLARKDYHYLRDSEA

ZCCHC2

136

Q9C0B9
EYDAYRREHSAFGDR

SEC16A

1296

O15027
YEQELSDDLHVERYR

MRPL55

106

Q7Z7F7
IEAYRNKDERYDHLD

HSPA4L

716

O95757
YRGHDEELISHYRRE

USP25

916

Q9UHP3
EFRNEIYDVRHRAAY

SMC6

566

Q96SB8
YEEYAARARLLTEIH

UBE2S

141

Q16763
EAARLRFRHFRYEEA

ZSCAN22

46

P10073