Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

PRAMEF10 FMOD ASPN LRRK2 LRRC40 TSHR NLRP9 NOD1 IGFALS LRRC1 TLR5 FSHR LRRTM2 LMOD1 LGR6 DMAC2L

2.24e-09321139163.80.10.10
DomainL_dom-like

PRAMEF10 FMOD ASPN LRRK2 LRRC40 TSHR NLRP9 NOD1 IGFALS LRRC1 TLR5 FSHR LRRTM2 LMOD1 LGR6 DMAC2L

3.06e-0932813916IPR032675
DomainLeu-rich_rpt

FMOD ASPN LRRK2 LRRC40 TSHR NLRP9 NOD1 IGFALS LRRC1 TLR5 FSHR LRRTM2 LGR6

1.21e-0727113913IPR001611
DomainLRR_1

FMOD ASPN LRRK2 LRRC40 TSHR IGFALS LRRC1 TLR5 FSHR LRRTM2 LGR6

7.53e-0721913911PF00560
DomainLRR_8

FMOD ASPN LRRK2 LRRC40 IGFALS LRRC1 TLR5 LRRTM2 LGR6

5.42e-061711399PF13855
DomainLRR_TYP

FMOD ASPN LRRK2 LRRC40 IGFALS LRRC1 TLR5 LRRTM2 LGR6

7.17e-061771399SM00369
DomainLeu-rich_rpt_typical-subtyp

FMOD ASPN LRRK2 LRRC40 IGFALS LRRC1 TLR5 LRRTM2 LGR6

7.17e-061771399IPR003591
DomainGphrmn_rcpt_fam

TSHR FSHR LGR6

7.94e-0661393IPR002131
Domaindsrm

ADAR DICER1 DHX30 DGCR8

1.30e-05201394PF00035
DomainDS_RBD

ADAR DICER1 DHX30 DGCR8

1.59e-05211394PS50137
DomainLRR

FMOD ASPN LRRK2 LRRC40 IGFALS LRRC1 TLR5 LRRTM2 LGR6

1.99e-052011399PS51450
DomainLRRNT

FMOD ASPN IGFALS FSHR LGR6

4.57e-05531395PF01462
DomainLRRNT

FMOD ASPN IGFALS FSHR LRRTM2 LGR6

9.15e-05981396IPR000372
DomainLRRNT

FMOD ASPN IGFALS FSHR LRRTM2 LGR6

9.15e-05981396SM00013
DomainDSRM

ADAR DICER1 DGCR8

3.58e-04191393SM00358
DomainFAST_2

TBRG4 FASTKD2

8.09e-0461392PF08368
DomainRAP

TBRG4 FASTKD2

8.09e-0461392SM00952
DomainPH_BEACH

LYST NBEAL2

8.09e-0461392PF14844
DomainRAP

TBRG4 FASTKD2

8.09e-0461392PF08373
DomainRAP

TBRG4 FASTKD2

8.09e-0461392PS51286
DomainFAST_1

TBRG4 FASTKD2

8.09e-0461392PF06743
DomainFAST_Leu-rich

TBRG4 FASTKD2

8.09e-0461392IPR010622
DomainFAST_2

TBRG4 FASTKD2

8.09e-0461392IPR013579
DomainRAP

TBRG4 FASTKD2

8.09e-0461392IPR013584
Domain-

ADAR DICER1 DGCR8

1.04e-032713933.30.160.20
DomaindsRBD_dom

ADAR DICER1 DGCR8

1.15e-03281393IPR014720
DomainPH-BEACH_dom

LYST NBEAL2

1.50e-0381392IPR023362
Domain-

LYST NBEAL2

1.50e-03813922.30.29.40
DomainPH_BEACH

LYST NBEAL2

1.50e-0381392PS51783
PathwayWP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS

DICER1 XPO5 DGCR8

8.60e-0661083M39578
PathwayWP_MIRNA_BIOGENESIS

DICER1 XPO5 DGCR8

8.60e-0661083M39416
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

BRIX1 TBRG4 IPO8 WDR46 LRRC40 APOB CHD4 FASTKD2 API5 SSRP1 RFC5 ADAR DICER1 DHX30 XPO5 PDCD11 SEC63 DEK RPL6 AQR SLC27A4

7.28e-0714251482130948266
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

BRIX1 TBRG4 RPS6KA3 WDR46 LRRC40 CHD4 FASTKD2 SSRP1 RFC5 ADAR DHX30 SLC25A32 TAMM41 XPO5 PDCD11 SEC63 MRPL24 DEK RPL6 AQR

8.76e-0713181482030463901
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCNX3 SZT2 CTC1 TMEM94 ARHGEF11 PLEKHG5 LYST DHX30 CCDC142 PLCD3 JUNB ARHGEF40 TULP4 NBEAL2 TTLL4 NPRL3 PDCD11 KIFC3

1.20e-0611051481835748872
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TBRG4 SZT2 DOLK FASTKD2 CACHD1 PLEKHG5 PREPL DICER1 NBEAL2 TTLL4 PDCD11 HPS5

3.04e-065291481214621295
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

CLN8 ZWILCH PRAMEF33 PRAMEF10 SLC7A13 CTC1 RPS6KA3 ST6GAL1 APOB DCX PACS1 PPP3CB TTLL4 SEC63 NMT1 PRAMEF11 FHIP2B

4.01e-0610841481711544199
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

BRIX1 IPO8 RBM12B CHD4 SSRP1 RFC5 ADAR DHX30 PDCD11 DGCR8 DEK MTCH1 RPL6 AQR

4.92e-067591481435915203
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF33 PRAMEF10 NLRP9 PRAMEF11

5.95e-0628148425089626
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

PRAMEF10 MCTS1 LRRK2 IFIT2 NLRP9 MSL3 ZFHX2 LMOD1 TAC3 TMEM35A LY75 STAG3 PRAMEF11

6.77e-066741481337196079
Pubmed

Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.

DICER1 XPO5 DGCR8

8.87e-0610148320721975
Pubmed

Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma.

PTEN DICER1

1.80e-052148227602775
Pubmed

MicroRNA activity is suppressed in mouse oocytes.

DICER1 DGCR8

1.80e-052148220116252
Pubmed

Inhibition of Estrogen-Related Receptor α Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis.

ESRRA PTEN

1.80e-052148233894178
Pubmed

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.

DICER1 DGCR8

1.80e-052148228104803
Pubmed

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα).

ESRRA PTEN

1.80e-052148223836899
Pubmed

Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer.

PTEN EPHA2

1.80e-052148235869144
Pubmed

Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.

DICER1 DGCR8

1.80e-052148238252873
Pubmed

Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1.

DICER1 XPO5

1.80e-052148220852728
Pubmed

Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.

DICER1 XPO5

1.80e-052148221297638
Pubmed

Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.

PTEN DEK

1.80e-052148233755722
Pubmed

Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.

TSHR FSHR

1.80e-052148225340405
Pubmed

Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.

PTEN DICER1

1.80e-052148221278735
Pubmed

Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility.

DICER1 DGCR8

1.80e-052148225244517
Pubmed

Influence of genetic polymorphisms in DICER and XPO5 genes on the risk of coronary artery disease and circulating levels of vascular miRNAs.

DICER1 XPO5

1.80e-052148231185329
Pubmed

A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.

DICER1 DGCR8

1.80e-052148221712401
Pubmed

Thyroid nodules with DICER1 mutation or PTEN alteration: A comparative cytologic, clinical, and molecular study of 117 FNA cases.

PTEN DICER1

1.80e-052148238558329
Pubmed

DGCR8-dependent microRNA biogenesis is essential for skin development.

DICER1 DGCR8

1.80e-052148219114655
Pubmed

Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.

DICER1 DGCR8

1.80e-052148225934699
Pubmed

A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes.

DICER1 DGCR8

1.80e-052148224209619
Pubmed

A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.

PTEN DICER1

1.80e-052148223851498
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

BRIX1 RBM12B WDR46 CHD4 SSRP1 ADAR DHX30 JUNB XPO5 PDCD11 DGCR8 SEC63 DEK RPL6 SLC27A4

2.26e-059891481536424410
Pubmed

A cohesin-RAD21 interactome.

AMPD3 APOB CHD4 API5 C3 DEK RPL6

3.24e-05208148722145905
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

BRIX1 TBRG4 RBM12B WDR46 FASTKD2 API5 SSRP1 ADAR DHX30 XPO5 PDCD11 DEK AQR

4.43e-058071481322681889
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

BRIX1 WDR46 CHD4 SSRP1 ADAR DHX30 PDCD11 C3 DGCR8 RPL6

4.49e-054831481036912080
Pubmed

Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions.

KIFC3 USP47

5.38e-053148225253721
Pubmed

A microRNA expression signature of osteoclastogenesis.

DICER1 DGCR8

5.38e-053148221273303
Pubmed

Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.

DICER1 XPO5

5.38e-053148231250375
Pubmed

Mast cells instruct keratinocytes to produce thymic stromal lymphopoietin: Relevance of the tryptase/protease-activated receptor 2 axis.

F2RL1 DICER1

5.38e-053148235240143
Pubmed

Loss of JUNB/AP-1 promotes invasive prostate cancer.

PTEN JUNB

5.38e-053148225526087
Pubmed

Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.

DICER1 XPO5

5.38e-053148226976605
Pubmed

Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.

APOB PTEN

5.38e-053148219026012
Pubmed

Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells.

MCTS1 MCTS2

5.38e-053148224063864
Pubmed

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.

TSHR FSHR

5.38e-053148211847099
Pubmed

High-grade serous ovarian cancer arises from fallopian tube in a mouse model.

PTEN DICER1

5.38e-053148222331912
Pubmed

RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.

ADAR XPO5

5.38e-053148219124606
Pubmed

Combined stimulation of Toll-like receptor 5 and NOD1 strongly potentiates activity of NF-κB, resulting in enhanced innate immune reactions and resistance to Salmonella enterica serovar Typhimurium infection.

NOD1 TLR5

5.38e-053148223897616
Pubmed

PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.

PTEN DICER1

5.38e-053148228620008
Pubmed

Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8.

DICER1 DGCR8

5.38e-053148232124011
Pubmed

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.

TSHR FSHR

5.38e-053148215889138
Pubmed

PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment.

PTEN TLR5

5.38e-053148223038756
Pubmed

Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis.

DICER1 DGCR8

5.38e-053148227173348
Pubmed

Dicer1 facilitates liver regeneration in a manner dependent on the inhibitory effect of miR-21 on Pten and Rhob expression.

PTEN DICER1

5.38e-053148231306658
Pubmed

Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells.

DICER1 DGCR8

5.38e-053148222925886
Pubmed

Reduction of Cav1.3 channels in dorsal hippocampus impairs the development of dentate gyrus newborn neurons and hippocampal-dependent memory tasks.

CACNA1D DCX

5.38e-053148228715454
Pubmed

Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer.

PTEN DICER1

5.38e-053148229860390
Pubmed

Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease.

DICER1 DGCR8

5.38e-053148223663110
Pubmed

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.

RPS6KA3 EPHA2

5.38e-053148226158630
Pubmed

Hypothalamic miR-103 protects from hyperphagic obesity in mice.

PTEN DICER1

5.38e-053148225100599
Pubmed

DGCR8 is essential for tumor progression following PTEN loss in the prostate.

PTEN DGCR8

5.38e-053148226206718
Pubmed

Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.

PTEN PARVA

5.38e-053148212960424
Pubmed

Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.

DICER1 DGCR8

5.38e-053148225439752
Pubmed

Targeting progesterone signaling prevents metastatic ovarian cancer.

PTEN DICER1

5.38e-053148233262282
Pubmed

Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.

TSHR FSHR

5.38e-05314828747461
Pubmed

The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.

DICER1 DGCR8

5.38e-053148230295958
Pubmed

Whole Reproductive System Non-Negative Matrix Factorization Mass Spectrometry Imaging of an Early-Stage Ovarian Cancer Mouse Model.

PTEN DICER1

5.38e-053148227159635
Pubmed

Biogenesis of mammalian microRNAs by a non-canonical processing pathway.

DICER1 DGCR8

5.38e-053148222270084
Pubmed

Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder.

DICER1 XPO5

5.38e-053148222766726
Pubmed

Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.

PTEN DICER1

5.38e-053148232843721
Pubmed

Genetic variants in miRNA machinery genes associated with clinicopathological characteristics and outcomes of gastric cancer patients.

DICER1 XPO5

5.38e-053148229683064
Pubmed

The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.

DICER1 XPO5

5.38e-053148234855193
Pubmed

Transcript Level of MicroRNA Processing Elements in Gastric Cancer.

DICER1 DGCR8

5.38e-053148230168106
Pubmed

Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation.

DCX DICER1

5.38e-053148224945770
Pubmed

Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

DICER1 XPO5 DGCR8

5.88e-0518148319047128
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF33 PRAMEF10 PRAMEF11

8.16e-0520148326694250
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

TMEM94 CACHD1 BLZF1 PACS1 TAMM41 EPHA2 WDR20 LRRC1 SEC63

8.54e-05421148936976175
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

MCTS1 WDR46 CHD4 SSRP1 ADAR XPO5 DEK

9.81e-05248148727926873
Pubmed

A case-by-case evolutionary analysis of four imprinted retrogenes.

MCTS1 MCTS2

1.07e-044148221166792
Pubmed

LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.

LRRK2 NOD1

1.07e-044148227830463
Pubmed

Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kappaB for Toll-like receptor- and NOD-dependent activation.

F2RL1 NOD1

1.07e-044148217452051
Pubmed

A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency.

PTEN DICER1

1.07e-044148227346348
Pubmed

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.

NOD1 TLR5

1.07e-044148216648853
Pubmed

Variant mapping and mutation discovery in inbred mice using next-generation sequencing.

ADAR CLCN1

1.07e-044148226552429
Pubmed

Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.

DICER1 DGCR8

1.07e-044148226748703
Pubmed

3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.

DICER1 XPO5

1.07e-044148226147304
Pubmed

Distinct requirements of microRNAs in NK cell activation, survival, and function.

DICER1 DGCR8

1.07e-044148220805417
Pubmed

In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

PTEN DICER1

1.07e-044148232497036
Pubmed

ADAR1 inhibits adipogenesis and obesity by interacting with Dicer to promote the maturation of miR-155-5P.

ADAR DICER1

1.07e-044148235067718
Pubmed

Bacteria reduce flagellin synthesis to evade microglia-astrocyte-driven immunity in the brain.

TLR5 C3

1.07e-044148235793624
Pubmed

Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro.

ESRRA PTEN

1.07e-044148214525951
Pubmed

Selective amplification and cloning of four new members of the G protein-coupled receptor family.

HTR1D TSHR

1.07e-04414822541503
Pubmed

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

PTEN DGCR8

1.07e-044148223812098
Pubmed

Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.

DICER1 XPO5

1.07e-044148232770606
Pubmed

The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice.

PTEN DICER1

1.07e-044148225815421
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF33 PRAMEF10 PRAMEF11

1.10e-0422148331729367
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DICER1 PLCD3 PACS1 SLC25A32 ARHGEF40 AP5B1 HPS5 NMT1 RPL6 AQR SLC27A4

1.13e-046501481138777146
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

PCNX3 CHD4 SSRP1 ADAR MRPL24 RPL6 AQR

1.28e-04259148730404004
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

BRIX1 RBM12B WDR46 LRRC40 CHD4 SSRP1 RFC5 ADAR DICER1 DHX30 PDCD11 DEK RPL6 AQR

1.28e-0410241481424711643
Pubmed

Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.

DICER1 XPO5 DGCR8

1.43e-0424148320732906
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF33 PRAMEF10 PRAMEF11

1.62e-0425148337451217
Pubmed

Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.

DICER1 XPO5 DGCR8

1.62e-0425148319138993
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

CTC1 RFC5 ADAR DICER1 DHX30 PACS1 PPP3CB DGCR8 RPL6

1.72e-04462148931138677
Cytoband11p15.3

ZBED5 PARVA USP47

4.18e-0521148311p15.3
GeneFamilyGlycoprotein hormone receptors

TSHR FSHR

8.87e-053992199
ToppCellNS-critical-d_0-4-Myeloid-Neutrophil|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LRRK2 CARD16 PTEN IFIT2 LYST JUNB MCTP2

3.55e-0619214773db74359c30172a51177e00eac1f48f483e15578
ToppCellSepsis-URO|Sepsis / Disease, condition lineage and cell class

PIK3AP1 ESRRA PTEN NBEAL2 NMT1 MCTP2 ALOX15B

4.50e-0619914778e6dac82d1d0e759cd567f9c95b70cb4801d7caf
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TCERG1L RXFP3 IFIT2 C12orf50 MCTP2 ALOX15B

8.45e-06144147671107275767a0728541a3695715c44874b3e5efc
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MNS1 ST6GAL1 PKD1L3 TXNDC11 PLCD3 LMOD1

1.77e-051641476b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MNS1 ST6GAL1 PKD1L3 TXNDC11 PLCD3 LMOD1

1.77e-051641476a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCellCV-Mild-7|CV / Virus stimulation, Condition and Cluster

LCORL ZBED5 ZDHHC23 COG1 SIMC1 FITM2

2.17e-05170147625ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FMOD TMEM30CP IL1RAPL1 LRRC1 TLR5 C3

2.39e-051731476ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCellCV-Mild-7|Mild / Virus stimulation, Condition and Cluster

ZBED5 ZDHHC23 COG1 AP5B1 SIMC1 FITM2

2.39e-051731476c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FMOD TMEM30CP IL1RAPL1 LRRC1 TLR5 C3

2.39e-0517314763725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D TMEM94 ADAR SLC9A7 ZFHX2 FITM2

2.47e-051741476f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MNS1 TMEM94 ST6GAL1 SSRP1 NOD1 USP47

2.72e-05177147695760841b3f085d38c4926b258a33563d93a2016
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC2A8 SZT2 STOX1 PTEN PACS1 NPRL3

3.70e-0518714763699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC2A8 SZT2 STOX1 PTEN PACS1 NPRL3

3.70e-051871476033ba52c0c2f9978784947098fa697368ae44834
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

3.70e-05187147675bc05a0ba2727fecc236903ace792a28f3d3c9a
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

3.70e-051871476a0d59bf1043ff5a1e8110b39ecc2d3932675edd4
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STOX1 BLZF1 ZDHHC23 TTLL4 TLR5 FHIP2B

3.70e-051871476f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

3.81e-051881476aa46073e2940dc1d2020b2e259bf0fc06cb990ee
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

3.81e-05188147604814b78da936a51a497e23060d19ca0d619e250
ToppCellCOVID-19_Severe-Myeloid_G-Neutrophil|COVID-19_Severe / Disease group, lineage and cell class

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

3.93e-051891476a62f4c445ede00d15b74bee65f4e4fb54cfd4d32
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

3.93e-051891476f6b2b4824505f0119a017fdb73c55418fb651645
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

3.93e-051891476db8e314ce95c32542bb4015a77032a33211fea0b
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4|TCGA-Prostate / Sample_Type by Project: Shred V9

PHF19 CACHD1 PLEKHG5 PLCD3 EPHA2 KIFC3

4.67e-0519514765562665dd3beb70e2358aa32611a337bef5731c1
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRK2 CARD16 PTEN IFIT2 LYST MCTP2

4.95e-0519714763cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCellCOVID-19_Severe-Neu_1|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

PIK3AP1 LRRK2 CARD16 IFIT2 JUNB ARHGEF40

5.09e-051981476bbe639ea5a636c985e509fb0a133ae3b60afac5a
ToppCellCOVID-19_Severe-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

PIK3AP1 LRRK2 CARD16 IFIT2 JUNB ARHGEF40

5.23e-051991476e4d8bf016fd95a440e30014a75587e097e90cfad
ToppCellsevere-Neutrophil|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

5.38e-052001476f9af7e77a8483ab4ae708b55514e64f5420fa0c1
ToppCellSepsis-ICU-NoSEP-Myeloid-CD16+_Monocyte|ICU-NoSEP / Disease, condition lineage and cell class

PIK3AP1 PHF19 CARD16 LYST JUNB TMBIM4

5.38e-052001476f661e1737be736c62ffb04a45667a65fc3d11e2a
ToppCellCOVID-19-COVID-19_Severe-Myeloid-Neutrophil|COVID-19_Severe / Disease, condition lineage and cell class

LRRK2 CARD16 IFIT2 ARHGEF40 AP5B1 TLR5

5.38e-052001476fec2660c9a9977b3b3a2eaed063b9049c0b07ff2
Diseaseaortic valve stenosis (is_implicated_in)

APOB PPP3CB

2.15e-0451382DOID:1712 (is_implicated_in)
DiseaseLeopard Syndrome 1

PTEN EPHA2

3.22e-0461382C4551484
DiseaseBilateral Wilms Tumor

DICER1 XPO5 DGCR8

3.35e-04291383C2930471
DiseaseChild Development Disorders, Specific

CHD4 PTEN MSL3

3.35e-04291383C0085997
DiseaseChild Development Deviations

CHD4 PTEN MSL3

3.35e-04291383C0085996
DiseaseDevelopmental Disabilities

CHD4 PTEN MSL3

3.70e-04301383C0008073
DiseaseLDL cholesterol change measurement

APOB PKD1L3

4.49e-0471382EFO_0007804
DiseaseMental Retardation, X-Linked 1

RPS6KA3 IL1RAPL1 SLC9A7

4.49e-04321383C2931498
Diseasefatty liver disease (biomarker_via_orthology)

APOB PTEN SLC27A4

4.93e-04331383DOID:9452 (biomarker_via_orthology)
Diseasecitrate measurement

CYP21A2 REEP3 IL1RAPL1 WDR20

5.24e-04791384EFO_0010114
Diseasehypertension

CACNA1D AMPD3 SZT2 LCORL PLCD3 NPRL3 HERPUD2

6.25e-043071387EFO_0000537
DiseaseNephroblastoma

DICER1 XPO5 DGCR8

6.38e-04361383C0027708
DiseaseThyroid carcinoma

TSHR PTEN DICER1

1.15e-03441383C0549473
Diseaseserum gamma-glutamyl transferase measurement

PIK3AP1 PCNX3 LCORL RPS6KA3 CYP21A2 ADAM30 ARHGEF11 SLCO1B7 EPHA2 NBEAL2 SLC9A7 C3

1.25e-0391413812EFO_0004532
Diseasecomplement C1q tumor necrosis factor-related protein 1 measurement

SERPINA2 MTCH1

1.39e-03121382EFO_0801493
Diseaseunipolar depression, information processing speed, cognitive function measurement

ADCY10 CLN8 NLRP9

1.40e-03471383EFO_0003761, EFO_0004363, EFO_0008354
Diseasecancer (implicated_via_orthology)

ESRRA SSRP1 PTEN LRRC1 PARVA CDK3

1.68e-032681386DOID:162 (implicated_via_orthology)
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

LYST HPS5

2.19e-03151382DOID:2223 (implicated_via_orthology)
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

CYP21A2 PKD1L3 REEP3

2.31e-03561383EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Diseaseomega-3 polyunsaturated fatty acid measurement, diet measurement

ME1 EPHA2

2.50e-03161382EFO_0008111, EFO_0010119
Diseasesickle cell anemia (is_implicated_in)

APOB C3

2.50e-03161382DOID:10923 (is_implicated_in)
Diseasefibrinogen measurement, factor VII measurement

CYP21A2 PKD1L3 RPL6

2.56e-03581383EFO_0004619, EFO_0004623
DiseaseInsulin Resistance

PTEN IGFALS C3

2.82e-03601383C0021655
DiseaseInsulin Sensitivity

PTEN IGFALS C3

2.82e-03601383C0920563
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

AK9 PREPL

2.82e-03171382C0751883
Diseaseglutarylcarnitine (C5-DC) measurement

FNIP2 CYP21A2

2.82e-03171382EFO_0800030
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

AMPD3 CYP21A2 APOB

3.85e-03671383EFO_0008595, EFO_0020946
Diseasebreast size

HSCB SERPINA2 LMOD1

4.19e-03691383EFO_0004884
Diseaseobsolete_red blood cell distribution width

HSCB CYP21A2 APOB AK9 CHD4 SERPINA2 PLEKHG5 TXNDC11 COG1 WDR20 SIMC1 TAC3 NMT1 USP47

4.32e-03134713814EFO_0005192

Protein segments in the cluster

PeptideGeneStartEntry
HLLRYLKNPLGAFIF

PRAMEF33

286

A0A0G2JMD5
QLYLRKALSNSLHPL

ALS2CL

671

Q60I27
RYTLDFLVPAKHLLA

ARHGEF40

46

Q8TER5
QKAYFILSLGRSHPA

CTC1

241

Q2NKJ3
KLYLKALAQGTTHPL

BTBD16

106

Q32M84
LTRILPHLYLGSQKD

DUSP8

161

Q13202
KLKSRPAHLGVFLRY

ARHGEF11

316

O15085
KLLYHRLDLLGQPSA

CACHD1

626

Q5VU97
LYRIFTVNHKLLPVG

C3

146

P01024
LKELLIQIFSTPRYH

BRIX1

181

Q8TDN6
HRLFQGLGKLEYLLL

IGFALS

451

P35858
LFALPAYHTLQRKAL

CCDC142

206

Q17RM4
ALPKLNLQFLTLHDY

AQR

451

O60306
LLYSFHQLGRKLPDF

API5

346

Q9BZZ5
LQLKYPGHLAAITLS

ACTR5

226

Q9H9F9
LNRIFPYNLISLFLH

ADCY10

1161

Q96PN6
GLLSPYQILHECLKR

DGCR8

616

Q8WYQ5
QYIFSHILRLEKPAL

DICER1

851

Q9UPY3
LLYAPSLRFIHGLIK

DHX30

966

Q7L2E3
HLRNLKYLLLSDLPG

DMAC2L

176

Q99766
LPTLLHFAAKYGLKN

PIK3AP1

336

Q6ZUJ8
SGLPELKYLQIIFLH

ASPN

306

Q9BXN1
SRNSPVLLLGKCYHF

ATG4C

36

Q96DT6
ISHGLLLKKSPVLQY

AMPD3

606

Q01432
PLGFYVHLKNLSLSI

RBM12B

281

Q8IXT5
RLPQVLAHLGALKYS

C9orf64

241

Q5T6V5
LELRPKYNGILHCLT

SLC25A32

56

Q9H2D1
RHLPKTISFHYLSLP

FBLN7

331

Q53RD9
GAPKLLYVRLSHNSL

FMOD

266

Q06828
SSLHPELFYGLRKLQ

LRRTM2

146

O43300
LGLIFALILNRHKYP

TMBIM4

81

Q9HC24
YLLTRNPHLNKDLAF

ME1

16

P48163
SAVLGLLLLALPTYH

MADCAM1

326

Q13477
PFAYLLTIHLKEGRN

MCTP2

191

Q6DN12
TLRLLHKYPFILPHQ

MCTS1

81

Q9ULC4
TLRLLHKYPFILPHQ

MCTS2

81

A0A3B3IRV3
IKPLGHTLRSFLSLF

DOLK

381

Q9UPQ8
QLLTRYLKQFHLTPV

NMT1

351

P30419
LLATKKNIGRFHPYT

BLZF1

366

Q9H2G9
GLALGPILRLYKHNS

MFSD9

336

Q8NBP5
VGRSAFQYLPKLHTL

LGR6

296

Q9HBX8
ILLRYGQHPNIITLK

RPS6KA3

466

P51812
YGIPQKTLLLHLEAL

LCORL

301

Q8N3X6
YSQLILHLIKLPADF

HPS5

956

Q9UPZ3
LTQKFGPIYRLHLGL

CYP21A2

51

P08686
GFFTHYLLPQLRKQL

PCNX3

1091

Q9H6A9
YLSVHRPVQKLLRLG

FHIP2B

126

Q86V87
PHLILLYATFTQSLK

IL1RAPL1

6

Q9NZN1
TLLKLGYHFELAGPR

LMOD1

446

P29536
SLKAIRPYHALLLLS

NPRL3

251

Q12980
RQLYKNRGFLPLSHF

FGF19

151

O95750
YGAQHLLRLFVKLPE

MSL3

451

Q8N5Y2
KVLLRGFSPSHLRAY

NOD1

346

Q9Y239
IYRDLKPHNVLLFTL

LRRK2

1991

Q5S007
LTYSNFHPLLVSGRL

LY75

1031

O60449
YILLAHLAAPKLGVA

AP5B1

616

Q2VPB7
HSPLKYRVLGSLQNL

MMEL1

741

Q495T6
IYNLPESIGALLHLK

LRRC1

186

Q9BTT6
LQLTFSLQYPHFLKR

PACS1

171

Q6VY07
IKKGPFSIYLLHLAA

MRGPRG

41

Q86SM5
TPSNLLLVVHYFLIK

F2RL1

301

P55085
GSELPLHLIKSYLFQ

CDK3

96

Q00526
NLHFPKLSISGTYKL

SERPINA2

311

P20848
HPKYLELILLFDQSR

ADAM30

201

Q9UKF2
EGHLRFLKNIILPVY

APOB

3666

P04114
LKQAHALFYTLPEGL

COG1

266

Q8WTW3
ALLTHFLQPIYLKSV

ADAR

1051

P55265
LLLPFIALTNYHLTG

FITM2

71

Q8N6M3
QSILQLYKLHLPADF

FNIP2

1036

Q9P278
LRNLHKLLYNRPGTV

DEK

106

P35659
LPGHQKRIAYSLLGL

EPHA2

951

P29317
GSLRKHKDLYLPLSL

DCX

341

O43602
TRKLHTPANYLIGSL

HTR1D

66

P28221
FSKYRHRALLLPELL

LYST

391

Q99698
LSPSLQHGAKLVLYL

LYST

2781

Q99698
TPVAKQLLHLRYGNF

IFIT2

366

P09913
SALKQQELPIHRLYF

TMEM30CP

16

A0ZSE6
LVYSGRLLPDHLQLK

HERPUD2

56

Q9BSE4
HSLPSYGLENLKKLR

FSHR

231

P23945
GYSLQHKLLLTGTPL

CHD4

891

Q14839
KILYPSTLFLLRGNH

PPP3CB

146

P16298
PLLRQTAGKVLAHFY

ESRRA

386

P11474
RNILLLPLHKGSLYP

CARD16

166

Q5EG05
TFLKIIAYGLLLHPN

CACNA1D

176

Q01668
LRAISYHLVQKPFSL

TBRG4

276

Q969Z0
SLPYSLGNLHLKFLA

LRRC40

326

Q9H9A6
LLKNHLDYRPVALLF

PTEN

181

P60484
HVFPLLLSNLGYLRA

IPO8

461

O15397
HPLFKLLIPHTRYTL

ALOX15B

396

O15296
AGHLLKPRALLITYG

METTL26

126

Q96S19
LLAPLSRGLYLLKLH

HSCB

131

Q8IWL3
LLKEHATNLLGYLPK

MNS1

451

Q8NEH6
GVTALSHPLLYVKLL

MTCH1

91

Q9NZJ7
LYHSQKVLLGFVLPL

RXFP3

266

Q9NSD7
LRQNLLIFLHSPKYT

SZT2

2241

Q5T011
LLYIALHLKAFNPKG

AK9

1836

Q5TCS8
KFINEDRLPHLLLYG

RFC5

46

P40937
GHVPFRNSKLTYLLQ

KIFC3

716

Q9BVG8
YLLFSLHAIVKLGIP

FASTKD2

231

Q9NYY8
QSFHLALLRQPGIYK

SLC2A8

241

Q9NY64
LHLYSVNGKLRASLP

NBEAL2

2631

Q6ZNJ1
KSLFPGLHLRRFSYI

PKD1L3

1396

Q7Z443
HLLKLLLFYAADLNP

SIMC1

846

Q8NDZ2
YLLGKATLPGFRTIH

ST6GAL1

391

P15907
LLFIYLQPKSSHTLA

OR8K1

261

Q8NGG5
QFTTREGLYKLLPHS

WDR20

16

Q8TBZ3
FVSYFGSKLHRPKLI

SLCO1B7

36

G3V0H7
LHLLVALSQYFRAPI

PARVA

191

Q9NVD7
TKGASLIYRKFLHPL

REEP3

81

Q6NUK4
LLALASKVTLPPHYR

MRPL24

6

Q96A35
YTTVLRLFLLPHKDQ

SSRP1

236

Q08945
GLVSSLYLPHLTLFL

CLN8

221

Q9UBY8
IFYHSKPRNINGLFL

C12orf50

26

Q8NA57
ALSQFLAKHRLLYPG

CLCN1

381

P35523
LAKHRLLYPGIVTFV

CLCN1

386

P35523
VLHNPHLKLLSLYGT

NLRP9

681

Q7RTR0
LHKIVFDPRYLLLNS

TCERG1L

476

Q5VWI1
KLHTYSLFGLPRLPR

PLEKHG5

276

O94827
LYNKHLPEGKLLTAR

PDCD11

1366

Q14690
LGAVIYKTSLLHLQP

TULP4

621

Q9NRJ4
KYAASLPALLLARHT

TXNDC16

571

Q9P2K2
PLNHLYRELKFLLVL

ZWILCH

261

Q9H900
QQLLLPFYLHDLKVG

ZFHX2

1361

Q9C0A1
LRSVFALTNGIYPHK

RPL6

271

Q02878
SPRLFHQDKQLLLSY

STAG3

1016

Q9UJ98
FLRLLPELHKTGTYK

SLC27A4

581

Q6P1M0
LFKQENHLALYRLPS

TMEM94

646

Q12767
FTLPLSSLKQGYRHI

PLCD3

751

Q8N3E9
HLIYKKRISNPFQGL

STOX1

486

Q6ZVD7
GLRFLHFPYLLTLQL

USP47

376

Q96K76
LGPLFTYLHMRLSQK

XPO5

916

Q9HAV4
PHLLNALNSYKSRFL

PHF19

311

Q5T6S3
HLLRYLKNPLGAFIF

PRAMEF10

286

O60809
FTPYLGHLRNLQKLV

PRAMEF11

226

O60813
PYSLKARVLLLSHLA

SEC63

296

Q9UGP8
HLRSPLGQYKLTFDK

STAB2

2201

Q8WWQ8
KLFLQALKYSIPHLG

PREPL

6

Q4J6C6
SGLLFYIPLIHFKIR

SLC7A13

431

Q8TCU3
KPNIAHFRELYGSIL

TAMM41

206

Q96BW9
HQLKIFDLRGTYQPL

WDR46

381

O15213
ILLALHRAKKNPGYL

ZDHHC23

181

Q8IYP9
NFSVLYSPLKRHLIG

TXNDC11

666

Q6PKC3
QHLRGLRATLLKYFP

ZBED5

551

Q49AG3
QHLQLLLKYFSGDPL

TRAV8-1

61

A0A0A6YYK1
YPLSFFLNLGRRHKI

SLC9A7

461

Q96T83
QIRSLYLHPSFGKLN

TLR5

156

O60602
PDLYQLLQRLFKSHS

TAC3

41

Q9UHF0
LLVQRYLHKPYLISG

TTLL4

746

Q14679
LLILLTSHYKLNVPR

TSHR

436

P16473
GLSLHDYKLLKPSLA

JUNB

26

P17275
PLKRYAHALVFGILL

TMEM35A

111

Q53FP2