Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3C3 PIK3CA PIK3CD	3.13e-05	11	117	3	GO:0016303
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGL PYGM	1.02e-04	3	117	2	GO:0008184
MousePheno	abnormal left-right axis symmetry of the somites	SUPT20HL1 SUPT20H SUPT20HL2	1.82e-05	8	98	3	MP:0005224
MousePheno	abnormal gastrulation movements	SUPT20HL1 SUPT20H SUPT20HL2	3.87e-05	10	98	3	MP:0002174
Domain	PI3K_C2	PIK3C3 PIK3CA PIK3CD	1.31e-05	8	117	3	SM00142
Domain	PI3K_C2_dom	PIK3C3 PIK3CA PIK3CD	1.31e-05	8	117	3	IPR002420
Domain	PI3K_C2	PIK3C3 PIK3CA PIK3CD	1.31e-05	8	117	3	PF00792
Domain	PI3K_C2	PIK3C3 PIK3CA PIK3CD	1.31e-05	8	117	3	PS51547
Domain	PI3Ka	PIK3C3 PIK3CA PIK3CD	1.96e-05	9	117	3	PF00613
Domain	PI3Ka	PIK3C3 PIK3CA PIK3CD	1.96e-05	9	117	3	SM00145
Domain	-	PIK3C3 PIK3CA PIK3CD	1.96e-05	9	117	3	1.25.40.70
Domain	PI_Kinase	PIK3C3 PIK3CA PIK3CD	2.78e-05	10	117	3	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C3 PIK3CA PIK3CD	2.78e-05	10	117	3	IPR001263
Domain	PIK_HELICAL	PIK3C3 PIK3CA PIK3CD	2.78e-05	10	117	3	PS51545
Domain	Spt20	SUPT20H SUPT20HL2	3.89e-05	2	117	2	IPR021950
Domain	Tyr_Pase_non-rcpt_typ-3/4	PTPN3 PTPN4	3.89e-05	2	117	2	IPR012151
Domain	Spt20	SUPT20H SUPT20HL2	3.89e-05	2	117	2	PF12090
Domain	PI3/4_kinase_CS	PIK3C3 PIK3CA PIK3CD	1.03e-04	15	117	3	IPR018936
Domain	Sds3	BRMS1L BRMS1	1.16e-04	3	117	2	PF08598
Domain	PHOSPHORYLASE	PYGL PYGM	1.16e-04	3	117	2	PS00102
Domain	Sds3	BRMS1L BRMS1	1.16e-04	3	117	2	SM01401
Domain	Glycg_phsphrylas	PYGL PYGM	1.16e-04	3	117	2	IPR011833
Domain	Glyco_trans_35	PYGL PYGM	1.16e-04	3	117	2	IPR000811
Domain	PI3K_p85B	PIK3CA PIK3CD	1.16e-04	3	117	2	PF02192
Domain	PI3K_p85B	PIK3CA PIK3CD	1.16e-04	3	117	2	SM00143
Domain	Phosphorylase	PYGL PYGM	1.16e-04	3	117	2	PF00343
Domain	Sds3	BRMS1L BRMS1	1.16e-04	3	117	2	IPR013907
Domain	Post-SET_dom	ASH1L KMT2C SUV39H1	1.26e-04	16	117	3	IPR003616
Domain	PostSET	ASH1L KMT2C SUV39H1	1.26e-04	16	117	3	SM00508
Domain	-	PIK3C3 PIK3CA PIK3CD	1.26e-04	16	117	3	1.10.1070.11
Domain	PI3Kc	PIK3C3 PIK3CA PIK3CD	1.26e-04	16	117	3	SM00146
Domain	POST_SET	ASH1L KMT2C SUV39H1	1.26e-04	16	117	3	PS50868
Domain	PI3_PI4_kinase	PIK3C3 PIK3CA PIK3CD	1.83e-04	18	117	3	PF00454
Domain	PI3_4_KINASE_1	PIK3C3 PIK3CA PIK3CD	1.83e-04	18	117	3	PS00915
Domain	PI3_4_KINASE_2	PIK3C3 PIK3CA PIK3CD	1.83e-04	18	117	3	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3C3 PIK3CA PIK3CD	1.83e-04	18	117	3	IPR000403
Domain	PI3_4_KINASE_3	PIK3C3 PIK3CA PIK3CD	1.83e-04	18	117	3	PS50290
Domain	Bestrophin	BEST2 BEST3	2.32e-04	4	117	2	PF01062
Domain	Bestrophin/UPF0187	BEST2 BEST3	2.32e-04	4	117	2	IPR021134
Domain	Bestrophin	BEST2 BEST3	2.32e-04	4	117	2	IPR000615
Domain	PI3K_ABD	PIK3CA PIK3CD	2.32e-04	4	117	2	PS51544
Domain	PI3K_adapt-bd_dom	PIK3CA PIK3CD	2.32e-04	4	117	2	IPR003113
Domain	PI3K_Ras-bd_dom	PIK3CA PIK3CD	8.00e-04	7	117	2	IPR000341
Domain	CAMSAP_CH	ASPM VAV2	8.00e-04	7	117	2	PF11971
Domain	PI3K_rbd	PIK3CA PIK3CD	8.00e-04	7	117	2	SM00144
Domain	PI3K_rbd	PIK3CA PIK3CD	8.00e-04	7	117	2	PF00794
Domain	CAMSAP_CH	ASPM VAV2	8.00e-04	7	117	2	IPR022613
Domain	PI3K_RBD	PIK3CA PIK3CD	8.00e-04	7	117	2	PS51546
Domain	AP_complex_ssu	AP1S3 AP4S1	8.00e-04	7	117	2	IPR016635
Domain	CLAT_ADAPTOR_S	AP1S3 AP4S1	1.36e-03	9	117	2	PS00989
Domain	HAT	SART3 PDCD11	1.69e-03	10	117	2	SM00386
Domain	VDCCAlpha1	CACNA1A CACNA1H	1.69e-03	10	117	2	IPR002077
Domain	HAT	SART3 PDCD11	1.69e-03	10	117	2	IPR003107
Domain	BAH	ASH1L DNMT1	2.06e-03	11	117	2	PS51038
Domain	BAH_dom	ASH1L DNMT1	2.06e-03	11	117	2	IPR001025
Domain	BAH	ASH1L DNMT1	2.06e-03	11	117	2	SM00439
Domain	BAH	ASH1L DNMT1	2.06e-03	11	117	2	PF01426
Domain	SET	ASH1L KMT2C SUV39H1	2.15e-03	41	117	3	PF00856
Domain	Clathrin_sm-chain_CS	AP1S3 AP4S1	2.46e-03	12	117	2	IPR000804
Domain	SET	ASH1L KMT2C SUV39H1	2.99e-03	46	117	3	SM00317
Domain	PH	NET1 CNKSR2 PHLDA2 PLEKHA5 CADPS2 VAV2	3.21e-03	229	117	6	PF00169
Domain	-	NET1 CNKSR2 PHLDA2 PTPN3 PTPN4 PLEKHA5 CADPS2 VAV2	3.23e-03	391	117	8	2.30.29.30
Domain	TPR-like_helical_dom	SART3 SAMD9 PSMD6 P3H2 PDCD11 TTC9	3.50e-03	233	117	6	IPR011990
Domain	SET_dom	ASH1L KMT2C SUV39H1	3.79e-03	50	117	3	IPR001214
Domain	SET	ASH1L KMT2C SUV39H1	3.79e-03	50	117	3	PS50280
Domain	AP_mu_sigma_su	AP1S3 AP4S1	4.41e-03	16	117	2	IPR022775
Domain	Clat_adaptor_s	AP1S3 AP4S1	4.41e-03	16	117	2	PF01217
Domain	PH_dom-like	NET1 CNKSR2 PHLDA2 PTPN3 PTPN4 PLEKHA5 CADPS2 VAV2	5.39e-03	426	117	8	IPR011993
Domain	ARM-type_fold	IPO5 DNAJC13 RALGAPA2 PIK3C3 PIK3CA PIK3CD ASPM	5.51e-03	339	117	7	IPR016024
Domain	Ubiquitin-rel_dom	TBCB PTPN3 PTPN4 PIK3CA PIK3CD	6.06e-03	184	117	5	IPR029071
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD CD80	3.23e-05	10	93	3	M47615
Pathway	WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE	PIK3CA PIK3CD CD80	9.60e-05	14	93	3	M39840
Pathway	KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	CR2 PPP3CB PIK3CA PIK3CD VAV2	1.34e-04	75	93	5	M5436
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	PIK3C3 PIK3CA PIK3CD VAV2	1.35e-04	40	93	4	M39695
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20H SUPT20HL2	3.91e-08	3	119	3	24220028
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	DNAJC13 PEG3 OGDH PRPF18 ADAM22 TMPO ATL2	3.08e-07	128	119	7	30995482
Pubmed	Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.	PIK3C3 PIK3CA PIK3CD CD80	1.10e-06	23	119	4	19047410
Pubmed	Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.	SUPT20HL1 SUPT20H SUPT20HL2	2.16e-06	8	119	3	21802298
Pubmed	Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.	PIK3C3 PIK3CA PIK3CD	4.61e-06	10	119	3	8798481
Pubmed	Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.	PIK3C3 PIK3CA PIK3CD	4.61e-06	10	119	3	9247029
Pubmed	The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.	PIK3C3 PIK3CA PIK3CD	4.61e-06	10	119	3	8636073
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SART3 FLNB THOC7 SAMD9 DHX37 CAPZB FLG2 MSH6 PTPN3 IARS2 PPP3CB GLS TMPO PDCD11 PLEKHA5 DNMT1	6.28e-06	1257	119	16	36526897
Pubmed	HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.	PIK3C3 PIK3CA PIK3CD	6.32e-06	11	119	3	16081599
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	SUPT20HL1 SUPT20H SUPT20HL2	6.32e-06	11	119	3	24051374
Pubmed	Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.	PIK3C3 PIK3CA PIK3CD	6.32e-06	11	119	3	12584329
Pubmed	Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.	PIK3C3 PIK3CA PIK3CD	6.32e-06	11	119	3	9808187
Pubmed	HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.	PIK3C3 PIK3CA PIK3CD	6.32e-06	11	119	3	9708406
Pubmed	HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.	PIK3C3 PIK3CA PIK3CD	6.32e-06	11	119	3	10985305
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	SAMD9 DPY19L1 ZNF618 OGDH IARS2 GLS ASPM PEAK1	7.11e-06	288	119	8	38496616
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IPO5 SART3 FLNB DHX37 CAPZB OGDH PSMD6 MSH6 IARS2 IGF2R GLS TMPO PDCD11 PEAK1 ATL2 ITM2B DNMT1	7.36e-06	1425	119	17	30948266
Pubmed	Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.	PIK3C3 PIK3CA PIK3CD	8.40e-06	12	119	3	14602571
Pubmed	Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.	PIK3C3 PIK3CA PIK3CD	8.40e-06	12	119	3	16514418
Pubmed	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.	PIK3C3 PIK3CA PIK3CD	8.40e-06	12	119	3	10208934
Pubmed	Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.	PIK3C3 PIK3CA PIK3CD	8.40e-06	12	119	3	12077252
Pubmed	Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.	PIK3C3 PIK3CA PIK3CD	8.40e-06	12	119	3	9341793
Pubmed	Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.	PIK3C3 PIK3CA PIK3CD	8.40e-06	12	119	3	12551992
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	IPO5 SART3 FLNB SUPT20H NET1 RBM45 CAPZB CNKSR2 OGDH PSMD6 IGF2R PYGL DNMT1 FBXW11	9.18e-06	1005	119	14	19615732
Pubmed	Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.	PIK3C3 PIK3CA PIK3CD	1.09e-05	13	119	3	9394803
Pubmed	HIV-1 Nef in macrophage-mediated disease pathogenesis.	PIK3C3 PIK3CA PIK3CD	1.09e-05	13	119	3	23215766
Pubmed	Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer.	SUV39H1 DNMT1	1.16e-05	2	119	2	17657744
Pubmed	PI3 kinase alpha and delta promote hematopoietic stem cell activation.	PIK3CA PIK3CD	1.16e-05	2	119	2	31120863
Pubmed	P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse.	PIK3CA PIK3CD	1.16e-05	2	119	2	23341541
Pubmed	Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278).	PIK3CA PIK3CD	1.16e-05	2	119	2	21188463
Pubmed	Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.	PIK3CD CD80	1.16e-05	2	119	2	35742807
Pubmed	Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.	PIK3CA PIK3CD	1.16e-05	2	119	2	24043760
Pubmed	ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.	PIK3CA PIK3CD	1.16e-05	2	119	2	26883061
Pubmed	Circular RNA identified from Peg3 and Igf2r.	PEG3 IGF2R	1.16e-05	2	119	2	30216384
Pubmed	PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.	OGDH PIK3CA	1.16e-05	2	119	2	28396387
Pubmed	Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.	PIK3C3 PIK3CA PIK3CD	1.38e-05	14	119	3	17157319
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	RING1 KMT2C SUV39H1 DNMT1	1.59e-05	44	119	4	24183668
Pubmed	HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.	PIK3C3 PIK3CA PIK3CD	1.72e-05	15	119	3	18854243
Pubmed	Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice.	PEG3 PHLDA2 IGF2R DNMT1	2.07e-05	47	119	4	32892421
Pubmed	Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.	PIK3C3 PIK3CA PIK3CD	2.12e-05	16	119	3	20019835
Pubmed	Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.	PIK3C3 PIK3CA PIK3CD	2.12e-05	16	119	3	21029719
Pubmed	Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.	PIK3C3 PIK3CA PIK3CD	2.12e-05	16	119	3	20818790
Pubmed	HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.	PIK3C3 PIK3CA PIK3CD	2.12e-05	16	119	3	16524887
Pubmed	HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.	PIK3C3 PIK3CA PIK3CD	2.12e-05	16	119	3	11289809
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FLNB SLC4A7 NET1 PEG3 ASH1L KMT2C AP4S1 IGF2R PPP3CB ZNF780A PIK3CD SERINC3 ATP11A PEAK1	2.13e-05	1084	119	14	11544199
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	SART3 FLNB DNAJC13 FLG2 PSMD6 SUV39H1 TMPO PDCD11	2.35e-05	340	119	8	29478914
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	DPY19L1 OGDH TBCB AP4S1 IARS2 IGF2R STX18 MTIF2 GLS ATL2 ITM2B	2.49e-05	686	119	11	28380382
Pubmed	Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages.	PIK3C3 PIK3CA PIK3CD	2.56e-05	17	119	3	18453587
Pubmed	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.	PIK3C3 PIK3CA PIK3CD	2.56e-05	17	119	3	25327288
Pubmed	Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.	PIK3C3 PIK3CA PIK3CD	2.56e-05	17	119	3	12960231
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	SLC4A7 TMEM94 RALGAPA2 PTPN3 IGF2R PPP3CB PIK3CA PLEKHA5 ATP11A PEAK1	2.74e-05	569	119	10	30639242
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	IPO5 SART3 FLNB ZC3H12A DHX37 FLG2 PRPF18 PSMD6 MSH6 ASPM TMPO PDCD11 DNMT1	2.95e-05	971	119	13	33306668
Pubmed	Genome imprinting regulated by the mouse Polycomb group protein Eed.	PEG3 PHLDA2 IGF2R	3.07e-05	18	119	3	12627233
Pubmed	Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.	PHLDA2 IGF2R DNMT1	3.07e-05	18	119	3	23085235
Pubmed	HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.	PIK3C3 PIK3CA PIK3CD	3.07e-05	18	119	3	12526811
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	SART3 SLC4A7 DHX37 CAPZB CNKSR2 OAZ2 PSMD6 MSH6 KMT2C PTPN3 PIK3C3 ASPM SERINC3 PYGM FBXW11	3.38e-05	1284	119	15	17353931
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	IPO5 FLNB NR2C1 SUPT20H FOLH1 PEG3 ASH1L ADAM22 PPP3CB STX18 MTIF2 GLS CADPS2 DNMT1 FBXW11	3.41e-05	1285	119	15	35914814
Pubmed	Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.	CACNA1A CACNA1H	3.47e-05	3	119	2	26216687
Pubmed	Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors.	PIK3CA PIK3CD	3.47e-05	3	119	2	20103642
Pubmed	A p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of EBV-related B cell origin cancer cells via regulation of NF-κB.	PIK3CA PIK3CD	3.47e-05	3	119	2	28339079
Pubmed	Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models.	PIK3CA PIK3CD	3.47e-05	3	119	2	27176780
Pubmed	Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats.	NTF3 CADPS2	3.47e-05	3	119	2	21527636
Pubmed	The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.	PTPN3 PTPN4	3.47e-05	3	119	2	19107198
Pubmed	PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.	PIK3CA PIK3CD	3.47e-05	3	119	2	24553178
Pubmed	Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population.	CACNA1A CACNA1H	3.47e-05	3	119	2	29581247
Pubmed	PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells.	PIK3CA PIK3CD	3.47e-05	3	119	2	36812307
Pubmed	The role of different PI3K protein subtypes in the metastasis, angiogenesis and clinical prognosis of hepatocellular carcinoma.	PIK3CA PIK3CD	3.47e-05	3	119	2	34023498
Pubmed	Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication.	SUV39H1 DNMT1	3.47e-05	3	119	2	17085482
Pubmed	Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3.	NTF3 CADPS2	3.47e-05	3	119	2	30594389
Pubmed	Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.	PIK3CA PIK3CD	3.47e-05	3	119	2	15496927
Pubmed	Cloning and characterization of the murine Vmd2 RFP-TM gene family.	BEST2 BEST3	3.47e-05	3	119	2	15218265
Pubmed	Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas.	PIK3CA PIK3CD	3.47e-05	3	119	2	28515318
Pubmed	Class IA PI3Ks regulate subcellular and functional dynamics of IDO1.	PIK3CA PIK3CD	3.47e-05	3	119	2	33159421
Pubmed	Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.	PIK3CA PIK3CD	3.47e-05	3	119	2	31831213
Pubmed	HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.	PIK3C3 PIK3CA PIK3CD	3.64e-05	19	119	3	24073214
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	IPO5 SUPT20HL1 SUPT20H NET1 SUPT20HL2 RALGAPA2 ASPM TMPO	3.74e-05	363	119	8	14691545
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	IPO5 NR2C1 DHX37 RING1 MSH6 ZNF780A SUV39H1 BUD31 TMPO DNMT1	4.78e-05	608	119	10	36089195
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SART3 DNAJC13 SLC4A7 OGDH IARS2 IGF2R STX18 MTIF2 GLS ASPM TMPO PDCD11 PLEKHA5 PEAK1 ITM2B DNMT1	4.87e-05	1487	119	16	33957083
Pubmed	Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.	SUPT20HL1 SUPT20H SUPT20HL2	4.97e-05	21	119	3	23747598
Pubmed	Supt20 is required for development of the axial skeleton.	SUPT20HL1 SUPT20H SUPT20HL2	4.97e-05	21	119	3	27894818
Pubmed	Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.	PIK3C3 PIK3CA PIK3CD	4.97e-05	21	119	3	9446795
Pubmed	HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.	PIK3C3 PIK3CA PIK3CD	5.74e-05	22	119	3	11994280
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	SUPT20HL1 SUPT20H SUPT20HL2	5.74e-05	22	119	3	16751104
Pubmed	HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.	PIK3C3 PIK3CA PIK3CD	5.74e-05	22	119	3	11154208
Pubmed	PEG3 binds to H19-ICR as a transcriptional repressor.	PEG3 PRPF18 IGF2R	5.74e-05	22	119	3	27824289
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SART3 FLNB DNAJC13 DHX37 CAPZB RING1 TBCB MSH6 SMG8 GLS ASPM PDCD11 PYGL PLEKHA5 DNMT1	6.12e-05	1353	119	15	29467282
Pubmed	The functional interactome landscape of the human histone deacetylase family.	IPO5 ETV5 BRMS1L MSH6 TMPO PDCD11 BRMS1	6.45e-05	289	119	7	23752268
Pubmed	HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway.	PIK3C3 PIK3CA PIK3CD	6.58e-05	23	119	3	23301033
Pubmed	Identification and characterisation of imprinted genes in the mouse.	PEG3 PHLDA2 IGF2R	6.58e-05	23	119	3	15163367
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	FLNB DNAJC13 CAPZB OGDH TBCB PSMD6 MSH6 IARS2 IGF2R TMPO PDCD11 PYGL ATL2 VAV2 DNMT1	6.87e-05	1367	119	15	32687490
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1A CACNA1H	6.93e-05	4	119	2	31800012
Pubmed	Role for DNA methylation in genomic imprinting.	IGF2R DNMT1	6.93e-05	4	119	2	8247133
Pubmed	A glutaminase (gis) gene maps to mouse chromosome 1, rat chromosome 9, and human chromosome 2.	GLS C4BPA	6.93e-05	4	119	2	2571577
Pubmed	p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.	PIK3CA PIK3CD	6.93e-05	4	119	2	9235916
Pubmed	Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.	BEST2 BEST3	6.93e-05	4	119	2	12032738
Pubmed	Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1.	BEST2 BEST3	6.93e-05	4	119	2	19237432
Pubmed	MRTF-A and STAT3 promote MDA-MB-231 cell migration via hypermethylating BRSM1.	DNMT1 BRMS1	6.93e-05	4	119	2	25854163
Pubmed	Structure-function analysis of the bestrophin family of anion channels.	BEST2 BEST3	6.93e-05	4	119	2	12907679
Pubmed	Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation.	PIK3CA PIK3CD	6.93e-05	4	119	2	32414808
Pubmed	The PI3K inhibitor arsenal: choose your weapon!	PIK3CA PIK3CD	6.93e-05	4	119	2	17920279
Pubmed	The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.	PIK3CA PIK3CD	6.93e-05	4	119	2	20699475
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C3 PIK3CA PIK3CD	5.72e-06	8	86	3	831
GeneFamily	Glycogen phosphorylases	PYGL PYGM	6.69e-05	3	86	2	437
GeneFamily	Bestrophins	BEST2 BEST3	1.33e-04	4	86	2	866
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 CNKSR2 PHLDA2 PLEKHA5 CADPS2 VAV2	4.48e-04	206	86	6	682
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	ASH1L KMT2C SUV39H1	5.59e-04	34	86	3	487
GeneFamily	LIM class homeoboxes	LHX8 LHX5	1.43e-03	12	86	2	522
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN3 PTPN4	3.26e-03	18	86	2	812
Coexpression	GSE17721_LPS_VS_PAM3CSK4_1H_BMDC_DN	ZC3H12A DNAJC13 RING1 TDRD7 PIK3CA CD80 CACNA1H CADPS2 DNMT1	3.06e-07	199	118	9	M3912
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_LOW_DOSE_MAC_DN	NR2C1 TBCB MTIF2 PYGL PYGM ADGRF5 ATP11A FBXW11	3.44e-06	199	118	8	M5251
Coexpression	SENESE_HDAC3_TARGETS_UP	DNAJC13 KLHL28 AP1S3 FAT3 DCP2 ASH1L OGDH IGF2R GLS SERINC3 FBXW11	1.52e-05	495	118	11	M8451
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	IPO5 FLNB THOC7 DNAJC13 SLC4A7 SUPT20H DCP2 CAPZB ADAM22 PPP3CB STX18 PIK3CA P3H2 GLS BUD31 TMPO SERINC3	3.15e-05	1215	118	17	M41122
Coexpression	GSE360_T_GONDII_VS_B_MALAYI_LOW_DOSE_MAC_DN	CR2 TBCB PTPN4 PDCD11 PCYT2 PYGM TMEM184B	3.39e-05	199	118	7	M5257
Coexpression	GSE5142_CTRL_VS_HTERT_TRANSDUCED_CD8_TCELL_EARLY_PASSAGE_CLONE_UP	SLC4A7 TDRD7 MSH6 CD80 SERINC3 PEAK1 VAV2	3.50e-05	200	118	7	M6549
Coexpression	GSE21670_IL6_VS_TGFB_AND_IL6_TREATED_STAT3_KO_CD4_TCELL_UP	AP1S3 GINS1 SUV39H1 TMPO PCYT2 SERINC3 NAA40	3.50e-05	200	118	7	M7449
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 PTPN3 P3H2 ATP11A C4BPA CADPS2 ATP1B1	5.40e-07	179	119	7	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	CACNA1A FLNB NTF3 FAT3 P3H2 GLS ENPEP	6.26e-07	183	119	7	818fd886e0188091310825f9145fa53328f2c979
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1A FLNB NTF3 FAT3 P3H2 GLS ENPEP	6.26e-07	183	119	7	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 PTPN3 P3H2 ATP11A C4BPA CADPS2 ATP1B1	6.50e-07	184	119	7	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	IPF-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ETV5 CHI3L2 P3H2 GLS ADGRF5 ATP11A C4BPA	7.51e-07	188	119	7	5f5fad2773e421760e67dbace23fd1f847a2e1e0
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	DHX37 CAPZB RFX8 STX18 BUD31 TMEM184B BRMS1	7.51e-07	188	119	7	3df5a5b645403914c4d0506e2d93f8a8a98e3fa6
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SLC27A6 PEG3 IGF2R PLEKHA5 PRKG2 PEAK1 ENPEP	8.35e-07	191	119	7	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NET1 NTF3 OAZ2 PHLDA2 PYGM CACNA1H ENPEP	8.64e-07	192	119	7	5995bae840c0b3f420288f557634d0ae9a12a6ae
ToppCell	AT2\|World / shred by cell class for parenchyma	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA ATP1B1	9.27e-07	194	119	7	e773f5ef3abce7113a6b7cc7cbe68de873d4a17f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 GLS ADGRF5 ATP11A C4BPA	9.92e-07	196	119	7	7e5addaa844e66f8160e05858c341866a80aed23
ToppCell	ASK440-Epithelial-Type_2\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	ETV5 CHI3L2 P3H2 GLS ADGRF5 ATP11A C4BPA	1.03e-06	197	119	7	08d5bbeb77a4152af1c783bc958afcae24667767
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNB SAMD9 PHLDA2 GUCY2C C4BPA PRKG2 ATP1B1	1.06e-06	198	119	7	efdbac7a3a02bff4ca48841772e0c136556c2b9b
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNB SAMD9 PHLDA2 GUCY2C C4BPA PRKG2 ATP1B1	1.06e-06	198	119	7	a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCell	ASK428-Epithelial-Type_2\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA CADPS2	1.06e-06	198	119	7	ec0d1801363adb70c6a26655b79d12b438c7417d
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 GLS ADGRF5 ATP11A C4BPA	1.10e-06	199	119	7	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	AP1S3 ZNF618 PTPN4 PPP3CB PIK3CD PRKG2	7.92e-06	176	119	6	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZC3H12A ETV5 PTPN3 P3H2 C4BPA ATP1B1	8.72e-06	179	119	6	7db6b97a1c4c7a163d5da4351ba36ac1785d9d7b
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ETV5 P3H2 ADGRF5 ATP11A C4BPA CADPS2	9.00e-06	180	119	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	SLC27A6 PEG3 IGF2R PRKG2 PEAK1 ENPEP	9.59e-06	182	119	6	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 PTPN3 P3H2 ATP11A C4BPA CADPS2	9.59e-06	182	119	6	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 PTPN3 P3H2 C4BPA CADPS2 ATP1B1	9.89e-06	183	119	6	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 PTPN3 P3H2 ATP11A C4BPA CADPS2	1.05e-05	185	119	6	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.05e-05	185	119	6	7460387f48f33674330bd53b759681b264228f5a
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPN3 P3H2 ATP11A C4BPA CADPS2 ATP1B1	1.08e-05	186	119	6	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 PTPN3 P3H2 ATP11A CADPS2 ATP1B1	1.15e-05	188	119	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	tumor_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	OAZ2 IGF2R P3H2 ADGRF5 CACNA1H ENPEP	1.19e-05	189	119	6	9c407b17d7945e81e1ae6c18452f5d20fb09d563
ToppCell	AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ETV5 P3H2 ADGRF5 ATP11A C4BPA PRKG2	1.19e-05	189	119	6	2d32f09efa982ae458568f6b1cd06bb5078d42a3
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ETV5 PTPN3 P3H2 ADGRF5 ATP11A CADPS2	1.26e-05	191	119	6	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NET1 NTF3 OAZ2 PHLDA2 PYGM ENPEP	1.26e-05	191	119	6	239c1e68eb1cbe3e137a99fbd6eeb8d64c919ffd
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	PTPN3 P3H2 ADGRF5 ATP11A C4BPA ATP1B1	1.26e-05	191	119	6	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC27A6 FAT3 PEG3 PRKG2 PEAK1 ENPEP	1.30e-05	192	119	6	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ETV5 PTPN3 P3H2 ADGRF5 C4BPA CADPS2	1.30e-05	192	119	6	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NET1 NTF3 OAZ2 PHLDA2 CACNA1H ENPEP	1.30e-05	192	119	6	dee97f650ae6f4d07a142ade402aae1905791a22
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC27A6 FAT3 PEG3 PRKG2 PEAK1 ENPEP	1.30e-05	192	119	6	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ETV5 PTPN3 P3H2 ADGRF5 ATP11A CADPS2	1.30e-05	192	119	6	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	(7)_Epithelial-C_(AT2)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.34e-05	193	119	6	a3ca6ab20c8de260e410ddc14d3d202f28b9d6c2
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ETV5 P3H2 ADGRF5 ATP11A C4BPA CADPS2	1.34e-05	193	119	6	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ETV5 P3H2 ADGRF5 ATP11A C4BPA CADPS2	1.34e-05	193	119	6	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	(7)_Epithelial_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.38e-05	194	119	6	413e8b9f1e15be363a7f4a8f727af3eeb9e9a928
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ETV5 P3H2 ADGRF5 ATP11A C4BPA CADPS2	1.38e-05	194	119	6	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.38e-05	194	119	6	0db439a544cf8f918a77058fd70319ab0e8e645e
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ETV5 CHI3L2 P3H2 GLS ADGRF5 ATP11A	1.38e-05	194	119	6	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	(7)_Epithelial-A_(AT2)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ETV5 P3H2 ADGRF5 ATP11A C4BPA ATP1B1	1.42e-05	195	119	6	c9a6c65ee18d83bf34a4713d306a6e30db1325c2
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC27A6 FAT3 PEG3 PRKG2 PEAK1 ENPEP	1.42e-05	195	119	6	3a0cad69cfc150a27a0666f612f5294c817197d7
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	6617abca0009ad3d8731f515f91ab275f9ea4c40
ToppCell	normal_Lung-Epithelial_cells-AT2\|Epithelial_cells / Location, Cell class and cell subclass	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	81e13fe337f1d0a83d0deb86a0df797d306cd24d
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	6867f9c56ea27a17c8c4099aae0d79903c3748a5
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	fc0ae145a2118df7cbbc9ac4ca9dc12d26c087c4
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC27A6 FAT3 PEG3 PRKG2 PEAK1 ENPEP	1.42e-05	195	119	6	2b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCell	390C-Epithelial_cells-Epithelial-C_(AT2)\|390C / Donor, Lineage, Cell class and subclass (all cells)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	d0608db4a61576e67f4a3a52e1f84d788a1dea85
ToppCell	390C-Epithelial_cells-Epithelial-C_(AT2)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	bdfe486d32cb598950c1a5f5cdab40302c8f0f99
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 GLS ADGRF5 ATP11A C4BPA ATP1B1	1.42e-05	195	119	6	d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	3e24570def013d5b0b1ef1d7a5ced7dfd922590b
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	955a0a7244cd7eaf006a39e1bd03333baf6f30a4
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	37aa6e4123d37de4de42ca68d3020f2a7686ce02
ToppCell	3'-Parenchyma_lung-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.42e-05	195	119	6	eec187c087e432417bc346c5d3ead72f58bf3215
ToppCell	356C-Epithelial_cells-Epithelial-A_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ETV5 P3H2 ADGRF5 ATP11A C4BPA ATP1B1	1.46e-05	196	119	6	93a5d9b8bcff7d07596ef1f4f2b74f043835fc69
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.46e-05	196	119	6	82b117be41f2e7d677a42d2a5198726eeccb16d0
ToppCell	ASK440-Epithelial-Type_2\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.46e-05	196	119	6	754b4202b617165c6994a0b5a9b1e486dccdd44d
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SLC27A6 PEG3 IGF2R PRKG2 PEAK1 ENPEP	1.46e-05	196	119	6	54f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCell	356C-Epithelial_cells-Epithelial-A_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ETV5 P3H2 ADGRF5 ATP11A C4BPA ATP1B1	1.46e-05	196	119	6	4715f19f844e7244fc4bc446cba7c8088c600fc3
ToppCell	cellseq-Epithelial-Epithelial_Alveolar\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.46e-05	196	119	6	a7cbe66ebd8931ef2b8ff26a42afce0ad1c48f17
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.46e-05	196	119	6	69f27c2668a9f412b2eb6ca83d11b44863209542
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 P3H2 GLS ADGRF5 ATP11A C4BPA	1.46e-05	196	119	6	65e161fd672e37a5d10f28011bb422c4d7042d6a
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.50e-05	197	119	6	0d59a2669de60046e8140d82e67c2b5da4a5683c
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB RALGAPA2 SERINC3 ADGRF5 PEAK1 ENPEP	1.50e-05	197	119	6	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB RALGAPA2 SERINC3 ADGRF5 PEAK1 ENPEP	1.50e-05	197	119	6	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	390C-Epithelial_cells\|390C / Donor, Lineage, Cell class and subclass (all cells)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.50e-05	197	119	6	78554b26b04752e7cd80402c93a3a491560e8f5f
ToppCell	Bronchial_Biopsy-Mesenchymal-Smooth_muscle\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	NET1 PHLDA2 PTPN3 ADGRF5 CACNA1H ENPEP	1.50e-05	197	119	6	98f0184a09563a544f0c2d4df22c9db2fbc95019
ToppCell	AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DPY19L1 ETV5 P3H2 ADGRF5 ATP11A C4BPA	1.50e-05	197	119	6	42e49a8ce3118db6c2fd620d70c480b75143c828
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.50e-05	197	119	6	87c4eafe46f622f9830df75e1ca589e064651db4
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ETV5 PTPN3 P3H2 ATP11A CADPS2 ATP1B1	1.50e-05	197	119	6	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHI3L2 P3H2 GLS ADGRF5 ATP11A C4BPA	1.50e-05	197	119	6	bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCell	distal-Epithelial-Alveolar_Epithelial_Type_2-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ETV5 CHI3L2 PHLDA2 P3H2 ATP11A C4BPA	1.55e-05	198	119	6	19eefd05573fbaed654af52bf0f8a26092b8b229
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NET1 ETV5 P3H2 ATP11A CADPS2 ATP1B1	1.55e-05	198	119	6	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_late\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NET1 ETV5 P3H2 ADGRF5 ATP11A ATP1B1	1.55e-05	198	119	6	1851b7f4198b42c21c934e2fbda39dbd65e2625c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1A PEG3 CNKSR2 ADAM22 GLS PLEKHA5	1.55e-05	198	119	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ETV5 P3H2 ADGRF5 ATP11A C4BPA CADPS2	1.55e-05	198	119	6	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1A PEG3 CNKSR2 ADAM22 GLS PLEKHA5	1.55e-05	198	119	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ETV5 P3H2 ADGRF5 ATP11A C4BPA CADPS2	1.55e-05	198	119	6	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN3 P3H2 ADGRF5 ATP11A C4BPA CADPS2	1.59e-05	199	119	6	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Biopsy_Other_PF-Epithelial-AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.59e-05	199	119	6	9a65acfe9bf500db72142469cf17bf0973540001
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	SAMD9 SLC4A7 ASH1L PTPN4 HERC6 ZNF107	1.59e-05	199	119	6	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	TCGA-Stomach-Primary_Tumor\|TCGA-Stomach / Sample_Type by Project: Shred V9	SART3 GINS1 ASPM PDCD11 ATP11A DNMT1	1.59e-05	199	119	6	38f1f612b29feb868322999ceeda78e52447ec4f
ToppCell	Biopsy_IPF-Epithelial-AT2\|Biopsy_IPF / Sample group, Lineage and Cell type	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.59e-05	199	119	6	c841d475703d3489161fb7904526bd7563d5fb0f
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma\|TCGA-Stomach / Sample_Type by Project: Shred V9	SART3 GINS1 ASPM PDCD11 ATP11A DNMT1	1.59e-05	199	119	6	b10698aee2e6c17bc559eb4f723024141f914b90
ToppCell	proximal-3-Epithelial-Alveolar_Epithelial_Type_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.64e-05	200	119	6	e1ede812cd2ff65af63d2fd85145ad1e0049468f
ToppCell	proximal-Epithelial-Signaling_Alveolar_Epithelial_Type_2-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.64e-05	200	119	6	7bd76884fcffdbd9b8d24f5b6b5187ad3963da5f
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ETV5 PHLDA2 P3H2 ATP11A CADPS2 ATP1B1	1.64e-05	200	119	6	b6cfe5e205ade8bcb75555564f3f57f03f6e40be
ToppCell	proximal-Epithelial-Signaling_Alveolar_Epithelial_Type_2\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.64e-05	200	119	6	af57f837eb7f988d24fc4612d16d68121498f0b0
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SAMD9 JAKMIP2 PTPN4 IGF2R PEAK1 HERC6	1.64e-05	200	119	6	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	proximal-Epithelial-Alveolar_Epithelial_Type_2\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.64e-05	200	119	6	685bf05615688a1668ba6756d1ba77dff200faf9
ToppCell	proximal-Epithelial-Alveolar_Epithelial_Type_2-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.64e-05	200	119	6	0780490f262115bd8feb6302feae2e398aa67e92
ToppCell	proximal-3-Epithelial-Signaling_Alveolar_Epithelial_Type_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ETV5 CHI3L2 P3H2 ADGRF5 ATP11A C4BPA	1.64e-05	200	119	6	9c7859659843b1566bdf623b269b5e166c89d38c
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BEST2 ASPM TMPO PYGL MYBPC2	4.56e-05	146	119	5	45d7cb73776e60d22f335a651845e21e16948fcc
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FAT3 CNKSR2 PTPN3 CACNA1H PEAK1	4.71e-05	147	119	5	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	lung-Type_II_Pneumocytes\|lung / shred on tissue and cell subclass	ETV5 P3H2 ADGRF5 ATP11A ENPEP	4.71e-05	147	119	5	8a3039de45b8087f8319e2e37329acf7278219b7
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_mature_unknown_2\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC27A6 BRMS1L PYGM PRKG2 ENPEP	7.04e-05	160	119	5	68b477525eeef99430382ff0a6745cac91364bc2
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC27A6 FAT3 PYGM PRKG2 ENPEP	7.25e-05	161	119	5	b19f82dd98a3064581793711bb70373f18abecd9
ToppCell	Healthy_Control-Lymphoid-B-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CNKSR2 CR2 GUCY2C PYGM TTC9	7.68e-05	163	119	5	d84bd41b4494c7d5c7f88d511bfe481fb12f079d
Drug	N-methyl-DL-aspartic acid	CACNA1A FOLH1 NTF3 PHLDA2 OGDH ADAM22 PTPN3 GUCY2C PIK3C3 PIK3CA PIK3CD GLS CACNA1H PRKG2 CARD14	1.22e-06	655	116	15	CID000004376
Drug	adenine	ETV5 XK OGDH PTPN4 IGF2R GUCY2C MTIF2 GLS PYGL PYGM ENPEP DNMT1 MYBPC2	2.07e-06	510	116	13	CID000000190
Drug	Clomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; HL60; HT_HG-U133A	FLNB SLC4A7 PIK3CD ATP11A ATP1B1 ATL2 ITM2B FBXW11	6.71e-06	193	116	8	1269_UP
Drug	N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamide	PIK3C3 PIK3CA PIK3CD	1.51e-05	10	116	3	ctd:C558744
Drug	1-N-Acetyl-Beta-D-Glucosamine	PYGL PYGM	2.57e-05	2	116	2	DB02320
Drug	lavendustin A	CACNA1A PTPN3 PIK3C3 PIK3CA PIK3CD CACNA1H PRKG2	2.80e-05	171	116	7	CID000003894
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	CACNA1A PTPN3 GUCY2C PIK3C3 PIK3CA PIK3CD CACNA1H PRKG2 CARD14	2.90e-05	308	116	9	CID000001915
Drug	AC1NBU2S	CACNA1A GUCY2C PYGL PYGM CACNA1H CARD14	3.03e-05	117	116	6	CID004473765
Drug	thymine	OGDH MSH6 KMT2C PTPN4 MTIF2 TMPO PYGL PYGM DNMT1	3.46e-05	315	116	9	CID000001135
Drug	halenaquinone	PIK3C3 PIK3CA PIK3CD	4.50e-05	14	116	3	CID000370346
Drug	4-hydroxyisoleucine	PIK3C3 PIK3CA PIK3CD	5.61e-05	15	116	3	CID000354197
Drug	Gvapspat amide	PYGL PYGM PRKG2	5.61e-05	15	116	3	CID000125015
Drug	Nalidixic acid sodium salt hydrate; Up 200; 14.6uM; PC3; HT_HG-U133A	CNKSR2 CHI3L2 ADAM22 PIK3CD ADGRF5 ATP11A C4BPA	6.65e-05	196	116	7	3668_UP
Drug	rapamycin; Up 200; 0.1uM; MCF7; HG-U133A	NR2C1 SLC4A7 JAKMIP2 ADAM22 SERINC3 ATL2 ITM2B	7.32e-05	199	116	7	326_UP
Drug	Acenocoumarol [152-72-7]; Down 200; 11.4uM; PC3; HT_HG-U133A	ZC3H12A PEG3 ETV5 TMPO NAA40 CALML4 ITM2B	7.32e-05	199	116	7	2077_DN
Drug	Simvastatin [79902-63-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	NR2C1 DNAJC13 XK JAKMIP2 ATP11A HERC6 TMEM184B	7.55e-05	200	116	7	4828_DN
Drug	3,5-dimethylphenyl isocyanate	PYGL PYGM	7.69e-05	3	116	2	CID000521488
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGL PYGM	7.69e-05	3	116	2	CID000147839
Drug	NSC758405	PYGL PYGM	7.69e-05	3	116	2	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGL PYGM	7.69e-05	3	116	2	CID000151920
Drug	pyridoxal phosphoglucose	PYGL PYGM	7.69e-05	3	116	2	CID000196007
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGL PYGM	7.69e-05	3	116	2	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGL PYGM	7.69e-05	3	116	2	CID000191554
Drug	hydan	PYGL PYGM	7.69e-05	3	116	2	CID000008360
Drug	EHMF	PYGL PYGM	7.69e-05	3	116	2	CID000033931
Drug	pyridoxal 5'-methylenephosphonate	PYGL PYGM	7.69e-05	3	116	2	CID003082249
Drug	Plp 5'-mpa	PYGL PYGM	7.69e-05	3	116	2	CID003082151
Drug	glucose-1,2-cyclic phosphate	PYGL PYGM	7.69e-05	3	116	2	CID000191723
Drug	3'-FFdUrd	PYGL PYGM	7.69e-05	3	116	2	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGL PYGM	7.69e-05	3	116	2	CID000119518
Drug	AC1L8XK3	PYGL PYGM	7.69e-05	3	116	2	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGL PYGM	7.69e-05	3	116	2	CID000446801
Drug	riboflavin tetraacetate	PYGL PYGM	7.69e-05	3	116	2	CID000094186
Drug	2,5-dimethyl-3-furanone	PYGL PYGM	7.69e-05	3	116	2	CID000085730
Drug	3,5-dinitrophenol	PYGL PYGM	7.69e-05	3	116	2	CID000011459
Drug	ZSTK474	PIK3C3 PIK3CA PIK3CD	8.32e-05	17	116	3	CID011647372
Drug	NVP-BEZ235	PIK3C3 PIK3CA PIK3CD	9.94e-05	18	116	3	CID011977753
Drug	ML-9	PTPN3 IGF2R PIK3C3 PIK3CA PIK3CD PRKG2	1.08e-04	147	116	6	CID000004217
Drug	AC1NUZ8M	CACNA1A GUCY2C CACNA1H PRKG2 CARD14	1.09e-04	92	116	5	CID000073211
Drug	ADP alpha S	PTPN4 PYGL PYGM	1.18e-04	19	116	3	CID000171069
Drug	periodate-oxidized adenosine	FLNB SLC4A7 PHLDA2 GINS1 PPP3CB GLS PCYT2	1.33e-04	219	116	7	ctd:C027579
Drug	PX-866	PIK3C3 PIK3CA PIK3CD	1.38e-04	20	116	3	CID009849735
Drug	AC1L1DXE	CACNA1A FOLH1 PIK3C3 PIK3CA PIK3CD PYGL PYGM CACNA1H	1.50e-04	299	116	8	CID000002548
Drug	galocitabine	PYGL PYGM	1.53e-04	4	116	2	CID000065950
Drug	5-deoxyribose-1-phosphate	PYGL PYGM	1.53e-04	4	116	2	CID000135786
Drug	ingliforib	PYGL PYGM	1.53e-04	4	116	2	CID006451325
Drug	uric acid riboside	PYGL PYGM	1.53e-04	4	116	2	CID000164933
Drug	pseudo-dl-glucose	PYGL PYGM	1.53e-04	4	116	2	CID000125259
Drug	Trimm	FOLH1 PRKG2	1.53e-04	4	116	2	CID000017804
Drug	pyridoxal diphosphate	PYGL PYGM	1.53e-04	4	116	2	CID000125696
Drug	NVP-BKM120	PIK3CA PIK3CD	1.53e-04	4	116	2	ctd:C571178
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGL PYGM	1.53e-04	4	116	2	CID000189134
Drug	AC1LAMW2	PYGL PYGM	1.53e-04	4	116	2	CID000491364
Drug	FdUrd-C8	PYGL PYGM	1.53e-04	4	116	2	CID000094262
Drug	Mem-CC	PYGL PYGM	1.53e-04	4	116	2	CID003081269
Drug	methylhistaprodifen	NTF3 GLS	1.53e-04	4	116	2	ctd:C118995
Drug	BCIp4A	PYGL PYGM	1.53e-04	4	116	2	CID000192417
Drug	3'-chloromethotrexate	PYGL PYGM	1.53e-04	4	116	2	CID000097703
Drug	AC1MU1S9	NTF3 PEG3 OGDH PTPN3 GUCY2C PIK3C3 PIK3CA PIK3CD CD80 PRKG2 CARD14	1.66e-04	572	116	11	CID000003733
Drug	3-O-methyl-alpha-D-glucopyranose	PIK3C3 PIK3CA PIK3CD PYGL	2.05e-04	57	116	4	CID000083246
Drug	28 N	PTPN3 GUCY2C CARD14	2.41e-04	24	116	3	CID000004551
Drug	heptulose-2-P	PYGL PYGM	2.55e-04	5	116	2	CID000124823
Drug	6-FPLP	PYGL PYGM	2.55e-04	5	116	2	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGL PYGM	2.55e-04	5	116	2	CID009576855
Drug	DHPBU	PYGL PYGM	2.55e-04	5	116	2	CID000125914
Drug	5'-isobutylthioinosine	PYGL PYGM	2.55e-04	5	116	2	CID003080910
Drug	indirubin-5-sulphonate	PYGL PYGM	2.55e-04	5	116	2	CID005288641
Drug	AC1LCUXJ	PYGL PYGM	2.55e-04	5	116	2	CID000656425
Drug	6-amino-5-bromouracil	PYGL PYGM	2.55e-04	5	116	2	CID000080578
Drug	etafenone	PYGL PYGM	2.55e-04	5	116	2	CID000003275
Drug	ddEtUrd	PYGL PYGM	2.55e-04	5	116	2	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGL PYGM	2.55e-04	5	116	2	CID000125618
Drug	m-anisidine	PYGL PYGM	2.55e-04	5	116	2	CID000010824
Drug	2-hydroxypropylphosphonate	PYGL PYGM	2.55e-04	5	116	2	CID000441028
Drug	6-FDPL	PYGL PYGM	2.55e-04	5	116	2	CID000129578
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGL PYGM	2.55e-04	5	116	2	CID003082179
Drug	GlcMan	PYGL PYGM	2.55e-04	5	116	2	CID000152120
Drug	U66985	PYGL PYGM	2.55e-04	5	116	2	CID000127224
Drug	4-chloronitrosobenzene	FOLH1 OGDH	2.55e-04	5	116	2	CID000013614
Drug	AC1O3M08	PYGL PYGM	2.55e-04	5	116	2	CID006331955
Drug	Piroxicam	FLNB NET1 PHLDA2 GINS1 PRPF18 MSH6 ASPM TMPO ATP1B1 DNMT1 BRMS1	2.62e-04	603	116	11	ctd:D010894
Drug	IAA-94	CACNA1A BEST2 BEST3 CACNA1H	2.67e-04	61	116	4	CID000003667
Disease	Spastic tetraparesis	PCYT2 ITM2B	4.66e-05	3	117	2	C0575059
Disease	Cholangiocarcinoma	PEG3 KMT2C PTPN3	1.48e-04	26	117	3	C0206698
Disease	Prostatic Neoplasms	SAMD9 FOLH1 ASH1L ETV5 KMT2C IGF2R PIK3CA PIK3CD SERINC3 DNMT1	1.76e-04	616	117	10	C0033578
Disease	Malignant neoplasm of prostate	SAMD9 FOLH1 ASH1L ETV5 KMT2C IGF2R PIK3CA PIK3CD SERINC3 DNMT1	1.76e-04	616	117	10	C0376358
Disease	Akinetic Petit Mal	CACNA1A CACNA1H	3.23e-04	7	117	2	C0001890
Disease	Epilepsy, Absence, Atypical	CACNA1A CACNA1H	3.23e-04	7	117	2	C0751124
Disease	Absence Seizure Disorder	CACNA1A CACNA1H	3.23e-04	7	117	2	C4553705
Disease	Juvenile Absence Epilepsy	CACNA1A CACNA1H	3.23e-04	7	117	2	C4317339
Disease	Childhood Absence Epilepsy	CACNA1A CACNA1H	3.23e-04	7	117	2	C4281785
Disease	Epilepsy, Minor	CACNA1A CACNA1H	3.23e-04	7	117	2	C4552765
Disease	Absence Epilepsy	CACNA1A CACNA1H	3.23e-04	7	117	2	C0014553
Disease	HEPATOCELLULAR CARCINOMA	IGF2R PIK3CA	5.51e-04	9	117	2	114550
Disease	Liver Diseases, Parasitic	PEG3 KMT2C	5.51e-04	9	117	2	C0023897
Disease	Hepatocellular carcinoma	IGF2R PIK3CA	5.51e-04	9	117	2	cv:C2239176
Disease	Influenza	SAMD9 TDRD7 HERC6	1.17e-03	52	117	3	C0021400
Disease	xanthine measurement	CNKSR2 ADAM22	1.18e-03	13	117	2	EFO_0010548
Disease	body mass index, osteoarthritis	WSCD2 CACNA1H CADPS2	1.30e-03	54	117	3	EFO_0004340, MONDO_0005178
Disease	filaggrin gene expression measurement	ZNF618 CARD14	1.80e-03	16	117	2	EFO_0020899
Disease	Global developmental delay	TMEM94 AP4S1 PCYT2 FBXW11	1.97e-03	133	117	4	C0557874
Disease	phosphoglyceric acid measurement	NTF3 ZNF107	2.04e-03	17	117	2	EFO_0010523
Disease	Fetal Growth Retardation	SAMD9 GINS1	2.83e-03	20	117	2	C0015934
Disease	colorectal carcinoma (is_implicated_in)	MSH6 PIK3CA	3.42e-03	22	117	2	DOID:0080199 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVQKRYFEKLSIYCD	BEST3	56	Q8N1M1
EFEKDCRGKYLLYEK	CACNA1A	1411	O00555
CRGKYLLYEKNEVKA	CACNA1A	1416	O00555
FKEEIIYECDKGYIL	C4BPA	446	P04003
EGQKRYFEKLVIYCD	BEST2	56	Q8NFU1
EYCIKEGYADKNLIA	BUD31	76	P41223
RPKGVKEQDVYICDY	ASH1L	2771	Q9NR48
KEQDVYICDYRLDKS	ASH1L	2776	Q9NR48
EIRIECKAYGENIGY	ATP1B1	271	P05026
AVKVLLKRCQYEPDY	ANKRD16	186	Q6P6B7
YKECFSLYDKQQRGK	CALML4	56	Q96GE6
YYKKVCIDAETLEVG	DNMT1	746	P26358
DKYCYEKLNIEGTEK	ADAM22	566	Q9P0K1
FLAYYEICQFLKGAK	CHI3L2	301	Q15782
DFYYECKQERIKEYE	CDADC1	226	Q9BWV3
FDIKDYICKDDYIEL	DCP2	151	Q8IU60
EGTYECVVLKYEKDA	CD80	111	P33681
RDKVVGKDYLLCDYN	CAPZB	51	P47756
CIQSYYRGFKVRKDI	ASPM	2671	Q8IZT6
LREKFKVYGDIEYCS	RBM45	136	Q8IUH3
KLCIDGYEYAYLKAI	NR2C1	491	P13056
ECQFLYEVRGETYLK	GUCY2C	976	P25092
YKFVCEAILRVYEEG	PTPN3	891	P26045
YRFVCEAILKVYEEG	PTPN4	901	P29074
DRNFAIGYYLKEKKC	GLS	386	O94925
KKGESECQYYIDKLE	NET1	356	Q7Z628
RYVELLDKYFGNVCE	AP1S3	86	Q96PC3
QCSFIEYKDFKLIYR	AP4S1	46	Q9Y587
KVNYVFICFRKGRED	OAZ2	131	O95190
IRDPEGKYKVNCYLD	PCDH20	456	Q8N6Y1
EKEKYRYTVRAVDCG	PCDH20	601	Q8N6Y1
VIDVFYKYTKQDGEC	FLG2	11	Q5D862
FCKIKGYLEEELDYR	JAKMIP2	691	Q96AA8
IQKGEELCYDYKFDF	KMT2C	4876	Q8NEZ4
YYKDIVENICGREKS	TMPO	321	P42166
KKELLAYDVVCEDYG	MTIF2	301	P46199
VYYCGIKYIKDDVIL	ITM2B	86	Q9Y287
GESLSVQCRYEEKYK	CD300H	36	A0A0K2S4Q6
YRAVLQDIIKDCYGI	METTL25	476	Q8N6Q8
DCRDYAVVLRKYADK	FOLH1	596	Q04609
VEDKGNQVYRCVYKP	FLNB	406	O75369
YEEVKQAGRYRECKR	PCYT2	126	Q99447
QYKKCDEFQTGILIY	PEAK1	1586	Q9H792
EGNYQKEKDLCIKYF	FBXW11	66	Q9UKB1
KGVYCLQYDDEKIIS	FBXW11	241	Q9UKB1
VYEEFQRGFYRVCEK	HERC6	871	Q8IVU3
AVYVVGYIDICKLRK	DPY19L1	271	Q2PZI1
YVIDENKFVCKDDYL	LHX5	106	Q9H2C1
YIKDKDIFCKLDYFR	LHX8	116	Q68G74
QKVAGERYVYKFVCD	ETV5	436	P41161
QVRRCFEYKKQEYVV	ENPEP	156	Q07075
YYRVGEYVKALECAK	P3H2	316	Q8IVL5
VCYAKELKEGFVEYT	IPO5	686	O00410
FDLVICYKVGKFYEL	MSH6	421	P52701
VKQYFYETRCKEARP	NTF3	186	P20783
NEYKEGKLQAYRLIC	RALGAPA2	1006	Q2PPJ7
TKIIDCLEVEYYDKG	PRKG2	296	Q13237
YCYEVQLESKVRRKG	NAA40	136	Q86UY6
SELQKIYGKDKFYEC	PEG3	551	Q9GZU2
ILKVCGCDEYFLEKY	PIK3CA	251	P42336
ENVKRLLFCTGKVYY	OGDH	896	Q02218
DDIDKQYRKEAYRYC	KLHL11	621	Q9NVR0
RYEFGICVLDQKVYV	KLHL28	321	Q9NXS3
FKKCLAEYLSQEEYE	CARD14	851	Q9BXL6
YECDQGFYLLGEKKL	CR2	746	P20023
YELCKRFYLVVEAKD	FAT3	3301	Q8TDW7
KVTCRDLVEYFKAYI	ATL2	346	Q8NHH9
KYDAIYRGEEDLCKQ	CADPS2	206	Q86UW7
VKYECLAEEIKIGDY	DNAJC13	816	O75165
GIYRELCLESVKNKY	BRMS1L	121	Q5PSV4
RKDYEKICLKYGIVD	IGFN1	176	Q86VF2
YCDILYRDLKKGLEG	HELQ	846	Q8TDG4
CYEELLKYVGHIFRK	CACNA1H	456	O95180
VDCGKVKKRYYDRVT	DHX37	636	Q8IY37
FKQECKIKYSERVYE	PPP3CB	171	P16298
RGYCYVEFKEEKSAL	SART3	746	Q15020
LLVEKGEYCQTRYVK	RING1	271	Q06587
KVYQGLYCVAIRDFK	PSMD6	181	Q15008
YDFYQLLEEKCCGKL	SMG8	631	Q8ND04
KVETKKYDFYINVCG	IGF2R	651	P11717
VLVFEKILYKFCRDY	SLC4A7	671	Q9Y6M7
LQEKLYDIYVEECGK	SUPT20HL1	36	Q3ZLR7
YKVYADKRLDAQGRC	TMEM184B	316	Q9Y519
VAGYFKKYVDIFCLL	SAMD9	1296	Q5K651
FRCVKCDDKEYGIVY	PIK3C3	221	Q8NEB9
NFYFSIIKDRLYCEK	IARS2	796	Q9NSE4
KIKVCYVDYGFSENV	TDRD7	541	Q8NHU6
YDFEVEYLCDYKKIR	SUV39H1	41	O43463
LQEKLYDIYVEECGK	SUPT20HL2	36	P0C7V6
IYKGFCLDVIRNKYE	BRMS1	121	Q9HCU9
GEYVCKLILDIFEYE	ADGRF5	346	Q8IZF2
KRFNIVEEDTVLYCY	CNKSR2	401	Q8WXI2
VAYKRLIQEEYEGIC	ATP11A	611	P98196
RVKDYGCIVKFYNNV	PDCD11	551	Q14690
FQKVTLRRYGKCEYE	ZNF107	26	Q9UII5
KQKQELCEKFDYLYG	TRIM55	206	Q9BYV6
KECGKAYNRFYLLKE	ZNF778	676	Q96MU6
ERYEQICEFYSRAKK	ZNF618	706	Q5T7W0
VVCYDDRFIVKLAYE	ZC3H12A	221	Q5D1E8
RFKVFADYEDYIKCQ	PYGM	771	P11217
KKVLDFYQRACLSGY	TMEM94	731	Q12767
DFIEDYLKRVCKLYS	STX18	136	Q9P2W9
FKCYDVQLYKGIEDV	RFX8	221	Q6ZV50
VFQKLYDLYIEECEK	SUPT20H	36	Q8NEM7
KRYFECQAKYGAFVK	TBCB	211	Q99426
FDYKDQLKTGERCLY	PIK3CD	426	O00329
YCVKFIKGRAIKEYQ	SIRPD	116	Q9H106
YEKIYKEIECSIAGA	THOC7	81	Q6I9Y2
YECKECGKAFRLYLQ	ZNF780A	501	O75290
DKDCDVLVGYKAVYR	SERINC3	86	Q13530
LKVDCVERTGKYVYF	PHLDA2	56	Q53GA4
DVYGKVFNQKRYLAC	ZNF28	246	P17035
DKVVIVCKRKGYSYE	VAV2	431	P52735
REKEEERAKYIGCYL	WSCD2	121	Q2TBF2
LYIEVRCLKDYGEFE	GINS1	146	Q14691
KKYDVTVFQYIGELC	SLC27A6	301	Q9Y2P4
DLCLFYYRDEKEEGI	PLEKHA5	196	Q9HAU0
PYFQNKVIVKEYECR	TSPY26P	246	Q9H489
RFKVFADYEAYVKCQ	PYGL	771	P06737
KEEEAYFERCGYKIQ	PRPF18	36	Q99633
RCNILAIKIKYDEYE	XK	186	P51811
AELVNYERVKEYCLK	TTC9	141	Q92623
RGYYRLEVKAKDTCD	MYBPC2	131	Q14324