Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR2 ITPR3

1.40e-0431372GO:0005220
GeneOntologyMolecularFunctionRNA polymerase I core binding

RRN3P2 RRN3

2.78e-0441372GO:0001042
GeneOntologyMolecularFunctionSUMO binding

ZCCHC18 ZCCHC12 HERC2

2.82e-04191373GO:0032183
GeneOntologyMolecularFunctionproteasome binding

ECPAS PSME4 SACS

3.31e-04201373GO:0070628
GeneOntologyBiologicalProcessorganelle localization

VPS11 MYO1A MYO5A MYO5B SYNE1 KIFAP3 STX3 CEP120 MDN1 FHOD1 AP3B2 EXOC6B DNM3 ATM UXT CADPS2 DYNC1H1 HTT

1.10e-0670313818GO:0051640
GeneOntologyBiologicalProcessmaintenance of location in cell

CHERP MYO5A SYNE1 DZIP1 ITPR2 ITPR3 VPS13D ANKRD13C NOS1 HTT SORL1

1.40e-0625913811GO:0051651
GeneOntologyBiologicalProcesspositive regulation of cilium assembly

DZIP1 ASAP1 CEP120 WRAP73 HTT

3.44e-06351385GO:0045724
GeneOntologyBiologicalProcessestablishment of organelle localization

MYO5A MYO5B SYNE1 KIFAP3 CEP120 MDN1 FHOD1 AP3B2 EXOC6B DNM3 ATM UXT CADPS2 DYNC1H1 HTT

3.96e-0654613815GO:0051656
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

PLXNA3 SETX MYO5B KALRN RRN3P2 DZIP1 ASAP1 CEP120 UBE2V2 RRN3 WRAP73 DNM3 PLXNA1 HTT

5.95e-0649413814GO:0031346
GeneOntologyBiologicalProcessintracellular transport

VPS11 NUP107 MYO5A MYO5B ABCA12 SYNE1 XPO4 KIFAP3 MALT1 VPS13D STX3 IPO9 ADRB2 DST CEP120 MDN1 FHOD1 AP3B2 VPS41 EXOC6B UXT HERC2 DYNC1H1 HTT UEVLD SORL1

5.98e-06149613826GO:0046907
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

VPS11 HAUS6 MYO5B SYNE1 HJURP ARHGEF18 DZIP1 ASAP1 CEP120 SACS UBE2V2 FHOD1 VPS41 WRAP73 DNM3 SENP6 ATM DYNC1H1 TBCD HTT AMIGO2 SORL1

1.33e-05118913822GO:0044087
GeneOntologyBiologicalProcessprotein-containing complex localization

MYO5B KALRN SYNE1 DZIP1 KIFAP3 STX3 IPO9 MDN1 DNM3 ATM

1.83e-0527813810GO:0031503
GeneOntologyBiologicalProcessregulation of organelle assembly

VPS11 SYNE1 DZIP1 ASAP1 CEP120 WRAP73 SENP6 ATM DYNC1H1 HTT

1.94e-0528013810GO:1902115
GeneOntologyBiologicalProcessvesicle localization

MYO1A MYO5A MYO5B KIFAP3 AP3B2 EXOC6B DNM3 CADPS2 HTT

4.39e-052471389GO:0051648
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

4.44e-0521382GO:0021628
GeneOntologyBiologicalProcesspositive regulation of organelle assembly

DZIP1 ASAP1 CEP120 WRAP73 DYNC1H1 HTT

4.82e-05971386GO:1902117
GeneOntologyBiologicalProcessaxo-dendritic transport

MYO5A KIFAP3 DST AP3B2 DYNC1H1 HTT

5.11e-05981386GO:0008088
GeneOntologyBiologicalProcessmaintenance of location

CHERP MYO5A SYNE1 DZIP1 ITPR2 ITPR3 VPS13D ANKRD13C NOS1 HTT SORL1

7.40e-0539613811GO:0051235
GeneOntologyBiologicalProcessnuclear migration

SYNE1 CEP120 FHOD1 DYNC1H1

7.61e-05341384GO:0007097
GeneOntologyBiologicalProcessvesicle cytoskeletal trafficking

MYO5A MYO5B KIFAP3 AP3B2 HTT

8.63e-05671385GO:0099518
GeneOntologyBiologicalProcessregulation of cilium assembly

SYNE1 DZIP1 ASAP1 CEP120 WRAP73 HTT

8.80e-051081386GO:1902017
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

PLXNA3 SETX MYO5B KALRN SYNE1 RRN3P2 DZIP1 ASAP1 VPS13D ADRB2 CEP120 UBE2V2 RRN3 FHOD1 WRAP73 DNM3 ATM PLXNA1 DYNC1H1 HTT AMIGO2 PROS1

1.07e-04136613822GO:0051130
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CHERP MYO5A ITPR2 ITPR3 ADRB2 TRPM1 NOS1 HTT

1.09e-042171388GO:0097553
GeneOntologyBiologicalProcessolfactory nerve morphogenesis

PLXNA3 PLXNA1

1.33e-0431382GO:0021627
GeneOntologyBiologicalProcessestablishment of vesicle localization

MYO5A MYO5B KIFAP3 AP3B2 EXOC6B DNM3 CADPS2 HTT

1.35e-042241388GO:0051650
GeneOntologyBiologicalProcesscytoskeleton-dependent intracellular transport

MYO5A MYO5B KIFAP3 DST AP3B2 UXT DYNC1H1 HTT

1.39e-042251388GO:0030705
GeneOntologyBiologicalProcessmaintenance of protein location in cell

SYNE1 DZIP1 VPS13D ANKRD13C SORL1

1.57e-04761385GO:0032507
GeneOntologyBiologicalProcesspositive regulation of plasma membrane bounded cell projection assembly

DZIP1 ASAP1 CEP120 WRAP73 DNM3 HTT

1.80e-041231386GO:0120034
GeneOntologyBiologicalProcessnucleus localization

SYNE1 CEP120 FHOD1 DYNC1H1

2.12e-04441384GO:0051647
GeneOntologyBiologicalProcessmacroautophagy

RETREG2 MYO5A SESN3 SNX14 RAB33A VPS13D ADRB2 VPS41 ATM HTT

2.16e-0437413810GO:0016236
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

CFAP47 HAUS6 DZIP1 DDB1 FSIP2 DST CEP120 WRAP73 SENP6 UXT DYNC1H1 TBCD HTT WDR72

3.42e-0472013814GO:0000226
GeneOntologyBiologicalProcessprotein localization to organelle

VPS11 NUP107 KALRN SYNE1 SRP68 SRP72 PCARE DZIP1 ASAP1 FSIP2 VPS13D IPO9 ANKRD13C VPS41 PARP9 IK HTT SORL1

3.60e-04109113818GO:0033365
GeneOntologyBiologicalProcesstransport along microtubule

MYO5A KIFAP3 DST AP3B2 UXT DYNC1H1 HTT

3.68e-041971387GO:0010970
GeneOntologyBiologicalProcessregulation of mini excitatory postsynaptic potential

SYNE1 ADRB2

4.39e-0451382GO:0061884
GeneOntologyBiologicalProcessprotein retention in Golgi apparatus

VPS13D SORL1

4.39e-0451382GO:0045053
GeneOntologyBiologicalProcessmini excitatory postsynaptic potential

SYNE1 ADRB2

4.39e-0451382GO:0098816
GeneOntologyBiologicalProcesspositive regulation of lipophagy

ADRB2 HTT

4.39e-0451382GO:1904504
GeneOntologyBiologicalProcessregulation of lipophagy

ADRB2 HTT

4.39e-0451382GO:1904502
GeneOntologyBiologicalProcessintracellular protein transport

VPS11 NUP107 MYO5A MYO5B ABCA12 XPO4 VPS13D STX3 IPO9 AP3B2 VPS41 EXOC6B HERC2 SORL1

4.49e-0474013814GO:0006886
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

CHERP MYO5A ITPR2 ITPR3 NOS1 HTT

4.53e-041461386GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

CHERP MYO5A ITPR2 ITPR3 NOS1 HTT

4.70e-041471386GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

CHERP MYO5A ITPR2 ITPR3 NOS1 HTT

5.05e-041491386GO:0051282
GeneOntologyBiologicalProcesspositive regulation of cellular component biogenesis

MYO5B DZIP1 ASAP1 CEP120 UBE2V2 FHOD1 WRAP73 DNM3 ATM DYNC1H1 HTT AMIGO2

5.49e-0458213812GO:0044089
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

PLXNA3 SETX MYO5B KALRN SYNE1 RRN3P2 DZIP1 ASAP1 CEP120 UBE2V2 RRN3 WRAP73 DNM3 PLXNA1 HTT

5.51e-0484613815GO:0120035
GeneOntologyBiologicalProcesssequestering of calcium ion

CHERP MYO5A ITPR2 ITPR3 NOS1 HTT

5.80e-041531386GO:0051208
GeneOntologyBiologicalProcessregulation of cell projection organization

PLXNA3 SETX MYO5B KALRN SYNE1 RRN3P2 DZIP1 ASAP1 CEP120 UBE2V2 RRN3 WRAP73 DNM3 PLXNA1 HTT

6.76e-0486313815GO:0031344
GeneOntologyBiologicalProcessmicrotubule-based process

CFAP47 HAUS6 MYO5A DZIP1 DDB1 FSIP2 KIFAP3 DST CEP120 AP3B2 WRAP73 SENP6 UXT DYNC1H1 TBCD HTT WDR72

7.13e-04105813817GO:0007017
GeneOntologyBiologicalProcessneuron development

SLC25A46 PLXNA3 SETX RPS6KA5 MYO5B KALRN SYNE1 LAMA2 RRN3P2 PCARE ASAP1 POSTN STX3 DST UBE2V2 RRN3 DNM3 TRPM1 PLXNA1 TBCD HTT

7.24e-04146313821GO:0048666
GeneOntologyCellularComponentphotoreceptor inner segment

PCARE KIFAP3 STX3 GUCA1B DNM3 NOS1

1.24e-05781376GO:0001917
GeneOntologyCellularComponentintracellular protein-containing complex

UBR2 FBXL13 PRAMEF5 SESN3 DZIP1 REV3L ECPAS DDB1 CNOT8 MALT1 ZZZ3 PSME4 UBE2V2 DDA1 CNOT7 UXT FBXO32 PRAMEF6 NAA16

1.96e-0597213719GO:0140535
GeneOntologyCellularComponentAP-3 adaptor complex

VPS11 AP3B2 VPS41

7.51e-05131373GO:0030123
GeneOntologyCellularComponentsomatodendritic compartment

MYO1A MYO5A MYO5B KALRN SYNE1 LAMA2 ASAP1 ITPR3 SNX14 STX3 ADRB2 SACS DNM3 CCR1 TRPM1 NOS1 DYNC1H1 HTT HDAC1 SORL1

1.49e-04122813720GO:0036477
GeneOntologyCellularComponentCCR4-NOT core complex

CNOT8 CNOT7

6.29e-0461372GO:0030015
GeneOntologyCellularComponentaxon

SETX MYO1A MYO5A ITPR2 STX3 ADRB2 DST SACS AP3B2 DNM3 TRPM1 NOS1 DYNC1H1 UNC80 HTT

7.57e-0489113715GO:0030424
GeneOntologyCellularComponentphotoreceptor outer segment

MYO5A PCARE KIFAP3 STX3 GUCA1B

8.26e-041111375GO:0001750
GeneOntologyCellularComponentpostsynapse

MYO5A MYO5B KALRN SYNE1 LAMA2 ASAP1 KIFAP3 SNX14 STX3 ADRB2 DST DNM3 SENP6 CADPS2 NOS1 HTT

1.04e-03101813716GO:0098794
GeneOntologyCellularComponentdendritic spine

MYO5B SYNE1 LAMA2 ASAP1 ADRB2 DNM3 NOS1

1.10e-032421377GO:0043197
GeneOntologyCellularComponentneuron spine

MYO5B SYNE1 LAMA2 ASAP1 ADRB2 DNM3 NOS1

1.24e-032471377GO:0044309
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR2 ITPR3

1.49e-0391372GO:0031095
GeneOntologyCellularComponentdendrite

MYO5A MYO5B SYNE1 LAMA2 ASAP1 ITPR3 SNX14 STX3 ADRB2 SACS DNM3 TRPM1 NOS1 HTT

1.53e-0385813714GO:0030425
GeneOntologyCellularComponentdendritic tree

MYO5A MYO5B SYNE1 LAMA2 ASAP1 ITPR3 SNX14 STX3 ADRB2 SACS DNM3 TRPM1 NOS1 HTT

1.56e-0386013714GO:0097447
MousePhenoabnormal Purkinje cell dendrite morphology

SLC25A46 MYO5A SACS ATM HERC2 CADPS2

5.70e-06581096MP:0008572
MousePhenoabnormal neurite morphology

SLC25A46 RPS6KA5 MYO5A KALRN ECPAS ADGRG6 DST SACS LTN1 ATM HERC2 CADPS2 NOS1 HTT

8.39e-0644210914MP:0008415
MousePhenoimpaired limb coordination

MYO5A ADGRG6 DST DYNC1H1 HTT

9.41e-05591095MP:0001524
MousePhenoabnormal neuromuscular synapse morphology

SLC25A46 SETX KALRN SYNE1 DST DYNC1H1

9.69e-05951096MP:0001053
MousePhenoabnormal dendrite morphology

SLC25A46 RPS6KA5 MYO5A KALRN SACS ATM HERC2 CADPS2 NOS1

9.73e-052371099MP:0008143
MousePhenoabnormal somatic motor system morphology

SLC25A46 SETX KALRN SYNE1 DST DYNC1H1

1.15e-04981096MP:0001051
DomainARM-type_fold

VPS11 XPO4 ECPAS VIRMA ITPR2 KIFAP3 IPO9 PSME4 FHOD1 AP3B2 LTN1 MROH7 ATM TBCD HTT

2.42e-0833913515IPR016024
DomainARM-like

SETX XPO4 ECPAS KIFAP3 IPO9 PSME4 FHOD1 AP3B2 LTN1 MROH7 TBCD HTT

6.24e-0727013512IPR011989
Domain-

XPO4 ECPAS KIFAP3 IPO9 PSME4 FHOD1 AP3B2 MROH7 TBCD HTT

4.96e-06222135101.25.10.10
DomainRNaseH-like_dom

GIN1 REV3L ZBED5 CNOT8 CNOT7

1.42e-04691355IPR012337
DomainHEAT_REPEAT

ECPAS PSME4 MROH7 TBCD HTT

1.52e-04701355PS50077
DomainInsP3_rcpt-bd

ITPR2 ITPR3

1.55e-0431352IPR000493
Domain-

GIN1 REV3L CNOT8 CNOT7

3.66e-044713543.30.420.10
DomainMyosin_S1_N

MYO5A MYO5B

5.11e-0451352IPR008989
DomainRNase_CAF1

CNOT8 CNOT7

5.11e-0451352IPR006941
DomainCAF1

CNOT8 CNOT7

5.11e-0451352PF04857
DomainSpectrin

KALRN SYNE1 DST

5.88e-04231353PF00435
DomainWGR_domain

LAMA2 PARP16 PARP9

6.69e-04241353IPR008893
DomainRIH_assoc-dom

ITPR2 ITPR3

7.63e-0461352IPR013662
DomainDilute_dom

MYO5A MYO5B

7.63e-0461352IPR002710
DomainIns145_P3_rec

ITPR2 ITPR3

7.63e-0461352PF08709
DomainDIL

MYO5A MYO5B

7.63e-0461352PF01843
DomainRIH_assoc

ITPR2 ITPR3

7.63e-0461352PF08454
DomainRIH_dom

ITPR2 ITPR3

7.63e-0461352IPR000699
DomainIns145_P3_rcpt

ITPR2 ITPR3

7.63e-0461352IPR014821
DomainRyanodine_recept-rel

ITPR2 ITPR3

7.63e-0461352IPR015925
Domain-

ITPR2 ITPR3

7.63e-04613521.25.10.30
DomainDILUTE

MYO5A MYO5B

7.63e-0461352PS51126
DomainRYDR_ITPR

ITPR2 ITPR3

7.63e-0461352PF01365
DomainDIL

MYO5A MYO5B

7.63e-0461352SM01132
Domain-

VPS11 SRP68 SRP72 TEX11 VPS41 UTY NAA16

7.77e-0420713571.25.40.10
Domain-

ZCCHC18 ZCCHC12 RTL3

8.50e-042613534.10.60.10
DomainClathrin

VPS11 VPS41

1.06e-0371352PF00637
DomainCHCR

VPS11 VPS41

1.06e-0371352PS50236
DomainSpectrin_repeat

KALRN SYNE1 DST

1.18e-03291353IPR002017
DomainClathrin_H-chain/VPS_repeat

VPS11 VPS41

1.41e-0381352IPR000547
DomainTPR-like_helical_dom

VPS11 SRP68 SRP72 TEX11 VPS41 UTY NAA16

1.54e-032331357IPR011990
DomainSPEC

KALRN SYNE1 DST

1.57e-03321353SM00150
DomainSpectrin/alpha-actinin

KALRN SYNE1 DST

1.57e-03321353IPR018159
DomainPlexin_cytopl

PLXNA3 PLXNA1

1.81e-0391352PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1

1.81e-0391352IPR013548
DomainPlexin

PLXNA3 PLXNA1

1.81e-0391352IPR031148
DomainZF_CCHC

ZCCHC18 ZCCHC12 RTL3

2.04e-03351353PS50158
DomainMIR

ITPR2 ITPR3

2.25e-03101352PF02815
DomainMIR_motif

ITPR2 ITPR3

2.25e-03101352IPR016093
DomainMIR

ITPR2 ITPR3

2.25e-03101352PS50919
DomainMIR

ITPR2 ITPR3

2.25e-03101352SM00472
DomainFlavoprot_Pyr_Nucl_cyt_Rdtase

NOS1 CYB5R2

2.25e-03101352IPR001709
DomainMyosin_head_motor_dom

MYO1A MYO5A MYO5B

2.59e-03381353IPR001609
DomainMYOSIN_MOTOR

MYO1A MYO5A MYO5B

2.59e-03381353PS51456
DomainMyosin_head

MYO1A MYO5A MYO5B

2.59e-03381353PF00063
DomainMYSc

MYO1A MYO5A MYO5B

2.59e-03381353SM00242
DomainPNMA

ZCCHC18 ZCCHC12

2.73e-03111352IPR026523
DomainLaminin_G_1

LAMA2 PROS1

2.73e-03111352PF00054
DomainPNMA

ZCCHC18 ZCCHC12

2.73e-03111352PF14893
DomainOxRdtase_FAD/NAD-bd

NOS1 CYB5R2

3.26e-03121352IPR001433
DomainNAD_binding_1

NOS1 CYB5R2

3.26e-03121352PF00175
DomainATPase_dyneun-rel_AAA

MDN1 DYNC1H1

4.46e-03141352IPR011704
DomainAAA_5

MDN1 DYNC1H1

4.46e-03141352PF07728
DomainHEAT

ECPAS TBCD HTT

5.04e-03481353PF02985
DomainPoly(ADP-ribose)pol_cat_dom

PARP16 PARP9

6.57e-03171352IPR012317
DomainPARP_CATALYTIC

PARP16 PARP9

6.57e-03171352PS51059
DomainPARP

PARP16 PARP9

6.57e-03171352PF00644
Domain-

PARP16 PARP9

6.57e-031713523.90.228.10
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CHERP ACACA NUP107 MYO5A SRP68 SRP72 ECPAS VIRMA DDB1 ITPR3 DST MDN1 ATM HERC2 IK DYNC1H1

8.90e-096531391622586326
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CFAP47 SETX ACACA SRP68 PCARE SAMHD1 LRRC70 REV3L ECPAS ITPR2 ZZZ3 DST MDN1 ATM DYNC1H1 HDAC1

4.66e-087361391629676528
Pubmed

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.

RRN3P2 RRN3 HTT

6.25e-083139334880223
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

HAUS6 NUP107 MYO5B XPO4 SRP68 PCARE CCDC51 POSTN KIFAP3 IPO9 CEP120 UBE2V2 DDA1 CNOT7 EXOC6B TFB2M UXT DYNC1H1 TBCD HDAC1 SORL1

7.11e-0813211392127173435
Pubmed

Hereditary Ataxia Overview

SLC25A46 SETX SYNE1 SNX14 VPS13D SACS ATM

9.23e-0892139720301317
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

SAMHD1 MDN1 FHOD1 LTN1 ATM TBCD HTT

2.15e-07104139731240132
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ACACA NUP107 MYO5A ECPAS ITPR3 LTN1 MROH7 HERC2

1.66e-06202139833005030
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

UBR2 ACACA SRP68 ITPR2 DST PSME4 LTN1 HERC2

2.37e-06212139833853758
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

HAUS6 NUP107 ECPAS DDB1 IPO9 CEP120 CNOT7 LTN1 IK DYNC1H1 TBCD HDAC1

2.82e-065601391235241646
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

FBXL13 PRAMEF5 MYO5A DDB1 ZBED5 VPS13D IPO9 PSME4 FHOD1 LTN1 EXOC6B PRAMEF6

3.04e-065641391221565611
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SYNE1 DST SACS LTN1 SIK2 SENP6

3.39e-0610113969872452
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

HAUS6 CHERP RETREG2 NUP107 SYNE1 HJURP DDB1 CNOT8 CEP120 DDA1 CNOT7 WRAP73 ATM HERC2 DYNC1H1 TBCD NAA16

3.93e-0611551391720360068
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

LURAP1 ZCCHC12 MYO5A KALRN SYNE1 SESN3 DZIP1 REV3L ZBED5 CNOT8 DST SACS DNM3 SENP6 ATM HERC2 CADPS2 DYNC1H1

3.96e-0612851391835914814
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

SETX CHERP NUP107 SRP68 SRP72 DDB1 IPO9 MDN1 FHOD1 ATM IK DYNC1H1

4.18e-065821391220467437
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

NLRP11 MYO5A SYNE1 PCARE VIRMA DST MDN1 UTY

4.92e-06234139836243803
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

UBR2 NUP107 MYO5A MYO5B XPO4 ASAP1 ITPR2 ITPR3 POSTN CNNM3 IPO9 LTN1 UXT UTP3 HERC2 IK

4.94e-0610491391627880917
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

SETX NUP107 DDB1 RRN3 PARP16 LTN1 HERC2 TOP1MT

7.98e-06250139833536335
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PLXNA3 ACACA KALRN REV3L ITPR2 ITPR3 DST MDN1 PSME4 HERC2 PLXNA1 DYNC1H1 CYB5R2 TBCD HTT BAHCC1

9.45e-0611051391635748872
Pubmed

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

RRN3P2 RRN3

1.59e-052139212015311
Pubmed

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.

KALRN HTT

1.59e-052139229789657
Pubmed

Identification of proteins that interact with murine cytomegalovirus early protein M112-113 in brain.

ZCCHC18 ZCCHC12

1.59e-052139222340173
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

1.59e-05213929065779
Pubmed

Conservation of the deadenylase activity of proteins of the Caf1 family in human.

CNOT8 CNOT7

1.59e-052139215769875
Pubmed

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

ATM HTT

1.59e-052139225540325
Pubmed

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

RPS6KA5 HTT

1.59e-052139218029446
Pubmed

A neuroprotective phase precedes striatal degeneration upon nucleolar stress.

RRN3P2 RRN3

1.59e-052139223764776
Pubmed

Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase.

DDB1 DDA1

1.59e-052139230564455
Pubmed

Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.

SRP68 SRP72

1.59e-052139228369529
Pubmed

Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.

SRP68 SRP72

1.59e-052139216672232
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.59e-05213928081734
Pubmed

Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.

KALRN HTT

1.59e-05213929285789
Pubmed

Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.

RRN3P2 RRN3

1.59e-052139238745938
Pubmed

TBCD may be a causal gene in progressive neurodegenerative encephalopathy with atypical infantile spinal muscular atrophy.

TBCD BAHCC1

1.59e-052139227928163
Pubmed

Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter.

RRN3P2 RRN3

1.59e-05213928413268
Pubmed

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.

ATM HTT

1.59e-052139228017939
Pubmed

Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.

RRN3P2 RRN3

1.59e-052139230918302
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

1.59e-052139215632133
Pubmed

Blended phenotype of combination of HERC2 and AP3B2 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15.

AP3B2 HERC2

1.59e-052139234042275
Pubmed

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.

IL12RB2 HTT

1.59e-05213928401589
Pubmed

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.

RRN3P2 RRN3

1.59e-052139227257073
Pubmed

Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.

ATM HTT

1.59e-052139224277524
Pubmed

ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

RRN3P2 RRN3

1.59e-052139212620228
Pubmed

Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis.

ECPAS PSME4

1.59e-052139237189334
Pubmed

Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase.

ATM HDAC1

1.59e-052139210531300
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

1.59e-052139217496801
Pubmed

Protein-induced conformational changes of RNA during the assembly of human signal recognition particle.

SRP68 SRP72

1.59e-052139217254600
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

1.59e-052139224901844
Pubmed

Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA.

SRP68 SRP72

1.59e-05213928388879
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

1.59e-052139233854148
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

1.59e-052139219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

1.59e-05213928063813
Pubmed

The Signal Recognition Particle Database (SRPDB).

SRP68 SRP72

1.59e-05213929399828
Pubmed

CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.

CNOT8 CNOT7

1.59e-052139235248544
Pubmed

Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.

RRN3P2 RRN3

1.59e-052139231110473
Pubmed

The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

CNOT8 CNOT7

1.59e-052139219605561
Pubmed

DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.

RRN3P2 RRN3

1.59e-052139223393135
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

1.59e-052139216195467
Pubmed

Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.

RRN3P2 RRN3

1.59e-052139224273493
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

1.59e-052139215713744
Pubmed

Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.

ADRB2 PLXNA1

1.59e-052139238331165
Pubmed

The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211.

LAMA2 ADGRG6

1.59e-052139225695270
Pubmed

The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.

PSME4 HTT

1.59e-052139233233776
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CHERP NUP107 MYO5A MYO5B SYNE1 DDB1 ITPR2 ITPR3 CNNM3 DST MDN1 SACS HERC2 IK DYNC1H1

1.60e-0510241391524711643
Pubmed

Defining the membrane proteome of NK cells.

CHERP NUP107 MYO5A TTPAL ECPAS ITPR2 ITPR3 CNNM3 IPO9 MDN1 PARP16 FHOD1 CNOT7 PARP9 HERC2 DYNC1H1

1.86e-0511681391619946888
Pubmed

Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

MYO1A MYO5A MYO5B

2.20e-051413938022818
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SETX ACACA NUP107 MYO5A SRP68 DDB1 ZBED5 ASAP1 IPO9 DST MDN1 PSME4 FHOD1 LTN1 HERC2 IK DYNC1H1

3.01e-0513531391729467282
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

KALRN SYNE1 LAMA2 SRP68 SRP72 SAMHD1 DZIP1 ASAP1 DST FBXO32

3.34e-054971391023414517
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

INTS6L KALRN SYNE1 KIFAP3 DST DYNC1H1

3.39e-05151139617043677
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

CHERP MYO5B SAMHD1 VIRMA MDN1 SACS FHOD1 TFB2M TBCD

3.54e-05400139935013556
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

VPS11 CHERP MYO5A IPO9 LTN1 ATM HERC2 IK

3.99e-05313139838270169
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

MYO5A MYO5B SRP68 SRP72 VIRMA DDB1 ITPR2 ITPR3 DST FHOD1 TFB2M UTP3 IK PATJ DYNC1H1 HDAC1

4.50e-0512571391636526897
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR2 ITPR3

4.75e-053139210874040
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR2 ITPR3

4.75e-053139220395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR2 ITPR3

4.75e-053139217437169
Pubmed

Human Rab small GTPase- and class V myosin-mediated membrane tethering in a chemically defined reconstitution system.

MYO5A MYO5B

4.75e-053139228939769
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR2 ITPR3

4.75e-053139218547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR2 ITPR3

4.75e-053139236350267
Pubmed

The versatility and universality of calcium signalling.

ITPR2 ITPR3

4.75e-053139211413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

4.75e-053139226009177
Pubmed

Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration.

HDAC1 PROS1

4.75e-053139236951067
Pubmed

Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.

SAMHD1 DDB1

4.75e-053139228202763
Pubmed

Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes.

MYO5A MYO5B

4.75e-053139224508725
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR2 ITPR3

4.75e-05313921693919
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR2 ITPR3

4.75e-053139223955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR2 ITPR3

4.75e-053139231979185
Pubmed

Structural basis of lentiviral subversion of a cellular protein degradation pathway.

SAMHD1 DDB1

4.75e-053139224336198
Pubmed

A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.

SRP68 SRP72

4.75e-053139223048028
Pubmed

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.

CNOT8 CNOT7

4.75e-053139237767629
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR2 ITPR3

4.75e-053139224904548
Pubmed

Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.

MYO5A MYO5B

4.75e-053139224339992
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR2 ITPR3

4.75e-05313929858485
Pubmed

Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.

CNOT8 CNOT7

4.75e-053139233021411
Pubmed

Histone deacetylase regulation of ATM-mediated DNA damage signaling.

ATM HDAC1

4.75e-053139223939379
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

4.75e-053139221435446
Pubmed

A novel form of capsaicin-modified amygdala LTD mediated by TRPM1.

TRPM1 NOS1

4.75e-053139227633915
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR2 ITPR3

4.75e-05313929808793
Pubmed

Identification of plexin family molecules in mice.

PLXNA3 PLXNA1

4.75e-05313928806646
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR2 ITPR3

4.75e-053139218194433
Pubmed

TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.

RRN3P2 RRN3

4.75e-053139219217408
Pubmed

The temporal and spatial expression pattern of myosin Va, Vb and VI in the mouse ovary.

MYO5A MYO5B

4.75e-053139216713372
InteractionGPR17 interactions

SLC25A46 SETX RETREG2 XPO4 ECPAS ITPR2 MDN1 SACS LTN1 ATM TBCD HTT

3.64e-0728313212int:GPR17
InteractionNPTN interactions

SETX XPO4 ECPAS MDN1 RRN3 FHOD1 LTN1 ATM TFB2M TBCD HTT

2.24e-0627813211int:NPTN
InteractionZDBF2 interactions

LURAP1 ACACA VIRMA SENP6 IK HDAC1

3.21e-06621326int:ZDBF2
InteractionMRFAP1L1 interactions

INTS6L LURAP1 TEX11 CNOT7 HERC2 IK HTT

9.02e-061121327int:MRFAP1L1
InteractionC3orf18 interactions

VPS11 XPO4 ECPAS MDN1 SACS LTN1 EXOC6B

1.07e-051151327int:C3orf18
InteractionSIRT7 interactions

CHERP ACACA NUP107 MYO5A SRP68 SRP72 ECPAS VIRMA DDB1 ITPR3 DST MDN1 ATM HERC2 IK DYNC1H1

2.96e-0574413216int:SIRT7
InteractionPSMD2 interactions

ACACA SAMHD1 ECPAS VIRMA IPO9 ADRB2 PSME4 WRAP73 FBXO32 HERC2 HTT HDAC1

2.97e-0543513212int:PSMD2
InteractionZNF827 interactions

CHERP VIRMA UNC80 HDAC1

3.68e-05291324int:ZNF827
InteractionSCN2B interactions

XPO4 MDN1 EXOC6B DNM3 ATM TBCD

3.80e-05951326int:SCN2B
InteractionAXDND1 interactions

SYNE1 SRP68 SRP72

4.36e-05111323int:AXDND1
InteractionLRRC31 interactions

ACACA NUP107 MYO5A ECPAS ITPR3 LTN1 MROH7 HERC2

6.27e-052051328int:LRRC31
InteractionCTDP1 interactions

SAMHD1 VIRMA MDN1 FHOD1 LTN1 ATM TBCD HTT

6.71e-052071328int:CTDP1
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR2 ITPR3

8.34e-053962297
GeneFamilyMyosins, class V

MYO5A MYO5B

8.34e-0539621100
GeneFamilyZinc fingers CCHC-type|RNA binding motif containing

ZCCHC18 ZCCHC12 RTL3

3.07e-042596374
GeneFamilyPlexins

PLXNA3 PLXNA1

9.80e-049962683
GeneFamilyParaneoplastic Ma antigens

ZCCHC18 ZCCHC12

1.49e-0311962671
GeneFamilyCCR4-NOT transcription complex

CNOT8 CNOT7

1.49e-03119621023
GeneFamilyGla domain containing

POSTN PROS1

2.09e-03139621250
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP16 PARP9

3.60e-0317962684
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

ZZZ3 HERC2

4.04e-031896291
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

INTS6L UBR2 VPS11 HAUS6 SETX RPS6KA5 MYO5A SYNE1 SESN3 XPO4 REV3L ZBED5 ASAP1 ITPR2 MALT1 SACS FHOD1 SENP6 PARP9 ATM IK DYNC1H1 TBCD SORL1

8.05e-07149213724M40023
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

SLC25A46 UBR2 VPS11 SETX ACACA RETREG2 ECPAS ITPR2 MALT1 ADRB2 MDN1 SACS RRN3 LTN1 VPS41 SENP6 CCR1 ATM DYNC1H1 AMIGO2 UEVLD

1.40e-06121513721M41122
CoexpressionGSE6674_ANTI_IGM_VS_CPG_STIM_BCELL_UP

RETREG2 RPS6KA5 ARHGEF18 DZIP1 ASAP1 CEP120 FBXO32 UEVLD

1.08e-052001378M6927
CoexpressionGSE7568_CTRL_VS_3H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN

HAUS6 ECPAS CNNM3 PSME4 ANKRD13C PLXNA1 NAA16

2.89e-051671377M361
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

HAUS6 SETX MYO5A DZIP1 REV3L ITPR2 ZZZ3 SACS VPS41 TRPM1 ATM PROS1 SORL1

4.20e-0565613713M18979
CoexpressionGSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP

SYNE1 SESN3 ARHGEF18 VPS13D PSME4 ATM HERC2

5.35e-051841377M9005
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

PLXNA3 PRAMEF5 MYO5B KALRN SYNE1 SESN3 DZIP1 ECPAS ASAP1 ITPR2 DST DNM3 FBXO32 PRAMEF6 HTT PROS1 SORL1

8.21e-05112413717MM1070
CoexpressionGSE10273_HIGH_VS_LOW_IL7_TREATED_IRF4_8_NULL_PRE_BCELL_DN

INTS6L SETX ITPR2 ITPR3 VPS13D HERC2 DYNC1H1

8.75e-051991377M316
CoexpressionGSE15330_WT_VS_IKAROS_KO_HSC_DN

MYO5A SYNE1 KIFAP3 SNX14 DYNC1H1 TBCD HDAC1

8.75e-051991377M7036
CoexpressionGSE40277_GATA1_AND_SATB1_TRANSDUCED_VS_CTRL_CD4_TCELL_DN

ZCCHC12 DZIP1 ZZZ3 IPO9 CNOT7 SENP6 HDAC1

8.75e-051991377M9178
CoexpressionGSE6674_ANTI_IGM_VS_ANTI_IGM_AND_CPG_STIM_BCELL_UP

ARHGEF18 SAMHD1 DZIP1 ASAP1 CEP120 PARP9 IK

8.75e-051991377M6934
CoexpressionLAKE_ADULT_KIDNEY_C28_INTERSTITIUM

KALRN SYNE1 LAMA2 REV3L DST

8.99e-05861375M39247
CoexpressionGSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_ATOPIC_PATIENT_UP

ECPAS DDB1 KIFAP3 SACS WRAP73 UTP3 HDAC1

9.03e-052001377M7077
CoexpressionGSE21670_UNTREATED_VS_IL6_TREATED_CD4_TCELL_DN

SYNE1 SESN3 ASAP1 ITPR3 VPS13D PARP16 SENP6

9.03e-052001377M7441
CoexpressionGSE40273_GATA1_KO_VS_WT_TREG_DN

SYNE1 SESN3 ARHGEF18 ITPR2 MALT1 VPS41 HDAC1

9.03e-052001377M9133
CoexpressionGSE10500_ARTHRITIC_SYNOVIAL_FLUID_VS_HEALTHY_MACROPHAGE_DN

ITPR2 SNX14 DST EXOC6B TFB2M DYNC1H1

1.17e-041451376M359
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 KALRN SYNE1 LAMA2 SAMHD1 ASAP1 MDN1

2.18e-0619013871121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 KALRN SYNE1 LAMA2 SAMHD1 ASAP1 MDN1

2.18e-061901387048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

KALRN SYNE1 ASAP1 ADGRL4 ADGRG6 POSTN CADPS2

2.26e-061911387c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

KALRN SYNE1 ASAP1 ADGRL4 POSTN CADPS2 TBCD

2.77e-061971387ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

KALRN SYNE1 ASAP1 ADGRL4 DNM3 CADPS2 TBCD

2.77e-061971387f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 KALRN SYNE1 LAMA2 SAMHD1 ASAP1 MDN1

2.86e-061981387a860246bcea847249a78fd2e86ed8e04371060db
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN DST FBXO32

2.96e-061991387e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANO4 LAMA2 DZIP1 ADGRG6 POSTN DST FBXO32

2.96e-06199138738cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 LAMA2 DZIP1 ADGRG6 POSTN FBXO32

3.06e-062001387f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 LAMA2 DZIP1 ADGRG6 POSTN FBXO32

3.06e-0620013875ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN DST FBXO32

3.06e-062001387c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN DST FBXO32

3.06e-06200138708bf8c00eee6468215edb3611296bfc8784c4d56
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 LAMA2 DZIP1 ADGRG6 POSTN FBXO32

3.06e-06200138767dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN DST FBXO32

3.06e-06200138702cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN DST FBXO32

3.06e-062001387dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 LAMA2 DZIP1 ADGRG6 POSTN FBXO32

3.06e-0620013878bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 LAMA2 DZIP1 ADGRG6 POSTN FBXO32

3.06e-06200138777631c471cc5d453a749784f838cfa6408caf09b
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

INTS6L SETX RETREG2 ARHGEF18 VIRMA SORL1

8.96e-0615513860a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

INTS6L SETX ARHGEF18 ZZZ3 MDN1 PATJ

1.37e-051671386948504367ecf58144d9dd74d2ec531358fc4b309
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

KALRN ABCA12 SYNE1 ADGRL4 ADGRG6 TMEM26

1.57e-051711386bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

IL12RB2 KALRN DST SIK2 UTY HTT

1.84e-0517613863de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

IL12RB2 KALRN DST SIK2 UTY HTT

1.90e-05177138682fdd6185b368f54f03de389427cbe3071d21a99
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

SYNE1 VPS13D DST MDN1 DNM3 DYNC1H1

1.90e-051771386e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZCCHC12 SESN3 ATM UXT FBXO32 SORL1

1.97e-05178138673936c2e7e8855b4ab65cad425686513dba331a3
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|368C / Donor, Lineage, Cell class and subclass (all cells)

IL12RB2 VPS11 RAB33A CEP120 SENP6 PATJ

2.16e-051811386b193f3606554adc55c5906219d114288bb1f978a
ToppCellCOVID-19-Epithelial-Ionocytes|Epithelial / Condition, Lineage and Cell class

INTS6L FRMPD1 ITPR2 POSTN SORL1 WDR72

2.16e-0518113864a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCellCOVID-19_Mild-CD4+_T_activated|COVID-19_Mild / Disease condition and Cell class

ECPAS VIRMA ZZZ3 DST PARP9 PATJ

2.23e-051821386877b6e611626628e709568747512f2827ebb2795
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

KALRN ADGRL4 ADGRG6 DNM3 CADPS2 NOS1

2.67e-051881386d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

ANO4 LAMA2 DZIP1 ADGRG6 POSTN UNC80

2.75e-05189138644e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

ASAP1 ADGRL4 ADGRG6 ITPR2 POSTN CADPS2

2.75e-051891386c81787a8c662db5d7814c583dd64562857629e81
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

KALRN ADGRL4 ADGRG6 DNM3 CADPS2 TBCD

2.84e-05190138678e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO4 DZIP1 ADGRG6 POSTN FBXO32 UNC80

3.01e-05192138672881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCelldroplet-Lung-30m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRL4 ADGRG6 DST DNM3 CADPS2 AMIGO2

3.01e-051921386452d54f0aca8657722d7ac61e8422921d08c06b3
ToppCelldroplet-Lung-30m-Endothelial-venous_endothelial-vein_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRL4 ADGRG6 DST DNM3 CADPS2 AMIGO2

3.01e-0519213867ddaca206599603d4d0b2afb73ed2850225d277d
ToppCelldroplet-Lung-30m-Endothelial-venous_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRL4 ADGRG6 DST DNM3 CADPS2 AMIGO2

3.01e-051921386bf0b996aeedc34a79c71df3379ec9c1aabe06a8c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN SYNE1 ASAP1 ADGRL4 DNM3 TBCD

3.19e-051941386a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SESN3 SAMHD1 ATM FBXO32 PATJ SORL1

3.19e-051941386a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

KALRN SYNE1 ASAP1 ADGRL4 CADPS2 TBCD

3.28e-051951386fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

KALRN SYNE1 ADGRL4 DNM3 CADPS2 TBCD

3.28e-05195138619e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REV3L DDB1 DST UTY DYNC1H1 UNC80

3.28e-0519513867796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN SYNE1 ASAP1 ADGRL4 DNM3 TBCD

3.57e-0519813861378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN SYNE1 ASAP1 ADGRL4 DNM3 TBCD

3.57e-051981386451003a21162eeae90739fdb502bb50b362d80c8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN SYNE1 ASAP1 ADGRL4 DNM3 TBCD

3.57e-051981386440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

UBR2 ACACA ITPR2 EXOC6B CADPS2 UTY

3.67e-05199138694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN FBXO32

3.67e-0519913866b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN FBXO32

3.78e-0520013869d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 DZIP1 ADGRG6 POSTN FBXO32

3.78e-05200138687827041663013f5e7273168dc8709d69840e7ce
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

UBR2 SETX SAMHD1 PARP9 ATM DYNC1H1

3.78e-05200138612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANO4 LAMA2 DZIP1 ADGRG6 POSTN FBXO32

3.78e-05200138609537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

ANO4 SYNE1 ADGRG6 POSTN DST FBXO32

3.78e-052001386593bf6a7c557437db9a9249a5058a46014179ef6
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

ANO4 LAMA2 DZIP1 ADGRG6 POSTN FBXO32

3.78e-052001386a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO4 LURAP1 FRMPD1 FBXO32 TMEM26

4.08e-05123138587401764a073c1808f214642a9c84299c78f7ec7
ToppCellControl-B_intermediate-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

INTS6L SETX ARHGEF18 ZZZ3 PATJ

8.63e-051441385984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

KALRN ADGRL4 POSTN NOS1 UNC80

1.05e-0415013854f31867cb85253ff6d22f3b02ef972a42cb41123
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UBR2 SETX KALRN TOP1MT SORL1

1.08e-041511385b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 CAMP SLC22A6 CCR1 SORL1

1.08e-041511385ced4f7ee377a23a804ae6fde624e8b55b79f1fd8
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 CAMP SLC22A6 CCR1 SORL1

1.08e-041511385b52bb3b88e9a6473f571053537b8beb418678539
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KALRN ADGRL4 OR6C75 DNM3 TBCD

1.26e-041561385f894fac4e44a23718b20ad80c9677bf4f2118002
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell-1|TCGA-Thryoid / Sample_Type by Project: Shred V9

ADAMTS2 POSTN CD1E IL22RA2 RTL3

1.26e-04156138545a05c7a45a3ec8551818ab67f18b3b9553934c1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 IRF6 EXOC6B FBXO32 PATJ

1.26e-0415613857569cab30caafcb273e8ef0b73c9e1bf87076984
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABCA12 ADGRG6 DST TOP1MT CADPS2

1.29e-04157138519c0599a669803c4db1f174de1ce755e562a50a3
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3|TCGA-Skin / Sample_Type by Project: Shred V9

SESN3 XPO4 REV3L ASAP1 NAA16

1.37e-041591385fb222c42f66901852b01cec073ec0732245ee973
ToppCellSevere-B_naive-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

INTS6L SETX ARHGEF18 PATJ SORL1

1.37e-0415913852881b054bbeb479221ee3c38bbd9b0815b123579
ToppCellsevere_influenza-B_cell|World / disease group, cell group and cell class (v2)

PLXNA3 ZCCHC18 CEP120 SIK2

1.48e-048613847b595bcba4bcb72b7de7c06e19f690f0c739c529
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MYO5A SYNE1 ADGRG6 ITPR2 CCR1

1.54e-0416313854b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SAMHD1 CD1E IL22RA2 GUCA1B SACS

1.73e-0416713851bd0aa7a3c8649f342bb856cf861c4c5984ad889
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACA MALT1 CEP120 GUCA1B DNM3

1.73e-041671385528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACA MALT1 CEP120 GUCA1B DNM3

1.73e-041671385a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS2 LAMA2 SAMHD1 REV3L POSTN

1.83e-041691385c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAMTS2 LAMA2 POSTN TRPM1 PLXNA1

1.83e-041691385335619507857383c3b0b507cdf05d786ed59e585
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCED1A KCNK12 KIFAP3 CEP120 SACS

1.88e-04170138532917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FRMPD1 CCDC51 CCR1 TFB2M UEVLD

1.93e-0417113857c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCellControl-B_naive-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

INTS6L SETX RETREG2 ARHGEF18 VIRMA

1.93e-041711385d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACA HJURP DZIP1 TMEM26 AMIGO2

2.04e-0417313858bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACA HJURP DZIP1 TMEM26 AMIGO2

2.04e-0417313853e3c61468e703330788a10d850ef41a85680f86d
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ACACA KALRN CEP120 SIK2 PATJ

2.09e-041741385a1f745962a104c6f4b86b7e482da8755384c773a
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZCCHC18 ZCCHC12 ARHGEF18 RAB33A PLXNA1

2.09e-041741385742c73c9e090848b464323cb17579b86658c6792
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZCCHC18 ZCCHC12 ARHGEF18 RAB33A PLXNA1

2.09e-0417413857fed9722e64c60843092f2ba71256e3043011ef6
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACACA ADAMTS2 SYNE1 DZIP1 TMEM26

2.15e-0417513851d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ACACA KALRN CEP120 SIK2 PATJ

2.15e-04175138578a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACACA ADAMTS2 SYNE1 DZIP1 TMEM26

2.15e-041751385427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

VPS11 MALT1 TOP1MT PATJ PLXNA1

2.20e-041761385437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXNA3 POSTN RTL3 PLXNA1 AMIGO2

2.26e-04177138530f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

ITPR3 C20orf96 IL22RA2 TFB2M NAA16

2.38e-04179138568511e87b12b8253de7771e5ccfc5869248b8450
ToppCellE18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXL13 KALRN SYNE1 LRRC70 ASAP1

2.45e-041801385ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCellE18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXL13 KALRN SYNE1 LRRC70 ASAP1

2.45e-0418013854e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCellE18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXL13 KALRN SYNE1 LRRC70 ASAP1

2.45e-041801385466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 SYNE1 LAMA2 PCARE POSTN

2.51e-041811385a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAUS6 SETX KALRN ADGRL4 CADPS2

2.51e-041811385fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO4 LAMA2 ADGRG6 POSTN UNC80

2.51e-041811385d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 SYNE1 LAMA2 PCARE POSTN

2.51e-041811385526e858a848470b6d2d5248788004d9735ed3add
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SESN3 VIRMA ZZZ3 PARP9 PATJ

2.57e-0418213851aea96ee211f7b9caef7fd385233f51be6021a73
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SESN3 VIRMA ZZZ3 PARP9 PATJ

2.57e-041821385b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANO4 MYO5B FRMPD1 POSTN NOS1

2.57e-041821385a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SESN3 VIRMA ZZZ3 PARP9 PATJ

2.57e-041821385c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SESN3 VIRMA ZZZ3 PARP9 PATJ

2.57e-0418213854cb182ef39be2044a6ad7266f332d4177591e550
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANO4 MYO5B FRMPD1 POSTN NOS1

2.64e-0418313855a541a7f6c3514be8a13e988185dfe388c874f8b
ToppCellCOVID-19_Mild-NK_activated|COVID-19_Mild / Disease condition and Cell class

RETREG2 SYNE1 ECPAS VIRMA PARP9

2.64e-04183138522bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

KALRN ADGRL4 DNM3 CADPS2 TBCD

2.64e-041831385ff95382cfed592190d0636d2b750328471f82e0d
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO4 LAMA2 ADGRG6 POSTN FBXO32

2.64e-04183138512daaea821e49bc94a01e2496331e92a80d27339
DiseaseMicrovillus inclusion disease

MYO5B STX3

1.96e-0521312C0341306
Diseaseurinary pH measurement

KALRN WDR72

1.94e-0451312EFO_0010136
DiseaseCerebellar Ataxia

SYNE1 SNX14

1.94e-0451312C0007758
DiseaseUterine leiomyoma

NUP107 SYNE1 TEX11 DNM3

7.36e-04911314HP_0000131
DiseaseOptic Atrophy

SLC25A46 TBCD

8.60e-04101312C0029124
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR2 ITPR3

1.25e-03121312DOID:1441 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth Disease

SLC25A46 SETX

1.25e-03121312C0007959
Diseasebody weight

ZCCHC12 RPS6KA5 TEX11 VIRMA ADGRG6 RAB33A IPO9 CEP120 RTL3 DNM3 SENP6 PATJ CADPS2 PLXNA1

1.47e-03126113114EFO_0004338
DiseaseCholestasis

MYO5B SRP72 CADPS2 SORL1

1.49e-031101314C0008370
DiseaseMalformations of Cortical Development

DYNC1H1 TBCD

1.72e-03141312C1955869
DiseaseCortical Dysplasia

DYNC1H1 TBCD

1.72e-03141312C0431380
Diseasesulfate measurement

CADPS2 HTT

1.72e-03141312EFO_0007864
DiseaseDrug habituation

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C0013170
DiseaseDrug abuse

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C0013146
DiseasePrescription Drug Abuse

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C4316881
DiseaseSubstance-Related Disorders

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C0236969
DiseaseDrug Use Disorders

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C0013222
DiseaseDrug Dependence

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C1510472
DiseaseSubstance Dependence

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C0038580
DiseaseSubstance Use Disorders

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

ANO4 SYNE1 PATJ CADPS2

1.75e-031151314C0029231
DiseaseSubstance abuse problem

ANO4 SYNE1 PATJ CADPS2

1.81e-031161314C0740858
Diseaseneuroblastoma

KALRN MALT1 EXOC6B FBXO32

1.81e-031161314EFO_0000621
Diseasemuscular dystrophy (is_implicated_in)

SYNE1 LAMA2

2.55e-03171312DOID:9884 (is_implicated_in)
Diseaserenovascular hypertension (biomarker_via_orthology)

LAMA2 NOS1

3.18e-03191312DOID:1591 (biomarker_via_orthology)
Diseaseskin pigmentation

ADAMTS2 HERC2 CADPS2

3.62e-03691313EFO_0003784
Diseaseactivities of daily living score measurement

PATJ NOS1

3.89e-03211312EFO_0008451
DiseaseIntellectual Disability

SYNE1 SNX14 SACS TFB2M DYNC1H1 TBCD HTT

3.90e-034471317C3714756
DiseaseColorectal Carcinoma

ACACA KALRN ABCA12 SYNE1 POSTN ZZZ3 SACS PROS1 SORL1

4.19e-037021319C0009402

Protein segments in the cluster

PeptideGeneStartEntry
IKDYNILTRITQLGI

ADGRL4

421

Q9HBW9
QRIYSLEQLLQEAVL

BAHCC1

1951

Q9P281
YQSLLTKNKARVIIL

ADRB2

141

P07550
LIAQSLLEKQQIYLE

ARHGEF18

826

Q6ZSZ5
LRKANSVLLVVQKVY

ABCA12

286

Q86UK0
YIRVAVSLRNQKVIL

ADGRG6

146

Q86SQ4
IYKQGINIRLDTTLI

ANKRD13C

251

Q8N6S4
NYANVELILDIAKRI

ACACA

186

Q13085
VFQELKVLEVLLLYN

AMIGO2

136

Q86SJ2
RAQILIYAILQALDL

AADACL3

216

Q5VUY0
NVLYEKVALLLTNLE

ANO4

566

Q32M45
INVVLVRIILLSYGK

ADAMTS2

311

O95450
IVKLQVINLAAKLYL

AP3B2

536

Q13367
LRRKYLTQVDILLQG

HJURP

146

Q8NCD3
LDGIIILYTILELQK

MROH7

631

Q68CQ1
SSLDQYVQIRIFKII

RAB33A

26

Q14088
LLAKIDNELVVRAYT

CYB5R2

56

Q6BCY4
VLIQYLEKVLEKINS

INTS6L

831

Q5JSJ4
YIQLLIREKHTNLIA

NUP107

576

P57740
GKLQRAIVSILNYVI

PARP9

211

Q8IXQ6
SNNYRIVKEILIRLS

ITPR2

1176

Q14571
ILEILQFILNVRLDY

ITPR3

971

Q14573
NELEKIIAELLYSLQ

LTN1

1021

O94822
TIIDILEYSNKKRLQ

C20orf96

156

Q9NUD7
ILVVSYVIILRSLKN

OR4C12

211

Q96R67
LQVLIVDYLKGLSVN

MDN1

916

Q9NU22
LYTQQKVEILTALRK

LZIC

126

Q8WZA0
VYELTNLLRQLDFKV

MALT1

366

Q9UDY8
IVLAILELLKYHQRV

HDAC1

156

Q13547
RLQQLATLIQKIYRG

MYO1A

696

Q9UBC5
YIAIVIATNEKLRSL

NLRP11

851

P59045
KQRLVILERYFIALN

HERC2

141

O95714
LQQELITNELAYKIL

DST

1876

Q03001
LQAESRQLVDLYKVL

IL12RB2

756

Q99665
LLNETKYRKVLQLQI

FSIP2

2076

Q5CZC0
TKDQVLLLIDIQVSY

DNM3

471

Q9UQ16
IRLYLQELITITQKA

ECPAS

1521

Q5VYK3
DKLIRQQIDYKTLTL

PLXNA1

1491

Q9UIW2
DKLIRQQIDYKTLTL

PLXNA3

1466

P51805
IYSLFNVISILIKQV

KCNK12

291

Q9HB15
SIQRAVYKDLVLLLQ

PCED1A

41

Q9H1Q7
KALQISTLEERLQIY

NAA16

266

Q6N069
QRITKYQLLLKELLT

KALRN

1416

O60229
LAYLRAIDVKILQQL

LURAP1

66

Q96LR2
LLYRVFIINNSLEKE

IL22RA2

201

Q969J5
TVLANLKRVLLQITY

LAMA2

676

P24043
IKNYDSTTRIIIQIL

KCNU1

436

A8MYU2
LGIIYRDIKLENILL

RPS6KA5

171

O75582
LKNLIVLFADTLQVY

EXOC6B

401

Q9Y2D4
LLSYIQIIQAILRIH

OR10G3

216

Q8NGC4
NLIYLKLDRNRIISI

LRRC70

301

Q7Z2Q7
VFLTAIALNRYLKVV

OXER1

181

Q8TDS5
ILQEQLAESVYRALK

NOS1

1331

P29475
LVILSYTNIIRTILK

OR6C74

211

A6NCV1
VVTNNQLLRVKYLLV

PARP16

256

Q8N5Y8
VALVYIKRLLTSANI

CCNYL3

96

P0C7X3
IIVTEKTNILLRYLH

DDA1

46

Q9BW61
EIYNRKSVLLTLIAV

ATM

1146

Q13315
VLNRYLDIKEILQSL

CD1E

171

P15812
QYQLLRCNVDLLKII

CNOT7

61

Q9UIV1
LARALAQYLVVVSKL

HTT

2221

P42858
RELLAALQKVVVPIY

CHERP

231

Q8IWX8
GNILVVLVLVQYKRL

CCR1

51

P32246
VEILRVYLALQSKLQ

CEP120

256

Q8N960
VYLQDVKVLTLLLES

FRMPD1

461

Q5SYB0
IKSRDLLALIQVYAE

ASAP1

571

Q9ULH1
RLDLQLHIYQLKTLI

CADPS2

1221

Q86UW7
LRIQQIIYCHKLTII

FBXL13

76

Q8NEE6
LAIIAQVLSYKEAVL

CAMP

26

P49913
LAIRQLASVILKQYV

IPO9

71

Q96P70
NYLRTLINELVKGIL

DYNC1H1

4446

Q14204
VYEAGKLNLLTVIQL

HAUS6

296

Q7Z4H7
QYQLLRCNVDLLKII

CNOT8

61

Q9UFF9
VDLRTQLVLYENALK

FHOD1

321

Q9Y613
YVVRLLELIAKSQLT

FBXO32

121

Q969P5
LVTYRNLINKLSVVD

UTP3

301

Q9NQZ2
RRKVLILNYLQTAVS

SLC22A6

161

Q4U2R8
VIVKAYLQVLSVLRD

SACS

1916

Q9NZJ4
TDVFLQIYKVLVLSR

CFAP47

1701

Q6ZTR5
LLIAKNTRLEIYVVT

DDB1

31

Q16531
LVVKQEQLLRVALYL

KIFAP3

271

Q92845
LVILSYTNIIRTILK

OR6C75

211

A6NL08
LLQQLLQYTVSKLQV

PCARE

266

A6NGG8
NIVAQLKQLYRILQT

IRF6

431

O14896
AASYIVLKLENEIRQ

RTL3

6

Q8N8U3
YLTKDFEQLISIILR

RRN3

101

Q9NYV6
ILKQYQTLREALVAA

UTY

1246

O14607
KNLLVNTLYTVRVAA

SORL1

1711

Q92673
AKNFLVVVLQLYRLV

TMEM26

291

Q6ZUK4
YQALLLQVLEQIKFL

SYNE1

3686

Q8NF91
VQEAILARKEYASLI

SYNE1

4666

Q8NF91
ERKKLLSYIQRLVQI

SAMHD1

96

Q9Y3Z3
YVNRVRLQELKALLL

CCDC51

221

Q96ER9
IQQINIELYRLFGIK

GIN1

211

Q9NXP7
RLELLNIVEGIYQLK

GUCA1B

111

Q9UMX6
LTFQIHLQELLQYKR

RETREG2

166

Q8NC44
VQLAYVQLIRSLLKE

SETX

531

Q7Z333
ILELNKVQLLYEQIG

SIK2

611

Q9H0K1
RELLDQLQQKLYLIQ

TFB2M

286

Q9H5Q4
LVVRDVNTLQILQLY

WRAP73

31

Q9P2S5
RTEEALQLYNQIIKL

SRP72

241

O76094
LLSVENTVIYRIQAL

PROS1

551

P07225
VLLKLIRLAQFTIEY

DZIP1

116

Q86YF9
YQSQARKKLIIIIVL

STX3

256

Q13277
RLYDIILQNLVELLQ

SRP68

426

Q9UHB9
LQLIKVTRLQYLNAL

CNNM3

636

Q8NE01
NIRAIYLTLEKLIQS

TTPAL

161

Q9BTX7
LQILLEKVAATLEYL

PRAMEF6

341

Q5VXH4
ATLSVIRDYLVQKLQ

VPS11

766

Q9H270
NLQKYVREQILLAVA

XPO4

106

Q9C0E2
LDLSVVLKAVYLVLN

UNC80

651

Q8N2C7
LAKYLQLRNVIERLQ

UXT

46

Q9UBK9
LLFETRDISLIKQYV

REV3L

2876

O60673
VLNKQLTYVLLDIVI

SNX14

911

Q9Y5W7
AVLQITKIIYSTLLQ

SLC25A46

401

Q96AG3
LLKNAYGRIILQVVA

PATJ

1746

Q8NI35
NQLLERSLKVYIKTV

SESN3

426

P58005
LQILLEKVAATLEYL

PRAMEF5

341

Q5TYX0
IVYLLSRLFLVNKLV

WDR72

901

Q3MJ13
KILSYNRANRVVAIL

TOP1MT

451

Q969P6
QAAVASLEQLYVKLI

TEX11

146

Q8IYF3
VNKLTNLEEQYIILI

SENP6

536

Q9GZR1
DIVISKLTQILSYLR

IK

276

Q13123
YLTKDFEQLISIILR

RRN3P2

101

A6NIE6
LLLYREQLVKILQRT

PSME4

691

Q14997
DSLVKILQDYNLQIL

VPS41

741

P49754
LREQLLVTIQKTFNY

TRPM1

306

Q7Z4N2
VLDQAVQIINYIKAR

ZBED5

391

Q49AG3
LDSQRLQYIITNVLK

UEVLD

321

Q8IX04
SLYVIRLEVQLQNAI

ZCCHC18

146

P0CG32
NSYSIKVVLQELRRL

UBE2V2

111

Q15819
RLVDVVAVILKALTY

TBCD

436

Q9BTW9
ILIRDKNALQNIILY

POSTN

551

Q15063
FRRVQSLILDLKYVL

UBR2

471

Q8IWV8
YQKLLELILLDQTVR

VIRMA

531

Q69YN4
KDYQRLLQTIAVLEA

ZZZ3

501

Q8IYH5
SLYVIRLEVQLQNAI

ZCCHC12

146

Q6PEW1
VLEIQLQALDIRLSY

VPS13D

2566

Q5THJ4
VLSDLAIQIYQQLVR

MYO5A

1601

Q9Y4I1
DLSIQIYQQLIKIAE

MYO5B

1596

Q9ULV0