Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	UDP-glucose:glycoprotein glucosyltransferase activity	UGGT1 UGGT2	9.18e-06	2	61	2	GO:0003980
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	2.54e-04	8	61	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D	4.07e-04	10	61	2	GO:0140999
GeneOntologyMolecularFunction	unfolded protein binding	CCT5 CHAF1A UGGT1 UGGT2	5.97e-04	126	61	4	GO:0051082
GeneOntologyMolecularFunction	UDP-glucosyltransferase activity	UGGT1 UGGT2	7.01e-04	13	61	2	GO:0035251
GeneOntologyBiologicalProcess	UDP-glucosylation	UGGT1 UGGT2	8.60e-06	2	61	2	GO:0097359
GeneOntologyBiologicalProcess	clathrin coat assembly	AP1B1 AP2B1 SNAP91	4.18e-05	23	61	3	GO:0048268
GeneOntologyBiologicalProcess	cAMP metabolic process	PDE4C PDE4D ADCY3	5.40e-05	25	61	3	GO:0046058
GeneOntologyBiologicalProcess	UDP-alpha-D-glucose metabolic process	UGGT1 UGGT2	1.28e-04	6	61	2	GO:0006011
GeneOntologyCellularComponent	clathrin adaptor complex	AP1B1 AP2B1 SNAP91	1.10e-04	31	63	3	GO:0030131
GeneOntologyCellularComponent	extrinsic component of presynaptic endocytic zone membrane	AP2B1 SNAP91	1.86e-04	7	63	2	GO:0098894
GeneOntologyCellularComponent	clathrin vesicle coat	AP1B1 AP2B1 SNAP91	2.04e-04	38	63	3	GO:0030125
GeneOntologyCellularComponent	AP-type membrane coat adaptor complex	AP1B1 AP2B1 SNAP91	4.10e-04	48	63	3	GO:0030119
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C KMT2D	5.79e-04	12	63	2	GO:0044666
GeneOntologyCellularComponent	clathrin coat	AP1B1 AP2B1 SNAP91	6.45e-04	56	63	3	GO:0030118
GeneOntologyCellularComponent	AP-2 adaptor complex	AP2B1 SNAP91	7.95e-04	14	63	2	GO:0030122
GeneOntologyCellularComponent	presynaptic endocytic zone membrane	AP2B1 SNAP91	7.95e-04	14	63	2	GO:0098835
GeneOntologyCellularComponent	clathrin coat of endocytic vesicle	AP2B1 SNAP91	9.15e-04	15	63	2	GO:0030128
GeneOntologyCellularComponent	vesicle coat	AP1B1 AP2B1 SNAP91	1.09e-03	67	63	3	GO:0030120
GeneOntologyCellularComponent	presynaptic endocytic zone	AP2B1 SNAP91	1.33e-03	18	63	2	GO:0098833
GeneOntologyCellularComponent	extrinsic component of presynaptic membrane	AP2B1 SNAP91	1.33e-03	18	63	2	GO:0098888
GeneOntologyCellularComponent	clathrin coat of coated pit	AP2B1 SNAP91	1.81e-03	21	63	2	GO:0030132
Domain	UDP-g_GGtrans	UGGT1 UGGT2	9.81e-06	2	59	2	IPR009448
Domain	-	AP1B1 AP2B1	9.81e-06	2	59	2	2.60.40.1150
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	9.81e-06	2	59	2	IPR013037
Domain	UDP-g_GGTase	UGGT1 UGGT2	9.81e-06	2	59	2	PF06427
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	2.94e-05	3	59	2	IPR016342
Domain	B2-adapt-app_C	AP1B1 AP2B1	2.94e-05	3	59	2	PF09066
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	5.86e-05	4	59	2	IPR015151
Domain	B2-adapt-app_C	AP1B1 AP2B1	5.86e-05	4	59	2	SM01020
Domain	LRR_1	LRWD1 LRSAM1 FSHR LRRC40 LRRIQ4 FBXL5	6.51e-05	219	59	6	PF00560
Domain	FYrich_C	KMT2C KMT2D	9.75e-05	5	59	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	9.75e-05	5	59	2	IPR003888
Domain	AP_beta	AP1B1 AP2B1	9.75e-05	5	59	2	IPR026739
Domain	FYRC	KMT2C KMT2D	9.75e-05	5	59	2	SM00542
Domain	FYRN	KMT2C KMT2D	9.75e-05	5	59	2	SM00541
Domain	FYRN	KMT2C KMT2D	9.75e-05	5	59	2	PF05964
Domain	FYRC	KMT2C KMT2D	9.75e-05	5	59	2	PF05965
Domain	FYRC	KMT2C KMT2D	9.75e-05	5	59	2	PS51543
Domain	FYRN	KMT2C KMT2D	9.75e-05	5	59	2	PS51542
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	1.46e-04	6	59	2	IPR012295
Domain	-	AP1B1 AP2B1	1.46e-04	6	59	2	3.30.310.10
Domain	Leu-rich_rpt	LRWD1 LRSAM1 FSHR LRRC40 LRRIQ4 FBXL5	2.09e-04	271	59	6	IPR001611
Domain	Coatomer/calthrin_app_sub_C	AP1B1 AP2B1	2.71e-04	8	59	2	IPR009028
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	3.48e-04	9	59	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	3.48e-04	9	59	2	PF02883
Domain	Alpha_adaptinC2	AP1B1 AP2B1	3.48e-04	9	59	2	SM00809
Domain	Leu-rich_rpt_4	LRWD1 LRRIQ4	4.34e-04	10	59	2	IPR025875
Domain	LRR_4	LRWD1 LRRIQ4	4.34e-04	10	59	2	PF12799
Domain	-	LRWD1 LRSAM1 FSHR LRRC40 LRRIQ4 FBXL5	5.15e-04	321	59	6	3.80.10.10
Domain	L_dom-like	LRWD1 LRSAM1 FSHR LRRC40 LRRIQ4 FBXL5	5.77e-04	328	59	6	IPR032675
Domain	Coatomer/clathrin_app_Ig-like	AP1B1 AP2B1	6.34e-04	12	59	2	IPR013041
Domain	Clathrin/coatomer_adapt-like_N	AP1B1 AP2B1	1.00e-03	15	59	2	IPR002553
Domain	Adaptin_N	AP1B1 AP2B1	1.00e-03	15	59	2	PF01602
Domain	Post-SET_dom	KMT2C KMT2D	1.14e-03	16	59	2	IPR003616
Domain	PostSET	KMT2C KMT2D	1.14e-03	16	59	2	SM00508
Domain	POST_SET	KMT2C KMT2D	1.14e-03	16	59	2	PS50868
Domain	PDEase	PDE4C PDE4D	1.62e-03	19	59	2	IPR023088
Domain	PDEase_I	PDE4C PDE4D	1.98e-03	21	59	2	PF00233
Domain	PDEASE_I	PDE4C PDE4D	1.98e-03	21	59	2	PS00126
Domain	PDEase_CS	PDE4C PDE4D	1.98e-03	21	59	2	IPR023174
Domain	EPHD	KMT2C KMT2D	2.18e-03	22	59	2	PS51805
Domain	-	PDE4C PDE4D	2.18e-03	22	59	2	1.10.1300.10
Domain	Leu-rich_rpt_typical-subtyp	LRWD1 LRSAM1 LRRC40 LRRIQ4	2.36e-03	177	59	4	IPR003591
Domain	LRR_TYP	LRWD1 LRSAM1 LRRC40 LRRIQ4	2.36e-03	177	59	4	SM00369
Domain	PDEase_catalytic_dom	PDE4C PDE4D	2.38e-03	23	59	2	IPR002073
Domain	HDc	PDE4C PDE4D	2.59e-03	24	59	2	SM00471
Domain	HD/PDEase_dom	PDE4C PDE4D	2.59e-03	24	59	2	IPR003607
Domain	LRR	LRWD1 LRSAM1 LRRC40 LRRIQ4	3.73e-03	201	59	4	PS51450
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D ZNF281	1.68e-06	13	64	3	17761849
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4C PDE4D LPL	1.68e-06	13	64	3	8009369
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	KMT2C AP1B1 CCT5 MYO9A ADCY3 VARS1 GGT7	2.16e-06	322	64	7	26514267
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	3.33e-06	2	64	2	28483418
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	3.33e-06	2	64	2	34156443
Pubmed	Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.	UGGT1 UGGT2	3.33e-06	2	64	2	10694380
Pubmed	Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells.	KMT2D ZNF281	3.33e-06	2	64	2	29036642
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	3.33e-06	2	64	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	3.33e-06	2	64	2	27280393
Pubmed	ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes.	LPL C3	3.33e-06	2	64	2	14703506
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	3.33e-06	2	64	2	36869380
Pubmed	NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A.	CDC25A NPAS2	3.33e-06	2	64	2	28333141
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	3.33e-06	2	64	2	28967912
Pubmed	Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT).	UGGT1 UGGT2	3.33e-06	2	64	2	24140206
Pubmed	Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2.	UGGT1 UGGT2	3.33e-06	2	64	2	33320095
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	3.33e-06	2	64	2	25346535
Pubmed	Effects of domain composition on catalytic activity of human UDP-glucose:glycoprotein glucosyltransferases.	UGGT1 UGGT2	3.33e-06	2	64	2	27496766
Pubmed	The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain.	UGGT1 UGGT2	3.33e-06	2	64	2	12913004
Pubmed	Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase are enzymatically active.	UGGT1 UGGT2	3.33e-06	2	64	2	24415556
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	3.33e-06	2	64	2	36601880
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D KDM8	7.72e-06	21	64	3	27626377
Pubmed	Integrative Molecular Analyses of an Individual Transcription Factor-Based Genomic Model for Lung Cancer Prognosis.	SATB2 NPAS2	9.99e-06	3	64	2	34925645
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	9.99e-06	3	64	2	23932714
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	9.99e-06	3	64	2	22183980
Pubmed	Chromosomal locations and gonadal dependence of genes that mediate resistance to ectromelia (mousepox) virus-induced mortality.	LPL C3	9.99e-06	3	64	2	2002550
Pubmed	Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells.	UGGT1 UGGT2	9.99e-06	3	64	2	11278576
Pubmed	Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies.	C3 LRP8	9.99e-06	3	64	2	29716893
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	9.99e-06	3	64	2	21683083
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	2.00e-05	4	64	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	2.00e-05	4	64	2	34645806
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	2.00e-05	4	64	2	28398509
Pubmed	Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.	AP1B1 AP2B1	2.00e-05	4	64	2	17290217
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4C PDE4D	2.00e-05	4	64	2	9371714
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4C PDE4D	2.00e-05	4	64	2	24732776
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4C PDE4D	2.00e-05	4	64	2	34943270
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	2.00e-05	4	64	2	23129768
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4C PDE4D	2.00e-05	4	64	2	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4C PDE4D	2.00e-05	4	64	2	8413254
Pubmed	A conserved clathrin assembly motif essential for synaptic vesicle endocytosis.	AP2B1 SNAP91	2.00e-05	4	64	2	11102472
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	2.00e-05	4	64	2	24081332
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4C PDE4D	2.00e-05	4	64	2	22946044
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4C PDE4D	2.00e-05	4	64	2	33609559
Pubmed	ATM binds to beta-adaptin in cytoplasmic vesicles.	AP1B1 AP2B1	2.00e-05	4	64	2	9707615
Pubmed	Adipose tissue gene expression of factors related to lipid processing in obesity.	LPL C3	2.00e-05	4	64	2	21966368
Pubmed	Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.	AP1B1 AP2B1	2.00e-05	4	64	2	7534311
Pubmed	Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.	FSHR GLIS3 HPSE2	2.33e-05	30	64	3	24554482
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2C KMT2D LRWD1 CHAF1A BCL7C ZNF281 NUP160	2.48e-05	469	64	7	27634302
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C KMT2D CCT5	2.57e-05	31	64	3	20516061
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TACO1 SATB2 KMT2D LRWD1 ZFHX4 CHAF1A CDC25A VARS1 NUP160	2.63e-05	857	64	9	25609649
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	KMT2C SATB2 KMT2D LRWD1 AP1B1 AP2B1 CCT5 ZNF281 INO80D VARS1	3.16e-05	1103	64	10	34189442
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4C PDE4D	3.32e-05	5	64	2	33944911
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	3.32e-05	5	64	2	31127101
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4C PDE4D	3.32e-05	5	64	2	8586960
Pubmed	A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.	SNAP91 UBAP1	3.32e-05	5	64	2	22479182
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	3.32e-05	5	64	2	32601106
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	3.32e-05	5	64	2	26744420
Pubmed	Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.	AP1B1 AP2B1	3.32e-05	5	64	2	16723738
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	4.64e-05	351	64	6	38297188
Pubmed	Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin.	AP2B1 SNAP91	4.98e-05	6	64	2	12732633
Pubmed	Clathrin.	AP1B1 AP2B1	4.98e-05	6	64	2	10966473
Pubmed	Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites.	AP2B1 SNAP91	4.98e-05	6	64	2	10748223
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	4.98e-05	6	64	2	17021013
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4C PDE4D	4.98e-05	6	64	2	18923023
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PDE4D AP1B1 AP2B1 CCT5 UGGT1 LRSAM1 UBAP1 ELP2 VARS1 NUP160 EIF3CL	6.39e-05	1455	64	11	22863883
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	6.96e-05	7	64	2	30604749
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	6.96e-05	7	64	2	36598580
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	6.96e-05	7	64	2	19556342
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	AP1B1 AP2B1 CCT5 UGGT1 C3 CDC25A VARS1 NUP160 GGT7	7.07e-05	974	64	9	28675297
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	AP1B1 AP2B1 UGGT1 LRRC40 ELP2 VARS1 NUP160	7.59e-05	560	64	7	35241646
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	9.27e-05	8	64	2	21447625
Pubmed	Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation.	SATB2 LRP8	9.27e-05	8	64	2	26341353
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	9.27e-05	8	64	2	30335158
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D	9.27e-05	8	64	2	23130995
Pubmed	A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.	AP1B1 AP2B1	9.27e-05	8	64	2	9811611
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D	9.27e-05	8	64	2	22266653
Pubmed	Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.	TMEM132D GRIN3A ADGRV1	1.16e-04	51	64	3	11853319
Pubmed	EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.	AP1B1 SNAP91	1.19e-04	9	64	2	12538641
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D	1.19e-04	9	64	2	22665483
Pubmed	Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.	CHAF1A PAN2	1.19e-04	9	64	2	17785442
Pubmed	Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.	AP1B1 AP2B1	1.19e-04	9	64	2	12429846
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	PDE4D RHPN2 TMEM132D HPSE2 KDM8 GRIN3A ADGRV1 GASK1A	1.21e-04	814	64	8	23251661
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	AP1B1 SNAP91 LONP2 MYO9A OSBPL6 ADGRV1	1.41e-04	430	64	6	32581705
Pubmed	Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome.	AP1B1 AP2B1	1.49e-04	10	64	2	12383505
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	C3 ADCY3	1.49e-04	10	64	2	11884542
Pubmed	MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.	AP2B1 ELP2 USPL1 ZNF281	1.73e-04	150	64	4	22678362
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	1.81e-04	11	64	2	37012455
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	AP1B1 RHPN2 LONP2 LPL UGGT2 ELP2 ERGIC2	1.90e-04	650	64	7	38777146
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D	2.17e-04	12	64	2	27563068
Pubmed	Molecular logic of cellular diversification in the mouse cerebral cortex.	SATB2 LPL	2.17e-04	12	64	2	34163074
Pubmed	The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.	CCT5 PPRC1 CDC25A	2.39e-04	65	64	3	29150431
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	2.57e-04	13	64	2	21502505
Pubmed	Getting in and out from calnexin/calreticulin cycles.	UGGT1 UGGT2	2.57e-04	13	64	2	18303019
Pubmed	Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.	AP1B1 AP2B1	2.57e-04	13	64	2	9882340
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PDE4D AP1B1 AP2B1 SNAP91 CCT5 MYO9A OSBPL6 PACS2 VARS1 EIF3CL	2.69e-04	1431	64	10	37142655
Pubmed	Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.	SATB2 LRP8	2.99e-04	14	64	2	21460838
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	2.99e-04	14	64	2	12482968
Pubmed	Primary cilia are required in a unique subpopulation of neural progenitors.	SATB2 ADCY3	2.99e-04	14	64	2	25114218
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	KMT2C KMT2D CCT5 CHAF1A ZNF281 INO80D	3.01e-04	495	64	6	27705803
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	LRWD1 AP1B1 AP2B1 LRRC40 VARS1	3.26e-04	323	64	5	24797263
Pubmed	LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.	AP1B1 SNAP91	3.45e-04	15	64	2	21307259
Interaction	FOXI1 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C VARS1	4.23e-07	92	63	6	int:FOXI1
Interaction	TBXT interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	1.66e-06	116	63	6	int:TBXT
Interaction	PAX7 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	2.45e-06	124	63	6	int:PAX7
Interaction	LHX1 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C	1.76e-05	103	63	5	int:LHX1
Interaction	TLX1 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	1.77e-05	175	63	6	int:TLX1
Interaction	PAX6 interactions	KMT2C SATB2 KMT2D PDE4C ZFHX4 CHAF1A BCL7C ZNF281	1.78e-05	366	63	8	int:PAX6
Interaction	TEAD1 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	1.83e-05	176	63	6	int:TEAD1
Interaction	PAX8 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C	2.52e-05	111	63	5	int:PAX8
Interaction	TBR1 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C	2.75e-05	113	63	5	int:TBR1
Interaction	HNF1B interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	2.82e-05	190	63	6	int:HNF1B
Interaction	TOB2 interactions	TMEM132D CHAF1A PAN2	3.20e-05	20	63	3	int:TOB2
Interaction	FOXL1 interactions	KMT2C SATB2 KMT2D ZFHX4 ZNF281 VARS1	3.36e-05	196	63	6	int:FOXL1
Interaction	GATA2 interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	3.66e-05	199	63	6	int:GATA2
Interaction	FOXB1 interactions	SATB2 LRWD1 ZFHX4 VARS1 NUP160	6.44e-05	135	63	5	int:FOXB1
Interaction	ERG interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	6.89e-05	223	63	6	int:ERG
Interaction	NFIX interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C ZNF281	7.60e-05	227	63	6	int:NFIX
Interaction	FOXQ1 interactions	SATB2 LRWD1 ZFHX4 VARS1 NUP160	7.92e-05	141	63	5	int:FOXQ1
Interaction	NFIB interactions	KMT2C SATB2 KMT2D BCL7C ZNF281	8.19e-05	142	63	5	int:NFIB
Interaction	ELF5 interactions	KMT2C SATB2 KMT2D BCL7C ZNF281	9.65e-05	147	63	5	int:ELF5
Interaction	SOX7 interactions	KMT2C SATB2 KMT2D ZFHX4	1.26e-04	82	63	4	int:SOX7
Interaction	CRX interactions	KMT2C SATB2 KMT2D ZFHX4 BCL7C NPAS2	1.41e-04	254	63	6	int:CRX
Interaction	TRIB3 interactions	CCT5 CHAF1A GLIS3 SAXO1 CDC25A	1.44e-04	160	63	5	int:TRIB3
Interaction	PAX2 interactions	KMT2C SATB2 KMT2D ZFHX4	1.45e-04	85	63	4	int:PAX2
Interaction	GSC interactions	KMT2C SATB2 KMT2D ZFHX4	1.59e-04	87	63	4	int:GSC
Interaction	SOX17 interactions	KMT2C SATB2 KMT2D ZNF281	2.23e-04	95	63	4	int:SOX17
Interaction	SOX9 interactions	KMT2C KMT2D BCL7C ZNF281	2.42e-04	97	63	4	int:SOX9
Interaction	GATA3 interactions	SATB2 KMT2D ZFHX4 BCL7C ZNF281	2.96e-04	187	63	5	int:GATA3
GeneFamily	UDP-glucose glycoprotein glucosyltransferases	UGGT1 UGGT2	5.79e-06	2	44	2	440
GeneFamily	Neuroblastoma breakpoint family	NBPF19 NBPF15	1.42e-03	23	44	2	662
GeneFamily	Phosphodiesterases	PDE4C PDE4D	1.54e-03	24	44	2	681
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D	3.09e-03	34	44	2	487
GeneFamily	Ubiquitin specific peptidases	PAN2 USPL1	8.20e-03	56	44	2	366
Coexpression	GSE22229_RENAL_TRANSPLANT_IMMUNOSUPP_THERAPY_VS_HEALTHY_PBMC_DN	SATB2 PDE4D UGGT1 LPL C3 LRP8	8.42e-06	199	63	6	M7479
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 MYO9A TMEM132D GLIS3 C3	3.59e-06	164	63	5	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 GLIS3 KIAA1755 HPSE2 ADGRV1	6.80e-06	187	63	5	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 OSBPL6 GLIS3 HPSE2 ADGRV1	9.41e-06	200	63	5	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 OSBPL6 GLIS3 HPSE2 ADGRV1	9.41e-06	200	63	5	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 OSBPL6 GLIS3 HPSE2 ADGRV1	9.41e-06	200	63	5	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 OSBPL6 GLIS3 HPSE2 ADGRV1	9.41e-06	200	63	5	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 OSBPL6 GLIS3 HPSE2 ADGRV1	9.41e-06	200	63	5	01819446deeab9054f5cfe889d53bb49d137dbc0
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLVS2 LPL GJC1 ADCY3	7.24e-05	157	63	4	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 FSHR ADGRV1 SAXO1	7.79e-05	160	63	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 FSHR ADGRV1 SAXO1	7.79e-05	160	63	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LPL ELP2 EIF3CL FAN1	8.98e-05	166	63	4	f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LPL C3 LRP8 FAN1	9.63e-05	169	63	4	305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCell	RSV-Healthy-2\|Healthy / Virus stimulation, Condition and Cluster	CCT5 CHAF1A BCL7C CDC25A	1.10e-04	175	63	4	c47440c0b0513e67fe13b85f10dd8a8d42d0e9a3
ToppCell	RSV-Healthy-2\|RSV / Virus stimulation, Condition and Cluster	CCT5 CHAF1A BCL7C CDC25A	1.10e-04	175	63	4	0e97189585b7afaf3bd622c3ef10c86412393829
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	KMT2D AP2B1 OSBPL6 FRMPD3	1.13e-04	176	63	4	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHAF1A CDC25A ADCY3 LRP8	1.15e-04	177	63	4	cbedac0bddb8fc330a464815c905928c553b0fc0
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CHAF1A CDC25A ADCY3 LRP8	1.18e-04	178	63	4	04bfecf5ea5d85c843e48d08718b5d69e7bf834e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NBPF19 SATB2 LPL FSHR	1.20e-04	179	63	4	8766a5a066091879f521acfc612abf563ff78808
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NBPF19 TMEM132D FSHR GLIS3	1.25e-04	181	63	4	57994ff4ecffb15653aee00644d9f887f5e3461d
ToppCell	LA-07._Pericyte\|World / Chamber and Cluster_Paper	PDE4C CLVS2 GJC1 ADCY3	1.31e-04	183	63	4	e3835db4795362b0442d5893baf2a78efcc20428
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLVS2 LPL GJC1 ADCY3	1.31e-04	183	63	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLVS2 LPL GJC1 ADCY3	1.34e-04	184	63	4	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB2 KIAA1755 FRMPD3 ADGRV1	1.34e-04	184	63	4	e123ad8ee46a032825a0bd4b3586ddcb3eda03d4
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLVS2 LPL GJC1 ADCY3	1.34e-04	184	63	4	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	GLIS3 KIAA1755 C3 GASK1A	1.36e-04	185	63	4	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LPL GJC1 HPSE2 ADCY3	1.39e-04	186	63	4	6568358812f0ca4e0161a1a1b29682fbced35c79
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 KIAA1755 HPSE2 ADGRV1	1.42e-04	187	63	4	5c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 GLIS3 HPSE2 ADGRV1	1.42e-04	187	63	4	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 KIAA1755 HPSE2 ADGRV1	1.42e-04	187	63	4	93c78fc7f126132eb84feb47be2c4e8c568b9e91
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LPL OSBPL6 GJC1 ADCY3	1.42e-04	187	63	4	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 GLIS3 HPSE2 ADGRV1	1.42e-04	187	63	4	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 KIAA1755 HPSE2 ADGRV1	1.42e-04	187	63	4	5d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 MYO9A GLIS3 ADGRV1	1.45e-04	188	63	4	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 MYO9A TMEM132D GLIS3	1.45e-04	188	63	4	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LPL OSBPL6 GJC1 ADCY3	1.45e-04	188	63	4	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	PDE4C GLIS3 C3 ADCY3	1.48e-04	189	63	4	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	PDE4C GLIS3 UGGT2 ADCY3	1.48e-04	189	63	4	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	C3 FRMPD3 ADCY3 GASK1A	1.51e-04	190	63	4	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 KIAA1755 HPSE2 ADGRV1	1.51e-04	190	63	4	b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KMT2D PAN2 UGGT2 FBXL5	1.51e-04	190	63	4	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 PDE4D RHPN2 GLIS3	1.54e-04	191	63	4	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 MYO9A TMEM132D GLIS3	1.54e-04	191	63	4	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	CV-Healthy-2\|Healthy / Virus stimulation, Condition and Cluster	CCT5 CHAF1A GJC1 CDC25A	1.57e-04	192	63	4	a249787f7e2f50af49bd7d4752c411a067a5e3d3
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 GLIS3 HPSE2 ADGRV1	1.57e-04	192	63	4	43beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KMT2D PAN2 UGGT2 FBXL5	1.57e-04	192	63	4	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 GLIS3 HPSE2 ADGRV1	1.60e-04	193	63	4	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 RHPN2 TMEM132D C3	1.60e-04	193	63	4	ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZFHX4 GLIS3 HPSE2 ADGRV1	1.60e-04	193	63	4	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LPL GJC1 HPSE2 ADCY3	1.64e-04	194	63	4	b4f4730a53a63118c02a3692a9c52adfd7201598
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	NBPF19 ZFHX4 GLIS3 ADGRV1	1.74e-04	197	63	4	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	NBPF19 ZFHX4 GLIS3 ADGRV1	1.74e-04	197	63	4	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LPL GJC1 HPSE2 ADCY3	1.74e-04	197	63	4	fd65a9b41df618ff2a09d76dcf9f1ca3f3bdf52a
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYO9A C3 FRMPD3 ADGRV1	1.74e-04	197	63	4	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	PDE4D MYO9A GLIS3 ADGRV1	1.77e-04	198	63	4	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TACO1 SATB2 GJC1 ADCY3	1.77e-04	198	63	4	882710bd6215e299257dd3df234292db9a2823ba
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4D MYO9A C3 ADGRV1	1.80e-04	199	63	4	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NBPF19 GLIS3 HPSE2 ADGRV1	1.84e-04	200	63	4	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	Kidney-Fibroblasts\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	ZFHX4 SNAP91 C3 LRP8	1.84e-04	200	63	4	2c265ad8314a21bce50ac21b16da2fea125366ea
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMEM132D FSHR C3	2.91e-04	91	63	3	b0658e020f80e56fab9d2aa07e321d9b33d7af2c
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	4.07e-06	2	60	2	DOID:0080598 (implicated_via_orthology)
Disease	autosomal recessive polycystic kidney disease (is_marker_for)	C3 CDC25A	2.43e-05	4	60	2	DOID:0110861 (is_marker_for)
Disease	middle cerebral artery infarction (biomarker_via_orthology)	AP2B1 SNAP91 C3	9.11e-04	93	60	3	DOID:3525 (biomarker_via_orthology)
Disease	age at menarche	SATB2 PDE4D ZFHX4 SNAP91 ADCY3 GGT7	1.29e-03	594	60	6	EFO_0004703
Disease	Sezary Syndrome	KMT2C KMT2D	1.38e-03	27	60	2	C0036920
Disease	neuroimaging measurement	SNAP91 RHPN2 CHAF1A FSHR GLIS3 GJC1 KIAA1755 LRP8	1.39e-03	1069	60	8	EFO_0004346
Disease	cortical thickness	SATB2 SNAP91 CHAF1A FSHR GLIS3 KIAA1755 ADGRV1 LRP8	1.80e-03	1113	60	8	EFO_0004840
Disease	cesarean section, Self-injurious behavior	LPL GASK1A	1.94e-03	32	60	2	EFO_0009636, HP_0100716
Disease	lifestyle measurement, maximum cigarettes per day measurement	PDE4D C3 SAXO1	1.99e-03	122	60	3	EFO_0009264, EFO_0010724

Protein segments in the cluster

Peptide	Gene	Start	Entry
EISESHPNSNLLDLN	AP2B1	186	P63010
EDGHTDNHLPLLENN	ERGIC2	361	Q96RQ1
LADQLHQPVNDDILN	ADGRV1	5631	Q8WXG9
APDHQELNLDVSLQL	C3	1286	P01024
EIAESHPSSNLLDLN	AP1B1	186	Q10567
DALLEFDVHPNELTN	SNAP91	176	O60641
PDLEASLDTLENNCH	CHAF1A	66	Q13111
ELDLSNNHLETLPDN	LRWD1	51	Q9UFC0
DQNLLNFLPEQEHSE	NPAS2	126	Q99743
DAHLNPSLLQNVELD	PAN2	26	Q504Q3
ELDTLDNLETNDPNL	KMT2C	2731	Q8NEZ4
DNLETNDPNLDDLLR	KMT2C	2736	Q8NEZ4
AAALLEVLDPEQNHN	LONP2	456	Q86WA8
LDLHDNQLTALPDDL	LRSAM1	86	Q6UWE0
LEDNLLTHLPENLDS	LRRIQ4	451	A6NIV6
PDDTLLNEILDNTLN	IMPG1	201	Q17R60
LEALDLSSPQELHQA	KIAA1755	206	Q5JYT7
LLHNTSQVDVENPDL	KDM8	356	Q8N371
LHPDLQSNLLQVDSE	GGT7	596	Q9UJ14
SIHLFIDSLLNEENP	LPL	271	P06858
VHPDAQDLLDTLEDN	PDE4C	616	Q08493
HPDAQDILDTLEDNR	PDE4D	691	Q08499
QLNHILISDDQLPEN	PACS2	476	Q86VP3
ENFLSLQLDPSIIHD	HPSE2	76	Q8WWQ2
ELNEPLNTLQHLCEE	OSBPL6	591	Q9BZF3
ESQNPLHLQLSLENS	GRIN3A	231	Q8TCU5
QHLSDPDEDQNSLAL	GASK1A	376	Q9UFP1
LEESENLHNADQPLR	EIF3CL	426	B5ME19
PLILLDLNDENSNQS	BCL7C	86	Q8WUZ0
SHEENLPADLEALQR	GJC1	326	P36383
DSLHLSQQEDSLPVQ	FRMPD3	1076	Q5JV73
HAQQLALPQATLDDD	GLIS3	321	Q8NEA6
EDEHELNQLLNEALL	ADCY3	581	O60266
PHDLELNQEDFSDVL	INO80D	611	Q53TQ3
PNLEHLDLTQTDISD	FBXL5	356	Q9UKA1
SLNHVLCNQDSDLPE	ELP2	481	Q6IA86
DELNLSDNNNLEELP	FSHR	196	P23945
THLASLEDELQEQPD	PPRC1	321	Q5VV67
EQLSNLEDLDLSNNH	LRRC40	171	Q9H9A6
LEDLDLSNNHLTTVP	LRRC40	176	Q9H9A6
EISILAENLNNPHDI	LRP8	661	Q14114
SLDHDIFQLIDPDEN	CDC25A	126	P30304
LQDDSCLNNDIPHSI	FAN1	341	Q9Y2M0
HNQLLNSNLDPSEVE	VARS1	886	P26640
HLSVDDSENPNQREL	SAXO1	456	Q8IYX7
LLDDNSHLQTIPSDL	TMEM132D	871	Q14C87
QHLVQKLSPENDNDD	NBPF15	156	Q8N660
QHLVQKLSPENDNDD	NBPF19	156	A0A087WUL8
PDLEQAAHLIQALSN	TACO1	271	Q9BSH4
DQEAIHTLSAQLDLP	SATB2	641	Q9UPW6
FDDEANHLLLQNNLP	CCT5	306	P48643
DVPLDTLESNLQHLS	NUP160	786	Q12769
QHQEEDDLLNLIDAP	RHPN2	456	Q8IUC4
ARLELNENPDTLHQD	CLVS2	16	Q5SYC1
QDHSLDDLCSQLAQP	ATG4D	436	Q86TL0
LHQQGLAPEEDNLSE	ZFHX4	1056	Q86UP3
LNALANDTLDLPHFD	USPL1	1071	Q5W0Q7
LLLHNNDQDNALEDL	UBAP1	481	Q9NZ09
HQQLTPSQELDDLID	ZNF281	756	Q9Y2X9
QHQEDDDLLNLIHAP	RHPN2P1	371	A8MT19
DLESPLINNIDQTLH	TEX50	121	A0A1B0GTY4
HPTLQADDDSLLDQD	SLC30A4	66	O14863
LSQDPNSLSNLDQDL	UGGT2	1416	Q9NYU1
LSQDPNSLSNLDQDL	UGGT1	1441	Q9NYU2
GTLENLETNDPHLDD	KMT2D	3026	O14686
LETNDPHLDDLLNGD	KMT2D	3031	O14686
LLHLLDEESNFPQAT	MYO9A	606	B2RTY4