Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncyclosporin A binding

PPIAL4C PPIAL4E PPIAL4D PPIAL4H PPIAL4A PPIAL4G PPIA PPIAL4F

4.39e-1424838GO:0016018
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

PPIAL4C PPIAL4E PPIAL4D PPIAL4H PPIAL4A PPIAL4G PPIA PPIAL4F

2.94e-1150838GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

PPIAL4C PPIAL4E PPIAL4D PPIAL4H PPIAL4A PPIAL4G PPIA PPIAL4F

4.80e-1153838GO:0016859
GeneOntologyMolecularFunctionisomerase activity

PPIAL4C PPIAL4E PPIAL4D PPIAL4H SREBF2 PPIAL4A PPIAL4G PPIA PPIAL4F

1.04e-07192839GO:0016853
GeneOntologyMolecularFunctionamide binding

CACNA1B PPIAL4C PPIAL4E PPIAL4D PPIAL4H PPIAL4A PNPLA3 PPIAL4G PPIA PPIAL4F

4.52e-072998310GO:0033218
GeneOntologyMolecularFunctionpoly(A) RNA polymerase activity

PAPOLB TENT5B PAPOLG

1.48e-0512833GO:1990817
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

TYK2 TLK2 JAK3 PARP11 POLR3B NEK10 GRK4 SYK PAPOLB TRRAP MAP4K4 TENT5B PTK6 PAPOLG

2.97e-059388314GO:0016772
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

TYK2 JAK3 SYK PTK6

3.96e-0546834GO:0004715
GeneOntologyMolecularFunctionmono-olein transacylation activity

PNPLA4 PNPLA3

5.11e-053832GO:0051264
GeneOntologyMolecularFunctiondiolein transacylation activity

PNPLA4 PNPLA3

5.11e-053832GO:0051265
GeneOntologyMolecularFunctionadenylyltransferase activity

PAPOLB TENT5B PAPOLG

2.86e-0431833GO:0070566
GeneOntologyMolecularFunctionnucleotidyltransferase activity

PARP11 POLR3B PAPOLB TENT5B PAPOLG

4.31e-04152835GO:0016779
GeneOntologyMolecularFunctiongrowth hormone receptor binding

TYK2 JAK3

7.52e-0410832GO:0005131
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1B CACNA1I

1.50e-0314832GO:0008331
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

PPIAL4C PPIAL4E PPIAL4D PPIAL4H PPIAL4A PPIAL4G PPIA PPIAL4F

1.76e-1238818GO:0000413
GeneOntologyBiologicalProcesspeptidyl-proline modification

PPIAL4C PPIAL4E PPIAL4D PPIAL4H PPIAL4A PPIAL4G PPIA PPIAL4F

3.57e-1154818GO:0018208
GeneOntologyBiologicalProcessprotein folding

PPIAL4C PPIAL4E PPIAL4D SACS PPIAL4H PPIAL4A PPIAL4G PPIA PPIAL4F

5.21e-07246819GO:0006457
GeneOntologyBiologicalProcessregulation of thymocyte apoptotic process

JAK3 RORC TP53

6.34e-0520813GO:0070243
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

TLK2 JAK3 PPIAL4C PPIAL4E PPIAL4D PPIAL4H SYK PPIAL4A PPIAL4G PPIA TP53 PTK6 PPIAL4F

1.04e-049768113GO:0018193
GeneOntologyBiologicalProcessprotein maturation

PPIAL4C PPIAL4E PPIAL4D SACS PPIAL4H TLL2 PPIAL4A PPIAL4G PPIA PPIAL4F

1.52e-046198110GO:0051604
GeneOntologyBiologicalProcessthymocyte apoptotic process

JAK3 RORC TP53

1.59e-0427813GO:0070242
DomainCyclophilin-type_PPIase_CS

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

1.32e-1019806IPR020892
DomainCyclophilin-type_PPIase

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

2.63e-1021806IPR024936
DomainCyclophilin-like_dom

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

3.60e-1022806IPR029000
DomainCSA_PPIASE_2

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

3.60e-1022806PS50072
DomainPro_isomerase

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

3.60e-1022806PF00160
Domain-

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

3.60e-10228062.40.100.10
DomainCyclophilin-type_PPIase_dom

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

3.60e-1022806IPR002130
DomainCSA_PPIASE_1

PPIAL4C PPIAL4D PPIAL4A PPIAL4G PPIA PPIAL4F

3.60e-1022806PS00170
Domain-

PAPOLB PAPOLG

5.42e-0538023.30.70.590
DomainPAP_central

PAPOLB PAPOLG

5.42e-053802PF04928
DomainPAP_RNA-bind

PAPOLB PAPOLG

5.42e-053802PF04926
DomainPolA_pol_cen_dom

PAPOLB PAPOLG

5.42e-053802IPR007012
DomainPolA_pol_RNA-bd_dom

PAPOLB PAPOLG

5.42e-053802IPR007010
DomainROR_rcpt

RORB RORC

5.42e-053802IPR003079
DomainPolyA_polymerase

PAPOLB PAPOLG

5.42e-053802IPR014492
DomainNuclTrfase_I_C

PAPOLB PAPOLG

5.42e-053802IPR011068
DomainPROTEIN_KINASE_TYR

TYK2 JAK3 NEK10 SYK PTK6

6.02e-0597805PS00109
DomainTyr_kinase_AS

TYK2 JAK3 NEK10 SYK PTK6

6.02e-0597805IPR008266
DomainTyr_kinase_non-rcpt_Jak/Tyk2

TYK2 JAK3

1.08e-044802IPR016251
DomainPLPL

PNPLA4 PNPLA3

1.80e-045802IPR033562
DomainProtein_kinase_ATP_BS

TYK2 TLK2 JAK3 NEK10 GRK4 SYK MAP4K4 PTK6

2.17e-04379808IPR017441
DomainEGF_CA

FAT4 TLL2 CUBN SVEP1

5.08e-0486804PF07645
DomainKinase-like_dom

TYK2 TLK2 JAK3 NEK10 GRK4 SYK TRRAP MAP4K4 PTK6

5.08e-04542809IPR011009
DomainTyrKc

TYK2 JAK3 SYK PTK6

5.54e-0488804SM00219
DomainTyr_kinase_cat_dom

TYK2 JAK3 SYK PTK6

5.54e-0488804IPR020635
DomainPatatin/PLipase_A2-rel

PNPLA4 PNPLA3

6.40e-049802IPR002641
DomainPatatin

PNPLA4 PNPLA3

6.40e-049802PF01734
DomainPNPLA

PNPLA4 PNPLA3

6.40e-049802PS51635
DomainPROTEIN_KINASE_ATP

TYK2 TLK2 JAK3 NEK10 GRK4 SYK MAP4K4 PTK6

7.72e-04459808PS00107
DomainVDCCAlpha1

CACNA1B CACNA1I

7.97e-0410802IPR002077
DomainEGF_Ca-bd_CS

FAT4 TLL2 CUBN SVEP1

7.99e-0497804IPR018097
DomainEGF_CA

FAT4 TLL2 CUBN SVEP1

8.63e-0499804PS01187
DomainNTP_transf_2

PAPOLB PAPOLG

9.72e-0411802PF01909
DomainPolymerase_NTP_transf_dom

PAPOLB PAPOLG

9.72e-0411802IPR002934
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT4 TLL2 CUBN SVEP1

1.11e-03106804IPR000152
DomainProt_kinase_dom

TYK2 TLK2 JAK3 NEK10 GRK4 SYK MAP4K4 PTK6

1.16e-03489808IPR000719
DomainCUB

TLL2 CUBN SEZ6

1.21e-0349803PF00431
DomainDNAJ_1

DNAJC13 DNAJC14 SACS

1.21e-0349803PS00636
DomainDNAJ_2

DNAJC13 DNAJC14 SACS

1.21e-0349803PS50076
DomainDnaJ

DNAJC13 DNAJC14 SACS

1.21e-0349803SM00271
Domain-

DNAJC13 DNAJC14 SACS

1.21e-03498031.10.287.110
DomainPROTEIN_KINASE_DOM

TYK2 TLK2 JAK3 NEK10 GRK4 SYK MAP4K4 PTK6

1.22e-03493808PS50011
DomainSH2

TYK2 JAK3 SYK PTK6

1.28e-03110804SM00252
DomainCUB

TLL2 CUBN SEZ6

1.28e-0350803SM00042
DomainSH2

TYK2 JAK3 SYK PTK6

1.32e-03111804PS50001
DomainDnaJ_domain

DNAJC13 DNAJC14 SACS

1.36e-0351803IPR001623
DomainSH2

TYK2 JAK3 SYK PTK6

1.37e-03112804IPR000980
Domain-

TYK2 JAK3 SYK PTK6

1.37e-031128043.30.505.10
Domain-

TLL2 CUBN SEZ6

1.44e-03528032.60.120.290
DomainCUB

TLL2 CUBN SEZ6

1.52e-0353803PS01180
DomainEGF_CA

FAT4 TLL2 CUBN SVEP1

1.87e-03122804SM00179
DomainCUB_dom

TLL2 CUBN SEZ6

1.87e-0357803IPR000859
DomainChannel_four-helix_dom

CACNA1B CACNA1I SLC9C2

1.87e-0357803IPR027359
Domain-

CACNA1B CACNA1I SLC9C2

1.87e-03578031.20.120.350
DomainEGF-like_Ca-bd_dom

FAT4 TLL2 CUBN SVEP1

1.98e-03124804IPR001881
DomainPkinase_Tyr

TYK2 JAK3 SYK PTK6

2.29e-03129804PF07714
DomainAcyl_Trfase/lysoPLipase

PNPLA4 PNPLA3

2.36e-0317802IPR016035
DomainSer-Thr/Tyr_kinase_cat_dom

TYK2 JAK3 SYK PTK6

2.92e-03138804IPR001245
Pubmed

Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation.

TP53 FANCA

5.76e-06284229307578
Pubmed

Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia.

TP53 FANCA

5.76e-06284236191479
Pubmed

NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.

NEK10 TP53

5.76e-06284232561851
Pubmed

Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells.

TARDBP TP53

5.76e-06284222133803
Pubmed

Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides.

JAK3 TP53

5.76e-06284226082451
Pubmed

TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2.

TARDBP SREBF2

5.76e-06284235568729
Pubmed

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

TYK2 JAK3

5.76e-06284220478313
Pubmed

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

SREBF2 TP53

5.76e-06284222265415
Pubmed

JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma.

TYK2 JAK3

5.76e-06284233083484
Pubmed

ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor.

MIB1 TP53

5.76e-06284223442362
Pubmed

Mitochondria-targeted catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28/miR-200b/PP2A-Cα axis.

CAT TP53

5.76e-06284238844154
Pubmed

A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias.

TYK2 JAK3 SYK

7.44e-061684319464057
Pubmed

Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53-Mdm2 Axis.

NPAS4 TP53

1.73e-05384234257081
Pubmed

TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.

TARDBP TP53

1.73e-05384229802307
Pubmed

Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.

TRRAP TP53

1.73e-05384212138177
Pubmed

Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.

PNPLA4 PNPLA3

1.73e-05384216150821
Pubmed

THE PROGNOSTIC SIGNIFICANCE OF P53, BCL2 AND MIB1 EXPRESSIONS RELATED WITH OTHER CLINICOPATHOLOGICAL VARIABLES IN SEROUS OVARIAN CARCINOMAS. A CLINICOPATHOLOGICAL STUDY IN PERITONEAL FLUIDS.

MIB1 TP53

1.73e-05384226204652
Pubmed

Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations.

SREBF2 TP53

1.73e-05384226512780
Pubmed

INMAP overexpression inhibits cell proliferation, induces genomic instability and functions through p53/p21 pathways.

POLR3B TP53

1.73e-05384225635878
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

RALY PARP11 POLR3B RTCA TRMT11 ANKRD17 CAT KLHL8 TRRAP MAP4K4 TP53

3.01e-051005841119615732
Pubmed

Three distinct signalling responses by murine fibroblasts to genotoxic stress.

JAK3 TP53

3.45e-0548428918879
Pubmed

p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells.

TP53 FANCA

3.45e-05484230977208
Pubmed

Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade.

ISLR TP53

3.45e-05484235236758
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1B DMXL2

3.45e-05484231253182
Pubmed

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.

SYK RORC

3.45e-05484230709742
Pubmed

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.

PNPLA4 PNPLA3

3.45e-05484215364929
Pubmed

Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA.

PPIA TP53

3.45e-05484228394340
Pubmed

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.

TYK2 JAK3

3.45e-05484224843152
Pubmed

SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.

TP53 FANCA

3.45e-05484226676373
Pubmed

Tat-dependent occlusion of the HIV poly(A) site.

PAPOLB PAPOLG

3.45e-0548428491200
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

RALY TYK2 DNAJC13 FAM120A USP40 DAB1 SREBF2 ANKRD17 LRBA ZNF512 SNX9 TRRAP PTK6

5.68e-051489841328611215
Pubmed

Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression.

TRRAP TP53

5.74e-05584212897156
Pubmed

The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas.

TYK2 TP53

5.74e-05584221878673
Pubmed

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.

RORC TP53

5.74e-05584230955884
Pubmed

The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.

TYK2 JAK3

5.74e-05584210531356
Pubmed

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

TARDBP SREBF2

5.74e-05584234347016
Pubmed

The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells.

SREBF2 TRRAP

5.74e-05584222288532
Pubmed

Genetic variance in the adiponutrin gene family and childhood obesity.

PNPLA4 PNPLA3

5.74e-05584219390624
Pubmed

CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.

TYK2 JAK3 DAB1 TP53

6.05e-058784429991678
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

JAK3 DAB1 SYK PTK6

6.91e-059084416273093
Pubmed

The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis.

RALY TP53

8.59e-05684236952348
Pubmed

Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system.

RORB RORC

8.59e-05684214966198
Pubmed

The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.

RALY TARDBP

8.59e-05684230354839
Pubmed

The molecular regulation of Janus kinase (JAK) activation.

TYK2 JAK3

8.59e-05684225057888
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RALY TARDBP DNAJC13 POLR3B FAM120A RTCA MIB1 ANKRD17 CAT ZNF512 PPIA TRRAP

9.72e-051353841229467282
Pubmed

The molecular basis of JAK/STAT inhibition by SOCS1.

TYK2 JAK3

1.20e-04784229674694
Pubmed

Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.

JAK3 TP53

1.20e-04784228191885
Pubmed

JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice.

JAK3 TP53

1.20e-04784229242197
Pubmed

FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS.

TARDBP FIG4

1.20e-04784220472325
Pubmed

STAM2, a new member of the STAM family, binding to the Janus kinases.

TYK2 JAK3

1.60e-04884210899310
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1B CACNA1I

1.60e-04884228330839
Pubmed

Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.

ISLR TP53

1.60e-04884231439548
Pubmed

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

TP53 FANCA

1.60e-04884229323295
Pubmed

Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.

PPIA TP53

2.05e-04984220644252
Pubmed

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.

PNPLA4 PNPLA3

2.05e-04984219029121
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1B CACNA1I

2.05e-04984216382099
Pubmed

Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.

SYK TP53

2.05e-04984215536084
Pubmed

Tel2 regulates the stability of PI3K-related protein kinases.

TRRAP TP53

2.56e-041084218160036
Pubmed

Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.

JAK3 SYK

2.56e-041084210825200
Pubmed

Real-time resolution of point mutations that cause phenovariance in mice.

JAK3 MAP4K4

2.56e-041084225605905
Pubmed

[Establishment of a multiplex ligation-dependent SNP genotyping method and its application in the detection of genes related to chemotherapeutic drugs in breast cancer].

CAT TP53

2.56e-041084219538885
Pubmed

Characterization of the human patatin-like phospholipase family.

PNPLA4 PNPLA3

2.56e-041084216799181
Pubmed

Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.

FAT4 TRRAP

3.13e-041184224349473
Pubmed

Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage.

TRRAP TP53

3.13e-041184218250150
Pubmed

Human lung myofibroblasts as effectors of the inflammatory process: the common receptor gamma chain is induced by Th2 cytokines, and CD40 ligand is induced by lipopolysaccharide, thrombin and TNF-alpha.

TYK2 JAK3

3.75e-041284212207328
Pubmed

Amyotrophic lateral sclerosis: an update on recent genetic insights.

TARDBP FIG4

3.75e-041284224085347
Pubmed

Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.

RORB RORC

3.75e-041284235613048
Pubmed

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.

JAK3 SYK

3.75e-041284210872802
Pubmed

The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis.

RORB TP53

3.75e-041284237139782
Pubmed

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.

SREBF2 CAT

4.42e-041384232266253
Pubmed

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

TYK2 JAK3

4.42e-041384223990909
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

TARDBP PPIAL4D GPATCH1 PPIAL4A ZNF512 PPIAL4G PPIA TP53 PPIAL4F

4.96e-0495484936373674
Pubmed

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

FAT4 MIB1 TP53

5.82e-046784321875946
Pubmed

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

MED25 TRRAP

5.93e-041584218418385
Pubmed

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.

TARDBP FAM120A PPIA TP53

6.11e-0415984431332168
Pubmed

Guanine Nucleotide-Binding Protein-Like 1 (GNL1) binds RNA G-quadruplex structures in genes associated with Parkinson's disease.

RALY FAM120A

7.66e-041784233305682
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

RALY TARDBP SACS CAT SNX9 PPIA TRRAP MAP4K4 TP53

8.20e-04102484924711643
Pubmed

Novel cell lines promote the discovery of genes involved in early heart development.

TYK2 JAK3

8.60e-041884211437454
Pubmed

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.

DCAF10 TP53

8.60e-041884231257023
Pubmed

Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.

RORB TP53

8.60e-041884237054704
Pubmed

A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.

JAK3 ANKRD17

9.60e-041984234360789
Pubmed

Daxx Inhibits HIV-1 Reverse Transcription and Uncoating in a SUMO-Dependent Manner.

PPIA TP53

9.60e-041984232545337
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED25 SREBF2

9.60e-041984216799563
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

TYK2 DMXL2 FAM120A SREBF2 ANKRD17 MAP4K4 FANCA

1.01e-0365084738777146
Pubmed

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.

MIB1 DAB1 RORB

1.05e-038284331073041
Pubmed

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

CUBN FANCA

1.06e-032084223824729
Pubmed

Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.

DAB1 RORB

1.06e-032084212130536
Pubmed

Transcriptional regulation of cortical neuron migration by POU domain factors.

DAB1 RORB

1.06e-032084211859196
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF225 ZNF229

1.06e-032084212743021
Pubmed

The protein tyrosine kinase family of the human genome.

JAK3 SYK PTK6

1.09e-038384311114734
Pubmed

DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

DCAF15 DCAF10

1.17e-032184230111536
Pubmed

The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.

TYK2 FIG4 PPIA

1.20e-038684326885983
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

RALY CACNA1B DNAJC13 USP40 TP53 FANCA

1.30e-0349684631343991
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

RALY TARDBP MICAL1 FAM120A RTCA SYK PPIA

1.55e-0370184730196744
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

RALY TARDBP POLR3B RTCA ANKRD17 LRBA TRRAP

1.59e-0370484729955894
Pubmed

Candidate gene analysis in primary lymphedema.

SYK RORC

1.67e-032584218564921
Pubmed

Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.

TYK2 SYK

1.67e-032584215254900
Pubmed

The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.

MIB1 DAB1

1.80e-032684223988635
Pubmed

ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.

TARDBP LRBA

1.80e-032684225228645
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

DNAJC13 DCAF10 GSDMB ISLR PPIA

1.85e-0336184526167880
InteractionPPIAL4G interactions

FAT4 PPIAL4C PPIAL4E PPIAL4G PPIA

1.07e-0730795int:PPIAL4G
Cytoband1q21.2

PPIAL4C PPIAL4E PPIAL4D PDZK1P1 PPIAL4F

2.15e-07718451q21.2
CytobandEnsembl 112 genes in cytogenetic band chr1q21

PPIAL4C PPIAL4E PPIAL4D PPIAL4H PDZK1P1 RORC PPIAL4G PPIAL4F

8.17e-07404848chr1q21
Cytoband9q22

SYK RORB

5.54e-04198429q22
GeneFamilyPatatin like phospholipase domain containing

PNPLA4 PNPLA3

4.17e-0410562466
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

DNAJC13 DNAJC14 SACS

4.69e-0449563584
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF15 DCAF10

1.40e-0318562498
GeneFamilyCalcium voltage-gated channel subunits

CACNA1B CACNA1I

2.92e-0326562253
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ERICH3 NEK10 SLC9C2 FBXO15 TSPAN1 CFAP65

2.03e-0620083696701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

1.96e-05176835dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

2.49e-051858350998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

2.49e-051858353e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

ERICH3 NEK10 SLC9C2 TSPAN1 CFAP65

2.49e-0518583518a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

HSD17B6 MIB1 GSDMB LRBA TSPAN1

2.62e-05187835b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

HSD17B6 MIB1 GSDMB LRBA TSPAN1

2.62e-0518783561c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERICH3 NEK10 SLC9C2 FBXO15 CFAP65

2.76e-05189835a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

ERICH3 NEK10 SLC9C2 FBXO15 CFAP65

2.76e-0518983527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERICH3 NEK10 SLC9C2 TSPAN1 CFAP65

2.90e-05191835e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERICH3 NEK10 SLC9C2 TSPAN1 CFAP65

2.90e-051918359d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERICH3 NEK10 SLC9C2 TSPAN1 CFAP65

2.90e-051918351c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.13e-05194835756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.21e-05195835cfcf554b436083179dea1d6fd6e3a800ea2430fe
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERICH3 BCO2 NEK10 TSPAN1 CFAP65

3.21e-0519583579dc031258579ea328181dda33710dd897f1064a
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.21e-0519583507a6bcef6af93ed87df455dee624037cb75e011a
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.21e-05195835e7f069f557a59ee7b502ff82ad4c9f47fa619ba8
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAK3 TTC39C DAB1 CACNA1I RORC

3.45e-05198835e2aa1a2e5b188997e09686608cf0df55e61bd8b6
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.45e-051988356d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCelldistal-Epithelial-Ciliated-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.53e-051998352de1fe124737a6cca4b3805ab3056f9d9d7c16c7
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERICH3 NEK10 SLC9C2 FBXO15 CFAP65

3.53e-051998352498237b9e895ca4826a3378d9d40989968df72b
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERICH3 NEK10 SLC9C2 FBXO15 CFAP65

3.53e-05199835542ec45c931b40738df1f3777b00c83be33a514a
ToppCellBiopsy_Control_(H.)-Epithelial-Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.62e-052008359ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERICH3 NEK10 SLC9C2 TSPAN1 CFAP65

3.62e-05200835926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.62e-052008355abd6d81e1cc354484ae693fcd708d78926e75b5
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ERICH3 NEK10 FBXO15 TSPAN1 CFAP65

3.62e-052008359c9d2b0276c7b0709c2eeeb0673a2f58106fb14e
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERICH3 NEK10 SLC9C2 TSPAN1 CFAP65

3.62e-0520083506ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma-2|TCGA-Pancreas / Sample_Type by Project: Shred V9

CACNA1B FBXO15 SEZ6 CFAP65

1.60e-04146834bc2adef529d0bbfcccef7435401a47a6ffcc1832
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma|TCGA-Pancreas / Sample_Type by Project: Shred V9

CACNA1B FBXO15 SEZ6 CFAP65

1.60e-0414683472c1e7e0c2b6ff6c4084af61fa19c2b8eab16eda
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DCAF15 SACS FIG4 RORB

1.78e-04150834c2c51a3230c978e2fdb1b3ae14193d4014431b25
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB1 UGT8 RORB TENT5B

1.97e-041548341e32969bee810adaf2d560f0824a16227df513d8
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NEK10 FBXO15 TSPAN1 CFAP65

1.97e-041548344e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NEK10 FBXO15 TSPAN1 CFAP65

1.97e-041548347556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9C2 FBXO15 TSPAN1 CFAP65

2.02e-041558345f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellCOVID-CD4-antiviral_CD4|COVID / Condition, Cell_class and T cell subcluster

JAK3 GPATCH1 CACNA1I ZNF225

2.02e-041558347e5ae034036fe85915d38a24195501e6d3bcbfb0
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9C2 FBXO15 TSPAN1 CFAP65

2.02e-041558340944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

JAK3 NEK10 LRBA CFAP65

2.07e-0415683410d191e29b16cae8238e8df6c0ff38882253f34e
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LHFPL4 SYK PAPOLB KBTBD12

2.12e-04157834ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellLPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UGT8 RORC TP53 PTK6

2.12e-04157834bd45590da540a557dc8096980a45220fccb99505
ToppCellLPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UGT8 RORC TP53 PTK6

2.12e-0415783400c9a58b033b8b95b0d838f233dd077b62d8b02a
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-LMPP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAT4 BCO2 TMTC4 ZNF225

2.27e-0416083460fa1c717410aad7e8647703cb416cd7617cac29
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LHFPL4 SYK PAPOLB KBTBD12

2.44e-041638348dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LHFPL4 SYK PAPOLB KBTBD12

2.44e-04163834fd243ca223079033be480a24817a399f281fa4d4
ToppCellCiliated_cells-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

ERICH3 BCO2 NEK10 SLC9C2

2.62e-041668344b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCell15-Distal-Epithelial-Multiciliated_cell|Distal / Age, Tissue, Lineage and Cell class

ERICH3 FBXO15 TSPAN1 CFAP65

2.80e-04169834425d89ab69e9f9eb3df84056676423e390cc6ab1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related|GW23 / Sample Type, Dataset, Time_group, and Cell type.

FAM120A UGT8 SLC9C2 SEZ6

2.80e-0416983429db25e7c5f31d98a08a35d7ec5ade203242bc50
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related-Oligodendrocyte/OPC|GW23 / Sample Type, Dataset, Time_group, and Cell type.

FAM120A UGT8 SLC9C2 SEZ6

2.80e-04169834b1611e61f635f8f9b87250e026ad30999cbee041
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

JAK3 MICAL1 SYK PNPLA3

2.87e-04170834e0429f45a3639a10294ceb492f2286c495481c2b
ToppCellCiliated_cells-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

ERICH3 NEK10 TSPAN1 CFAP65

3.00e-04172834187ae91148d293537afc77e10da2b64302322224
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERICH3 TSPAN1 SEZ6 CFAP65

3.00e-041728342651dece87c3e3d2d6370f5274ebae357474b825
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ERICH3 FBXO15 TSPAN1 CFAP65

3.13e-04174834b8d1c556290d188f56aeefc17f03119686945fe7
ToppCellInt-URO-Lymphocyte-T_NK-MAIT|Int-URO / Disease, Lineage and Cell Type

DAB1 RORB RORC LRBA

3.13e-041748345227ed29f5f0d3e0aaa7f3cfd362f96d3e2660f7
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ERICH3 FBXO15 TSPAN1 CFAP65

3.13e-0417483400cf27bc23af1472a507be31fba6245a8fdd901b
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ERICH3 FBXO15 TSPAN1 CFAP65

3.20e-04175834b1369d2b74f461e6822d0c33e9b50fe0dfbceb54
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 TMTC4 SVEP1 SEZ6

3.20e-041758349d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ERICH3 FBXO15 TSPAN1 CFAP65

3.20e-04175834c82ec6deb6ccdd991a69a62b6d62d5b14c803d7a
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1B TLL2 MED25 SVEP1

3.34e-04177834164ffbbf798defa3728197deb1a14b661490e525
ToppCellLPS-antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JAK3 CACNA1B SYK CAT

3.41e-04178834289d1425c4e57fabcca994b27f9af1c0ce5d5bec
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

3.41e-04178834de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell5'-Adult-LargeIntestine-Hematopoietic-T_cells-MAIT_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TTC39C RORC SNX9 SEZ6

3.41e-04178834f52f837e948deb6a2d031325f49891bca8d375da
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEK10 DAB1 UGT8 LRBA

3.56e-041808349e09b3dfe344b5d50520711513d389865d73a861
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 ISLR ZNF229 PPIAL4G

3.63e-04181834b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

3.63e-04181834dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

3.71e-041828347ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

ERICH3 NEK10 SLC9C2 CFAP65

3.71e-04182834fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellmild-B_cell|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SREBF2 GSDMB UGT8 ZNF225

3.79e-04183834175aaf8fbbff52eab87d78a49d5ab02cd489c438
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

FAT4 RORB KLHL8 SVEP1

3.87e-0418483467164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

3.87e-041848345daff849625f2f41d56615569c0ed59cd733b34c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 DAB1 SVEP1 SEZ6

3.95e-04185834cefd81adb480c027545a5c78dcd05669783717f4
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERICH3 NEK10 FBXO15 CFAP65

3.95e-041858345e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellCOPD-Lymphoid-B|COPD / Disease state, Lineage and Cell class

SREBF2 UGT8 SNX9 MAP4K4

3.95e-04185834925e79c35c381dd44ec5fb921dca09ce43140135
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

3.95e-0418583430f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell18-Distal-Epithelial-Multiciliated_cell|Distal / Age, Tissue, Lineage and Cell class

ERICH3 NEK10 FBXO15 TSPAN1

4.11e-041878348d7fa6b2950898e7f283401808378ba2a41b9651
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

4.11e-041878349e10ed56090d82589bc457788282f664b70ace4b
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

4.19e-0418883461a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

4.19e-0418883434b11f72ca73153d02edcd09b38983ad1a504659
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

4.19e-041888342b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

4.28e-0418983468a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellControl-Epithelial-Ciliated|Control / Disease state, Lineage and Cell class

ERICH3 NEK10 TSPAN1 CFAP65

4.28e-04189834c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

ERICH3 NEK10 SLC9C2 CFAP65

4.28e-04189834b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCiliated|World / shred by cell class for parenchyma

ERICH3 NEK10 FBXO15 TSPAN1

4.28e-04189834711181ca3b9102fb155168b646b0a9b09ff215b2
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ERICH3 BCO2 NEK10 TSPAN1

4.36e-04190834a90a38fccdbf75a286b4d258fc54920c02b282f7
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERICH3 NEK10 TSPAN1 CFAP65

4.36e-041908342fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ERICH3 NEK10 FBXO15 TSPAN1

4.45e-04191834dad675251e129254955eac179c84a641a4864586
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ERICH3 NEK10 FBXO15 TSPAN1

4.45e-041918346d2cf41ee946137c039ddcc13593fc3f670afbba
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

DMXL2 FIG4 SYK PNPLA3

4.45e-04191834dab953682b8c9ed680a799161f837f792a7e4f33
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ERICH3 NEK10 TSPAN1 CFAP65

4.45e-04191834e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellnormal_Lung-Epithelial_cells-Ciliated|normal_Lung / Location, Cell class and cell subclass

ERICH3 NEK10 TSPAN1 CFAP65

4.54e-04192834097a13121820ab4e5cd2365600efccf5ea4ce8c3
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ERICH3 NEK10 TSPAN1 CFAP65

4.54e-0419283403acd4a26b986e34eee608747347791122f1aa52
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ERICH3 NEK10 TSPAN1 CFAP65

4.54e-0419283431c6046589e2fbb0486fd044c5b128099d37872f
ToppCellIPF-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

ERICH3 NEK10 TSPAN1 CFAP65

4.54e-04192834d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

ERICH3 NEK10 TSPAN1 CFAP65

4.54e-04192834eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellIPF-Epithelial-Ciliated|IPF / Disease state, Lineage and Cell class

ERICH3 NEK10 TSPAN1 CFAP65

4.54e-04192834354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERICH3 NEK10 TSPAN1 CFAP65

4.63e-04193834e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAT4 RORB ISLR SVEP1

4.63e-04193834cf2461af78f65616ce40d552ee9452295e3895ed
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERICH3 BCO2 NEK10 CFAP65

4.63e-04193834ea345d34440b25f65358a53dc72831998d1c3620
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAT4 RORB ISLR SVEP1

4.63e-041938346ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

ERICH3 NEK10 TSPAN1 CFAP65

4.63e-04193834a0baa8be6f590b2031fede22be588715ae458e93
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAT4 RORB ISLR SVEP1

4.63e-04193834e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCellwk_15-18-Epithelial-Proximal_epithelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ERICH3 NEK10 TSPAN1 CFAP65

4.72e-04194834b0477583301dc6d9767b667bd2f8f94fbfaa6f81
Diseasedisease of cellular proliferation (implicated_via_orthology)

TYK2 JAK3 TP53

5.05e-077733DOID:14566 (implicated_via_orthology)
DiseaseKeratosis Blennorrhagica

CAT TP53

6.01e-055732C0022594
DiseaseKeratosis

CAT TP53

6.01e-055732C0022593
DiseaseKeratoma

CAT TP53

6.01e-055732C0086501
Diseasetongue squamous cell carcinoma (biomarker_via_orthology)

JAK3 TP53

9.00e-056732DOID:0050865 (biomarker_via_orthology)
Diseasehoarding disorder

TLK2 NEK10 DAB1

9.78e-0536733EFO_0803361
Diseasesarcoma (is_implicated_in)

SREBF2 TP53

1.67e-048732DOID:1115 (is_implicated_in)
DiseaseGastric Adenocarcinoma

TLK2 JAK3 TRRAP

1.91e-0445733C0278701
Diseaseglioblastoma multiforme

POLR3B TP53

2.15e-049732EFO_0000519
Diseasepterygium (is_marker_for)

CAT TP53

2.15e-049732DOID:0002116 (is_marker_for)
Diseasemelanoma

FAT4 SYK CUBN TRRAP TP53

3.80e-04248735C0025202
DiseasePsoriasis

TYK2 CAT TP53

3.86e-0457733C0033860
DiseasePustulosis of Palms and Soles

TYK2 CAT TP53

3.86e-0457733C0030246
DiseaseB-Cell Lymphomas

JAK3 TP53

3.92e-0412732C0079731
DiseaseAmyotrophic Lateral Sclerosis

TARDBP FIG4 TP53

4.07e-0458733C0002736
Diseasehematologic cancer (implicated_via_orthology)

TYK2 JAK3

4.63e-0413732DOID:2531 (implicated_via_orthology)
Diseasecirrhosis of liver

PNPLA3 KLHL8

4.63e-0413732EFO_0001422
Diseaseneutrophil count

DNAJC13 PPIAL4D TTC39C RTCA GSDMB PNPLA3 LRBA DPP8 MAP4K4 TENT5B FANCA

5.63e-0413827311EFO_0004833
DiseaseNon-Small Cell Lung Carcinoma

TRMT11 CAT PPIA TP53

6.16e-04156734C0007131
Diseaseepilepsy (implicated_via_orthology)

CACNA1B MIB1 PPIA MAP4K4

7.26e-04163734DOID:1826 (implicated_via_orthology)
DiseaseAmyotrophic lateral sclerosis

TARDBP FIG4

8.02e-0417732cv:C0002736
DiseaseUterine leiomyoma, estrogen-receptor positive breast cancer

NEK10 TP53

9.00e-0418732EFO_1000649, HP_0000131
Diseaseessential hypertension (is_implicated_in)

GRK4 CAT

9.00e-0418732DOID:10825 (is_implicated_in)
Diseaseskin sensitivity to sun

RALY FANCA

1.00e-0319732EFO_0004795
Diseasehepatocellular carcinoma (is_implicated_in)

CAT PNPLA3 MAP4K4 TP53

1.07e-03181734DOID:684 (is_implicated_in)
DiseaseHodgkins lymphoma

CACNA1I ISLR PAPOLG

1.12e-0382733EFO_0000183
DiseaseMalignant neoplasm of breast

MICAL1 TMTC4 SREBF2 GSDMB TRMT11 CAT LRBA CUBN TP53

1.30e-031074739C0006142
Diseasecholelithiasis

PNPLA3 LRBA SNX9

1.37e-0388733EFO_0004799
Diseasenevus count, cutaneous melanoma

RALY TP53 FANCA

1.51e-0391733EFO_0000389, EFO_0004632
DiseaseAdenocarcinoma of large intestine

TYK2 TRRAP TP53

1.76e-0396733C1319315
Diseasetriacylglycerol 48:0 measurement

FIG4 RORB

1.89e-0326732EFO_0010403
Diseasecoronary artery disease (is_implicated_in)

PNPLA3 CUBN TP53

1.98e-03100733DOID:3393 (is_implicated_in)
DiseaseNeoplasm Metastasis

SREBF2 CAT PPIA TP53

2.08e-03217734C0027627
DiseaseSeizures

CACNA1B MIB1 CAT TRRAP

2.12e-03218734C0036572
DiseaseAmyotrophic Lateral Sclerosis With Dementia

TARDBP TP53

2.35e-0329732C0393554

Protein segments in the cluster

PeptideGeneStartEntry
LGGKRGYFGFVCVER

ERICH3

376

Q5RHP9
ERVVHAKGAGAFGYF

CAT

71

P04040
GEKRTFFGCRHYTTG

GSDMB

41

Q8TAX9
FGVFGKHCELNSYGF

FAT4

3966

Q6V0I7
RVFLSYCSLHGAQGG

DMXL2

2156

Q8TDJ6
GHYKFCELLIGRGAH

ANKRD17

1331

O75179
FYGCGFRHLVGDSLI

BCO2

481

Q9BYV7
ALGFVFHKGSYLRNG

CACNA1B

151

Q00975
GRVAGCSVHKGYAFV

RALY

46

Q9UKM9
NLGHGSFTKIYRGCR

JAK3

526

P52333
GKIFTFGSYRLGVHT

PAPOLB

96

Q9NRJ5
TGEKGFRYKGSCFHR

PPIAL4C

41

A0A0B4J2A2
QGFYCGVGLFTRFLK

DNAJC14

311

Q6Y2X3
GQRLKVIYGSCAGFH

MAP4K4

1081

O95819
NYLGGFALSVAHGRK

SYK

46

P43405
CLTVRARGHSYFAGF

CFAP65

756

Q6ZU64
GRRFHGKAVEGKGCY

ISLR

356

O14498
DEKGRYKRFHGAFSG

GPATCH1

41

Q9BRR8
ILDHLGSGAFGCVYK

NEK10

521

Q6ZWH5
GVSKLHGCLYVVGGF

KLHL8

501

Q9P2G9
CFRGEGSHGVILFLY

MINDY4B

251

A8MYZ0
PRLCYLVKEGGSHGF

PDZK1P1

11

A8MUH7
LCRLAKGENGYGFHL

PDZK1P1

261

A8MUH7
GFLGFYHVGATRCLS

PNPLA3

16

Q9NST1
LSFAACGFLGIYHLG

PNPLA4

6

P41247
HGYGIRLLGFDKQCS

DCAF10

491

Q5QP82
KGLGYSAHFVGGCLI

LRBA

261

P50851
ALASKGGTGRCYFHG

LMLN2

651

A0A1B0GTW7
RALGAKKFYGRFCTG

MICAL1

136

Q8TDZ2
LYRIMGNGFAGCVHF

MED25

486

Q71SY5
IGFCRENGFHGLVAY

FAM120A

171

Q9NZB2
SYGFRLGFLHSGTAK

TP53

106

P04637
TGEKGFRYKGSCFHR

PPIAL4F

41

P0DN26
LFHYCVGSGLAGREL

LHFPL4

61

Q7Z7J7
TGEKGFRYKGSCFHR

PPIAL4E

41

A0A075B759
AKGGSFYRDHCPVLG

MIB1

221

Q86YT6
FTLCRKLGSGYFGEV

PTK6

191

Q13882
TGEKGFRYKGSCFHR

PPIAL4D

41

F5H284
TGEKGFRYKGSCFHR

PPIAL4H

41

A0A075B767
IHGAVFGKGTYFARD

PARP11

226

Q9NR21
ACIYTRKGVFFAGGT

NPAS4

46

Q8IUM7
IFTFGSYRLGVHTKG

PAPOLG

96

Q9BWT3
TGEKGFRYKGSCFHR

PPIAL4A

41

Q9Y536
TGEKGFRYKGSCFHR

PPIAL4G

41

P0DN37
RAGFNASFHKSCGGY

CUBN

2081

O60494
FGFKFSYRIISCGGV

CUBN

3026

O60494
LGRVAFFVGGYCVSK

HSD17B6

166

O14756
FGYVCGKEGNHRFVA

DAB1

126

O75553
HSGGVFYLCGTFRNL

FBXO15

361

Q8NCQ5
IHGFCGQSKLLIYGR

FIG4

251

Q92562
FGSTRGYHGCSKKAL

FANCA

456

O15360
GILGVQLFKGKFYHC

CACNA1I

1321

Q9P0X4
GTFLFQAGSGIYHVK

DPP8

176

Q6V1X1
GSCHRGLKFEGAFKY

DPP8

706

Q6V1X1
HGFVLVSFGAGVKYL

UGT8

286

Q16880
QGGFCILYGGFSRLH

DNAJC13

166

O75165
TFRHYRVLGKGGFGE

GRK4

186

P32298
KVGRFGIGFNSVYHI

SACS

186

Q9NZJ4
AGHIFLGFSKCGRYV

DCAF15

76

Q66K64
DGKLYVCGGFHGADR

KBTBD12

551

Q3ZCT8
YKGFLGCFPDIIGTH

SNX9

496

Q9Y5X1
TGGLLIACAHFGAYV

TRMT11

226

Q7Z4G4
TGEKGFGYKGSCFHR

PPIA

41

P62937
TGHSKGFGFVRFTEY

TARDBP

141

Q13148
AGGKYKAFSICGSHL

OR7G3

231

Q8NG95
GSTVKYSCVGGFFLR

SVEP1

2401

Q4LDE5
GGGLLKYCHLLVRGF

TENT5B

276

Q96A09
HLLGRGGFSEVYKAF

TLK2

466

Q86UE8
YCVLLTFGFGALSKH

TMTC4

421

Q5T4D3
IHYGVITCEGCKGFF

RORC

41

P51449
FGGYGRSCLHIKRDK

ZNF577

111

Q9BSK1
RGCVTKIYGRAFVAG

RTCA

186

O00442
TRCGGKLGFLASYFL

SREBF2

726

Q12772
IHYGVITCEGCKGFF

RORB

31

Q92753
ILGKGFFAAYEATCG

TLL2

451

Q9Y6L7
GGSARFHCATGYQLK

SEZ6

376

Q53EL9
GRFHYGTAFGGSKVK

POLR3B

956

Q9NW08
ECGKGFRYGSGLLSH

ZNF229

716

Q9UJW7
QCGKGFSRRSGLYVH

ZNF225

236

Q9UK10
EHLIYAFFGIVIGCG

SLC9C2

311

Q5TAH2
AFFGIVIGCGELSHY

SLC9C2

316

Q5TAH2
KGAVSFGYGLFHLCI

TTC39C

216

Q8N584
LFSVIIHKGGCYGGH

USP40

291

Q9NVE5
HLGSCTLGNFVAGKY

ZNF512

426

Q96ME7
SISHVAYRVLGKFGG

TRRAP

886

Q9Y4A5
FGHFKFCITLFGGYV

SLC35E3

256

Q7Z769
RDLGEGHFGKVSLYC

TYK2

901

P29597
VVFALGFLGCYGAKT

TSPAN1

66

O60635
GCKFLLYAHRVGRGV

VN1R2

161

Q8NFZ6