| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | transmembrane transporter activity | ABCC11 ZACN SLC22A25 GRIN1 DCD RYR2 SLC44A3 ABCB8 SCN5A SLC5A2 | 6.58e-05 | 1180 | 39 | 10 | GO:0022857 |
| GeneOntologyMolecularFunction | calmodulin binding | 8.12e-05 | 230 | 39 | 5 | GO:0005516 | |
| GeneOntologyMolecularFunction | transporter activity | ABCC11 ZACN SLC22A25 GRIN1 DCD RYR2 SLC44A3 ABCB8 SCN5A SLC5A2 | 1.37e-04 | 1289 | 39 | 10 | GO:0005215 |
| GeneOntologyMolecularFunction | phosphatidylinositol-3,5-bisphosphate phosphatase activity | 4.38e-04 | 16 | 39 | 2 | GO:0106018 | |
| GeneOntologyMolecularFunction | phosphatidylinositol bisphosphate phosphatase activity | 1.27e-03 | 27 | 39 | 2 | GO:0034593 | |
| GeneOntologyMolecularFunction | phosphatidylinositol phosphate phosphatase activity | 1.56e-03 | 30 | 39 | 2 | GO:0052866 | |
| GeneOntologyMolecularFunction | ligand-gated calcium channel activity | 1.67e-03 | 31 | 39 | 2 | GO:0099604 | |
| GeneOntologyMolecularFunction | monoatomic ion channel activity | 1.90e-03 | 459 | 39 | 5 | GO:0005216 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic cation channel activity | 2.56e-03 | 140 | 39 | 3 | GO:0099094 | |
| GeneOntologyMolecularFunction | channel activity | 3.39e-03 | 525 | 39 | 5 | GO:0015267 | |
| GeneOntologyMolecularFunction | passive transmembrane transporter activity | 3.42e-03 | 526 | 39 | 5 | GO:0022803 | |
| GeneOntologyMolecularFunction | monoatomic ion transmembrane transporter activity | 4.10e-03 | 793 | 39 | 6 | GO:0015075 | |
| GeneOntologyMolecularFunction | ABC-type transporter activity | 4.13e-03 | 49 | 39 | 2 | GO:0140359 | |
| GeneOntologyMolecularFunction | monoatomic cation channel activity | 4.38e-03 | 343 | 39 | 4 | GO:0005261 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic ion channel activity | 6.29e-03 | 193 | 39 | 3 | GO:0015276 | |
| GeneOntologyMolecularFunction | 3'-5' exonuclease activity | 6.33e-03 | 61 | 39 | 2 | GO:0008408 | |
| GeneOntologyMolecularFunction | exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 6.53e-03 | 62 | 39 | 2 | GO:0016796 | |
| GeneOntologyMolecularFunction | ligand-gated channel activity | 6.66e-03 | 197 | 39 | 3 | GO:0022834 | |
| GeneOntologyMolecularFunction | carboxylic acid transmembrane transporter activity | 7.63e-03 | 207 | 39 | 3 | GO:0046943 | |
| GeneOntologyMolecularFunction | organic acid transmembrane transporter activity | 7.73e-03 | 208 | 39 | 3 | GO:0005342 | |
| GeneOntologyBiologicalProcess | Purkinje myocyte to ventricular cardiac muscle cell communication | 5.47e-05 | 6 | 40 | 2 | GO:0086068 | |
| GeneOntologyBiologicalProcess | Purkinje myocyte to ventricular cardiac muscle cell signaling | 5.47e-05 | 6 | 40 | 2 | GO:0086029 | |
| GeneOntologyBiologicalProcess | SA node cell to atrial cardiac muscle cell signaling | 1.63e-04 | 10 | 40 | 2 | GO:0086018 | |
| GeneOntologyBiologicalProcess | SA node cell action potential | 1.63e-04 | 10 | 40 | 2 | GO:0086015 | |
| GeneOntologyBiologicalProcess | SA node cell to atrial cardiac muscle cell communication | 1.99e-04 | 11 | 40 | 2 | GO:0086070 | |
| GeneOntologyBiologicalProcess | monoatomic ion transport | ABCC11 ZACN SLC22A25 GRIN1 DCD F2RL3 RYR2 ABCB8 SCN5A SLC5A2 | 2.23e-04 | 1374 | 40 | 10 | GO:0006811 |
| GeneOntologyBiologicalProcess | monoatomic ion transmembrane transport | 2.28e-04 | 1115 | 40 | 9 | GO:0034220 | |
| GeneOntologyBiologicalProcess | AV node cell to bundle of His cell signaling | 2.39e-04 | 12 | 40 | 2 | GO:0086027 | |
| GeneOntologyBiologicalProcess | AV node cell action potential | 2.39e-04 | 12 | 40 | 2 | GO:0086016 | |
| GeneOntologyBiologicalProcess | AV node cell to bundle of His cell communication | 3.79e-04 | 15 | 40 | 2 | GO:0086067 | |
| MousePheno | abnormal myocardial fiber sodium currents | 6.43e-09 | 3 | 27 | 3 | MP:0020347 | |
| MousePheno | abnormal myocardial fiber currents | 5.36e-07 | 9 | 27 | 3 | MP:0020345 | |
| MousePheno | abnormal myocardial fiber calcium currents | 1.08e-05 | 3 | 27 | 2 | MP:0020346 | |
| MousePheno | thick ventricular wall | 2.63e-05 | 91 | 27 | 4 | MP:0002953 | |
| MousePheno | ventricular fibrillation | 7.50e-05 | 7 | 27 | 2 | MP:0006110 | |
| MousePheno | atrial fibrillation | 1.60e-04 | 10 | 27 | 2 | MP:0008543 | |
| MousePheno | prolonged P wave | 2.34e-04 | 12 | 27 | 2 | MP:0004071 | |
| MousePheno | fibrillation | 3.22e-04 | 14 | 27 | 2 | MP:0006109 | |
| MousePheno | reduced male mating frequency | 3.71e-04 | 15 | 27 | 2 | MP:0001380 | |
| MousePheno | abnormal copulatory plug deposition | 4.24e-04 | 16 | 27 | 2 | MP:0030982 | |
| MousePheno | abnormal offspring retrieval | 4.80e-04 | 17 | 27 | 2 | MP:0009731 | |
| MousePheno | pup cannibalization | 4.80e-04 | 17 | 27 | 2 | MP:0001385 | |
| MousePheno | abnormal pup retrieval | 4.80e-04 | 17 | 27 | 2 | MP:0001384 | |
| MousePheno | sinoatrial block | 5.39e-04 | 18 | 27 | 2 | MP:0010520 | |
| MousePheno | abnormal heart ventricle morphology | 6.01e-04 | 793 | 27 | 7 | MP:0005294 | |
| Domain | ABC_membrane | 1.03e-03 | 24 | 37 | 2 | PF00664 | |
| Domain | ABC_TM1F | 1.40e-03 | 28 | 37 | 2 | PS50929 | |
| Domain | ABC1_TM_dom | 1.40e-03 | 28 | 37 | 2 | IPR011527 | |
| Domain | ABC_transporter_CS | 3.13e-03 | 42 | 37 | 2 | IPR017871 | |
| Domain | ABC_TRANSPORTER_2 | 4.07e-03 | 48 | 37 | 2 | PS50893 | |
| Domain | ABC_tran | 4.07e-03 | 48 | 37 | 2 | PF00005 | |
| Domain | ABC_TRANSPORTER_1 | 4.24e-03 | 49 | 37 | 2 | PS00211 | |
| Domain | ABC_transporter-like | 4.41e-03 | 50 | 37 | 2 | IPR003439 | |
| Domain | - | 9.43e-03 | 74 | 37 | 2 | 3.40.50.410 | |
| Domain | IGv | 9.68e-03 | 75 | 37 | 2 | SM00406 | |
| Domain | SPRY | 1.29e-02 | 87 | 37 | 2 | SM00449 | |
| Domain | SPRY | 1.49e-02 | 94 | 37 | 2 | PF00622 | |
| Domain | SPRY_dom | 1.49e-02 | 94 | 37 | 2 | IPR003877 | |
| Domain | B30.2/SPRY | 1.52e-02 | 95 | 37 | 2 | IPR001870 | |
| Domain | B302_SPRY | 1.52e-02 | 95 | 37 | 2 | PS50188 | |
| Pathway | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | 1.57e-04 | 10 | 27 | 2 | MM14644 | |
| Pathway | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | 1.92e-04 | 11 | 27 | 2 | M655 | |
| Pathway | REACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS | 2.30e-04 | 12 | 27 | 2 | M27738 | |
| Pathway | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | 3.65e-04 | 15 | 27 | 2 | MM14643 | |
| Pathway | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | 4.17e-04 | 16 | 27 | 2 | M639 | |
| Pubmed | 1.29e-06 | 2 | 40 | 2 | 23723061 | ||
| Pubmed | Genetic analysis in post-mortem samples with micro-ischemic alterations. | 1.29e-06 | 2 | 40 | 2 | 28086167 | |
| Pubmed | The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression. | 1.29e-06 | 2 | 40 | 2 | 32973333 | |
| Pubmed | Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3. | 1.29e-06 | 2 | 40 | 2 | 26289036 | |
| Pubmed | 3.87e-06 | 3 | 40 | 2 | 22767497 | ||
| Pubmed | 3.87e-06 | 3 | 40 | 2 | 32713021 | ||
| Pubmed | 4.53e-06 | 28 | 40 | 3 | 24483146 | ||
| Pubmed | 7.73e-06 | 4 | 40 | 2 | 26862996 | ||
| Pubmed | 7.73e-06 | 4 | 40 | 2 | 18429927 | ||
| Pubmed | 7.73e-06 | 4 | 40 | 2 | 29306897 | ||
| Pubmed | Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2. | 7.73e-06 | 4 | 40 | 2 | 39142074 | |
| Pubmed | 1.29e-05 | 5 | 40 | 2 | 29339503 | ||
| Pubmed | PtdIns5P regulation through evolution: roles in membrane trafficking? | 1.93e-05 | 6 | 40 | 2 | 18774718 | |
| Pubmed | The cluster of BTN genes in the extended major histocompatibility complex. | 2.70e-05 | 7 | 40 | 2 | 11170752 | |
| Pubmed | Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction. | 5.77e-05 | 10 | 40 | 2 | 32672536 | |
| Pubmed | 5.77e-05 | 10 | 40 | 2 | 26897459 | ||
| Pubmed | 5.77e-05 | 10 | 40 | 2 | 18434328 | ||
| Pubmed | Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models. | 7.05e-05 | 11 | 40 | 2 | 27766308 | |
| Pubmed | 1.53e-04 | 16 | 40 | 2 | 35044906 | ||
| Pubmed | A 1.1-Mb transcript map of the hereditary hemochromatosis locus. | 1.95e-04 | 18 | 40 | 2 | 9149941 | |
| Pubmed | 2.18e-04 | 19 | 40 | 2 | 24564958 | ||
| Pubmed | 2.42e-04 | 20 | 40 | 2 | 34127677 | ||
| Pubmed | Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit. | 2.67e-04 | 21 | 40 | 2 | 28302382 | |
| Pubmed | 4.78e-04 | 28 | 40 | 2 | 23006423 | ||
| Pubmed | 7.07e-04 | 34 | 40 | 2 | 26378152 | ||
| Pubmed | 8.64e-04 | 162 | 40 | 3 | 15174051 | ||
| Pubmed | 8.83e-04 | 38 | 40 | 2 | 38196272 | ||
| Pubmed | Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. | 8.83e-04 | 38 | 40 | 2 | 27098205 | |
| Cytoband | 11q24.2 | 2.35e-05 | 63 | 40 | 3 | 11q24.2 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr11q24 | 6.25e-04 | 191 | 40 | 3 | chr11q24 | |
| Cytoband | 17q25.3 | 3.54e-03 | 101 | 40 | 2 | 17q25.3 | |
| Cytoband | 9q34.3 | 3.89e-03 | 106 | 40 | 2 | 9q34.3 | |
| GeneFamily | Butyrophilins|V-set domain containing|C2-set domain containing | 2.23e-04 | 15 | 27 | 2 | 458 | |
| GeneFamily | Solute carriers | 2.05e-02 | 395 | 27 | 3 | 752 | |
| GeneFamily | Adenosine receptors|V-set domain containing | 2.45e-02 | 163 | 27 | 2 | 590 | |
| ToppCell | wk_15-18-Hematologic-Myeloid-Mast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung | 1.69e-05 | 172 | 40 | 4 | a7146c255031207e64682ef767884b11c96e0d59 | |
| ToppCell | facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 2.30e-05 | 186 | 40 | 4 | 337f768cc43db2db96ba6495b076006b1a5b0331 | |
| ToppCell | facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 2.30e-05 | 186 | 40 | 4 | e378c82ef6d6cb24751515aa499a01372b3e7ccf | |
| ToppCell | facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 2.45e-05 | 189 | 40 | 4 | b98f60875b1a12b2ec9dc91889298ae57f98602f | |
| ToppCell | facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 2.45e-05 | 189 | 40 | 4 | e758b264c0a47127e33e66c395cf5a3224c7305b | |
| ToppCell | facs-Heart-LV-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 2.55e-05 | 191 | 40 | 4 | 9d7d680da3979e256191b534ebd14c5383e0cf93 | |
| ToppCell | facs-Heart-LV-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 2.55e-05 | 191 | 40 | 4 | 543da1197c7e62f2c9cbd4a51414bbaaa6d1a92f | |
| ToppCell | Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic | 3.05e-05 | 200 | 40 | 4 | 1d67c5d2c617749b521e70879950dea2c9d076d6 | |
| ToppCell | Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20|Neuronal / cells hierarchy compared to all cells using T-Statistic | 3.05e-05 | 200 | 40 | 4 | 26c7f2b0afe9e50f2a5c43918ad8e91d7553b72c | |
| Computational | Neighborhood of CASP8 | 2.76e-05 | 27 | 24 | 3 | GNF2_CASP8 | |
| Computational | Neighborhood of SNRK | 3.09e-05 | 28 | 24 | 3 | GNF2_SNRK | |
| Computational | Neighborhood of ITGAL | 2.38e-04 | 55 | 24 | 3 | GNF2_ITGAL | |
| Drug | Meglumine [6284-40-8]; Up 200; 20.4uM; HL60; HT_HG-U133A | 9.31e-07 | 200 | 38 | 6 | 3068_UP | |
| Drug | Salbutamol [18559-94-9]; Up 200; 16.8uM; PC3; HT_HG-U133A | 1.43e-05 | 187 | 38 | 5 | 3677_UP | |
| Drug | 17-AAG; Up 200; 1uM; PC3; HT_HG-U133A | 1.58e-05 | 191 | 38 | 5 | 4442_UP | |
| Drug | AC1MO44G | 1.66e-05 | 92 | 38 | 4 | CID003363161 | |
| Drug | Fluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A | 1.79e-05 | 196 | 38 | 5 | 7348_DN | |
| Drug | Merbromin [129-16-8]; Up 200; 5uM; PC3; HT_HG-U133A | 1.79e-05 | 196 | 38 | 5 | 3700_UP | |
| Drug | Benzylpenicillin sodium [69-57-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A | 1.83e-05 | 197 | 38 | 5 | 3577_UP | |
| Drug | CGX 0596987; Up 200; 20uM; MCF7; HT_HG-U133A | 1.83e-05 | 197 | 38 | 5 | 6412_UP | |
| Drug | Hydroflumethiazide [135-09-1]; Up 200; 12uM; PC3; HT_HG-U133A | 1.83e-05 | 197 | 38 | 5 | 7259_UP | |
| Drug | Salsolinol hydrobromide [38221-21-5]; Up 200; 15.4uM; MCF7; HT_HG-U133A | 1.88e-05 | 198 | 38 | 5 | 4816_UP | |
| Drug | estradiol dipropionate | 2.70e-05 | 5 | 38 | 2 | ctd:C023482 | |
| Disease | Arrhythmogenic Right Ventricular Dysplasia | 4.84e-06 | 3 | 38 | 2 | C0349788 | |
| Disease | Tachycardia, Ventricular | 8.82e-05 | 11 | 38 | 2 | C0042514 | |
| Disease | Long QT Syndrome | 8.82e-05 | 11 | 38 | 2 | C0023976 | |
| Disease | BRCAX breast cancer | 3.02e-04 | 20 | 38 | 2 | EFO_0009443 | |
| Disease | colorectal health | 2.20e-03 | 201 | 38 | 3 | EFO_0008460 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| SLSLLLHCIMFNMRS | 541 | Q14146 | |
| FMTLLAMSLQNLKTL | 11 | Q8IVU9 | |
| MKMASSLAFLLLNFH | 1 | O00478 | |
| MNRFLLLMSLYLLGS | 1 | P26436 | |
| SSMARALVLLQSMAS | 61 | Q2M243 | |
| MRKMNTLLLVSLSFL | 1 | P0C8F1 | |
| LMKSFLSVFRSLAML | 76 | Q99638 | |
| LFLKQRMSLLSQMTS | 381 | Q96NW4 | |
| MRVLSGTSLMLCSLL | 1 | P21941 | |
| LSSLLSLLLFAGMQM | 11 | Q8N6L1 | |
| DMLLATSSRFRMMNL | 426 | P03372 | |
| MAFSMLASLNLLRLS | 416 | Q96J66 | |
| MRFMTLLFLTALAGA | 1 | P81605 | |
| SLSMCLLLQSFVLMI | 11 | Q96PB8 | |
| MSNASLLTAFILMGL | 1 | Q8NGN5 | |
| STMLLMNLAAADLLL | 111 | Q96RI0 | |
| MMALLQQLLHSDSLS | 616 | Q9Y2I7 | |
| SLLQLFRSINDMMSS | 771 | Q14185 | |
| MNSKRMLLLVLFAFS | 1 | Q7Z4J2 | |
| RLLRSMATQAMSNAL | 756 | Q8TF46 | |
| MKMASSLAFLLLNFH | 1 | P78410 | |
| LALALSLAMMFTFRF | 221 | Q8N4M1 | |
| RLSQMLLMFLLATCL | 406 | Q6T423 | |
| FALRYNILTLMRMLS | 4246 | Q92736 | |
| LSLRNMGLHSSFMAL | 516 | Q86YC3 | |
| SLSMLSTRLTLLLMV | 286 | Q9NUT2 | |
| TNMLLELARSLFNRM | 21 | Q9P0P0 | |
| MAATSLMSALAARLL | 1 | P13995 | |
| LLANMAVDRSMTASL | 846 | O95486 | |
| LSLMELGLSRMSNLS | 791 | Q14524 | |
| MYLKSSDNRLLMSLF | 726 | Q92854 | |
| FAAMLFLFSMATLLR | 71 | Q9Y397 | |
| RTAQLTSLAMLMLDS | 381 | Q13496 | |
| MLAALMSSLASIFNS | 386 | P31639 | |
| ISMLAMLFTLSGLRA | 6 | A0A0B4J244 | |
| ILRYTMSSMLLLRLS | 76 | Q401N2 | |
| MTSLMDLTLLLARSQ | 876 | Q9BTW9 | |
| MRIMLLFTAILAFSL | 1 | Q9UHF0 | |
| LLAAMQSLRMATAEA | 1051 | Q702N8 | |
| MSTMRLLTLALLFSC | 1 | Q05586 |