Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF486 ZFP69B ZNF91 APP ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	1.80e-05	1459	40	12	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ADNP2 ZNF486 ZFP69B ZNF91 ZFP69 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	7.26e-05	1412	40	11	GO:0000981
Domain	KRAB	ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426	3.00e-09	358	40	10	PS50805
Domain	ZINC_FINGER_C2H2_2	ADNP2 ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	4.58e-08	775	40	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ADNP2 ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	4.71e-08	777	40	12	PS00028
Domain	KRAB	ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF426	5.12e-08	358	40	9	PF01352
Domain	Znf_C2H2-like	ADNP2 ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	6.14e-08	796	40	12	IPR015880
Domain	KRAB	ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF426	6.63e-08	369	40	9	SM00349
Domain	KRAB	ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF426	6.78e-08	370	40	9	IPR001909
Domain	Znf_C2H2	ADNP2 ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	6.94e-08	805	40	12	IPR007087
Domain	ZnF_C2H2	ADNP2 ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	7.23e-08	808	40	12	SM00355
Domain	-	ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	1.19e-07	679	40	11	3.30.160.60
Domain	zf-C2H2	ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	1.47e-07	693	40	11	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426 PRDM2	1.49e-07	694	40	11	IPR013087
Domain	zf-C2H2_6	ZNF486 ZFP69B ZNF91 ZNF649 ZNF25 ZNF426 PRDM2	4.11e-06	314	40	7	PF13912
Domain	-	NBAS SPAG9 AHI1 WDR76 DENND3 WDTC1	7.07e-05	333	40	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	NBAS SPAG9 AHI1 WDR76 DENND3 WDTC1	7.31e-05	335	40	6	IPR015943
Domain	WD_REPEATS_1	NBAS AHI1 WDR76 DENND3 WDTC1	3.03e-04	278	40	5	PS00678
Domain	WD_REPEATS_2	NBAS AHI1 WDR76 DENND3 WDTC1	3.08e-04	279	40	5	PS50082
Domain	WD_REPEATS_REGION	NBAS AHI1 WDR76 DENND3 WDTC1	3.08e-04	279	40	5	PS50294
Domain	WD40_repeat_dom	SPAG9 AHI1 WDR76 DENND3 WDTC1	4.10e-04	297	40	5	IPR017986
Domain	Olfact_rcpt	OR2C3 OR51L1 OR51B6 OR14A16 OR10J3	1.44e-03	393	40	5	IPR000725
Domain	WD40	AHI1 WDR76 DENND3 WDTC1	2.23e-03	259	40	4	PF00400
Domain	WD40	AHI1 WDR76 DENND3 WDTC1	2.52e-03	268	40	4	SM00320
Domain	WD40_repeat	AHI1 WDR76 DENND3 WDTC1	2.66e-03	272	40	4	IPR001680
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	DCLK3 PRKAA2	9.58e-03	69	40	2	IPR020636
Domain	GPCR_Rhodpsn_7TM	OR2C3 OR51L1 OR51B6 OR14A16 OR10J3	1.36e-02	670	40	5	IPR017452
Domain	7tm_1	OR2C3 OR51L1 OR51B6 OR14A16 OR10J3	1.42e-02	677	40	5	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2C3 OR51L1 OR51B6 OR14A16 OR10J3	1.49e-02	685	40	5	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2C3 OR51L1 OR51B6 OR14A16 OR10J3	1.54e-02	691	40	5	PS50262
Domain	GPCR_Rhodpsn	OR2C3 OR51L1 OR51B6 OR14A16 OR10J3	1.55e-02	692	40	5	IPR000276
Pubmed	Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.	ZNF91 ZNF268	4.62e-05	9	40	2	23665872
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF486 ZNF91 ZNF649 ZNF25	5.60e-05	181	40	4	37372979
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZFP69 ZNF426	2.42e-04	20	40	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZFP69 ZNF426	2.42e-04	20	40	2	2542606
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ADNP2 WDR76 ZNF649 ATAD2B PRDM2	6.37e-04	608	40	5	36089195
Pubmed	High-resolution recombinational map of mouse chromosome 16.	APP CD86	6.66e-04	33	40	2	9244437
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	WDR76 WDTC1	9.79e-04	40	40	2	25011449
Cytoband	1p34.2	ZFP69B ZFP69	1.15e-03	57	40	2	1p34.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ADNP2 ZNF486 ZFP69B ZNF91 ZFP69 ZNF649 ZNF25 ZNF268 ZNF559 ZNF774 ZNF426	3.12e-08	718	33	11	28
GeneFamily	WD repeat domain containing	AHI1 WDR76 DENND3 WDTC1	1.27e-03	262	33	4	362
GeneFamily	Olfactory receptors, family 51	OR51L1 OR51B6	2.91e-03	44	33	2	164
Coexpression	WEIGEL_OXIDATIVE_STRESS_RESPONSE	ZNF91 APP CASK	1.61e-05	33	39	3	M14591
Coexpression	YAGI_AML_WITH_T_8_21_TRANSLOCATION	NT5C2 ADNP2 NBAS PROZ ZNF91 APP	1.72e-05	372	39	6	M19261
Disease	Vertigo	CCDC60 AHI1 ZNF91 PRDM2	3.41e-05	139	39	4	HP_0002321
Disease	Cerebellar Diseases	AHI1 CASK	3.56e-05	7	39	2	C0007760
Disease	Large cell carcinoma of lung	DCLK3 CASK	8.23e-04	32	39	2	C0345958
Disease	selective IgA deficiency disease	AHI1 CD86	1.70e-03	46	39	2	EFO_1001929
Disease	obesity (implicated_via_orthology)	NT5C2 PRKAA2 WDTC1	2.87e-03	215	39	3	DOID:9970 (implicated_via_orthology)
Disease	HETE measurement	OR2C3 NBAS	3.06e-03	62	39	2	EFO_0801166
Disease	Cerebrovascular accident	APP PRKAA2	3.06e-03	62	39	2	C0038454
Disease	Cardiomyopathies, Primary	APP PRKAA2	3.78e-03	69	39	2	C0033141
Disease	Myocardial Diseases, Secondary	APP PRKAA2	3.78e-03	69	39	2	C0036529
Disease	middle cerebral artery infarction (biomarker_via_orthology)	APP CD86	6.75e-03	93	39	2	DOID:3525 (biomarker_via_orthology)
Disease	obesity (is_marker_for)	AHI1 APP	7.92e-03	101	39	2	DOID:9970 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
THVHTPHTQMHTRIL	nan	96	Q6ZRP5
MTIISVTLEIHHHIT	AGAP11	1	Q8TF27
HVLMPHESTVEHTHV	NT5C2	481	P49902
QHTLKHFEHVRMVDP	APP	506	P05067
ISHPMVKIHVVDEHT	AHI1	361	Q8N157
HRHMVVHRDLKPENV	PRKAA2	131	P54646
IIHHKKPTGMIRIHQ	CD86	111	P42081
HLHVTHRRMVVSMPN	DENND3	461	A2RUS2
ELHLKERHHIMPTVH	ADNP2	891	Q6IQ32
ERHHIMPTVHTVLKS	ADNP2	896	Q6IQ32
ALTIDHTHHTMKPVI	CCDC60	166	Q8IWA6
PHHSIRCMTVVHDKV	SPAG9	1046	O60271
MRSHGPTHSLVIHDV	OBSL1	1856	O75147
REASICHMLKHPHIV	CASK	61	O14936
SHHIHALKEMVVFPL	ATAD2B	406	Q9ULI0
VHMHDKSIVHRDLKP	DCLK3	466	Q9C098
RFGKHVPHVVHITMS	OR51B6	261	Q9H340
SMVHRFGKHLSPIVH	OR51L1	261	Q8NGJ5
IILVSHTDVHLHTPM	OR2C3	46	Q8N628
IKMVTRHVTRHEHEA	NBAS	1606	A2RRP1
VKHHMILPHTRSSDL	FASTKD5	576	Q7L8L6
MIHQRRKILSHTEEH	HACD2	236	Q6Y1H2
TKQGLERHMHIHIST	PRDM2	371	Q13029
FVHNVMSIPHHIIVK	MTERF3	336	Q96E29
IMTIIRLDHHLHTPM	OR10J3	46	Q5JRS4
VLIIMITTLDHHLHT	OR14A16	41	Q8NHC5
SQDPLMIKITHVHVH	PROZ	236	P22891
VHVHDLTVKETIHMF	WDTC1	116	Q8N5D0
LIIHMRTHTGEKPHE	ZNF268	711	Q14587
RKPHLIMHQRTHTGE	ZNF774	246	Q6NX45
MHHPCISVREKEHIL	SLC17A2	236	O00624
HPLHVEVLHSEIMAH	UBR1	296	Q8IWV7
QPSHLTTHKRMHTGE	ZNF91	921	Q05481
SVHTVAHIHEMKAEI	TTC38	216	Q5R3I4
SHLTVHQRMHTGEKP	ZNF25	271	P17030
LIHLTEHMRIHTGEK	ZFP69B	291	Q9UJL9
SSMGKIRTVHVHPVH	WDR76	446	Q9H967
SHLTVHMRTHTGEKP	ZNF559	366	Q9BR84
RSSHLTMHKIIHTGE	ZNF486	361	Q96H40
THLKIHMRIHTGEKP	ZNF426	461	Q9BUY5
KQPIHLTEHMRIHTG	ZFP69	281	Q49AA0
FLTKTMLIVHHRTHT	ZNF649	411	Q9BS31