Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-10 CSDE1 ERVK-8 ERVK-11

1.38e-09211126GO:0035613
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

2.28e-09111125GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

9.76e-09141125GO:0003964
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

1.92e-06371125GO:0016891
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-25

1.92e-06371125GO:0004190
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

2.20e-06381125GO:0034061
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-25

2.20e-06381125GO:0070001
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 USP9X PIDD1 ERVK-7 ERVK-10 F12 ADAMTS9 GZMH ERVK-8 PAPPA ERVK-25 ADAMTSL2

5.40e-0643011212GO:0004175
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

5.79e-06461125GO:0016893
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 MARF1 PAN3 ERVK-11

1.16e-051361127GO:0004540
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

HCN1 CLCN4 KCNB1 P2RX5 KCNG1 KCNG4 KCNAB3

7.54e-051821127GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

HCN1 CLCN4 KCNB1 P2RX5 KCNG1 KCNG4 KCNAB3

8.07e-051841127GO:0022832
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

8.22e-05791125GO:0004521
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 ERVK-7 ERVK-10 SIRT6 ERVK-8 ERVK-11

2.17e-041521126GO:0016779
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN1 KCNB1 KCNG1 KCNG4 KCNAB3

2.74e-041021125GO:0005249
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 USP9X PIDD1 ERVK-7 ERVK-10 F12 ADAMTS9 GZMH ERVK-8 PAPPA ERVK-25 ADAMTSL2

3.07e-0465411212GO:0008233
GeneOntologyMolecularFunctionnuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 MARF1 PAN3 ERVK-11

3.28e-042311127GO:0004518
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNB1 KCNG1 KCNG4

5.08e-04281123GO:0005251
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYH2 MYH3 MYO5B KIF13A DYNC1H1

5.37e-041181125GO:0003774
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-6 MRM1 ERVK-7 ERVK-10 TRMT44 ERVK-8 MARF1 PAN3 ERVK-11

5.72e-044171129GO:0140098
GeneOntologyMolecularFunctiongated channel activity

HCN1 CLCN4 KCNB1 P2RX5 KCNG1 KCNG4 SCNN1D KCNAB3

5.93e-043341128GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPC4AP HCN1 KCNB1 P2RX5 KCNG1 KCNG4 SCNN1D KCNAB3

7.06e-043431128GO:0005261
GeneOntologyMolecularFunctionpotassium channel activity

HCN1 KCNB1 KCNG1 KCNG4 KCNAB3

7.76e-041281125GO:0005267
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

1.02e-031361125GO:0004519
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TRPC4AP HCN1 CLCN4 KCNB1 P2RX5 KCNG1 KCNG4 SCNN1D KCNAB3

1.13e-034591129GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPC4AP HCN1 SLC34A3 SLC6A9 KCNB1 KCNG1 KCNG4 SCNN1D KCNAB3

1.23e-034651129GO:0046873
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH2 MYH3 MYO5B

1.26e-03381123GO:0000146
GeneOntologyMolecularFunctiondeacetylase activity

HDAC5 AMDHD2 SIRT6

1.46e-03401123GO:0019213
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

HCN1 KCNB1 KCNG1 KCNG4 KCNAB3

1.67e-031521125GO:0022843
GeneOntologyMolecularFunctiontransporter activity

ABCA2 TRPC4AP ESYT1 HCN1 SLC34A3 ATP10D CIDEA SLC6A9 ABCG4 CLCN4 KCNB1 P2RX5 KCNG1 KCNG4 SCNN1D KCNAB3

2.22e-03128911216GO:0005215
GeneOntologyMolecularFunctionATP-dependent activity

MYH2 MYH3 ABCA2 ERCC6 MYO5B ATP10D ACSL3 ABCG4 KIF13A DYNC1H1

2.39e-0361411210GO:0140657
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

HCN1 KCNB1 KCNG1 KCNG4 KCNAB3

2.52e-031671125GO:0015079
GeneOntologyMolecularFunctionchannel activity

TRPC4AP HCN1 CLCN4 KCNB1 P2RX5 KCNG1 KCNG4 SCNN1D KCNAB3

2.81e-035251129GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

TRPC4AP HCN1 CLCN4 KCNB1 P2RX5 KCNG1 KCNG4 SCNN1D KCNAB3

2.84e-035261129GO:0022803
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-6 ERCC6 MRM1 ERVK-7 ERVK-10 TRMT44 ERVK-8 MARF1 PAN3 ERVK-11

3.40e-0364511210GO:0140640
GeneOntologyMolecularFunctionATP hydrolysis activity

MYH3 ABCA2 ERCC6 MYO5B ATP10D ABCG4 KIF13A DYNC1H1

3.42e-034411128GO:0016887
GeneOntologyMolecularFunctioncaspase binding

FADD NLRC4

3.55e-03161122GO:0089720
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 ERCC6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

3.62e-032621126GO:0140097
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

5.36e-09131125GO:0015074
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

6.13e-06481125GO:0000731
GeneOntologyCellularComponentvoltage-gated potassium channel complex

HCN1 KCNB1 KCNG1 KCNG4 KCNAB3

1.25e-04911115GO:0008076
GeneOntologyCellularComponentpotassium channel complex

HCN1 KCNB1 KCNG1 KCNG4 KCNAB3

2.33e-041041115GO:0034705
GeneOntologyCellularComponentcation channel complex

AKAP6 HCN1 KCNB1 KCNG1 KCNG4 SCNN1D KCNAB3

2.62e-042351117GO:0034703
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNB1 KCNG1 KCNG4 KCNAB3

9.58e-0541834MM14546
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNB1 KCNG1 KCNG4 KCNAB3

1.16e-0443834M1056
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10

1.41e-074115310469592
Pubmed

Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.

KCNB1 KCNG1 KCNG4

3.50e-075115319074135
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-25 ERVK-11

7.36e-0794115621542922
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

HDAC5 C2CD5 PLEKHG3 MCM3AP MAST3 ADAMTSL2

1.41e-0610511569628581
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

ABCA2 MYO5B THSD7B DST MCM3AP MAST3

4.90e-06130115612421765
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MYH3 HCN1 TTC21A UBR4 PIDD1 DST ADAMTS9 KCNG1 KCNG4 GZMH MCM3AP DYNC1H1

6.23e-067361151229676528
Pubmed

Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.

KCNB1 KCNG4

1.08e-052115226505474
Pubmed

KCNG4 Genetic Variant Linked to Migraine Prevents Expression of KCNB1.

KCNB1 KCNG4

1.08e-052115239201645
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

1.08e-052115211687802
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

1.08e-052115234910522
Pubmed

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.

SIRT6 KDM2A

1.08e-052115232584788
Pubmed

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability.

ID3 MDC1

1.08e-052115229026069
Pubmed

Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci.

ID3 MDC1

1.08e-052115234877804
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-10 ERVK-25 ERVK-11

2.77e-0518115318664271
Pubmed

Functional proteomics mapping of a human signaling pathway.

ERCC6 SASH1 UBR4 DST MCM3AP PAPPA KDM2A KIF13A DYNC1H1 SMAD7

2.81e-055911151015231748
Pubmed

CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

CUL4A IPO5 IRS4 USP9X ASB13

3.08e-05108115530166453
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRC STRCP1

3.24e-053115230801007
Pubmed

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.

KCNB1 KCNG4

3.24e-053115226242757
Pubmed

Homozygosity for the C46T polymorphism of the F12 gene is a risk factor for venous thrombosis during the first pregnancy.

F5 F12

3.24e-053115217408404
Pubmed

LRDD, a novel leucine rich repeat and death domain containing protein.

FADD PIDD1

3.24e-053115210825539
Pubmed

Rapid triplex asymmetric real-time PCR hybridization probe assay for the joint genotyping of F2, F5 and F12.

F5 F12

3.24e-053115219422815
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-11

3.24e-05311529971820
Pubmed

A positive feedback loop between ID3 and PPARγ via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer.

ID3 MDC1

3.24e-053115237170184
Pubmed

HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation.

HDAC5 SMAD7

3.24e-053115236263180
Pubmed

Five prothrombotic polymorphisms and the prevalence of premature myocardial infarction.

F5 F12

3.24e-053115215749685
Pubmed

Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current.

KCNB1 KCNG1

3.24e-05311528980147
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MYO5B C2CD5 METTL13 TTBK1 ADAMTS9 PLEKHG3 KDM2A MAST3 ADAMTSL2

4.00e-05493115915368895
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

IRS4 USP9X F5 DST MCM3AP MARF1

5.16e-05197115620811636
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

CUL4A IPO5 USP9X ESYT1 LRRC49 UBR4 CSDE1 DYNC1H1

5.69e-05399115837536630
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IPO5 IRS4 USP9X UBR4 CSDE1 ACSL3 DST MCM3AP MDC1 DYNC1H1

6.47e-056531151022586326
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRC STRCP1

6.48e-054115218849963
Pubmed

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.

FADD PIDD1

6.48e-054115220935634
Pubmed

Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.

MYH2 MYH3

6.48e-054115220357587
Pubmed

A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death.

FADD NLRC4

6.48e-054115227974463
Pubmed

Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway.

HDAC5 SMAD7

6.48e-054115229886060
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-10

6.48e-05411527983737
Pubmed

Genome-scale study of transcription factor expression in the branching mouse lung.

ID3 TFAP2C FOXD4L3 FOXD4

7.40e-0567115422711520
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ATMIN ABCA2 ESYT1 UBR4 FBXL14 HIRA CCDC142 DST SH3TC1 KCNG1 MCM3AP DYNC1H1 SMAD7

7.66e-0511051151335748872
Pubmed

SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.

MYH3 WNT10B CIDEA

7.68e-0525115331433978
Pubmed

Major and potential prothrombotic genotypes in patients with venous thrombosis and in healthy subjects from Slovenia.

F5 F12

1.08e-045115219127083
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7

1.08e-045115212629516
Pubmed

The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.

F5 F12

1.08e-045115219415820
Pubmed

Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.

MYH2 MYH3

1.08e-04511526196357
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

1.08e-045115211401426
Pubmed

Id2, Id3 and Id4 overcome a Smad7-mediated block in tumorigenesis, generating TGF-β-independent melanoma.

ID3 SMAD7

1.08e-045115224343358
Pubmed

Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.

MYH2 MYH3

1.08e-04511523829126
Pubmed

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.

MYH2 MYH3

1.08e-04511526879174
Pubmed

EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice.

GZMH EBAG9

1.08e-045115235482418
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

STRC STRCP1

1.08e-045115224920589
Pubmed

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

FOXD4L3 FOXD4

1.61e-046115227092474
Pubmed

Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.

MYH2 MYH3

1.61e-046115210444070
Pubmed

Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.

MYH2 MYH3

1.61e-04611521728586
Pubmed

Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.

MYH2 MYH3

1.61e-046115210077619
Pubmed

Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.

CUL4A TRPC4AP

1.61e-046115220551172
Pubmed

The balance between acetylation and deacetylation controls Smad7 stability.

HDAC5 SMAD7

1.61e-046115215831498
Pubmed

PIDD mediates NF-kappaB activation in response to DNA damage.

FADD PIDD1

1.61e-046115216360037
Pubmed

Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases.

HDAC5 DST

1.61e-046115220887891
Pubmed

Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.

MYH2 MYH3

1.61e-046115210588881
Pubmed

Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin.

CUL4A ERCC6

1.61e-046115226826127
Pubmed

Role of thrombophilic gene polymorphisms in branch retinal vein occlusion.

F5 F12

1.61e-046115216157382
Pubmed

HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.

MYH2 MYH3 CIDEA

1.63e-0432115333732701
Pubmed

Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.

TRPC4AP F5 F12

1.79e-0433115322703881
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

ERCC6 WNT10B SIRT6 CSDE1 MDC1 PLD1 DYNC1H1

1.95e-04358115732460013
Pubmed

Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.

KCNB1 KCNG4

2.25e-047115212060745
Pubmed

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

MYH2 MYH3

2.25e-047115235210422
Pubmed

ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.

MYH2 MYH3

2.25e-047115229758057
Pubmed

Structural basis of human transcription-DNA repair coupling.

CUL4A ERCC6

2.25e-047115234526721
Pubmed

Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation.

CUL4A ERCC6

2.25e-047115229225035
Pubmed

Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.

MYH2 MYH3

2.25e-047115216819597
Pubmed

AP-2ε Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells.

TFAP2C SLC6A9

2.25e-047115229467543
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

CUL4A IRS4 USP9X LRRC49 C2CD5

2.55e-04169115531462741
Pubmed

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

CUL4A USP9X ID3 CSDE1 DST DYNC1H1

2.93e-04271115625737280
Pubmed

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.

HDAC5 TFAP2C

3.00e-048115224413532
Pubmed

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.

UBR4 KIF13A

3.00e-048115237871017
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

STRC STRCP1

3.00e-048115221165971
Pubmed

The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.

FOXD4L3 FOXD4

3.00e-04811528530406
Pubmed

A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.

CUL4A HIRA

3.00e-048115224209620
Pubmed

Cloning and expression analysis of murine phospholipase D1.

MYH2 PLD1

3.00e-04811529307024
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNB1 KCNG1 KCNG4

3.18e-0440115316382104
Pubmed

New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation.

IRS4 NELL1 PLD1

3.18e-0440115319864314
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

IPO5 IRS4 USP9X ESYT1 CSDE1

3.32e-04179115536261009
Pubmed

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.

CUL4A IPO5 UBR4 CSDE1 DYNC1H1

3.58e-04182115531067453
Pubmed

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

CUL4A ERCC6

3.84e-049115216751180
Pubmed

An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.

FOXD4L3 FOXD4

3.84e-049115212412011
Pubmed

Ataxin-3 promotes genome integrity by stabilizing Chk1.

CUL4A DYNC1H1

3.84e-049115228180282
Pubmed

Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.

CUL4A UBR4

3.84e-049115217855541
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CUL4A CDR2 TRPC4AP HDAC5 MYO5B ESYT1 TTC21A NXN ACSL3 MARF1 PAN3 DYNC1H1 MAST3

4.35e-0413211151327173435
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

IPO5 ATMIN USP9X WNT10B UBR4 SLC34A3 TFAP2C C2CD5 ACSL3 SLC6A9 TRMT44 MCM3AP KDM2A

4.54e-0413271151332694731
Pubmed

Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.

MYH2 MYH3

4.79e-041011528950513
Pubmed

Caspase-7 activates ASM to repair gasdermin and perforin pores.

NLRC4 GZMH

4.79e-0410115235705808
Pubmed

HiPLA: High-throughput imaging proximity ligation assay.

CUL4A SIRT6 MDC1

4.82e-0446115330419336
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

IRS4 SASH1 ESYT1 LRRC49 C2CD5 DST EBAG9

5.17e-04421115736976175
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

CUL4A USP9X KCNB1 MDC1 PLD1

5.38e-04199115536688959
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ERCC6 ESYT1 UBR4 HIRA CSDE1 ACSL3 METTL13 DST PLEKHG3 MCM3AP MDC1 KDM2A DYNC1H1

5.45e-0413531151329467282
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

HDAC5 ESYT1 UBR4 ID3 HIRA METTL13 SH3TC1 KDM2A DYNC1H1 FOXD4

5.69e-048571151025609649
Pubmed

USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription.

IRS4 USP9X

5.85e-0411115233558705
Pubmed

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

STRC STRCP1

5.85e-0411115231448880
Pubmed

Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

FOXD4L3 FOXD4

5.85e-0411115212421752
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

STRC STRCP1

5.85e-0411115231776257
Pubmed

Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.

MYH2 MYH3

5.85e-0411115216024798
Cytoband15q15.3

GOLM2 STRC STRCP1

3.38e-0525115315q15.3
GeneFamilyPotassium voltage-gated channels

KCNB1 KCNG1 KCNG4

5.60e-0440733274
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDR2 STAB2 SASH1 PLEKHA4 SLC6A9 ABCG4 SMIM1

1.39e-07160109756e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDR2 STAB2 SASH1 PLEKHA4 SLC6A9 ABCG4 SMIM1

1.39e-071601097bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 SASH1 FAM174B ID3 KCNB1 SH3TC1 SMAD7

4.77e-0719210972bfac6b3956265205ca47d06888851ed68b65999
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 SASH1 FAM174B ID3 KCNB1 SH3TC1 SMAD7

4.77e-071921097d525f7f088a53110912600a7c9f6d33b9270d534
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

AKAP6 DST KCNB1 MARF1 KIF13A DYNC1H1

4.93e-061771096e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellAT1_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

FAM174B NXN TMEM47 DST SEMA3B TACSTD2

5.43e-061801096e1964002681f80d8d62406b6ee52a01e1829ccf2
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GIPC2 MYO5B WNT10B FAM174B SEMA3B TACSTD2

5.78e-061821096573771130247e869e4e58f22d4a1cb31989635cf
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GIPC2 MYO5B WNT10B FAM174B SEMA3B TACSTD2

5.78e-0618210966cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AKAP6 VWA3A CERKL TTC21A LRRC49 RAB36

6.35e-0618510965e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO5B FAM174B NXN DST SEMA3B TACSTD2

7.40e-06190109630b50d183d7649146eb1e79b47ba897355f1998a
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GIPC2 MYO5B WNT10B FAM174B SEMA3B TACSTD2

7.85e-061921096790282d4232311df3dac4ad97c80fc53443beccc
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GIPC2 MYO5B WNT10B FAM174B SEMA3B TACSTD2

7.85e-061921096b2d9bffccd6264b4f12d88a0780646ee0b41969f
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

MYO5B FAM174B NXN DST SEMA3B TACSTD2

8.58e-06195109607a3ef6b0f1201fe2bcb9ea426b8f7a69beb4904
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

MYO5B FAM174B NXN DST SEMA3B TACSTD2

8.58e-061951096b65511770ed67f7447847e2187555b362988af45
ToppCellfacs-Heart-RA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SASH1 ID3 CSDE1 PAN3 ADAMTSL2 SMAD7

9.09e-061971096940cf1e54d7c820e04946258a8b784f35c6a144c
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 SLC6A9 TMEM47 ADAMTS9 SEMA3B PAPPA

9.36e-0619810965cfd1c030c0940136a397b5a4b5d6ecbaecf72eb
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 SLC6A9 TMEM47 ADAMTS9 SEMA3B PAPPA

9.36e-061981096ff6d9455ebfe965cc6f48197172c0ebd3bddde81
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 SLC6A9 TMEM47 ADAMTS9 SEMA3B PAPPA

9.36e-0619810965375a2895cf995f0db4a61861093f01794707901
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 SLC6A9 TMEM47 ADAMTS9 SEMA3B PAPPA

9.36e-06198109635edf6d5bedc2181fbdd56f43e458bc39f4eca16
ToppCellCOVID-19_Moderate-multiplets|COVID-19_Moderate / disease group, cell group and cell class

ABCA2 WNT10B TOGARAM2 SCART1 TACSTD2

3.09e-051471095baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A NPHS1 STAB2 KCNB1 KCNG4

3.30e-051491095cc6224c6b79f43b97adc1ce48ca4906bff2ad318
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-4|TCGA-Brain / Sample_Type by Project: Shred V9

HCN1 WNT10B CIDEA ABCG4 STRCP1

3.30e-051491095ff472ad641efd655905e99a9a4cacd5245ab8854
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A NPHS1 STAB2 KCNB1 KCNG4

3.30e-05149109524a7538b54b2a5291503c7493fefed4e45e8d710
ToppCellE17.5-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

AKAP6 GIPC2 PLEKHA4 ZDHHC23 SEMA3B

3.41e-051501095201d5b68e71c6c003285428be96c488e6d526edf
ToppCellLPS-antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWA3A MYO5B TFAP2C STRC ADAMTSL2

3.41e-0515010959cb3332924bd67c966873343c14445e30d3f384f
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLEKHA4 UST TRMT44 PAPPA KCNAB3

4.50e-0515910957ed659163f45e0c4df4782997c0786900c8186c8
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH2 MYH3 MYO5B THSD7B ZDHHC23

4.91e-0516210954d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

IRS4 F12 STRC TACSTD2

4.93e-0582109473349906bcc8d1a40dc03df7a490a963e85564f2
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

IRS4 F12 STRC TACSTD2

4.93e-0582109415bc417aaace2b1d680904a622fe76e95083c9ff
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

IRS4 F12 STRC TACSTD2

4.93e-05821094697e1da3095c8483b8181b290fa5417bdc9cee54
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A TOGARAM2 RAB36 GRID2IP KCNB1

5.21e-0516410959e16e52f5a634585f26021bcce9b5d5992ff6db0
ToppCellCiliated_cells-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

VWA3A CERKL MYH3 TTC21A TOGARAM2

5.52e-0516610954b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STAB2 ID3 RNF217 NXN ACSL3

5.68e-051671095f01b96173deda0239fa482989873cf308e49d48c
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOGARAM2 TFAP2C KCNG1 ALDH3B2 TACSTD2

5.68e-05167109502c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STAB2 ID3 RNF217 NXN ACSL3

5.68e-0516710955fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GIPC2 TTC21A TOGARAM2 CIDEA ZDHHC23

6.89e-051741095f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

FAM174B NXN ADAMTS9 SEMA3B TACSTD2

7.08e-051751095bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GIPC2 TTC21A TOGARAM2 CIDEA ZDHHC23

7.08e-051751095c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 MYO5B TOGARAM2 PAPPA KCNAB3

7.28e-051761095682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IRS4 SASH1 THSD7B TMEM47 AGXT

7.28e-051761095d09e28606e2a6ed1f660898316765ca215085c18
ToppCellB_cells-Naive_B_cells_|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

ATP10D CLCN4 P2RX5 KCNG1 KCNAB3

7.68e-05178109571ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCellfacs-Brain_Myeloid-Cortex-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM174B ID3 F12 TMEM47 KCNB1

7.88e-0517910950cef6d2eab2015cac0dd340532b24bfec9707330
ToppCellremission-B_naive|World / disease stage, cell group and cell class

AKAP6 TTC21A ID3 P2RX5 KCNG1

8.52e-051821095cc1dfd2de35aee1a26f7efd78e108b60a3556ec5
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TOGARAM2 ASB13 PAPPA KCNAB3

8.75e-05183109504d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO5B TOGARAM2 THSD7B ADAMTS9 KCNAB3

8.75e-0518310955a541a7f6c3514be8a13e988185dfe388c874f8b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IRS4 SASH1 THSD7B TMEM47 PAPPA

8.75e-051831095439b1d1373b7cc73d65f3b59037a6def7cf8f4ba
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CERKL MYO5B FAM174B ATP10D SLC6A9

8.75e-051831095919c9861073d12fd12aecd7469b1478b13838c43
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A NPHS1 NXN F5 PLEKHG3

9.93e-051881095b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A NPHS1 NXN F5 PLEKHG3

9.93e-051881095874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

VWA3A CERKL TTC21A TOGARAM2 RAB36

1.02e-041891095a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 MYO5B TOGARAM2 PAPPA KCNAB3

1.04e-0419010953f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GIPC2 MYO5B FAM174B SEMA3B TACSTD2

1.07e-041911095ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GIPC2 MYO5B FAM174B SEMA3B TACSTD2

1.07e-041911095c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AKAP6 VWA3A CERKL TTC21A PLEKHA4

1.12e-041931095ea345d34440b25f65358a53dc72831998d1c3620
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 MYO5B TMEM47 PAPPA KCNAB3

1.12e-0419310955581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 FAM174B KCNB1 SH3TC1 SMAD7

1.15e-041941095c8b9551b93a5aed62154b487db90130604a6125c
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

VWA3A CERKL LRRC49 TOGARAM2 RAB36

1.15e-0419410951ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 VWA3A TTC21A TOGARAM2 MUC16

1.15e-0419410954a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC16 THSD7B F5 TTBK1 KCNB1

1.18e-041951095d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5B FAM174B NXN DST SEMA3B

1.18e-041951095a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VWA3A MYO5B MUC16 RAB36 AGXT

1.18e-041951095e525b69145059b66417589601f7109af63730f3a
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC16 THSD7B F5 TTBK1 KCNB1

1.18e-04195109519853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GIPC2 ID3 TMEM47 DST SMAD7

1.21e-041961095cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCell(7)_Epithelial-I_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

MYO5B FAM174B DST SEMA3B TACSTD2

1.21e-041961095150554fa06868d29b0608189862eef6505ba757f
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 VWA3A TTC21A TOGARAM2 KCNB1

1.24e-04197109574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellAT1_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

FAM174B NXN DST SEMA3B TACSTD2

1.24e-04197109580d81be244c94c435accb643449b4ce6a3462c7f
ToppCellASK440-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

FAM174B ID3 DST SEMA3B TACSTD2

1.24e-041971095782449c522c9e16e72bf999a73090688a3aefe06
ToppCellPBMC-Mild-cDC_0|Mild / Compartment, Disease Groups and Clusters

SASH1 F5 PLD1 KIF13A SMAD7

1.27e-041981095fb873b7636bb1c7b119dd5b23d7a20f518e6c6da
ToppCellASK428-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

FAM174B DST SEMA3B TACSTD2 SMAD7

1.27e-0419810950047a9ef7684230ac5179efea94461480e90bdaf
ToppCellfacs-Brain_Non-Myeloid-Hippocampus|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC4AP SASH1 CSDE1 ACSL3 KIF13A

1.33e-042001095fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-GXYLT2|Neuronal / cells hierarchy compared to all cells using T-Statistic

IRS4 SASH1 THSD7B TMEM47 PAPPA

1.33e-04200109537728d83b246dd70933d1f52f938bc1c401df7b9
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-GXYLT2--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

IRS4 SASH1 THSD7B TMEM47 PAPPA

1.33e-042001095cafa1b46d0b052fca6191ad99d5862a07d0a1fd2
ToppCellSepsis-Bac-SEP-Lymphocyte-B-B_naive|Bac-SEP / Disease, condition lineage and cell class

TTC21A ID3 CLCN4 P2RX5 KCNG1

1.33e-042001095d377227314a4684d1bad15a13d87b1fa74b998f1
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-GXYLT2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

IRS4 SASH1 THSD7B TMEM47 PAPPA

1.33e-042001095fe63aa1febd2bf650a7dd4e8b4420063580644ba
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

SASH1 MYO5B THSD7B PAPPA KCNAB3

1.33e-042001095107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)|Neuronal / cells hierarchy compared to all cells using T-Statistic

IPO5 VWA3A CERKL KIF13A MAST3

1.33e-0420010950f23e72649a274043bf23e0952a9b5707c516acf
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC4AP SASH1 CSDE1 ACSL3 KIF13A

1.33e-042001095f0c338877e39226a90c4effe12f6501d33542a73
ToppCellSubstantia_nigra|World / BrainAtlas - Mouse McCarroll V32

CDR2 IRS4 SLC6A9 PAPPA

1.83e-04115109418174b8d57d444fab1e9d2b13d22939c83c958e0
DiseaseColorectal Carcinoma

AKAP6 IRS4 ERCC6 AMDHD2 SETD4 NXN F5 NELL1 SH3TC1 MCM3AP KDM2A SMAD7

7.76e-0670210512C0009402
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

1.25e-0521052DOID:0110471 (implicated_via_orthology)
Diseasehepcidin:transferrin saturation ratio

MUC16 NELL1 PAN3

1.93e-05151053EFO_0007902
DiseaseArthrogryposis

MYH3 ERCC6 DYNC1H1

5.56e-05211053C0003886
DiseaseSjogren-Larsson syndrome (implicated_via_orthology)

ACSL3 ALDH3B2

1.86e-0461052DOID:14501 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:0110454 (implicated_via_orthology)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:0111269 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:0080719 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:0111602 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:0080326 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH2 MYH3

5.54e-04101052DOID:0111596 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH2 MYH3

8.09e-04121052DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH2 MYH3

8.09e-04121052DOID:2106 (implicated_via_orthology)
DiseaseThromboembolism

F5 F12

8.09e-04121052C0040038
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH2 MYH3

9.54e-04131052DOID:397 (implicated_via_orthology)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH2 MYH3

1.28e-03151052DOID:0050646 (implicated_via_orthology)
DiseaseInborn Errors of Metabolism

MYO5B ADAMTSL2

1.65e-03171052C0025521
DiseaseParoxysmal atrial fibrillation

AKAP6 CUL4A UST SMAD7

2.38e-031561054C0235480
Diseasefamilial atrial fibrillation

AKAP6 CUL4A UST SMAD7

2.38e-031561054C3468561
DiseasePersistent atrial fibrillation

AKAP6 CUL4A UST SMAD7

2.38e-031561054C2585653
Diseasestem Cell Growth Factor beta measurement

STAB2 F5 F12

2.45e-03751053EFO_0008292
DiseaseAtrial Fibrillation

AKAP6 CUL4A UST SMAD7

2.60e-031601054C0004238
Diseasepartial thromboplastin time

F5 F12

3.29e-03241052EFO_0004310

Protein segments in the cluster

PeptideGeneStartEntry
LGRCKVRLTTVLNSG

ESYT1

731

Q9BSJ8
TRTALLSGGQRKRLA

ABCG4

196

Q9H172
CLNASLLGGVLRRAK

TFAP2C

256

Q92754
CRVNLRKATGVRGLE

ASB13

246

Q8WXK3
IACLLLRVFRSGKRL

FAM174B

106

Q3ZCQ3
LQEKSRKRCGGILVR

GZMH

41

P20718
CVRLLGRNSNSKRLL

CSDE1

506

O75534
EKIGCGRATLRLRSK

GIPC2

216

Q8TF65
LRLLTGERGCQVASR

CCDC142

236

Q17RM4
IFRKLGLRQCLVTRS

CLCN4

716

P51793
GLRQCLVTRSGRLLG

CLCN4

721

P51793
QRLRALLGCSRVAIG

ALDH3B2

211

P48448
ALRLSRQRCLGAVSG

ERCC6

1296

Q03468
RVGLSKENLLLRGCT

ATP10D

266

Q9P241
FLKRLICRSGRGRKL

EBAG9

21

O00559
ICRSGRGRKLSGDQI

EBAG9

26

O00559
CQRRNTGTVGLKLSK

RAB36

111

O95755
LRRVAGSVLKACGLL

SLC34A3

66

Q8N130
ICGVLVTTRRRKKEG

MUC16

14471

Q8WXI7
EGQKLRAGTRVRLVC

NPHS1

451

O60500
NIQGITKCTIRRLAR

H4C7

26

Q99525
IRRTVKFLCALGRGI

MDC1

1931

Q14676
RLQIKRCAGVAGSLS

NLRC4

691

Q9NPP4
GRITLKCGRNISILR

DST

1746

Q03001
CKGSGERVQGLRRIC

FOXD4L3

331

Q6VB84
GISCTRLRRLRNKTA

MCM3AP

1306

O60318
GLQTLGLTVRRCTRE

KCNG4

356

Q8TDN1
KLAQLITRTQARCRG

MYH2

786

Q9UKX2
TLIGQTRLRIIKLCG

HERVK_113

381

P63132
GLSTLRCLRVLLLGK

LRRC49

151

Q8IUZ0
CNTTCGRGVKKRLVL

ADAMTSL2

806

Q86TH1
LGLQTLGLTARRCTR

KCNG1

361

Q9UIX4
LRKVLGRCGSSQSIR

OR2T35

301

Q8NGX2
RRRLILANCDISKIG

PAPPA

406

Q13219
RLLRGKTIECISLIG

IPO5

551

O00410
CTRITKRGLERITQL

FBXL14

366

Q8N1E6
SCKGSGERVQGLRRV

FOXD4

326

Q12950
TLIGQTRLRIIKLCG

ERVK-7

381

P63135
TLIGQTRLRIIKLCG

ERVK-6

381

Q9BXR3
QRILTKSCRECRGGV

NELL1

346

Q92832
ILITGKTRLRVNCVG

PAN3

646

Q58A45
ILRRAGCVRALAKIE

FUOM

101

A2VDF0
KLCGGGIRTRLVVCQ

ADAMTS9

1396

Q9P2N4
RTNILCTVRGCGKIL

ATMIN

81

O43313
ICLLTKGRRTASVRA

HCN1

541

O60741
SQGLLGKLCRARRAQ

GRID2IP

211

A4D2P6
RRIANVTLIDLRGCK

KDM2A

1116

Q9Y2K7
SKACSRRVRLNVGGL

KCNB1

26

Q14721
CIRRAKAVKQRGISL

CDR2

331

Q01850
RTLQSLACGKARVLI

CUL4A

626

Q13619
LCLGRVGKRKLERVQ

FADD

26

Q13158
SRKIGRILAVDRLCL

ABCA2

2061

Q9BZC7
RCSVKQQRSGTLLGI

CERKL

106

Q49MI3
RLRRLSDNCGGKVLS

MARF1

531

Q9Y4F3
RGRGCRSGNRKSLVV

MAST3

21

O60307
LRTVLRRSGCKNEKI

DYNC1H1

2976

Q14204
ICIERCLERGKSSGR

CMPK1

126

P30085
GCTTVIERGTLRRLK

LINC01545

31

Q5VT33
CLSERSLAIARGRGK

ID3

16

Q02535
TGLLSKCERIRGRKA

HDAC5

721

Q9UQL6
TVVGGVKLSRLKCNR

HIRA

711

P54198
CSQLRRKARLGSVSL

METTL13

256

Q8N6R0
AIRLVCSRGNRLKTT

SCNN1D

236

P51172
TVIGKGCLIQARLCR

C2CD5

506

Q86YS7
GKLTRIVVLNLCGNR

LRRC30

91

A6NM36
CLRSLVLKGGQRRDT

PIDD1

91

Q9HB75
VTAGNGVKTGRCLRR

P2RX5

141

Q93086
GVKTGRCLRRENLAR

P2RX5

146

Q93086
RLILESKRRRCGTLG

IRS4

196

O14654
RNLGKSGLRVSCLGL

KCNAB3

81

O43448
IGCVTARSTKLQRGL

KIF13A

1056

Q9H1H9
LTRNGPLSCGQRLRK

F12

351

P00748
LSSRLQAREGLGKRC

GOLM2

91

Q6P4E1
TIGSVRRCILNRIKA

USP9X

911

Q93008
GKVLRIGLLGCNATR

AGXT

356

P21549
TETLRRLKRECGGLQ

TRMT44

656

Q8IYL2
RLKRECGGLQTLLRN

TRMT44

661

Q8IYL2
LVCDGKRGLLTRLLQ

TRPC4AP

506

Q8TEL6
SGNIRGVVCRLSRSL

TOGARAM2

946

Q6ZUX3
GLLLICKSRSLDRRG

F5

521

P12259
TTGKVVCRNGLLVIR

NXN

141

Q6DKJ4
GIRIDNLSRTLILKC

PLD1

296

Q13393
LSGRVGRCRSLSTKR

PLEKHG3

1091

A1L390
TLLTKLCGQDRLLRR

PLEKHA4

366

Q9H4M7
VGVRRTDKGDLSLRC

TACSTD2

131

P09758
RRSVARLLLQAGKAG

MRM1

66

Q6IN84
IRRRKLCGSSESRGV

SETD4

11

Q9NVD3
RVKTRRGQLGLASSC

SMCR5

6

Q8TEV8
LGRLCSRRLKLSQAR

SH3TC1

566

Q8TE82
RLAKLITRTQAVCRG

MYH3

781

P11055
RRLVRGSVCAGKLFI

RNF217

486

Q8TC41
RRISQRLCTGKLGIA

SMIM1

36

B2RUZ4
ATGRLCTVAKARGLR

SIRT6

161

Q8N6T7
SALSGSNRRLVKRLC

STRC

431

Q7RTU9
KQRRRGVASILRLCQ

AKAP6

1131

Q13023
KVRSLLGGNIRLLLC

ACSL3

436

O95573
IRCTGLKGLLRSLLR

CIDEA

161

O60543
TLIGQTRLRIIKLCG

ERVK-25

381

P63136
GKCGSRTVVLLLRIL

UST

111

Q9Y2C2
QKVRSKIGCGIQLTR

SMAD7

311

O15105
KRQGRLLLRLASGAS

TTBK1

1096

Q5TCY1
ALGRLSVSRVGQICR

SEMA3B

256

Q13214
TLIGQTRLRITKLCG

ERVK-10

381

P10266
TLIGQTRLRIIKLCG

ERVK-8

381

P63133
TLIGQTRLRIIKLCG

ERVK-11

381

Q9UQG0
RLCRTDGDTLLQRLK

SLC6A9

631

P48067
GLNKNRRSLPVSICR

SASH1

806

O94885
GQARRCDRKSLLTIR

STAB2

26

Q8WWQ8
RGSVQVALSRVRCLG

SCART1

491

Q4G0T1
FLVGLISICVGSRRR

TMEM47

96

Q9BQJ4
LRLLQGLCRLATREK

TTC21A

1126

Q8NDW8
QKTGRRLLCGLIVDT

ZDHHC23

391

Q8IYP9
PQSGCTRKLRNRAAL

ZFP42

191

Q96MM3
SALSGSNRRLVKRLC

STRCP1

431

A6NGW2
LSGLSKRQLGLCLRN

WNT10B

51

O00744
LRSLRCGGGTQSRKI

THSD7B

1076

Q9C0I4
VRRQVRKLLLFICGS

UBR4

3206

Q5T4S7
LRCRGSRNVLSALRK

VWA3A

581

A6NCI4
RLKGATLTLQRYCRG

MYO5B

786

Q9ULV0
RVLQFTNCRILRGGK

AMDHD2

11

Q9Y303