Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontestosterone 6-beta-hydroxylase activity

CYP3A7 CYP3A4 CYP3A43

7.14e-075843GO:0050649
GeneOntologyMolecularFunctionestrogen 2-hydroxylase activity

CYP3A7 CYP3A4 CYP3A43

3.96e-068843GO:0101021
GeneOntologyMolecularFunctionestrogen 16-alpha-hydroxylase activity

CYP3A7 CYP3A4 CYP3A43

1.16e-0511843GO:0101020
GeneOntologyMolecularFunctionMAP-kinase scaffold activity

AKAP13 MAP2K1 MAP2K2

1.99e-0513843GO:0005078
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP3A7 CYP3A4 CYP3A43

2.53e-0514843GO:0008401
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

TRIO DOCK11 MCF2L2 AKAP13 MCF2L RAPGEFL1 PLCE1

5.38e-05231847GO:0005085
GeneOntologyMolecularFunctionsmall GTPase binding

ANKFY1 DOCK11 HACE1 AKAP13 MAP2K1 USP33 XPOT PLCE1

6.17e-05321848GO:0031267
GeneOntologyMolecularFunctiontestosterone 16-alpha-hydroxylase activity

CYP3A4 CYP3A43

1.04e-044842GO:0008390
GeneOntologyMolecularFunctionGTPase binding

ANKFY1 DOCK11 HACE1 AKAP13 MAP2K1 USP33 XPOT PLCE1

1.37e-04360848GO:0051020
GeneOntologyMolecularFunctionvitamin D 23-hydroxylase activity

CYP3A4 CYP3A43

1.73e-045842GO:0062179
GeneOntologyMolecularFunction1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity

CYP3A4 CYP3A43

1.73e-045842GO:0062181
GeneOntologyMolecularFunctionvitamin D 24-hydroxylase activity

CYP3A4 CYP3A43

2.59e-046842GO:0070576
GeneOntologyMolecularFunctionvitamin D3 25-hydroxylase activity

CYP3A4 CYP3A43

2.59e-046842GO:0030343
GeneOntologyMolecularFunctionvitamin D 25-hydroxylase activity

CYP3A4 CYP3A43

3.62e-047842GO:0070643
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP3A7 CYP3A4 CYP3A43

3.91e-0434843GO:0008395
GeneOntologyMolecularFunctionaromatase activity

CYP3A7 CYP3A4 CYP3A43

4.26e-0435843GO:0070330
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

CYP3A4 CYP3A43

4.82e-048842GO:0033695
GeneOntologyMolecularFunctioncaffeine oxidase activity

CYP3A4 CYP3A43

4.82e-048842GO:0034875
GeneOntologyMolecularFunctionoxygen binding

CYP3A7 CYP3A4 ALB

5.03e-0437843GO:0019825
GeneOntologyMolecularFunctioncysteine-type endopeptidase inhibitor activity

CST1 CST2 CST4

7.85e-0443843GO:0004869
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP3A7 CYP3A4 CYP3A43

1.15e-0349843GO:0016712
GeneOntologyMolecularFunctionproteoglycan binding

PTPRF PTPRS SLIT1

1.29e-0351843GO:0043394
GeneOntologyMolecularFunctionphosphatidate phosphatase activity

LPIN1 LPIN2

1.54e-0314842GO:0008195
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP3A4 CYP3A43

1.77e-0315842GO:0016725
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine phosphatase activity

PTPRD PTPRF

2.28e-0317842GO:0005001
GeneOntologyMolecularFunctiontransmembrane receptor protein phosphatase activity

PTPRD PTPRF

2.28e-0317842GO:0019198
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DYNC1H1 DNAH14

2.56e-0318842GO:0008569
GeneOntologyMolecularFunctionMAP kinase kinase activity

MAP2K1 MAP2K2

2.56e-0318842GO:0004708
GeneOntologyMolecularFunctionRNA polymerase binding

AGO1 TCERG1L PHRF1

2.60e-0365843GO:0070063
GeneOntologyMolecularFunctionlipid phosphatase activity

LPIN1 LPIN2

2.85e-0319842GO:0042577
GeneOntologyMolecularFunctiondouble-stranded RNA binding

AGO1 DDX60 OAS2

4.35e-0378843GO:0003725
GeneOntologyBiologicalProcessnegative regulation of collagen catabolic process

CST1 CST2 CST4

6.25e-075833GO:0010711
GeneOntologyBiologicalProcessnegative regulation of elastin catabolic process

CST1 CST2 CST4

6.25e-075833GO:0060311
GeneOntologyBiologicalProcessregulation of elastin catabolic process

CST1 CST2 CST4

1.25e-066833GO:0060310
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine phosphatase signaling pathway

PTPRD PTPRF TRIO

2.17e-067833GO:0007185
GeneOntologyBiologicalProcessnegative regulation of blood vessel remodeling

CST1 CST2 CST4

2.17e-067833GO:0060313
GeneOntologyBiologicalProcessgrowth plate cartilage chondrocyte growth

CST1 CST2 CST4

2.17e-067833GO:0003430
GeneOntologyBiologicalProcessregulation of collagen catabolic process

CST1 CST2 CST4

5.19e-069833GO:0010710
GeneOntologyBiologicalProcesslipid hydroxylation

CYP3A7 CYP3A4 CYP3A43

5.19e-069833GO:0002933
GeneOntologyBiologicalProcessnegative regulation of extracellular matrix disassembly

CST1 CST2 CST4

7.39e-0610833GO:0010716
GeneOntologyBiologicalProcesselastin catabolic process

CST1 CST2 CST4

7.39e-0610833GO:0060309
GeneOntologyBiologicalProcessgrowth plate cartilage chondrocyte development

CST1 CST2 CST4

7.39e-0610833GO:0003431
GeneOntologyBiologicalProcesschondrocyte hypertrophy

CST1 CST2 CST4

7.39e-0610833GO:0003415
GeneOntologyBiologicalProcessoxidative demethylation

CYP3A7 CYP3A4 CYP3A43

1.35e-0512833GO:0070989
GeneOntologyBiologicalProcesschondrocyte development involved in endochondral bone morphogenesis

CST1 CST2 CST4

1.75e-0513833GO:0003433
GeneOntologyBiologicalProcessregulation of axon regeneration

PTPRF PTPRS MAP2K1 MAP2K2

1.99e-0540834GO:0048679
GeneOntologyBiologicalProcesselastin metabolic process

CST1 CST2 CST4

2.22e-0514833GO:0051541
GeneOntologyBiologicalProcessgrowth plate cartilage chondrocyte differentiation

CST1 CST2 CST4

2.22e-0514833GO:0003418
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

PTPRD PTPRF DOCK11 PRKCQ CORO1B DMD IKBKB MAP2K1 MAP2K2 PLCE1

2.88e-054948310GO:0031346
GeneOntologyBiologicalProcessregulation of neuron projection regeneration

PTPRF PTPRS MAP2K1 MAP2K2

3.81e-0547834GO:0070570
GeneOntologyBiologicalProcesschondrocyte differentiation involved in endochondral bone morphogenesis

CST1 CST2 CST4

6.82e-0520833GO:0003413
GeneOntologyBiologicalProcesspositive regulation of DNA replication

LPIN1 CST1 CST2 CST4

8.77e-0558834GO:0045740
GeneOntologyBiologicalProcessregulation of Golgi inheritance

MAP2K1 MAP2K2

9.55e-054832GO:0090170
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

PTPRD PTPRF TRIO PTPRS SLIT1 CC2D1A PRKCQ CORO1B DMD MAP2K1 MAP2K2 USP33

1.03e-048198312GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

PTPRD PTPRF TRIO PTPRS SLIT1 CC2D1A PRKCQ CORO1B DMD MAP2K1 MAP2K2 USP33

1.11e-048268312GO:0048858
GeneOntologyBiologicalProcessdemethylation

CYP3A7 CYP3A4 CYP3A43

1.20e-0424833GO:0070988
GeneOntologyBiologicalProcessregulation of extracellular matrix disassembly

CST1 CST2 CST4

1.36e-0425833GO:0010715
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

PTPRD PTPRF DOCK11 PTPRS SLIT1 PRKCQ CORO1B DMD IKBKB MAP2K1 MAP2K2 PLCE1

1.39e-048468312GO:0120035
GeneOntologyBiologicalProcessnegative regulation of extracellular matrix organization

CST1 CST2 CST4

1.53e-0426833GO:1903054
GeneOntologyBiologicalProcessalkaloid catabolic process

CYP3A4 CYP3A43

1.59e-045832GO:0009822
GeneOntologyBiologicalProcessregulation of cell projection organization

PTPRD PTPRF DOCK11 PTPRS SLIT1 PRKCQ CORO1B DMD IKBKB MAP2K1 MAP2K2 PLCE1

1.68e-048638312GO:0031344
GeneOntologyBiologicalProcessaxon regeneration

PTPRF PTPRS MAP2K1 MAP2K2

1.73e-0469834GO:0031103
GeneOntologyBiologicalProcessnegative regulation of collagen metabolic process

CST1 CST2 CST4

1.91e-0428833GO:0010713
GeneOntologyBiologicalProcessgrowth plate cartilage development

CST1 CST2 CST4

2.13e-0429833GO:0003417
GeneOntologyBiologicalProcessregulation of blood vessel remodeling

CST1 CST2 CST4

2.86e-0432833GO:0060312
GeneOntologyBiologicalProcessnegative regulation of glycoprotein metabolic process

CST1 CST2 CST4

3.14e-0433833GO:1903019
GeneOntologyBiologicalProcessneuron projection regeneration

PTPRF PTPRS MAP2K1 MAP2K2

3.20e-0481834GO:0031102
GeneOntologyBiologicalProcesstrachea formation

MAP2K1 MAP2K2

3.32e-047832GO:0060440
GeneOntologyBiologicalProcessneuron projection morphogenesis

PTPRD PTPRF TRIO PTPRS SLIT1 CC2D1A PRKCQ DMD MAP2K1 MAP2K2 USP33

3.60e-048028311GO:0048812
GeneOntologyBiologicalProcessendochondral bone growth

CST1 CST2 CST4

5.17e-0439833GO:0003416
GeneOntologyBiologicalProcessregeneration

LPIN1 PTPRF PTPRS DMD MAP2K1 MAP2K2

5.39e-04252836GO:0031099
GeneOntologyBiologicalProcessretinoic acid metabolic process

CYP3A7 CYP3A4 CYP3A43

5.58e-0440833GO:0042573
GeneOntologyBiologicalProcessalkaloid metabolic process

CYP3A4 CYP3A43

5.65e-049832GO:0009820
GeneOntologyBiologicalProcesschondrocyte development

CST1 CST2 CST4

6.00e-0441833GO:0002063
GeneOntologyBiologicalProcessglycoprotein catabolic process

CST1 CST2 CST4

6.00e-0441833GO:0006516
GeneOntologyBiologicalProcesssynaptic membrane adhesion

PTPRD PTPRF PTPRS

6.44e-0442833GO:0099560
GeneOntologyBiologicalProcessreplacement ossification

CST1 CST2 CST4

6.90e-0443833GO:0036075
GeneOntologyBiologicalProcessendochondral ossification

CST1 CST2 CST4

6.90e-0443833GO:0001958
GeneOntologyBiologicalProcessnucleus localization

SLIT1 DMD DYNC1H1

7.39e-0444833GO:0051647
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of bitter taste

CST1 CST2 CST4

7.39e-0444833GO:0001580
GeneOntologyBiologicalProcessbone growth

CST1 CST2 CST4

7.89e-0445833GO:0098868
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

PTPRD PTPRF TRIO PTPRS SLIT1 CC2D1A PRKCQ MAP2K1 MAP2K2 USP33

8.26e-047488310GO:0048667
GeneOntologyBiologicalProcessresponse to axon injury

PTPRF PTPRS MAP2K1 MAP2K2

8.56e-04105834GO:0048678
GeneOntologyBiologicalProcesscartilage development involved in endochondral bone morphogenesis

CST1 CST2 CST4

8.97e-0447833GO:0060351
GeneOntologyBiologicalProcessnegative regulation of tissue remodeling

CST1 CST2 CST4

8.97e-0447833GO:0034104
GeneOntologyBiologicalProcesssensory perception of bitter taste

CST1 CST2 CST4

9.54e-0448833GO:0050913
GeneOntologyBiologicalProcessepithelial cell proliferation involved in lung morphogenesis

MAP2K1 MAP2K2

1.03e-0312832GO:0060502
GeneOntologyBiologicalProcesstrachea morphogenesis

MAP2K1 MAP2K2

1.03e-0312832GO:0060439
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

SETDB2 THBS2 ANKFY1 PTPRD PTPRF DOCK11 PRKCQ CORO1B DMD IKBKB MAP2K1 MAP2K2 DYNC1H1 PLCE1

1.04e-0313668314GO:0051130
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of taste

CST1 CST2 CST4

1.07e-0350833GO:0050912
GeneOntologyBiologicalProcessestrogen metabolic process

CYP3A7 CYP3A4 CYP3A43

1.20e-0352833GO:0008210
GeneOntologyBiologicalProcessERBB2-ERBB3 signaling pathway

MAP2K1 MAP2K2

1.21e-0313832GO:0038133
GeneOntologyBiologicalProcesscollagen catabolic process

CST1 CST2 CST4

1.27e-0353833GO:0030574
GeneOntologyBiologicalProcessregulation of synapse assembly

THBS2 PTPRD PTPRS SLIT1 CC2D1A

1.34e-03202835GO:0051963
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

THBS2 AGO1 PTPRD PTPRF PTPRS SLIT1 CST1 CST2 CST4 CORO1B MAP2K1 MAP2K2

1.34e-0310908312GO:0022603
GeneOntologyBiologicalProcessdevelopmental cell growth

PTPRS SLIT1 CST1 CST2 CST4 AKAP13

1.35e-03301836GO:0048588
GeneOntologyBiologicalProcessERBB3 signaling pathway

MAP2K1 MAP2K2

1.41e-0314832GO:0038129
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

TRIO DOCK11 HACE1 AKAP13 MCF2L MAP2K1 RAPGEFL1 PLCE1

1.44e-03538838GO:0007264
GeneOntologyBiologicalProcessregulation of cell junction assembly

THBS2 PTPRD PTPRS SLIT1 CC2D1A IKBKB

1.55e-03309836GO:1901888
GeneOntologyBiologicalProcesspostsynaptic density organization

RAPSN PTPRD PTPRS

1.65e-0358833GO:0097106
GeneOntologyCellularComponentbasement membrane

THBS2 CST1 CST2 CST4 ALB

1.41e-04122855GO:0005604
GeneOntologyCellularComponentsupramolecular fiber

MYH13 EFCAB6 CST1 CST2 TPX2 CST4 AKAP13 KLHL41 CORO1B DMD MAP2K1 MAP2K2 DYNC1H1 DNAH14

2.70e-0411798514GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

MYH13 EFCAB6 CST1 CST2 TPX2 CST4 AKAP13 KLHL41 CORO1B DMD MAP2K1 MAP2K2 DYNC1H1 DNAH14

2.90e-0411878514GO:0099081
GeneOntologyCellularComponentneuronal cell body

PTPRF KCNC1 PTPRS CST1 CST2 TPX2 CST4 DMD MAP2K1 DYNC1H1 USP33

5.56e-048358511GO:0043025
GeneOntologyCellularComponentgranular component

RRP1B CDKN2AIP

5.77e-049852GO:0001652
GeneOntologyCellularComponentaxon

AGBL4 PTPRF KCNC1 PTPRS CST1 CST2 TPX2 CST4 DMD MAP2K1 DYNC1H1

9.49e-048918511GO:0030424
GeneOntologyCellularComponentcontractile muscle fiber

MYH13 CST1 CST2 CST4 KLHL41 DMD

1.18e-03290856GO:0043292
GeneOntologyCellularComponentcell body

PTPRF KCNC1 PTPRS CST1 CST2 TPX2 CST4 DMD MAP2K1 DYNC1H1 USP33

1.33e-039298511GO:0044297
GeneOntologyCellularComponentperinuclear region of cytoplasm

GBP7 CST1 CST2 CST4 OAS2 AKAP13 CORO1B DMD MAP2K1 MAP2K2 USP33

1.39e-039348511GO:0048471
MousePhenoabnormal long bone epiphysis morphology

CST1 CST2 CST4 HELLS

1.28e-0530684MP:0000131
MousePhenoloss of hippocampal neurons

CST1 CST2 CST4

2.35e-0512683MP:0003240
MousePhenoincreased metastatic potential

CST1 CST2 TPX2 CST4

3.34e-0538684MP:0001272
MousePhenodecreased susceptibility to ischemic brain injury

CST1 CST2 CST4 F12

9.20e-0549684MP:0006059
MousePhenodecreased response to brain injury

CST1 CST2 CST4 F12

9.20e-0549684MP:0014522
MousePhenosmall superior vagus ganglion

CST1 CST2 CST4

1.18e-0420683MP:0001102
MousePhenoabnormal superior vagus ganglion morphology

CST1 CST2 CST4

1.82e-0423683MP:0001101
MousePhenodecreased trabecular bone volume

GNPTAB CST1 CST2 CST4

2.03e-0460684MP:0010879
MousePhenoabnormal metastatic potential

CST1 CST2 TPX2 CST4

2.61e-0464684MP:0000858
MousePhenoabnormal interleukin-6 secretion

CLEC4E TRAFD1 GNPTAB CC2D1A DMD IKBKB

2.83e-04186686MP:0008704
DomainCyt_P450_E_grp-II

CYP3A7 CYP3A4 CYP3A43

8.72e-075843IPR002402
DomainCyt_P450_E_CYP3A

CYP3A7 CYP3A4 CYP3A43

1.74e-066843IPR008072
DomainProt_inh_cystat_CS

CST1 CST2 CST4

7.23e-069843IPR018073
DomainSpectrin/alpha-actinin

TRIO MCF2L2 DMD MCF2L

1.24e-0532844IPR018159
DomainSPEC

TRIO MCF2L2 DMD MCF2L

1.24e-0532844SM00150
DomainCystatin

CST1 CST2 CST4

1.88e-0512843IPR027214
DomainCYSTATIN

CST1 CST2 CST4

1.88e-0512843PS00287
DomainCY

CST1 CST2 CST4

5.70e-0517843SM00043
DomainLipin_N

LPIN1 LPIN2

5.98e-053842IPR007651
DomainLipin_mid

LPIN1 LPIN2

5.98e-053842PF16876
DomainLipin_mid

LPIN1 LPIN2

5.98e-053842IPR031703
DomainLipin_N

LPIN1 LPIN2

5.98e-053842PF04571
Domain-

GTF2H1 TRIO DOCK11 MCF2L2 AKAP13 MCF2L MTMR10 MPRIP PLCE1

6.49e-053918492.30.29.30
DomainCystatin_dom

CST1 CST2 CST4

6.82e-0518843IPR000010
DomainCystatin

CST1 CST2 CST4

6.82e-0518843PF00031
DomainPH_dom-like

GTF2H1 TRIO DOCK11 MCF2L2 AKAP13 MCF2L MTMR10 MPRIP PLCE1

1.25e-04426849IPR011993
DomainSpectrin

TRIO DMD MCF2L

1.46e-0423843PF00435
DomainDH_1

TRIO MCF2L2 AKAP13 MCF2L

1.85e-0463844PS00741
DomainSEC14

TRIO MCF2L2 MCF2L

1.88e-0425843SM00516
DomainCRAL_TRIO

TRIO MCF2L2 MCF2L

2.37e-0427843PS50191
DomainRhoGEF

TRIO MCF2L2 AKAP13 MCF2L

2.49e-0468844SM00325
DomainCRAL-TRIO_dom

TRIO MCF2L2 MCF2L

2.65e-0428843IPR001251
DomainRhoGEF

TRIO MCF2L2 AKAP13 MCF2L

2.78e-0470844PF00621
DomainDH_2

TRIO MCF2L2 AKAP13 MCF2L

2.78e-0470844PS50010
DomainDH-domain

TRIO MCF2L2 AKAP13 MCF2L

2.94e-0471844IPR000219
Domain-

TRIO MCF2L2 AKAP13 MCF2L

2.94e-04718441.20.900.10
DomainSpectrin_repeat

TRIO DMD MCF2L

2.95e-0429843IPR002017
DomainLNS2

LPIN1 LPIN2

2.96e-046842PF08235
DomainLNS2

LPIN1 LPIN2

2.96e-046842IPR013209
DomainLNS2

LPIN1 LPIN2

2.96e-046842SM00775
DomainLNS2/PITP

LPIN1 LPIN2

2.96e-046842IPR031315
DomainPTPc

PTPRD PTPRF PTPRS

5.63e-0436843SM00194
DomainTYR_PHOSPHATASE_PTP

PTPRD PTPRF PTPRS

7.14e-0439843PS50055
DomainPTPase_domain

PTPRD PTPRF PTPRS

8.27e-0441843IPR000242
DomainY_phosphatase

PTPRD PTPRF PTPRS

8.27e-0441843PF00102
DomainProt-tyrosine_phosphatase-like

PTPRD PTPRF PTPRS MTMR10

1.04e-0399844IPR029021
DomainCRAL_TRIO_2

MCF2L2 MCF2L

1.28e-0312842PF13716
DomainPH

TRIO DOCK11 MCF2L2 AKAP13 MCF2L MPRIP

1.59e-03278846SM00233
DomainPH_DOMAIN

TRIO DOCK11 MCF2L2 AKAP13 MCF2L MPRIP

1.62e-03279846PS50003
DomainPH_domain

TRIO DOCK11 MCF2L2 AKAP13 MCF2L MPRIP

1.65e-03280846IPR001849
DomainCyt_P450_CS

CYP3A7 CYP3A4 CYP3A43

1.75e-0353843IPR017972
DomainDynein_heavy_chain_D4_dom

DYNC1H1 DNAH14

1.76e-0314842IPR024317
DomainDynein_HC_stalk

DYNC1H1 DNAH14

1.76e-0314842IPR024743
DomainZnf_UBP

USP45 USP33

1.76e-0314842IPR001607
DomainMT

DYNC1H1 DNAH14

1.76e-0314842PF12777
DomainAAA_8

DYNC1H1 DNAH14

1.76e-0314842PF12780
Domainzf-UBP

USP45 USP33

1.76e-0314842PF02148
DomainZF_UBP

USP45 USP33

1.76e-0314842PS50271
DomainDHC_fam

DYNC1H1 DNAH14

2.02e-0315842IPR026983
DomainDynein_heavy_dom

DYNC1H1 DNAH14

2.02e-0315842IPR004273
DomainDynein_heavy

DYNC1H1 DNAH14

2.02e-0315842PF03028
DomainCYTOCHROME_P450

CYP3A7 CYP3A4 CYP3A43

2.16e-0357843PS00086
Domainp450

CYP3A7 CYP3A4 CYP3A43

2.27e-0358843PF00067
DomainPTPc_motif

PTPRD PTPRF PTPRS

2.38e-0359843SM00404
DomainTyr_Pase_cat

PTPRD PTPRF PTPRS

2.38e-0359843IPR003595
DomainCyt_P450

CYP3A7 CYP3A4 CYP3A43

2.50e-0360843IPR001128
DomainPH

TRIO DOCK11 AKAP13 MCF2L MPRIP

3.73e-03229845PF00169
DomainC2

CC2D2A CC2D1A PRKCQ PLCE1

3.86e-03142844PS50004
DomainTyr_Pase_AS

PTPRD PTPRF PTPRS

4.35e-0373843IPR016130
Domain-

CC2D2A CC2D1A PRKCQ PLCE1

4.47e-031488442.60.40.150
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PTPRD PTPRF PTPRS

9.19e-0520633M27290
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

PTPRD PTPRF PTPRS

9.19e-0520633MM15485
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PTPRD PTPRF PTPRS

9.19e-0520633MM14991
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

PTPRD PTPRF PTPRS

1.07e-0421633M27736
PathwayWP_GNAQ_PATHWAYS_IN_PORTWINE_STAIN

TRIO MAP2K1 MAP2K2

1.07e-0421633M48342
PathwayREACTOME_XENOBIOTICS

CYP3A7 CYP3A4 CYP3A43

1.41e-0423633M5372
PathwayREACTOME_PREDNISONE_ADME

CYP3A4 CYP3A43 ALB

1.41e-0423633MM16639
PathwayWP_TCELL_ANTIGEN_RECEPTOR_TCR_PATHWAY_DURING_STAPHYLOCOCCUS_AUREUS_INFECTION

PRKCQ IKBKB MAP2K1 MAP2K2

1.66e-0462634M39429
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_BRAF_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.95e-045632M49016
PathwayKEGG_LINOLEIC_ACID_METABOLISM

CYP3A7 CYP3A4 CYP3A43

2.86e-0429633M2920
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAP2K1 MAP2K2

2.91e-046632M27559
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAP2K1 MAP2K2

2.91e-046632MM15273
PathwayKEGG_MEDICUS_PATHOGEN_YERSINIA_YOPP_J_TO_TLR2_4_MAPK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.91e-046632M47636
PathwayWP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

OAS2 PRKCQ IKBKB PLCE1

3.47e-0475634M39568
PathwayPID_NETRIN_PATHWAY

TRIO MAP2K1 MAP2K2

3.85e-0432633M108
PathwayBIOCARTA_ACETAMINOPHEN_PATHWAY

CYP3A4 CYP3A43

5.41e-048632MM1547
PathwayPID_GMCSF_PATHWAY

IKBKB MAP2K1 MAP2K2

5.47e-0436633M22
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

TRIO AKAP13 MCF2L IKBKB

5.59e-0485634MM14746
PathwayWP_TCELL_ACTIVATION_SARSCOV2

PRKCQ IKBKB MAP2K1 MAP2K2

6.38e-0488634M42580
PathwayWP_KISSPEPTINKISSPEPTIN_RECEPTOR_SYSTEM_IN_THE_OVARY

PRKCQ MAP2K1 MAP2K2

6.93e-0439633M39905
PathwayWP_ETHANOL_METABOLISM_PRODUCTION_OF_ROS_BY_CYP2E1

MAP2K1 MAP2K2

6.93e-049632M39481
PathwayWP_TCELL_RECEPTOR_SIGNALING

PRKCQ IKBKB MAP2K1 MAP2K2

6.94e-0490634M39725
PathwayWP_INSULIN_SIGNALING

PTPRF PRKCQ IKBKB MAP2K1 MAP2K2

7.32e-04160635MM15956
PathwayWP_INSULIN_SIGNALING

PTPRF PRKCQ IKBKB MAP2K1 MAP2K2

7.32e-04160635M39482
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.64e-0410632M47374
PathwayKEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.64e-0410632M47420
PathwayWP_ETHANOL_METABOLISM_RESULTING_IN_PRODUCTION_OF_ROS_BY_CYP2E1

MAP2K1 MAP2K2

8.64e-0410632MM15821
PathwayKEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.64e-0410632M47735
PathwayREACTOME_PREDNISONE_ADME

CYP3A4 ALB

8.64e-0410632M46430
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

TRIO AKAP13 MCF2L IKBKB

9.20e-0497634M9400
PathwayWP_IL11_SIGNALING

IKBKB MAP2K1 MAP2K2

9.89e-0444633M39716
PathwayREACTOME_NETRIN_1_SIGNALING

TRIO SLIT1 PRKCQ

9.89e-0444633M875
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.05e-0311632M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.05e-0311632M47371
PathwayREACTOME_UPTAKE_AND_FUNCTION_OF_ANTHRAX_TOXINS

MAP2K1 MAP2K2

1.05e-0311632M27420
PathwayREACTOME_ASPIRIN_ADME

CYP3A4 CYP3A43 ALB

1.06e-0345633MM15694
PathwayBIOCARTA_KERATINOCYTE_PATHWAY

PRKCQ IKBKB MAP2K1

1.13e-0346633M19118
PathwayBIOCARTA_KERATINOCYTE_PATHWAY

PRKCQ IKBKB MAP2K1

1.13e-0346633MM1428
PathwayPID_RHOA_REG_PATHWAY

TRIO AKAP13 MCF2L

1.13e-0346633M68
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.26e-0312632M47369
PathwayKEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.26e-0312632M47597
PathwayREACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA

LPIN1 LPIN2

1.26e-0312632MM15105
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.26e-0312632M47815
PathwayREACTOME_SYNTHESIS_OF_PE

LPIN1 LPIN2

1.26e-0312632MM14586
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

LPIN1 LPIN2

1.26e-0312632MM15447
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP3A4 CYP3A43

1.26e-0312632MM15616
PathwayWP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY

IKBKB MAP2K1 MAP2K2

1.35e-0349633M39543
PathwayKEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY

PRKCQ IKBKB MAP2K1 MAP2K2

1.37e-03108634M9904
PathwayKEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.49e-0313632M47589
PathwayBIOCARTA_CDK5_PATHWAY

MAP2K1 MAP2K2

1.49e-0313632M89
PathwayREACTOME_SYNTHESIS_OF_PE

LPIN1 LPIN2

1.49e-0313632M656
PathwayWP_OSTEOPONTIN_SIGNALING

IKBKB MAP2K1

1.49e-0313632M39603
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

CYP3A7 CYP3A4 CYP3A43

1.52e-0351633M17726
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

TRIO AKAP13 MCF2L

1.61e-0352633MM14743
PathwayBIOCARTA_BARR_MAPK_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M668
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M47366
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M47378
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M47384
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

LPIN1 LPIN2

1.73e-0314632M619
PathwayREACTOME_PROLONGED_ERK_ACTIVATION_EVENTS

MAP2K1 MAP2K2

1.73e-0314632M622
PathwayREACTOME_PROLONGED_ERK_ACTIVATION_EVENTS

MAP2K1 MAP2K2

1.73e-0314632MM14667
PathwayBIOCARTA_CDK5_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632MM1457
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632M47488
PathwayBIOCARTA_BARR_MAPK_PATHWAY

MAP2K1 MAP2K2

1.73e-0314632MM1489
PathwayWP_IL1_SIGNALING

IKBKB MAP2K1 MAP2K2

1.89e-0355633M39346
PathwayWP_CARDIAC_HYPERTROPHIC_RESPONSE

IKBKB MAP2K1 MAP2K2

1.89e-0355633M39685
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

CYP3A7 CYP3A4 CYP3A43

1.89e-0355633M14933
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47367
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47375
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47382
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47380
PathwayREACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA

LPIN1 LPIN2

1.99e-0315632M27360
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47474
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.99e-0315632M47531
PathwayREACTOME_ATORVASTATIN_ADME

CYP3A4 CYP3A43

1.99e-0315632MM15697
PathwayREACTOME_NETRIN_1_SIGNALING

TRIO PRKCQ

1.99e-0315632MM14965
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

CST1 CST2 CST4 ALB

2.02e-03120634MM14982
PathwayKEGG_ACUTE_MYELOID_LEUKEMIA

IKBKB MAP2K1 MAP2K2

2.10e-0357633M19888
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.27e-0316632M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.27e-0316632M47373
PathwayREACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION

IKBKB MAP2K1

2.27e-0316632M27567
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.27e-0316632M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.27e-0316632M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.27e-0316632M47801
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

MAP2K1 MAP2K2

2.27e-0316632M39882
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.27e-0316632M47483
Pubmed

LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.

PTPRD PTPRF PTPRS

1.41e-08385331985401
Pubmed

Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.

PTPRD PTPRF PTPRS

1.41e-08385320139422
Pubmed

Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.

PTPRD PTPRF PTPRS

1.41e-0838539784606
Pubmed

Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.

PTPRD PTPRF PTPRS

1.41e-08385333656439
Pubmed

Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry.

CST1 CST2 CST4

1.41e-0838531898352
Pubmed

Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal gland of the rat.

CST1 CST2 CST4

1.41e-0838531471486
Pubmed

Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.

CST1 CST2 CST4

1.41e-0838531778989
Pubmed

The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.

PTPRD PTPRF PTPRS

5.63e-0848538524829
Pubmed

Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T.

CST1 CST2 CST4

5.63e-08485310713450
Pubmed

Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.

CST1 CST2 CST4

5.63e-08485313679380
Pubmed

Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells.

CST1 CST2 CST4

1.40e-07585323671283
Pubmed

Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation.

CST1 CST2 CST4

1.40e-07585317592728
Pubmed

Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation.

CST1 CST2 CST4

1.40e-07585332616516
Pubmed

HIV-1 Tat increases endothelial solute permeability through tyrosine kinase and mitogen-activated protein kinase-dependent pathways.

ALB MAP2K1 MAP2K2

1.40e-07585310780709
Pubmed

Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice.

CST1 CST2 CST4

1.40e-07585334440840
Pubmed

Transforming growth factor beta regulates cystatin C in serum-free mouse embryo (SFME) cells.

CST1 CST2 CST4

1.40e-0758532241983
Pubmed

Strong conservation of the expression of cystatin C gene in choroid plexus.

CST1 CST2 CST4

1.40e-0758531636787
Pubmed

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

CYP3A7 CYP3A4 CYP3A43

1.40e-07585311266076
Pubmed

Gene deletion of cystatin C aggravates brain damage following focal ischemia but mitigates the neuronal injury after global ischemia in the mouse.

CST1 CST2 CST4

1.40e-07585315450354
Pubmed

Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development.

CST1 CST2 CST4

1.40e-07585321443774
Pubmed

Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis.

CST1 CST2 CST4

1.40e-07585327079462
Pubmed

Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.

CST1 CST2 CST4

1.40e-07585310748866
Pubmed

Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice.

CST1 CST2 CST4

1.40e-07585315823274
Pubmed

Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice.

CST1 CST2 CST4

1.40e-07585321085595
Pubmed

Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation.

CST1 CST2 CST4

1.40e-07585334914637
Pubmed

A neurosphere-derived factor, cystatin C, supports differentiation of ES cells into neural stem cells.

CST1 CST2 CST4

1.40e-07585316595632
Pubmed

Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation.

CST1 CST2 CST4

1.40e-07585320489058
Pubmed

Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.

PTPRD PTPRF PTPRS

1.40e-07585310777529
Pubmed

Neuroprotection mediated by cystatin C-loaded extracellular vesicles.

CST1 CST2 CST4

1.40e-07585331367000
Pubmed

Up-regulation of cystatin C expression in the murine hippocampus following perforant path transections.

CST1 CST2 CST4

1.40e-07585312044447
Pubmed

FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor.

CST1 CST2 CST4

1.40e-07585311144350
Pubmed

Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.

PTPRD PTPRF PTPRS

1.40e-07585322357843
Pubmed

Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution.

CST1 CST2 CST4

1.40e-0758538761177
Pubmed

Cystatin C triggers neuronal degeneration in a model of multiple system atrophy.

CST1 CST2 CST4

1.40e-07585324405769
Pubmed

Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide.

CST1 CST2 CST4

1.40e-07585314742906
Pubmed

Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease.

CST1 CST2 CST4

1.40e-07585319773092
Pubmed

Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis.

CST1 CST2 CST4

1.40e-07585333754041
Pubmed

Developmental regulation of synthesis and dimerization of the amyloidogenic protease inhibitor cystatin C in the hematopoietic system.

CST1 CST2 CST4

1.40e-07585324570004
Pubmed

Loss of cystatin C regulates permeability and inflammatory pathways in retina.

CST1 CST2 CST4

1.40e-07585336822364
Pubmed

Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice.

CST1 CST2 CST4

1.40e-07585332467129
Pubmed

Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse.

CST1 CST2 CST4

1.40e-07585316242633
Pubmed

Carminerin contributes to chondrocyte calcification during endochondral ossification.

CST1 CST2 CST4

1.40e-07585316680148
Pubmed

Cystatin C Plays a Sex-Dependent Detrimental Role in Experimental Autoimmune Encephalomyelitis.

CST1 CST2 CST4

1.40e-07585333027652
Pubmed

pH-dependent and dynamic interactions of cystatin C with heparan sulfate.

CST1 CST2 CST4

1.40e-07585333580179
Pubmed

CST3 alleviates retinal vascular leakage by regulating the Rap1 signaling pathway.

CST1 CST2 CST4

1.40e-07585339147193
Pubmed

Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates.

CST1 CST2 CST4

1.40e-07585325329717
Pubmed

Fertility defects in mice expressing the L68Q variant of human cystatin C: a role for amyloid in male infertility.

CST1 CST2 CST4

1.40e-07585324500719
Pubmed

Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice.

CST1 CST2 CST4

1.40e-07585320472891
Pubmed

Control and expression of cystatin C by mouse decidual cultures.

CST1 CST2 CST4

1.40e-07585311803549
Pubmed

Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice.

CST1 CST2 CST4

2.80e-07685316051881
Pubmed

Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.

PTPRD PTPRF PTPRS

2.80e-07685319273906
Pubmed

The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation.

CST1 CST2 CST4

2.80e-07685314607896
Pubmed

Epithelial cell-derived cytokines CST3 and GDF15 as potential therapeutics for pulmonary fibrosis.

CST1 CST2 CST4

2.80e-07685329724997
Pubmed

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity.

CST1 CST2 CST4

2.80e-07685325356866
Pubmed

Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors.

CST1 CST2 CST4

2.80e-07685316365041
Pubmed

Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland.

CST1 CST2 CST4

2.80e-07685311879580
Pubmed

Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy.

CST1 CST2 CST4

2.80e-07685320889561
Pubmed

Cystatin C modulates cerebral beta-amyloidosis.

CST1 CST2 CST4

2.80e-07685318026102
Pubmed

Cystatin C attenuates insulin signaling transduction by promoting endoplasmic reticulum stress in hepatocytes.

CST1 CST2 CST4

2.80e-07685326592151
Pubmed

Megalin-mediated endocytosis of cystatin C in proximal tubule cells.

CST1 CST2 CST4

2.80e-07685317462596
Pubmed

Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines.

CST1 CST2 CST4

2.80e-07685320352108
Pubmed

Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.

CST1 CST2 CST4

2.80e-07685315653570
Pubmed

Macrophage responses to interferon-gamma are dependent on cystatin C levels.

CST1 CST2 CST4

2.80e-07685319446036
Pubmed

Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy.

CST1 CST2 CST4

2.80e-07685311472890
Pubmed

Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.

PTPRD PTPRF PTPRS

4.90e-07785329073098
Pubmed

Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.

PTPRD PTPRF PTPRS

4.90e-07785312376545
Pubmed

Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein.

CST1 CST2 CST4

4.90e-07785327693425
Pubmed

Cystatin C regulates major histocompatibility complex-II-peptide presentation and extracellular signal-regulated kinase-dependent polarizing cytokine production by bone marrow-derived dendritic cells.

CST1 CST2 CST4

4.90e-07785331513306
Pubmed

Structure, alternative splicing and chromosomal localization of the cystatin-related epididymal spermatogenic gene.

CST1 CST2 CST4

4.90e-07785310229662
Pubmed

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.

CST1 CST2 CST4

4.90e-07785318957217
Pubmed

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.

CYP3A7 CYP3A4 CYP3A43

4.90e-07785311137287
Pubmed

Structural organization, expression and chromosomal mapping of the mouse cystatin-C-encoding gene (Cst3).

CST1 CST2 CST4

4.90e-0778537835704
Pubmed

Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.

CST1 CST2 CST4

4.90e-07785323024364
Pubmed

IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.

CST1 CST2 CST4

4.90e-07785321300820
Pubmed

Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.

CST1 CST2 CST4

4.90e-07785318681831
Pubmed

Isolation of cystatin C via functional cloning of astrocyte differentiation factors.

CST1 CST2 CST4

4.90e-07785315509901
Pubmed

The embryo's cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S in mice.

CST1 CST2 CST4

7.82e-07885320093401
Pubmed

Genomic cloning, physical mapping, and expression of human type 2 cystatin genes.

CST1 CST2 CST4

7.82e-0788537690606
Pubmed

Isolation of novel mouse genes associated with ectopic ossification by differential display method using ttw, a mouse model for ectopic ossification.

CST1 CST2 CST4

7.82e-07885311856874
Pubmed

Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.

PTPRD PTPRF PTPRS

7.82e-07885337591863
Pubmed

Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.

PTPRD PTPRF PTPRS

7.82e-07885328637841
Pubmed

PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells.

PRKCQ MAP2K1 MAP2K2

7.82e-07885326973648
Pubmed

The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation.

CST1 CST2 CST4

7.82e-0788539310336
Pubmed

Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.

CYP3A4 CYP3A43 ALB

1.17e-0698533917435
Pubmed

Translational deregulation in PDK-1-/- embryonic stem cells.

CST1 CST2 CST4

1.17e-06985316166629
Pubmed

Induced expression of cathepsins and cystatin C in a murine model of demyelination.

CST1 CST2 CST4

1.17e-06985317086443
Pubmed

HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy.

IKBKB MAP2K1 MAP2K2

1.17e-06985323555914
Pubmed

Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2.

CST1 CST2 CST4

1.67e-06108537896273
Pubmed

Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.

CST1 CST2 CST4

1.67e-06108533202964
Pubmed

Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis.

CST1 CST2 CST4

1.67e-061085318723004
Pubmed

A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis.

CST1 CST2 CST4

2.29e-061185314516662
Pubmed

PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.

PTPRD PTPRF PTPRS

2.29e-061185325624497
Pubmed

A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.

PTPRD PTPRF PTPRS

2.29e-06118537832766
Pubmed

Testatin: a cystatin-related gene expressed during early testis development.

CST1 CST2 CST4

2.29e-06118539826679
Pubmed

Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development.

CYP3A4 CYP3A43 ALB

2.29e-061185327904043
Pubmed

Salivary protein profiles are linked to bitter taste acceptance in infants.

CST1 CST2 CST4

2.29e-061185324248522
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

PRKCQ MAP2K1 MAP2K2 PLCE1

2.30e-063885412482669
Pubmed

A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation.

CST1 CST2 CST4

3.05e-061285310707901
Pubmed

Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PTPRD PTPRF PTPRS

3.05e-06128539624153
Pubmed

Friends and relations of the cystatin superfamily--new members and their evolution.

CST1 CST2 CST4

3.05e-06128539007972
InteractionAKNAD1 interactions

CST1 CST2 CST4

1.39e-0512823int:AKNAD1
InteractionCRYGN interactions

CST1 CST2 CST4

1.39e-0512823int:CRYGN
InteractionTGFBR2 interactions

USP45 RAPSN PTPRD PTPRF PTPRS IKBKB MAP2K1 USP33

1.62e-05275828int:TGFBR2
InteractionOMG interactions

PTPRD PTPRF PTPRS

1.80e-0513823int:OMG
InteractionRHOBTB1 interactions

RRP1B CST1 CST2 CST4 MAP2K2 XPOT

3.64e-05152826int:RHOBTB1
InteractionKCNG4 interactions

CST1 CST2 CST4

5.07e-0518823int:KCNG4
InteractionRCAN1 interactions

PTPRD CST2 CST4 ZNF292

5.94e-0552824int:RCAN1
InteractionPLEKHG6 interactions

CST1 CST4 AKAP13 RAPGEFL1

6.41e-0553824int:PLEKHG6
InteractionDAZ2 interactions

CST1 CST2 CST4

8.19e-0521823int:DAZ2
InteractionTRIO interactions

ANKFY1 PTPRD PTPRF TRIO PTPRS

8.27e-05109825int:TRIO
InteractionCHAC2 interactions

CDKN2AIP CST1 CST4

9.46e-0522823int:CHAC2
InteractionZNF491 interactions

CST2 CST4 ALB

1.08e-0423823int:ZNF491
InteractionRCAN2 interactions

CST1 CST2 CST4

1.24e-0424823int:RCAN2
InteractionPDZRN4 interactions

LNX2 ALB

1.62e-045822int:PDZRN4
Cytoband20p11.21

CST1 CST2 CST4

3.21e-053385320p11.21
Cytoband7q21.1

CYP3A4 CYP3A43

9.42e-0588527q21.1
Cytoband4p15.32

PROM1 CC2D2A

4.00e-04168524p15.32
GeneFamilyCytochrome P450 family 3

CYP3A7 CYP3A4 CYP3A43

2.02e-0686131002
GeneFamilyCystatins, type 2

CST1 CST2 CST4

1.98e-0516613965
GeneFamilyLipins

LPIN1 LPIN2

3.35e-0536121043
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRD PTPRF PTPRS

4.65e-0521613813
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIO MCF2L2 AKAP13 MCF2L

7.23e-0566614722
GeneFamilyMitogen-activated protein kinase kinases

MAP2K1 MAP2K2

2.33e-047612653
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PTPRD PTPRF TRIO PTPRS

2.13e-03161614593
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOCK11 AKAP13 MCF2L MPRIP

5.15e-03206614682
CoexpressionXU_CREBBP_TARGETS_UP

PROM1 GBP7 RRP1B XPOT

6.87e-0722844M17669
CoexpressionXU_CREBBP_TARGETS_UP

PROM1 GBP7 RRP1B XPOT

8.30e-0723844MM641
CoexpressionGSE36527_CD69_NEG_VS_POS_TREG_CD62L_LOS_KLRG1_NEG_UP

ANKFY1 TRAFD1 GBP7 DDX60 OAS2 PRKCQ MAP2K1

3.74e-06200847M9030
CoexpressionGSE19888_CTRL_VS_TCELL_MEMBRANES_ACT_MAST_CELL_PRETREAT_A3R_INH_DN

SETDB2 ANKFY1 GBP7 DDX60 TPX2 OAS2 RAPGEFL1

3.74e-06200847M7336
CoexpressionVETTER_TARGETS_OF_PRKCA_AND_ETS1_DN

CST1 CST2 CST4

1.73e-0516843M11619
CoexpressionGSE40493_BCL6_KO_VS_WT_TREG_UP

USP45 TRIO RRP1B HACE1 LPIN2 DYNC1H1

2.29e-05177846M9401
CoexpressionLEIN_ASTROCYTE_MARKERS

CST1 CST2 CST4 ATP1A4

2.75e-0554844MM715
CoexpressionGSE34006_A2AR_KO_VS_A2AR_AGONIST_TREATED_TREG_UP

ANKFY1 TRAFD1 GBP7 DDX60 OAS2 MAP2K1

4.54e-05200846M9051
CoexpressionTABULA_MURIS_SENIS_BRAIN_NON_MYELOID_NEURON_AGEING

AGBL4 TRIO PTPRS CDKN2AIP CST1 CST2 CST4 AKAP13 CORO1B DMD MAP2K2 MTMR10

5.11e-059548412MM3689
CoexpressionTABULA_MURIS_SENIS_MESENTERIC_ADIPOSE_TISSUE_CD8_POSITIVE_ALPHA_BETA_T_CELL_AGEING

CST1 CST2 CST4

6.12e-0524843MM3779
CoexpressionTABULA_MURIS_SENIS_KIDNEY_KIDNEY_COLLECTING_DUCT_EPITHELIAL_CELL_AGEING

CST1 CST2 CST4

6.12e-0524843MM3723
CoexpressionBMI1_DN_MEL18_DN.V1_DN

PROM1 DDX60 GNPTAB PEG3 OGDHL

1.12e-04147845M2775
CoexpressionBOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE

TRAFD1 GBP7 DDX60 OAS2

1.17e-0478844M2532
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AGBL4 PROM1 PTPRD TRIO DOCK11 LPIN2

1.57e-061898463b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

AGBL4 PROM1 EFCAB6 EFCAB12 CCDC190 CFAP57

1.57e-0618984627329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 PROM1 DOCK11 SLIT1 MTMR10

1.24e-051588451cefb82b9bf79c687a119be568cfc15b14c6e040
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LPIN1 THEMIS KCNC1 SETD4 PRKCQ

1.76e-051708458e9b5f7bfb61f8d84d0b17fb0c191da4dabad63d
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

GBP7 CYP3A4 CYP3A43 ALB F12

1.97e-051748455aa2fb631505600f37d2b87b02def7be139dc262
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LPIN1 THEMIS KCNC1 SETD4 PRKCQ

2.02e-05175845f949613ee45f5d950578c512d197716855118d18
ToppCellCOVID-19-kidney-PCT-S3-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

GBP7 CYP3A4 CYP3A43 ALB F12

2.08e-05176845b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 PROM1 DOCK11 PRKCQ MTMR10

2.14e-05177845da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

AGBL4 PROM1 EFCAB6 CCDC190 CFAP57

2.44e-05182845fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LPIN1 CLEC4E PTPRF HACE1 ERCC6L2

2.51e-051838456e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 PROM1 DOCK11 PRKCQ MTMR10

2.51e-05183845cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRD EFCAB6 DMD ATP1A4 PLCE1

2.57e-051848452cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRD EFCAB6 DMD ATP1A4 PLCE1

2.57e-05184845ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRD EFCAB6 DMD ATP1A4 PLCE1

2.57e-051848452b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 PTPRD CDKN2AIP DMD XPOT

2.64e-051858459878392d79734ab5bb977d7f4f5e2e079b9a5353
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

AGBL4 PROM1 EFCAB6 CCDC190 CFAP57

2.64e-0518584518a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

ANKFY1 DDX60 LPIN2 OAS2 KLHL41

2.85e-051888456f8946d4710f6e32c937213f99b790b098b8819c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 TRIO DOCK11 PRKCQ DNAH14

2.85e-0518884563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellfacs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AGBL4 RAPSN PEG3 PRKCQ DMD

2.85e-05188845794fc1d9a726945c42f7eac221eed938309b47a9
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

AGBL4 EFCAB6 EFCAB12 CCDC190 CFAP57

2.93e-0518984568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

AGBL4 EFCAB6 EFCAB12 CCDC190 CFAP57

2.93e-05189845b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PROM1 CCDC190 CC2D2A PLCE1 HELLS

3.08e-05191845683e5c7e6173644f01e67c98ab7b75d7cb9cce99
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 TRIO DOCK11 MTMR10 DNAH14

3.08e-05191845d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AGBL4 PROM1 PTPRD TRIO DOCK11

3.08e-051918451cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AGBL4 PROM1 EFCAB6 CCDC190 CFAP57

3.08e-05191845e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AGBL4 PROM1 EFCAB6 CCDC190 CFAP57

3.08e-051918459d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AGBL4 PROM1 EFCAB6 CCDC190 CFAP57

3.08e-051918451c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EFCAB6 EFCAB12 CCDC190 CC2D2A CFAP57

3.32e-051948451ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 THBS2 PTPRD DOCK11 LPIN2

3.32e-0519484570185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AGBL4 PROM1 EFCAB6 EFCAB12 CFAP57

3.32e-051948454a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

ANKFY1 TRAFD1 DDX60 LPIN2 OAS2

3.40e-05195845b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellBLOOD--(1)_Activated_T_cells| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CDCA2 TPX2 CORO1B MPRIP HELLS

3.40e-0519584545515d5da8a8c8242eb70a1bea24fe44eca5407b
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

THEMIS DDX60 LPIN2 PRKCQ MPRIP

3.40e-0519584522191d361af136942508f1553ff41a626ed982ad
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS2 ABRAXAS1 PEG3 LPIN2 PLCE1

3.48e-05196845308fa54385ca34e9e590967d4553b84aad96c92f
ToppCellMild-CD8+_T_activated|World / Disease group and Cell class

THEMIS TRAFD1 DDX60 LPIN2 OAS2

3.48e-0519684579632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCellCV-Moderate-1|CV / Virus stimulation, Condition and Cluster

TRAFD1 DDX60 GNPTAB LPIN2 OAS2

3.57e-05197845e3d00d850b4d191f9592ef993c0eaadfe5710b5f
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AGBL4 EFCAB6 EFCAB12 CFAP57 DMD

3.57e-0519784574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellMild-CD8+_T_activated|Mild / Disease group and Cell class

THEMIS TRAFD1 DDX60 LPIN2 OAS2

3.65e-05198845ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

CDCA2 THEMIS DDX60 LPIN2 OAS2

3.65e-05198845ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PROM1 RAPSN PEG3 KLHL41 DMD

3.74e-05199845e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS2 ABRAXAS1 PEG3 LPIN2 PLCE1

3.74e-05199845eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PROM1 RAPSN PEG3 KLHL41 DMD

3.74e-05199845801887db51ac5dc5b068808ff75e3a46643398e9
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

AGBL4 PROM1 EFCAB6 EFCAB12 CFAP57

3.83e-0520084596701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AGBL4 PROM1 EFCAB12 CCDC190 CFAP57

3.83e-0520084585c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DOCK11 DMD ATP1A4 MPRIP PLCE1

3.83e-05200845b22cae282591d8dead9869c2adbb9632615f50f7
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm|GW13 / Sample Type, Dataset, Time_group, and Cell type.

LPIN1 ANKFY1 PHRF1 SETD4 MTMR10

3.83e-052008450f4b8b0868bda406fe6bf01d1b722510fdfd0168
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DDX60 OAS2 AKAP13 DYNC1H1 ZNF292

3.83e-0520084512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

THEMIS DDX60 LPIN2 OAS2 MPRIP

3.83e-05200845d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AGBL4 PROM1 EFCAB12 CCDC190 CFAP57

3.83e-0520084512bc7d95c4166d12487081a76d210b7abe5991b0
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

THEMIS KCNC1 EFCAB12 USP33

8.67e-05123844511b7c20a4a85e49980936d52af7dbca19bb848e
ToppCellPericytes-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

THBS2 PTPRD SLIT1 TPX2

1.86e-04150844dbc202bd6db4fb5c8b2abd1200e074a2a9e63a59
ToppCellInfluenza_Severe-Treg|Influenza_Severe / Disease group and Cell class

CDKN2AIP MCF2L2 PRKCQ MCF2L

2.06e-0415484477845bcb243aa1b1f1ca00f9ef2ae1b4d1bd3696
ToppCellfacs-BAT-Fat-18m-Lymphocytic-NK_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPIN1 THEMIS GNPTAB PRKCQ

2.62e-04164844ab9c17f86b98e1a4d5db1bd3086edab1320ebda8
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CMPK1 TRAFD1 CORO1B MAP2K1

2.62e-04164844f88871d3b9307112eb7ced4c629f5704326ecae8
ToppCellsevere-unassigned|World / disease stage, cell group and cell class

NUS1 SETD4 F12 ZNF181

2.62e-04164844b3a45c150df6594debeeca400cc58d30ef662756
ToppCellsevere-unassigned|severe / disease stage, cell group and cell class

NUS1 SETD4 F12 ZNF181

2.68e-04165844f9ddd547992fec065d539a1d0305acba8fc7d79c
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CDCA2 AGBL4 TCERG1L SLIT1

2.80e-04167844c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|356C / Donor, Lineage, Cell class and subclass (all cells)

THEMIS TCERG1L LPIN2 AKAP13

2.87e-041688449d6ca10c272aea28082c09d469940f7232f6461c
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDCA2 AGBL4 PTPRD TPX2

2.93e-04169844563c267edaade0e5df192ad953801ef9768d4270
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AGBL4 EFCAB6 EFCAB12 CFAP57

2.93e-04169844fba841664939c771881ba97f14ef1df6635c04ff
ToppCellICU-NoSEP-Lymphocyte-T_NK-CD4_CTL|ICU-NoSEP / Disease, Lineage and Cell Type

CMPK1 THEMIS CCDC190 PRKCQ

2.93e-04169844cbda36f32bd78322dcfe303a44413415d08e5ea3
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PROM1 SLIT1 CCDC190 CFAP57

2.93e-0416984414aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THEMIS GBP7 DDX60 PRKCQ

3.07e-04171844a8adce007ff4c713f71f2359b40cb3575b28c98d
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAPSN GBP7 DDX60 OAS2

3.14e-04172844714172f31abd0d25261df6115ec6a9df491fa14b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EFCAB12 TPX2 MAP2K1 HELLS

3.21e-041738449f892d756d05e573af018db64edb130ff187ad47
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDCA2 TPX2 MCF2L HELLS

3.28e-04174844c988471207ba06195bc3e41056435e8c31c20bbe
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

THEMIS TCERG1L AKAP13 CORO1B

3.28e-0417484499d7421ad5eafe7751ef90698a92f683aa33bca8
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDCA2 TPX2 CC2D2A PLCE1

3.28e-0417484441eb0a214a8b4015a26311f77061c8147144f0e7
ToppCellNS-critical-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PROM1 EFCAB12 CCDC190 CFAP57

3.42e-04176844b794275fdd757b8fa2108e3c867f23da2649146d
ToppCellfacs-Spleen-nan-18m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPIN1 THEMIS GBP7 PRKCQ

3.42e-04176844a23d484aff5ad094333b2feae9106ca219514711
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

LPIN1 DDX60 GNPTAB NUS1

3.42e-041768443de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CLEC4E LNX2 PTPRD MCF2L2

3.50e-04177844946803293a7955116c80f403e99e4093e798ca3f
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-mature_NK_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPIN1 THEMIS KCNC1 PRKCQ

3.50e-0417784452402ff6299210c46fd9dee3cef203c0eda7a98a
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDCA2 TPX2 PRKCQ HELLS

3.50e-04177844f10f77130dbb2c0ad1b436ceb4fb1deac2b0267c
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

AGBL4 PTPRF DOCK11 PTPRS

3.50e-04177844f0edf04930692418953e4f00a917257804ec0ffd
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS2 PTPRD TRIO PEG3

3.50e-041778447af1a19692f7fe8f691178a4e57d62bc379e3d56
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THEMIS OR52A5 SLIT1 PRKCQ

3.50e-0417784401df8ab3285fa66b4805c555cfbfc4b3b16db919
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THEMIS SLIT1 AKAP13 MAP2K1

3.57e-04178844b169aa5eaa51730daaec69c6bc58126be1592a50
ToppCellRV-11._Adipocyte|RV / Chamber and Cluster_Paper

AGBL4 PTPRF DOCK11 PTPRS

3.57e-04178844278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 PROM1 DOCK11 MTMR10

3.57e-04178844c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

PROM1 PTPRD PLCE1 HELLS

3.57e-0417884435a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

DDX60 LPIN2 OAS2 KLHL41

3.65e-04179844af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THEMIS SLIT1 AKAP13 DNAH14

3.65e-04179844747a32460b257fffca30527b56a74720eb9c12e4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THEMIS SLIT1 DMD DNAH14

3.65e-041798441ac79c82c52fa95bb4e170ab20fec0f648db2134
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PROM1 PTPRS PEG3 DMD

3.65e-0417984402c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CDCA2 AGBL4 TPX2 HELLS

3.72e-04180844f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PROM1 PTPRF TRIO PTPRS

3.72e-04180844e4add4c94f892a2d93926e5c6dac6a738319d091
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 PROM1 DOCK11 MTMR10

3.80e-041818446a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

THBS2 PTPRD CST1 CST2

3.80e-04181844bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 PROM1 DOCK11 MTMR10

3.80e-04181844071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellfacs-Marrow-T-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRF PTPRS ALB IKBKB

3.80e-041818447286700396676fdc41d9723979b8b408177aceb9
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AGBL4 PTPRS SLIT1 F12

3.80e-041818447f99002a6411117cc2361334c7c9228e20c574b4
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

AGBL4 EFCAB6 EFCAB12 CFAP57

3.80e-04181844dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THEMIS SLIT1 AKAP13 DMD

3.88e-04182844205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 DOCK11 PRKCQ MCF2L

3.88e-04182844eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LPIN1 PROM1 DOCK11 MTMR10

3.96e-04183844738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

AGBL4 LPIN1 PTPRF DOCK11

3.96e-04183844b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

AGBL4 LPIN1 PTPRF DOCK11

3.96e-041838443f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PROM1 PTPRS PEG3 DMD

3.96e-041838447eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

TRIO DDX60 OAS2 ZNF292

3.96e-041838448f7f5000645f24f20a8d7700c4df1f8953a1780b
DrugPD 0325901

CYP3A7 CYP3A4 PEG3 ALB MAP2K1 MAP2K2

4.08e-06114846ctd:C506614
DrugMangifera indica extract

CYP3A4 ALB IKBKB MAP2K1

5.73e-0632844ctd:C501277
DrugBezafibrate [41859-67-0]; Down 200; 11uM; PC3; HT_HG-U133A

LPIN1 ANKFY1 TRAFD1 TRIO DDX60 CST1 IKBKB

8.14e-061968476653_DN
DrugAC1L1CJI

CYP3A7 CYP3A4 CYP3A43 ALB

8.27e-0635844CID000001929
DrugTAK 733

MAP2K1 MAP2K2

1.35e-052842ctd:C558666
DrugMethacrol 2138F

ALB F12

1.35e-052842CID000161664
DrugSulfoglycosphingolipids

ALB F12

1.35e-052842ctd:D013433
Druggemfibrozil glucuronide

ALB MCF2L

1.35e-052842CID000088127
DrugN-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

MAP2K1 MAP2K2

1.35e-052842ctd:C544830
Drug2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide

CYP3A7 CYP3A4 MAP2K1 MAP2K2

2.96e-0548844ctd:C120227
Drugnaphthalene epoxide

CYP3A7 CYP3A4 CYP3A43 ALB

3.77e-0551844CID000108063
DrugAC1L1SX8

CYP3A7 CYP3A4 CYP3A43

3.80e-0518843CID000060278
Drug17-hydroxypregnenolone sulfate

CYP3A7 CYP3A4

4.03e-053842CID000152971
DrugRO5126766

MAP2K1 MAP2K2

4.03e-053842ctd:C577924
Drugrabeprazole

CYP3A7 CYP3A4 CYP3A43

4.50e-0519843CID000005029
DiseaseColorectal Carcinoma

LPIN1 PROM1 TCERG1L PTPRD PTPRS PEG3 MCF2L2 TPX2 SETD4 CORO1B DMD ZNF292

6.20e-077028312C0009402
Diseaseepiandrosterone sulfate measurement

CYP3A7 CYP3A4 CYP3A43 MAP2K2

7.04e-0725834EFO_0021120
Diseasecystatin-SN measurement

CST1 CST2 CST4

1.78e-069833EFO_0008106
Diseasecystatin-D measurement

CST1 CST2 CST4

1.42e-0517833EFO_0008103
Diseasemetabolonic lactone sulfate measurement

CYP3A7 CYP3A4 CYP3A43

2.01e-0519833EFO_0800659
Diseasemyoglobinuria (implicated_via_orthology)

LPIN1 LPIN2

2.34e-053832DOID:0080108 (implicated_via_orthology)
Diseasesmall intestine adenocarcinoma (is_implicated_in)

MAP2K1 MAP2K2

2.34e-053832DOID:4906 (is_implicated_in)
Disease5alpha-androstan-3beta,17beta-diol disulfate measurement

CYP3A7 CYP3A4 PRKCQ

3.18e-0522833EFO_0021115
Diseasedehydroepiandrosterone sulphate measurement

CYP3A7 PTPRD CYP3A4 CYP3A43

4.13e-0568834EFO_0007001
Diseasetacrolimus measurement

CYP3A7 CYP3A4

4.67e-054832EFO_0008458
Diseaseestrone conjugate measurement

CYP3A7 CYP3A4

4.67e-054832EFO_0007971
Diseaseazoospermia (implicated_via_orthology)

PTPRD PTPRF PTPRS

5.98e-0527833DOID:14227 (implicated_via_orthology)
Diseasetauro-beta-muricholate measurement

CYP3A7 CYP3A4

7.77e-055832EFO_0800213
Diseaseglyco-beta-muricholate measurement

CYP3A7 CYP3A4

7.77e-055832EFO_0800569
Diseasenephrotic syndrome (is_implicated_in)

ALB PLCE1

7.77e-055832DOID:1184 (is_implicated_in)
Diseaseintellectual disability (is_implicated_in)

CC2D2A CC2D1A DMD

8.25e-0530833DOID:1059 (is_implicated_in)
Diseaseandrosterone sulfate measurement

CYP3A7 CYP3A4 MAP2K2

1.10e-0433833EFO_0021117
Diseasedehydroisoandrosterone sulfate DHEA-S measurement

CYP3A7 CYP3A4

1.16e-046832EFO_0021119
Diseaseandrostenediol (3beta,17beta) monosulfate (1) measurement

CYP3A7 CYP3A4

1.16e-046832EFO_0800294
Diseasecystatin C measurement

SETDB2 RAPSN TRAFD1 CST1 CST2 CST4 F12

1.41e-04402837EFO_0004617
DiseaseX-24574 measurement

CYP3A7 CYP3A4

1.63e-047832EFO_0800897
Diseasecystatin-SA measurement

CST1 CST4

2.16e-048832EFO_0008105
DiseaseRASopathy (implicated_via_orthology)

MAP2K1 MAP2K2

2.78e-049832DOID:0080690 (implicated_via_orthology)
Diseaseandrostenediol (3beta,17beta) disulfate (1) measurement

CYP3A7 CYP3A4

2.78e-049832EFO_0800278
Disease4-androsten-3alpha,17alpha-diol monosulfate (3) measurement

CYP3A7 CYP3A4

3.47e-0410832EFO_0022090
Disease5alpha-androstan-3beta,17alpha-diol disulfate measurement

CYP3A7 CYP3A4

3.47e-0410832EFO_0800289
DiseaseNoonan Syndrome 1

MAP2K1 MAP2K2

4.23e-0411832C4551602
DiseaseDNA repair protein RAD51 homolog 4 measurement

CYP3A7 CYP3A4

4.23e-0411832EFO_0801531
Diseasephosphatidylcholine 32:0 measurement

RAPSN PTPRD

4.23e-0411832EFO_0010372
DiseaseTurner Syndrome, Male

MAP2K1 MAP2K2

4.23e-0411832C0041409
DiseaseFemale Pseudo-Turner Syndrome

MAP2K1 MAP2K2

4.23e-0411832C1527404
Diseaseandrostenediol (3beta,17beta) monosulfate (2) measurement

CYP3A7 CYP3A4

4.23e-0411832EFO_0800295
Diseasemiddle cerebral artery infarction (is_implicated_in)

ALB F12

5.07e-0412832DOID:3525 (is_implicated_in)
Diseasemethionine sulfone measurement

CYP3A4 CYP3A43

5.07e-0412832EFO_0800072
Disease5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement

CYP3A7 CYP3A4

5.07e-0412832EFO_0800291
Diseaseandrostenediol (3alpha, 17alpha) monosulfate (3) measurement

CYP3A7 CYP3A4

5.98e-0413832EFO_0800293
Disease5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement

CYP3A7 CYP3A4

5.98e-0413832EFO_0800284
DiseaseX-21470 measurement

CYP3A7 CYP3A4

6.96e-0414832EFO_0800817
Diseaseunipolar depression, anxiety

PTPRD CDKN2AIP

6.96e-0414832EFO_0003761, EFO_0005230
Disease5alpha-androstan-3alpha,17alpha-diol monosulfate measurement

CYP3A7 CYP3A4

6.96e-0414832EFO_0800283
Diseasenon-lobar intracerebral hemorrhage

PTPRF CDKN2AIP DNAH14

7.55e-0463833EFO_0010178
Disease16a-hydroxy DHEA 3-sulfate measurement

CYP3A7 CYP3A4

8.02e-0415832EFO_0800301
Diseaselipid metabolism disorder (implicated_via_orthology)

LPIN1 LPIN2

8.02e-0415832DOID:3146 (implicated_via_orthology)
DiseaseUnipolar Depression

PROM1 OAS2 CC2D1A ALB MAP2K1

8.33e-04259835C0041696
DiseaseDiabetic Angiopathies

THBS2 ALB

9.14e-0416832C0011875
DiseaseMicroangiopathy, Diabetic

THBS2 ALB

9.14e-0416832C0025945
DiseaseX-21410 measurement

CYP3A7 CYP3A4

9.14e-0416832EFO_0800813
Diseaseandro steroid monosulfate C19H28O6S (1) measurement

CYP3A7 CYP3A4

9.14e-0416832EFO_0800305
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

TRIO ZNF292

1.03e-0317832DOID:0060307 (is_implicated_in)
Disease5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement

CYP3A7 CYP3A4

1.16e-0318832EFO_0800288
Diseaseepilepsy (implicated_via_orthology)

TRIO NUS1 ATP1A4 DYNC1H1

1.17e-03163834DOID:1826 (implicated_via_orthology)
Diseasephosphatidylcholine measurement

AGBL4 RAPSN PRKCQ ALB DYNC1H1

1.26e-03284835EFO_0010226
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

MAP2K1 MAP2K2

1.30e-0319832C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

MAP2K1 MAP2K2

1.30e-0319832C1843181
DiseaseCardio-facio-cutaneous syndrome

MAP2K1 MAP2K2

1.30e-0319832C1275081
DiseaseCostello syndrome (disorder)

MAP2K1 MAP2K2

1.30e-0319832C0587248
Diseaseetiocholanolone glucuronide measurement

CYP3A7 CYP3A4

1.30e-0319832EFO_0800362
Diseaseandrosterone glucuronide measurement

CYP3A7 CYP3A4

1.44e-0320832EFO_0800317
Diseasegestational age, birth measurement

RAPSN PTPRD

1.59e-0321832EFO_0005112, EFO_0006921
DiseaseLEOPARD Syndrome

MAP2K1 MAP2K2

1.74e-0322832C0175704
DiseaseX-24947 measurement

CYP3A7 CYP3A4

1.74e-0322832EFO_0800910
DiseaseAttention deficit hyperactivity disorder

PTPRD ZNF292

2.07e-0324832C1263846
Diseaseaspartate measurement

GNPTAB F12

2.07e-0324832EFO_0010462
Diseasetemperament and character inventory

TCERG1L PTPRD

2.07e-0324832EFO_0004825
DiseaseNoonan Syndrome

MAP2K1 MAP2K2

2.07e-0324832C0028326
Diseasebirth weight, parental genotype effect measurement

CYP3A7 CYP3A4 AKAP13 PLCE1

2.14e-03192834EFO_0004344, EFO_0005939
Diseaseresponse to interferon

TCERG1L PLCE1

2.25e-0325832EFO_0007859
Diseasegout

TRAFD1 PTPRD CDKN2AIP ATP1A4

2.30e-03196834EFO_0004274

Protein segments in the cluster

PeptideGeneStartEntry
QKDPQENIFLCQALR

ABRAXAS1

271

Q6UWZ7
AKQEPERNECFLQHK

ALB

116

P02768
PQKQCREEVLKNFTD

AGO1

456

Q9UL18
QERADFCPFKVVDNK

AKAP13

726

Q12802
KFRHVFGQPVKNDQC

CORO1B

11

Q9BR76
CFQFANNKPEIEAAL

DMD

3266

P11532
CFKQFQQKDFRLPQT

EFCAB12

41

Q6NXP0
DFVNKCLIKNPAERA

MAP2K1

336

Q02750
DFQEFVNKCLIKNPA

MAP2K2

341

P36507
KALFFPCKAAELVNN

RAPSN

181

Q13702
KFDLNKPVRVCNICF

ANKFY1

1146

Q9P2R3
NLSLNDCFKKVPRDE

FOXI3

196

A8MTJ6
VRQNTKFFFDPVRKC

HELLS

191

Q9NRZ9
CSNFDKEFLNEKPRL

PRKCQ

661

Q04759
ENPCRKFQANIFNKS

MPRIP

6

Q6WCQ1
RKNPRKFVCLNDNID

GNPTAB

1141

Q3T906
SCILQEPKRNLAFFQ

IKBKB

411

O14920
FVKLKQLCVNEPFEE

MTMR10

346

Q9NXD2
SIPCRKRKVLNNFDF

CFAP57

91

Q96MR6
NFLQEKDFCPLDRKR

LNX2

76

Q8N448
CKLTNEDVKQKQPFF

CDKN2AIP

426

Q9NXV6
CPENFIHFNNKLVIK

DDX60

1051

Q8IY21
RTACFIKEQPQAQEK

CCDC190

146

Q86UF4
LIRVLQNFSFKPCKE

CYP3A4

456

P08684
NRTFLKELEKCAENP

MCF2L2

681

Q86YR7
KDLEQIFCQFDPKLE

OGDHL

311

Q9ULD0
LPQKEARFKAFNTCI

OR52A1

231

Q9UKL2
LPQKEARFKAFNTCI

OR52A5

231

Q9H2C5
DFCQLVAQKQKRPTD

NUS1

206

Q96E22
VLKCFVNRNPKIIFD

HACE1

486

Q8IYU2
FCNTFRPVDDKEQRK

PHRF1

796

Q9P1Y6
TDDKKCTNRVFIFNP

KLHL41

456

O60662
KVQCLTDIKNLFFPN

LPIN1

776

Q14693
QKCFVFDRPINDKKL

GBP7

231

Q8N8V2
FIKEFLQPNKCFLEQ

OAS2

351

P29728
KEQARNKCKDFRQFF

PEG3

1026

Q9GZU2
RFISANLPCNKFKNR

PTPRS

1696

Q13332
NVKDALKRFLDNPCR

OR8J2

296

Q8NGG1
FCPNKVEFIKNSLNI

KCNC1

266

P48547
EKFQAECALKFPNRQ

CC2D2A

1271

Q9P2K1
IKPFEEKCNKRFLVN

DOCK11

356

Q5JSL3
VIRALQNFSFKPCKE

CYP3A43

456

Q9HB55
CIQQQDPAFKKRFLD

EFCAB6

631

Q5THR3
RQAIFPKLLCQNAED

AGBL4

351

Q5VU57
DSPEFKEQFKLCINR

CC2D1A

706

Q6P1N0
FENRENLKEKLAPTC

DNAH14

2191

Q0VDD8
PLCAADIQDQLKKRF

MCF2L

66

O15068
QFFKISPDLNIKCER

CDCA2

751

Q69YH5
ANKIVPFFKLCDEQL

DYNC1H1

2066

Q14204
KNKFLIDGFPRNQDN

CMPK1

86

P30085
LVRVLQNFSFKPCKE

CYP3A7

456

P24462
FHEQPELQKKQLCSF

CST2

106

P09228
FHEQPELQKKQLCSF

CST1

106

P01037
QEVKFVKDCPRNLIF

ERCC6L2

81

Q5T890
FHEQPELQKKQLCSF

CST4

106

P01036
FISANLPCNKFKNRL

PTPRF

1656

P10586
FISANLPCNKFKNRL

PTPRD

1661

P23468
QKEKCFEPQLLRFFH

F12

131

P00748
DFDRLQFCPKDTQLK

TATDN1

116

Q6P1N9
ADQNLKFIDPFCKIA

RRP1B

186

Q14684
RLCDNCKKEIPVFNF

TRAFD1

11

O14545
EKNECRKQPFQRAIG

PLCE1

2071

Q9P212
RQKENGPFLRKCFAI

PROM1

146

O43490
KARKFQDSNLAPACF

SETD4

41

Q9NVD3
CNRADFKANQEILPI

ATP1A4

436

Q13733
FRIFQTCDEKKFQLP

CLEC4E

46

Q9ULY5
DKRIPNCKIFFNNSF

TCERG1L

156

Q5VWI1
ISELCKQFRLPFNVK

THEMIS

446

Q8N1K5
DADCFQPAVKRAKLQ

GTF2H1

341

P32780
FRQQLHPAQKNFCKN

ZFP28

241

Q8NHY6
SFCNEIDSRKLPQFK

SETDB2

256

Q96T68
NFCFLKLKNSQVRIP

nan

21

Q6ZQY7
FNQLCQKAPRFKDFQ

USP45

276

Q70EL2
NIQFNDKVNKPFVCQ

ZNF292

1891

O60281
EAQNRPFDSKKACFV

MYH13

26

Q9UKX3
LQNPETCEIFKREKN

TOPAZ1

1066

Q8N9V7
EFCQALQQPDAKVFK

XPOT

936

O43592
CLSQKQFKEQFPDIS

TRIP4

516

Q15650
DEKDNCQLLFNPRQA

THBS2

751

P35442
FKNLFRKFENLTDPC

RAPGEFL1

541

Q9UHV5
NKINCIRPDAFQDLQ

SLIT1

391

O75093
LRNGVKFCKVQNFPE

USP33

596

Q8TEY7
QKAKEFVCFLLQEDP

TRIO

3021

O75962
KPFECQKCRKSFNQL

ZNF181

431

Q2M3W8
LRQQKEAACFKARPN

TPX2

616

Q9ULW0
FKIECLNDIKNLFAP

LPIN2

786

Q92539