Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	activin receptor activity, type I	TGFBR1 ACVR1C	7.68e-05	5	56	2	GO:0016361
GeneOntologyMolecularFunction	activin receptor activity	TGFBR1 ACVR1C	2.75e-04	9	56	2	GO:0017002
GeneOntologyMolecularFunction	activin binding	TGFBR1 ACVR1C	5.01e-04	12	56	2	GO:0048185
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	TGFBR1 FSIP2 C2CD3 POC1A MTOR POC1B RAPGEF2 CFAP69 SPAG6 TCTN1	1.13e-05	670	56	10	GO:0120031
GeneOntologyBiologicalProcess	locomotory behavior	CACNA1C CELSR1 MTOR TMBIM4 CTNS GRM1 AGTPBP1	1.14e-05	284	56	7	GO:0007626
GeneOntologyBiologicalProcess	cell projection assembly	TGFBR1 FSIP2 C2CD3 POC1A MTOR POC1B RAPGEF2 CFAP69 SPAG6 TCTN1	1.37e-05	685	56	10	GO:0030031
GeneOntologyBiologicalProcess	sperm flagellum assembly	FSIP2 POC1B CFAP69 SPAG6	1.61e-05	56	56	4	GO:0120316
GeneOntologyBiologicalProcess	motile cilium assembly	FSIP2 POC1B CFAP69 SPAG6	9.59e-05	88	56	4	GO:0044458
GeneOntologyBiologicalProcess	sperm axoneme assembly	FSIP2 CFAP69 SPAG6	1.07e-04	34	56	3	GO:0007288
GeneOntologyBiologicalProcess	animal organ morphogenesis	TGFBR1 CELSR1 C2CD3 POC1A TMTC3 MTOR CTNNA2 CTNS TEAD1 SPAG6 NIPBL AGTPBP1	1.25e-04	1269	56	12	GO:0009887
GeneOntologyBiologicalProcess	behavior	CACNA1C AMFR CELSR1 MTOR TMBIM4 CTNS GRM1 CFAP69 AGTPBP1 ITPR3	1.26e-04	891	56	10	GO:0007610
GeneOntologyBiologicalProcess	tissue morphogenesis	TGFBR1 CELSR1 C2CD3 TMTC3 MTOR CTNS TEAD1 SPAG6 TCTN1	1.73e-04	750	56	9	GO:0048729
GeneOntologyBiologicalProcess	cilium assembly	FSIP2 C2CD3 POC1A POC1B CFAP69 SPAG6 TCTN1	1.91e-04	444	56	7	GO:0060271
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	CELSR1 C2CD3 TMTC3 MTOR CTNS TEAD1 SPAG6 TCTN1	2.51e-04	619	56	8	GO:0002009
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	FSIP2 POC1B CFAP69 SPAG6 DNAH6	2.61e-04	210	56	5	GO:0060294
GeneOntologyBiologicalProcess	cilium organization	FSIP2 C2CD3 POC1A POC1B CFAP69 SPAG6 TCTN1	2.91e-04	476	56	7	GO:0044782
GeneOntologyBiologicalProcess	cilium-dependent cell motility	FSIP2 POC1B CFAP69 SPAG6 DNAH6	2.91e-04	215	56	5	GO:0060285
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	FSIP2 POC1B CFAP69 SPAG6 DNAH6	2.91e-04	215	56	5	GO:0001539
GeneOntologyBiologicalProcess	central nervous system development	BPTF CELSR1 C2CD3 MTOR CTNNA2 CTNS RAPGEF2 SPAG6 NIPBL TCTN1 AGTPBP1	3.20e-04	1197	56	11	GO:0007417
GeneOntologyBiologicalProcess	adult walking behavior	CACNA1C CTNS AGTPBP1	3.39e-04	50	56	3	GO:0007628
GeneOntologyCellularComponent	axonemal central apparatus	CFAP69 SPAG6	1.01e-04	6	55	2	GO:1990716
GeneOntologyCellularComponent	activin receptor complex	TGFBR1 ACVR1C	1.01e-04	6	55	2	GO:0048179
MousePheno	short sperm flagellum	FSIP2 POC1B CFAP69 SPAG6	5.30e-05	63	46	4	MP:0009239
MousePheno	abnormal cilium morphology	FSIP2 CELSR1 C2CD3 POC1B CFAP69 SPAG6 TCTN1 AGTPBP1	7.37e-05	433	46	8	MP:0013202
Domain	ARM-type_fold	FOCAD MROH8 MTOR MROH2A MMS19 CFAP69 SPAG6 NIPBL AGTPBP1 XPOT	5.77e-08	339	56	10	IPR016024
Domain	ARM-like	MTOR MROH2A MMS19 CFAP69 SPAG6 NIPBL AGTPBP1 XPOT	1.34e-06	270	56	8	IPR011989
Domain	-	MTOR MMS19 CFAP69 SPAG6 NIPBL AGTPBP1 XPOT	4.31e-06	222	56	7	1.25.10.10
Domain	HEAT	MTOR MMS19 SPAG6 NIPBL	2.73e-05	58	56	4	IPR000357
Domain	HEAT_REPEAT	MTOR MROH2A MMS19 NIPBL	5.74e-05	70	56	4	PS50077
Domain	GS	TGFBR1 ACVR1C	1.84e-04	7	56	2	SM00467
Domain	GS_dom	TGFBR1 ACVR1C	1.84e-04	7	56	2	IPR003605
Domain	GS	TGFBR1 ACVR1C	1.84e-04	7	56	2	PS51256
Domain	TGF_beta_GS	TGFBR1 ACVR1C	1.84e-04	7	56	2	PF08515
Domain	Activin_recp	TGFBR1 ACVR1C	3.91e-04	10	56	2	IPR000472
Domain	Activin_recp	TGFBR1 ACVR1C	3.91e-04	10	56	2	PF01064
Domain	GAIN_dom_N	CELSR1 ADGRL4	4.77e-04	11	56	2	IPR032471
Domain	GAIN	CELSR1 ADGRL4	4.77e-04	11	56	2	PF16489
Domain	TGFB_receptor	TGFBR1 ACVR1C	5.72e-04	12	56	2	IPR000333
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH6	7.85e-04	14	56	2	IPR011704
Domain	AAA_5	MDN1 DNAH6	7.85e-04	14	56	2	PF07728
Domain	GPS	CELSR1 ADGRL4	4.66e-03	34	56	2	SM00303
Domain	GPS	CELSR1 ADGRL4	4.93e-03	35	56	2	PF01825
Domain	GPS	CELSR1 ADGRL4	5.21e-03	36	56	2	PS50221
Domain	GPS	CELSR1 ADGRL4	5.50e-03	37	56	2	IPR000203
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD TANC2 CELSR1 C2CD3 MDN1 MTOR UBE3B PCYT2 CHPF RIC1 ITPR3	1.27e-06	1105	56	11	35748872
Pubmed	Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control.	POC1A POC1B	2.55e-06	2	56	2	19109428
Pubmed	Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells.	POC1A POC1B	2.55e-06	2	56	2	18068700
Pubmed	Basal body stability and ciliogenesis requires the conserved component Poc1.	POC1A POC1B	2.55e-06	2	56	2	20008567
Pubmed	Poc1A and Poc1B act together in human cells to ensure centriole integrity.	POC1A POC1B	2.55e-06	2	56	2	23015594
Pubmed	Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.	TMBIM4 ITPR3	2.55e-06	2	56	2	19553469
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	MTOR CTNNA2 NIPBL	3.17e-06	18	56	3	33323119
Pubmed	The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.	AMFR RNF145	7.63e-06	3	56	2	30543180
Pubmed	Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella.	FSIP2 SPAG6	7.63e-06	3	56	2	30137358
Pubmed	Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.	MTOR GRM1	1.52e-05	4	56	2	15254091
Pubmed	Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR.	MTOR GRM1	1.52e-05	4	56	2	18094233
Pubmed	TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.	TGFBR1 MTOR	1.52e-05	4	56	2	22399812
Pubmed	Joubert Syndrome	C2CD3 POC1B TCTN1	2.28e-05	34	56	3	20301500
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	TANC2 CACNA1C RAPGEF2 AGTPBP1 ITPR3 FARP2	2.93e-05	371	56	6	15747579
Pubmed	Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.	FOCAD CELSR1 CTNNA2	3.20e-05	38	56	3	30240734
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	AMFR KRT13 UBE3B MMS19 TCTN1 GOLGA4 XPOT	3.31e-05	564	56	7	21565611
Pubmed	Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice.	GRM1 AGTPBP1	3.80e-05	6	56	2	8230318
Pubmed	ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.	CACNA1C ITPR3	3.80e-05	6	56	2	16352659
Pubmed	Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis.	TGFBR1 ACVR1C	7.09e-05	8	56	2	16845371
Pubmed	Analysis of the sperm flagellar axoneme using gene-modified mice.	CFAP69 SPAG6	7.09e-05	8	56	2	32554934
Pubmed	Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.	TGFBR1 ACVR1C	9.10e-05	9	56	2	14729481
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	AMFR BCAP31 TMTC3 MTOR MMS19 CHPF XPOT ITPR3	1.26e-04	942	56	8	31073040
Pubmed	A genome-wide association study of aging.	COL6A3 ADGRL4	1.39e-04	11	56	2	21782286
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 MDN1 MTOR CTNNA2 RAPGEF2 GRM1 NIPBL GOLGA4	1.47e-04	963	56	8	28671696
Pubmed	Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.	TGFBR1 ACVR1C	1.66e-04	12	56	2	23342175
Pubmed	CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.	POC1A POC1B	2.29e-04	14	56	2	32060285
Pubmed	Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice.	MTOR GRM1	3.01e-04	16	56	2	30466882
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	TMTC3 MTOR MMS19 ITPR3	3.20e-04	202	56	4	33005030
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	BPTF MDN1 HK3 ZFHX4 CBFA2T2 MMS19 AGTPBP1	4.37e-04	857	56	7	25609649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 FSIP2 C2CD3 MDN1 MTOR RAPGEF2 GOLGA4	4.49e-04	861	56	7	36931259
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CACNA1C BPTF KRT13 C2CD3 BCAP31 MDN1 CFAP69 DNAH6 NIPBL	4.61e-04	1442	56	9	35575683
Pubmed	Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.	TCN2 MTOR	5.76e-04	22	56	2	26166573
Pubmed	Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice.	MTOR TCTN1	5.76e-04	22	56	2	29725084
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BPTF MDN1 MTOR NIPBL XPOT ITPR3	6.27e-04	653	56	6	22586326
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ADAMTS10 COL6A3 CBFA2T2 MMS19 TEAD1 RAPGEF2 NIPBL AGTPBP1	6.95e-04	1215	56	8	15146197
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	MTOR XPOT	8.71e-04	27	56	2	23027611
Pubmed	Identification of differentially expressed genes in mouse spermatogenesis.	BCAP31 POC1A	8.71e-04	27	56	2	14581517
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	MTOR MMS19 XPOT	9.72e-04	120	56	3	27320910
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	MTOR CTNNA2 RAPGEF2 GRM1	1.10e-03	281	56	4	28706196
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	TGFBR1 BCAP31 TMTC3 CHPF	1.12e-03	282	56	4	35007762
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	CELSR1 ADGRL4	1.30e-03	33	56	2	25713288
Pubmed	Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.	BPTF TCTN1	1.46e-03	35	56	2	28106071
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	MDN1 DNAH6	1.46e-03	35	56	2	24515614
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BPTF MDN1 CBFA2T2 NIPBL GOLGA4 AGTPBP1	1.50e-03	774	56	6	15302935
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	FOCAD TGFBR1 BCAP31 MDN1 CTNNA2 RNF145 XPOT	1.52e-03	1061	56	7	33845483
Interaction	BSG interactions	TGFBR1 CACNA1C BCAP31 MDN1 MTOR MMS19 CFAP69 XPOT ITPR3 FARP2	4.88e-06	631	53	10	int:BSG
Interaction	TNFSF13B interactions	MDN1 PDSS1 MTOR CFAP69 XPOT	1.51e-05	119	53	5	int:TNFSF13B
GeneFamily	Type 1 receptor serine/threonine kinases	TGFBR1 ACVR1C	1.05e-04	7	41	2	345
GeneFamily	Maestro heat like repeat containing	MROH8 MROH2A	2.72e-04	11	41	2	636
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TANC2 BPTF TMTC3 TMBIM4 NIPBL GOLGA4	1.88e-07	199	56	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	TANC2 BPTF TMTC3 TMBIM4 NIPBL GOLGA4	1.88e-07	199	56	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	TANC2 BPTF TMBIM4 NIPBL GOLGA4	5.00e-06	198	56	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	TANC2 BPTF TMBIM4 NIPBL GOLGA4	5.12e-06	199	56	5	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	droplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 TREML4 HK3 MCMDC2	4.90e-05	160	56	4	a494001b1f6dec33624f98fa3c24bad6988d0425
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C TREML4 HK3 CFAP69	5.14e-05	162	56	4	71d7849108a1b59beff40e46000172c45a2f5439
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HK3 TCN2 PDSS1 CTNNA2	5.39e-05	164	56	4	17d5b8bb7c015cf9f0d6e578a0d212eada39cb93
ToppCell	mild_COVID-19-HSPC\|mild_COVID-19 / disease group, cell group and cell class (v2)	CACNA1C MCMDC2 CFAP69 SPAG6	5.92e-05	168	56	4	90b33962adb77d8326dee403712118398b4d1315
ToppCell	mild_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	CACNA1C MCMDC2 CFAP69 SPAG6	6.20e-05	170	56	4	85c476e0bc496445e868a88849960598d97bdea2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HK3 TCN2 PDSS1 CTNNA2	6.34e-05	171	56	4	87d652afbb375f8ee50e5faecf6085630cd2163c
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOCAD C2CD3 TCN2 ADGRL4	7.25e-05	177	56	4	1921226196b2ab7919d9f843e60d9f4bd9ec9c57
ToppCell	(04)_Pre-ciliated-(3)_72hpi\|(04)_Pre-ciliated / shred by cell type and Timepoint	POC1A CFAP69 SPAG6 DNAH6	9.15e-05	188	56	4	f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 CTNNA2 DNAH6 ITPR3	9.34e-05	189	56	4	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	BPTF CBFA2T2 NIPBL GOLGA4	9.92e-05	192	56	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CELSR1 CFAP69 DNAH6 TCTN1	1.01e-04	193	56	4	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	TEAD1 CFAP69 SPAG6 DNAH6	1.05e-04	195	56	4	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP69 SPAG6 DNAH6 TCTN1	1.05e-04	195	56	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP69 SPAG6 DNAH6 TCTN1	1.05e-04	195	56	4	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	COVID-19-Epithelial-Ciliated_cells\|Epithelial / Condition, Lineage and Cell class	CFAP69 SPAG6 DNAH6 TCTN1	1.07e-04	196	56	4	de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP69 SPAG6 DNAH6 TCTN1	1.07e-04	196	56	4	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP69 SPAG6 DNAH6 TCTN1	1.07e-04	196	56	4	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	CELSR1 TEAD1 CFAP69 DNAH6	1.07e-04	196	56	4	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP69 SPAG6 DNAH6 TCTN1	1.10e-04	197	56	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C COL6A3 TEAD1 CFAP69	1.10e-04	197	56	4	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP69 SPAG6 DNAH6 TCTN1	1.10e-04	197	56	4	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP69 SPAG6 DNAH6 TCTN1	1.10e-04	197	56	4	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP69 SPAG6 DNAH6 TCTN1	1.10e-04	197	56	4	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP69 SPAG6 DNAH6 TCTN1	1.12e-04	198	56	4	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	BPTF TMBIM4 NIPBL GOLGA4	1.14e-04	199	56	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	POC1A CTNNA2 SPAG6 DNAH6	1.14e-04	199	56	4	92778939e9d06599c7d06cfd8f4362b97ed0606b
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	BPTF TMBIM4 NIPBL GOLGA4	1.14e-04	199	56	4	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TGFBR1 CTNNA2 SPAG6 ADGRL4	1.16e-04	200	56	4	6b0235cfbdb70068c43ac71301f4a7b41854929e
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	CFAP69 SPAG6 DNAH6 TCTN1	1.16e-04	200	56	4	3305e14dba12e94da42f0414fdc7a2c8caf0a183
Disease	Intellectual Disability	TANC2 BPTF TCN2 MTOR PCYT2 CTNNA2 TCTN1	1.67e-05	447	54	7	C3714756
Disease	Pachygyria	TMTC3 CTNNA2	3.28e-05	5	54	2	C0266483
Disease	Agyria	TMTC3 CTNNA2	3.28e-05	5	54	2	C1879312
Disease	Lissencephaly	TMTC3 CTNNA2	4.91e-05	6	54	2	C0266463
Disease	Familial aplasia of the vermis	POC1B TCTN1	1.38e-03	30	54	2	C0431399
Disease	Age-related nuclear cataract	FOCAD UBE3B	1.48e-03	31	54	2	HP_0011142

Protein segments in the cluster

Peptide	Gene	Start	Entry
ILTRITQLGIIISLI	ADGRL4	426	Q9HBW9
TNQSLLLELTLILTV	GPR33	271	Q49SQ1
LVQRTIARTIVLQEI	ACVR1C	186	Q8NER5
LNRTLLTTISTQRVL	CELSR1	1286	Q9NYQ6
LTISTLRLTITQLEN	BPTF	901	Q12830
QTTLNILSILVELVS	AGTPBP1	81	Q9UPW5
GSTVNILVTRLILLT	ADAMTS10	281	Q9H324
ILRESSIINQILVIT	RIC1	1286	Q4ADV7
TIVVQLLQSTTRLLE	ITPR3	1496	Q14573
IVGQLDVLTQTVSIL	POC1A	366	Q8NBT0
DVLTQTVSILEQRLT	POC1A	371	Q8NBT0
SSVSTLIQTAILIVQ	MDN1	2361	Q9NU22
ILSLQVLLTTVTSTV	TMBIM4	41	Q9HC24
LEQLQTVLESRSITV	MCMDC2	421	Q4G0Z9
ISVLQTQVSLLKQRL	GOLGA4	221	Q13439
STQLQLVGIRTLTVL	MMS19	456	Q96T76
ILTATIENNRVILEI	KRT13	166	P13646
LRRLVTLISQQATLL	BCAP31	116	P51572
LTRIVTTLVNSIVLE	FSIP2	4981	Q5CZC0
VRTLVLALVNSTVTI	CBFA2T2	141	O43439
TTDLIVQRIITNRLE	PCYT2	341	Q99447
LLTLVGNTTIILVSR	OR2W3	36	Q7Z3T1
LEIQLLTDTTILQVS	NIPBL	1401	Q6KC79
VLTQTVSILEQRLTL	POC1B	441	Q8TC44
SIITLPSVRTLTQIQ	MROH8	186	Q9H579
LLVRVTTGVQITSEI	HK3	551	P52790
IEVLSVIAQQLITIR	DNAH6	1531	Q9C0G6
LVLQVSSLITDLQTI	C2CD3	1951	Q4AC94
IRTIGNIVIVTTLLQ	CACNA1C	1046	Q13936
RLLEPLVTQVTTLVN	CTNNA2	26	P26232
RIGNTTVISILTQVI	PDSS1	221	Q5T2R2
TVISILTQVIEDLVR	PDSS1	226	Q5T2R2
SLVLKQNLTVTDRVI	COL6A3	3031	P12111
LVIRSSAISIINQVI	CTNS	116	O60931
QVIIASILISVQLTL	GRM1	706	Q13255
SILISVQLTLVVTLI	GRM1	711	Q13255
ITEVTTTLQHILIRL	FARP2	716	O94887
RQLRNDILVITTIIA	CFAP69	306	A5D8W1
RLNEVIRTLTQVISV	FOCAD	1306	Q5VW36
LLIVVTIITSQSLRS	OR4C6	41	Q8NH72
TSIQSTIILLIEQIV	MTOR	1046	P42345
TQVLRQILELSVTTN	MROH2A	321	A6NES4
LRTLLLDVVPTIQQT	SPAG6	46	O75602
IVTVRTSLQEITKLL	TANC2	576	Q9HCD6
LVQRTIARTIVLQES	TGFBR1	196	P36897
TQEIISVTLQVLSLL	TCN2	326	P20062
VLQDLQLTRSVEITT	AMFR	476	Q9UKV5
RQRLLVAVLTSQTTL	CHPF	116	Q8IZ52
ITTNIITLIVKLTRD	CLEC2B	16	Q92478
ISLLQLSTVEVATQL	RAPGEF2	711	Q9Y4G8
IEQLSTVLNLPTRVI	ZFHX4	2211	Q86UP3
QVLTAASVLRIQTVI	ZBTB45	101	Q96K62
ENIITVLRNISLVVS	TREML4	116	Q6UXN2
VQSIVIQSLNKTLTR	TCTN1	286	Q2MV58
LTTLTQIRLQILTGL	UBE3B	471	Q7Z3V4
LTTVQQQLIRETLIS	XPOT	71	O43592
TILLVVTNRDTQETL	TEAD1	386	P28347
TLLLVVIRVQVIQSQ	TMTC3	246	Q6ZXV5
LIIISSSILTSLQVL	RNF145	411	Q96MT1