Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	HGFAC MMP28 ADAM18 PRSS56 CAPN6 KLK12 TMPRSS4 TMPRSS12 ADAMTS8 ADAM11 ADAM32 ASTL PIK3IP1 TMPRSS3 USP48 CTSZ	2.89e-06	430	186	16	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	HGFAC RELN MMP28 ADAM18 PRSS56 CAPN6 KLK12 TMPRSS4 TMPRSS12 ADAMTS8 ADAM11 ADAM32 ASTL PIK3IP1 TGM2 TMPRSS3 USP48 MYRF CTSZ ALG13	3.28e-06	654	186	20	GO:0008233
GeneOntologyBiologicalProcess	epithelium development	KRT72 KRT3 FLNA TBX4 GCM2 GATA2 ETV5 IRF6 KEAP1 CUL7 NSUN2 TYMS TGM2 FASN IGF1R OVOL1 THRA AKAP9 EGF F11R BSG RPTOR SEC24B SAFB2 ROCK1 ATF4 POFUT1 CSMD1 AJUBA USH2A TMEM100 CTSZ SEMA3E	5.85e-07	1469	182	33	GO:0060429
GeneOntologyBiologicalProcess	epithelial cell differentiation	KRT72 KRT3 FLNA GCM2 GATA2 IRF6 KEAP1 CUL7 TYMS FASN OVOL1 THRA AKAP9 F11R RPTOR SEC24B SAFB2 ROCK1 ATF4 USH2A TMEM100	2.92e-05	870	182	21	GO:0030855
GeneOntologyBiologicalProcess	blood vessel morphogenesis	HSPG2 FLNA AAMP STAB2 TBX4 GATA2 CUL7 PTGER4 NRP2 TGM2 EGF BSG PIK3CB SEC24B ROCK1 POFUT1 PLCG1 CX3CL1 TMEM100 SEMA3E	3.76e-05	817	182	20	GO:0048514
GeneOntologyCellularComponent	extracellular matrix	HSPG2 RELN MXRA5 ZAN MMP28 ADAMTS8 ADAM11 SSPOP F13A1 TGM2 FBN1 FBN2 HMCN1 OTOGL LRRTM4 USH2A FBN3 CTSZ	2.42e-05	656	186	18	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	HSPG2 RELN MXRA5 ZAN MMP28 ADAMTS8 ADAM11 SSPOP F13A1 TGM2 FBN1 FBN2 HMCN1 OTOGL LRRTM4 USH2A FBN3 CTSZ	2.52e-05	658	186	18	GO:0030312
GeneOntologyCellularComponent	neuronal cell body	BOC FLNA RELN ITGA8 ADAM11 HCN2 SEZ6L2 PTGER4 STRN IGF1R AKAP9 RPTOR TMPRSS3 AGFG1 CACNA1G IGSF9B USH2A CX3CL1 TMEM100	1.73e-04	835	186	19	GO:0043025
GeneOntologyCellularComponent	microfibril	FBN1 FBN2 FBN3	1.86e-04	13	186	3	GO:0001527
GeneOntologyCellularComponent	collagen-containing extracellular matrix	HSPG2 RELN MXRA5 MMP28 ADAMTS8 ADAM11 SSPOP F13A1 TGM2 FBN1 FBN2 HMCN1 USH2A CTSZ	2.94e-04	530	186	14	GO:0062023
GeneOntologyCellularComponent	cell body	BOC FLNA RELN ITGA8 ADAM11 HCN2 SEZ6L2 PTGER4 STRN IGF1R AKAP9 RPTOR TMPRSS3 AGFG1 CACNA1G IGSF9B USH2A CX3CL1 TMEM100	6.48e-04	929	186	19	GO:0044297
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	TUT4 TRIM25 EXD1 NSUN2 DHX9 AGO4 RPTOR ROCK1 AJUBA	7.06e-04	269	186	9	GO:0036464
Domain	EGF_1	SELE HGFAC HSPG2 RELN STAB2 ZAN ADAM18 ADAM11 ADAM32 CUBN SSPOP FBN1 FBN2 EGF HMCN1 USH2A FBN3	5.87e-10	255	183	17	PS00022
Domain	EGF_3	SELE HGFAC HSPG2 RELN STAB2 ZAN ADAM18 ADAM11 ADAM32 CUBN SSPOP FBN1 FBN2 EGF HMCN1 FBN3	1.42e-09	235	183	16	PS50026
Domain	EGF_2	SELE HGFAC HSPG2 RELN STAB2 ZAN ADAM18 ADAM11 ADAM32 CUBN SSPOP FBN1 FBN2 EGF HMCN1 FBN3	7.98e-09	265	183	16	PS01186
Domain	EGF-like_dom	SELE HGFAC HSPG2 RELN STAB2 ZAN ADAM18 ADAM11 ADAM32 CUBN FBN1 FBN2 EGF HMCN1 FBN3	2.46e-08	249	183	15	IPR000742
Domain	EGF-like_CS	SELE HGFAC HSPG2 RELN STAB2 ZAN ADAM18 ADAM11 ADAM32 CUBN FBN1 FBN2 EGF HMCN1 FBN3	4.59e-08	261	183	15	IPR013032
Domain	EGF	SELE HGFAC HSPG2 RELN STAB2 ZAN ADAM11 ADAM32 CUBN FBN1 FBN2 EGF HMCN1 FBN3	8.40e-08	235	183	14	SM00181
Domain	FBN	FBN1 FBN2 FBN3	9.25e-07	3	183	3	IPR011398
Domain	EGF	SELE HGFAC HSPG2 STAB2 ZAN CUBN EGF HMCN1 FBN3	4.21e-06	126	183	9	PF00008
Domain	CUB	DCBLD1 CUBN CSMD3 SEZ6L2 NRP2 CSMD1	8.03e-06	49	183	6	PF00431
Domain	CUB	DCBLD1 CUBN CSMD3 SEZ6L2 NRP2 CSMD1	9.06e-06	50	183	6	SM00042
Domain	-	DCBLD1 CUBN CSMD3 SEZ6L2 NRP2 CSMD1	1.14e-05	52	183	6	2.60.120.290
Domain	CUB	DCBLD1 CUBN CSMD3 SEZ6L2 NRP2 CSMD1	1.28e-05	53	183	6	PS01180
Domain	CUB_dom	DCBLD1 CUBN CSMD3 SEZ6L2 NRP2 CSMD1	1.95e-05	57	183	6	IPR000859
Domain	IGc2	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG IGSF9B IGSF1 LILRB5	2.11e-05	235	183	11	SM00408
Domain	Ig_sub2	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG IGSF9B IGSF1 LILRB5	2.11e-05	235	183	11	IPR003598
Domain	Growth_fac_rcpt_	HSPG2 STAB2 CUBN IGF1R FBN1 FBN2 EGF HMCN1 FBN3	2.37e-05	156	183	9	IPR009030
Domain	EGF_CA	HSPG2 STAB2 CUBN FBN1 FBN2 EGF HMCN1 FBN3	2.71e-05	122	183	8	SM00179
Domain	-	BOC HSPG2 FLNA MXRA5 RBPJL OBSCN HEPACAM2 F13A1 TGM2 IGF1R F11R HMCN1 BSG FCRLB IGSF9B IGSF1 USH2A LILRB5 SEMA3E	2.89e-05	663	183	19	2.60.40.10
Domain	EGF-like_Ca-bd_dom	HSPG2 STAB2 CUBN FBN1 FBN2 EGF HMCN1 FBN3	3.05e-05	124	183	8	IPR001881
Domain	TB	FBN1 FBN2 FBN3	3.15e-05	7	183	3	PF00683
Domain	-	FBN1 FBN2 FBN3	5.00e-05	8	183	3	3.90.290.10
Domain	Ig-like_fold	BOC HSPG2 FLNA MXRA5 RBPJL OBSCN HEPACAM2 F13A1 TGM2 IGF1R F11R HMCN1 BSG FCRLB IGSF9B IGSF1 USH2A LILRB5 SEMA3E	6.73e-05	706	183	19	IPR013783
Domain	TB_dom	FBN1 FBN2 FBN3	7.44e-05	9	183	3	IPR017878
Domain	TB	FBN1 FBN2 FBN3	7.44e-05	9	183	3	PS51364
Domain	Ig_I-set	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG IGSF9B	1.10e-04	190	183	9	IPR013098
Domain	I-set	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG IGSF9B	1.10e-04	190	183	9	PF07679
Domain	ig	BOC HSPG2 OBSCN F11R HMCN1 BSG IGSF1 LILRB5 SEMA3E	1.10e-04	190	183	9	PF00047
Domain	Immunoglobulin	BOC HSPG2 OBSCN F11R HMCN1 BSG IGSF1 LILRB5 SEMA3E	1.10e-04	190	183	9	IPR013151
Domain	cEGF	FBN1 FBN2 HMCN1 FBN3	1.13e-04	26	183	4	PF12662
Domain	cEGF	FBN1 FBN2 HMCN1 FBN3	1.13e-04	26	183	4	IPR026823
Domain	ADAM_Cys-rich	ADAM18 ADAMTS8 ADAM11 ADAM32	1.31e-04	27	183	4	IPR006586
Domain	ACR	ADAM18 ADAMTS8 ADAM11 ADAM32	1.31e-04	27	183	4	SM00608
Domain	-	MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL	1.44e-04	81	183	6	3.40.390.10
Domain	MetalloPept_cat_dom	MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL	1.44e-04	81	183	6	IPR024079
Domain	GFP-like	STAB2 EGF HMCN1	1.44e-04	11	183	3	IPR023413
Domain	-	STAB2 EGF HMCN1	1.44e-04	11	183	3	2.40.155.10
Domain	EGF_CA	CUBN FBN1 FBN2 EGF HMCN1 FBN3	2.00e-04	86	183	6	PF07645
Domain	TRYPSIN_SER	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	2.57e-04	90	183	6	IPR033116
Domain	IG	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG FCRLB IGSF9B IGSF1 LILRB5 SEMA3E	2.71e-04	421	183	13	SM00409
Domain	Ig_sub	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG FCRLB IGSF9B IGSF1 LILRB5 SEMA3E	2.71e-04	421	183	13	IPR003599
Domain	Cul7	CUL7 HERC2	2.85e-04	3	183	2	PF11515
Domain	CPH_domain	CUL7 HERC2	2.85e-04	3	183	2	IPR021097
Domain	EGF_extracell	RELN STAB2 ADAM18 ADAM11 ADAM32	3.02e-04	60	183	5	IPR013111
Domain	EGF_2	RELN STAB2 ADAM18 ADAM11 ADAM32	3.02e-04	60	183	5	PF07974
Domain	Galactose-bd-like	DCBLD1 CUL7 SSPOP NRP2 NDUFAF1 HERC2	3.25e-04	94	183	6	IPR008979
Domain	EGF_Ca-bd_CS	CUBN FBN1 FBN2 EGF HMCN1 FBN3	3.85e-04	97	183	6	IPR018097
Domain	EGF_CA	CUBN FBN1 FBN2 EGF HMCN1 FBN3	4.30e-04	99	183	6	PS01187
Domain	ASX_HYDROXYL	CUBN FBN1 FBN2 EGF HMCN1 FBN3	4.53e-04	100	183	6	PS00010
Domain	Disintegrin_CS	ADAM18 ADAM11 ADAM32	4.72e-04	16	183	3	IPR018358
Domain	TRYPSIN_HIS	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	5.31e-04	103	183	6	IPR018114
Domain	Pep_M12B_propep	ADAM18 ADAMTS8 ADAM11 ADAM32	5.61e-04	39	183	4	PF01562
Domain	Peptidase_M12B_N	ADAM18 ADAMTS8 ADAM11 ADAM32	5.61e-04	39	183	4	IPR002870
Domain	EGF-type_Asp/Asn_hydroxyl_site	CUBN FBN1 FBN2 EGF HMCN1 FBN3	6.18e-04	106	183	6	IPR000152
Domain	TRYPSIN_SER	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	6.18e-04	106	183	6	PS00135
Domain	DISINTEGRIN_1	ADAM18 ADAMTS8 ADAM11 ADAM32	6.19e-04	40	183	4	PS00427
Domain	Reprolysin	ADAM18 ADAMTS8 ADAM11 ADAM32	6.19e-04	40	183	4	PF01421
Domain	ADAM_MEPRO	ADAM18 ADAMTS8 ADAM11 ADAM32	6.19e-04	40	183	4	PS50215
Domain	DISINTEGRIN_2	ADAM18 ADAMTS8 ADAM11 ADAM32	6.19e-04	40	183	4	PS50214
Domain	Peptidase_M12B	ADAM18 ADAMTS8 ADAM11 ADAM32	6.19e-04	40	183	4	IPR001590
Domain	TRYPSIN_HIS	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	6.50e-04	107	183	6	PS00134
Domain	ADAM_CR	ADAM18 ADAM11 ADAM32	6.78e-04	18	183	3	PF08516
Domain	Disintegrin_dom	ADAM18 ADAMTS8 ADAM11 ADAM32	6.80e-04	41	183	4	IPR001762
Domain	-	DCBLD1 CUL7 SSPOP NRP2 HERC2	7.49e-04	73	183	5	2.60.120.260
Domain	Ig_2	HSPG2 FCRLB IGSF9B IGSF1 LILRB5	7.49e-04	73	183	5	PF13895
Domain	IGv	HSPG2 OBSCN F11R HMCN1 IGSF9B	8.48e-04	75	183	5	SM00406
Domain	Peptidase_S1A	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	8.66e-04	113	183	6	IPR001314
Domain	-	ADAM18 ADAM11 ADAM32	9.33e-04	20	183	3	4.10.70.10
Domain	-	RELN NEU2	9.36e-04	5	183	2	2.120.10.10
Domain	TRYPSIN_DOM	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	9.49e-04	115	183	6	PS50240
Domain	Ldl_recept_a	HSPG2 TMPRSS4 SSPOP TMPRSS3	9.71e-04	45	183	4	PF00057
Domain	Tryp_SPc	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	1.04e-03	117	183	6	SM00020
Domain	-	HSPG2 TMPRSS4 SSPOP TMPRSS3	1.06e-03	46	183	4	4.10.400.10
Domain	Disintegrin	ADAM18 ADAM11 ADAM32	1.08e-03	21	183	3	PF00200
Domain	FA58C	DCBLD1 SSPOP NRP2	1.08e-03	21	183	3	SM00231
Domain	FA58C_3	DCBLD1 SSPOP NRP2	1.08e-03	21	183	3	PS50022
Domain	DISIN	ADAM18 ADAM11 ADAM32	1.08e-03	21	183	3	SM00050
Domain	FA58C_1	DCBLD1 SSPOP NRP2	1.08e-03	21	183	3	PS01285
Domain	FA58C_2	DCBLD1 SSPOP NRP2	1.08e-03	21	183	3	PS01286
Domain	IG_LIKE	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG FCRLB IGSF9B IGSF1 LILRB5 SEMA3E	1.14e-03	491	183	13	PS50835
Domain	Trypsin_dom	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	1.23e-03	121	183	6	IPR001254
Domain	Trypsin	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	1.23e-03	121	183	6	PF00089
Domain	LDLRA_1	HSPG2 TMPRSS4 SSPOP TMPRSS3	1.24e-03	48	183	4	PS01209
Domain	LDrepeatLR_classA_rpt	HSPG2 TMPRSS4 SSPOP TMPRSS3	1.34e-03	49	183	4	IPR002172
Domain	LDLa	HSPG2 TMPRSS4 SSPOP TMPRSS3	1.34e-03	49	183	4	SM00192
Domain	LDLRA_2	HSPG2 TMPRSS4 SSPOP TMPRSS3	1.34e-03	49	183	4	PS50068
Domain	Peptidase_S1_PA	HGFAC PRSS56 KLK12 TMPRSS4 TMPRSS12 TMPRSS3	1.34e-03	123	183	6	IPR009003
Domain	Ig-like_dom	BOC HSPG2 MXRA5 OBSCN HEPACAM2 F11R HMCN1 BSG FCRLB IGSF9B IGSF1 LILRB5 SEMA3E	1.41e-03	503	183	13	IPR007110
Domain	F5_F8_type_C	DCBLD1 SSPOP NRP2	1.61e-03	24	183	3	PF00754
Domain	FA58C	DCBLD1 SSPOP NRP2	1.61e-03	24	183	3	IPR000421
Domain	Sushi	SELE CSMD3 SEZ6L2 CSMD1	1.67e-03	52	183	4	PF00084
Domain	CCP	SELE CSMD3 SEZ6L2 CSMD1	1.92e-03	54	183	4	SM00032
Domain	APC_su10/DOC_dom	CUL7 HERC2	1.94e-03	7	183	2	IPR004939
Domain	DOC	CUL7 HERC2	1.94e-03	7	183	2	PS51284
Domain	SRCR_2	TMPRSS4 TMPRSS3	1.94e-03	7	183	2	PF15494
Domain	ANAPC10	CUL7 HERC2	1.94e-03	7	183	2	PF03256
Domain	APC10	CUL7 HERC2	1.94e-03	7	183	2	SM01337
Domain	SUSHI	SELE CSMD3 SEZ6L2 CSMD1	2.20e-03	56	183	4	PS50923
Domain	Sushi_SCR_CCP_dom	SELE CSMD3 SEZ6L2 CSMD1	2.35e-03	57	183	4	IPR000436
Domain	EGF_LAM_2	HSPG2 STAB2 USH2A	3.09e-03	30	183	3	PS50027
Domain	EGF_LAM_1	HSPG2 STAB2 USH2A	3.09e-03	30	183	3	PS01248
Pathway	WP_HEAD_AND_NECK_SQUAMOUS_CELL_CARCINOMA	IRF6 KEAP1 CSMD3 IGF1R PIK3CB RPTOR AJUBA	1.22e-05	74	148	7	M39857
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	BOC MMP28 ADAM18 SLC22A15 KLK12 TMPRSS4 HEPACAM2 ACSF2 ADAM32 ST6GALNAC6 SEZ6L2 HEPH F11R DGAT2 BSG LRRTM4 TMPRSS3 IGSF9B FAR1 CSMD1 KAT14 GPN3	1.99e-08	985	187	22	12975309
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 FLNA TPRA1 RPS6KA2 TMC6 OBSCN GATA2 SPATA20 AHDC1 FASN IGF1R OVOL1 SETD5 RPTOR DISP2 IRS2 POFUT1 PLCG1 LRBA HERC2 MYRF ARHGAP21 CTSZ	3.36e-08	1105	187	23	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUT4 PHLDA1 ACTR5 PATZ1 PRSS56 GAS7 KEAP1 CUL7 RSBN1 INTS6 FBN2 THRA SETD5 RPTOR BRD7 IRS2 FAR1 CSMD1 ADGRL2 KAT14 INO80B ALG13	1.74e-07	1116	187	22	31753913
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	HSPG2 RELN SSPOP F13A1 TGM2 FBN1 FBN2 HMCN1 CTSZ	4.95e-07	175	187	9	28071719
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2 FBN3	6.09e-07	4	187	3	25034023
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNA TRIM25 POLA1 ACO2 DHX38 MCCC2 NSUN2 ERLIN1 DHX9 TBCB TGM2 FASN SAFB LLGL1 BAZ1A RPTOR SEC24B SAFB2 ACAA2 EXOC1 PLCG1 HERC2 FAR1	1.17e-06	1353	187	23	29467282
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	HSPG2 FBN1 FBN2	1.52e-06	5	187	3	23493297
Pubmed	TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation.	TET2 EGLN3 TET3	1.52e-06	5	187	3	32963106
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	HSPG2 FLNA PHLDA1 ACO2 POR NIPSNAP3A MCCC2 ACSF2 F13A1 NRP2 RSBN1 TGM2 FASN NEU2 FBN1 AKAP9 NDUFAF1 CLCN5 BSG SEC24B ACAA2 POFUT1 CTSZ	3.76e-06	1451	187	23	30550785
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	HSPG2 NRIP1 ERCC5 ACO2 GAS7 SYBU ST6GALNAC6 SSPOP AHDC1 TBCB CACNA1G KLHL12 AJUBA ALG13	6.00e-06	608	187	14	16713569
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	BOC HGFAC ADAM18 KLK12 TMPRSS4 HEPACAM2 ADAM32 SEZ6L2 DGAT2 LRRTM4 TMPRSS3 FAR1	8.23e-06	460	187	12	20562862
Pubmed	Downregulation of ten-eleven translocation-2 triggers epithelial differentiation during organogenesis.	TET2 AQP5 TET3	8.40e-06	8	187	3	35569195
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	FLNA TRIM25 ACO2 MCCC2 NSUN2 DHX9 DNAH1 TGM2 FASN SAFB AKAP9 LPXN CACNA1G LRBA SPAG17 ALG13	8.47e-06	807	187	16	30575818
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	FLNA TRIM25 KEAP1 GPRIN1 FASN LLGL1 F11R BSG SVIL SEC24B AGFG1 ADGRL2 ARHGAP21	1.31e-05	565	187	13	25468996
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FLNA TRIM25 DHX38 KEAP1 GPRIN1 NSUN2 TBCB FASN SAFB BAZ1A SEC24B AGFG1 SAFB2 IRS2 PLCG1 LRBA ARHGAP21	1.33e-05	934	187	17	33916271
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 FLNA NRIP1 MCCC2 KEAP1 FASN IRS2 LRBA FAR1 KAT14 ARHGAP21	1.82e-05	418	187	11	34709266
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NRIP1 TPRA1 TUT4 RPS6KA2 TMC6 OBSCN MCCC2 FOXJ3 SSPOP AHDC1 DNAH1 INTS6 IGF1R THRA SETD5 RPTOR WDR45B IGSF9B PLCG1 LRBA CSMD1 TET3	1.84e-05	1489	187	22	28611215
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	FLNA TRIM25 NSUN2 DHX9 FASN SAFB SVIL SEC24B ARHGAP21	1.92e-05	274	187	9	34244482
Pubmed	Maternal synchronization of gestational length and lung maturation.	ITGA8 ETV5 AQP5 FASN	2.27e-05	31	187	4	22096492
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	FLNA DHX38 ERLIN1 TGM2 FBN2 AKAP9 SVIL	2.30e-05	156	187	7	29961565
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FLNA ERCC5 STARD8 DHX38 OBSCN SLFN12 CUBN FOXJ3 F13A1 ERLIN1 PTCD1 SETD5 BAZ1A SAFB2 N4BP2L2 ROCK1 PLCG1 ARHGAP21	2.49e-05	1084	187	18	11544199
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	HSPG2 ADAMTS8 ADAM11 SSPOP HMCN1	2.51e-05	64	187	5	22261194
Pubmed	Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.	ETV5 IGF1R PIK3CB RPTOR	2.59e-05	32	187	4	34193412
Pubmed	Investigation of the Relationship Between Radiation Dose and Gene Mutations and Fusions in Post-Chernobyl Thyroid Cancer.	POR STRN	2.88e-05	2	187	2	29165687
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	2.88e-05	2	187	2	30044367
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	2.88e-05	2	187	2	15131124
Pubmed	Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion.	TGM2 EGF	2.88e-05	2	187	2	19403524
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	2.88e-05	2	187	2	20404337
Pubmed	Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells.	ITGA8 FBN1	2.88e-05	2	187	2	25482639
Pubmed	Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.	TET2 TET3	2.88e-05	2	187	2	27852070
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	2.88e-05	2	187	2	8791520
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	2.88e-05	2	187	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	2.88e-05	2	187	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	2.88e-05	2	187	2	18006876
Pubmed	Seasonal effects of the UCP3 and the RPTOR gene polymorphisms on obesity traits in Japanese adults.	RPTOR UCP3	2.88e-05	2	187	2	25533680
Pubmed	Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons.	TET2 TET3	2.88e-05	2	187	2	32367481
Pubmed	A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal.	SLC5A1 IGF1R	2.88e-05	2	187	2	23531874
Pubmed	Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts.	PTGER4 AQP2	2.88e-05	2	187	2	26100911
Pubmed	Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum.	SLC2A5 SLC5A1	2.88e-05	2	187	2	36746764
Pubmed	Expression of DGAT2 in white adipose tissue is regulated by central leptin action.	DGAT2 IRS2	2.88e-05	2	187	2	15550388
Pubmed	LRBA is essential for urinary concentration and body water homeostasis.	AQP2 LRBA	2.88e-05	2	187	2	35862451
Pubmed	Microfibrils at basement membrane zones interact with perlecan via fibrillin-1.	HSPG2 FBN1	2.88e-05	2	187	2	15657057
Pubmed	Transglutaminases in mineralized tissues.	F13A1 TGM2	2.88e-05	2	187	2	16368540
Pubmed	The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene.	POR KAT14	2.88e-05	2	187	2	20808945
Pubmed	Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma.	SELE PLCG1	2.88e-05	2	187	2	12960351
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	2.88e-05	2	187	2	12524050
Pubmed	SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.	SAFB SAFB2	2.88e-05	2	187	2	19901029
Pubmed	Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.	IGF1R IRS2	2.88e-05	2	187	2	10829031
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	2.88e-05	2	187	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	2.88e-05	2	187	2	35419902
Pubmed	TET proteins regulate Drosha expression and impact microRNAs in iNKT cells.	TET2 TET3	2.88e-05	2	187	2	39364402
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	2.88e-05	2	187	2	10504303
Pubmed	Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice.	CLCN3 CLCN5	2.88e-05	2	187	2	38666049
Pubmed	Factor XIIIA mobilizes transglutaminase 2 to induce chondrocyte hypertrophic differentiation.	F13A1 TGM2	2.88e-05	2	187	2	18544639
Pubmed	Low SAFB levels are associated with worse outcome in breast cancer patients.	SAFB SAFB2	2.88e-05	2	187	2	19137425
Pubmed	cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus.	AQP2 PLCG1	2.88e-05	2	187	2	10191086
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	2.88e-05	2	187	2	25524144
Pubmed	TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.	TET2 CSMD1	2.88e-05	2	187	2	25695618
Pubmed	Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.	TET2 TET3	2.88e-05	2	187	2	27729528
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	2.88e-05	2	187	2	16407178
Pubmed	Is HSPG2 a modifier gene for Marfan syndrome?	HSPG2 FBN1	2.88e-05	2	187	2	32514132
Pubmed	Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.	SAFB SAFB2	2.88e-05	2	187	2	26273616
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	2.88e-05	2	187	2	10359653
Pubmed	Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.	SAFB SAFB2	2.88e-05	2	187	2	26092125
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	2.88e-05	2	187	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	2.88e-05	2	187	2	21851253
Pubmed	A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer.	TMPRSS4 TMPRSS3	2.88e-05	2	187	2	10825129
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	2.88e-05	2	187	2	21440062
Pubmed	Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?	SAFB SAFB2	2.88e-05	2	187	2	14587024
Pubmed	TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression.	TET2 GATA2	2.88e-05	2	187	2	37794021
Pubmed	The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis.	EGF PLCG1	2.88e-05	2	187	2	20621058
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	2.88e-05	2	187	2	8307578
Pubmed	Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.	IGF1R IRS2	2.88e-05	2	187	2	19487308
Pubmed	Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis.	TET2 TET3	2.88e-05	2	187	2	38179947
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	2.88e-05	2	187	2	24833718
Pubmed	Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.	TET2 TET3	2.88e-05	2	187	2	32126143
Pubmed	Key role of PLC-gamma in EGF protection of epithelial barrier against iNOS upregulation and F-actin nitration and disassembly.	EGF PLCG1	2.88e-05	2	187	2	12788694
Pubmed	Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells.	TGM2 EGF	2.88e-05	2	187	2	15272014
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	2.88e-05	2	187	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	2.88e-05	2	187	2	20529844
Pubmed	IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production.	IRS2 PLCG1	2.88e-05	2	187	2	9535722
Pubmed	Reactivity of the N-terminal region of fibronectin protein to transglutaminase 2 and factor XIIIA.	F13A1 TGM2	2.88e-05	2	187	2	21757696
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	2.88e-05	2	187	2	23133647
Pubmed	Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration.	EGF PLCG1	2.88e-05	2	187	2	20674545
Pubmed	Impaired clot retraction in factor XIII A subunit-deficient mice.	F13A1 TGM2	2.88e-05	2	187	2	19996413
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	2.88e-05	2	187	2	1852206
Pubmed	Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.	SAFB SAFB2	2.88e-05	2	187	2	22566185
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	2.88e-05	2	187	2	12429739
Pubmed	TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.	TRIM25 KEAP1	2.88e-05	2	187	2	37188737
Pubmed	Acute loss of TET function results in aggressive myeloid cancer in mice.	TET2 TET3	2.88e-05	2	187	2	26607761
Pubmed	Fractalkine depresses cardiomyocyte contractility.	PTGER4 CX3CL1	2.88e-05	2	187	2	23936109
Pubmed	Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc.	HSPG2 FBN1	2.88e-05	2	187	2	23104139
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	2.88e-05	2	187	2	15221638
Pubmed	GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts.	GATA2 AQP2	2.88e-05	2	187	2	24636993
Pubmed	TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.	TET2 TET3	2.88e-05	2	187	2	37414790
Pubmed	TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.	TET2 TET3	2.88e-05	2	187	2	31120187
Pubmed	No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.	SAFB SAFB2	2.88e-05	2	187	2	19077293
Pubmed	Distinct roles for TET family proteins in regulating human erythropoiesis.	TET2 TET3	2.88e-05	2	187	2	28167661
Pubmed	Role of transglutaminases in cuff-induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice.	F13A1 TGM2	2.88e-05	2	187	2	20810110
Pubmed	The Fbn1 gene variant governs passive ascending aortic mechanics in the mgΔlpn mouse model of Marfan syndrome when superimposed to perlecan haploinsufficiency.	HSPG2 FBN1	2.88e-05	2	187	2	38545339
Cytoband	11q25	ADAMTS8 ACAD8 IGSF9B	1.61e-04	26	187	3	11q25
GeneFamily	Immunoglobulin like domain containing	BOC HSPG2 MXRA5 HEPACAM2 F11R BSG FCRLB IGSF9B IGSF1 SEMA3E	1.00e-06	193	126	10	594
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	BOC HSPG2 MXRA5 OBSCN HEPACAM2 HMCN1 BSG IGSF9B	1.71e-05	161	126	8	593
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELE CSMD3 SEZ6L2 CSMD1	6.68e-04	57	126	4	1179
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM18 ADAM11 ADAM32	8.55e-04	27	126	3	47
GeneFamily	Proteases, serine	PRSS56 TMPRSS4 TMPRSS12 TMPRSS3	9.75e-04	63	126	4	738
GeneFamily	Transglutaminases	F13A1 TGM2	1.68e-03	9	126	2	773
GeneFamily	Chloride voltage-gated channels	CLCN3 CLCN5	2.09e-03	10	126	2	302
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	GRB14 ROCK1 IRS2 PLCG1 ARHGAP21 PHLPP2	3.23e-03	206	126	6	682
Coexpression	NABA_MATRISOME	HGFAC HSPG2 EGLN3 RELN MXRA5 MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL SSPOP F13A1 PIK3IP1 IFNW1 TGM2 FBN1 FBN2 EGF HMCN1 USH2A CX3CL1 FBN3 CTSZ SEMA3E	8.74e-08	1026	187	25	M5889
Coexpression	NABA_MATRISOME	HGFAC HSPG2 EGLN3 RELN MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL SSPOP F13A1 PIK3IP1 IFNW1 TGM2 FBN1 FBN2 EGF HMCN1 OTOGL CX3CL1 CTSZ SEMA3E	9.34e-07	1008	187	23	MM17056
Coexpression	NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON	TBX4 TRIM25 ERN1 TMC6 SPATA20 ACSF2 FASN ABCA5 RPTOR WDR45B CACNA1G TMEM100	5.48e-06	334	187	12	M15936
Coexpression	NABA_ECM_REGULATORS	EGLN3 MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL F13A1 TGM2 CTSZ	8.75e-06	238	187	10	M3468
Coexpression	NABA_ECM_REGULATORS	EGLN3 MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL F13A1 TGM2 CTSZ	1.01e-05	242	187	10	MM17062
Coexpression	GSE23502_WT_VS_HDC_KO_MYELOID_DERIVED_SUPPRESSOR_CELL_BM_DN	SLFN12 GAS7 PTGER4 NRP2 PIK3IP1 TGM2 LPXN ADGRL2 CTSZ	1.44e-05	200	187	9	M8089
Coexpression	GSE22935_UNSTIM_VS_12H_MBOVIS_BCG_STIM_MYD88_KO_MACROPHAGE_UP	KRT72 PHLDA1 GAS7 CAMK1G ADAMTS8 ADAM11 PTGER4 AHDC1 IGF1R	1.44e-05	200	187	9	M7758
Coexpression	PDGF_UP.V1_DN	MXRA5 CUBN FBN2 EGF ARSL ARSF LILRB5	5.65e-05	136	187	7	M2832
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	NRIP1 TUT4 KEAP1 FOXJ3 AHDC1 RSBN1 STRN AKAP9 BAZ1A ADGRL2	6.31e-05	300	187	10	M8702
Coexpression	NABA_MATRISOME_ASSOCIATED	HGFAC EGLN3 MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL F13A1 PIK3IP1 IFNW1 TGM2 EGF CX3CL1 CTSZ SEMA3E	8.44e-05	738	187	16	MM17058
Coexpression	NABA_ECM_GLYCOPROTEINS	RELN MXRA5 SSPOP FBN1 FBN2 HMCN1 USH2A FBN3	8.63e-05	196	187	8	M3008
Coexpression	GSE17721_CTRL_VS_PAM3CSK4_0.5H_BMDC_UP	SLFN12 NSUN2 ERLIN1 NEU2 NDUFAF1 DGAT2 BSG FAR1	9.93e-05	200	187	8	M3728
Coexpression	GSE17721_CTRL_VS_CPG_6H_BMDC_DN	DHX38 CAPN6 NIPSNAP3A HCN2 F11R DGAT2 AGFG1 HERC2	9.93e-05	200	187	8	M3765
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_UP	ADAM18 ETV5 TMPRSS4 CAMK1G DHX9 ACAD8 SETD5 LILRB5	9.93e-05	200	187	8	M5003
Coexpression	HALLMARK_ESTROGEN_RESPONSE_EARLY	NRIP1 RPS6KA2 SYBU TGM2 FASN IGF1R SVIL TMPRSS3	9.93e-05	200	187	8	M5906
Coexpression	GSE24210_TCONV_VS_TREG_DN	IRF6 TYMS TGM2 BAZ1A CHEK2 KLHL12 PLCG1 ARHGAP21	9.93e-05	200	187	8	M7844
Coexpression	NABA_MATRISOME_ASSOCIATED	HGFAC EGLN3 MMP28 ADAM18 ADAMTS8 ADAM11 ADAM32 ASTL F13A1 PIK3IP1 IFNW1 TGM2 EGF CX3CL1 CTSZ SEMA3E	1.03e-04	751	187	16	M5885
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	BOC FLNA TUT4 CAPN6 ITGA8 HEPH FBN1 FBN2 HMCN1 CACNA1G ADGRL2 MYRF SEMA3E	1.22e-05	354	182	13	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k3_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_1000	BOC FLNA TUT4 ERN1 POLA1 RPS6KA2 CAPN6 ITGA8 DCBLD1 FBN1 FBN2 F11R HMCN1 ACAA2 CACNA1G ADGRL2 MYRF KCNT1 SEMA3E	4.55e-05	783	182	19	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_1000
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_1000	BOC TUT4 PHLDA1 AVL9 GATA2 PTGER4 HEPH PIK3IP1 TGM2 FBN1 FBN2 NDUFAF1 HMCN1 ABCA5 SLC26A7 SVIL LRRTM4 ADGRL2 KAT14	5.21e-05	791	182	19	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN STAB2 ZAN OBSCN CSMD3 SSPOP DNAH1 FBN2 HMCN1 OTOGL CSMD1 SPAG17 USH2A	1.05e-12	184	186	13	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN STAB2 ZAN OBSCN CSMD3 SSPOP DNAH1 FBN2 HMCN1 OTOGL CSMD1 SPAG17 USH2A	1.05e-12	184	186	13	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN STAB2 ZAN OBSCN CSMD3 SSPOP DNAH1 FBN2 HMCN1 OTOGL CSMD1 SPAG17 USH2A	1.05e-12	184	186	13	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	BOC RELN MXRA5 CAPN6 TGM2 FBN1 FBN2 SVIL CSMD1 TMEM100 SEMA3E	3.86e-10	185	186	11	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	BOC MXRA5 CAPN6 ITGA8 TGM2 FBN1 FBN2 SVIL CACNA1G SEMA3E	6.86e-09	187	186	10	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MXRA5 TBX4 ITGA8 GAS7 F13A1 HEPH FBN1 HMCN1 LRRTM4 CACNA1G	1.30e-08	200	186	10	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSMD3 OTOGL AGFG1 ROCK1 IRS2 CSMD1 SPAG17 USH2A TET3	9.35e-08	186	186	9	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	SELE HSPG2 RELN STARD8 MMP28 GATA2 TGM2 FBN1 HMCN1	1.28e-07	193	186	9	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	SELE HSPG2 RELN STARD8 MMP28 GATA2 TGM2 FBN1 HMCN1	1.28e-07	193	186	9	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SELE ADGRG3 TBX4 GATA2 SLFN12 IRF6 HMCN1 BSG	1.30e-07	139	186	8	34398a6f21a1e670497655a7bb7f3cde9e117560
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SELE ADGRG3 TBX4 GATA2 SLFN12 IRF6 HMCN1 BSG	1.30e-07	139	186	8	450c4152c9fe4ec503271bb3cf93739918c59509
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BOC MXRA5 ITGA8 GAS7 F13A1 FBN1 LRRTM4 CACNA1G ADGRL2	1.73e-07	200	186	9	fb53be20392a8309a7393774c774a1b1aec6e676
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MXRA5 PHLDA1 RPS6KA2 OBSCN ITGA8 CSMD3 FBN2 ADGRL2	7.24e-07	174	186	8	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCBLD1 GRB14 TEKT5 SPRYD7 F11R ADGRL2 CX3CL1 TMEM100	9.74e-07	181	186	8	cd81bc307e2bc42c1e9b24d5645ab65fa18c6133
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HGFAC EGLN3 RELN ADGRG3 ZAN TEKT5 TGM2 F11R	1.02e-06	182	186	8	d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	BOC MXRA5 CAPN6 ITGA8 FBN1 FBN2 SVIL SEMA3E	1.20e-06	186	186	8	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 MMP28 NCKAP5 AQP5 FBN2 MYRF FBN3 SEMA3E	1.24e-06	187	186	8	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STARD8 GATA2 DCBLD1 GRB14 F11R AGFG1 ADGRL2 CX3CL1	1.30e-06	188	186	8	db0652f000d459493321b53239326706eace598c
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 EGLN3 MMP28 RPS6KA2 GATA2 NCKAP5 TGM2 TMEM100	1.30e-06	188	186	8	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	PND10-Epithelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBPJL ETV5 GRB14 AQP5 FASN BRD7 SPAG17 SEMA3E	1.35e-06	189	186	8	89349e226a5512833a94b1bf68056a6985fe4afd
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STARD8 GATA2 DCBLD1 GRB14 SPRYD7 AGFG1 ADGRL2 CX3CL1	1.40e-06	190	186	8	52213cd2a6a20772d4f49ba9ac0407abafa528db
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	FLNA TBX4 ITGA8 NCKAP5 ADAMTS8 NRP2 F11R HMCN1	1.58e-06	193	186	8	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 GATA2 DCBLD1 HMCN1 PLCG1 ADGRL2 CX3CL1 TMEM100	1.64e-06	194	186	8	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TBX4 ITGA8 GAS7 ADAMTS8 CSMD3 TGM2 FBN1 HMCN1	1.64e-06	194	186	8	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP1 MMP28 ETV5 CSMD3 SLC2A5 LRBA HERC2 ADGRL2	1.70e-06	195	186	8	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 GATA2 DCBLD1 GRB14 TEKT5 AGFG1 ADGRL2 CX3CL1	1.70e-06	195	186	8	cad21edd90bf3e2fefdf5773a59cb1a664a69ddd
ToppCell	facs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STARD8 DCBLD1 GRB14 TEKT5 SPRYD7 AGFG1 ADGRL2 CX3CL1	1.70e-06	195	186	8	7e0ef92059ff34e368d2324815f49b50e3ca7332
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Late_cap\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 EGLN3 MMP28 RPS6KA2 GATA2 NCKAP5 TGM2 TMEM100	1.70e-06	195	186	8	dfc5da514fb34a2c318a5c4c61f44049fa43960e
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BOC ADGRG3 TBX4 ITGA8 ADAM11 FBN1 HMCN1 LRRTM4	1.70e-06	195	186	8	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	wk_15-18-Endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 EGLN3 RELN STAB2 MMP28 RPS6KA2 GATA2 TGM2	1.91e-06	198	186	8	dcf453e22dba90c0ae349fa6c3d4c20758bb95af
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	ITGA8 ADAMTS8 NRP2 TGM2 AKAP9 F11R HMCN1 N4BP2L2	1.91e-06	198	186	8	e0e47cf65774191981840b22905b2094b95abe0f
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HSPG2 EGLN3 MMP28 RPS6KA2 GATA2 TGM2 ADGRL2 TMEM100	1.98e-06	199	186	8	243b7c72f83c12a34d8ea300fca63b04216268a4
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	KRT3 RELN CSMD3 FBN2 LRRTM4 CSMD1 USH2A	2.75e-06	146	186	7	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TET2 NRIP1 ADGRG3 TRIM25 SLC2A5 PIK3CB LPXN	5.04e-06	160	186	7	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN STAB2 RPS6KA2 GAS7 HEPH NRP2 TMEM100	5.93e-06	164	186	7	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN STAB2 RPS6KA2 GAS7 HEPH NRP2 TMEM100	5.93e-06	164	186	7	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN STAB2 RPS6KA2 GAS7 HEPH NRP2 TMEM100	5.93e-06	164	186	7	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	RELN ADGRG3 STAB2 GAS7 NRP2 FBN1 TMEM100	6.68e-06	167	186	7	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	droplet-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 FLNA EGLN3 SLC5A1 TGM2 AJUBA MYRF	7.22e-06	169	186	7	53690d6f9712b54aa99a0408aae930d64ae478e5
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 TBX4 RPS6KA2 F13A1 NRP2 FCRLB	8.10e-06	172	186	7	a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCell	PND28-Endothelial-Endothelial_lymphatic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN SLFN12 ACSF2 NSUN2 NRP2 TGM2 LLGL1	8.42e-06	173	186	7	2978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN SLFN12 ACSF2 NSUN2 NRP2 TGM2 LLGL1	8.42e-06	173	186	7	23d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT72 ADAM18 HEPACAM2 SLC2A5 OVOL1 CSMD1 CTSZ	8.42e-06	173	186	7	b75353fcbc9f8cdb21d4f10ddbc93a83fd797a3c
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN SLFN12 ACSF2 NSUN2 NRP2 TGM2 LLGL1	8.42e-06	173	186	7	03b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN SLFN12 ACSF2 NSUN2 NRP2 TGM2 LLGL1	8.42e-06	173	186	7	12da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NCKAP5 ACSF2 CUBN SLC2A5 SLC5A1 ARSF CSMD1	9.41e-06	176	186	7	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PHLDA1 GRB14 HEPACAM2 HCN2 ABCA5 SLC26A7 FBN3	9.77e-06	177	186	7	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 RPS6KA2 NRP2 STRN HMCN1 DISP2	9.77e-06	177	186	7	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TBX4 GATA2 SLFN12 IRF6 HMCN1 BSG	1.08e-05	119	186	6	a3807e738d7ca8cf80aa4bd35e3ee4357b1dc00f
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TBX4 GATA2 SLFN12 IRF6 HMCN1 BSG	1.08e-05	119	186	6	8a3f0a3ed9f80d7b061162e9fa519bb09804a86c
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TBX4 GATA2 SLFN12 IRF6 HMCN1 BSG	1.08e-05	119	186	6	938da0fe90372709048bf4e5503cc1cbf8376b17
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE RELN ADGRG3 IRF6 TGM2 HMCN1 DISP2	1.13e-05	181	186	7	cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCell	droplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA2 SLFN12 SYBU NRP2 F11R PIK3CB CHEK2	1.13e-05	181	186	7	92d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 STARD8 NRP2 STRN HMCN1 DISP2	1.13e-05	181	186	7	4df7972f88117108698efd06b124b232f8588981
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 STARD8 NRP2 STRN HMCN1 DISP2	1.13e-05	181	186	7	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A15 GRB14 EGF HMCN1 ABCA5 LRBA ADGRL2	1.17e-05	182	186	7	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELE HSPG2 ZAN MMP28 GATA2 FBN1 HMCN1	1.17e-05	182	186	7	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE HSPG2 GATA2 SLFN12 HEPH NRP2 HMCN1	1.17e-05	182	186	7	ab5761bf9af439231cd0f487b6467e372672a517
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN STAB2 RPS6KA2 GAS7 NRP2 FBN1 TMEM100	1.17e-05	182	186	7	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN STAB2 RPS6KA2 GAS7 NRP2 FBN1 TMEM100	1.17e-05	182	186	7	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN STAB2 RPS6KA2 GAS7 NRP2 FBN1 TMEM100	1.17e-05	182	186	7	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE HSPG2 GATA2 SLFN12 HEPH NRP2 HMCN1	1.17e-05	182	186	7	3b4dbf61ca0fe50efe05449815630e301cb76630
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	NCKAP5 AQP5 SLC5A1 SPRYD7 F11R MYRF FBN3	1.26e-05	184	186	7	cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	NCKAP5 AQP5 SLC5A1 SPRYD7 F11R MYRF FBN3	1.26e-05	184	186	7	bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRB14 GAS7 ADAM11 CSMD3 LRRTM4 CSMD1 SEMA3E	1.26e-05	184	186	7	da8d6e7944eb35e6cbea2feb7cbc2894787d723f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRB14 HEPACAM2 HCN2 ABCA5 SLC26A7 BSG FBN3	1.30e-05	185	186	7	9438097e94219c1db922b8507e3a29106d32a923
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ADGRG3 AVL9 GATA2 CUL7 CLCN5 EXOC1	1.30e-05	185	186	7	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX4 GRB14 GAS7 ADAM11 HCN2 LRRTM4 SEMA3E	1.35e-05	186	186	7	adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 RELN STAB2 RPS6KA2 NRP2 FBN1 TMEM100	1.44e-05	188	186	7	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 RELN STAB2 RPS6KA2 NRP2 FBN1 TMEM100	1.44e-05	188	186	7	61ee7b152745164293d8a44ef91ee2393efbdca5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTGER4 PIK3IP1 RSBN1 IGF1R BAZ1A IRS2 ALG13	1.44e-05	188	186	7	939790f133eac9c12d08db6ddb5f08f5107844e3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 RELN STAB2 RPS6KA2 NRP2 FBN1 TMEM100	1.44e-05	188	186	7	3f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCell	droplet-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 GATA2 DCBLD1 GRB14 ADGRL2 CX3CL1 TMEM100	1.49e-05	189	186	7	7b6cb745c0a637d6addc105a79059ed488fced39
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A15 GRB14 EGF HMCN1 ABCA5 LRBA ADGRL2	1.49e-05	189	186	7	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A15 GRB14 EGF HMCN1 ABCA5 LRBA ADGRL2	1.49e-05	189	186	7	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|343B / Donor, Lineage, Cell class and subclass (all cells)	KLK12 TMPRSS4 HEPACAM2 AQP5 SLC5A1 CX3CL1 SEMA3E	1.49e-05	189	186	7	a8246acf31f02c85421268245afb651aa8788f14
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A15 GRB14 EGF CLCN5 HMCN1 ABCA5 LRBA	1.49e-05	189	186	7	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	KLK12 TMPRSS4 HEPACAM2 AQP5 SLC5A1 CX3CL1 SEMA3E	1.49e-05	189	186	7	b06471b1bebb990d5146bddfb8002401c6b099a0
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 DCBLD1 GRB14 SPRYD7 AGFG1 ADGRL2 CX3CL1	1.49e-05	189	186	7	09dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCell	EC-Sinusoidal_ECs\|World / Lineage and Cell class	SELE RELN STAB2 DCBLD1 NRP2 TGM2 F11R	1.49e-05	189	186	7	9a0956c8a7069ba3bd0fa56d052d6e514453e578
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRB14 HEPACAM2 HCN2 ABCA5 SLC26A7 BSG FBN3	1.55e-05	190	186	7	bb3b396d78887d5d6f93a05c8ed4d703591bf33f
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC TBX4 ADAMTS8 CACNA1G IRS2 CSMD1 SEMA3E	1.55e-05	190	186	7	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	droplet-Lung-nan-18m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBPJL ETV5 TMPRSS4 AQP5 DNAH1 FASN SPAG17	1.55e-05	190	186	7	b057bea6e55cef872290893b6e439bbcdcee2f2e
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC TBX4 ADAMTS8 CACNA1G IRS2 CSMD1 SEMA3E	1.55e-05	190	186	7	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	Club\|World / shred by cell class for parenchyma	KLK12 TMPRSS4 HEPACAM2 AQP5 SLC5A1 CX3CL1 SEMA3E	1.55e-05	190	186	7	1974d559d7fee6cb68065b18af8bd38b64910622
ToppCell	(7)_Epithelial-G_(Club-Clara_cells)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	KLK12 TMPRSS4 HEPACAM2 AQP5 SLC5A1 CX3CL1 SEMA3E	1.55e-05	190	186	7	593fd1451038b155826a48de4caa38f44406d0b9
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STARD8 DCBLD1 GRB14 TEKT5 SPRYD7 ADGRL2 CX3CL1	1.60e-05	191	186	7	40e617d3c93f03ae87baf6c0b2304b617f5fe782
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PHLDA1 GRB14 HEPACAM2 ABCA5 SLC26A7 BSG FBN3	1.60e-05	191	186	7	feec8617678b778475747ad406c80231e07fd6f7
ToppCell	droplet-Lung-18m-Epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBPJL ETV5 TMPRSS4 AQP5 DNAH1 FASN SPAG17	1.60e-05	191	186	7	1b59f1cad6c1a6a5938afa9195164918e3ff4e86
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRB14 HEPACAM2 HCN2 ABCA5 SLC26A7 BSG FBN3	1.65e-05	192	186	7	4842a55650fc4687c9184d498a8c05c259d15186
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 GATA2 DCBLD1 AGFG1 ADGRL2 CX3CL1 TMEM100	1.65e-05	192	186	7	2360824910cd471c8286ca369ba144d90d984602
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 AQP5 F11R ABCA5 BSG MYRF SEMA3E	1.65e-05	192	186	7	b2d9bffccd6264b4f12d88a0780646ee0b41969f
ToppCell	Epithelial\|World / shred on cell class and cell subclass (v4)	RBPJL ETV5 AQP5 FASN AKAP9 BSG SEMA3E	1.65e-05	192	186	7	13a3553d9a7c78535679d23d454c63fd08f7d218
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 AQP5 F11R ABCA5 BSG MYRF SEMA3E	1.65e-05	192	186	7	790282d4232311df3dac4ad97c80fc53443beccc
ToppCell	Endothelial-Endothelial-B\|Endothelial / shred on cell class and cell subclass (v4)	STARD8 PHLDA1 DCBLD1 GRB14 AGFG1 ADGRL2 TMEM100	1.65e-05	192	186	7	f8d7bd81e031d09a557722627c2f6180811cc6ab
ToppCell	PND03-Epithelial-Epithelial_Alveolar\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBPJL ETV5 AQP5 FASN BSG BRD7 SEMA3E	1.71e-05	193	186	7	5dfa69a680a0859900141c40a446d217aaa747d3
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBPJL ETV5 AQP5 FASN BSG BRD7 SEMA3E	1.71e-05	193	186	7	ebea35704ac5d21e947ae094313cf2a5205e7014
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ADAM18 ETV5 SYBU HEPACAM2 PTGER4 NRP2	1.71e-05	193	186	7	6a9bce5064938b5b84ad57b4fd4a7841afe100c8
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 GATA2 DCBLD1 AGFG1 ADGRL2 CX3CL1 TMEM100	1.71e-05	193	186	7	ac1073bf4d3868841226b850b058f1e27326a14e
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TET2 FLNA ADGRG3 PHLDA1 TGM2 DGAT2 AGFG1	1.71e-05	193	186	7	5703a6faaee82cbad5ce73429bdf1b0f47b37ee0
Drug	4-HT	HGFAC TRIM25 ACO2 NSUN2 SAFB IGF1R EGF SAFB2	2.33e-06	105	185	8	CID005284643
Drug	Fatty Acids	SLC2A5 SLC5A1 FASN IGF1R UCP3 IRS2	5.53e-06	55	185	6	ctd:D005227
Drug	forskolin; Up 200; 50uM; MCF7; HT_HG-U133A_EA	PHLDA1 RPS6KA2 SYBU PIK3IP1 IGF1R AKAP9 SVIL TMPRSS3 IRS2	5.72e-06	157	185	9	913_UP
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2 FBN3	2.42e-07	3	185	3	DOID:65 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	BOC FLNA NRIP1 STARD8 ACO2 OBSCN HEPACAM2 KEAP1 CUBN SLC2A5 TYMS TGM2 FASN IGF1R LLGL1 AKAP9 EGF OTOGL PIK3CB CHEK2 LRBA HERC2	1.17e-06	1074	185	22	C0006142
Disease	Breast Carcinoma	FLNA NRIP1 STARD8 SLC2A5 TYMS TGM2 FASN IGF1R LLGL1 EGF PIK3CB CHEK2 HERC2	3.82e-05	538	185	13	C0678222
Disease	spermatogenesis-associated protein 20 measurement	SPATA20 CACNA1G	3.91e-05	2	185	2	EFO_0802083
Disease	refractive error (implicated_via_orthology)	PRSS56 FBN1	3.91e-05	2	185	2	DOID:9835 (implicated_via_orthology)
Disease	Colorectal Carcinoma	BOC TET2 STARD8 CAPN6 SLC22A15 OBSCN CUBN CSMD3 TYMS TGM2 FBN2 AKAP9 ABCA5 CHEK2 SPAG17	3.98e-05	702	185	15	C0009402
Disease	testosterone measurement	TET2 HGFAC STARD8 ZAN POR GRB14 TMPRSS4 CSMD3 ERLIN1 IFNW1 FASN C3P1 OVOL1 FBN2 HMCN1 CHEK2 PLCG1 ADGRL2 USP48 USH2A ARHGAP21	5.44e-05	1275	185	21	EFO_0004908
Disease	Dent disease (implicated_via_orthology)	CLCN3 CLCN5	1.17e-04	3	185	2	DOID:0050699 (implicated_via_orthology)
Disease	lysophosphatidylcholine 17:0 measurement	ACAA2 MYRF	1.17e-04	3	185	2	EFO_0021452
Disease	Disproportionate short stature	HSPG2 FLNA CUL7 SLC35D1 FBN1	1.26e-04	77	185	5	C0878659
Disease	breast cancer (is_marker_for)	TET2 TUT4 IGF1R THRA F11R SETD5 PLCG1	1.75e-04	185	185	7	DOID:1612 (is_marker_for)
Disease	dimethylglycine measurement	ERCC5 CSMD3 CACNA1G ADGRL2	1.99e-04	46	185	4	EFO_0010476
Disease	bitter alcoholic beverage consumption measurement	RELN SEZ6L2 SETD5 IGSF9B CSMD1 TET3	1.99e-04	133	185	6	EFO_0010092
Disease	Osteochondrodysplasias	HSPG2 FLNA THRA	2.18e-04	19	185	3	C0029422
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	2.33e-04	4	185	2	DOID:0060249 (is_implicated_in)
Disease	age-related macular degeneration, cataract, glaucoma	PCDHGA5 HERC2	2.33e-04	4	185	2	EFO_0001365, MONDO_0005041, MONDO_0005129
Disease	Alzheimer disease, age at onset	HSPG2 ERN1 CSMD3 F13A1 OTOGL RPTOR SVIL HERC2 USH2A	3.35e-04	343	185	9	EFO_0004847, MONDO_0004975
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	TET2 ERN1 KEAP1 CUL7 CSMD3 TGM2	3.53e-04	148	185	6	C0279702
Disease	Colorectal Neoplasms	BOC TET2 STARD8 SLC22A15 TYMS FBN2 ABCA5 CHEK2	3.81e-04	277	185	8	C0009404
Disease	Liver carcinoma	HGFAC STAB2 PHLDA1 ACO2 TYMS FASN IGF1R EGF IRS2 CSMD1 LILRB5	3.81e-04	507	185	11	C2239176
Disease	Myelodysplastic syndrome	TET2 GATA2	3.86e-04	5	185	2	cv:C3463824
Disease	MYELODYSPLASTIC SYNDROME	TET2 GATA2	3.86e-04	5	185	2	614286
Disease	Mammary Carcinoma, Human	FLNA NRIP1 STARD8 SLC2A5 TYMS TGM2 FASN IGF1R LLGL1 EGF CHEK2	5.10e-04	525	185	11	C4704874
Disease	Mammary Neoplasms, Human	FLNA NRIP1 STARD8 SLC2A5 TYMS TGM2 FASN IGF1R LLGL1 EGF CHEK2	5.10e-04	525	185	11	C1257931
Disease	Mammary Neoplasms	FLNA NRIP1 STARD8 SLC2A5 TYMS TGM2 FASN IGF1R LLGL1 EGF CHEK2	5.26e-04	527	185	11	C1458155
Disease	type 2 diabetes mellitus (implicated_via_orthology)	ADAMTS8 IGF1R PIK3CB UCP3 IRS2	5.34e-04	105	185	5	DOID:9352 (implicated_via_orthology)
Disease	trefoil factor 1 measurement	TMPRSS4 TMPRSS3	5.77e-04	6	185	2	EFO_0021865
Disease	oligoasthenoteratozoospermia (implicated_via_orthology)	SPATA20 AGFG1	5.77e-04	6	185	2	DOID:0070311 (implicated_via_orthology)
Disease	free androgen index	TET2 HGFAC POR TMPRSS4 IFNW1 OVOL1 CHEK2 USP48 ARHGAP21	6.24e-04	374	185	9	EFO_0007005
Disease	cortical thickness	HSPG2 EGLN3 RELN EXD1 RPS6KA2 GAS7 NCKAP5 SYBU ADAMTS8 NRP2 STRN IGF1R FBN1 FBN2 SETD5 BAZ1A ARHGAP21	6.74e-04	1113	185	17	EFO_0004840
Disease	glucose metabolism disease (implicated_via_orthology)	IGF1R PIK3CB IRS2	7.08e-04	28	185	3	DOID:4194 (implicated_via_orthology)
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	FASN IGF1R DGAT2 IRS2	7.51e-04	65	185	4	DOID:0080208 (biomarker_via_orthology)
Disease	osteopetrosis (implicated_via_orthology)	CLCN3 CLCN5	8.04e-04	7	185	2	DOID:13533 (implicated_via_orthology)
Disease	remission	HSPG2 RPTOR	8.04e-04	7	185	2	EFO_0009785
Disease	autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis	KEAP1 RSBN1 SUOX ADGRL2	9.93e-04	70	185	4	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Disease	hepatocellular carcinoma (is_implicated_in)	TET2 ERN1 TYMS IGF1R EGF PLCG1	1.02e-03	181	185	6	DOID:684 (is_implicated_in)
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	ITGA8 FBN1	1.07e-03	8	185	2	DOID:4783 (biomarker_via_orthology)
Disease	Sarcomatoid Renal Cell Carcinoma	TET2 KEAP1 CUL7 CSMD3 TGM2	1.30e-03	128	185	5	C1266043
Disease	Chromophobe Renal Cell Carcinoma	TET2 KEAP1 CUL7 CSMD3 TGM2	1.30e-03	128	185	5	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	TET2 KEAP1 CUL7 CSMD3 TGM2	1.30e-03	128	185	5	C1266044
Disease	Papillary Renal Cell Carcinoma	TET2 KEAP1 CUL7 CSMD3 TGM2	1.30e-03	128	185	5	C1306837
Disease	Renal Cell Carcinoma	TET2 KEAP1 CUL7 CSMD3 TGM2	1.30e-03	128	185	5	C0007134
Disease	mitral valve prolapse (is_implicated_in)	FLNA FBN1	1.37e-03	9	185	2	DOID:988 (is_implicated_in)
Disease	intraocular pressure measurement	EGLN3 RELN MXRA5 PCDHGA5 GAS7 ADAMTS8 FBN1 FBN2 HERC2 SEMA3E	1.47e-03	509	185	10	EFO_0004695
Disease	creatinine measurement	TET2 HGFAC TBX4 TMC6 OBSCN POR ETV5 SPATA20 CUBN F13A1 SLC35D1 IGF1R OVOL1 SVIL ADGRL2	1.59e-03	995	185	15	EFO_0004518
Disease	age at onset, multiple sclerosis	RELN NCKAP5	1.70e-03	10	185	2	EFO_0004847, MONDO_0005301
Disease	Prostatic Neoplasms	TET2 STAB2 ETV5 ADAMTS8 KEAP1 TYMS EGF PIK3CB UCP3 CHEK2 CX3CL1	1.84e-03	616	185	11	C0033578
Disease	Malignant neoplasm of prostate	TET2 STAB2 ETV5 ADAMTS8 KEAP1 TYMS EGF PIK3CB UCP3 CHEK2 CX3CL1	1.84e-03	616	185	11	C0376358
Disease	ascending aortic diameter	GATA2 FBN1 FBN2 HMCN1 DISP2	1.93e-03	140	185	5	EFO_0021787
Disease	acute myeloid leukemia (is_implicated_in)	TET2 GATA2 TYMS BRD7	1.95e-03	84	185	4	DOID:9119 (is_implicated_in)
Disease	Autism Spectrum Disorders	RELN NSUN2 USH2A TET3	2.04e-03	85	185	4	C1510586
Disease	Microphthalmos	PRSS56 MYRF	2.07e-03	11	185	2	C0026010
Disease	Macrocephaly	THRA TET3	2.07e-03	11	185	2	C0221355
Disease	Neoplasm of uncertain or unknown behavior of breast	PIK3CB CHEK2 HERC2	2.17e-03	41	185	3	C0496956
Disease	Breast adenocarcinoma	PIK3CB CHEK2 HERC2	2.17e-03	41	185	3	C0858252
Disease	Cleft palate, isolated	IRF6 TYMS EGF	2.33e-03	42	185	3	C1837218
Disease	rosacea severity measurement	SYBU IGF1R HERC2 SEMA3E ALG13	2.39e-03	147	185	5	EFO_0009180
Disease	level of Phosphatidylinositol (18:1_18:1) in blood serum	ACAA2 MYRF	2.91e-03	13	185	2	OBA_2045159
Disease	gallbladder cancer (is_implicated_in)	KEAP1 EGF	2.91e-03	13	185	2	DOID:3121 (is_implicated_in)
Disease	platelet component distribution width	NRIP1 STARD8 ETV5 CUBN IGF1R EGF DGAT2 SVIL CHEK2 N4BP2L2 IRS2 CTSZ	3.02e-03	755	185	12	EFO_0007984
Disease	hypertension (biomarker_via_orthology)	HSPG2 AQP2 IGF1R FBN1 F11R UCP3	3.18e-03	227	185	6	DOID:10763 (biomarker_via_orthology)
Disease	pulse pressure measurement, social deprivation	ADAMTS8 FBN1	3.39e-03	14	185	2	EFO_0005763, EFO_0009696
Disease	glycodeoxycholate measurement	SVIL CSMD1	3.39e-03	14	185	2	EFO_0010493
Disease	glucose-dependent insulinotropic peptide measurement, glucose tolerance test	F13A1 SLC5A1	3.39e-03	14	185	2	EFO_0004307, EFO_0008464
Disease	triacylglycerol 52:1 measurement	SLC22A15 CSMD1	3.39e-03	14	185	2	EFO_0010413
Disease	serum alanine aminotransferase measurement	HGFAC NRIP1 MMP28 ETV5 GRB14 ERLIN1 STRN FBN1 CHEK2 N4BP2L2 USP48 MYRF SEMA3E	3.44e-03	869	185	13	EFO_0004735
Disease	glycerophospholipid measurement	SPATA20 MYRF FBN3	3.61e-03	49	185	3	EFO_0007630
Disease	acute myeloid leukemia (is_marker_for)	TET2 GATA2 BRD7	3.61e-03	49	185	3	DOID:9119 (is_marker_for)
Disease	mammographic density measurement	ADAMTS8 SPAG17 TET3	3.83e-03	50	185	3	EFO_0005941
Disease	Disease Exacerbation	KEAP1 ACAD8 CLCN3 EGF CHEK2	3.92e-03	165	185	5	C0235874
Disease	response to tenofovir	RELN SLC2A5 ADGRL2	4.05e-03	51	185	3	EFO_0009279
Disease	chronic obstructive pulmonary disease	BOC TET2 PCDHGA5 ITGA8 TEKT5 NRP2 THRA LLGL1 HMCN1 SVIL POFUT1	4.27e-03	688	185	11	EFO_0000341
Disease	Spondyloepiphyseal Dysplasia	HSPG2 FLNA	4.43e-03	16	185	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	HSPG2 FLNA	4.43e-03	16	185	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	HSPG2 FLNA	4.43e-03	16	185	2	C4551479
Disease	Schwartz-Jampel Syndrome	HSPG2 FLNA	4.43e-03	16	185	2	C0036391
Disease	Drug-induced agranulocytosis	ADGRL2 TMEM100	4.43e-03	16	185	2	HP_0012235
Disease	Melnick-Needles Syndrome	HSPG2 FLNA	4.43e-03	16	185	2	C0025237
Disease	age-related hearing impairment	EGLN3 TMPRSS4 CSMD3 LLGL1 TMPRSS3 CSMD1 SPAG17	4.50e-03	324	185	7	EFO_0005782
Disease	Familial thoracic aortic aneurysm and aortic dissection	FLNA FBN1 FBN2	4.51e-03	53	185	3	C4707243
Disease	Heschl's gyrus morphology measurement	FBN2 DISP2 ACAA2	4.51e-03	53	185	3	EFO_0005852
Disease	refractive error	NRIP1 ACO2 PRSS56 FBN1 ACAA2 MYRF FBN3	4.65e-03	326	185	7	MONDO_0004892
Disease	upper aerodigestive tract neoplasm	NCKAP5 STRN SLC26A7 SVIL CHEK2 ADGRL2	4.70e-03	246	185	6	EFO_0004284
Disease	FEV/FEC ratio	BOC TET2 HSPG2 TPRA1 PCDHGA5 ITGA8 DCBLD1 TEKT5 NRP2 FBN1 HMCN1 SUOX SVIL POFUT1 CSMD1 AJUBA	4.71e-03	1228	185	16	EFO_0004713
Disease	alkaline phosphatase measurement	SELE TET2 HSPG2 ERN1 DHX38 RSBN1 LLGL1 CHEK2 N4BP2L2 LRBA USP48 MYRF ARHGAP21 PHLPP2	4.96e-03	1015	185	14	EFO_0004533
Disease	phosphatidylcholine 40:6 measurement	CSMD1 MYRF	5.00e-03	17	185	2	EFO_0010389
Disease	Van Buchem disease	HSPG2 FLNA	5.00e-03	17	185	2	C0432272
Disease	RS-10-hydroxywarfarin to RS-warfarin ratio measurement	CAMK1G SLC26A7 ARHGAP21 FBN3	5.15e-03	110	185	4	EFO_0803335
Disease	serum gamma-glutamyl transferase measurement	HGFAC AAMP CSMD3 STRN IGF1R PTCD1 SVIL CHEK2 PLCG1 LRBA CSMD1 ADGRL2 ARHGAP21	5.22e-03	914	185	13	EFO_0004532
Disease	borna disease (biomarker_via_orthology)	ATF4 CX3CL1	5.60e-03	18	185	2	DOID:5154 (biomarker_via_orthology)
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	ACAA2 MYRF	5.60e-03	18	185	2	OBA_2045155
Disease	left ventricular mass	SEZ6L2 IGF1R	5.60e-03	18	185	2	EFO_0009289
Disease	Autistic Disorder	RELN CUL7 CSMD3 SEZ6L2 NRP2 EGF	6.23e-03	261	185	6	C0004352
Disease	osteochondrodysplasia (is_implicated_in)	HSPG2 FLNA	6.23e-03	19	185	2	DOID:2256 (is_implicated_in)
Disease	Dyschondroplasias	HSPG2 FLNA	6.23e-03	19	185	2	C0013366

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPVSSIYMDSRAGCS	ABCA5	146	Q8WWZ7
LIGSCTNSSYEDMGR	ACO2	381	Q99798
GCYGNDTMRTPHIDR	ARSF	46	P54793
ITESDAQRTMYPGSC	AKAP9	1391	Q99996
IHYTGCSMNPARSLA	AQP2	176	P41181
TMVPATSGYCVGRRG	ALG13	756	Q9NP73
GDIGCYGNNTMRTPN	ARSL	51	P51690
PGYAMHGSNTLTCLS	CSMD1	1246	Q96PZ7
YSTLTCIMGDDGRPG	CSMD3	1736	Q7Z407
PGYTMELNGSRIRTC	CSMD3	3201	Q7Z407
IYANGPISCGIMATE	CTSZ	206	Q9UBR2
GESDIYVVMCRTGGP	ACAD8	196	Q9UKU7
CSVMPLAAVGYLDGT	AAMP	326	Q13685
YCPVRLGMTTGRLQS	BRD7	366	Q9NPI1
RPCSNRTSGISMGYD	AJUBA	156	Q96IF1
SPCSAMYLTELLDGG	ADAMTS8	406	Q9UP79
GTDNAYVADGTMCGP	ADAM18	591	Q9Y3Q7
DNDSGICMSPESYLG	ATF4	216	P18848
VPCGTSGGVMIYIDR	ERLIN1	76	O75477
LSYVEDGTACGPNML	ADAM11	646	O75078
EGPRNTCLGSNNMYD	ADGRG3	26	Q86Y34
CPGSDVIMIESANYG	ADGRL2	51	O95490
LGAVFPGTMCITRYS	ADAM32	286	Q8TC27
PGTMCITRYSAGVAL	ADAM32	291	Q8TC27
QPDFSSYDISTMCGG	ACSF2	366	Q96CM8
PKNSMCSGLIISSGY	ACTR5	176	Q9H9F9
CDSRASTVSPGGYMV	AHDC1	1056	Q5TGY3
VVGSMDGHPSRYCAT	AGO4	606	Q9HCK5
GETSLMRTLCGTPTY	CHEK2	376	O96017
MANTTEYRTLCPGGE	FBN3	1536	Q75N90
TCPAGYTLREDGAMC	FBN3	2191	Q75N90
TRQAELGLAYGAPCM	CBY3	111	A6NI87
YLSEGPSSCSMGIRS	CENPP	196	Q6IPU0
SVGGMPGSCSEQYEL	DISP2	1151	A7MBM2
ERSKAMVACYPGNGT	EGLN3	116	Q9H6Z9
SIIPMYGCFSSVGRS	ASTL	146	Q6HA08
SRGRSSNAYDPSQMC	BAZ1A	956	Q9NRL2
GIYFTGCSMNPARSF	AQP5	176	P55064
TGPTVCGYMGLDSAS	RBPJL	116	Q9UBG7
MCSSFATGPRQYDGI	NIPSNAP3A	21	Q9UFN0
YVCRVMGSSGPLEAS	HSPG2	2791	P98160
ITPMCEVTGGRSYSV	INTS6	196	Q9UL03
EVTGGRSYSVCSPRM	INTS6	201	Q9UL03
GTLCEPGSGQIRYSM	PCDHGA5	21	Q9Y5G8
GMPRASYGDRHCVSV	LLGL1	311	Q15334
AEGGRMVYSTCSLNP	NSUN2	311	Q08J23
VTEGMDDFRYGCQSP	FAM47C	51	Q5HY64
RPRNIMVYNCTTGST	FAR1	296	Q8WVX9
MDISVNGSGPCTYTI	LRRTM4	496	Q86VH4
CMATYGEGDPTDNAQ	POR	136	P16435
CTAGGAYVPAMADEN	MCCC2	216	Q9HCC0
YPGRITSNMVCAGGV	KLK12	176	Q9UKR0
TGYELETMVCGSPDI	HERC2	4666	O95714
YRMSGECPSAVSISV	KRT3	511	P12035
METGGYLPNCITTLQ	EXD1	191	Q8NHP7
TTPGSGYLCAMKITE	KCNT1	981	Q5JUK3
ECPSGFIRNGSQSMY	IGF1R	306	P08069
CALPNMGLGSSRLQY	PTGER4	151	P35408
EDSSYMPARVVVCGG	CUL7	896	Q14999
TVAGCLSVGSPMYFR	KAT14	176	Q9H8E8
RSPVCMEFQYQATGG	NRP2	711	O60462
AYPGCDAGIRAMALS	LRBA	2816	P50851
YDQRCIISGMASGSI	LRBA	2831	P50851
SNPERGYMNCLPSAS	SELE	371	P16581
PSSCMDNRTFSYPGV	NRIP1	991	P48552
QENSDGMYRCGPASV	F13A1	401	P00488
GGCNRPVLENYLSAM	LPXN	271	O60711
SMSPVTSAQGGTYRC	LILRB5	381	O75023
VDSEVPNCQSSYMRG	ETV5	301	P41161
VSNMLLAEAYGSGGC	PIK3IP1	11	Q96FE7
EVYGADISPNMLCAG	HGFAC	571	Q04756
FDGSGTDMEPSLYRC	POLA1	1296	P09884
CDLGNPMVSGTNYSL	ITGA8	726	P53708
RDSSYSMAPGPCVVA	OVOL1	66	O14753
LCTPSMDTTGYGNLR	RELN	461	P78509
GCEGNSRELSEPTMY	RELN	1346	P78509
GSEVSIMCSATGYPK	HMCN1	626	Q96RW7
TDTGRYLCMATNAAG	HMCN1	3776	Q96RW7
PMVRYCSGAQGSTLS	INO80B	271	Q9C086
EQNGIMSTACGTPGY	CAMK1G	171	Q96NX5
MPADAGVYRCQAGSA	OBSCN	2531	Q5VST9
MERVNDASCGPSGCY	PATZ1	1	Q9HBE1
SCAYSDLQSMGTGPD	NEU2	331	Q9Y3R4
CGGDSDQYVLMSSPV	IRS2	816	Q9Y4H2
LSLGPCRVGMENYAT	CCNYL3	216	P0C7X3
RGYSVMSTPFATVCG	CUBN	2986	O60494
SYSPAHARLTGGQMC	GATA2	71	P23769
SCAVFITMNPGYAGR	DNAH1	1676	Q9P2D7
LVMTSYSPVGSLGCD	IFNW1	11	P05000
MPAVRGEDSGIYSCV	IGSF1	1121	Q8N6C5
MTTPRCYVGATVLRG	KLHL12	506	Q53G59
PAGSGKSTYCATMVQ	GPN3	11	Q9UHW5
TYRCMADNGVGQPGA	BOC	296	Q9BWV1
SYMCRHGSTAEGPLG	CACNA1G	2051	O43497
GEGVISNPAMCYSSL	C3P1	346	Q6ZMU1
APVGCSMYARCISEG	EGF	836	P01133
ASPCRSSDGILYMGK	ERN1	106	O75460
ARGDSTYRCSYQPTM	FLNA	436	P21333
EYQALCSSGPGMTSA	FBN1	706	P35555
MGLYGQACPSVTSLR	FOXJ3	1	Q9UPW0
CSQYRPRKSMSEDGG	AVL9	236	Q8NBF6
SQGADCITPGLYAMV	CLCN5	561	P51795
APQDGESTRSGYCAM	NDUFAF1	171	Q9Y375
ESTRSGYCAMISRIP	NDUFAF1	176	Q9Y375
NMEADPGQYRCNGTS	BSG	291	P35613
SQCPEGAGDAVMYAS	KEAP1	21	Q14145
MHPYQGRSGCSSQSI	GRB14	351	Q14449
ARCYPGSGVTMEFTI	EXOC1	866	Q9NV70
PSGAVEYVGNMTLTC	HEPACAM2	156	A8MVW5
SDSGRYQCSGTMRIP	FCRLB	161	Q6BAA4
CSCSEGYALMPDGRS	FBN2	1266	P35556
SGNMVDGYRDTSLLC	DCBLD1	186	Q8N8Z6
GAGSSAMRDYCPSQQ	GPRIN1	36	Q7Z2K8
SRDPETLVGYSMVGC	FASN	121	P49327
TVDDDPLMNRSGGCY	CAPN6	361	Q9Y6Q1
PLMNRSGGCYNNRDT	CAPN6	366	Q9Y6Q1
YPTVIRNVGLGTCSM	SLC22A15	426	Q8IZD6
GKMTSLPLDTQCGDY	SEC24B	76	O95487
LCIGYGRQAPESMTD	HCN2	426	Q9UL51
EYLMSGGICPVSRDT	DGAT2	206	Q96PD7
ICGDEYGPETRLSMS	DHX9	611	Q08211
PASSYQSLCRMGSRV	FAM126B	196	Q8IXS8
CSGNGTEIMYTLQEP	OTOGL	2331	Q3ZCN5
PSTMLCAGYLAGGVD	PRSS56	266	P0CW18
VTRFGRSCTPAYSMQ	ODF3L2	96	Q3SX64
SCEARNGYGTPMTSN	F11R	211	Q9Y624
EYGQTMTVSNPQGCR	IRF6	236	O14896
MTVSNPQGCRLFYGD	IRF6	241	O14896
QCVGYSRSTAAPLTM	POFUT1	266	Q9H488
MTRPRCGVTDTNSYA	MMP28	86	Q9H239
CGTYRAGPMRQISLV	RSBN1	466	Q5VWQ0
VGIGDSCCGRMPYST	USH2A	3261	O75445
PNGLYLMSGSHDCSI	STRN	716	O43815
GARRYAPGSATMKEC	SSPOP	886	A2VEC9
LYPGTETMGLRTCAG	SVIL	166	O95425
DKAPRMCTYSASGGS	NCKAP5	1861	O14513
MSGARCRTLYPFSGE	GAS7	1	O60861
GICAGVSSNVVPMYL	SLC2A5	136	P22732
LSSCNYAPEDTGMSV	GCM2	411	O75603
EAGMRAIYNVSQCPG	HEPH	706	Q9BQS7
DYTEGIPTVGCVTAM	ERCC5	861	P28715
PGEEECRNGYSLMFS	SETD5	876	Q9C0A6
CTIRMNDAPTTGYSA	ST6GALNAC6	131	Q969X2
MEFLGTTQTASYCGP	TEKT5	1	Q96M29
ACGMENGFRVYNTDP	WDR45B	26	Q5MNZ6
GAAMLTCYSRDTGTP	SEZ6L2	741	Q6UXD5
MLPYGCLATGDRSGL	PIK3CB	836	P42338
NYRFPSSLCVGLGQM	SLC35D1	66	Q9NTN3
KNMHCPASGIRGTVY	SPRYD7	146	Q5W111
TSQYLMEPCGLGRSR	STARD8	961	Q92502
MGSPSIFVYDCSNAG	RPTOR	186	Q8N122
ARSPGARCYGFVTMS	SAFB	441	Q15424
CLSISYYGSNGMAPE	SPAG17	1131	Q6Q759
DCDQRGPTYVNMTVG	AGFG1	31	P52594
ADCITPGLYAMVGAA	CLCN3	566	P51790
CGGTESMSQAPYCVR	ACAA2	116	P42765
SPVYVGRVVSGMVNC	TGM2	216	P21980
SPSMLCAGYLTGGVD	TMPRSS3	381	P57727
AGGVAYLDDIASMPC	TPRA1	341	Q86W33
LTMVRTEGPCSPYNG	UCP3	66	P55916
ATNPDLGCMIRFYGE	PHLPP2	126	Q6ZVD8
TCVPYNTLGTMGQSA	IGSF9B	396	Q9UPX0
NSGSYKGSDCSPIMR	SYBU	231	Q9NX95
PSYAGRMLESSGCKA	PHLDA1	136	Q8WV24
VASGRLMRTCYTGPG	SPATA20	546	Q8TB22
VGICYGSMNRQGPES	TRIM25	526	Q14258
GSPASCMELELYGVD	TBCB	46	Q99426
DTCQGDSGGPLMYQS	TMPRSS4	381	Q9NRS4
SELSCQLYQRSGDMG	TYMS	206	P04818
TGRHCGYVLQPSTMR	PLCG1	1056	P19174
MCNSERSYGGIIPNT	TMPRSS12	236	Q86WS5
SPEGMTSCQYDLRSQ	SLFN12	501	Q8IYM2
GVKCPDGYTMITSGS	STAB2	51	Q8WWQ8
DYGMIGCTQPRRVAA	DHX38	576	Q92620
GPSRRSDLQSLGYCM	VRK3	366	Q8IV63
NARSPGARCYGFVTM	SAFB2	441	Q14151
SVLGNCRPSDPYSMN	TET3	1241	O43151
QLMAATGGTELSCYR	TMEM100	41	Q9NV29
EGMVRCDTAVGTPDY	ROCK1	226	Q13464
TSCMTGYSPQLQGLS	TMEM209	156	Q96SK2
RLVCSVPGMNGIDTY	SEMA3E	291	O15041
GQCSLKTSMSGYIPS	THRA	31	P10827
TGTAYGASIPLARAM	SUOX	326	P51687
CGPFRTLDTMYEAGR	TMC6	681	Q7Z403
VTPREACMYSGSGPE	TBX4	386	P57082
ACMYSGSGPEIAGVS	TBX4	391	P57082
PMESNYTVLIGGCGR	PTCD1	171	O75127
ITEFAYGTGSCMEPS	SLC5A1	501	P13866
PSAAAMGRTAGLYST	SLC26A7	361	Q8TE54
SQTDGGIPSYCFALM	TUT4	511	Q5TAX3
SVLMKYCPRSASQGA	ARHGAP21	466	Q5T5U3
YGIPCMKGSQNSRVS	TET2	61	Q6N021
PSTCSDYMLGDGIQE	USP48	121	Q86UV5
GVAMFTYQSLQGCPR	CX3CL1	356	P78423
MAEGLRYIPRSCGSN	CX3CL1	376	P78423
LPSMYEGLVSGLCGN	ZAN	2456	Q9Y493
CRMSGEYPNSVSISV	KRT72	436	Q14CN4
PTRRTNCGYESGDHM	LEG1	106	Q6P5S2
LRAGNGLLMTPCYTA	RPS6KA2	561	Q15349
RGTYVCRMETEYGPS	MXRA5	2706	Q9NR99
SVHPSGNGCSMQDRY	N4BP2L2	346	Q92802
MSITSQYCAPGDACR	MYRF	1026	Q9Y2G1