Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13 ALG13	7.44e-17	114	111	15	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13 ALG13	2.72e-16	124	111	15	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13 ALG13	1.25e-15	137	111	15	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L6P CAPN5 USP17L22 USP17L15 USP17L13 ALG13	1.04e-14	192	111	16	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	PAPPA2 HGF USP17L20 USP17L11 USP17L24 USP24 NUP98 USP17L5 USP17L10 USP17L19 NCSTN PRSS58 USP9Y USP17L18 MBTPS2 USP17L17 USP17L6P CAPN5 USP17L22 USP17L15 USP17L13 ALG13	9.43e-12	654	111	22	GO:0008233
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.22e-15	125	109	14	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	3.13e-14	144	109	14	GO:0070646
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	EPM2A USP17L20 USP17L11 USP17L24 HECTD4 USP24 USP17L5 USP17L10 USP17L19 HUWE1 USP9Y DDB1 HERC2P3 USP17L18 USP17L17 USP17L6P HERC3 USP17L22 FBXL2 USP17L15 USP17L13	6.17e-08	1009	109	21	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	EPM2A USP17L20 USP17L11 USP17L24 HECTD4 USP24 USP17L5 USP17L10 USP17L19 HUWE1 USP9Y DDB1 HERC2P3 USP17L18 USP17L17 USP17L6P HERC3 USP17L22 FBXL2 USP17L15 USP17L13	1.76e-07	1074	109	21	GO:0043687
GeneOntologyCellularComponent	mucus layer	MUC2 MUC5AC	8.05e-05	3	109	2	GO:0070701
GeneOntologyCellularComponent	endoplasmic reticulum membrane	EPM2A USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 NCSTN USP17L18 ABCG1 MBTPS2 USP17L17 USP17L6P USP17L22 ATP2A2 USP17L15 USP17L13 ALG13	3.72e-04	1293	109	17	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	EPM2A USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 NCSTN USP17L18 ABCG1 MBTPS2 USP17L17 USP17L6P USP17L22 ATP2A2 USP17L15 USP17L13 ALG13	3.92e-04	1299	109	17	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	EPM2A USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 NCSTN USP17L18 ABCG1 MBTPS2 USP17L17 USP17L6P USP17L22 ATP2A2 USP17L15 USP17L13 ALG13	5.00e-04	1327	109	17	GO:0042175
GeneOntologyCellularComponent	tight junction	ANK3 POF1B UBN1 EPHA2 SYMPK	8.12e-04	139	109	5	GO:0070160
Domain	HABP4_PAI-RBP1	USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	4.78e-17	16	106	9	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	4.78e-17	16	106	9	IPR006861
Domain	USP_CS	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L22 USP17L13	2.25e-15	66	106	12	IPR018200
Domain	USP_1	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L22 USP17L13	4.77e-15	70	106	12	PS00972
Domain	UCH	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L22 USP17L13	5.71e-15	71	106	12	PF00443
Domain	USP_2	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L22 USP17L13	5.71e-15	71	106	12	PS00973
Domain	USP_3	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L22 USP17L13	6.82e-15	72	106	12	PS50235
Domain	USP_dom	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L22 USP17L13	6.82e-15	72	106	12	IPR028889
Domain	Peptidase_C19_UCH	USP17L20 USP17L11 USP17L24 USP24 USP17L5 USP17L10 USP17L19 USP9Y USP17L18 USP17L17 USP17L22 USP17L13	6.82e-15	72	106	12	IPR001394
Domain	WxxW_domain	MUC2 MUC5AC	4.72e-04	6	106	2	IPR025155
Domain	Mucin2_WxxW	MUC2 MUC5AC	4.72e-04	6	106	2	PF13330
Domain	-	ASAP3 APPL1 ACAP2	6.45e-04	30	106	3	1.20.1270.60
Domain	AH/BAR-dom	ASAP3 APPL1 ACAP2	6.45e-04	30	106	3	IPR027267
Domain	Plexin_cytopl	PLXND1 PLXNB1	1.12e-03	9	106	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXND1 PLXNB1	1.12e-03	9	106	2	IPR013548
Domain	Plexin	PLXND1 PLXNB1	1.12e-03	9	106	2	IPR031148
Domain	TIL	MUC2 MUC5AC	2.03e-03	12	106	2	PF01826
Domain	C8	MUC2 MUC5AC	2.03e-03	12	106	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC2 MUC5AC	2.39e-03	13	106	2	IPR014853
Domain	C8	MUC2 MUC5AC	2.39e-03	13	106	2	SM00832
Domain	HEAT	CEP104 PRKDC SYMPK	2.55e-03	48	106	3	PF02985
Domain	TIL_dom	MUC2 MUC5AC	2.78e-03	14	106	2	IPR002919
Domain	-	FBXW10 PLXND1 WDR76 TEP1 DDB1 WDR87 PLXNB1	2.90e-03	333	106	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	FBXW10 PLXND1 WDR76 TEP1 DDB1 WDR87 PLXNB1	3.00e-03	335	106	7	IPR015943
Domain	VWD	MUC2 MUC5AC	3.64e-03	16	106	2	SM00216
Domain	VWF_type-D	MUC2 MUC5AC	3.64e-03	16	106	2	IPR001846
Domain	VWFD	MUC2 MUC5AC	3.64e-03	16	106	2	PS51233
Domain	VWD	MUC2 MUC5AC	3.64e-03	16	106	2	PF00094
Domain	HEAT	CEP104 PRKDC SYMPK	4.37e-03	58	106	3	IPR000357
Domain	Cation_ATPase_N	ATP13A5 ATP2A2	4.60e-03	18	106	2	PF00690
Domain	Cation_ATPase_N	ATP13A5 ATP2A2	4.60e-03	18	106	2	SM00831
Domain	CTCK_1	MUC2 MUC5AC	4.60e-03	18	106	2	PS01185
Domain	VWC_out	MUC2 MUC5AC	5.12e-03	19	106	2	SM00215
Domain	ATPase_P-typ_cation-transptr_N	ATP13A5 ATP2A2	5.12e-03	19	106	2	IPR004014
Pathway	REACTOME_RAS_PROCESSING	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.28e-15	45	83	11	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L20 USP17L11 USP24 PSMC1 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	7.95e-11	191	83	13	MM15289
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	HGF USP17L20 USP17L11 PSMC1 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P LRRC7 NRG3 USP17L22 USP17L15 USP17L13	4.37e-10	318	83	15	MM15278
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L20 USP17L11 USP17L24 USP24 PSMC1 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L15 USP17L13	4.88e-10	221	83	13	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L20 USP17L11 USP24 PSMC1 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	3.90e-09	262	83	13	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L20 USP17L11 USP17L24 USP24 PSMC1 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L15 USP17L13	1.90e-08	299	83	13	M27574
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	FBXW10 PCGF2 USP17L20 USP17L11 USP24 NUP98 PSMC1 USP17L5 USP17L10 USP17L19 DDB1 GFPT1 USP17L18 USP17L17 USP17L6P PRKDC USP17L22 MUC2 MUC5AC USP17L15 USP17L13 ALG13	1.16e-05	1389	83	22	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	FBXW10 PCGF2 ANK3 USP17L20 USP17L11 USP17L24 USP24 NUP98 PSMC1 USP17L5 USP17L10 USP17L19 DDB1 GFPT1 USP17L18 USP17L17 PRKDC USP17L22 MUC5AC USP17L15 USP17L13 ALG13	2.97e-05	1475	83	22	M19806
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L20 USP17L11 NUP98 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.22e-24	24	114	12	8995226
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.81e-23	21	114	11	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.81e-23	21	114	11	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.81e-23	21	114	11	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.81e-23	21	114	11	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.81e-23	21	114	11	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.81e-23	21	114	11	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.96e-22	22	114	11	9154835
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.84e-22	33	114	12	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	20403174
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	14699124
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	11941478
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	20388806
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	20368735
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.37e-22	34	114	12	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	6.64e-22	35	114	12	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	6.64e-22	35	114	12	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.93e-22	36	114	12	20147298
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.23e-21	25	114	11	21115691
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.47e-21	37	114	12	20228808
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.12e-21	26	114	11	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.41e-21	29	114	11	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	9.60e-18	50	114	11	31806660
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP24 NUP98 DDX51 NOL9 HUWE1 DDB1 PGAM5 GFPT1 HELZ2 BYSL PRKDC ATP2A2 SYMPK	2.45e-07	653	114	13	22586326
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 CT55 TLR2 USP17L6P USP17L22 USP17L15 USP17L13	3.50e-07	674	114	13	37196079
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	USP24 NUP98 PSMC1 HUWE1 DDB1 PGAM5 ADD3 MTHFD1 APPL1 PRKDC ATP2A2 SYMPK	1.32e-06	638	114	12	33239621
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	MRPS18B USP24 NUP98 PSMC1 HUWE1 DDB1 MTHFD1 PRKDC ATP2A2	2.13e-06	344	114	9	36282215
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ANK3 DSC3 USP24 PSMC1 DDB1 GFPT1 MTHFD1 EPHA2 BUB1B LRRC7 PRKDC ATP2A2	3.84e-06	708	114	12	39231216
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	EPM2A MRPS18B NUP98 PSMC1 NCSTN HUWE1 DDB1 PGAM5 POF1B GFPT1 PTPN9 EPHA2 PRKDC HNRNPLL	3.88e-06	974	114	14	28675297
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	HUWE1 DDB1 MTHFD1 PRKDC ATP2A2	4.07e-06	72	114	5	36376293
Pubmed	The DNA sequence of the human X chromosome.	CFAP47 FAM47B HUWE1 POF1B MBTPS2 PCDH19 CT55 SLC6A14 ALG13	8.28e-06	407	114	9	15772651
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	PSMC1 USP9Y DDB1 BRCA2 PRKDC	1.03e-05	87	114	5	17148452
Pubmed	Worm expulsion of Gymnophalloides seoi from C57BL/6 mice: role of metacercarial exosomes in upregulating TLR2 and MUC2 expression in intestinal tissues.	TLR2 MUC2	1.07e-05	2	114	2	30019213
Pubmed	Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage.	BRCA2 CT55	1.07e-05	2	114	2	18307534
Pubmed	Mucolytic activity of bacterial and human chitinases.	MUC2 MUC5AC	1.07e-05	2	114	2	17321686
Pubmed	Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.	MUC2 MUC5AC	1.07e-05	2	114	2	20731025
Pubmed	Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1.	BRCA2 BUB1B	1.07e-05	2	114	2	10749118
Pubmed	Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.	HGF PRKDC	1.07e-05	2	114	2	29928062
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.	MUC2 MUC5AC	1.07e-05	2	114	2	23832517
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.	MUC2 MUC5AC	1.07e-05	2	114	2	23832516
Pubmed	Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.	MUC2 MUC5AC	1.07e-05	2	114	2	17203232
Pubmed	Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.	MUC2 MUC5AC	1.07e-05	2	114	2	12527922
Pubmed	L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.	PRKDC MUC2	1.07e-05	2	114	2	36584066
Pubmed	In vivo glycosylation of mucin tandem repeats.	MUC2 MUC5AC	1.07e-05	2	114	2	11445551
Pubmed	WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly.	CFAP47 WDR87	1.07e-05	2	114	2	36571501
Pubmed	Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma.	MUC2 MUC5AC	1.07e-05	2	114	2	14594655
Pubmed	Abnormal subcellular distribution of mature MUC2 and de novo MUC5AC mucins in adenomas of the rectum: immunohistochemical detection using non-VNTR antibodies to MUC2 and MUC5AC peptide.	MUC2 MUC5AC	1.07e-05	2	114	2	12820724
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HECTD4 PLXND1 HUWE1 TXNRD2 TEP1 DUS1L ZCCHC14 C2CD3 UBN1 UCKL1 HELZ2 PRKDC PREX1 SYMPK	1.61e-05	1105	114	14	35748872
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PCGF2 ANK3 HECTD4 PSMC1 HUWE1 USP9Y GFPT1 ADD3 ASTN1 APPL1 PRKDC ATP2A2 GEN1 PREX1 DOP1B	2.04e-05	1285	114	15	35914814
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	PSMC1 HUWE1 DDB1 PGAM5 MTHFD1 PRKDC ATP2A2	2.27e-05	256	114	7	35777956
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	USP24 PSMC1 HUWE1 RNF17 DDB1 UBN1 BUB1B PRKDC HNRNPLL SYMPK	2.29e-05	582	114	10	20467437
Pubmed	The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.	MRPS18B PSMC1 HUWE1 DDB1 PGAM5 PRKDC	2.70e-05	177	114	6	26485645
Pubmed	Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.	TLR2 PRKDC	3.19e-05	3	114	2	17030581
Pubmed	P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease.	EPM2A PREX1	3.19e-05	3	114	2	36638890
Pubmed	Differences in the expression of mucins in various forms of cystitis glandularis.	MUC2 MUC5AC	3.19e-05	3	114	2	17659847
Pubmed	Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.	MUC2 MUC5AC	3.19e-05	3	114	2	18825309
Pubmed	Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.	BRCA2 BUB1B	3.19e-05	3	114	2	14646599
Pubmed	Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia.	MUC2 MUC5AC	3.19e-05	3	114	2	18300795
Pubmed	Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast.	MUC2 MUC5AC	3.19e-05	3	114	2	17333267
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC2 MUC5AC	3.19e-05	3	114	2	19718741
Pubmed	Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer.	PRKDC SPIDR	3.19e-05	3	114	2	23603433
Pubmed	IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.	TLR2 PRKDC	3.19e-05	3	114	2	21813778
Pubmed	HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.	HUWE1 PRKDC	3.19e-05	3	114	2	32457294
Pubmed	Gene expression profiling of colorectal mucinous adenocarcinomas.	MUC2 MUC5AC	3.19e-05	3	114	2	20485009
Pubmed	Clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC expression in japanese gastric carcinomas.	MUC2 MUC5AC	3.19e-05	3	114	2	23464473
Pubmed	Meconium ileus in cystic fibrosis is not linked to central repetitive region length variation in MUC1, MUC2, and MUC5AC.	MUC2 MUC5AC	3.19e-05	3	114	2	24920497
Pubmed	HELZ2 promotes K63-linked polyubiquitination of c-Myc to induce retinoblastoma tumorigenesis.	HUWE1 HELZ2	3.19e-05	3	114	2	34761308
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	PSMC1 DDB1 PGAM5 MTHFD1 BYSL PRKDC ATP2A2	3.34e-05	272	114	7	25315684
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	PSMC1 HUWE1 DDB1 PGAM5 WDR87 BYSL PRKDC	4.11e-05	281	114	7	30455355
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L20 USP17L11 USP17L19 USP17L18 USP17L17	4.70e-05	119	114	5	28625976
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	USP24 NUP98 DDX51 HUWE1 UBN1 HELZ2 APPL1 PRKDC ATP2A2 IQCK SYMPK	4.98e-05	774	114	11	15302935
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	DDX51 NCSTN NOL9 WDR76 MBTPS2 LRRC7 ATP2A2	5.70e-05	296	114	7	34186245
Pubmed	HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.	PSMC1 HUWE1	6.36e-05	4	114	2	23209776
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L15 USP17L13	6.36e-05	4	114	2	22984479
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC2 MUC5AC	6.36e-05	4	114	2	25638393
Pubmed	MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.	TLR2 PRKDC	6.36e-05	4	114	2	15265935
Pubmed	Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.	MUC2 MUC5AC	6.36e-05	4	114	2	22269464
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	MUC2 MUC5AC	6.36e-05	4	114	2	22691042
Pubmed	Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells.	MUC2 MUC5AC	6.36e-05	4	114	2	12391274
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC2 MUC5AC	6.36e-05	4	114	2	23807779
Pubmed	Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.	MUC2 MUC5AC	6.36e-05	4	114	2	33154304
Pubmed	Gastric mucin expression in first-degree relatives of gastric cancer patients.	MUC2 MUC5AC	6.36e-05	4	114	2	24901817
Pubmed	Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).	MUC2 MUC5AC	6.36e-05	4	114	2	36367122
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC2 MUC5AC	6.36e-05	4	114	2	17471237
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC2 MUC5AC	6.36e-05	4	114	2	14984930
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC2 MUC5AC	6.36e-05	4	114	2	29869461
Pubmed	[Expression and clinical significance of Mucin and E-cadherin in colorectal tumors].	MUC2 MUC5AC	6.36e-05	4	114	2	17991319
Pubmed	Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions?	MUC2 MUC5AC	6.36e-05	4	114	2	20929551
Pubmed	MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.	MUC2 MUC5AC	6.36e-05	4	114	2	27298226
Pubmed	PGE(2) induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation.	MUC2 MUC5AC	6.36e-05	4	114	2	23619266
Pubmed	Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.	EPM2A PRKDC	6.36e-05	4	114	2	24209604
Pubmed	Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus.	MUC2 MUC5AC	6.36e-05	4	114	2	17401217
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC2 MUC5AC	6.36e-05	4	114	2	12676567
Pubmed	Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours.	MUC2 MUC5AC	6.36e-05	4	114	2	25298197
Cytoband	4p16.1	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.35e-18	79	114	12	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.34e-13	222	114	12	chr4p16
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ASAP3 APPL1 ACAP2	2.65e-05	17	63	3	1291
GeneFamily	Plexins	PLXND1 PLXNB1	4.23e-04	9	63	2	683
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP3 APPL1 ACAP2 PREX1 PHLPP2	7.52e-04	206	63	5	682
GeneFamily	CD molecules\|Mucins	MUC2 MUC5AC	2.40e-03	21	63	2	648
GeneFamily	ArfGAPs	ASAP3 ACAP2	5.89e-03	33	63	2	395
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	C2CD3 CAPN5	6.98e-03	36	63	2	823
GeneFamily	Tudor domain containing	RNF17 ALG13	7.36e-03	37	63	2	780
Coexpression	MADAN_DPPA4_TARGETS	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 RNF17 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.13e-15	86	111	12	MM1312
Coexpression	GERY_CEBP_TARGETS	HGF ANK3 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.79e-13	160	111	13	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.74e-12	112	111	11	MM1095
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 TLR2 USP17L6P USP17L22 USP17L15 DOP1B USP17L13	3.67e-06	647	111	13	MM981
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	CEP104 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 UBN1 USP17L17 EPHA2 TLR2 HELZ2 USP17L6P USP17L22 USP17L15 DOP1B USP17L13	1.56e-05	1226	111	17	MM979
Coexpression	GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_BCELL_DN	SLCO3A1 WDR76 UCKL1 HELZ2 NEIL3 PRKDC DOP1B	2.36e-05	200	111	7	M6745
Coexpression	BRUINS_UVC_RESPONSE_LATE	DONSON USP17L20 USP17L11 PSMC1 SLCO3A1 USP17L5 USP17L10 USP17L19 USP17L18 SRRD ABCG1 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.48e-05	1198	111	16	MM1062
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDR76 BRCA2 TLR2 BUB1B NEIL3 PREX1	6.07e-06	187	107	6	73931a5ea73799095daff100b5f18853c57c74dc
ToppCell	Control_saline-Endothelial-Endothelial-FOXM1\|Control_saline / Treatment groups by lineage, cell group, cell type	ATP13A5 WDR76 BRCA2 BUB1B NEIL3 GEN1	8.91e-06	200	107	6	9bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FBXW10 ATP13A5 CCDC168 EPHA2 KCNJ8	2.02e-05	137	107	5	9324b55eac55e0cc1e8e450a4b5374d12e9587a3
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Kcnj8_(Mural.Acta2Rgs5.Kcnj8)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FBXW10 ATP13A5 CCDC168 EPHA2 KCNJ8	2.02e-05	137	107	5	032f8409d0d179e254c8ff632afbda78852a9889
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Kcnj8_(Mural.Acta2Rgs5.Kcnj8)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FBXW10 ATP13A5 CCDC168 EPHA2 KCNJ8	2.02e-05	137	107	5	265a4a50e48b13c8b3b0730f818235f71fbd6baa
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	DSC3 ATP13A5 ASXL3 EPHA2 BUB1B	3.53e-05	154	107	5	38d346402417960044ae999e61f0092b46f2b591
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXND1 WDR76 BRCA2 BUB1B NEIL3	3.64e-05	155	107	5	969fc4c98a96bf2f436e8e63d4deb2183ef3b864
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GOLGA6L6 WDR76 BRCA2 BUB1B NEIL3	5.50e-05	169	107	5	54b13ab02b4c187f4754045ecfcf409749e7ccc0
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPM2A DSC3 KCNU1 N6AMT1 NEIL3	5.65e-05	170	107	5	45de83a2231208b8e1f21061d0b91644b4a3ba93
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 RARRES1 SLCO3A1 ABCG1 EPHA2	6.14e-05	173	107	5	0f9c1d3298e59e6d22bb3306f0f445f490be8bbd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLFN14 WDR76 BRCA2 BUB1B NEIL3	6.14e-05	173	107	5	a25459b8140b0dbcb73e3b4cc1407b679229f25c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDR76 BRCA2 BUB1B NEIL3 PRKDC	7.22e-05	179	107	5	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PLXND1 ABCG1 HELZ2 NRG3 PREX1	7.41e-05	180	107	5	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WDR76 BRCA2 BUB1B NEIL3 GEN1	7.41e-05	180	107	5	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	Dividing_Macrophages-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	WDR76 BRCA2 BUB1B NEIL3 GEN1	8.22e-05	184	107	5	f15ce786d25c6546804a6d1efcc2ad645f2ef54e
ToppCell	Control-T_cells-Cycling_NK/T_cells\|Control / group, cell type (main and fine annotations)	WDR76 BRCA2 BUB1B NEIL3 GEN1	8.43e-05	185	107	5	9766216b41ee62bbac4caa25cb98ec5627a24075
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDR76 BRCA2 BUB1B NEIL3 GEN1	8.43e-05	185	107	5	30e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell	COVID-CD4-CD8_1\|COVID / Condition, Cell_class and T cell subcluster	DONSON WDR76 FCRL6 BUB1B HERC3	8.43e-05	185	107	5	c634bb04a081ae3214b68f6e4a147db5b2b916ed
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDR76 BRCA2 BUB1B NEIL3 GEN1	8.87e-05	187	107	5	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WDR76 BRCA2 BUB1B NEIL3 GEN1	9.32e-05	189	107	5	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	WDR76 BRCA2 BUB1B NEIL3 LRRC7	9.56e-05	190	107	5	e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	BRCA2 TLR2 BUB1B SPIDR PREX1	1.00e-04	192	107	5	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	WDR76 SRRD PTPN9 MTHFD1 PCDH19	1.03e-04	193	107	5	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-Cycling_T\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IL36A WDR76 BRCA2 BUB1B NEIL3	1.03e-04	193	107	5	81e6240cffb094b2aa3684fd0889b6497f47c4f0
ToppCell	Control-Lymphocyte-T_NK-T_NK_proliferative\|Control / Disease, Lineage and Cell Type	DONSON WDR76 BRCA2 BUB1B NEIL3	1.05e-04	194	107	5	844731b7943d1cfca819b7b89e4e62067bfa0230
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DONSON WDR76 BRCA2 MTHFD1 BUB1B	1.05e-04	194	107	5	4c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|World / disease group, cell group and cell class (v2)	ANK3 MTERF4 ABCG1 OXNAD1 HNRNPLL	1.08e-04	195	107	5	a72bb5b1b15dd1ab70ced5622d94499caff8bb6b
ToppCell	Goblet_1\|World / shred by cell class for nasal brushing	RARRES1 GFPT1 CAPN5 MUC5AC SLC6A14	1.08e-04	195	107	5	d9e4889a2e7b7c97c07c15b043b77837739462e4
ToppCell	proximal-Hematologic-Proliferating_Macrophage\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DONSON WDR76 BRCA2 BUB1B NEIL3	1.13e-04	197	107	5	0b1fa881abbfcc54b322fc27124db3f8947af016
ToppCell	5'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RARRES1 DUS1L CAPN5 ATP2A2 PLXNB1	1.13e-04	197	107	5	e14a0e8a893c72356afc5508e3531ae0b23bfe16
ToppCell	proximal-3-Hematologic-Proliferating_Macrophage\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DONSON WDR76 BRCA2 BUB1B NEIL3	1.13e-04	197	107	5	0dd9058aa19d1268ebba9a65555870224b5a5978
ToppCell	5'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RARRES1 DUS1L CAPN5 ATP2A2 PLXNB1	1.13e-04	197	107	5	19cf283537c853fa902852e7b8ac1139729a931a
ToppCell	proximal-Hematologic-Proliferating_Macrophage-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DONSON WDR76 BRCA2 BUB1B NEIL3	1.13e-04	197	107	5	9243617b307acf3df40d93c41cd8d4788699a7ea
ToppCell	distal-1-Hematologic-Proliferating_Macrophage\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DONSON WDR76 BRCA2 BUB1B NEIL3	1.16e-04	198	107	5	df3f5559ecd1f3cd1fd60e39dbad8741309e83a3
ToppCell	distal-Hematologic-Proliferating_Macrophage-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DONSON WDR76 BRCA2 BUB1B NEIL3	1.16e-04	198	107	5	2b0716e900bce54ad1825d6dcdaf4ebf31f355c4
ToppCell	5'-Adult-Distal_Rectal-Epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RARRES1 GFPT1 DUS1L CAPN5 PLXNB1	1.16e-04	198	107	5	9c0535099750698daac5d6b4d39fb19fecf4ffde
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DSC3 BRCA2 BUB1B NEIL3 GEN1	1.16e-04	198	107	5	f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell	cycling_basal_cell\|World / shred by cell class for turbinate	WDR76 BRCA2 MTHFD1 BUB1B NEIL3	1.16e-04	198	107	5	e86c1224f5b0890a50a25257628e90c790aae7cd
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	DONSON WDR76 BRCA2 BUB1B NEIL3	1.19e-04	199	107	5	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WDR76 BRCA2 BUB1B NEIL3 NRG3	1.19e-04	199	107	5	1d5a3366474c17e3df0ba5cf11b586655529e9bd
ToppCell	mild_COVID-19-T/NK_proliferative\|mild_COVID-19 / disease group, cell group and cell class (v2)	DONSON WDR76 BRCA2 MTHFD1 BUB1B	1.19e-04	199	107	5	df2fcaf01b1b48632f84e7355ef21d20853f0664
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	WDR76 BRCA2 BUB1B NEIL3 GEN1	1.22e-04	200	107	5	8f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	WDR76 BRCA2 BUB1B NEIL3 GEN1	1.22e-04	200	107	5	4cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells\|10w / Sample Type, Dataset, Time_group, and Cell type.	WDR76 BRCA2 BUB1B NEIL3 GEN1	1.22e-04	200	107	5	a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCell	356C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	DONSON WDR76 BRCA2 MTHFD1 NEIL3	1.22e-04	200	107	5	97e47eb69d1d4cab45256acca9589837eb7817e7
ToppCell	Biopsy_Control_(H.)-Immune-Proliferating_Macrophages\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	WDR76 BRCA2 BUB1B NEIL3 GEN1	1.22e-04	200	107	5	ce9fad55f779afd3d6c5a9c5a15e2d9f548b7c7e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DONSON WDR76 BRCA2 BUB1B NEIL3	1.22e-04	200	107	5	28c702449040ac15fe4e0c6340bb6f137e88539d
ToppCell	Bronchus_Control_(B.)-Epithelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	RARRES1 ANK3 EPHA2 MUC5AC SLC6A14	1.22e-04	200	107	5	f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	ANK3 USP9Y ADD3 HELZ2 OXNAD1	1.22e-04	200	107	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	PSB-critical-LOC-Lymphoid-Treg\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DSC3 WDR76 BRCA2 BUB1B NEIL3	1.22e-04	200	107	5	3e3de496508efb2f95e5e8684f97687381e96493
ToppCell	356C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DONSON WDR76 BRCA2 MTHFD1 NEIL3	1.22e-04	200	107	5	5d11a2c0021805e78d97dc1638bf73ca1faede66
ToppCell	LAM-Myeloid-pMacrophage\|LAM / Condition, Lineage and Cell class	DONSON WDR76 BRCA2 BUB1B NEIL3	1.22e-04	200	107	5	7e233d037165c9d3607604aaaf0f368e266567d3
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	USP24 HUWE1 USP9Y FCRL6 ADD3	1.22e-04	200	107	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WDR76 BRCA2 BUB1B NEIL3 GEN1	1.22e-04	200	107	5	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	Calu_3\|World / Cell line, Condition and Strain	RARRES1 SLCO3A1 HELZ2 MUC5AC PLXNB1	1.22e-04	200	107	5	a549aa08aeefe905653266dae3936094ff55f8e4
Drug	Clotrimazole [23593-75-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A	EPM2A PCGF2 WDR76 ZCCHC14 ABCG1 MBTPS2 EPHA2 MUC5AC	2.47e-06	194	101	8	3166_DN
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.36e-19	46	110	12	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.87e-17	69	110	12	DOID:1682 (implicated_via_orthology)
Disease	cystitis (is_marker_for)	MUC2 MUC5AC	1.38e-05	2	110	2	DOID:1679 (is_marker_for)
Disease	keratoconjunctivitis (is_marker_for)	TLR2 MUC5AC	4.12e-05	3	110	2	DOID:9368 (is_marker_for)
Disease	sputum mucin-5B amount	MUC2 MUC5AC	4.12e-05	3	110	2	OBA_2050332
Disease	mucinous adenocarcinoma (is_marker_for)	MUC2 MUC5AC	1.37e-04	5	110	2	DOID:3030 (is_marker_for)
Disease	response to iloperidone	SLCO3A1 NRG3	2.05e-04	6	110	2	GO_0036287
Disease	biliary tract benign neoplasm (is_marker_for)	HGF MUC5AC	2.86e-04	7	110	2	DOID:0050625 (is_marker_for)
Disease	bringing up phlegm, sputum or mucus on most days, self-reported	MUC2 MUC5AC	4.87e-04	9	110	2	EFO_0009824
Disease	dry eye syndrome (is_marker_for)	TLR2 MUC5AC	6.08e-04	10	110	2	DOID:10140 (is_marker_for)
Disease	cholesteatoma (is_marker_for)	HGF TLR2	6.08e-04	10	110	2	DOID:869 (is_marker_for)
Disease	pneumonia	HELZ2 MUC2 MUC5AC	7.25e-04	47	110	3	EFO_0003106
Disease	Epilepsy	ASXL3 PCDH19 ASTN1 ALG13	7.53e-04	109	110	4	C0014544
Disease	factor VII activating protease measurement	HELZ2 DCLRE1A NRG3	1.15e-03	55	110	3	EFO_0009368
Disease	cystic fibrosis associated meconium ileus	PRSS58 SLC6A14	1.22e-03	14	110	2	EFO_0004608
Disease	pancreatitis	HECTD4 PRSS58	1.60e-03	16	110	2	EFO_0000278
Disease	cholangiocarcinoma (is_marker_for)	HGF MUC2 MUC5AC	1.78e-03	64	110	3	DOID:4947 (is_marker_for)
Disease	dermatomyositis (is_marker_for)	HGF TLR2	1.81e-03	17	110	2	DOID:10223 (is_marker_for)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR2 MUC2	1.81e-03	17	110	2	DOID:8677 (biomarker_via_orthology)
Disease	interstitial lung disease	FCRL6 NRG3 MUC5AC	2.03e-03	67	110	3	EFO_0004244
Disease	schizophrenia (implicated_via_orthology)	NCSTN ASTN1 NRG3	2.12e-03	68	110	3	DOID:5419 (implicated_via_orthology)
Disease	vitiligo (is_implicated_in)	HGF TLR2	2.76e-03	21	110	2	DOID:12306 (is_implicated_in)
Disease	spermatogenic failure (is_implicated_in)	KCNU1 CT55	3.31e-03	23	110	2	DOID:0111910 (is_implicated_in)
Disease	Disease Exacerbation	MRPS18B DDB1 EPHA2 SYMPK	3.44e-03	165	110	4	C0235874
Disease	Epilepsy, Cryptogenic	ASXL3 PCDH19 ALG13	3.60e-03	82	110	3	C0086237
Disease	Awakening Epilepsy	ASXL3 PCDH19 ALG13	3.60e-03	82	110	3	C0751111
Disease	Aura	ASXL3 PCDH19 ALG13	3.60e-03	82	110	3	C0236018

Protein segments in the cluster

Peptide	Gene	Start	Entry
CKIEPSINHILSTRK	BUB1B	356	O60566
ILLSRTHCSVTLKPA	CFAP54	911	Q96N23
CLTISHSTINRPPVK	ASAP3	331	Q8TDY4
KTTNIQCVPHLIREG	ATP13A5	881	Q4VNC0
KQALVTATHPTCTLL	ALG13	171	Q9NP73
GRSIICTIHQPSAKL	ABCG1	266	P45844
STRPDVKCVIHIHTL	ADD3	221	Q9UEY8
LSKCNIQVHSPRESV	FBXW10	716	Q5XX13
AHEKLSVPVTCKIRV	DUS1L	136	Q6P1R4
DIIKCRVINTSHLSI	CAPN5	336	O15484
PTVVVEDLRLCTVKH	ACAP2	306	Q15057
SSHVNCPLVVKITLH	ASTN1	401	O14525
NRSIPCKVIVDHSTT	ASXL3	1466	Q9C0F0
QIPSHIVRLKPSCST	IQCK	6	Q8N0W5
RLNVCVSKQHSVVPS	HNRNPLL	401	Q8WVV9
ILKTSEVTQHLPREC	PTPN9	216	P43378
KTAPCVRLLNATHQI	NCSTN	46	Q92542
CQGIEVRKTISHLPI	NRG3	526	P56975
IPAHCKVTVSVLDTN	PCDH19	326	Q8TAB3
SPQCSIVLLEHLKTA	NOL9	216	Q5SY16
ATSVKPIRCIHTEEV	CT55	166	Q8WUE5
DSTLIQLSIHCPKLQ	FBXL2	301	Q9UKC9
LEQLHIKVTSLCSRI	NUP98	1716	P52948
LGSCPRQVEHVTIKL	EPM2A	166	O95278
LVAPLIICHVIDKRS	KCNJ8	261	Q15842
HVDICKLPTRNTIIS	NEIL3	286	Q8TAT5
QIHCRPESSKGVISI	LRRC7	911	Q96NW7
ESPCHVKLLRTQKVV	HERC3	231	Q15034
LLLLQPKTQRTSIHC	DOP1B	1001	Q9Y3R5
CLKLIDPQTQVTRLT	APPL1	551	Q9UKG1
SLVTLRCQTKLHPLR	FCRL6	126	Q6DN72
TVALVPCLTKHVLRE	PLXNB1	1846	O43157
HIGREPTLCKVLNST	PLXND1	1106	Q9Y4D7
RHKALPTCISHIIVV	OR4A16	231	Q8NH70
QIRLIGQSCTAPKIH	MUC2	751	Q02817
TTDIISRHLPGVCKV	PGAM5	156	Q96HS1
HLRPEPSKTQVSSLC	FAM47B	306	Q8NA70
RKSVHQICSGPVVLS	PMS2P11	166	Q13670
QVHTIRILTCQKTEL	GOLGA6L6	116	A8MZA4
CKSRSRQHITVPSVK	KCNU1	621	A8MYU2
TRLQCRAKSHPEVSI	MUC5AC	2161	P98088
TIVNLDHPVISCAKT	HGF	476	P14210
VCQRLGVSHIITEPK	HECTD4	201	Q9Y4D8
LSITTKDPRILVTHC	GARIN1B	201	Q96KD3
HLERTPKLSSIIDCT	HUWE1	336	Q7Z6Z7
LKISTCAPSTLHITQ	POF1B	101	Q8WVV4
CDVQVHKTRPLLSIR	PCGF2	56	P35227
PEKIACSLHVTKQTT	OXNAD1	236	Q96HP4
TLRHRVVLVNCEPSK	PAPPA2	576	Q9BXP8
IDRCTHIRVGSTKVP	ATP2A2	521	P16615
ETAHCVERTIPVLLT	CEP104	521	O60308
PVTIALISCRHVETL	IL36A	41	Q9UHA7
PQIRTVAKSHSDSCI	C2CD3	291	Q4AC94
TKLLRVNLCECTHPT	DSC3	661	Q14574
LQCTHVTPQRDKSVV	BRCA2	146	P51587
CSLSSKPLVVLHLVL	DDX51	486	Q8N8A6
VLKFTTEIHPSCVTR	EPHA2	601	P29317
TEIHPSCVTRQKVIG	EPHA2	606	P29317
HTRAQPVICSKLLLT	ADGRF2	26	Q8IZF7
CVDVKSRIPVKNTHR	ANK3	3906	Q12955
CIIPSLETHTRLIKV	MBTPS2	386	O43462
LVQHCRATEVTLPKS	DONSON	186	Q9NYP3
LQHTTLKPPDVTCIS	IL22RA1	116	Q8N6P7
SSPKIHIKETEQCVR	GEN1	841	Q17RS7
LCRTQKSQHVSPKIR	DCLRE1A	101	Q6PJP8
QKEVCLPITLHSLSA	CCDC168	3531	Q8NDH2
VIRRPETKVLICTHT	HELZ2	561	Q9BYK8
PLRSHITLKIECVTE	CFAP47	3006	Q6ZTR5
CPHVVVLVATVRALK	MTHFD1	691	P11586
IITKCSIPVLHSSAA	BYSL	311	Q13895
PIIKQSTIVCHNRVD	DDB1	251	Q16531
SSVVRRCIHKPTSQE	PHKG1	31	Q16816
VCIIPRLIHLSSTQS	SLFN14	506	P0C7P3
VITAAHCNLPKLRVI	PRSS58	51	Q8IYP2
VTKHLLSNPVFTCII	SLCO3A1	341	Q9UIG8
RTIKVPHSVDCLQGI	GFPT1	651	Q06210
QVTKILHSCPSVLRE	MTERF4	211	Q7Z6M4
STLCRHKIIHTQEKP	FEZF1	301	A0PJY2
VLLHCQSLLSPATVK	PREX1	1376	Q8TCU6
KHRTLPKSVVDVCRV	HERC2P3	196	Q9BVR0
ASKLPLVTPHTQCRL	PSMC1	46	P62191
TAKLTLNRLCQIPSH	RNF17	1521	Q9BXT8
GSHRVQVPLQTLCTK	MRPS18B	21	Q9Y676
IPLVVKSVHCATVLS	ZSWIM5	1061	Q9P217
KLPRCVHLVLSVSSD	TEP1	1286	Q99973
KTIPTTIANCKRLHT	PHLPP2	681	Q6ZVD8
HLELCPRPKQETTTS	SPIDR	76	Q14159
VCLQRAPASKTLTLH	USP17L18	256	D6R9N7
VKPQSCIDIVIRHVA	MOSPD3	86	O75425
VCLQRAPASKTLTLH	USP17L5	256	A8MUK1
VCLQRAPASKTLTLH	USP17L13	256	C9JLJ4
SIPREILVTGTCHLK	SRRD	126	Q9UH36
VCLQRAPASKTLTLH	USP17L19	256	D6RCP7
IKTRGQHVTLRCSPI	TRBV5-7	31	A0A0A0MS05
LLLHCPSKTVRQLAQ	USP9Y	1321	O00507
VTRCLHSLTDKVPPS	SYMPK	856	Q92797
TVVHQGLIRICSKPV	PRKDC	481	P78527
CHKITPRTEAPVSSV	ZCCHC14	51	Q8WYQ9
SCISSKIPLLTTIRH	WDR76	526	Q9H967
IHPTCSEEVVKLRIS	TXNRD2	496	Q9NNW7
RTCIKSLPSVLVIHL	USP24	1871	Q9UPU5
KASPTQCHRSLLQLV	UBN1	831	Q9NPG3
VCLQRAPASKTLTLH	USP17L24	256	Q0WX57
QCHPLPRTLSVLKST	UCKL1	316	Q9NWZ5
VCLQRAPASKTLTLH	USP17L6P	256	Q6QN14
VCLQRAPASKTLTLH	USP17L22	256	D6RA61
RSPIVTHCNVSTVNK	SLC6A14	166	Q9UN76
TVLLHELSTQEIIPC	RARRES1	236	P49788
TRIHSVTGCIPKTLE	TLR2	446	O60603
VCLQRAPASKTLTLH	USP17L15	256	C9J2P7
VCLQRAPASKTLTLH	USP17L17	256	D6RBQ6
LLSCSRKLHNLPTQV	UHRF1BP1	491	Q6BDS2
KVQLRPLASILSSCH	WDR87	506	Q6ZQQ6
VCLQRAPASKTLTLH	USP17L20	256	D6RJB6
VCLQRAPASKTLTLH	USP17L10	256	C9JJH3
VCLQRAPASKTLTLH	USP17L11	256	C9JVI0
TLETARCNKVHIQPV	N6AMT1	86	Q9Y5N5