Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	methyltransferase complex	SETD1A SETD1B PHF19 ZC3H13 ZNF335 TAF1	9.31e-06	108	94	6	GO:0034708
GeneOntologyCellularComponent	histone methyltransferase complex	SETD1A SETD1B PHF19 ZNF335 TAF1	2.22e-05	75	94	5	GO:0035097
GeneOntologyCellularComponent	inhibitory synapse	GPHN RIMS1 BSN	3.61e-04	31	94	3	GO:0060077
GeneOntologyCellularComponent	cytoskeleton of presynaptic active zone	RIMS1 BSN	5.50e-04	8	94	2	GO:0048788
Domain	N-SET	SETD1A SETD1B	2.35e-05	2	91	2	PF11764
Domain	COMPASS_Set1_N-SET	SETD1A SETD1B	2.35e-05	2	91	2	IPR024657
Domain	DVL-1	DVL1P1 DVL1	2.35e-05	2	91	2	IPR008340
Domain	N-SET	SETD1A SETD1B	2.35e-05	2	91	2	SM01291
Domain	PDZ	IL16 DVL1P1 FRMPD1 DVL1 RIMS1 PDZD2	6.55e-05	141	91	6	PF00595
Domain	PDZ	IL16 DVL1P1 FRMPD1 DVL1 RIMS1 PDZD2	8.57e-05	148	91	6	SM00228
Domain	PDZ	IL16 DVL1P1 FRMPD1 DVL1 RIMS1 PDZD2	9.57e-05	151	91	6	PS50106
Domain	PDZ	IL16 DVL1P1 FRMPD1 DVL1 RIMS1 PDZD2	9.93e-05	152	91	6	IPR001478
Domain	Dishevelled_fam	DVL1P1 DVL1	1.40e-04	4	91	2	IPR008339
Domain	Dishevelled	DVL1P1 DVL1	1.40e-04	4	91	2	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	1.40e-04	4	91	2	IPR003351
Domain	DEP	PIKFYVE DVL1P1 DVL1	1.61e-04	22	91	3	PF00610
Domain	DEP	PIKFYVE DVL1P1 DVL1	1.61e-04	22	91	3	PS50186
Domain	DEP	PIKFYVE DVL1P1 DVL1	1.61e-04	22	91	3	SM00049
Domain	DEP_dom	PIKFYVE DVL1P1 DVL1	1.85e-04	23	91	3	IPR000591
Domain	LisH	TCOF1 WDR26 TBL1X	3.36e-04	28	91	3	SM00667
Domain	LisH	TCOF1 WDR26 TBL1X	3.36e-04	28	91	3	IPR006594
Domain	LISH	TCOF1 WDR26 TBL1X	3.36e-04	28	91	3	PS50896
Domain	WD40_repeat	KIF21B EML4 VPS8 LRBA WDR26 TBL1X BRWD1	3.67e-04	272	91	7	IPR001680
Domain	WD_REPEATS_1	KIF21B EML4 VPS8 LRBA WDR26 TBL1X BRWD1	4.19e-04	278	91	7	PS00678
Domain	WD_REPEATS_2	KIF21B EML4 VPS8 LRBA WDR26 TBL1X BRWD1	4.28e-04	279	91	7	PS50082
Domain	WD_REPEATS_REGION	KIF21B EML4 VPS8 LRBA WDR26 TBL1X BRWD1	4.28e-04	279	91	7	PS50294
Domain	DIX	DVL1P1 DVL1	4.85e-04	7	91	2	PF00778
Domain	DIX	DVL1P1 DVL1	4.85e-04	7	91	2	IPR001158
Domain	DIX	DVL1P1 DVL1	4.85e-04	7	91	2	PS50841
Domain	DAX	DVL1P1 DVL1	4.85e-04	7	91	2	SM00021
Domain	WD40_repeat_dom	KIF21B EML4 VPS8 LRBA WDR26 TBL1X BRWD1	6.20e-04	297	91	7	IPR017986
Domain	-	IL16 FRMPD1 DVL1 RIMS1 PDZD2	8.35e-04	150	91	5	2.30.42.10
Domain	-	RGPD2 GCC1	1.03e-03	10	91	2	1.10.220.60
Domain	-	KIF21B EML4 VPS8 LRBA WDR26 TBL1X BRWD1	1.21e-03	333	91	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	KIF21B EML4 VPS8 LRBA WDR26 TBL1X BRWD1	1.25e-03	335	91	7	IPR015943
Domain	Grip	RGPD2 GCC1	1.25e-03	11	91	2	SM00755
Domain	GRIP	RGPD2 GCC1	1.25e-03	11	91	2	PF01465
Domain	GRIP_dom	RGPD2 GCC1	1.50e-03	12	91	2	IPR000237
Domain	GRIP	RGPD2 GCC1	1.50e-03	12	91	2	PS50913
Domain	WD40	KIF21B EML4 LRBA WDR26 TBL1X BRWD1	1.67e-03	259	91	6	PF00400
Domain	BTB	KCNG2 ZBTB46 BTBD7 ZBTB21 SLX4	1.87e-03	180	91	5	SM00225
Domain	WD40	KIF21B EML4 LRBA WDR26 TBL1X BRWD1	1.99e-03	268	91	6	SM00320
Domain	SEA	MUC17 MUC16	2.06e-03	14	91	2	SM00200
Domain	BTB/POZ_dom	KCNG2 ZBTB46 BTBD7 ZBTB21 SLX4	2.11e-03	185	91	5	IPR000210
Domain	Quinoprotein_ADH-like_supfam	EML4 VPS8 TBL1X	2.20e-03	53	91	3	IPR011047
Domain	SKP1/BTB/POZ	KCNG2 ZBTB46 BTBD7 ZBTB21 SLX4	2.32e-03	189	91	5	IPR011333
Domain	-	MUC17 MUC16	2.37e-03	15	91	2	3.30.70.960
Domain	N2O_reductase_N	VPS8 TBL1X	2.37e-03	15	91	2	IPR011045
Domain	Post-SET_dom	SETD1A SETD1B	2.70e-03	16	91	2	IPR003616
Domain	PostSET	SETD1A SETD1B	2.70e-03	16	91	2	SM00508
Domain	POST_SET	SETD1A SETD1B	2.70e-03	16	91	2	PS50868
Domain	BTB	ZBTB46 BTBD7 ZBTB21 SLX4	3.86e-03	131	91	4	PF00651
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC17 MUC16 MUC20	4.57e-05	16	63	3	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC17 MUC16 MUC20	5.53e-05	17	63	3	M27412
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC17 MUC16 MUC20	1.07e-04	21	63	3	MM15706
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC17 MUC16 MUC20	1.41e-04	23	63	3	M556
Pathway	REACTOME_DECTIN_2_FAMILY	MUC17 MUC16 MUC20	2.06e-04	26	63	3	M27483
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR RPAP1 TCOF1 EML4 ZC3H13 ZNF335 ZBTB21 FNBP4 KDM3B CDK11A AFF1 ZC3H18 RIMS1 SNAI1 THOC2	3.02e-09	774	95	15	15302935
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	GPHN TPR USP14 SETD1A TCOF1 SEC24B DVL1 FNBP4 KDM3B TAF1 LRBA THOC2 SNX9	3.52e-09	549	95	13	38280479
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PIKFYVE SETD1B TCOF1 PPP4R2 CDK11A MACF1 ZC3H18 CNTLN BSN SNX9 FAM135A GARRE1 SLX4	7.96e-09	588	95	13	38580884
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SAMD1 IL16 ZFHX4 TCOF1 BICRA SCN5A ZBTB21 KIAA1549 MACF1 ZC3H18 TAF1 SOWAHC WDR26 GARRE1 DNTTIP2 PTCD3 BRWD1	8.74e-09	1116	95	17	31753913
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	GPHN TPR USP14 GTF2E1 TCOF1 SEC24B ZBTB21 KDM3B MACF1 LRBA THOC2 SNX9 MARCKS DNTTIP2 NOL8	3.64e-08	934	95	15	33916271
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	TPR USP14 GTF2E1 CDK11A ZC3H18 TAF1 THOC2 DNTTIP2 NOL8	8.78e-08	283	95	9	30585729
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 KIF21B SETD1A ZBTB21 FNBP4 KDM3B KIAA1549 NFASC BSN NACAD GARRE1	2.25e-07	529	95	11	14621295
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TPR RGPD2 SAMD1 ZFHX4 ZBTB21 DVL1 TAF1 LRBA WDR26 TBL1X	2.30e-07	418	95	10	34709266
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AKAP6 TPR STARD8 NKAPD1 PPP4R2 ZC3H13 FRMPD1 AFF1 MACF1 TMEM131 THOC2 FAM135A SLX4 DNTTIP2 BRWD1	2.49e-07	1084	95	15	11544199
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	AKAP6 SETD1A RIMS1 NACAD GARRE1 PDZD2	4.33e-07	104	95	6	9205841
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE SETD1A SETD1B SPRED2 RPAP1 BICRA BTBD7 ZNF335 SCN5A DVL1 KDM3B LRBA AHDC1 MXD4	1.84e-06	1105	95	14	35748872
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TPR EML4 BICRA ZC3H13 FNBP4 CDK11A ZC3H18 TAF1 THOC2 SLX4 DNTTIP2 TASOR2 NOL8	2.01e-06	954	95	13	36373674
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	GPHN EML4 DVL1 MACF1	3.22e-06	37	95	4	27565344
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	GPHN RGPD2 PTPRZ1 MACF1 RIMS1 BSN BRWD1	3.50e-06	231	95	7	16452087
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	AKAP6 BICRA SEC24B NFASC RIMS1 LRBA MYO18B THOC2	3.50e-06	329	95	8	17474147
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PWWP2A SAMD1 GTF2E1 NKAPD1 ZBTB21 KDM3B ZC3H18 TAF1 DNTTIP2 BRWD1	6.60e-06	608	95	10	36089195
Pubmed	The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.	SETD1A SETD1B	7.38e-06	2	95	2	24550110
Pubmed	In Vivo and In Vitro Characterization of the RNA Binding Capacity of SETD1A (KMT2F).	SETD1A SETD1B	7.38e-06	2	95	2	38003223
Pubmed	Deubiquitylation and stabilization of Acf7 by ubiquitin carboxylterminal hydrolase 14 (USP14) is critical for NSCLC migration.	USP14 MACF1	7.38e-06	2	95	2	33737492
Pubmed	The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R.	IFIH1 EIF2AK2	7.38e-06	2	95	2	21123378
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	7.38e-06	2	95	2	8644734
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	SEC24B DVL1 KIAA1549 MACF1 TMEM131 LRBA FAM135A	8.18e-06	263	95	7	34702444
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	PWWP2A SETD1A SAMD1 SETD1B PHF19 EML4 SOWAHC AHDC1 MXD4	8.87e-06	495	95	9	27705803
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TCOF1 SEC24B KDM3B MUC16 GCC1 LRBA FAM135A MARCKS TASOR2 NOL8 PTCD3	9.17e-06	777	95	11	35844135
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PIKFYVE COBLL1 FRMPD1 FNBP4 PHLPP2	9.24e-06	102	95	5	10231032
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	GPHN TPR TCOF1 ZC3H13 COBLL1 TMEM131 THOC2 SOWAHC GLCCI1	1.01e-05	503	95	9	16964243
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PIKFYVE GPHN SEC24B VPS8 TMEM131 GCC1 LRBA FAM135A SNX19	1.02e-05	504	95	9	34432599
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	USP14 ZBTB46 BICRA FRMPD1 FNBP4 NFASC AFF1 MACF1 RIMS1 LRBA SNX9 AHDC1 TASOR2 TBL1X PDZD2	1.22e-05	1489	95	15	28611215
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPR TCOF1 ZC3H13 MACF1 ZC3H18 THOC2 SNX9 DNTTIP2 TASOR2 PTCD3	1.23e-05	653	95	10	22586326
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	GPHN KIF21B TPR RGPD2 TCOF1 ZBTB21 NFASC MACF1 RIMS1 BSN WDR26 TBL1X	1.26e-05	963	95	12	28671696
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	PIKFYVE VPS8 AFF1 BLOC1S3 GCC1 LRBA FAM135A	1.38e-05	285	95	7	34369648
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC17 MUC16 MUC20	1.56e-05	18	95	3	18834073
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETD1B RPAP1 BTBD7 VPS8 FRMPD1 MACF1 SNX19 PDZD2	1.64e-05	407	95	8	12693553
Pubmed	New nomenclature for chromatin-modifying enzymes.	SETD1A SETD1B KDM3B TAF1	1.85e-05	57	95	4	18022353
Pubmed	WDR82, a key epigenetics-related factor, plays a crucial role in normal early embryonic development in mice.	SETD1A SETD1B	2.21e-05	3	95	2	21123813
Pubmed	Role of RIG-I, MDA-5, and PKR on the expression of inflammatory chemokines induced by synthetic dsRNA in airway epithelial cells.	IFIH1 EIF2AK2	2.21e-05	3	95	2	17541283
Pubmed	Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.	PIKFYVE MTMR2	2.21e-05	3	95	2	22028665
Pubmed	Molecular insight into the SETD1A/B N-terminal region and its interaction with WDR82.	SETD1A SETD1B	2.21e-05	3	95	2	37030068
Pubmed	Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.	MUC16 MUC20	2.21e-05	3	95	2	30236127
Pubmed	Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.	MUC16 MUC20	2.21e-05	3	95	2	26770020
Pubmed	ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.	IFIH1 EIF2AK2	2.21e-05	3	95	2	37797622
Pubmed	The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.	SETD1A SETD1B	2.21e-05	3	95	2	33567280
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GPHN TPR SAMD1 ZFHX4 FRMPD1 ZBTB21 NPAS3 CDK11A SNX9 MXD4 TBL1X	2.27e-05	857	95	11	25609649
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TPR TCOF1 COBLL1 SEC24B MACF1 ZC3H18 LRBA SNX9 FAM135A MARCKS	2.45e-05	708	95	10	39231216
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD1A SETD1B TCOF1 PPP4R2 FNBP4 SNX9 SLX4 DNTTIP2	2.86e-05	440	95	8	34244565
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	ZC3H13 RGCC FRMPD1 KDM3B ZC3H18 RIMS1 NOL8	3.58e-05	331	95	7	19490893
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1	4.41e-05	4	95	2	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1	4.41e-05	4	95	2	9192851
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	4.41e-05	4	95	2	20639201
Pubmed	Endosomal phosphoinositides and human diseases.	PIKFYVE MTMR2	4.41e-05	4	95	2	18429927
Pubmed	Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling.	IFIH1 EIF2AK2	4.41e-05	4	95	2	18684960
Pubmed	PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.	IFIH1 EIF2AK2	4.41e-05	4	95	2	26939124
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	TPR COBLL1 ZNF335 MACF1 LRBA THOC2	4.59e-05	234	95	6	36243803
Pubmed	Interaction network of human early embryonic transcription factors.	SETD1A ZFHX4 BICRA TAF1 AHDC1 SLX4 TBL1X	5.19e-05	351	95	7	38297188
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	GPHN RIMS1 LRBA	5.51e-05	27	95	3	19723784
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	SPRED2 MTMR2 MACF1 ZC3H18 MYO18B EIF2AK2 SNX19 TASOR2	6.64e-05	496	95	8	31343991
Pubmed	Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.	SETD1A SETD1B	7.34e-05	5	95	2	25561738
Pubmed	Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis.	IFIH1 EIF2AK2	7.34e-05	5	95	2	36417848
Pubmed	The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse.	GPHN BSN	7.34e-05	5	95	2	10900017
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	GPHN TPR GTF2E1 TCOF1 PPP4R2 COBLL1 FNBP4 KDM3B	7.63e-05	506	95	8	30890647
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	PIKFYVE KIF21B TPR MARCKS RAB33B	8.77e-05	163	95	5	16512683
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	TPR RGPD2 TASOR2 BRWD1	9.34e-05	86	95	4	37253089
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	TPR USP14 GTF2E1 PPP4R2 ZBTB21 KDM3B ZC3H18 TAF1 THOC2 WDR26 EIF2AK2	1.03e-04	1014	95	11	32416067
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TPR RGPD2 TCOF1 THOC2 TASOR2 NOL8	1.03e-04	271	95	6	32433965
Pubmed	A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.	RIMS1 BSN	1.10e-04	6	95	2	19812333
Pubmed	Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.	NPAS3 MYO18B	1.10e-04	6	95	2	20713499
Pubmed	PtdIns5P regulation through evolution: roles in membrane trafficking?	PIKFYVE MTMR2	1.10e-04	6	95	2	18774718
Pubmed	Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.	RIMS1 BSN	1.10e-04	6	95	2	14734538
Pubmed	Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65.	GPHN BSN	1.10e-04	6	95	2	24554721
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	GPHN TPR TCOF1 BICRA ZC3H13 KDM3B TBL1X	1.15e-04	399	95	7	35987950
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GPHN KIF26B COBLL1 SEC24B ZBTB21 KDM3B MACF1 WDR26 GLCCI1 GARRE1	1.24e-04	861	95	10	36931259
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	RPAP1 TCOF1 BTBD7 SEC24B DVL1 KDM3B BLOC1S3 LRRC58 SOWAHC GLCCI1 TBL1X	1.26e-04	1038	95	11	26673895
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ZNF335 MTMR2 KDM3B MUC16 TAF1 GARRE1 NOL8 MUC20	1.39e-04	552	95	8	10737800
Pubmed	Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.	IFIH1 EIF2AK2	1.54e-04	7	95	2	34343497
Pubmed	CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation.	SETD1A SETD1B	1.54e-04	7	95	2	19433449
Pubmed	Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.	IFIH1 EIF2AK2	1.54e-04	7	95	2	38427731
Pubmed	Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.	GTF2E1 TAF1	1.54e-04	7	95	2	7667268
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	SETD1A TAF1 WDR26 BRWD1	1.61e-04	99	95	4	34161765
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 HEATR6 SPRED2 TCOF1 MTMR2 MACF1 TMEM131 TAF1 LRBA WDR26 SLX4 BRWD1	1.99e-04	1285	95	12	35914814
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RPAP1 TCOF1 ZC3H13 FNBP4 KIAA1549 MACF1 TMEM131 FAM135A SNX19 MARCKS DNTTIP2 NOL8 PTCD3	2.02e-04	1487	95	13	33957083
Pubmed	CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes.	SETD1A SETD1B	2.05e-04	8	95	2	18680430
Pubmed	FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO.	GTF2E1 TAF1	2.05e-04	8	95	2	9765293
Pubmed	Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication.	IFIH1 EIF2AK2	2.05e-04	8	95	2	28158275
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1A SETD1B	2.05e-04	8	95	2	23130995
Pubmed	A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).	DVL1P1 DVL1	2.05e-04	8	95	2	19643732
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	SETD1A SETD1B	2.05e-04	8	95	2	22266653
Pubmed	Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.	SETD1A SETD1B	2.05e-04	8	95	2	17355966
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	PPP4R2 AFF1 LRBA GLCCI1	2.10e-04	106	95	4	31024071
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PWWP2A SAMD1 TCOF1 ZC3H13 FNBP4 ZC3H18 THOC2 AHDC1 MXD4 DNTTIP2 TBL1X NOL8	2.12e-04	1294	95	12	30804502
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	RGPD2 EML4 COBLL1 SOWAHC EIF2AK2 MXD4 RAB33B	2.16e-04	442	95	7	15815621
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	GTF2E1 SEC24B ZBTB21 KDM3B AHDC1 SLX4 DNTTIP2	2.22e-04	444	95	7	34795231
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	GPHN TPR PTPRZ1 NFASC BSN	2.39e-04	202	95	5	33601422
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	TPR TCOF1 FNBP4 ZC3H18 THOC2	2.39e-04	202	95	5	24639526
Pubmed	A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.	GPHN BSN VSX2	2.41e-04	44	95	3	19029045
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	SPRED2 ZFHX4 NPAS3 CNTLN LRBA AGBL2	2.45e-04	318	95	6	16919269
Pubmed	Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance.	GTF2E1 TAF1	2.62e-04	9	95	2	7926747
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	SETD1A SETD1B	2.62e-04	9	95	2	22665483
Pubmed	Superresolution imaging of chemical synapses in the brain.	RIMS1 BSN	2.62e-04	9	95	2	21144999
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GPHN TPR RGPD2 DVL1 MACF1 RIMS1 BSN WDR26 NACAD MARCKS PTCD3	2.81e-04	1139	95	11	36417873
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	SETD1A SETD1B	3.28e-04	10	95	2	17998332
Interaction	CSNK2A1 interactions	SETD1A IL16 RPAP1 PHF19 TCOF1 NKAPD1 ZC3H13 DVL1 FNBP4 CDK11A MACF1 ZC3H18 SNAI1 TAF1 VSX2 SNX9 MARCKS	1.55e-06	956	93	17	int:CSNK2A1
Interaction	KDM1A interactions	TPR SAMD1 IL16 ZFHX4 PHF19 EML4 TEDC2 ZBTB21 DVL1 GCC1 SNAI1 TAF1 LRBA THOC2 WDR26 TBL1X	5.82e-06	941	93	16	int:KDM1A
Interaction	CBX3 interactions	USP14 SETD1A GTF2E1 TCOF1 ZC3H13 COBLL1 ZBTB21 CDK11A MACF1 AHDC1 SLX4 DNTTIP2 NOL8	8.24e-06	646	93	13	int:CBX3
Interaction	DDX23 interactions	ZBTB46 GTF2E1 TCOF1 NKAPD1 ZC3H13 CDK11A ZC3H18 TAF1 THOC2 DNTTIP2 NOL8	1.31e-05	480	93	11	int:DDX23
Interaction	RCOR1 interactions	TPR SAMD1 ZFHX4 EML4 ZBTB21 DVL1 SNAI1 TAF1 LRBA WDR26 TBL1X	1.71e-05	494	93	11	int:RCOR1
Interaction	PFN1 interactions	GPHN TPR USP14 COBLL1 SEC24B MACF1 ZC3H18 SOWAHC SNX9 FAM135A MARCKS	2.26e-05	509	93	11	int:PFN1
Interaction	SNRNP40 interactions	USP14 TCOF1 NKAPD1 ZC3H13 ZBTB21 DVL1 ZC3H18 AHDC1 DNTTIP2 TASOR2 TBL1X NOL8	3.61e-05	637	93	12	int:SNRNP40
Interaction	NAA40 interactions	GPHN TPR USP14 GTF2E1 TCOF1 SEC24B ZBTB21 KDM3B MACF1 LRBA THOC2 SNX9 MARCKS DNTTIP2 NOL8	3.93e-05	978	93	15	int:NAA40
Interaction	KCNA3 interactions	TPR IL16 TCOF1 COBLL1 SEC24B MACF1 ZC3H18 RIMS1 LRBA BSN THOC2 SNX9 FAM135A MARCKS	4.42e-05	871	93	14	int:KCNA3
GeneFamily	CD molecules\|Mucins	MUC17 MUC16 MUC22 MUC20	8.70e-07	21	65	4	648
GeneFamily	PDZ domain containing	IL16 FRMPD1 DVL1 RIMS1 PDZD2	2.16e-04	152	65	5	1220
GeneFamily	WD repeat domain containing	KIF21B EML4 LRBA WDR26 TBL1X BRWD1	3.53e-04	262	65	6	362
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB46 BTBD7 ZBTB21 SLX4	1.38e-03	134	65	4	861
Coexpression	GSE22886_TH1_VS_TH2_12H_ACT_UP	KIF21B SPRED2 RPAP1 BTBD7 NKAPD1 TMEM131 RAB33B	7.66e-06	199	94	7	M4507
Coexpression	GSE12392_IFNAR_KO_VS_IFNB_KO_CD8_NEG_SPLEEN_DC_UP	ZBTB46 PPP4R2 RGCC SEC24B ZBTB21 CNTLN BRWD1	7.66e-06	199	94	7	M7142
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_6H_DN	BTBD7 FNBP4 KDM3B AFF1 TMEM131 SNX19	2.21e-05	157	94	6	M7733
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	PIKFYVE SPRED2 SEC24B KDM3B AFF1 MACF1 TMEM131 THOC2 AHDC1 GARRE1 TBL1X PHLPP2	5.58e-05	856	94	12	M4500
Coexpression	GSE13411_NAIVE_BCELL_VS_PLASMA_CELL_UP	PIKFYVE KIF21B EML4 VPS8 MACF1 GCC1	7.64e-05	196	94	6	M3243
Coexpression	GSE29617_CTRL_VS_DAY3_TIV_FLU_VACCINE_PBMC_2008_UP	ZBTB46 SETD1B EML4 ZBTB21 TASOR2 PTCD3	7.64e-05	196	94	6	M4928
Coexpression	GSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_UP	PIKFYVE PWWP2A COBLL1 DVL1 MXD4 RAB33B	8.54e-05	200	94	6	M9447
Coexpression	GSE45881_CXCR6HI_VS_CXCR1LO_COLONIC_LAMINA_PROPRIA_UP	KIF21B SETD1B EML4 VPS8 MACF1 THOC2	8.54e-05	200	94	6	M9889
Coexpression	GSE40068_CXCR5POS_BCL6POS_TFH_VS_CXCR5NEG_BCL6NEG_CD4_TCELL_DN	SPRED2 CSRNP2 MTMR2 AFF1 THOC2 MARCKS	8.54e-05	200	94	6	M9262
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2	TPR GTF2E1 CSRNP2 NKAPD1 PPP4R2 ZC3H13 SEC24B MACF1 TMEM131 THOC2 FAM135A TBL1X BRWD1	1.06e-06	564	93	13	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlas	DevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#1_top-relative-expression-ranked_500	ZBTB46 KIAA1549 CNTLN FAM135A BRWD1	4.49e-05	89	93	5	gudmap_developingKidney_e15.5_Peripheral blastema_500_k1
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	ZFHX4 NPAS3 KIAA1549 TMEM131 CNTLN LRRC58 GLCCI1	2.37e-07	199	95	7	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B SPRED2 BICRA MYO18B LRRC58 AHDC1	2.07e-06	175	95	6	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	PIKFYVE TCOF1 COBLL1 TMEM131 SNX9 MARCKS	3.33e-06	190	95	6	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|Dendritic_cell / Region, Cell class and subclass	PIKFYVE SETD1B SPRED2 CNTLN MARCKS TBL1X	4.48e-06	200	95	6	3813fa1ee1462ba83fd8b6253070f46f0b063084
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	BICDL1 EML4 MACF1 LRBA PHLPP2	1.05e-05	135	95	5	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	BICDL1 EML4 FNBP4 MACF1 LRBA	2.54e-05	162	95	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Endothelial-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	ZFHX4 KIF26B NFASC NACAD MARCKS	3.38e-05	172	95	5	d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFIH1 RGCC TMEM131 BSN MARCKS	3.47e-05	173	95	5	5d7c53c6d1cdd385e44b79b82faec901747d1736
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 RGCC TMEM131 BSN MARCKS	3.57e-05	174	95	5	0fccd90ef72ec2e5eb369fe6d6d126c60886485a
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 RGCC TMEM131 BSN MARCKS	3.57e-05	174	95	5	b2fc2a756f8e373ad903bd416d9de703d945fa1c
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFIH1 RGCC TMEM131 BSN MARCKS	3.57e-05	174	95	5	9eab43885496b8586f8ec5b4bcb1fd5b209218e5
ToppCell	ASK428-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	PIKFYVE COBLL1 MUC16 RIMS1 PDZD2	3.67e-05	175	95	5	e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	HEATR6 STARD8 NKAPD1 COBLL1 SLX4	3.77e-05	176	95	5	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B SETD1A TEDC2 KIAA1549 GCC1	4.09e-05	179	95	5	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 PPP4R2 RGCC GCC1 FAM135A	4.91e-05	186	95	5	39e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STARD8 PPP4R2 RGCC GCC1 FAM135A	4.91e-05	186	95	5	02418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TPR EML4 ZC3H13 TMEM131 TAF1	4.91e-05	186	95	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SETD1A BICDL1 VPS8 SNX9 TBL1X	5.03e-05	187	95	5	c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCell	facs-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 LRRC58 GLCCI1 MARCKS BRWD1	5.03e-05	187	95	5	3ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	EML4 MACF1 TMEM131 LRBA TASOR2	5.16e-05	188	95	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCOF1 COBLL1 AFF1 SNX9 MARCKS	5.29e-05	189	95	5	b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCOF1 COBLL1 GLCCI1 MARCKS BRWD1	5.70e-05	192	95	5	2de242d81dc085ae734eb7d1f091af9a542e0866
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCOF1 COBLL1 GLCCI1 MARCKS BRWD1	5.70e-05	192	95	5	ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	AFF1 LRRC58 THOC2 EIF2AK2 TASOR2	5.84e-05	193	95	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE TCOF1 COBLL1 SNX9 MARCKS	5.99e-05	194	95	5	5cd72330c9d9bb21b6c9d5d35085eade101486d1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE TCOF1 EML4 COBLL1 SNX9	5.99e-05	194	95	5	87604c93d20f9171e0a1279bdb6ad73fe5fed356
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE TCOF1 COBLL1 SNX9 MARCKS	6.14e-05	195	95	5	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE TCOF1 COBLL1 SNX9 MARCKS	6.14e-05	195	95	5	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PWWP2A MACF1 LRBA MYO18B MARCKS	6.14e-05	195	95	5	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GPHN COBLL1 LRBA GLCCI1 PDZD2	6.14e-05	195	95	5	9406866f99555198a9be311fbd65751b70f35446
ToppCell	T_cells-Treg_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	GPHN BICDL1 IL16 RGCC GLCCI1	6.44e-05	197	95	5	de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIF26B PTPRZ1 MUC16 RIMS1 MUC20	6.60e-05	198	95	5	28ada093cec552262731194a04a4b9ff93186c3b
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4\|GI_small-bowel / Manually curated celltypes from each tissue	BICDL1 EML4 RGCC SNX9 PDZD2	6.60e-05	198	95	5	6333e46cd1ccf5841ce15aea98a4b2f5e3ae4675
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17\|GI_small-bowel / Manually curated celltypes from each tissue	BICDL1 EML4 RGCC SNX9 PDZD2	6.75e-05	199	95	5	508a6efc11b1b45899a968888865731088cac668
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	ZC3H13 COBLL1 RGCC LRRC58 GLCCI1	6.75e-05	199	95	5	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	TPR ZC3H13 THOC2 EIF2AK2 DNTTIP2	6.75e-05	199	95	5	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GPHN KCNG2 PTPRZ1 COBLL1 NPAS3	6.92e-05	200	95	5	9f21e4e0913d8ef95a3f771dff0abaad8fe1d9f2
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	KIF21B SETD1A ZFHX4 NPAS3 NFASC	6.92e-05	200	95	5	c92e4fc0442404481fcac623d691dae6215b852d
Disease	neurodevelopmental disorder with speech impairment and dysmorphic facies (implicated_via_orthology)	SETD1A SETD1B	1.00e-05	2	94	2	DOID:0070417 (implicated_via_orthology)
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	9.98e-05	5	94	2	DOID:11198 (is_implicated_in)
Disease	unipolar depression, bipolar disorder, mental or behavioural disorder	NPAS3 MYO18B	1.49e-04	6	94	2	EFO_0000677, EFO_0003761, MONDO_0004985
Disease	sex interaction measurement, Crohn's disease	SPRED2 BSN MUC22	2.25e-04	37	94	3	EFO_0000384, EFO_0008343
Disease	helix rolling	LRBA SOWAHC	2.78e-04	8	94	2	EFO_0007670
Disease	peripheral arterial disease, traffic air pollution measurement	IL16 PPP4R2 MACF1 RIMS1 LRBA	3.99e-04	194	94	5	EFO_0004265, EFO_0007908
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	AKAP6 NPAS3 KDM3B RIMS1 SNX19	4.58e-04	200	94	5	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	Intellectual Disability	AKAP6 SETD1A ZNF335 KDM3B MACF1 TAF1 WDR26	5.76e-04	447	94	7	C3714756
Disease	platelet component distribution width	PWWP2A STARD8 BTBD7 COBLL1 MACF1 BLOC1S3 AGBL2 SNX9 BRWD1	6.87e-04	755	94	9	EFO_0007984
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	COBLL1 ZNF335 AFF1 MACF1 LRBA	7.80e-04	225	94	5	EFO_0008317, EFO_0020947
Disease	urate measurement, bone density	AKAP6 USP14 HEATR6 NPAS3 BLOC1S3 FAM135A SNX19 PDZD2	8.20e-04	619	94	8	EFO_0003923, EFO_0004531
Disease	nervousness	FNBP4 AGBL2	1.17e-03	16	94	2	NCIT_C74532
Disease	Alzheimer disease, educational attainment	SPRED2 MTMR2 BSN SNX19 GLCCI1	1.18e-03	247	94	5	EFO_0011015, MONDO_0004975
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	COBLL1 AFF1 MACF1 LRBA	1.37e-03	150	94	4	EFO_0004611, EFO_0020947
Disease	gait measurement	AKAP6 GPHN NPAS3 AGBL2	1.37e-03	150	94	4	EFO_0007680
Disease	Brugada syndrome	SCN5A MYO18B	1.66e-03	19	94	2	MONDO_0015263
Disease	free cholesterol to total lipids in large LDL percentage	COBLL1 AFF1 MACF1	1.72e-03	74	94	3	EFO_0022280
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	AKAP6 NPAS3 GCC1 BSN GLCCI1 BRWD1	1.74e-03	398	94	6	EFO_0003756, EFO_0003888, EFO_0004337
Disease	psoriasis, type 2 diabetes mellitus	IFIH1 COBLL1 SNAI1	1.79e-03	75	94	3	EFO_0000676, MONDO_0005148
Disease	diet measurement	ZBTB46 RPAP1 MUC17 KIF26B MTMR2 NPAS3 KDM3B RIMS1 GLCCI1 RAB33B	1.88e-03	1049	94	10	EFO_0008111
Disease	HIV-1 infection, Susceptibility to viral and mycobacterial infections	BICRA FRMPD1	2.03e-03	21	94	2	EFO_0000180, Orphanet_391311
Disease	bipolar disorder	AKAP6 BICRA NPAS3 KDM3B TMEM131 RIMS1 SNX19	2.49e-03	577	94	7	MONDO_0004985
Disease	inflammatory bowel disease (implicated_via_orthology)	IL16 PDZD2	2.87e-03	25	94	2	DOID:0050589 (implicated_via_orthology)
Disease	multiple sclerosis	SETD1A ZBTB46 SPRED2 RGCC AFF1 AGBL2 MARCKS	2.93e-03	594	94	7	MONDO_0005301
Disease	Antiglaucoma preparations and miotics use measurement	FNBP4 AGBL2	3.10e-03	26	94	2	EFO_0009944
Disease	ankylosing spondylitis	AKAP6 KIF21B NPAS3	3.11e-03	91	94	3	EFO_0003898

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDVSESSSDSEAQTS	CNTLN	866	Q9NXG0
SVSNSDDEISSSDSA	CSRNP2	21	Q9H175
VSFTSLSDDTSTAGS	GLCCI1	501	Q86VQ1
QTAVSETFSESSSDS	AHDC1	1156	Q5TGY3
AVSTDSSMDESSETS	BICDL1	391	Q6ZP65
TDVSSAADSVESTAF	COBLL1	31	Q53SF7
ESSLEASFSSSGAVS	RAB33B	6	Q9H082
DSGVASTEDSSSSHI	GPHN	221	Q9NQX3
VSPSDADSTVSEESS	KIAA1549	1411	Q9HCM3
SSDASAVKTETSTSE	MUC16	3646	Q8WXI7
ETSTSEETSLATEAN	MUC16	7546	Q8WXI7
LTALTSDSDTDSSSD	PTCD3	666	Q96EY7
VRTDSTGSAVSTDDS	MXD4	141	Q14582
ASAETLSTAGTTESA	MUC20	476	Q8N307
TADSETTAASTTGSE	MUC22	411	E2RYF6
TAASTEDSETNTAFT	MUC22	506	E2RYF6
ADSENTTASTADSET	MUC22	851	E2RYF6
SSSSSDSDTDVKSHA	IMUP	56	Q9GZP8
EATGSASSAQDSTSE	KIF26B	1906	Q2KJY2
DATASSSSAAATVRA	BSN	2646	Q9UPA5
SDEETSSDVKSSCSS	FAM135A	926	Q9P2D6
EDSTHSATATEDSSQ	KCNG2	431	Q9UJ96
SCAEETTEVTSASSA	PDZD2	1691	O15018
SGAEVSASTTSSEAE	KIF21B	846	O75037
DSAASASAASDVSVE	IL16	1211	Q14005
ASAASDVSVESTAEA	IL16	1216	Q14005
AAEKDGVSSSFSSSS	HEATR6	376	Q6AI08
TTVSESLADDSSSRD	KDM3B	541	Q7LBC6
ETQSACSDTSESSAA	MACF1	3466	O94854
LTTASVEESESTSSA	LRBA	1586	P50851
SASVVSSDSISTSAD	MTMR2	41	Q13614
SHSSSSEDADSASEL	NOL8	451	Q76FK4
SARNASEDSTSSGSE	PTPRZ1	626	P23471
STSQSESDSEDEASV	LRRC58	346	Q96CX6
DSDVSDVSAISRTSS	RIMS1	1341	Q86UR5
SSTDATAIAATTEAT	NFASC	1051	O94856
SSFQSTVDSDSAASI	PIKFYVE	501	Q9Y2I7
SEDSTGTATSLDTAA	GCC1	91	Q96CN9
STLASESSSEGDFSA	EIF2AK2	196	P19525
TTDSAESEASDSANT	FRMPD1	581	Q5SYB0
AQGDSASSSDETSSA	GARRE1	906	O15063
ASSSDETSSANGDSL	GARRE1	911	O15063
ESSFADSSVVSESDT	IFIH1	246	Q9BYX4
SDISLSDIESSTSGS	AGBL2	706	Q5U5Z8
SDSERKTSSAESSSA	CDK11A	271	Q9UQ88
EVEDSLATSLSSSAS	BRWD1	1531	Q9NSI6
EATETDSERSASSSE	BLOC1S3	21	Q6QNY0
AAATTTSTATAAAAA	BTBD7	841	Q9P203
AAEGEAASAASSTSS	MARCKS	121	P29966
DSASTALSSELESSS	DVL1	176	O14640
GSLDDSISAASTSDV	EML4	6	Q9HC35
DSASTALSSELESSS	DVL1P1	176	P54792
SSSSSSAASSLDADE	BICRA	1271	Q9NZM4
ETAAAATTAAAASSS	SAMD1	11	Q6SPF0
EEAGVDSSSTTSSAS	SEC24B	386	O95487
NHSDSSTSESEVSSV	PPP4R2	211	Q9NY27
SSSSSNSVKEDTAAA	OR1P1	276	Q8NH06
TASEASSSPTTAEDT	MUC17	426	Q685J3
TNSTEASSSATAEGS	MUC17	2076	Q685J3
VTAANGSDSESETSE	GTF2E1	346	P29083
DSLSASTAQASSSAA	SNX9	81	Q9Y5X1
DSSSASVCSIDSTDD	PWWP2A	576	Q96N64
VSAGQADSSSEDTSS	TCOF1	191	Q13428
SSTQTSDSTDAAAAK	TEDC2	226	Q7L2K0
TTTTAVTAAAASDDS	FNBP4	56	Q8N3X1
ADAASEVEVSSTSET	RGPD2	1506	P0DJD1
EVLSTDTDSSSAEDS	TAF1	1081	P21675
SQVSATASSEAEASA	SCN5A	1096	Q14524
DEKESLSASSSSSAS	SETD1B	1036	Q9UPS6
VTSKAEATSSSESSE	SETD1B	1146	Q9UPS6
AEDGASSASSSSQSE	NPAS3	226	Q8IXF0
DTSSVASSDSGDRTN	VPS8	101	Q8N3P4
DSDSASVASSSAEEE	SOWAHC	241	Q53LP3
AIAATTAATASSSAS	SETD1A	326	O15047
ISDTVASSSELDSSG	STARD8	441	Q92502
ESVATSVDGSDSSLS	SLX4	1701	Q8IY92
SSLSADDADTVALSS	AKAP6	2201	Q13023
VASAHSSSAESESTS	AFF1	461	P51825
NTSHSDDSASSSSEE	NKAPD1	226	Q6ZUT1
AAATAAATAATTTSA	TBL1X	166	O60907
AETSSSDISFSGIAT	DNTTIP2	186	Q5QJE6
SSFSSTSVSSLEAEA	SNAI1	111	O95863
GTSSSSATVSDDTEK	ZFHX4	521	Q86UP3
DETSSINTAISDATT	ZFHX4	2756	Q86UP3
VTVGDAATTAAASSS	ZBTB21	446	Q9ULJ3
AATTAAASSSSVTRD	ZBTB21	451	Q9ULJ3
SSIGSASKSDESSTE	THOC2	1211	Q8NI27
TSEVSSEVGSTASDE	PHLPP2	1086	Q6ZVD8
TESTTSDASEHASQS	TPR	2226	P12270
ASVSDSSGFSDSESA	RGCC	66	Q9H4X1
SLADDDSSSTTTETS	TMEM131	1416	Q92545
VDSTDAASTSGSAST	PHF19	446	Q5T6S3
DDDVFTTATDSSSNS	SPRED2	141	Q7Z698
AETISDSAEASLSAT	RPAP1	741	Q9BWH6
SASVEESAATTSASD	SNX19	966	Q92543
EVASSDSDTESVQTA	MYO18B	2086	Q8IUG5
SSDASQSSSVSVEHS	TASOR2	641	Q5VWN6
AASSATVAAASATTA	WDR26	86	Q9H7D7
DSVKETDSSSASAAT	USP14	221	P54578
TSEAVSADSSDAAAA	ZNF335	31	Q9H4Z2
DSNADLSVTEASSSD	ZBTB46	311	Q86UZ6
ATTAAAATSFSTSAI	ZC3H13	1121	Q5T200
ATSSSSSAHSVDSED	ZC3H18	716	Q86VM9
DTSQTASSDSEDVSS	VSX2	116	P58304
RDDTSAASSDSDSAS	NACAD	381	O15069