Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-7 ERVK-21 ERVK-24	2.47e-04	37	66	3	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-7 ERVK-21 ERVK-24	2.68e-04	38	66	3	GO:0070001
GeneOntologyBiologicalProcess	axial mesoderm formation	EPHA2 NODAL	2.75e-05	3	63	2	GO:0048320
GeneOntologyBiologicalProcess	protein localization to plasma membrane	GRIP1 EPHA2 SPTBN1 GAS6 CRB3 DLG1 ZDHHC4	5.76e-05	324	63	7	GO:0072659
GeneOntologyBiologicalProcess	positive regulation of protein localization to plasma membrane	GRIP1 EPHA2 SPTBN1 DLG1	6.23e-05	70	63	4	GO:1903078
GeneOntologyBiologicalProcess	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TNRC6B TNRC6C DHX9	7.54e-05	27	63	3	GO:1900151
GeneOntologyBiologicalProcess	axial mesoderm morphogenesis	EPHA2 NODAL	9.13e-05	5	63	2	GO:0048319
GeneOntologyBiologicalProcess	regulation of cell adhesion	CD1D LMO7 EPHA2 PIEZO1 PKHD1 TMEM131L DLG1 CLEC4M EDIL3 NODAL VAV1	1.03e-04	927	63	11	GO:0030155
GeneOntologyBiologicalProcess	positive regulation of protein localization to cell periphery	GRIP1 EPHA2 SPTBN1 DLG1	1.16e-04	82	63	4	GO:1904377
GeneOntologyBiologicalProcess	receptor-mediated virion attachment to host cell	GAS6 CLEC4M	1.37e-04	6	63	2	GO:0046813
GeneOntologyBiologicalProcess	cerebral cortex tangential migration	RELN FBXO45	1.91e-04	7	63	2	GO:0021800
MousePheno	glomerular crescent	CD1D GAS6 CD151	4.78e-05	19	53	3	MP:0011506
MousePheno	renal interstitial fibrosis	CD1D PKHD1 CRB3 CD151	5.06e-05	54	53	4	MP:0003215
Domain	Aha1_N	AHSA2P AHSA1	9.48e-06	2	58	2	PF09229
Domain	AHSA1_N	AHSA2P AHSA1	9.48e-06	2	58	2	IPR015310
Domain	Aha1_N	AHSA2P AHSA1	9.48e-06	2	58	2	SM01000
Domain	Ago_hook	TNRC6B TNRC6C	2.84e-05	3	58	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6B TNRC6C	2.84e-05	3	58	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6B TNRC6C	2.84e-05	3	58	2	IPR019486
Domain	RFX1_trans_act	RFX2 RFX3	2.84e-05	3	58	2	IPR007668
Domain	TNRC6-PABC_bdg	TNRC6B TNRC6C	2.84e-05	3	58	2	PF16608
Domain	RFX1_trans_act	RFX2 RFX3	2.84e-05	3	58	2	PF04589
Domain	CH	SPTBN5 LMO7 SPTBN1 VAV1	4.92e-05	65	58	4	SM00033
Domain	CH	SPTBN5 LMO7 SPTBN1 VAV1	6.59e-05	70	58	4	PF00307
Domain	-	SPTBN5 LMO7 SPTBN1 VAV1	6.97e-05	71	58	4	1.10.418.10
Domain	CH	SPTBN5 LMO7 SPTBN1 VAV1	7.77e-05	73	58	4	PS50021
Domain	CH-domain	SPTBN5 LMO7 SPTBN1 VAV1	8.63e-05	75	58	4	IPR001715
Domain	PH_dom-spectrin-type	SPTBN5 SPTBN1	3.36e-04	9	58	2	IPR001605
Domain	RFX_DNA_binding	RFX2 RFX3	3.36e-04	9	58	2	PF02257
Domain	DNA-bd_RFX	RFX2 RFX3	3.36e-04	9	58	2	IPR003150
Domain	RFX_DBD	RFX2 RFX3	3.36e-04	9	58	2	PS51526
Domain	SM22_calponin	LMO7 VAV1	5.12e-04	11	58	2	IPR003096
Domain	UBA-like	TNRC6B TNRC6C HUWE1	1.04e-03	64	58	3	IPR009060
Domain	-	EPHA2 CPXM1 EDIL3	1.52e-03	73	58	3	2.60.120.260
Domain	FA58C	CPXM1 EDIL3	1.92e-03	21	58	2	SM00231
Domain	FA58C_3	CPXM1 EDIL3	1.92e-03	21	58	2	PS50022
Domain	FA58C_1	CPXM1 EDIL3	1.92e-03	21	58	2	PS01285
Domain	FA58C_2	CPXM1 EDIL3	1.92e-03	21	58	2	PS01286
Domain	Actinin_actin-bd_CS	SPTBN5 SPTBN1	2.30e-03	23	58	2	IPR001589
Domain	Spectrin	SPTBN5 SPTBN1	2.30e-03	23	58	2	PF00435
Domain	ACTININ_2	SPTBN5 SPTBN1	2.30e-03	23	58	2	PS00020
Domain	ACTININ_1	SPTBN5 SPTBN1	2.30e-03	23	58	2	PS00019
Domain	F5_F8_type_C	CPXM1 EDIL3	2.50e-03	24	58	2	PF00754
Domain	FA58C	CPXM1 EDIL3	2.50e-03	24	58	2	IPR000421
Domain	Galactose-bd-like	EPHA2 CPXM1 EDIL3	3.12e-03	94	58	3	IPR008979
Domain	HECT	HUWE1 HERC1	3.16e-03	27	58	2	PF00632
Domain	HECTc	HUWE1 HERC1	3.16e-03	27	58	2	SM00119
Domain	HECT_dom	HUWE1 HERC1	3.16e-03	27	58	2	IPR000569
Domain	HECT	HUWE1 HERC1	3.16e-03	27	58	2	PS50237
Domain	hEGF	GAS6 EDIL3	3.40e-03	28	58	2	PF12661
Domain	Spectrin_repeat	SPTBN5 SPTBN1	3.65e-03	29	58	2	IPR002017
Domain	UBA	TNRC6C HUWE1	3.90e-03	30	58	2	SM00165
Domain	Spectrin/alpha-actinin	SPTBN5 SPTBN1	4.43e-03	32	58	2	IPR018159
Domain	SPEC	SPTBN5 SPTBN1	4.43e-03	32	58	2	SM00150
Domain	ConA-like_dom	GAS6 ADGRD2 HERC1 FBXO45	4.76e-03	219	58	4	IPR013320
Domain	UBA	TNRC6C HUWE1	5.58e-03	36	58	2	PF00627
Domain	G_PROTEIN_RECEP_F2_1	ADGRD2 GLP2R	6.85e-03	40	58	2	PS00649
Domain	GPCR_2_extracellular_dom	ADGRD2 GLP2R	6.85e-03	40	58	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	ADGRD2 GLP2R	6.85e-03	40	58	2	PS50227
Domain	UBA	TNRC6C HUWE1	8.25e-03	44	58	2	IPR015940
Domain	EGF-like_CS	RELN EPHA2 GAS6 EDIL3	8.76e-03	261	58	4	IPR013032
Domain	EGF_2	RELN EPHA2 GAS6 EDIL3	9.23e-03	265	58	4	PS01186
Pathway	REACTOME_CELL_CELL_COMMUNICATION	SPTBN1 CRB3 TNRC6B CD151 TNRC6C	1.29e-04	155	45	5	M522
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6B TNRC6C	2.07e-04	7	45	2	M46421
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	TNRC6B TNRC6C	3.54e-04	9	45	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	TNRC6B TNRC6C	3.54e-04	9	45	2	M46436
Pathway	REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION	SPTBN5 COPA CTAGE1 SPTBN1 B4GALT5	4.41e-04	202	45	5	MM15650
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	TNRC6B TNRC6C	4.41e-04	10	45	2	M48013
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN5 SPTBN1	4.41e-04	10	45	2	MM15112
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	CRB3 TNRC6B CD151 TNRC6C	5.16e-04	117	45	4	M19248
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	TNRC6B TNRC6C	7.60e-04	13	45	2	M46434
Pubmed	RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.	RFX2 NODAL RFX3	2.38e-07	7	67	3	22233545
Pubmed	A Defect in Thymic Tolerance Causes T Cell-Mediated Autoimmunity in a Murine Model of COPA Syndrome.	COPA EDIL3	3.66e-06	2	67	2	32198142
Pubmed	Lmo7 is dispensable for skeletal muscle and cardiac function.	LMO7 EDIL3	3.66e-06	2	67	2	26157009
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	COPA LMO7 EPHA2 SPTBN1 HUWE1 AHSA1	6.31e-06	235	67	6	28378594
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX2 RFX3	1.10e-05	3	67	2	15024578
Pubmed	Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.	AHSA2P AHSA1	1.10e-05	3	67	2	12604615
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX2 RFX3	1.10e-05	3	67	2	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX2 RFX3	1.10e-05	3	67	2	22415835
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6B TNRC6C	1.10e-05	3	67	2	34108231
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX2 RFX3	1.10e-05	3	67	2	12403718
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX2 RFX3	1.10e-05	3	67	2	8289803
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6B TNRC6C	1.10e-05	3	67	2	16880270
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX2 RFX3	1.10e-05	3	67	2	32725242
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6B TNRC6C	1.10e-05	3	67	2	31670606
Pubmed	Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice.	PIEZO1 EDIL3	1.10e-05	3	67	2	37917195
Pubmed	HELZ2 promotes K63-linked polyubiquitination of c-Myc to induce retinoblastoma tumorigenesis.	HELZ2 HUWE1	1.10e-05	3	67	2	34761308
Pubmed	Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.	AHSA2P AHSA1	1.10e-05	3	67	2	12504007
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	TNRC6C HUWE1 AHSA1 USP47	1.45e-05	76	67	4	27542412
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	COPA LMO7 SPTBN1 HELZ2 DLG1 SCAF11 HUWE1 USP47 DHX9	1.73e-05	774	67	9	15302935
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	SPTBN1 TNRC6B TNRC6C DHX9	1.78e-05	80	67	4	35803934
Pubmed	Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes.	DLG1 VAV1	2.19e-05	4	67	2	19139088
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX2 RFX3	2.19e-05	4	67	2	11682486
Pubmed	Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.	HUWE1 EDIL3	2.19e-05	4	67	2	38453366
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX2 RFX3	2.19e-05	4	67	2	19596083
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-24	2.19e-05	4	67	2	10469592
Pubmed	The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation.	CRB3 DLG1	2.19e-05	4	67	2	17332497
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6B TNRC6C	2.19e-05	4	67	2	21063388
Pubmed	MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.	TNRC6B UPF1	2.19e-05	4	67	2	24726324
Pubmed	Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.	PIEZO1 EDIL3	2.19e-05	4	67	2	30979871
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	COPA LMO7 EPHA2 SPTBN1 TNRC6B DLG1 UPF1 HUWE1 MED13L AHSA1 DHX9	2.45e-05	1247	67	11	27684187
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-7 ERVK-21	3.64e-05	5	67	2	12629516
Pubmed	Beta-glycoglycosphingolipid-induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2.	CD1D STAT4	3.64e-05	5	67	2	19246642
Pubmed	CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis.	CD1D STAT4	3.64e-05	5	67	2	19338001
Pubmed	Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.	TNRC6B TNRC6C	3.64e-05	5	67	2	19838187
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	COPA LMO7 SPTBN1 SCAF11 UPF1 HUWE1	4.42e-05	332	67	6	32786267
Pubmed	Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers.	DLG1 EDIL3	5.46e-05	6	67	2	31066677
Pubmed	Identification and characterization of a seven transmembrane hormone receptor using differential display.	RFX2 VAV1	5.46e-05	6	67	2	9169125
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	GRIP1 COPA EPHA2 SPTBN1 TNRC6B DLG1 UPF1 DHX9	6.42e-05	708	67	8	39231216
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	LMO7 HELZ2 TNRC6B TNRC6C MED13L	7.55e-05	225	67	5	12168954
Pubmed	The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification.	NODAL RFX3	7.63e-05	7	67	2	15121860
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6B TNRC6C	7.63e-05	7	67	2	19470757
Pubmed	Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels.	TC2N CLEC4M	7.63e-05	7	67	2	21029358
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6B TNRC6C	7.63e-05	7	67	2	19383768
Pubmed	Human transcription factor protein interaction networks.	COPA DNAH10 SPTBN1 TNRC6B SCAF11 UPF1 USP54 TNRC6C HERC1 ZKSCAN4 STAT4	8.40e-05	1429	67	11	35140242
Pubmed	Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse.	EDIL3 NODAL	1.02e-04	8	67	2	20689803
Pubmed	Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor.	EPHA2 VAV1	1.02e-04	8	67	2	8405064
Pubmed	Molecular architecture of lineage allocation and tissue organization in early mouse embryo.	CRB3 NODAL	1.02e-04	8	67	2	31391582
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	COPA LMO7 EPHA2 SPTBN1 UPF1 AHSA1 DHX9	1.27e-04	580	67	7	35676659
Pubmed	Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.	CRB3 DLG1	1.30e-04	9	67	2	22410172
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	RFX2 VAV1	1.30e-04	9	67	2	8661125
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	COPA LMO7 SPTBN1 HELZ2 DLG1 SCAF11 UPF1 EDIL3 AHSA1 DHX9	1.40e-04	1257	67	10	36526897
Pubmed	Role of the gut endoderm in relaying left-right patterning in mice.	EDIL3 NODAL	1.63e-04	10	67	2	22412348
Pubmed	Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.	EDIL3 NODAL	1.63e-04	10	67	2	27924807
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RELN COPA LMO7 SPTBN1 DLG1 USP54 HUWE1 MED13L EDIL3 USP47	1.67e-04	1285	67	10	35914814
Pubmed	Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.	TNRC6B UPF1 DHX9	1.86e-04	57	67	3	17932509
Pubmed	G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.	RFX2 RFX3	1.99e-04	11	67	2	18218630
Pubmed	Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens.	EPHA2 DLG1	1.99e-04	11	67	2	26906157
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	DNAH10 SPTBN1 PKHD1 HERC1 DHX9	1.99e-04	277	67	5	30745168
Pubmed	The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53.	SPTBN1 UPF1 DHX9	2.06e-04	59	67	3	32382008
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RELN COPA SPTBN1 HELZ2 TNRC6B UPF1 EDIL3 FBXO45 DHX9	2.24e-04	1082	67	9	38697112
Pubmed	The Zic2 gene directs the formation and function of node cilia to control cardiac situs.	NODAL RFX3	2.38e-04	12	67	2	24585447
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	LMO7 UPF1 HUWE1 HERC1	2.46e-04	157	67	4	30686591
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	COPA LMO7 SPTBN1 TNRC6B UPF1 HUWE1 AHSA1	2.47e-04	647	67	7	26618866
Pubmed	Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.	COPA LMO7 SPTBN1 DHX9	2.58e-04	159	67	4	34537242
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	COPA SPTBN1 HELZ2 SCAF11 UPF1 HUWE1 USP47	2.61e-04	653	67	7	22586326
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	HUWE1 DHX9	2.81e-04	13	67	2	29285303
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	NODAL RFX3	2.81e-04	13	67	2	17884984
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN5 SPTBN1	2.81e-04	13	67	2	18796539
Pubmed	14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.	COPA LMO7 DHX9	2.87e-04	66	67	3	23472066
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	COPA HELZ2 UPF1 HUWE1 AHSA1 DHX9	2.90e-04	469	67	6	37314180
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	TNRC6B TNRC6C	3.28e-04	14	67	2	19716330
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	COPA SPTBN1 UPF1 EDIL3 DHX9	3.45e-04	312	67	5	37120454
Pubmed	Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.	COPA EPHA2	3.78e-04	15	67	2	36963288
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MED13L FBXO45	3.78e-04	15	67	2	31285543
Pubmed	Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning.	EDIL3 NODAL	3.78e-04	15	67	2	15302604
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6B TNRC6C	3.78e-04	15	67	2	21981923
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	COPA SPTBN1 TNRC6B UPF1 TNRC6C DHX9	3.82e-04	494	67	6	26831064
Pubmed	Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.	EDIL3 NODAL	4.31e-04	16	67	2	15215210
Pubmed	Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast.	EDIL3 NODAL	4.31e-04	16	67	2	25480920
Pubmed	Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.	RFX2 RFX3	4.88e-04	17	67	2	31068677
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	NODAL RFX3	4.88e-04	17	67	2	22357932
Pubmed	Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.	EDIL3 NODAL	4.88e-04	17	67	2	20040491
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	COPA SPTBN1 HELZ2 UPF1 HUWE1	5.37e-04	344	67	5	30333137
Pubmed	Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification.	EDIL3 NODAL	5.48e-04	18	67	2	27521049
Pubmed	Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.	GRIP1 DLG1	5.48e-04	18	67	2	18311135
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-24	5.48e-04	18	67	2	18664271
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN5 SPTBN1	5.48e-04	18	67	2	12119179
Pubmed	Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.	TC2N CLEC4M	5.48e-04	18	67	2	21810271
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TNRC6B DLG1 SCAF11 MED13L NODAL B4GALT5	5.87e-04	536	67	6	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TNRC6B DLG1 SCAF11 MED13L NODAL B4GALT5	5.98e-04	538	67	6	10512203
Pubmed	Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.	EDIL3 STAT4	6.12e-04	19	67	2	32075740
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	PKHD1 SCAF11 USP54 DHX9	6.36e-04	202	67	4	24639526
Pubmed	Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.	DLG1 EDIL3	6.79e-04	20	67	2	23661808
Pubmed	Cell fate decisions within the mouse organizer are governed by graded Nodal signals.	EDIL3 NODAL	6.79e-04	20	67	2	12842913
Pubmed	Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion.	DLG1 FBXO45	6.79e-04	20	67	2	30976085
Pubmed	Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.	RELN CRB3	6.79e-04	20	67	2	26802325
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	TNRC6B UPF1	7.50e-04	21	67	2	33029523
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	RELN HUWE1	7.50e-04	21	67	2	19686682
Pubmed	Rfx6 directs islet formation and insulin production in mice and humans.	RFX2 RFX3	7.50e-04	21	67	2	20148032
Pubmed	Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.	EDIL3 NODAL	7.50e-04	21	67	2	20562861
Cytoband	12q14.1	ERVK-21 CAPS2	7.74e-04	28	67	2	12q14.1
Cytoband	11p15	ART1 IRAG1	1.82e-03	43	67	2	11p15
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN5 SPTBN1	1.38e-04	7	47	2	1113
GeneFamily	Regulatory factor X family	RFX2 RFX3	1.83e-04	8	47	2	1153
GeneFamily	UPF1 like RNA helicases	HELZ2 UPF1	3.58e-04	11	47	2	1169
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6B TNRC6C	1.91e-03	25	47	2	775
Coexpression	GSE40273_XBP1_KO_VS_WT_TREG_DN	LIPC LMO7 HELZ2 TNRC6B HERC1 B4GALT5	9.23e-06	199	64	6	M9124
Coexpression	WANG_LSD1_TARGETS_UP	CD1D RELN GAS6	2.71e-05	24	64	3	MM739
Coexpression	WANG_LSD1_TARGETS_UP	CD1D RELN GAS6	2.71e-05	24	64	3	M1759
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TC2N LMO7 EPHA2 DLG1 UPF1 USP54	2.05e-07	179	63	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	TC2N TMEM131L TNRC6B HUWE1 HERC1 STAT4	2.19e-07	181	63	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 TC2N LMO7 PKHD1 CRB3 USP54	2.49e-07	185	63	6	3bef59cc0aa939d2a7e52f0f6c61bc00528fe50b
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 TC2N LMO7 PKHD1 CRB3 USP54	2.65e-07	187	63	6	ff26a533d310126521efe1d05cf8b9d32e524550
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	TMEM131L TNRC6B HUWE1 HERC1 MED13L STAT4	2.74e-07	188	63	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 EPHA2 CRB3 USP54	4.79e-06	174	63	5	d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	TNRC6B USP54 TNRC6C HERC1 USP47	5.20e-06	177	63	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	AT1_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	LIPC LMO7 SPTBN1 GAS6 CRB3	5.65e-06	180	63	5	2d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 EPHA2 CRB3 USP54	6.28e-06	184	63	5	d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RELN LIPC PKHD1 DLG1 MED13L	6.45e-06	185	63	5	1d874608aa2062024323512f68889219471b2f00
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 PKHD1 CRB3 USP54	6.45e-06	185	63	5	0c247a3f394c42e2a6f67fee3d9cf33096fecd13
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 LMO7 PKHD1 CRB3 USP54	6.45e-06	185	63	5	c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 EPHA2 CRB3 USP54	6.62e-06	186	63	5	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TC2N LMO7 EPHA2 PKHD1 USP54	7.34e-06	190	63	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	7.34e-06	190	63	5	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TC2N EPHA2 PKHD1 USP54 EDIL3	7.53e-06	191	63	5	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPTBN5 IL31RA ZSCAN20 ANKDD1B CAPS2	7.72e-06	192	63	5	522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCell	proximal-3-Hematologic-Platelet/Megakaryocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPTBN5 IL31RA ZSCAN20 ANKDD1B CAPS2	7.72e-06	192	63	5	f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPTBN5 IL31RA ZSCAN20 ANKDD1B CAPS2	7.72e-06	192	63	5	57899a905ca3e336bb7f31edc6418a2546b9891a
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	7.92e-06	193	63	5	b25cdca3a1e381784ae48ca73c51cbb6ac62b811
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	TNRC6B DLG1 SCAF11 MED13L RFX3	7.92e-06	193	63	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	PCW_13-14-Epithelial-Epithelial_airway\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.12e-06	194	63	5	7b2b40a56eb9c7203ca50133b2da4fd8fdd4a5cf
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.12e-06	194	63	5	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.33e-06	195	63	5	d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.33e-06	195	63	5	d673f8844896d5c7b76a7bc7f6b88a039f1bc263
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.33e-06	195	63	5	ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN CPXM1 CD151 CLEC4M EDIL3	8.54e-06	196	63	5	34e79918a448f6c19b87e1b1ce13c012b24be1f8
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN CPXM1 CD151 CLEC4M EDIL3	8.54e-06	196	63	5	8f82e01ca50aa4cd6149547505b4474a02fad618
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.54e-06	196	63	5	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LMO7 PKHD1 CRB3 CD151 USP54	8.54e-06	196	63	5	784459f9f3614ead947aeb61a873dfd4cbe50641
ToppCell	ASK452-Epithelial-Type_1\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	LMO7 EPHA2 PIEZO1 GAS6 USP54	8.75e-06	197	63	5	dc0a6dca4af6b216357b06f67203274f8b2a8bb0
ToppCell	PCW_13-14-Epithelial\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.97e-06	198	63	5	48eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCell	PCW_10-12-Epithelial-Epithelial_airway\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1 CRB3	8.97e-06	198	63	5	9a12e5e47236433e512c668005fe3f8be6fde95c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN CPXM1 CD151 CLEC4M EDIL3	9.19e-06	199	63	5	b9338b739162cd8e5661c9a4dcb41a31219b5723
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN CPXM1 CD151 CLEC4M EDIL3	9.19e-06	199	63	5	c972d3036151403f26fa9d6271520639c281ab84
ToppCell	ASK452-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	LMO7 PIEZO1 SPTBN1 GAS6 CD151	9.19e-06	199	63	5	48cafe44951908d03f3c6f3e185e9cbb86fb5b3b
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	GRIP1 TNRC6B DLG1 HERC1 MED13L	9.19e-06	199	63	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT1-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N EPHA2 CRB3 USP54	3.69e-05	132	63	4	c6bf0b4b9e33b517629faf4559a21d7ba720ee6a
ToppCell	Mild/Remission-B_intermediate-14\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DNAH10 CPXM1 IRAG1 RFX3	3.91e-05	134	63	4	5bd1e3fa6278facd9e949e9e5e244e700190126b
ToppCell	Mild/Remission-B_intermediate-14\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DNAH10 CPXM1 IRAG1 RFX3	4.77e-05	141	63	4	69e32125a0e8f0c8561e5e7a93607f368f09546f
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 TC2N LMO7 USP54	6.55e-05	153	63	4	e7a074ea8232bacf924be78a244a8507c7e1ebc8
ToppCell	Leuk-UTI-Lymphocyte-T_NK-gdT\|Leuk-UTI / Disease, Lineage and Cell Type	TC2N DNAH10 CLEC4M STAT4	7.42e-05	158	63	4	c4b0af25608cee3d0d2b0193f5ff45d9dc87078b
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	GAS6 ADGRD2 GKN1 ERICH6	7.79e-05	160	63	4	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TC2N SPTBN1 STAT4 DHX9	8.18e-05	162	63	4	80317c4253bf8e897782e562f29835f181c65b98
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	TC2N SPTBN1 TMEM131L TNRC6B	8.18e-05	162	63	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LMO7 MED13L IRAG1 ZDHHC4	9.20e-05	167	63	4	7e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-TRGV5/7_gdT\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTBN5 HERC1 VAV1 STAT4	9.41e-05	168	63	4	235c368669c017e13a7312fce3d8b91d7d106c7a
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIP1 LIPC PKHD1 EDIL3	9.41e-05	168	63	4	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	LMO7 SPTBN1 USP54 RFX2	9.85e-05	170	63	4	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	10x5'-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	GRIP1 CD1D EPHA2 GAS6	1.10e-04	175	63	4	1c48eec300d5a6d4a810947b995af3b8c0a5a601
ToppCell	(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells\|World / Stress and Cell class	CD1D LMO7 GAS6 CPXM1	1.13e-04	176	63	4	ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LMO7 GAS6 PKHD1 CRB3	1.18e-04	178	63	4	f3b5eeca6081d65d48824b5d13e3b8eb5fdeb2dd
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIP1 RELN LIPC PKHD1	1.18e-04	178	63	4	544379f5a6145429762258d426b876bb36c112f5
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	LMO7 SPTBN1 GKN1 ERICH6	1.20e-04	179	63	4	d5763912a4ce7188535675e338799b856edb9dda
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.23e-04	180	63	4	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.25e-04	181	63	4	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ART1 LMO7 PKHD1 USP54	1.25e-04	181	63	4	41969fe4d94ee77b12ecde32170aaf0b13e49644
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ART1 LMO7 PKHD1 USP54	1.25e-04	181	63	4	3f50e61dc2a52d71a5801584617607e6246adcf2
ToppCell	Mesenchymal_cells-Adipo-CAR\|Mesenchymal_cells / Lineage and Cell class	CD1D LMO7 GAS6 CPXM1	1.25e-04	181	63	4	1cfb03eb03a37b036b4eeacec69c9b8163af1ee4
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 PKHD1 CRB3	1.28e-04	182	63	4	cc79e0cc21e2fdc4ef77f052818d27b9f707aec1
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRIP1 LMO7 EPHA2 USP54	1.28e-04	182	63	4	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 EPHA2 USP54	1.28e-04	182	63	4	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N EPHA2 CRB3 USP54	1.31e-04	183	63	4	5f2db95d44b7de68779de098892892af540fd431
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 TC2N PKHD1 CRB3	1.31e-04	183	63	4	274483009b309289e4cb84beedf6806430db6ff6
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N EPHA2 CRB3 USP54	1.31e-04	183	63	4	06ac66726ec53db810ebb90ec69cfdb903da53f6
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 LMO7 PKHD1 CRB3	1.31e-04	183	63	4	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.31e-04	183	63	4	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.34e-04	184	63	4	7cc5796557379c3d1db078c1aeda40659c6e401c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIP1 RELN LIPC PKHD1	1.34e-04	184	63	4	7f6c8912677764d438ab0555faca344d74c2f483
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 PKHD1 CRB3	1.34e-04	184	63	4	cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCell	Control-Epithelial-ATI\|World / Disease state, Lineage and Cell class	LMO7 SPTBN1 GAS6 CRB3	1.36e-04	185	63	4	0563d5042bb96ecce8446fbf26d05ef7a45e23c5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN TC2N DNAH10 EPHA2	1.36e-04	185	63	4	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.36e-04	185	63	4	fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCell	Control-Epithelial_alveolar\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 PKHD1 CRB3 USP54	1.36e-04	185	63	4	3937e026add96a396122139daf8011cfbc60e75c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TC2N TMEM131L TNRC6B STAT4	1.39e-04	186	63	4	9d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TC2N TMEM131L TNRC6B STAT4	1.39e-04	186	63	4	bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 PKHD1 USP54	1.39e-04	186	63	4	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 LMO7 PKHD1 USP54	1.39e-04	186	63	4	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TC2N TMEM131L TNRC6B STAT4	1.39e-04	186	63	4	924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIP1 RELN LIPC PKHD1	1.42e-04	187	63	4	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.42e-04	187	63	4	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1	1.42e-04	187	63	4	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	Control-Epithelial-ATI\|Control / Disease state, Lineage and Cell class	LMO7 SPTBN1 GAS6 CRB3	1.42e-04	187	63	4	fdd1c57b61ca9392ac27661a82729f37593df63c
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|IPF / Disease state, Lineage and Cell class	GRIP1 LMO7 CRB3 EDIL3	1.42e-04	187	63	4	19d6a404fc3651d98a93e3848e372df51a239c57
ToppCell	LPS-IL1RA-Epithelial_alveolar\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.45e-04	188	63	4	6164d467b612767ceba15de34176bcc8e8c36ab8
ToppCell	COPD-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	LMO7 SPTBN1 MED13L EDIL3	1.45e-04	188	63	4	1aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.45e-04	188	63	4	43a0508d2524a5b310e89e9422843dcaab999bc3
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1	1.45e-04	188	63	4	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1	1.45e-04	188	63	4	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	LMO7 TNRC6B RFX3 STAT4	1.45e-04	188	63	4	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1	1.45e-04	188	63	4	3cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N LMO7 CRB3 USP54	1.48e-04	189	63	4	5f883ef4cc0383142d538ae61f4fb40dfdb8ef18
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GRIP1 TC2N LMO7 PKHD1	1.48e-04	189	63	4	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	CD1D LIPC LMO7 CPXM1	1.48e-04	189	63	4	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TC2N LMO7 PKHD1 CRB3	1.48e-04	189	63	4	c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCell	PND10-Epithelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TC2N LMO7 GAS6 CRB3	1.48e-04	189	63	4	89349e226a5512833a94b1bf68056a6985fe4afd
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	LMO7 EPHA2 CRB3 USP54	1.51e-04	190	63	4	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RELN TC2N DLG1 CLEC4M	1.51e-04	190	63	4	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	(1)_Control_(PBS)-(3)_LEPR+_perivascular_cells\|World / Stress and Cell class	CD1D LMO7 GAS6 CPXM1	1.51e-04	190	63	4	ec0ab31266583a0966ac7615d5c0fabb7b7e66e8
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LMO7 SPTBN1 USP54 RFX2	1.51e-04	190	63	4	30b50d183d7649146eb1e79b47ba897355f1998a
Disease	total lipids in small VLDL	LIPC DNAH10 GAS6	3.49e-04	67	60	3	EFO_0022148
Disease	lysophosphatidylcholine 15:0 measurement	LIPC PKHD1	3.64e-04	14	60	2	EFO_0020941
Disease	lymphocyte count	IL31RA LIPC DNAH10 PIEZO1 GAS6 TNRC6B ADGRD2 MED13L GKN1 VAV1	6.84e-04	1464	60	10	EFO_0004587
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	LIPC DNAH10 GAS6	9.69e-04	95	60	3	EFO_0004529, EFO_0008317, EFO_0008596
Disease	obesity (implicated_via_orthology)	LIPC DNAH10 MED13L STAT4	9.71e-04	215	60	4	DOID:9970 (implicated_via_orthology)
Disease	factor VIII measurement, von Willebrand factor measurement	TC2N CLEC4M	1.38e-03	27	60	2	EFO_0004629, EFO_0004630
Disease	susceptibility to urinary tract infection measurement	RELN DLG1 ZKSCAN4	1.40e-03	108	60	3	EFO_0008413
Disease	triglyceride measurement, intermediate density lipoprotein measurement	LIPC DNAH10 GAS6	1.52e-03	111	60	3	EFO_0004530, EFO_0008595
Disease	Ischemic stroke, von Willebrand factor measurement	TC2N CLEC4M	1.71e-03	30	60	2	EFO_0004629, HP_0002140
Disease	resting heart rate, chronic obstructive pulmonary disease	CTAGE1 HERC1	1.71e-03	30	60	2	EFO_0000341, EFO_0004351
Disease	cholesteryl ester measurement	LIPC DNAH10 GAS6 ANKDD1B	1.87e-03	257	60	4	EFO_0010351
Disease	red blood cell density measurement	LIPC DNAH10 PIEZO1 SPTBN1 GAS6 PKHD1 TNRC6B	2.00e-03	880	60	7	EFO_0007978

Protein segments in the cluster

Peptide	Gene	Start	Entry
NVNNWRWTERDATSL	AHSA2P	21	Q719I0
SDQAGNRIRAWNWSN	ERICH6	511	Q7L0X2
QQRWTSESWTNQNSC	CAPS2	46	Q9BXY5
DNWSAAWTAERNLND	CTAGE1	431	Q96RT6
WIVEERADATNVNNW	AHSA1	11	O95433
INASDDEWWQARQVT	DLG1	616	Q12959
SELVGWAEGRWNNQS	CPXM1	416	Q96SM3
WGGEDDDLWNRVQNA	B4GALT5	296	O43286
TWQENTNAWEEEEDA	EBAG9	151	O00559
SEWFNQPWSGEENDN	MED13L	1481	Q71F56
WLRQQGATDWGDTQA	NUDT22	101	Q9BRQ3
SWESVSQATNWTIQQ	IL31RA	371	Q8NI17
WQLTQDSGGWEVQDQ	ATXN8OS	121	P0DMR3
QTNVTSAEGWWEQES	HERC1	3711	Q15751
AQRDSWWSSGLQHEQ	IRAG1	886	Q9Y6F6
WNDGLFDVTWSENNE	PEX7	66	O00628
ENSAVWANVWDTVQT	LIPC	421	P11150
SSNQRRIWGTNVENW	LMO7	356	Q8WWI1
QSNSNNWRWFDDRSG	HUWE1	1611	Q7Z6Z7
SDFENQNGWESDWQE	RELN	1071	P78509
QSSLKDINWDSSQWQ	UPF1	216	Q92900
VWRNHGLWSVDDSQN	CCNYL3	131	P0C7X3
AWTSGHNDQSQWLQV	EDIL3	366	O43854
VDNNNGWDSWNSIWD	GKN1	51	Q9NS71
GTWQTIENATDIWQD	GLP2R	141	O95838
NDWQKNSTRLWNSQS	ERVK-24	391	P61566
NDWQKNSTRLWNSQS	ERVK-7	391	P61567
WWQLQDSNQNTAPDD	ARV1	116	Q9H2C2
WSQGTFSDQQWETLQ	CD1D	71	P15813
SDDQSWGWNLVDNNL	FBXO45	191	P0C2W1
ASDDQTIRVWNWQSR	COPA	111	P53621
NVMSGDQDNWLRTNW	EPHA2	71	P29317
RSWNWLNGEDTTIQE	GAS6	446	Q14393
NDWQKNSTRLWNSQS	ERVK-21	501	P61565
CGSNNSQDWRDSEWI	CD151	156	P48509
SQDWRDSEWIRSQEA	CD151	161	P48509
TWVAHGQTQDWDQER	HELZ2	2041	Q9BYK8
QRSDRQLTWDSWASN	GRIP1	351	Q9Y3R0
ENNQTVWQEWYDLDS	DNAH10	3796	Q8IVF4
HWEENRNENSGNSWN	SCAF11	1046	Q99590
WGRAWGQIQTTSANE	CRB3	21	Q9BUF7
QSNWNPWTSSNIDEG	DHX9	336	Q08211
SQWEDEEGDVWNNAA	TNRC6C	891	Q9HCJ0
WNGSLSLDQSTWNVD	TMEM131L	521	A2VDJ0
WISEDSNNIEAVNQW	TC2N	456	Q8N9U0
AESSWRAQEGQLSWE	NODAL	216	Q96S42
QQQSSLDQWASWLDS	RFX2	576	P48378
QQQSTLEQWAAWLDN	RFX3	561	P48380
IEQNNSWTAENFWLD	SHLD1	66	Q8IYI0
AGWRQEGQDAINVSW	PRR32	116	B1ATL7
DSWEQNRDEGTWQQK	PKHD1	426	P08F94
QAATQAEDWIQAWAQ	SPTBN5	2156	Q9NRC6
VNNRWDVDDWDNENS	SPTBN1	21	Q01082
GQRLSWWQAQESCEQ	ADGRD2	61	Q7Z7M1
EWQRLARSWNFTDDQ	ANKDD1B	441	A6NHY2
SDLNQEGTWQWVDGS	CLEC4M	331	Q9H2X3
QWGNPSQEQWQESSS	ZSCAN20	676	P17040
QWIENQDWEAASNNE	STAT4	36	Q14765
EAEQNWWEGRNTSTN	VAV1	631	P15498
AATNQTTNEWYRGDW	ZDHHC4	281	Q9NPG8
SWVWSQQKEVEQNSG	TRAV12-2	16	A0A075B6T6
GWDSSEAWQQHDVQE	USP47	261	Q96K76
ESWESQGRTESQWEN	ZKSCAN4	466	Q969J2
EQQGRSTAWGLQDWS	STRCP1	1741	A6NGW2
QQWQVFSAERTEEWQ	PIEZO1	1111	Q92508
DSWDNNNRSTGGSWN	TNRC6B	471	Q9UPQ9
SRTDNSWAPWSETNQ	USP54	1536	Q70EL1
ADSWTLASSQWQERQ	ART1	76	P52961