Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

TUBG2 TUBG1 TUBGCP3

3.29e-04130213GO:0005200
GeneOntologyBiologicalProcessorganelle fission

SLC25A46 ASPM TUBG2 MEIOSIN TUBG1 RIPOR2 MCU CLTC

4.86e-08571218GO:0048285
GeneOntologyBiologicalProcessspindle organization

ASPM TUBG2 TUBG1 RIPOR2 TUBGCP3 CLTC

7.27e-08224216GO:0007051
GeneOntologyBiologicalProcesschromosome segregation

ASPM TUBG2 TOP3B TUBG1 RIPOR2 TUBGCP3 CLTC

2.50e-07465217GO:0007059
GeneOntologyBiologicalProcesspositive regulation of neutrophil chemotaxis

RIPOR2 MCU NCKAP1L

4.43e-0632213GO:0090023
GeneOntologyBiologicalProcesspositive regulation of granulocyte chemotaxis

RIPOR2 MCU NCKAP1L

6.36e-0636213GO:0071624
GeneOntologyBiologicalProcessmeiotic spindle organization

ASPM TUBG2 TUBG1

6.91e-0637213GO:0000212
GeneOntologyBiologicalProcessnuclear division

ASPM TUBG2 MEIOSIN TUBG1 RIPOR2 CLTC

8.98e-06512216GO:0000280
GeneOntologyBiologicalProcessregulation of neutrophil chemotaxis

RIPOR2 MCU NCKAP1L

9.46e-0641213GO:0090022
GeneOntologyBiologicalProcesspositive regulation of neutrophil migration

RIPOR2 MCU NCKAP1L

1.43e-0547213GO:1902624
GeneOntologyBiologicalProcessmitotic spindle organization

TUBG2 TUBG1 RIPOR2 CLTC

1.50e-05151214GO:0007052
GeneOntologyBiologicalProcessspindle assembly

ASPM RIPOR2 TUBGCP3 CLTC

1.58e-05153214GO:0051225
GeneOntologyBiologicalProcessmeiotic cell cycle

ASPM TUBG2 MEIOSIN TUBG1 TUBGCP3

2.22e-05350215GO:0051321
GeneOntologyBiologicalProcessnuclear chromosome segregation

ASPM TUBG2 TUBG1 RIPOR2 CLTC

2.41e-05356215GO:0098813
GeneOntologyBiologicalProcessmicrotubule nucleation

TUBG2 TUBG1 TUBGCP3

2.57e-0557213GO:0007020
GeneOntologyBiologicalProcessregulation of neutrophil migration

RIPOR2 MCU NCKAP1L

2.85e-0559213GO:1902622
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization involved in mitosis

TUBG2 TUBG1 RIPOR2 CLTC

3.47e-05187214GO:1902850
GeneOntologyBiologicalProcessregulation of granulocyte chemotaxis

RIPOR2 MCU NCKAP1L

3.81e-0565213GO:0071622
GeneOntologyBiologicalProcesscytoplasmic microtubule organization

TUBG2 TUBG1 TUBGCP3

3.99e-0566213GO:0031122
GeneOntologyBiologicalProcesscell cycle process

ASPM TUBG2 TOP3B MEIOSIN TUBG1 RIPOR2 TUBGCP3 CLTC

4.97e-051441218GO:0022402
GeneOntologyBiologicalProcessmicrotubule-based process

ASPM TUBG2 TUBG1 RIPOR2 TUBGCP3 CLTC VPS13A

5.65e-051058217GO:0007017
GeneOntologyBiologicalProcessmitotic sister chromatid segregation

TUBG2 TUBG1 RIPOR2 CLTC

5.66e-05212214GO:0000070
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

ASPM TUBG2 TUBG1 RIPOR2 TUBGCP3 CLTC

6.14e-05720216GO:0000226
GeneOntologyBiologicalProcesssister chromatid segregation

TUBG2 TUBG1 RIPOR2 CLTC

1.14e-04254214GO:0000819
GeneOntologyBiologicalProcessmeiotic cell cycle process

ASPM TUBG2 MEIOSIN TUBG1

1.40e-04268214GO:1903046
GeneOntologyBiologicalProcessneutrophil chemotaxis

RIPOR2 MCU NCKAP1L

1.46e-04102213GO:0030593
GeneOntologyBiologicalProcesspositive regulation of leukocyte chemotaxis

RIPOR2 MCU NCKAP1L

1.78e-04109213GO:0002690
GeneOntologyBiologicalProcessmicrotubule polymerization

TUBG2 TUBG1 TUBGCP3

2.20e-04117213GO:0046785
GeneOntologyBiologicalProcessmitotic nuclear division

TUBG2 TUBG1 RIPOR2 CLTC

2.63e-04316214GO:0140014
GeneOntologyBiologicalProcessneutrophil migration

RIPOR2 MCU NCKAP1L

2.99e-04130213GO:1990266
GeneOntologyBiologicalProcessprotein polymerization

TUBG2 TUBG1 TUBGCP3 NCKAP1L

3.25e-04334214GO:0051258
GeneOntologyBiologicalProcessregulation of leukocyte chemotaxis

RIPOR2 MCU NCKAP1L

3.96e-04143213GO:0002688
GeneOntologyBiologicalProcessgranulocyte chemotaxis

RIPOR2 MCU NCKAP1L

4.21e-04146213GO:0071621
GeneOntologyBiologicalProcesschromosome organization

TUBG2 TOP3B TUBG1 RIPOR2 CLTC

5.24e-04686215GO:0051276
GeneOntologyBiologicalProcesspositive regulation of chemotaxis

RIPOR2 MCU NCKAP1L

6.12e-04166213GO:0050921
GeneOntologyBiologicalProcessmicrotubule polymerization or depolymerization

TUBG2 TUBG1 TUBGCP3

6.34e-04168213GO:0031109
GeneOntologyBiologicalProcesspositive regulation of leukocyte migration

RIPOR2 MCU NCKAP1L

7.62e-04179213GO:0002687
GeneOntologyBiologicalProcessgranulocyte migration

RIPOR2 MCU NCKAP1L

7.74e-04180213GO:0097530
GeneOntologyBiologicalProcessregulation of mitotic spindle organization

RIPOR2 CLTC

9.10e-0444212GO:0060236
GeneOntologyBiologicalProcessregulation of spindle organization

RIPOR2 CLTC

1.08e-0348212GO:0090224
GeneOntologyBiologicalProcessmembraneless organelle assembly

ASPM RIPOR2 TUBGCP3 CLTC

1.22e-03475214GO:0140694
GeneOntologyBiologicalProcessmitochondrial fission

SLC25A46 MCU

1.22e-0351212GO:0000266
GeneOntologyBiologicalProcessclathrin-dependent endocytosis

CLTC STON1

1.32e-0353212GO:0072583
GeneOntologyBiologicalProcessregulation of organelle organization

MEIOSIN TUBG1 RIPOR2 MCU CLTC NCKAP1L

1.74e-031342216GO:0033043
GeneOntologyBiologicalProcessregulation of chemotaxis

RIPOR2 MCU NCKAP1L

1.81e-03242213GO:0050920
GeneOntologyBiologicalProcessnegative regulation of protein localization

MARK3 RIPOR2 CLTC

2.30e-03263213GO:1903828
GeneOntologyBiologicalProcessregulation of leukocyte migration

RIPOR2 MCU NCKAP1L

2.40e-03267213GO:0002685
GeneOntologyBiologicalProcessleukocyte chemotaxis

RIPOR2 MCU NCKAP1L

2.40e-03267213GO:0030595
GeneOntologyBiologicalProcesscellular response to retinoic acid

MEIOSIN RORB

2.48e-0373212GO:0071300
GeneOntologyBiologicalProcessmyeloid leukocyte migration

RIPOR2 MCU NCKAP1L

2.64e-03276213GO:0097529
GeneOntologyBiologicalProcessmitotic cell cycle

TUBG2 TUBG1 RIPOR2 TUBGCP3 CLTC

2.99e-031014215GO:0000278
GeneOntologyBiologicalProcessregulation of meiotic cell cycle

ASPM MEIOSIN

3.12e-0382212GO:0051445
GeneOntologyCellularComponentgamma-tubulin complex

TUBG2 TUBG1 TUBGCP3

1.33e-0621223GO:0000930
GeneOntologyCellularComponentspindle microtubule

TUBG2 TUBG1 TUBGCP3 CLTC

1.85e-0686224GO:0005876
GeneOntologyCellularComponentpolar microtubule

TUBG1 TUBGCP3

1.06e-055222GO:0005827
GeneOntologyCellularComponentmitotic spindle microtubule

TUBG1 CLTC

9.55e-0514222GO:1990498
GeneOntologyCellularComponentspindle

ASPM TUBG2 TUBG1 TUBGCP3 CLTC

1.09e-04471225GO:0005819
GeneOntologyCellularComponentmicrotubule

ASPM TUBG2 TUBG1 TUBGCP3 CLTC

1.94e-04533225GO:0005874
GeneOntologyCellularComponentclathrin coat of coated pit

CLTC STON1

2.19e-0421222GO:0030132
GeneOntologyCellularComponentpericentriolar material

TUBG2 TUBG1

3.93e-0428222GO:0000242
GeneOntologyCellularComponentclathrin vesicle coat

CLTC STON1

7.26e-0438222GO:0030125
GeneOntologyCellularComponentmitotic spindle

ASPM TUBG1 CLTC

1.18e-03201223GO:0072686
GeneOntologyCellularComponentspindle pole

ASPM TUBG1 TUBGCP3

1.25e-03205223GO:0000922
GeneOntologyCellularComponentclathrin coat

CLTC STON1

1.57e-0356222GO:0030118
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

ASPM TUBG2 TUBG1 TUBGCP3 CLTC

2.08e-03899225GO:0099513
GeneOntologyCellularComponentvesicle coat

CLTC STON1

2.24e-0367222GO:0030120
GeneOntologyCellularComponentclathrin-coated endocytic vesicle membrane

CLTC STON1

3.10e-0379222GO:0030669
GeneOntologyCellularComponentclathrin-coated pit

CLTC STON1

3.18e-0380222GO:0005905
GeneOntologyCellularComponentclathrin-coated endocytic vesicle

CLTC STON1

5.01e-03101222GO:0045334
GeneOntologyCellularComponentmembrane coat

CLTC STON1

5.51e-03106222GO:0030117
GeneOntologyCellularComponentcoated membrane

CLTC STON1

5.51e-03106222GO:0048475
GeneOntologyCellularComponentsupramolecular fiber

ASPM TUBG2 TUBG1 TUBGCP3 CLTC

6.66e-031179225GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

ASPM TUBG2 TUBG1 TUBGCP3 CLTC

6.85e-031187225GO:0099081
GeneOntologyCellularComponentcentrosome

ASPM TUBG2 TUBG1 TUBGCP3

7.87e-03770224GO:0005813
GeneOntologyCellularComponentcytoplasmic microtubule

TUBG2 TUBG1

8.54e-03133222GO:0005881
HumanPhenoAbnormally slow thought process

CLTC VPS13A

5.18e-056102HP:0031843
MousePhenoacanthocytosis

VPS13A NCKAP1L

7.61e-0511172MP:0010177
MousePhenodecreased amacrine cell number

SLC25A46 RORB

9.12e-0512172MP:0008106
MousePhenodecreased spinal cord size

SLC25A46 VIT

1.08e-0413172MP:0000956
MousePhenoabnormal amacrine cell number

SLC25A46 RORB

1.65e-0416172MP:0008104
MousePhenoincreased erythrocyte osmotic fragility

VPS13A NCKAP1L

2.11e-0418172MP:0031085
DomainGamma_tubulin

TUBG2 TUBG1

1.20e-062212IPR002454
Domain-

TUBG2 TUBG1

2.26e-04202123.30.1330.20
Domain-

TUBG2 TUBG1

2.50e-04212121.10.287.600
DomainTubulin/FtsZ_2-layer-sand-dom

TUBG2 TUBG1

2.74e-0422212IPR018316
DomainTubulin_C

TUBG2 TUBG1

2.74e-0422212SM00865
Domain-

TUBG2 TUBG1

2.74e-04222123.40.50.1440
DomainTubulin_C

TUBG2 TUBG1

2.74e-0422212PF03953
DomainTubulin_C

TUBG2 TUBG1

3.00e-0423212IPR023123
DomainTUBULIN

TUBG2 TUBG1

3.00e-0423212PS00227
DomainTubulin

TUBG2 TUBG1

3.00e-0423212IPR000217
DomainTub_FtsZ_C

TUBG2 TUBG1

3.00e-0423212IPR008280
DomainTubulin

TUBG2 TUBG1

3.00e-0423212SM00864
DomainTubulin_CS

TUBG2 TUBG1

3.00e-0423212IPR017975
DomainTubulin_FtsZ_GTPase

TUBG2 TUBG1

3.27e-0424212IPR003008
DomainTubulin

TUBG2 TUBG1

3.27e-0424212PF00091
DomainARM-type_fold

ASPM RIPOR2 CLTC

6.19e-03339213IPR016024
PathwayREACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES

TUBG2 TUBG1 TUBGCP3

6.36e-0581143M748
PathwayREACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES

TUBG2 TUBG1 TUBGCP3

8.71e-0590143MM14979
PathwayREACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES

TUBG2 TUBG1 TUBGCP3

1.02e-0495143M6729
PathwayREACTOME_MITOTIC_G2_G2_M_PHASES

TUBG2 TUBG1 TUBGCP3

7.16e-04184143MM15145
PathwayREACTOME_MITOTIC_G2_G2_M_PHASES

TUBG2 TUBG1 TUBGCP3

9.12e-04200143M864
PathwayREACTOME_MITOTIC_PROMETAPHASE

TUBG2 TUBG1 TUBGCP3

9.39e-04202143MM15362
PathwayREACTOME_MITOTIC_PROMETAPHASE

TUBG2 TUBG1 TUBGCP3

9.66e-04204143M4217
Pubmed

Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.

TUBG2 TUBG1 TUBGCP3

2.53e-1032339566969
Pubmed

Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.

ASPM TUBG2 TUBG1

1.01e-09423316798874
Pubmed

The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors.

TUBG2 TUBG1 TUBGCP3

1.41e-08823338086550
Pubmed

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

ASPM TUBG2 TUBG1

1.41e-08823327562601
Pubmed

Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.

TUBG2 TUBG1 TUBGCP3

2.12e-08923311956313
Pubmed

Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis.

TUBG2 TUBG1 TUBGCP3

2.12e-0892338838651
Pubmed

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.

ASPM TUBG2 TUBG1

5.54e-081223320823249
Pubmed

Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.

TUBG2 RORB TUBG1

1.14e-071523332097653
Pubmed

Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.

ASPM TUBG2 TUBG1

2.86e-072023334237032
Pubmed

Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.

TUBG2 TUBG1

4.18e-07223228119396
Pubmed

Overexpression of γ-tubulin in non-small cell lung cancer.

TUBG2 TUBG1

4.18e-07223222806905
Pubmed

Gene knockout analysis of two gamma-tubulin isoforms in mice.

TUBG2 TUBG1

4.18e-07223215893303
Pubmed

Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.

TUBG2 TUBG1

4.18e-07223217287496
Pubmed

MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.

TUBG2 TUBG1

4.18e-07223217442887
Pubmed

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.

TUBG2 TUBG1 CLTC

8.19e-072823326884322
Pubmed

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex.

TUBG1 TUBGCP3

1.25e-06323217959831
Pubmed

The gamma-tubulin gene family in humans.

TUBG2 TUBG1

1.25e-06323210903841
Pubmed

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

TUBG2 TUBG1

1.25e-06323226021315
Pubmed

Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.

TUBG2 TUBG1

1.25e-06323227015882
Pubmed

Cilia organize ependymal planar polarity.

TUBG2 TUBG1

2.51e-06423220164345
Pubmed

Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.

TUBG2 TUBG1

2.51e-06423236574677
Pubmed

Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus.

TUBG1 TUBGCP3

2.51e-06423219299467
Pubmed

Loss of Necdin impairs myosin activation and delays cell polarization.

TUBG2 TUBG1

2.51e-06423220665884
Pubmed

TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia.

TUBG1 TUBGCP3 CLTC

2.65e-064123319786618
Pubmed

Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium.

TUBG2 TUBG1

4.18e-06523221285373
Pubmed

Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease.

TUBG2 TUBG1

4.18e-06523219251731
Pubmed

The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.

TUBG2 TUBG1

4.18e-06523221529752
Pubmed

Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.

TUBG2 TUBG1

4.18e-06523218729223
Pubmed

Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.

TUBG2 TUBG1

4.18e-06523229244804
Pubmed

A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos.

TUBG2 TUBG1

4.18e-06523215680357
Pubmed

Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.

TUBG2 TUBG1

4.18e-06523225877302
Pubmed

HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.

TUBG2 TUBG1

4.18e-06523214767062
Pubmed

Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.

TUBG2 TUBG1

4.18e-06523231390572
Pubmed

WDR62 is associated with the spindle pole and is mutated in human microcephaly.

TUBG2 TUBG1

4.18e-06523220890279
Pubmed

Speriolin is a novel human and mouse sperm centrosome protein.

TUBG2 TUBG1

4.18e-06523220542897
Pubmed

A two-kinesin mechanism controls neurogenesis in the developing brain.

TUBG2 TUBG1

4.18e-06523238040957
Pubmed

Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.

TUBG2 TUBG1

4.18e-06523216751367
Pubmed

Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.

TUBG1 TUBGCP3 CLTC

5.47e-065223320114047
Pubmed

The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP.

TUBG2 TUBG1

6.26e-06623238546045
Pubmed

A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.

TUBG2 TUBG1

6.26e-06623211237715
Pubmed

Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.

TUBG2 TUBG1

6.26e-06623230970247
Pubmed

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.

TUBG2 TUBG1

6.26e-06623222842144
Pubmed

Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.

TUBG2 TUBG1

6.26e-06623210840040
Pubmed

Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.

TUBG2 TUBG1

6.26e-06623229229864
Pubmed

Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development.

TUBG2 TUBG1

6.26e-06623235259752
Pubmed

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.

TUBG2 TUBG1

6.26e-06623236334595
Pubmed

TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.

TUBG2 TUBG1

8.77e-06723238261656
Pubmed

The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.

TUBG2 TUBG1

8.77e-06723229372668
Pubmed

A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return.

TUBG2 TUBG1

8.77e-06723230289203
Pubmed

PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.

TUBG2 TUBG1

8.77e-06723238827526
Pubmed

Mammalian RanBP1 regulates centrosome cohesion during mitosis.

TUBG2 TUBG1

8.77e-06723212840069
Pubmed

Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.

TUBG2 TUBG1

8.77e-06723222902295
Pubmed

AIRE is a critical spindle-associated protein in embryonic stem cells.

TUBG2 TUBG1

8.77e-06723228742026
Pubmed

HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.

TUBG2 TUBG1

8.77e-06723229724823
Pubmed

Pax6 controls centriole maturation in cortical progenitors through Odf2.

TUBG2 TUBG1

8.77e-06723225352170
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

TUBG1 TUBGCP3 CLTC

9.78e-066323329162697
Pubmed

Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.

TUBG2 TUBG1 TUBGCP3

1.12e-056623312221128
Pubmed

A ciliopathy complex builds distal appendages to initiate ciliogenesis.

TUBG2 TUBG1

1.17e-05823234241634
Pubmed

The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.

TUBG2 TUBG1

1.17e-05823219112494
Pubmed

Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.

TUBG2 TUBG1

1.17e-05823218239929
Pubmed

A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development.

TUBG2 TUBG1

1.17e-05823215958512
Pubmed

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.

TUBG2 TUBG1

1.17e-05823226540106
Pubmed

Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.

TUBG2 TUBG1

1.17e-05823227727273
Pubmed

Rack1 regulates cellular patterning and polarity in the mouse cochlea.

TUBG2 TUBG1

1.17e-05823236252648
Pubmed

The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.

TUBG1 TUBGCP3

1.17e-05823224509916
Pubmed

A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.

TUBG2 TUBG1

1.17e-05823217908927
Pubmed

Ciliary proteins link basal body polarization to planar cell polarity regulation.

TUBG2 TUBG1

1.50e-05923218066062
Pubmed

Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus.

TUBG2 TUBG1

1.50e-05923214667810
Pubmed

Autonomous and non-cell autonomous role of cilia in structural birth defects in mice.

TUBG2 TUBG1

1.50e-05923238079449
Pubmed

Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.

TUBG2 TUBG1

1.50e-05923230532139
Pubmed

TRIP6 functions in brain ciliogenesis.

TUBG2 TUBG1

1.50e-05923234620853
Pubmed

TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.

TUBG2 TUBG1

1.50e-05923231086189
Pubmed

Centriolar Protein C2cd3 Is Required for Craniofacial Development.

TUBG2 TUBG1

1.50e-05923234211969
Pubmed

MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.

TUBG2 TUBG1

1.50e-05923221397847
Pubmed

Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.

TUBG2 TUBG1

1.50e-05923230824354
Pubmed

Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1.

TUBG2 TUBG1

1.88e-051023220592197
Pubmed

A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.

TUBG2 TUBG1

1.88e-051023225220058
Pubmed

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.

CLTC STON1

1.88e-051023226437238
Pubmed

A role for primary cilia in aortic valve development and disease.

TUBG2 TUBG1

1.88e-051023228556366
Pubmed

CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex.

TUBG1 TUBGCP3

1.88e-051023221135143
Pubmed

GemC1 controls multiciliogenesis in the airway epithelium.

TUBG2 TUBG1

1.88e-051023226882546
Pubmed

Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.

TUBG2 TUBG1

1.88e-051023226748089
Pubmed

Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells.

TUBG2 TUBG1

1.88e-051023222479190
Pubmed

DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.

TUBG2 TUBG1

2.29e-051123233811421
Pubmed

Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects.

TUBG2 TUBG1

2.29e-051123234274973
Pubmed

Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome.

TUBG2 TUBG1

2.29e-051123219279158
Pubmed

Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development.

TUBG2 TUBG1

2.29e-051123238658571
Pubmed

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.

TUBG2 TUBG1

2.29e-051123229229923
Pubmed

The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.

TUBG2 TUBG1

2.29e-051123218364031
Pubmed

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.

TUBG2 TUBG1

2.29e-051123228291807
Pubmed

An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling.

TUBG2 TUBG1

2.29e-051123229021239
Pubmed

Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex.

TUBG2 TUBG1

2.29e-051123231794381
Pubmed

Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development.

TUBG2 TUBG1

2.29e-051123233410253
Pubmed

HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.

TUBG2 TUBG1

2.29e-051123228994651
Pubmed

A dual role for planar cell polarity genes in ciliated cells.

TUBG2 TUBG1

2.29e-051123225024228
Pubmed

Primary cilia are critical for tracheoesophageal septation.

TUBG2 TUBG1

2.29e-051123237776236
Pubmed

Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.

TUBG2 TUBG1

2.75e-051223234427181
Pubmed

Nubp2 is required for cranial neural crest survival in the mouse.

TUBG2 TUBG1

2.75e-051223231733190
Pubmed

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice.

TUBG2 TUBG1

2.75e-051223229317443
Pubmed

Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate.

TUBG2 TUBG1

2.75e-051223228069795
InteractionTUBGCP5 interactions

ASPM TUBG2 TRIM66 TUBG1 TUBGCP3

2.47e-0955215int:TUBGCP5
InteractionTUBGCP6 interactions

TUBG2 TRIM66 TUBG1 TUBGCP3

4.99e-0763214int:TUBGCP6
InteractionTUBGCP2 interactions

TUBG2 TRIM66 TUBG1 GPR17 TUBGCP3

8.72e-07176215int:TUBGCP2
InteractionMZT2B interactions

TUBG2 TUBG1 GPR17 TUBGCP3

9.56e-0774214int:MZT2B
InteractionMARK4 interactions

TRIM66 MARK3 TOP3B TUBG1

1.52e-0683214int:MARK4
InteractionMZT2A interactions

TUBG2 TUBG1 TUBGCP3

1.70e-0623213int:MZT2A
InteractionTUBG2 interactions

TUBG2 TUBG1 TUBGCP3

7.41e-0637213int:TUBG2
InteractionRPL27AP6 interactions

TUBG1 TUBGCP3

1.55e-056212int:RPL27AP6
InteractionAHCTF1 interactions

SLC25A46 TRIM66 TUBG1 TUBGCP3

1.60e-05150214int:AHCTF1
InteractionRHOC interactions

MARK3 TOP3B RIPOR2 MCU CLTC VPS13A

2.16e-05584216int:RHOC
InteractionTUBGCP4 interactions

TUBG2 TUBG1 GPR17 TUBGCP3

2.56e-05169214int:TUBGCP4
InteractionSEC16A interactions

SLC25A46 TRIM66 TOP3B TUBG1 CLTC

6.34e-05426215int:SEC16A
InteractionSV2A interactions

SLC25A46 TRIM66 MCU

7.33e-0579213int:SV2A
InteractionPDCD1 interactions

SLC25A46 MCU TUBGCP3

7.61e-0580213int:PDCD1
InteractionTUBGCP3 interactions

TUBG2 TRIM66 TUBG1 TUBGCP3

8.35e-05229214int:TUBGCP3
InteractionPLEKHA2 interactions

TUBG1 TUBGCP3 CLTC

1.23e-0494213int:PLEKHA2
InteractionRHOA interactions

MARK3 TOP3B ACOT9 RIPOR2 MCU CLTC VPS13A

1.44e-041199217int:RHOA
InteractionSLC25A46 interactions

SLC25A46 GPR17 CLTC VPS13A

1.51e-04267214int:SLC25A46
InteractionCMKLR1 interactions

SLC25A46 MCU TUBGCP3

1.52e-04101213int:CMKLR1
InteractionMUL1 interactions

SLC25A46 GPR17 TUBGCP3

1.52e-04101213int:MUL1
InteractionWDFY3 interactions

TRIM66 TOP3B GPR17

1.61e-04103213int:WDFY3
InteractionMTCL2 interactions

TRIM66 MARK3 RORB

2.18e-04114213int:MTCL2
InteractionTHADA interactions

TRIM66 TOP3B GPR17

2.29e-04116213int:THADA
InteractionLRWD1 interactions

TOP3B TUBG1 TUBGCP3

2.41e-04118213int:LRWD1
InteractionITPR2 interactions

SLC25A46 TOP3B GPR17

2.59e-04121213int:ITPR2
InteractionSLC37A3 interactions

SLC25A46 TOP3B

3.06e-0425212int:SLC37A3
InteractionSLC5A8 interactions

SLC25A46 MCU

3.31e-0426212int:SLC5A8
InteractionPXN interactions

TUBG2 TOP3B TUBG1 CLTC

3.55e-04334214int:PXN
InteractionRNF19A interactions

TUBG2 TUBG1

3.57e-0427212int:RNF19A
InteractionCRTAC1 interactions

ASPM VPS13A

3.57e-0427212int:CRTAC1
InteractionSLC22A6 interactions

SLC25A46 MCU

3.85e-0428212int:SLC22A6
InteractionFAM83H interactions

TRIM66 TOP3B CLTC

4.07e-04141213int:FAM83H
InteractionSPEG interactions

ASPM TOP3B

4.13e-0429212int:SPEG
InteractionMRPS7 interactions

TOP3B TUBG1 MCU TUBGCP3

4.47e-04355214int:MRPS7
InteractionMFN2 interactions

SLC25A46 TOP3B CLTC

4.68e-04148213int:MFN2
InteractionTPCN1 interactions

TOP3B GPR17

4.72e-0431212int:TPCN1
InteractionTOMM22 interactions

SLC25A46 TOP3B CLTC VPS13A

5.12e-04368214int:TOMM22
InteractionPER2 interactions

ASPM TOP3B CLTC

5.16e-04153213int:PER2
InteractionRHOF interactions

MARK3 TOP3B MCU CLTC VPS13A

5.34e-04673215int:RHOF
InteractionMFSD12 interactions

TOP3B GPR17

5.69e-0434212int:MFSD12
InteractionUBA1 interactions

TUBG2 ACOT9 TUBGCP3 CLTC

5.78e-04380214int:UBA1
InteractionNME7 interactions

TUBG2 TUBG1 TUBGCP3

5.88e-04160213int:NME7
InteractionTUBG1 interactions

TUBG2 TOP3B TUBG1 TUBGCP3

5.89e-04382214int:TUBG1
InteractionVEZT interactions

SLC25A46 TRIM66 GPR17

6.10e-04162213int:VEZT
InteractionPPP6R1 interactions

TRIM66 TOP3B GPR17

6.55e-04166213int:PPP6R1
InteractionFANCA interactions

TOP3B TUBG1 GPR17

6.66e-04167213int:FANCA
InteractionGARRE1 interactions

ASPM TRIM66 MARK3

6.66e-04167213int:GARRE1
InteractionIQCE interactions

ASPM TOP3B

6.74e-0437212int:IQCE
InteractionLRBA interactions

TOP3B GPR17 CLTC

7.01e-04170213int:LRBA
InteractionPNPLA2 interactions

MARK3 TOP3B

7.11e-0438212int:PNPLA2
InteractionFBXO6 interactions

TUBG2 ACOT9 FRAS1 TUBG1 CLTC

7.12e-04717215int:FBXO6
InteractionHAX1 interactions

SLC25A46 TUBGCP3 CLTC VPS13A

7.27e-04404214int:HAX1
Cytoband17q21

TUBG2 TUBG1

4.60e-046323217q21
CytobandEnsembl 112 genes in cytogenetic band chr9q21

RORB VPS13A

4.45e-03199232chr9q21
CytobandEnsembl 112 genes in cytogenetic band chr17q21

TUBG2 TUBG1

2.32e-02473232chr17q21
GeneFamilyTubulins

TUBG2 TUBG1

5.54e-052682778
CoexpressionGSE22443_NAIVE_VS_ACT_AND_IL12_TREATED_CD8_TCELL_DN

TRIM66 TOP3B RIPOR2 CLTC

1.78e-05200214M8225
Diseasecomplex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)

TUBG2 TUBG1

5.31e-072222DOID:0090138 (implicated_via_orthology)
DiseasePrimary microcephaly

ASPM TUBGCP3

1.21e-0422222C0431350
Diseasemean reticulocyte volume

MARK3 RIPOR2 STON1 VPS13A

2.65e-03799224EFO_0010701
Diseasemortality

SLC25A46 VPS13A

7.31e-03173222EFO_0004352
Diseasecortical thickness

MARK3 RIPOR2 VIT STON1

8.56e-031113224EFO_0004840
Diseasemacula measurement

RORB STON1

8.67e-03189222EFO_0008375
Diseasebrain volume measurement

FRAS1 VIT STON1

9.44e-03595223EFO_0006930

Protein segments in the cluster

PeptideGeneStartEntry
VQTNHTVVCLQLYRE

GPR17

201

Q13304
VCFTQNNYIQVRVHS

ACOT9

361

Q9Y305
QLQRQHKCAIIIQSY

ASPM

1966

Q8IZT6
HQRQVYLQIRSSVII

ASPM

2901

Q8IZT6
NVNRHYCTVRNVNIL

FRAS1

3961

Q86XX4
TLVQQLYTTLCIEQH

MCU

181

Q8NE86
LQTVIYRLIVQIQHL

LUZP6

31

Q538Z0
IQQIIDHQYCIQSLQ

MYRFL

776

Q96LU7
YNNNIHCLTKAIIQV

NCKAP1L

1026

P55160
QLRILTHFYQGIVQQ

TUBGCP3

846

Q96CW5
LVHVLQYIQYLQRNI

MEIOSIN

106

C9JSJ3
QIVSAVQYCHQKRIV

MARK3

161

P27448
VRHLQYCTQLVQQIV

RIPOR2

746

Q9Y4F9
RQNLQICVQVASKYH

CLTC

676

Q00610
VHINNICQRNYVTVE

TOP3B

516

O95985
QIYRIQIQNQIHGAV

VPS13A

2646

Q96RL7
VQPQKHVQQRACYNI

STON1

696

Q9Y6Q2
HVQQRACYNIQVEIE

STON1

701

Q9Y6Q2
RQTNHCYIAILNIIQ

TUBG1

311

P23258
IVLRRQCQVNYHAQH

SLC25A46

121

Q96AG3
QQCAIQITHAIQYVV

RORB

271

Q92753
NLHQYVPRIIQNICT

VIT

656

Q6UXI7
ECQLYLRHSQQQQVL

SNURFL

36

B1AK76
RQTNHCYIAILNIIQ

TUBG2

311

Q9NRH3
QHLQQTIVGQINYIV

TRIM66

541

O15016