Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sterol response element binding	SREBF1 SMAD3	5.74e-05	3	88	2	GO:0032810
MousePheno	increased response of heart to induced stress	THBS4 ABCB10 DSP OBSCN ADAMTSL3	5.62e-06	53	68	5	MP:0004485
Domain	-	LRIG2 TRIL KCTD9 NOD1 FBXL14 NRROS SKP2 NLRC4 PHLPP2 NLRP13	2.99e-06	321	89	10	3.80.10.10
Domain	L_dom-like	LRIG2 TRIL KCTD9 NOD1 FBXL14 NRROS SKP2 NLRC4 PHLPP2 NLRP13	3.62e-06	328	89	10	IPR032675
Domain	DVL-1	DVL1P1 DVL1	2.25e-05	2	89	2	IPR008340
Domain	GREB1	GREB1L GREB1	2.25e-05	2	89	2	PF15782
Domain	GREB1	GREB1L GREB1	2.25e-05	2	89	2	IPR028422
Domain	Leu-rich_rpt	LRIG2 TRIL NOD1 FBXL14 NRROS SKP2 PHLPP2 NLRP13	4.53e-05	271	89	8	IPR001611
Domain	-	NWD2 NOD1 ABCB10 SLFN13 DNM3 PSMC6 SLFN11 ABCC2 SMC2 DHX34 DICER1 NLRC4 NLRP13	5.06e-05	746	89	13	3.40.50.300
Domain	DUF2075	SLFN13 SLFN11	6.72e-05	3	89	2	IPR018647
Domain	DUF2075	SLFN13 SLFN11	6.72e-05	3	89	2	PF09848
Domain	Dishevelled_fam	DVL1P1 DVL1	1.34e-04	4	89	2	IPR008339
Domain	Dishevelled	DVL1P1 DVL1	1.34e-04	4	89	2	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	1.34e-04	4	89	2	IPR003351
Domain	LRR_6	NOD1 FBXL14 NRROS NLRP13	1.36e-04	55	89	4	PF13516
Domain	TPR_REGION	SPAG1 TTC16 P4HA3 TTC39A CABIN1 TTC3	1.38e-04	165	89	6	PS50293
Domain	TPR	SPAG1 TTC16 P4HA3 TTC39A CABIN1 TTC3	1.38e-04	165	89	6	PS50005
Domain	NACHT	NOD1 NLRC4 NLRP13	1.73e-04	23	89	3	PS50837
Domain	NACHT_NTPase	NOD1 NLRC4 NLRP13	1.73e-04	23	89	3	IPR007111
Domain	P-loop_NTPase	NWD2 NOD1 ABCB10 SLFN13 DNM3 PSMC6 SLFN11 ABCC2 SMC2 DHX34 DICER1 NLRC4 NLRP13	1.83e-04	848	89	13	IPR027417
Domain	PH_dom-like	SPTBN5 TLN1 FRMPD1 ASAP3 OBSCN DNM3 CIT PHLPP2 ANKS1A	1.95e-04	426	89	9	IPR011993
Domain	TPR	SPAG1 TTC16 TTC39A CABIN1 TTC3	3.80e-04	129	89	5	SM00028
Domain	TPR_repeat	SPAG1 TTC16 TTC39A CABIN1 TTC3	4.37e-04	133	89	5	IPR019734
Domain	DIX	DVL1P1 DVL1	4.64e-04	7	89	2	PF00778
Domain	AlbA_2	SLFN13 SLFN11	4.64e-04	7	89	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	4.64e-04	7	89	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	4.64e-04	7	89	2	IPR007421
Domain	DIX	DVL1P1 DVL1	4.64e-04	7	89	2	IPR001158
Domain	DIX	DVL1P1 DVL1	4.64e-04	7	89	2	PS50841
Domain	DAX	DVL1P1 DVL1	4.64e-04	7	89	2	SM00021
Domain	-	SPAG1 TTC16 P4HA3 TTC39A CABIN1 TTC3	4.66e-04	207	89	6	1.25.40.10
Domain	-	SPTBN5 TLN1 ASAP3 OBSCN DNM3 CIT PHLPP2 ANKS1A	5.54e-04	391	89	8	2.30.29.30
Domain	Dwarfin	SMAD2 SMAD3	6.17e-04	8	89	2	IPR013790
Domain	DWB	SMAD2 SMAD3	6.17e-04	8	89	2	SM00524
Domain	MH2	SMAD2 SMAD3	6.17e-04	8	89	2	PS51076
Domain	MH1	SMAD2 SMAD3	6.17e-04	8	89	2	PS51075
Domain	-	SMAD2 SMAD3	6.17e-04	8	89	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD2 SMAD3	6.17e-04	8	89	2	IPR013019
Domain	MH2	SMAD2 SMAD3	6.17e-04	8	89	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD2 SMAD3	6.17e-04	8	89	2	IPR001132
Domain	LRR_1	LRIG2 TRIL FBXL14 NRROS SKP2 PHLPP2	6.28e-04	219	89	6	PF00560
Domain	TPR-like_helical_dom	SPAG1 TTC16 P4HA3 TTC39A CABIN1 TTC3	8.67e-04	233	89	6	IPR011990
Domain	MAD_homology1_Dwarfin-type	SMAD2 SMAD3	1.44e-03	12	89	2	IPR003619
Domain	DWA	SMAD2 SMAD3	1.44e-03	12	89	2	SM00523
Domain	MH1	SMAD2 SMAD3	1.44e-03	12	89	2	PF03165
Domain	PLAC	ADAMTS10 ADAMTSL3	1.97e-03	14	89	2	PF08686
Domain	PH_DOMAIN	SPTBN5 ASAP3 OBSCN DNM3 CIT PHLPP2	2.17e-03	279	89	6	PS50003
Domain	SMAD_dom-like	SMAD2 SMAD3	2.58e-03	16	89	2	IPR017855
Domain	-	SMAD2 SMAD3	2.58e-03	16	89	2	2.60.200.10
Domain	PLAC	ADAMTS10 ADAMTSL3	3.64e-03	19	89	2	PS50900
Domain	Leu-rich_rpt_Cys-con_subtyp	FBXL14 SKP2	3.64e-03	19	89	2	IPR006553
Domain	PLAC	ADAMTS10 ADAMTSL3	3.64e-03	19	89	2	IPR010909
Domain	LRR_CC	FBXL14 SKP2	3.64e-03	19	89	2	SM00367
Pathway	WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES	WNT10B SREBF1 DICER1 SMAD2 SMAD3	6.69e-06	57	66	5	M39877
Pathway	PID_SMAD2_3PATHWAY	SMAD2 SMAD3 KPNB1	5.26e-05	16	66	3	M228
Pathway	WP_15Q25_COPY_NUMBER_VARIATION	DNM3 ADAMTSL3 RYR1 CPEB1	6.17e-05	46	66	4	M48105
Pubmed	Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3.	DICER1 SMAD2 SMAD3	7.63e-08	4	94	3	30280598
Pubmed	Identification of three novel Smad binding proteins involved in cell polarity.	DVL1 SMAD2 SMAD3	1.06e-06	8	94	3	12650946
Pubmed	Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.	THBS4 SMAD2 SMAD3	3.11e-06	11	94	3	38678560
Pubmed	Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification.	SMAD2 SMAD3	7.23e-06	2	94	2	26905010
Pubmed	Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells.	SMAD2 SMAD3	7.23e-06	2	94	2	21496353
Pubmed	Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition.	SMAD2 SMAD3	7.23e-06	2	94	2	36050359
Pubmed	Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development.	SMAD2 SMAD3	7.23e-06	2	94	2	11984875
Pubmed	Reduction of Smad2 caused by oxidative stress leads to necrotic death of hypertrophic chondrocytes associated with an endemic osteoarthritis.	SMAD2 SMAD3	7.23e-06	2	94	2	33769459
Pubmed	Polycomb determines responses to smad2/3 signaling in embryonic stem cell differentiation and in reprogramming.	SMAD2 SMAD3	7.23e-06	2	94	2	23666711
Pubmed	Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.	SMAD2 SMAD3	7.23e-06	2	94	2	15665291
Pubmed	Inhibiting Smad2/3 signaling in pluripotent mouse embryonic stem cells enhances endoderm formation by increasing transcriptional priming of lineage-specifying target genes.	SMAD2 SMAD3	7.23e-06	2	94	2	27012147
Pubmed	Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model.	SMAD2 SMAD3	7.23e-06	2	94	2	18210139
Pubmed	Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro.	SMAD2 SMAD3	7.23e-06	2	94	2	24925688
Pubmed	Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo.	SMAD2 SMAD3	7.23e-06	2	94	2	15520018
Pubmed	Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary.	SMAD2 SMAD3	7.23e-06	2	94	2	30111581
Pubmed	The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.	SMAD2 SMAD3	7.23e-06	2	94	2	17074756
Pubmed	Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis.	SMAD2 SMAD3	7.23e-06	2	94	2	20010874
Pubmed	Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation.	SMAD2 SMAD3	7.23e-06	2	94	2	16382155
Pubmed	miRNAs are required for generating a time delay critical for the circadian oscillator.	PER2 DICER1	7.23e-06	2	94	2	24094851
Pubmed	Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-β1-induced Smad and p38/ERK signaling.	SMAD2 SMAD3	7.23e-06	2	94	2	26919280
Pubmed	Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice.	SMAD2 SMAD3	7.23e-06	2	94	2	34710825
Pubmed	Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R.	SMAD2 SMAD3	7.23e-06	2	94	2	12700238
Pubmed	Asthma-derived fibroblast to myofibroblast transition is enhanced in comparison to fibroblasts derived from non-asthmatic patients in 3D in vitro culture due to Smad2/3 signalling.	SMAD2 SMAD3	7.23e-06	2	94	2	33245228
Pubmed	Formation of the definitive endoderm in mouse is a Smad2-dependent process.	SMAD2 SMAD3	7.23e-06	2	94	2	10862745
Pubmed	Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes.	SMAD2 SMAD3	7.23e-06	2	94	2	24086574
Pubmed	Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo.	SMAD2 SMAD3	7.23e-06	2	94	2	28666967
Pubmed	The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis.	SMAD2 SMAD3	7.23e-06	2	94	2	21229365
Pubmed	Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.	SMAD2 SMAD3	7.23e-06	2	94	2	22385658
Pubmed	Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.	SMAD2 SMAD3	7.23e-06	2	94	2	15630024
Pubmed	Specific Smad2/3 Linker Phosphorylation Indicates Esophageal Non-neoplastic and Neoplastic Stem-Like Cells and Neoplastic Development.	SMAD2 SMAD3	7.23e-06	2	94	2	32705438
Pubmed	Smad2/3 Linker Phosphorylation Is a Possible Marker of Pancreatic Stem/Progenitor Cells in the Regenerative Phase of Acute Pancreatitis.	SMAD2 SMAD3	7.23e-06	2	94	2	28099259
Pubmed	Arsenite Disrupts Zinc-Dependent TGFβ2-SMAD Activity During Murine Cardiac Progenitor Cell Differentiation.	SMAD2 SMAD3	7.23e-06	2	94	2	26354774
Pubmed	Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium.	SMAD2 SMAD3	7.23e-06	2	94	2	35780861
Pubmed	Implication of Smad2 and Smad3 in transforming growth factor-β-induced posterior capsular opacification of human lens epithelial cells.	SMAD2 SMAD3	7.23e-06	2	94	2	24911914
Pubmed	Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.	SMAD2 SMAD3	7.23e-06	2	94	2	29174331
Pubmed	Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations.	GREB1L GREB1	7.23e-06	2	94	2	29100090
Pubmed	Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.	SMAD2 SMAD3	7.23e-06	2	94	2	19172185
Pubmed	The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling.	SMAD2 SMAD3	7.23e-06	2	94	2	11937490
Pubmed	The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice.	SMAD2 SMAD3	7.23e-06	2	94	2	15133179
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	7.23e-06	2	94	2	37833372
Pubmed	Oocytes determine cumulus cell lineage in mouse ovarian follicles.	SMAD2 SMAD3	7.23e-06	2	94	2	17389684
Pubmed	SMAD2/3 Phosphorylation Is Downregulated in T Cells in HIV-Infected Patients.	SMAD2 SMAD3	7.23e-06	2	94	2	36226468
Pubmed	[Expression and significance of Smad2/3 and HPV16 E7 in cervical intraepithelial neoplasia and cervical carcinoma].	SMAD2 SMAD3	7.23e-06	2	94	2	17927854
Pubmed	Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors.	SMAD2 SMAD3	7.23e-06	2	94	2	29588413
Pubmed	Phosphorylation of Smad2/3 at specific linker threonine indicates slow-cycling intestinal stem-like cells before reentry to cell cycle.	SMAD2 SMAD3	7.23e-06	2	94	2	25185661
Pubmed	Neovibsanin B increases extracellular matrix proteins in optic nerve head cells via activation of Smad signalling pathway.	SMAD2 SMAD3	7.23e-06	2	94	2	26045877
Pubmed	Increased TGF-β1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling.	SMAD2 SMAD3	7.23e-06	2	94	2	22228025
Pubmed	Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion.	SMAD2 SMAD3	7.23e-06	2	94	2	17192514
Pubmed	Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis.	SMAD2 SMAD3	7.23e-06	2	94	2	34445177
Pubmed	Essential role of Smad3 in angiotensin II-induced vascular fibrosis.	SMAD2 SMAD3	7.23e-06	2	94	2	16556868
Pubmed	Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle.	SMAD2 SMAD3	7.23e-06	2	94	2	21883378
Pubmed	[The roles of Smad 2/3 in transforming growth factor-beta 1 signaling in human dental pulp cells].	SMAD2 SMAD3	7.23e-06	2	94	2	12760775
Pubmed	TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type.	SMAD2 SMAD3	7.23e-06	2	94	2	28557134
Pubmed	Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia.	SMAD2 SMAD3	7.23e-06	2	94	2	32733385
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	7.23e-06	2	94	2	8644734
Pubmed	Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.	SMAD2 SMAD3	7.23e-06	2	94	2	25908723
Pubmed	Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells.	SMAD2 SMAD3	7.23e-06	2	94	2	26992562
Pubmed	Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.	SMAD2 SMAD3	7.23e-06	2	94	2	15972691
Pubmed	Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.	SMAD2 SMAD3	7.23e-06	2	94	2	21732483
Pubmed	Smad2 and 3 transcription factors control muscle mass in adulthood.	SMAD2 SMAD3	7.23e-06	2	94	2	19357234
Pubmed	A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans.	GREB1L GREB1	7.23e-06	2	94	2	28739660
Pubmed	Expression pattern and phosphorylation status of Smad2/3 in different subtypes of human first trimester trophoblast.	SMAD2 SMAD3	7.23e-06	2	94	2	28864007
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	7.23e-06	2	94	2	29563550
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DSP AGL TLN1 OBSCN TTC3 RYR1 SMAD2 SMAD3 KPNB1	8.39e-06	497	94	9	23414517
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PER2 TLN1 FBXL14 DVL1 SREBF1 OBSCN CUL9 CABIN1 TTC3 DHX34 CIT RYR1 FAM83H	8.72e-06	1105	94	13	35748872
Pubmed	Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-β1 (TGF-β1) to Orchestrate Second Heart Field Development.	SMAD2 SMAD3 KPNB1	1.04e-05	16	94	3	26420484
Pubmed	Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration.	MELTF SMAD2 SMAD3	1.26e-05	17	94	3	38865240
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIL PER2 TLN1 FRMPD1 DNM3 CUL9 SNX19 WDR48	1.52e-05	407	94	8	12693553
Pubmed	Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway.	SMAD2 SMAD3	2.16e-05	3	94	2	29115383
Pubmed	Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells.	SMAD2 SMAD3	2.16e-05	3	94	2	30001393
Pubmed	cPLA2α activates PI3K/AKT and inhibits Smad2/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.	SMAD2 SMAD3	2.16e-05	3	94	2	28649002
Pubmed	Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-β/Smad2/3 pathway.	SMAD2 SMAD3	2.16e-05	3	94	2	24183998
Pubmed	Activation of the activin A-ALK-Smad pathway in systemic sclerosis.	SMAD2 SMAD3	2.16e-05	3	94	2	21377836
Pubmed	Inhibition of Smad signaling is implicated in cleft palate induced by all-trans retinoic acid.	SMAD2 SMAD3	2.16e-05	3	94	2	21555266
Pubmed	TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells.	SMAD2 SMAD3	2.16e-05	3	94	2	34463252
Pubmed	Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells.	SMAD2 SMAD3	2.16e-05	3	94	2	21646355
Pubmed	TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion.	SMAD2 SMAD3	2.16e-05	3	94	2	12815624
Pubmed	Itraconazole inhibits invasion and migration of pancreatic cancer cells by suppressing TGF-β/SMAD2/3 signaling.	SMAD2 SMAD3	2.16e-05	3	94	2	29484419
Pubmed	TGF-β1-induced epithelial-mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in human A549 lung cancer cells.	SMAD2 SMAD3	2.16e-05	3	94	2	23419524
Pubmed	Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma.	SMAD2 SMAD3	2.16e-05	3	94	2	12839562
Pubmed	PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.	SMAD2 SMAD3	2.16e-05	3	94	2	16751101
Pubmed	MicroRNA-146a regulates human foetal femur derived skeletal stem cell differentiation by down-regulating SMAD2 and SMAD3.	SMAD2 SMAD3	2.16e-05	3	94	2	24892945
Pubmed	Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway.	SMAD2 SMAD3	2.16e-05	3	94	2	25557170
Pubmed	Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling.	SMAD2 SMAD3	2.16e-05	3	94	2	31582430
Pubmed	A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.	SMAD2 SMAD3	2.16e-05	3	94	2	10197981
Pubmed	Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity.	SMAD2 SMAD3	2.16e-05	3	94	2	12191474
Pubmed	Pin1 promotes transforming growth factor-beta-induced migration and invasion.	SMAD2 SMAD3	2.16e-05	3	94	2	19920136
Pubmed	Response gene to complement 32 is essential for fibroblast activation in renal fibrosis.	SMAD2 SMAD3	2.16e-05	3	94	2	21990365
Pubmed	Genomewide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis.	SMAD2 SMAD3	2.16e-05	3	94	2	25431176
Pubmed	Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions.	SMAD2 SMAD3	2.16e-05	3	94	2	32323728
Pubmed	Using RNA interference to identify the different roles of SMAD2 and SMAD3 in NIH/3T3 fibroblast cells.	SMAD2 SMAD3	2.16e-05	3	94	2	18506886
Pubmed	Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit.	SMAD2 SMAD3	2.16e-05	3	94	2	12023901
Pubmed	Lefty inhibits glioma growth by suppressing Nodal-activated Smad and ERK1/2 pathways.	SMAD2 SMAD3	2.16e-05	3	94	2	25304053
Pubmed	Burn-induced thymic apoptosis corresponds with altered TGF-beta(1) and Smad 2/3.	SMAD2 SMAD3	2.16e-05	3	94	2	12069494
Pubmed	Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling.	SMAD2 SMAD3	2.16e-05	3	94	2	17035229
Pubmed	Increased Smad2/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic valve stenosis: Evidence of systemic activation of platelet-derived TGF-β1 and correlation with cardiac dysfunction.	SMAD2 SMAD3	2.16e-05	3	94	2	27067480
Pubmed	Progesterone-dependent release of transforming growth factor-beta1 from epithelial cells enhances the endometrial decidualization by turning on the Smad signalling in stromal cells.	SMAD2 SMAD3	2.16e-05	3	94	2	16403803
Pubmed	Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta/Smad signaling in smooth muscle cells of fibrofatty lesions.	SMAD2 SMAD3	2.16e-05	3	94	2	15166010
Pubmed	The SMAD2/3 pathway is involved in hepaCAM-induced apoptosis by inhibiting the nuclear translocation of SMAD2/3 in bladder cancer cells.	SMAD2 SMAD3	2.16e-05	3	94	2	26873485
Pubmed	Asiaticoside hinders the invasive growth of keloid fibroblasts through inhibition of the GDF-9/MAPK/Smad pathway.	SMAD2 SMAD3	2.16e-05	3	94	2	28346732
Interaction	BRCA1 interactions	ZZZ3 ATRIP DSP HSPA4L OGFR AGL TLN1 OBSCN PSMC6 SLFN11 MCM10 CABIN1 SKP2 CIT SMAD2 SMAD3 FAM83H KPNB1 WDR48	2.95e-06	1249	92	19	int:BRCA1
GeneFamily	NLR family	NOD1 NLRC4 NLRP13	7.97e-05	25	61	3	666
GeneFamily	Schlafen family	SLFN13 SLFN11	2.33e-04	7	61	2	1110
GeneFamily	SMAD family	SMAD2 SMAD3	3.09e-04	8	61	2	750
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SPAG1 TTC16 TTC39A TTC3	6.13e-04	115	61	4	769
GeneFamily	F-box and leucine rich repeat proteins	FBXL14 SKP2	2.26e-03	21	61	2	558
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	NOD1 NLRC4	4.58e-03	30	61	2	959
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCTD9 THBS4 NLRC4 SMAD3 PHLPP2 BID	1.49e-06	167	94	6	f5bffa77061baec0ba87bd688a047595f32534db
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	CCDC14 SPAG1 HSPA4L TTC39A SLFN11 WDR62	2.69e-06	185	94	6	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	ADAMTS10 AOX1 GREB1 ADAMTSL3 ADGRG4 CPEB1	3.33e-06	192	94	6	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	Transverse-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	CCDC14 NOD1 ABCB10 MCM10 SMC2 CIT	4.09e-06	199	94	6	170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCell	VE-CD8-naive_CD4\|VE / Condition, Cell_class and T cell subcluster	SPTBN5 NOD1 SLC16A4 DNM3 P4HA3	2.27e-05	160	94	5	255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN5 OR2AT4 SLFN13 MCM10 WDR62	2.79e-05	167	94	5	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	KCTD9 GPR150 SMC2 CIT WDR62	3.04e-05	170	94	5	73601c873b177d5d134618d8e228c51381119f7d
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC14 TTC39A MCM10 WDR62 WDR48	3.89e-05	179	94	5	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MELTF DNM3 SCTR ADAMTSL3 SIAH3	5.16e-05	190	94	5	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	AOX1 GREB1 ADAMTSL3 ADGRG4 CPEB1	5.16e-05	190	94	5	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MELTF DNM3 SCTR ADAMTSL3 SIAH3	5.16e-05	190	94	5	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	GREB1L DSP ASPSCR1 GREB1 ABCC2	5.56e-05	193	94	5	503a979328c68b096680b71359a26f02fafdff35
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CCDC14 MELTF SLFN11 SMC2 WDR62	5.69e-05	194	94	5	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	control-Myeloid-Immature_Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	THBS4 HSPA4L SLFN13 SMC2 CIT	5.83e-05	195	94	5	bfaceb0601cf3855f38d6e1f482f01ad03ef11fe
ToppCell	mild-Myeloid-Immature_Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	THBS4 HSPA4L SLFN13 SMC2 CIT	6.12e-05	197	94	5	bd9d57e0c873f6526dca322f4dad8e6bd692586c
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLFN13 MCM10 SMC2 CIT WDR62	6.27e-05	198	94	5	281fc2536cdc4c717b30de156e563c0e4baba99d
ToppCell	MNPs-Dividing_Macrophages\|MNPs / lung cells shred on cell class, cell subclass, sample id	SLFN13 MCM10 SMC2 CIT WDR62	6.42e-05	199	94	5	5952980d0ece5d73f3e9f340c56a38b34d2f2309
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|Control_saline / Treatment groups by lineage, cell group, cell type	NARF TLN1 DNM3 ARMC2 BID	6.42e-05	199	94	5	86d4e5dd3bcc6bafa48fd0211dad39a2456b53be
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	ASPSCR1 GREB1 MCM10 SMC2 SKP2	6.58e-05	200	94	5	691b3edf7d8449556e8bf611662eb85772959f0f
ToppCell	mLN-T_cell-cycling_gd_T\|mLN / Region, Cell class and subclass	SLFN13 MCM10 SMC2 CIT WDR62	6.58e-05	200	94	5	4efeef51f885ee8f6dd3911a536cc49e3c14da98
ToppCell	Transverse-(2)_B_cell-(24)_B_cell_cycling\|Transverse / shred on region, Cell_type, and subtype	CCDC14 ABCB10 MCM10 SMC2 CIT	6.58e-05	200	94	5	e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCell	Transverse-B_cell-B_cell_cycling\|Transverse / Region, Cell class and subclass	CCDC14 ABCB10 MCM10 SMC2 CIT	6.58e-05	200	94	5	0e270f8019d9f22068ca426d661937262a5cd331
ToppCell	mLN-(1)_T_cell-(18)_cycling_gd_T\|mLN / shred on region, Cell_type, and subtype	SLFN13 MCM10 SMC2 CIT WDR62	6.58e-05	200	94	5	e8a0a88a8344e80783931115bbe6cd5b62a4c1f7
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	ASPSCR1 GREB1 MCM10 SMC2 SKP2	6.58e-05	200	94	5	36a110aa91a791fdf1142e7869e8aa0d342402d0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	ASPSCR1 GREB1 MCM10 SMC2 SKP2	6.58e-05	200	94	5	4e077aa7faddcebdfc54667f8b3990704441005b
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLFN13 MCM10 SMC2 CIT WDR62	6.58e-05	200	94	5	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	ASPSCR1 GREB1 MCM10 SMC2 SKP2	6.58e-05	200	94	5	d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCell	(3)_MNP-(3)_DC_Monocyte_Dividing\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	SLFN13 MCM10 SMC2 CIT WDR62	6.58e-05	200	94	5	d94fe9bd6ee7c1fed14666f24de41bda014e299b
ToppCell	mild-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SLFN13 MCM10 SMC2 CIT WDR62	6.58e-05	200	94	5	63cc57b9331459efbb73051d174d198a3568b938
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	THBS4 SCTR P4HA3 GREB1	7.00e-05	104	94	4	bf27bc52f440d1e94108b35ad85ed593201164c9
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE-Gja1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	THBS4 SCTR P4HA3 GREB1	7.00e-05	104	94	4	10e6c5b63c28d8c47e89ab130a7daf01700dd4e4
Drug	PHA-00745360 [351320-33-7]; Up 200; 1uM; PC3; HT_HG-U133A	GREB1L PER2 ASAP3 RDH5 ASPSCR1 ABCC2 DHX34 PHLPP2	1.30e-06	198	91	8	4562_UP
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	OGFR GREB1 CABIN1 DHX34 WDR62 SMAD3 WDR48	1.29e-05	194	91	7	3316_DN
Drug	Neomycin sulfate [1405-10-3]; Down 200; 4.2uM; MCF7; HT_HG-U133A	LRIG2 TLN1 GREB1 CABIN1 DHX34 SMAD3 WDR48	1.29e-05	194	91	7	7221_DN
Drug	Ketorolac tromethamine [74103-07-4]; Up 200; 10.6uM; PC3; HT_HG-U133A	NOD1 WNT10B ASPSCR1 CABIN1 SKP2 WDR62 CPEB1	1.43e-05	197	91	7	7286_UP
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	9.35e-05	5	91	2	DOID:11198 (is_implicated_in)
Disease	Loeys-Dietz Syndrome	SMAD2 SMAD3	1.96e-04	7	91	2	C2697932
Disease	Colorectal Carcinoma	ZZZ3 ABCB10 ASAP3 OBSCN ABCC2 SLC44A4 ADAMTSL3 SMAD2 SMAD3	3.20e-04	702	91	9	C0009402
Disease	pre-malignant neoplasm (implicated_via_orthology)	SMAD3 BID	3.34e-04	9	91	2	DOID:0060071 (implicated_via_orthology)
Disease	BMI-adjusted waist-hip ratio, adult onset asthma	ADAMTSL3 SMAD3	3.34e-04	9	91	2	EFO_0007788, EFO_1002011
Disease	Familial thoracic aortic aneurysm and aortic dissection	ADAMTS10 SMAD2 SMAD3	5.95e-04	53	91	3	C4707243
Disease	inferior parietal cortex volume measurement	TBC1D15 GREB1	1.55e-03	19	91	2	EFO_0010307
Disease	Left Ventricle Remodeling	SMAD2 SMAD3	1.90e-03	21	91	2	C0600520
Disease	Ventricular Remodeling	SMAD2 SMAD3	1.90e-03	21	91	2	C0600519
Disease	mortality	DHX34 DICER1 NLRC4 TRAV20	2.05e-03	173	91	4	EFO_0004352
Disease	Primary microcephaly	CIT WDR62	2.09e-03	22	91	2	C0431350
Disease	Autosomal Recessive Primary Microcephaly	CIT WDR62	2.09e-03	22	91	2	C3711387
Disease	Lynch syndrome (is_implicated_in)	SMAD2 SMAD3	2.48e-03	24	91	2	DOID:3883 (is_implicated_in)
Disease	Uterine leiomyoma	DNM3 GREB1 ARMC2	2.83e-03	91	91	3	HP_0000131
Disease	birth weight, parental genotype effect measurement	ASPSCR1 ARMC2 SMAD3 NLRP13	2.99e-03	192	91	4	EFO_0004344, EFO_0005939
Disease	forced expiratory volume	AGL DNM3 ASPSCR1 SLC44A4 ADAMTSL3 ARMC2 SMAD3 ANKS1A	3.05e-03	789	91	8	EFO_0004314

Protein segments in the cluster

Peptide	Gene	Start	Entry
CNRDLLSVLEAFANG	ASAP3	556	Q8TDY4
LQLDDGSRLQDSFCS	ASPSCR1	96	Q9BZE9
LRLDNSSDGSSRCQI	ADGRG4	3006	Q8IZF6
SSCFGNEDTNTLLLL	ARMC2	796	Q8NEN0
DYSDNLTRLCLGLSA	ABCB10	206	Q9NRK6
LSTCSGLRGILQFEN	ADAM32	111	Q8TC27
SQNDSCTGRSADLLL	ANKS1A	861	Q92625
LTLSNASDGFNLERL	DICER1	1301	Q9UPY3
GAVDCNLELFSLQSL	CCDC14	516	Q49A88
SSDFLDLIQSLLCGQ	CIT	331	O14578
ITSFLDSGLGLCLNN	ADAMTS10	441	Q9H324
TLDQLTDALGGNLCR	AOX1	136	Q06278
DLCDLFINLLNESSL	NWD2	491	Q9ULI1
GNVSCALSLSREFLL	P4HA3	241	Q7Z4N8
CLNLLSNRLGTSQFF	MTX3	176	Q5HYI7
SELRCQGLNFSGADL	KCTD9	216	Q7L273
LGLSSTQSDTLFLDC	KIAA0100	511	Q14667
SGISDNFRCLLSLTS	MCMDC2	281	Q4G0Z9
SRAQGGLFETLCDQL	NLRC4	206	Q9NPP4
SLNISCSDLLFSGLL	GREB1	1861	Q4ZG55
LQDAFSALGQSCLLE	DNM3	16	Q9UQ16
LLNLLLNEDLCSASG	PER2	1056	O15055
SALDCLAALGQVFRN	PNMA6E	386	A0A0J9YXQ4
LSCTDNRINSILGLF	OR51F2	201	Q8NH61
QDLLRLACSDIRFNS	OR51V1	191	Q9H2C8
TLQCRSRLGFNEFSL	KIR3DL3	46	Q8N743
NESLGSLNSLACLLD	NOD1	171	Q9Y239
SSLTNCLFRILEAAG	ABCC2	1341	Q92887
NDLRDLTQCVSLFLF	MCM10	321	Q7L590
LGLGDSCFNTQLLSI	MFSD11	361	O43934
RSLNLRSCDNISDTG	FBXL14	256	Q8N1E6
ADFNLRTNSSGLLIC	GREB1L	1716	Q9C091
SSDILALLNDGSLFC	MSL2	126	Q9HCI7
LSEGQDASFQCRLSR	OBSCN	4261	Q5VST9
GDLLQLSFASSQRDL	CABIN1	591	Q9Y6J0
LNCFRRALEIDSSNL	CABIN1	1126	Q9Y6J0
ETSGFLCLLDLAQRA	FRMPD1	651	Q5SYB0
DGYLNSLCTVRALLQ	DSP	761	P15924
NNGSSLRDECITNLL	BID	6	P55957
TSDRIQFNDLQSLLC	KPNB1	571	Q14974
LSSRFEGSTLNDLLN	CUL9	551	Q8IWT3
EGCSSAARNGLLLLN	CUL9	861	Q8IWT3
LFLCFLEDLERNNGS	SLC44A4	666	Q53GD3
DANDLCLGLQSLSLT	CPEB1	91	Q9BZB8
VFGDLCSNLATLNLN	DVL1	496	O14640
LAFTGLNLVARNECS	ATRIP	381	Q8WXE1
VFGDLCSNLATLNLN	DVL1P1	471	P54792
LESCLLDLRDSFAQQ	FAM83H	786	Q6ZRV2
LFSRSLDTNGDCSRL	DHX34	906	Q14147
ASLIRGNRSNCALFS	RYR1	526	P21817
FRSLLSDQLGCEVLN	SLFN13	561	Q68D06
GNLRDLDLSGNCLTT	NRROS	536	Q86YC3
LLGDRFLSFSSCLLQ	OR2AT4	91	A6NND4
ALNLEGCALSQGSLR	OGFR	411	Q9NZT2
NTFLLRFNDLDLCVS	TMEM248	56	Q9NWD8
QALLSQDFELLCRDG	MELTF	246	P08582
ATGDLACRFLQLLQA	GPR150	116	Q8NGU9
NSSVQDDLRRLCSGF	PTCHD4	531	Q6ZW05
DGDCLVLNTSLAQLF	SIAH3	231	Q8IW03
FRSLLSDQLGCEVLN	SLFN11	561	Q7Z7L1
CDSGFGRLLALQLDQ	RDH5	36	Q92781
CRGNLQGSSLSLFLD	SPTBN5	3561	Q9NRC6
ALGYLQLLNSCSDAA	SREBF1	836	P36956
IAGLTNRNLFCISEF	C10orf120	276	Q5SQS8
SRLSSQCLGQSFLLR	PRY	111	O14603
NLVRLNLSGCSGFSE	SKP2	231	Q13309
RGSLFQVASLQDCFL	THBS4	191	P35443
ALRLQEGESSSLNCS	TRAV20	31	A0A0B4J274
SAQCLFDLLQSLEGE	UNC80	2296	Q8N2C7
LLLNRDGTQCLSGSS	WDR48	216	Q8TAF3
DLCRNSTVNRFLGLA	SLC16A4	416	O15374
NLQTLCLDGNFLTTL	PHLPP2	346	Q6ZVD8
SSLCRQLGQDLLNSY	HSPA4L	586	O95757
SNSERFCLGLLSNVN	SMAD2	306	Q15796
SERFCLGLLSNVNRN	SMAD3	266	P84022
AALNSCLRDLDQASL	TLN1	1666	Q9Y490
LTSRNGSLFRNCTQD	SCTR	96	P47872
DCGLQLANDSVNRLS	SPAG1	551	Q07617
SLRNNALSALSGDIF	TRIL	331	Q7L0X0
SSLANLGELCQRLDF	TANGO6	976	Q9C0B7
CRSAAQAFTELLNGL	TTC3	506	P53804
QLSTLLRLLDSGFCS	TBC1D15	501	Q8TC07
GSFLSDRIQDALCAL	SNX19	391	Q92543
CFLLGISNLSQVRAS	SMC2	46	O95347
NLRLTLSSACDGLLQ	WDR62	1291	O43379
TLLARAVASQLDCNF	PSMC6	181	P62333
LQLCDFSSAAQNLRR	TTC16	106	Q8NEE8
GLLFLALCSRALSNE	WNT10B	16	O00744
ILNSDLANLGAECLR	RPE	11	Q96AT9
CLLQRAALTFLQGSS	TTC39A	131	Q5SRH9
LNGLDESFCGRTLRN	ZZZ3	16	Q8IYH5
CRQLLTDGSFLNLSD	ADAMTSL3	786	P82987
LGLSRSCYSLANQLE	AGL	166	P35573
TLEAGCFDNLSSSLL	LRIG2	181	O94898
NLSAASCQDLALFLT	NLRP13	821	Q86W25
LQSLNLSGCSFTREG	NLRP13	926	Q86W25
NLSVTDASRRLCGFL	NARF	111	Q9UHQ1
ASIFQLQDADRSCLL	EXD3	126	Q8N9H8