Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	RGPD2 LRRK2 SRGAP2 TBC1D8 TBC1D16 ASAP2 SRGAP1 RIN2 USP6NL	1.03e-05	279	99	9	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RGPD2 RALGDS LRRK2 ARHGEF18 SRGAP2 TBC1D8 TBC1D16 ASAP2 SRGAP1 RIN2 USP6NL	4.27e-05	507	99	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RGPD2 RALGDS LRRK2 ARHGEF18 SRGAP2 TBC1D8 TBC1D16 ASAP2 SRGAP1 RIN2 USP6NL	4.27e-05	507	99	11	GO:0030695
GeneOntologyMolecularFunction	helicase activity	MCM8 TDRD9 CHD3 CHD4 CHD6 DNA2	1.36e-04	158	99	6	GO:0004386
GeneOntologyMolecularFunction	small GTPase binding	RGPD2 GGA2 LRRK2 SRGAP2 ASB14 SRGAP1 RIN2 USP6NL	1.97e-04	321	99	8	GO:0031267
GeneOntologyMolecularFunction	ATP-dependent activity	HYOU1 MCM8 TDRD9 CHD3 CHD4 KIF20A DYNC1LI1 CHD6 TOR3A DNA2 HSPA4	2.31e-04	614	99	11	GO:0140657
GeneOntologyMolecularFunction	enzyme activator activity	RGPD2 LRRK2 SAV1 SRGAP2 TBC1D8 TBC1D16 ASAP2 NOD1 SRGAP1 RIN2 USP6NL	4.05e-04	656	99	11	GO:0008047
GeneOntologyMolecularFunction	GTPase binding	RGPD2 GGA2 LRRK2 SRGAP2 ASB14 SRGAP1 RIN2 USP6NL	4.25e-04	360	99	8	GO:0051020
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	MCM8 CHD3 CHD4 CHD6 DNA2	4.27e-04	127	99	5	GO:0008094
GeneOntologyMolecularFunction	MutSalpha complex binding	ATR MCM8	5.03e-04	7	99	2	GO:0032407
GeneOntologyMolecularFunction	enzyme regulator activity	PRPSAP1 RGPD2 RALGDS LRRK2 SAV1 ARHGEF18 SRGAP2 BIRC6 ITIH3 TBC1D8 TBC1D16 CCNH ASAP2 NOD1 SRGAP1 RIN2 USP6NL	5.69e-04	1418	99	17	GO:0030234
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD3 CHD4 CHD6	8.13e-04	37	99	3	GO:0140658
GeneOntologyMolecularFunction	mismatch repair complex binding	ATR MCM8	1.30e-03	11	99	2	GO:0032404
GeneOntologyMolecularFunction	ATP hydrolysis activity	MCM8 TDRD9 CHD3 CHD4 KIF20A CHD6 TOR3A DNA2	1.58e-03	441	99	8	GO:0016887
GeneOntologyBiologicalProcess	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	SRGAP2 SRGAP2C	2.23e-05	2	98	2	GO:0021816
Domain	srGAP2	SRGAP2 SRGAP2C SRGAP2B	1.40e-07	3	98	3	IPR030252
Domain	FCH	SRGAP2 SRGAP2C SRGAP1 SRGAP2B	4.85e-06	22	98	4	PF00611
Domain	FCH	SRGAP2 SRGAP2C SRGAP1 SRGAP2B	4.85e-06	22	98	4	SM00055
Domain	FCH_dom	SRGAP2 SRGAP2C SRGAP1 SRGAP2B	5.85e-06	23	98	4	IPR001060
Domain	F_BAR	SRGAP2 SRGAP2C SRGAP1 SRGAP2B	8.28e-06	25	98	4	IPR031160
Domain	F_BAR	SRGAP2 SRGAP2C SRGAP1 SRGAP2B	8.28e-06	25	98	4	PS51741
Domain	CHD_N	CHD3 CHD4	8.15e-05	3	98	2	IPR012958
Domain	CHD_C2	CHD3 CHD4	8.15e-05	3	98	2	IPR012957
Domain	CHDCT2	CHD3 CHD4	8.15e-05	3	98	2	PF08074
Domain	CHDNT	CHD3 CHD4	8.15e-05	3	98	2	PF08073
Domain	DUF1086	CHD3 CHD4	8.15e-05	3	98	2	IPR009462
Domain	DUF1087	CHD3 CHD4	8.15e-05	3	98	2	IPR009463
Domain	DUF1087	CHD3 CHD4	8.15e-05	3	98	2	PF06465
Domain	DUF1086	CHD3 CHD4	8.15e-05	3	98	2	PF06461
Domain	DUF1087	CHD3 CHD4	8.15e-05	3	98	2	SM01147
Domain	DUF1086	CHD3 CHD4	8.15e-05	3	98	2	SM01146
Domain	Chromo_domain	CHD3 CHD4 CHD6	2.62e-04	24	98	3	IPR023780
Domain	Chromo	CHD3 CHD4 CHD6	3.34e-04	26	98	3	PF00385
Domain	FAT	ATR TRRAP	4.03e-04	6	98	2	PS51189
Domain	FATC	ATR TRRAP	4.03e-04	6	98	2	PS51190
Domain	FAT	ATR TRRAP	4.03e-04	6	98	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR TRRAP	4.03e-04	6	98	2	IPR003151
Domain	FATC_dom	ATR TRRAP	4.03e-04	6	98	2	IPR003152
Domain	PIK_FAT	ATR TRRAP	4.03e-04	6	98	2	IPR014009
Domain	FATC	ATR TRRAP	4.03e-04	6	98	2	SM01343
Domain	CHROMO_1	CHD3 CHD4 CHD6	4.17e-04	28	98	3	PS00598
Domain	CHROMO_2	CHD3 CHD4 CHD6	4.17e-04	28	98	3	PS50013
Domain	ZnF_UBR1	UBR1 UBR3	5.63e-04	7	98	2	SM00396
Domain	ZF_UBR	UBR1 UBR3	5.63e-04	7	98	2	PS51157
Domain	zf-UBR	UBR1 UBR3	5.63e-04	7	98	2	PF02207
Domain	Znf_UBR	UBR1 UBR3	5.63e-04	7	98	2	IPR003126
Domain	SNF2_N	CHD3 CHD4 CHD6	6.22e-04	32	98	3	IPR000330
Domain	SNF2_N	CHD3 CHD4 CHD6	6.22e-04	32	98	3	PF00176
Domain	Chromodomain-like	CHD3 CHD4 CHD6	6.22e-04	32	98	3	IPR016197
Domain	Chromo/shadow_dom	CHD3 CHD4 CHD6	6.82e-04	33	98	3	IPR000953
Domain	CHROMO	CHD3 CHD4 CHD6	6.82e-04	33	98	3	SM00298
Domain	-	TANC2 RGPD2 ATR WFS1 TRRAP TANC1	7.78e-04	207	98	6	1.25.40.10
Domain	DNA/RNA_helicase_DEAH_CS	CHD3 CHD4 CHD6	8.12e-04	35	98	3	IPR002464
Domain	DEAH_ATP_HELICASE	CHD3 CHD4 CHD6	1.03e-03	38	98	3	PS00690
Domain	TPR-like_helical_dom	TANC2 RGPD2 ATR WFS1 TRRAP TANC1	1.43e-03	233	98	6	IPR011990
Domain	P-loop_NTPase	TANC2 MCM8 TDRD9 LRRK2 CHD3 CHD4 KIF20A NOD1 DYNC1LI1 CHD6 TOR3A DNA2	1.59e-03	848	98	12	IPR027417
Domain	-	HYOU1 HSPA4	1.74e-03	12	98	2	2.60.34.10
Domain	HSP70_peptide-bd	HYOU1 HSPA4	1.74e-03	12	98	2	IPR029047
Domain	-	HYOU1 HSPA4	2.05e-03	13	98	2	1.20.1270.10
Domain	Heat_shock_70_CS	HYOU1 HSPA4	2.05e-03	13	98	2	IPR018181
Domain	HSP70_C	HYOU1 HSPA4	2.05e-03	13	98	2	IPR029048
Domain	Recoverin	KCNIP2 KCNIP4	2.05e-03	13	98	2	IPR028846
Domain	ARM-type_fold	USP34 ATR LRRK2 USP24 HUWE1 TRRAP UPF2	2.06e-03	339	98	7	IPR016024
Domain	TBC	TBC1D8 TBC1D16 USP6NL	2.17e-03	49	98	3	SM00164
Domain	Helicase_C	TDRD9 CHD3 CHD4 CHD6	2.43e-03	107	98	4	PF00271
Domain	HELICc	TDRD9 CHD3 CHD4 CHD6	2.43e-03	107	98	4	SM00490
Domain	Helicase_C	TDRD9 CHD3 CHD4 CHD6	2.52e-03	108	98	4	IPR001650
Domain	HELICASE_CTER	TDRD9 CHD3 CHD4 CHD6	2.60e-03	109	98	4	PS51194
Domain	HELICASE_ATP_BIND_1	TDRD9 CHD3 CHD4 CHD6	2.60e-03	109	98	4	PS51192
Domain	DEXDc	TDRD9 CHD3 CHD4 CHD6	2.60e-03	109	98	4	SM00487
Domain	Helicase_ATP-bd	TDRD9 CHD3 CHD4 CHD6	2.69e-03	110	98	4	IPR014001
Domain	RabGAP-TBC	TBC1D8 TBC1D16 USP6NL	2.71e-03	53	98	3	PF00566
Domain	Rab-GTPase-TBC_dom	TBC1D8 TBC1D16 USP6NL	3.02e-03	55	98	3	IPR000195
Domain	TBC_RABGAP	TBC1D8 TBC1D16 USP6NL	3.02e-03	55	98	3	PS50086
Domain	-	ATR TRRAP	3.12e-03	16	98	2	1.10.1070.11
Domain	PI3Kc	ATR TRRAP	3.12e-03	16	98	2	SM00146
Domain	HSP70	HYOU1 HSPA4	3.12e-03	16	98	2	PF00012
Domain	HSP70_2	HYOU1 HSPA4	3.52e-03	17	98	2	PS00329
Domain	HSP70_1	HYOU1 HSPA4	3.52e-03	17	98	2	PS00297
Domain	HSP70_3	HYOU1 HSPA4	3.52e-03	17	98	2	PS01036
Domain	PI3_PI4_kinase	ATR TRRAP	3.95e-03	18	98	2	PF00454
Domain	PI3_4_KINASE_1	ATR TRRAP	3.95e-03	18	98	2	PS00915
Domain	PI3_4_KINASE_2	ATR TRRAP	3.95e-03	18	98	2	PS00916
Domain	PI3/4_kinase_cat_dom	ATR TRRAP	3.95e-03	18	98	2	IPR000403
Domain	PI3_4_KINASE_3	ATR TRRAP	3.95e-03	18	98	2	PS50290
Domain	Hsp_70_fam	HYOU1 HSPA4	3.95e-03	18	98	2	IPR013126
Domain	-	EZR RGPD2 APBB2 ARHGEF18 PLEKHH1 ASAP2 CADPS2	4.52e-03	391	98	7	2.30.29.30
Domain	UBA-like	USP24 HUWE1 TOLLIP	4.63e-03	64	98	3	IPR009060
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EZR USP34 DSP ADAM23 SYNE1 APBB2 CHD4 SRGAP2 HUWE1 PRPF8 PNISR PLEKHH1 GMCL1 S100B MICAL2 MRPS9 TOLLIP CHD6 CADPS2 EXOC4	6.25e-10	1285	100	20	35914814
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 DSP GARS1 PTPN23 CHD4 HUWE1 PRPF8 TRRAP BIRC6 NGDN KIF20A UPF2 MICAL2 SHCBP1 DYNC1LI1 TANC1 CDC5L HSPA4 CPSF3 EXOC4	1.52e-09	1353	100	20	29467282
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2 SRGAP2C SRGAP2B	2.31e-08	3	100	3	22559944
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EZR RGPD2 KRT13 HYOU1 DSP SYNE1 GARS1 DGKA CHD3 CHD4 PRPF8 PNISR NGDN CCNH CFAP45 MRPS9 CHD6 CADPS2 SPAG17	2.61e-08	1442	100	19	35575683
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 RGPD2 TRIML2 DSP USP24 CHD3 CHD4 HUWE1 BIRC6 CHD6 EXOC4	3.60e-08	418	100	11	34709266
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2 SRGAP2C SRGAP2B	9.21e-08	4	100	3	22559943
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PRPSAP1 EZR KRT9 KRT13 HYOU1 DSP GARS1 USP24 PTPN23 CHD4 SRGAP2 HUWE1 PRPF8 BIRC6 DNAJC17 MRPS9 CDC5L HSPA4	1.08e-07	1415	100	18	28515276
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TANC2 ATR DSP USP24 CHD3 CHD4 HUWE1 PRPF8 DYNC1LI1 CDC5L CPSF3 EXOC4	1.19e-07	582	100	12	20467437
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UBR1 ATR DSP USP24 CHD3 CHD4 HUWE1 PNISR TRRAP CACTIN SHCBP1 DYNC1LI1 PLA2G4A	3.57e-07	774	100	13	15302935
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 RALGDS HYOU1 ATR MCM8 DGKA CHD3 UPF2 SHCBP1 TANC1 DNA2 EXOC4	3.86e-07	650	100	12	38777146
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	EZR KRT9 DSP SYNE1 CHD4 PRPF8 PNISR TRRAP CCDC61 UPF2 CFAP45 DYNC1LI1 CHD6 CDC5L CPSF3	4.82e-07	1082	100	15	38697112
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PRPSAP1 EZR HYOU1 DSP SRGAP2 PRPF8 KCNIP2 TRRAP CCNH CACTIN ASAP2 SHCBP1 MRPS9 KCNIP4 CDC5L EXOC4	7.89e-07	1284	100	16	17353931
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	USP34 HYOU1 SAV1 ARHGEF18 SRGAP2 HUWE1 BIRC6 DYNC1LI1 CHD6 TANC1 CDC5L CPSF3	1.36e-06	733	100	12	34672954
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	KRT13 MCM8 WFS1 APBB2 RFX6 FPGT ZNF446 GMCL1 S100B NOD1 TP63 KCNIP4	1.54e-06	742	100	12	26871637
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	HYOU1 USP24 PTPN23 CHD4 HUWE1 PRPF8 DYNC1LI1 CDC5L HSPA4 CPSF3 EXOC4	2.35e-06	638	100	11	33239621
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	USP34 ATR HUWE1	2.73e-06	10	100	3	17478428
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 HYOU1 DSP USP24 CHD4 HUWE1 PRPF8 TRRAP BIRC6 HSPA4 CPSF3	2.94e-06	653	100	11	22586326
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TANC2 HYOU1 DSP WFS1 SYNE1 CHD3 SRGAP2 UPF2 MICAL2 SCAPER MRPS9 TOLLIP TANC1 CDC5L HSPA4 EXOC4	3.20e-06	1431	100	16	37142655
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	KRT9 KRT13 DSP HUWE1 PRPF8	4.58e-06	84	100	5	29563501
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	KRT13 HYOU1 WFS1 SYNE1 PRPF8 CCDC61 TBC1D8 CACTIN DNAJC17 MRPS9 TANC1 CDC5L DNA2 HSPA4 USP6NL EXOC4	5.21e-06	1487	100	16	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MCM8 APBB2 ARHGEF18 CHD3 SRGAP2 HUWE1 KCNIP2 TRRAP PLEKHH1 ASAP2 MICAL2 RIN2 CHD6 TANC1 ERMARD EXOC4	5.30e-06	1489	100	16	28611215
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	KRT9 HYOU1 GARS1 USP24 CHD4 HUWE1 PRPF8 NGDN CACTIN UPF2 MRPS9 CHD6 CDC5L HSPA4 CPSF3	5.45e-06	1318	100	15	30463901
Pubmed	LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.	LRRK2 EXOC4	8.18e-06	2	100	2	33498474
Pubmed	CHD chromatin remodelling enzymes and the DNA damage response.	CHD4 CHD6	8.18e-06	2	100	2	23954449
Pubmed	Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.	CHD3 CHD4	8.18e-06	2	100	2	7560064
Pubmed	Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.	SRGAP2 SRGAP1	8.18e-06	2	100	2	33984363
Pubmed	Effects of metal-binding properties of human Kv channel-interacting proteins on their molecular structure and binding with Kv4.2 channel.	KCNIP2 KCNIP4	8.18e-06	2	100	2	16951992
Pubmed	The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development.	SRGAP2C SRGAP2B	8.18e-06	2	100	2	31822692
Pubmed	SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.	SRGAP2 SRGAP2C	8.18e-06	2	100	2	27373832
Pubmed	CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis.	CHD3 CHD6	8.18e-06	2	100	2	17027977
Pubmed	The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.	CHD3 CHD4	8.18e-06	2	100	2	7575689
Pubmed	Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.	TANC2 TANC1	8.18e-06	2	100	2	21068316
Pubmed	Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.	CHD3 CHD4	8.18e-06	2	100	2	35568926
Pubmed	Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.	CHD3 CHD4	8.18e-06	2	100	2	8843877
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CHD3 HUWE1 TRRAP BIRC6 KIF20A CACTIN CHD6 CDC5L DNA2	8.78e-06	469	100	9	27634302
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	TANC2 EZR DSP USP24 ITIH3 DYNC1LI1 CHD6 CDC5L HSPA4	9.72e-06	475	100	9	31040226
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	HYOU1 DSP PTPN23 HUWE1 BIRC6 CCDC61 CCNH CACTIN DUSP29 UBR3 TANC1 CDC5L CPSF3	9.99e-06	1049	100	13	27880917
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	EZR HYOU1 ATR DSP GARS1 CHD4 HUWE1 PRPF8 HSPA4	1.01e-05	477	100	9	31300519
Pubmed	A human MAP kinase interactome.	RALGDS KRT13 DSP SYNE1 PTPN23 PNISR ASAP2 TOLLIP CHD6	1.17e-05	486	100	9	20936779
Pubmed	p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.	CHD3 CHD4 TP63	1.26e-05	16	100	3	21930775
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 ARHGEF18 PTPN23 BIRC6 ASAP2 SCAPER UBR3 CDC5L EXOC4	1.31e-05	493	100	9	15368895
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	EZR HYOU1 DSP GARS1 PRPF8 HSPA4	1.36e-05	179	100	6	36261009
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	KRT13 SRGAP2 SRGAP1 HSPA4 EXOC4	1.71e-05	110	100	5	27889896
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	EZR RGPD2 HYOU1 DSP GARS1 CCDC80 HUWE1 UBR3 HSPA4 EXOC4	1.78e-05	647	100	10	26618866
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	EZR KRT9 HYOU1 DSP SYNE1 GARS1 CHD4 HUWE1 PRPF8 SPAG17 HSPA4	2.13e-05	807	100	11	30575818
Pubmed	Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.	KCNIP2 KCNIP4	2.45e-05	3	100	2	18957440
Pubmed	Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.	TANC2 TANC1	2.45e-05	3	100	2	38092135
Pubmed	Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.	ATR CDC5L	2.45e-05	3	100	2	19633697
Pubmed	EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells.	ATR DNA2	2.45e-05	3	100	2	38721777
Pubmed	Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.	SRGAP2 SRGAP1	2.45e-05	3	100	2	19137586
Pubmed	The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.	CHD3 CHD4	2.45e-05	3	100	2	32658897
Pubmed	CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.	LRRK2 CADPS2	2.45e-05	3	100	2	28647363
Pubmed	Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm.	HUWE1 HSPA4	2.45e-05	3	100	2	34909679
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	CHD4 PRPF8 PNISR TRRAP CACTIN CDC5L HSPA4	2.67e-05	300	100	7	28561026
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	KRT9 KRT13 DSP GARS1 CHD3 CHD4 PRPF8 ASAP2 MRPS9 DYNC1LI1 CHD6 CDC5L HSPA4	2.69e-05	1153	100	13	29845934
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KRT9 PTPN23 CHD3 CHD4 PRPF8 UPF2	2.70e-05	202	100	6	24639526
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	PRPSAP1 PTPN23 CHD4 HUWE1 PRPF8 TRRAP BIRC6 UPF2 MRPS9 EXOC4	3.65e-05	704	100	10	29955894
Pubmed	FAM188B enhances cell survival via interaction with USP7.	KRT9 KRT13 DSP PRPF8	3.81e-05	65	100	4	29795372
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	EZR HYOU1 SYNE1 GARS1 SAV1 CHD3 PRPF8 CDC5L HSPA4 CPSF3	4.11e-05	714	100	10	28302793
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	DSP PRPF8 CDC5L HSPA4 CPSF3 USP6NL	4.35e-05	220	100	6	24550385
Pubmed	Differential distribution of KChIPs mRNAs in adult mouse brain.	KCNIP2 KCNIP4	4.89e-05	4	100	2	15363885
Pubmed	Characterization of the CHD family of proteins.	CHD3 CHD4	4.89e-05	4	100	2	9326634
Pubmed	A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.	TP63 HSPA4	4.89e-05	4	100	2	11238924
Pubmed	LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.	LRRK2 NOD1	4.89e-05	4	100	2	27830463
Pubmed	CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.	LRRK2 HSPA4	4.89e-05	4	100	2	19196961
Pubmed	Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.	KCNIP2 KCNIP4	4.89e-05	4	100	2	16112838
Pubmed	Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.	EZR LRRK2	4.89e-05	4	100	2	19890007
Pubmed	Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.	ATR HSPA4	4.89e-05	4	100	2	21566061
Pubmed	Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells.	KCNIP2 KCNIP4	4.89e-05	4	100	2	18393943
Pubmed	NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.	CHD3 CHD4	4.89e-05	4	100	2	16574654
Pubmed	A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.	HUWE1 HSPA4	4.89e-05	4	100	2	21298030
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 SYNE1 PTPN23 BIRC6 CHD6 CDC5L	4.93e-05	225	100	6	12168954
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EZR HYOU1 ATR DSP SYNE1 GARS1 CHD4 HUWE1 PRPF8 MRPS9 DYNC1LI1 CDC5L HSPA4 CPSF3	5.78e-05	1425	100	14	30948266
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	ATR DSP CHD4 PRPF8 CCNH CDC5L DNA2	5.90e-05	340	100	7	24332808
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	USP24 CHD4 HUWE1 PRPF8 TRRAP BIRC6 HSPA4	6.35e-05	344	100	7	30333137
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	GARS1 CHD4 DYNC1LI1 HSPA4 CPSF3 EXOC4	6.57e-05	237	100	6	29564676
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CHD3 CHD4 PRPF8 TRRAP BIRC6 NGDN UPF2 SCAPER CDC5L EXOC4	6.83e-05	759	100	10	35915203
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	TRRAP UPF2 HSPA4	7.98e-05	29	100	3	20371770
Pubmed	Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.	KCNIP2 KCNIP4	8.14e-05	5	100	2	15184042
Pubmed	Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation.	TP63 HSPA4	8.14e-05	5	100	2	33619536
Pubmed	Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.	ATR UPF2	8.14e-05	5	100	2	16086026
Pubmed	The genes for the inter-alpha-inhibitor family share a homologous organization in human and mouse.	ITIH3 TYRP1	8.14e-05	5	100	2	1371941
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 KRT9 GGA2 LRRK2 APBB2 CHD4 HUWE1 BIRC6 KIF20A MRPS9	8.29e-05	777	100	10	35844135
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	PRPSAP1 UBR1 HUWE1 PRPF8 UPF2 MRPS9 CDC5L DNA2	8.31e-05	486	100	8	30940648
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ATR DSP CHD3 CHD4 PRPF8 PNISR TRRAP NGDN KIF20A CACTIN CHD6 CDC5L CPSF3	8.70e-05	1294	100	13	30804502
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HYOU1 DSP GARS1 USP24 PTPN23 PRPF8 TRRAP BIRC6 NGDN TOLLIP TOR3A HSPA4 CPSF3	8.90e-05	1297	100	13	33545068
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	GARS1 PRPF8 TANC1 CDC5L HSPA4	9.09e-05	156	100	5	32850835
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	EZR UBR1 HYOU1 DSP GARS1 KIF20A CDC5L HSPA4	9.30e-05	494	100	8	26831064
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	DSP CHD3 PRPF8 KIF20A PLA2G4A TANC1	1.00e-04	256	100	6	33397691
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EZR KRT9 HYOU1 DSP GARS1 CHD4 SRGAP2 HUWE1 PRPF8 DYNC1LI1 CDC5L HSPA4	1.16e-04	1149	100	12	35446349
Pubmed	Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.	CHD3 CHD4	1.22e-04	6	100	2	17626165
Pubmed	Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.	KCNIP2 KCNIP4	1.22e-04	6	100	2	20943905
Pubmed	Spatiotemporal dynamics of 5-HT6 receptor ciliary localization during mouse brain development.	WFS1 S100B	1.22e-04	6	100	2	36496200
Pubmed	Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.	UBR1 UBR3	1.22e-04	6	100	2	17462990
Pubmed	Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.	UBR1 UBR3	1.22e-04	6	100	2	10805755
Pubmed	SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.	SRGAP2 SRGAP1	1.22e-04	6	100	2	33514561
Pubmed	Screening of LRRK2 interactants by yeast 2-hybrid analysis.	LRRK2 PTPN23	1.22e-04	6	100	2	19001729
Pubmed	FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.	SRGAP2 SRGAP1	1.22e-04	6	100	2	12736724
Pubmed	Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.	SRGAP2 SRGAP1	1.22e-04	6	100	2	11672528
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	PRPSAP1 RGPD2 KRT13 HYOU1 PTPN23 CHD4 HUWE1 PRPF8 DYNC1LI1	1.31e-04	665	100	9	30457570
Interaction	PAXBP1 interactions	CHD3 CHD4 PRPF8 KIF20A CACTIN DNAJC17 CDC5L	2.38e-06	121	100	7	int:PAXBP1
Interaction	CDC5L interactions	TANC2 ATR DSP SYNE1 USP24 CHD3 CHD4 HUWE1 PRPF8 PNISR CACTIN DNAJC17 DYNC1LI1 CDC5L CPSF3 EXOC4	4.57e-06	855	100	16	int:CDC5L
Interaction	IK interactions	CHD3 CHD4 PRPF8 KIF20A CACTIN TP63 TOLLIP CDC5L	1.18e-05	215	100	8	int:IK
Interaction	PTPN23 interactions	LRRK2 PTPN23 BIRC6 KIF20A TP63 TOLLIP HSPA4	1.63e-05	162	100	7	int:PTPN23
Interaction	ZUP1 interactions	KRT9 KRT13 DSP CHD4 HUWE1 PRPF8 SHCBP1	2.58e-05	174	100	7	int:ZUP1
Interaction	DDX23 interactions	SYNE1 CHD3 CHD4 PRPF8 PNISR TRRAP CACTIN DNAJC17 TP63 CDC5L CPSF3	2.62e-05	480	100	11	int:DDX23
Interaction	PCNT interactions	SYNE1 CHD3 CHD4 SRGAP2 HUWE1 PNISR DYNC1LI1 CDC5L	2.69e-05	241	100	8	int:PCNT
Interaction	AHNAK interactions	EZR DSP LRRK2 CHD4 PRPF8 KIF20A S100B TOLLIP CDC5L	2.93e-05	318	100	9	int:AHNAK
Interaction	GNAL interactions	SRGAP2 TRRAP KIF20A SRGAP1	3.32e-05	37	100	4	int:GNAL
Interaction	NOC4L interactions	CHD3 CHD4 S100B DNAJC17 DUSP29 TOLLIP CDC5L	3.57e-05	183	100	7	int:NOC4L
Interaction	TTC3 interactions	DSP GARS1 HUWE1 CADPS2 HSPA4 EXOC4	3.57e-05	124	100	6	int:TTC3
Interaction	CDKN2A interactions	ATR LRRK2 HUWE1 TRRAP TP63 RIN2 CDC5L CCDC180 HSPA4	4.39e-05	335	100	9	int:CDKN2A
Interaction	KIF13A interactions	HYOU1 HUWE1 TRRAP KIF20A	4.55e-05	40	100	4	int:KIF13A
Interaction	STAB1 interactions	GGA2 KIF20A CDC5L	5.17e-05	15	100	3	int:STAB1
Interaction	DNAJC17 interactions	HYOU1 ANPEP PRPF8 DNAJC17 PLA2G4A CDC5L	5.52e-05	134	100	6	int:DNAJC17
Interaction	OFD1 interactions	HYOU1 DSP GARS1 SAV1 TRRAP CCDC61 S100B HSPA4 EXOC4	5.76e-05	347	100	9	int:OFD1
Interaction	CCDC39 interactions	HYOU1 TRRAP DYNC1LI1	6.33e-05	16	100	3	int:CCDC39
Interaction	WWOX interactions	EZR DSP GARS1 USP24 APBB2 HUWE1 PRPF8 TP63 CDC5L HSPA4 CPSF3 USP6NL	6.40e-05	627	100	12	int:WWOX
Interaction	CAPZA1 interactions	LRRK2 HUWE1 PRPF8 TRRAP KIF20A S100B DYNC1LI1 CDC5L EXOC4	8.66e-05	366	100	9	int:CAPZA1
Interaction	MRE11 interactions	ATR CHD3 CHD4 HUWE1 TRRAP DYNC1LI1 CDC5L CPSF3	9.20e-05	287	100	8	int:MRE11
Interaction	CASP8 interactions	EZR RALGDS LRRK2 CHD3 BIRC6 NOD1 DYNC1LI1	9.58e-05	214	100	7	int:CASP8
Interaction	HNRNPAB interactions	LRRK2 CHD3 CHD4 HUWE1 PRPF8 TRRAP KIF20A TP63 HSPA4	9.60e-05	371	100	9	int:HNRNPAB
Interaction	SMU1 interactions	DSP HUWE1 PRPF8 KIF20A CACTIN DNAJC17 CDC5L	1.38e-04	227	100	7	int:SMU1
Interaction	CASP4 interactions	ANPEP DSP NOD1 PLA2G4A	1.49e-04	54	100	4	int:CASP4
Interaction	POU5F1 interactions	USP34 KRT9 ATR LRRK2 CHD3 CHD4 HUWE1 TRRAP DYNC1LI1 CDC5L TOR3A	1.51e-04	584	100	11	int:POU5F1
Interaction	DDIT4 interactions	LRRK2 HUWE1 HSPA4	1.70e-04	22	100	3	int:DDIT4
Interaction	RCOR1 interactions	USP34 DSP USP24 CHD3 CHD4 HUWE1 BIRC6 CHD6 HSPA4 EXOC4	1.72e-04	494	100	10	int:RCOR1
Interaction	CNTROB interactions	DSP SAV1 TRRAP S100B DUSP29 EXOC4	1.80e-04	166	100	6	int:CNTROB
Interaction	ITGB3 interactions	HUWE1 PRPF8 TRRAP BIRC6 PLA2G4A HSPA4	2.04e-04	170	100	6	int:ITGB3
Interaction	SH2D3C interactions	PRPSAP1 EZR USP34 HYOU1 USP24 EXOC4	2.18e-04	172	100	6	int:SH2D3C
Interaction	RFLNB interactions	TANC2 EZR TRRAP	2.22e-04	24	100	3	int:RFLNB
Interaction	CPSF2 interactions	CHD3 CHD4 NGDN KIF20A CDC5L CPSF3	2.25e-04	173	100	6	int:CPSF2
Interaction	KRT18 interactions	DSP GARS1 CHD4 HUWE1 PRPF8 BIRC6 UPF2 CDC5L HSPA4	2.39e-04	419	100	9	int:KRT18
Interaction	FLG2 interactions	DSP CHD3 CHD4 PRPF8 GMCL1	2.40e-04	112	100	5	int:FLG2
Interaction	NUP210L interactions	TRRAP KIF20A	2.41e-04	5	100	2	int:NUP210L
Interaction	EFTUD2 interactions	PRPSAP1 EZR KRT9 KRT13 DSP GARS1 USP24 CHD3 CHD4 SRGAP2 HUWE1 PRPF8 BIRC6 KIF20A DNAJC17 MRPS9 CDC5L HSPA4	2.53e-04	1449	100	18	int:EFTUD2
Interaction	DSP interactions	HYOU1 DSP CHD3 CHD4 PRPF8 TRRAP KIF20A GMCL1 CDC5L	2.56e-04	423	100	9	int:DSP
Interaction	CDC42 interactions	TANC2 PRPSAP1 UBR1 HYOU1 ATR DSP SYNE1 LRRK2 RFX6 HUWE1 PNISR TRRAP TBC1D8 SRGAP1 DYNC1LI1 CDC5L USP6NL	2.59e-04	1323	100	17	int:CDC42
Interaction	HSP90AB1 interactions	DSP LRRK2 CHD3 HUWE1 PRPF8 KIF20A ASAP2 NOD1 TP63 PLA2G4A CDC5L SPAG17 HSPA4 CCDC144A	2.73e-04	960	100	14	int:HSP90AB1
Interaction	IVNS1ABP interactions	PRPSAP1 CHD3 SRGAP2 TRRAP SRGAP1 TOLLIP	2.78e-04	180	100	6	int:IVNS1ABP
Interaction	CLIP1 interactions	CHD3 CHD4 TRRAP BIRC6 DYNC1LI1 EXOC4	3.04e-04	183	100	6	int:CLIP1
Interaction	H2AC12 interactions	CHD3 CHD4 TRRAP BIRC6 TANC1	3.05e-04	118	100	5	int:H2AC12
Interaction	SIRT7 interactions	USP34 HYOU1 ATR DSP USP24 CHD4 HUWE1 PRPF8 TRRAP BIRC6 HSPA4 CPSF3	3.15e-04	744	100	12	int:SIRT7
Interaction	NXF1 interactions	UBR1 HYOU1 CHD3 PRPF8 PNISR TRRAP TBC1D16 CACTIN UPF2 SHCBP1 MRPS9 PLA2G4A TANC1 DNA2 HSPA4 CPSF3 USP6NL	3.15e-04	1345	100	17	int:NXF1
Interaction	GIGYF2 interactions	TANC2 CHD4 SRGAP2 HUWE1 PRPF8 KIF20A UPF2	3.39e-04	263	100	7	int:GIGYF2
Interaction	SRRM1 interactions	LRRK2 CHD3 CHD4 HUWE1 PRPF8 KIF20A UPF2 CDC5L	3.42e-04	348	100	8	int:SRRM1
Interaction	MYL9 interactions	LRRK2 TRRAP KIF20A TP63	3.44e-04	67	100	4	int:MYL9
Interaction	PHB2 interactions	ATR SYNE1 CHD3 CHD4 HUWE1 ASB14 PRPF8 BIRC6 KIF20A UPF2	3.51e-04	540	100	10	int:PHB2
Interaction	HECTD1 interactions	CHD3 CHD4 SRGAP2 HUWE1 PRPF8 TRRAP BIRC6 NGDN UPF2 SCAPER TOLLIP CDC5L HSPA4 EXOC4	3.51e-04	984	100	14	int:HECTD1
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2 SRGAP2C SRGAP1 SRGAP2B	1.45e-06	23	67	4	1288
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR3	2.81e-04	7	67	2	785
GeneFamily	PHD finger proteins\|NuRD complex	CHD3 CHD4	8.72e-04	12	67	2	1305
GeneFamily	Potassium voltage-gated channel regulatory subunits\|DASH family	KCNIP2 KCNIP4	1.38e-03	15	67	2	858
GeneFamily	Heat shock 70kDa proteins	HYOU1 HSPA4	1.77e-03	17	67	2	583
Coexpression	GSE1432_CTRL_VS_IFNG_6H_MICROGLIA_UP	SYNE1 DGKA CHD4 PRPF8 TBC1D16 GMCL1 S100B MICAL2	1.02e-06	200	100	8	M3404
Coexpression	LAKE_ADULT_KIDNEY_C14_DISTAL_CONVOLUTED_TUBULE	USP24 APBB2 PNISR SCAPER UBR3 KCNIP4 CADPS2 EXOC4	1.37e-06	208	100	8	M39233
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	TANC2 EZR RALGDS SYNE1 DGKA CHD3 CHD4 PNISR TBC1D8 TBC1D16 S100B NOD1 SRGAP1 ERMARD HSPA4 USP6NL	4.15e-06	1102	100	16	M2369
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	TANC2 EZR RALGDS SYNE1 DGKA CHD3 CHD4 PNISR TBC1D8 TBC1D16 S100B NOD1 SRGAP1 ERMARD HSPA4 USP6NL	5.33e-06	1124	100	16	MM1070
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP	ATR MCM8 GARS1 SRGAP2 SNX13 MICAL2 SHCBP1 MRPS9 SRGAP2B HSPA4 CPSF3	3.54e-05	644	100	11	M10501
Coexpression	GSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP	SYNE1 ARHGEF18 CHD3 GMCL1 NOD1 TANC1	7.61e-05	184	100	6	M9005
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	PRPSAP1 GGA2 HYOU1 ATR WFS1 CHD4 SRGAP2	9.24e-05	276	100	7	M3063
Coexpression	GSE45365_WT_VS_IFNAR_KO_CD11B_DC_MCMV_INFECTION_UP	EZR ARHGEF18 CHD4 PRPF8 CCDC61 CACTIN	9.90e-05	193	100	6	M9975
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	USP34 ATR USP24 APBB2 SRGAP2 PNISR TRRAP SNX13 ASAP2 UPF2 MICAL2 RIN2	1.03e-04	856	100	12	M4500
Coexpression	GSE11057_PBMC_VS_MEM_CD4_TCELL_UP	ANPEP LRRK2 P2RY13 TBC1D8 ASAP2 PLA2G4A	1.11e-04	197	100	6	M3120
Coexpression	GSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP	EZR GGA2 HYOU1 SYNE1 SAV1 TOLLIP	1.14e-04	198	100	6	M6522
Coexpression	GSE40666_STAT1_KO_VS_STAT4_KO_CD8_TCELL_UP	PRPSAP1 ARHGEF18 FPGT NGDN ASAP2 CDADC1	1.17e-04	199	100	6	M9220
Coexpression	GSE27786_BCELL_VS_NKCELL_UP	USP34 LRRK2 DGKA GMCL1 CHD6 FHIP1A	1.20e-04	200	100	6	M4805
Coexpression	GSE24574_BCL6_HIGH_TFH_VS_TFH_CD4_TCELL_DN	EZR USP34 SYNE1 DGKA CHD3 PNISR	1.20e-04	200	100	6	M8331
Coexpression	GSE5503_LIVER_DC_VS_PLN_DC_ACTIVATED_ALLOGENIC_TCELL_DN	DSP BIRC6 MRPS9 UBR3 DNA2 HSPA4	1.20e-04	200	100	6	M6993
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EZR SYNE1 CCDC80 TBC1D8 CFAP45 VWA3B SPAG17 CCDC180	1.54e-08	197	100	8	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EZR SYNE1 CCDC80 TBC1D8 CFAP45 VWA3B SPAG17 CCDC180	1.54e-08	197	100	8	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EZR SYNE1 CCDC80 TBC1D8 CFAP45 VWA3B SPAG17 CCDC180	1.54e-08	197	100	8	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EZR SYNE1 CCDC80 TBC1D8 CFAP45 VWA3B SPAG17 CCDC180	1.54e-08	197	100	8	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PNISR TBC1D8 TBC1D16 CCNH UPF2 SCAPER SRGAP2B	2.38e-08	135	100	7	b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TANC2 LRRK2 TBC1D16 MICAL2 PLA2G4A CADPS2 FHIP1A	1.98e-07	184	100	7	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-C1ql2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KRT9 DSP BEST3 DUSP29 VWA3B FHIP1A	2.28e-07	114	100	6	f48fd7d378626eb7ef972ff1df87dd6149cb355c
ToppCell	IPF-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	LRRK2 P2RY13 ARHGEF18 SRGAP2 TBC1D8 SRGAP2C SRGAP2B	2.46e-07	190	100	7	f9c2a13c7f6460e3b348581be855b7281c8f70b5
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	P2RY13 SRGAP2 SMCO2 TBC1D8 SRGAP2C SRGAP2B USP6NL	2.94e-07	195	100	7	2f2e29089a8cb748d2c1329c5c8465165b25bc8b
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	P2RY13 SRGAP2 SMCO2 TBC1D8 SRGAP2C SRGAP2B USP6NL	2.94e-07	195	100	7	c9469e2d31beb30ebb64b3f0a5239e23119fbaa5
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 APBB2 SCAPER TANC1 CADPS2 FHIP1A EXOC4	3.26e-07	198	100	7	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP34 APBB2 BIRC6 SCAPER UBR3 CADPS2 EXOC4	3.37e-07	199	100	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-C1ql2-Excitatory_Neuron.Slc17a7.C1ql2-Cck_(Dentate_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KRT9 DSP BEST3 DUSP29 VWA3B FHIP1A	4.72e-07	129	100	6	08ecebb7f09d105dfdfd2191fc310910d3baec0f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TANC2 DSP DGKA PLEKHH1 SRGAP1 TANC1	3.19e-06	179	100	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	USP24 APBB2 ASAP2 KCNIP4 MAP3K15 CADPS2	3.19e-06	179	100	6	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HYOU1 WFS1 ZNF446 CACTIN TP63 SHCBP1	3.62e-06	183	100	6	dd15e1463a0d57d14800de0df0645c81c56926ae
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HYOU1 WFS1 ZNF446 CACTIN TP63 SHCBP1	3.62e-06	183	100	6	8ace19c38b89556d2504258a63aa5a2b14f5cd36
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TANC2 LRRK2 MICAL2 PLA2G4A CADPS2 FHIP1A	3.98e-06	186	100	6	e83718fabb057100835d3357df407f283d23fe16
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ASAP2 SHCBP1 KCNIP4 MAP3K15 CADPS2	4.10e-06	187	100	6	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TANC2 LRRK2 MICAL2 PLA2G4A CADPS2 FHIP1A	4.23e-06	188	100	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HYOU1 P2RY13 CCDC80 SRGAP2 SNX13 RIN2	4.36e-06	189	100	6	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	COPD-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	LRRK2 ARHGEF18 SRGAP2 TBC1D8 SRGAP2C SRGAP2B	4.49e-06	190	100	6	aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GGA2 LRRK2 USP24 SRGAP2 SRGAP2C UPF2	4.49e-06	190	100	6	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	EZR DSP KCNIP2 CLEC17A TOR3A USP6NL	4.49e-06	190	100	6	60bb6aaea9691d07295f61c14d1650f5041a0f9c
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	EZR DSP KCNIP2 CLEC17A HSPA4 USP6NL	4.49e-06	190	100	6	e63945fa1dcd58bee129f1dd0c23b64a76241554
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ADAM23 SHCBP1 KCNIP4 MAP3K15 CADPS2	4.49e-06	190	100	6	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	EZR DSP KCNIP2 CLEC17A HSPA4 USP6NL	4.49e-06	190	100	6	fa65bc5a178ae0c80a9bd4b282e4539493128a64
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	UBR1 HYOU1 HUWE1 BIRC6 DNA2 EXOC4	4.63e-06	191	100	6	9454f642c3621370fa23640b631301346b300950
ToppCell	IPF-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	SRGAP2 S100B SRGAP2C SRGAP1 PLA2G4A SRGAP2B	4.63e-06	191	100	6	9fda87fb6bc5b8b6c0214ec909ebbc9f3f65319b
ToppCell	COPD-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SRGAP2 S100B SRGAP2C SRGAP1 SRGAP2B FHIP1A	4.77e-06	192	100	6	984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC2\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRRK2 P2RY13 SRGAP2 S100B SRGAP1 SRGAP2B	4.77e-06	192	100	6	90274b85f3d612b6a6d435860cd6d049ddeb1d96
ToppCell	IPF-Myeloid-ncMonocyte\|IPF / Disease state, Lineage and Cell class	LRRK2 ARHGEF18 SRGAP2 TBC1D8 SRGAP2C SRGAP2B	4.77e-06	192	100	6	e9fb8c57d8094f70fb492909b2bec40aa5f2e5b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ADAM23 SHCBP1 KCNIP4 MAP3K15 CADPS2	4.77e-06	192	100	6	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	healthy_donor-Lymphocytic-B_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	EZR GGA2 DSP SAV1 CLEC17A USP6NL	4.77e-06	192	100	6	7d9e5772b6e531b50ed4e4d6304ef11235f27f37
ToppCell	IPF-Myeloid-cDC2\|IPF / Disease state, Lineage and Cell class	SRGAP2 S100B SRGAP2C SRGAP1 PLA2G4A SRGAP2B	4.77e-06	192	100	6	fe1de692fec48cba4a9bbc6eaa257260e8b4e800
ToppCell	healthy_donor-Lymphocytic-B_cell-\|healthy_donor / Disease condition, Lineage, Cell class and subclass	EZR GGA2 DSP SAV1 CLEC17A USP6NL	4.77e-06	192	100	6	975312f9d6cede4d4f5b737e481e5c73accc8c50
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TANC2 SYNE1 LRRK2 MICAL2 CADPS2 FHIP1A	4.92e-06	193	100	6	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	COPD-Myeloid-ncMonocyte\|COPD / Disease state, Lineage and Cell class	LRRK2 ARHGEF18 SRGAP2 TBC1D8 SRGAP1 SRGAP2B	4.92e-06	193	100	6	936ca95995599356b794fba32bfd82d8de339365
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LRRK2 SRGAP2 TBC1D8 SRGAP2C RIN2 SRGAP2B	4.92e-06	193	100	6	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	TANC2 ADAM23 ASAP2 KCNIP4 MAP3K15 CADPS2	4.92e-06	193	100	6	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	Control-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SRGAP2 S100B SRGAP2C SRGAP1 SRGAP2B FHIP1A	4.92e-06	193	100	6	4cb938c346cc32ec122d11e6b9f25db20e0f7ff6
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TANC2 SYNE1 LRRK2 MICAL2 CADPS2 FHIP1A	4.92e-06	193	100	6	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	PBMC-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EZR GGA2 DSP SAV1 CLEC17A USP6NL	5.06e-06	194	100	6	a8daf73c186a15adb9ea02793d4bd9cb35c66290
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY13 SRGAP2 TBC1D16 SRGAP2C SRGAP1 SRGAP2B	5.06e-06	194	100	6	7c7091de47359760003e910cfbe63db5c99410d6
ToppCell	PBMC-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	EZR GGA2 DSP SAV1 CLEC17A USP6NL	5.06e-06	194	100	6	39121c7d537ac103f6959271d814fd327be7114f
ToppCell	PBMC-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	EZR GGA2 DSP SAV1 CLEC17A USP6NL	5.06e-06	194	100	6	60542304899b99caa38e4abf6b71ba986fa6c399
ToppCell	Control-Lymphoid_B-B_naive\|Control / Disease group, lineage and cell class	GGA2 DSP APBB2 SAV1 CLEC17A USP6NL	5.06e-06	194	100	6	4f9600960a287cfc020c06b4af3528d4e5797916
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TANC2 EZR SYNE1 LRRK2 MICAL2 CADPS2	5.06e-06	194	100	6	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	PBMC-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EZR GGA2 DSP SAV1 CLEC17A USP6NL	5.06e-06	194	100	6	ad9a8cc57f54bdec4cd6990b2cace947b7a163c9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EZR GGA2 SRGAP2 UPF2 TOR3A USP6NL	5.22e-06	195	100	6	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EZR GGA2 SRGAP2 UPF2 TOR3A USP6NL	5.22e-06	195	100	6	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	LRRK2 SRGAP2 TBC1D8 SRGAP2C RIN2 SRGAP2B	5.22e-06	195	100	6	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 KRT13 USP24 P2RY13 SRGAP2 PNISR	5.22e-06	195	100	6	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 APBB2 SCAPER CADPS2 FHIP1A EXOC4	5.37e-06	196	100	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Healthy_donor-B_naive\|Healthy_donor / disease group, cell group and cell class (v2)	EZR DSP APBB2 SAV1 CLEC17A USP6NL	5.37e-06	196	100	6	cf254b1466357984201595fa32408d659eb741ef
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GGA2 DSP APBB2 SAV1 CLEC17A USP6NL	5.37e-06	196	100	6	d7e6c89cb49933b4a86d26d15f6772f2481d37ef
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GGA2 DSP APBB2 SAV1 CLEC17A USP6NL	5.37e-06	196	100	6	fcbfd8c4771d99a45fc53e482ef98edabe8ef591
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GGA2 DSP APBB2 SAV1 CLEC17A USP6NL	5.37e-06	196	100	6	f45cb8f714ae7ac800768df65f299b98a2d42962
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EZR GGA2 DSP SAV1 CLEC17A USP6NL	5.53e-06	197	100	6	f7a8440d2b8b17d9726c6fe3dd383effbfebab13
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SYNE1 USP24 DGKA CHD3 PNISR	5.53e-06	197	100	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	COVID-19_Mild-Lymphoid_B\|COVID-19_Mild / Disease group, lineage and cell class	EZR GGA2 DSP SAV1 CLEC17A USP6NL	5.53e-06	197	100	6	ff25c0e184bd0f068014bc3f5eba3aee17511b87
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	EZR GGA2 DSP SAV1 CLEC17A USP6NL	5.53e-06	197	100	6	7cae4f3eabfebce101de7bb7defb17d6c5360b58
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TANC2 DSP LRRK2 PLA2G4A CADPS2 FHIP1A	5.69e-06	198	100	6	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Airway-Club\|LPS_only / Treatment groups by lineage, cell group, cell type	EZR ANPEP TDRD9 DSP TP63 SPAG17	5.86e-06	199	100	6	165ac94b2d56072ad43358b5127d77555221e2d8
ToppCell	Sepsis-ICU-SEP-Lymphocyte-B-Plasmablast\|ICU-SEP / Disease, condition lineage and cell class	HYOU1 KIF20A TP63 SHCBP1 TOR3A CCDC180	5.86e-06	199	100	6	09f02aaedf19f895a7b6f8eb939fd346b1df75f1
ToppCell	severe-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EZR DSP APBB2 SAV1 CLEC17A USP6NL	6.03e-06	200	100	6	0e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCell	mild-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EZR GGA2 DSP SAV1 CLEC17A USP6NL	6.03e-06	200	100	6	222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCell	severe-B_naive\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EZR DSP APBB2 SAV1 CLEC17A USP6NL	6.03e-06	200	100	6	306df1f498ac2188eaf9f2a8d002bb73bdb9642d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Slco2a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANO4 S100B TANC1 CADPS2 FHIP1A	1.26e-05	133	100	5	9d7a08170d38ae9b2ff10a0fa505aeb3aae2824d
ToppCell	ILEUM-non-inflamed-(5)_Plasma-(5)_IgM_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EZR CHD4 UPF2 PLA2G4A	1.88e-05	70	100	4	aa63c1b77a9fb15e75835cb3781f2d890f3fe328
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT13 TDRD9 CCDC80 KCNIP2 TP63	3.06e-05	160	100	5	8590281165eab6514a9f6a022b900d4c222c1044
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	EZR GGA2 SAV1 CHD4 USP6NL	3.35e-05	163	100	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	ICU-SEP-Lymphocyte-B-Plasmablast\|ICU-SEP / Disease, Lineage and Cell Type	KIF20A TP63 SHCBP1 TOR3A CCDC180	3.65e-05	166	100	5	98ce43e14133418f676f1c88c001add9e28259a7
ToppCell	lung-Ciliated_Epithelia\|lung / shred on tissue and cell subclass	CFAP45 CDADC1 ERICH2 SPAG17 CCDC180	3.76e-05	167	100	5	26cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHD3 PNISR SHCBP1 CADPS2 SPAG17	4.09e-05	170	100	5	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT9 DSP RFX6 TP63 KEL	4.09e-05	170	100	5	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT9 DSP RFX6 TP63 KEL	4.09e-05	170	100	5	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CACTIN CFAP45 VWA3B SPAG17 ERMARD	4.21e-05	171	100	5	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP ADAM23 LRRK2 TBC1D16 CCDC180	4.32e-05	172	100	5	356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP ADAM23 LRRK2 TBC1D16 CCDC180	4.32e-05	172	100	5	46fadeee483fdf8402df92ec98575a09c6c15b16
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GGA2 DSP SAV1 CLEC17A USP6NL	4.32e-05	172	100	5	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP ADAM23 LRRK2 TBC1D16 CCDC180	4.32e-05	172	100	5	438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	EZR GGA2 SAV1 CHD4 USP6NL	4.45e-05	173	100	5	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HYOU1 WFS1 KIF20A SHCBP1 CADPS2	4.82e-05	176	100	5	dc4e939a07bad21ab36181f9588df3fa662f9a92
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TANC2 LRRK2 PLA2G4A CADPS2 FHIP1A	5.23e-05	179	100	5	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRPSAP1 TRIML2 ADAM23 CFAP45	5.29e-05	91	100	4	b0658e020f80e56fab9d2aa07e321d9b33d7af2c
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	TANC2 SYNE1 LRRK2 MICAL2 CADPS2	5.37e-05	180	100	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	Endothelial-B-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	ADAM23 WFS1 CCDC80 KEL DNA2	5.51e-05	181	100	5	4fe0215d08f03d4e24749d70fce01b7aa22906fd
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	USP34 DGKA HUWE1 CCNH SRGAP2B	5.51e-05	181	100	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRIML2 ADAM23 S100B CFAP45	5.76e-05	93	100	4	93a8d3ad978e4cd450f7a69a4cbac1a59038e80d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	APBB2 SRGAP2 SRGAP2C TANC1 SRGAP2B	5.80e-05	183	100	5	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	APBB2 SRGAP2 SRGAP2C TANC1 SRGAP2B	5.80e-05	183	100	5	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	USP24 APBB2 ASAP2 MAP3K15 CADPS2	5.80e-05	183	100	5	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	APBB2 SRGAP2 SRGAP2C TANC1 SRGAP2B	5.96e-05	184	100	5	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	EZR USP34 ARHGEF18 UPF2 CLEC17A	6.11e-05	185	100	5	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EZR GGA2 SRGAP2 SRGAP2C UPF2	6.27e-05	186	100	5	55b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRRK2 RFX6 UPF2 SRGAP1 SPAG17	6.27e-05	186	100	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HYOU1 WFS1 KIF20A SHCBP1 CADPS2	6.43e-05	187	100	5	88d20f150df61ef0e3ee0c3e9895b094920c4b09
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HYOU1 WFS1 KIF20A SHCBP1 CADPS2	6.43e-05	187	100	5	158c2c003fd225ba61793fb06eece232fb063d05
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EZR USP24 APBB2 KCNIP4 FHIP1A	6.43e-05	187	100	5	f124d2c699b717b7c02a1a70493f515b83dc2f4c
Disease	neurodegenerative disease (implicated_via_orthology)	UBR1 GGA2 LRRK2 TOLLIP UBR3	1.32e-04	145	99	5	DOID:1289 (implicated_via_orthology)
Disease	resting heart rate	KRT9 DSP NGDN MICAL2 TANC1	1.50e-04	149	99	5	EFO_0004351
Disease	Seckel syndrome (implicated_via_orthology)	ATR DNA2	2.31e-04	7	99	2	DOID:0050569 (implicated_via_orthology)
Disease	Intellectual Disability	TANC2 RALGDS SYNE1 PTPN23 CHD3 TRRAP SCAPER	7.85e-04	447	99	7	C3714756
Disease	reticulocyte measurement	PRPSAP1 USP34 ATR PRPF8 BIRC6 SNX13 TBC1D8 NOD1 MICAL2 KEL HSPA4	8.15e-04	1053	99	11	EFO_0010700
Disease	stroke	CHD3 PRPF8 MICAL2 CDC5L	1.43e-03	144	99	4	EFO_0000712
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	MCM8 HSPA4	1.65e-03	18	99	2	EFO_1000649, HP_0000131
Disease	lean mass-adjusted fat body mass	RIN2 CDC5L	1.65e-03	18	99	2	EFO_0009890
Disease	lung cancer (is_implicated_in)	ATR CHD4 TP63	2.00e-03	74	99	3	DOID:1324 (is_implicated_in)
Disease	osteoarthritis, knee	KRT9 NOD1 PLA2G4A KCNIP4	2.01e-03	158	99	4	EFO_0004616
Disease	nose morphology measurement, mouth morphology measurement	ANO4 DNA2	2.24e-03	21	99	2	EFO_0007843, EFO_0007955
Disease	Seckel syndrome	ATR DNA2	2.46e-03	22	99	2	C0265202
Disease	blood pressure	SYNE1 EXOC4	2.46e-03	22	99	2	EFO_0004325
Disease	reticulocyte count	PRPSAP1 USP34 ATR PRPF8 BIRC6 TBC1D8 NOD1 MICAL2 KEL HSPA4	2.69e-03	1045	99	10	EFO_0007986
Disease	Ovarian Serous Adenocarcinoma	LRRK2 TRRAP	2.69e-03	23	99	2	C1335177
Disease	chronic widespread pain	SNX13 ASAP2	2.69e-03	23	99	2	EFO_0010099
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	TRIML2 SNX13	2.93e-03	24	99	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	cognitive function measurement	TANC2 USP34 DSP RFX6 FPGT BIRC6 TYRP1 ASAP2 SRGAP1 KCNIP4 VWA3B EXOC4	3.08e-03	1434	99	12	EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
DMLYLMENLDTKETD	BEST3	641	Q8N1M1
EAKEFFTLIEEMLLM	ERICH2	101	A1L162
LLEKQQIYLEMAEMG	ARHGEF18	831	Q6ZSZ5
MAEIDARLKALQEYM	CCDC61	491	Q9Y6R9
SEELIKKEMITMLHY	CDC5L	571	Q99459
EEMKYLELMIVNDHK	ADAM23	296	O75077
EGKDMYLILENDMLS	APBB2	466	Q92870
ITMESYLSESLMLKE	CCNH	226	P51946
LFLQLMLEDEKVTMF	BIRC6	3811	Q9NR09
MLYTETDLEESMDKI	CPSF3	121	Q9UKF6
LKDLMVLNDVYRVMA	ANPEP	431	P15144
ALQYTLKDEVMLRML	ASB14	426	A6NK59
IKEYEMLFLVSNEEM	CDADC1	236	Q9BWV3
KYLIQEMMYEAELER	ANO4	921	Q32M45
ESVIMLNMEKLENEY	CCDC180	1076	Q9P1Z9
LMMSLLKDDVYCELA	CCDC80	166	Q76M96
LFVMQVEMDIYTALK	GMCL1	266	Q96IK5
SYLEKILSKNMELME	PAAT	376	Q9H8K7
MLLDEYILLAMETQF	RFX6	526	Q8HWS3
LYSEEKAKLLREMMA	PTPN23	371	Q9H3S7
LYIENEGKMIMQDKL	HSPA4	596	P34932
MLMEFSLKDLYAIQE	MCM8	381	Q9UJA3
MQYETLQEELMALKK	KRT9	276	P35527
EEALDVDRMVLYKMK	ASAP2	41	O43150
EMQIESLNEELAYMK	KRT13	226	P13646
EIMAEDDQVFLMKLQ	DYNC1LI1	366	Q9Y6G9
MLEYMEQLQEEDLKD	CFAP45	286	Q9UL16
ITKEEMLDIMKAIYD	KCNIP4	176	Q6PIL6
ITKEEMLDIMKSIYD	KCNIP2	196	Q9NS61
DKIILQMMRVAEYLD	DGKA	136	P23743
EELLLEEIYMDTIME	NOD1	151	Q9Y239
KVAMDDYLKNVMLER	LRRK2	701	Q5S007
EKEALYALTVLEMCM	GGA2	76	Q9UJY4
LMDYILNVMKFVESI	HUWE1	766	Q7Z6Z7
YLKNTLVADLIMTLM	P2RY13	81	Q9BPV8
YEMLLKIKESLELMQ	TP63	411	Q9H3D4
DVLQMLLTEYLDMKN	EXOC4	391	Q96A65
LYAALKMESMEIIEE	ATR	396	Q13535
MLFLLIEEQAKDAAM	FHIP1A	71	Q05DH4
TDETKIEQLKMYEML	FHIP1A	111	Q05DH4
IEAKMMALDREVQYL	HYOU1	891	Q9Y4L1
YLMIHKDMTLVDAIQ	DUSP29	161	Q68J44
NEKDMEMICRALLVY	CHD6	1126	Q8TD26
IFSQMTKMLDLLEDF	CHD3	1081	Q12873
MRQEDYMKTIADLEL	DSP	571	P15924
ENFMLLIEQLRMEYK	CCDC144B	616	Q3MJ40
FIAKDMENMYIEELR	CADPS2	296	Q86UW7
MAVTKELLQMDLYAL	DNAJC17	1	Q9NVM6
LTDLVMLDTAMKDYL	RALGDS	571	Q12967
NTAVMELLIMAYALK	PRPSAP1	71	Q14558
MEDLLEDIQVYMELE	CACTIN	341	Q8WUQ7
YEVLSVLEEVMMKSA	ERMARD	251	Q5T6L9
NAMLEYLKIAQDLEM	EZR	186	P15311
ENFMLLIEQLRMEYK	CCDC144A	616	A2RUR9
IFSQMTKMLDLLEDF	CHD4	1071	Q14839
MEQLNELELLMEKSF	DNA2	1	P51530
SVVECKEVLMMLDNY	SCAPER	126	Q9BY12
SIEEMLIYKDVEDMI	FPGT	576	O14772
KLMRYESELLIMAQE	MICAL2	1861	O94851
EDFIQALDKMMLENL	UPF2	1111	Q9HAU5
VLEITLMDANYVMDE	PLA2G4A	86	P47712
QDYDAMVKLVETLEM	MAP3K15	296	Q6ZN16
NALYVRMLAELDMLK	SNX13	506	Q9Y5W8
HEDLMKVLNELYTVM	SRGAP1	151	Q7Z6B7
SELHLMKMEFLELKY	SYNE1	496	Q8NF91
AVSLIQMFDDLDMKE	TDRD9	356	Q8NDG6
VKEMLKSVMQELEDY	RGPD2	741	P0DJD1
MKEMEKALQERDYIF	ITIH3	536	Q06033
YITEMEMLLNEKGEF	GARS1	526	P41250
MSELEKAMVALIDVF	S100B	1	P04271
IILLQKLMEEGNVMY	TANC1	1286	Q9C0D5
IILLSKLMEEGDMFY	TANC2	1241	Q9HCD6
DDLMKVLNELYSVMK	SRGAP2C	151	P0DJJ0
DDLMKVLNELYSVMK	SRGAP2B	151	P0DMP2
SMVEGLKLYSEMEQL	SHCBP1	281	Q8NEM2
NYILKKEDELQEMMV	SPAG17	1791	Q6Q759
TLIKYQELMEELRML	CLEC17A	191	Q6ZS10
MLESRFEKMYEKIDL	PRPF8	976	Q6P2Q9
LLFMKELEQIVKMYE	SAV1	341	Q9H4B6
KLATELEEMFQEMLQ	TRIML2	146	Q8N7C3
MLELDTEIEYMMELL	RIN2	711	Q8WYP3
YHLLRLEKDMQEMLQ	TYRP1	226	P17643
LMKLSMEELVEFFQE	USP6NL	311	Q92738
SFLEVKDQLLLMYLM	NGDN	51	Q8NEJ9
EEMLVEKLSDLDYMQ	MRPS9	206	P82933
SMYGKEELLQVVEAM	KIF20A	556	O95235
DIMYNGEMNEKIKLL	TBC1D8	906	O95759
VNSMKELYLLMEEEE	SOGA1	701	O94964
DDLMKVLNELYSVMK	SRGAP2	151	O75044
YMEKDEMLGATLILA	TBC1D16	66	Q8TBP0
DKEGMINLVMSYALL	TOLLIP	161	Q9H0E2
EMYDKDIIMLQIGAS	UBR1	686	Q8IWV7
ELLSAKLRMYQMEAE	SMCO2	226	A6NFE2
ELALEMAALMAQVEY	PLEKHH1	1131	Q9ULM0
SKEQMLEMLVLEQFL	ZNF446	61	Q9NWS9
LIDQMDEYLKKMGRD	USP24	1781	Q9UPU5
YMMESCLIKSELQDE	UBR3	476	Q6ZT12
EYQMMLLTKMLLTEI	PNISR	331	Q8TF01
TLLELQKMFTYLMES	USP34	1936	Q70CQ2
LEKMQDLYSESLIMD	VWA3B	691	Q502W6
EILAGKMYIQQAMEL	VWA3B	986	Q502W6
LLYKEETLDEIAQMM	TOR3A	356	Q9H497
LCNMTFLKEYMEEEI	TRRAP	1726	Q9Y4A5
IMEIKEYLIDMASRA	WFS1	296	O76024
EYLKNMSQLVEEMLL	KEL	341	P23276