Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DZF	STRBP ZFR2 ZFR	2.44e-06	5	118	3	SM00572
Domain	DZF_dom	STRBP ZFR2 ZFR	2.44e-06	5	118	3	IPR006561
Domain	DZF	STRBP ZFR2 ZFR	2.44e-06	5	118	3	PF07528
Domain	DZF	STRBP ZFR2 ZFR	2.44e-06	5	118	3	PS51703
Domain	K_chnl_volt-dep_Kv2	KCNB2 KCNB1	3.96e-05	2	118	2	IPR003973
Domain	Kv2channel	KCNB2 KCNB1	3.96e-05	2	118	2	PF03521
Domain	DDT	BAZ2B BAZ2A	2.36e-04	4	118	2	PF02791
Domain	AAA	ABCA3 VPS4A PEX6 DNAH5 TAP1 DYNC1H1	3.07e-04	144	118	6	SM00382
Domain	AAA+_ATPase	ABCA3 VPS4A PEX6 DNAH5 TAP1 DYNC1H1	3.07e-04	144	118	6	IPR003593
Domain	DDT	BAZ2B BAZ2A	3.91e-04	5	118	2	SM00571
Domain	DDT_dom	BAZ2B BAZ2A	3.91e-04	5	118	2	IPR018501
Domain	WHIM2_dom	BAZ2B BAZ2A	3.91e-04	5	118	2	IPR028941
Domain	WSD	BAZ2B BAZ2A	3.91e-04	5	118	2	PF15613
Domain	SCAN	ZNF444 ZSCAN25 ZNF24 ZNF197	4.32e-04	56	118	4	SM00431
Domain	SCAN_BOX	ZNF444 ZSCAN25 ZNF24 ZNF197	4.94e-04	58	118	4	PS50804
Domain	SCAN	ZNF444 ZSCAN25 ZNF24 ZNF197	4.94e-04	58	118	4	PF02023
Domain	SCAN_dom	ZNF444 ZSCAN25 ZNF24 ZNF197	4.94e-04	58	118	4	IPR003309
Domain	Retrov_capsid_C	ZNF444 ZSCAN25 ZNF24 ZNF197	5.27e-04	59	118	4	IPR008916
Domain	Bromodomain_CS	BAZ2B BAZ2A PHIP	5.75e-04	26	118	3	IPR018359
Domain	DDT	BAZ2B BAZ2A	5.84e-04	6	118	2	PS50827
Domain	-	EVPL MACF1	5.84e-04	6	118	2	3.90.1290.10
Domain	Plectin	EVPL MACF1	8.14e-04	7	118	2	PF00681
Domain	Plectin_repeat	EVPL MACF1	8.14e-04	7	118	2	IPR001101
Domain	PLEC	EVPL MACF1	8.14e-04	7	118	2	SM00250
Domain	DHC_N1	DNAH5 DYNC1H1	1.08e-03	8	118	2	PF08385
Domain	-	BAZ2B BAZ2A	1.08e-03	8	118	2	3.30.890.10
Domain	Dynein_heavy_dom-1	DNAH5 DYNC1H1	1.08e-03	8	118	2	IPR013594
Domain	-	GLB1L2 IDUA GUSB	1.39e-03	35	118	3	3.20.20.80
Domain	BROMODOMAIN_1	BAZ2B BAZ2A PHIP	1.63e-03	37	118	3	PS00633
Domain	Bromodomain	BAZ2B BAZ2A PHIP	1.77e-03	38	118	3	PF00439
Domain	Glyco_hydro_catalytic_dom	GLB1L2 IDUA GUSB	1.77e-03	38	118	3	IPR013781
Domain	MBD	BAZ2B BAZ2A	2.10e-03	11	118	2	SM00391
Domain	MBD	BAZ2B BAZ2A	2.10e-03	11	118	2	PS50982
Domain	Methyl_CpG_DNA-bd	BAZ2B BAZ2A	2.10e-03	11	118	2	IPR001739
Domain	MBD	BAZ2B BAZ2A	2.10e-03	11	118	2	PF01429
Domain	DNA-bd_dom	BAZ2B BAZ2A	2.10e-03	11	118	2	IPR016177
Domain	BROMODOMAIN_2	BAZ2B BAZ2A PHIP	2.20e-03	41	118	3	PS50014
Domain	Bromodomain	BAZ2B BAZ2A PHIP	2.36e-03	42	118	3	IPR001487
Domain	BROMO	BAZ2B BAZ2A PHIP	2.36e-03	42	118	3	SM00297
Domain	-	BAZ2B BAZ2A PHIP	2.36e-03	42	118	3	1.20.920.10
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DYNC1H1	3.43e-03	14	118	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DYNC1H1	3.43e-03	14	118	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DYNC1H1	3.43e-03	14	118	2	IPR013602
Domain	DHC_N2	DNAH5 DYNC1H1	3.43e-03	14	118	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH5 DYNC1H1	3.43e-03	14	118	2	IPR011704
Domain	MT	DNAH5 DYNC1H1	3.43e-03	14	118	2	PF12777
Domain	AAA_8	DNAH5 DYNC1H1	3.43e-03	14	118	2	PF12780
Domain	AAA_5	DNAH5 DYNC1H1	3.43e-03	14	118	2	PF07728
Domain	DHC_fam	DNAH5 DYNC1H1	3.94e-03	15	118	2	IPR026983
Domain	Dynein_heavy	DNAH5 DYNC1H1	3.94e-03	15	118	2	PF03028
Domain	Dynein_heavy_dom	DNAH5 DYNC1H1	3.94e-03	15	118	2	IPR004273
Domain	Glycoside_hydrolase_SF	GLB1L2 IDUA GUSB	4.58e-03	53	118	3	IPR017853
Pubmed	Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.	KCNB2 KCNB1	1.20e-05	2	121	2	28607108
Pubmed	Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.	KCNB2 KCNB1	1.20e-05	2	121	2	29403353
Pubmed	Congenital dyserythropoietic anemia in China: a case report from two families and a review.	CDAN1 SEC23B	1.20e-05	2	121	2	24196372
Pubmed	Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.	KCNB2 KCNB1	1.20e-05	2	121	2	30091655
Pubmed	Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.	KCNB2 KCNB1	1.20e-05	2	121	2	26538660
Pubmed	Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation.	IDUA GUSB	1.20e-05	2	121	2	19751987
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	USP36 ZNF444 STRBP RIOX1 ZSCAN25 WDR3 BAZ2A PHIP	3.19e-05	349	121	8	25665578
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	APC2 WDR81 PREPL CYFIP1 KCNB1 ANAPC1 ICAM5 SEC16A MACF1 ZFR PKN1 CDC73 DYNC1H1	3.24e-05	963	121	13	28671696
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP36 VPS4A PEX6 CRACR2B TYK2 FCSK ARHGAP4 ZNF24 BAZ2A ANAPC1 SEC16A LRP4 MACF1 PHIP	3.53e-05	1116	121	14	31753913
Pubmed	The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.	KCNB2 KCNB1	3.59e-05	3	121	2	23161216
Pubmed	Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.	KCNB2 KCNB1	3.59e-05	3	121	2	8670833
Pubmed	Identification of CDAN1, C15ORF41 and SEC23B mutations in Chinese patients affected by congenital dyserythropoietic anemia.	CDAN1 SEC23B	3.59e-05	3	121	2	29031773
Pubmed	Mechanism of shortened bones in mucopolysaccharidosis VII.	IDUA GUSB	3.59e-05	3	121	2	19375967
Pubmed	Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.	BAZ2B BAZ2A	3.59e-05	3	121	2	28341809
Pubmed	Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.	CDAN1 SEC23B	3.59e-05	3	121	2	21364188
Pubmed	Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.	KCNB2 KCNB1	3.59e-05	3	121	2	22422395
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SMG1 RMND5A STRBP VPS4A SMPD4 RABL3 CCND3 WDR3 GUSB LRP4 MRPS34 ZFR EXOC7 TAP1 COG4 DYNC1H1	4.09e-05	1440	121	16	30833792
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	VPS4A RABL3 FCSK ANAPC1 DNAJC11 MRPS34 CDC73 EXOC7 BRAT1 ADPGK	5.37e-05	606	121	10	36538041
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	RMND5A BAZ2B WDR3 ANAPC1 SEC16A MACF1 CDC73	6.14e-05	282	121	7	23667531
Pubmed	Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.	KCNB2 KCNB1	7.17e-05	4	121	2	30012696
Pubmed	Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice.	IDUA GUSB	7.17e-05	4	121	2	29747998
Pubmed	Distinct cellular expression and subcellular localization of Kv2 voltage-gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans.	KCNB2 KCNB1	7.17e-05	4	121	2	38335058
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	STRBP WDR3 BAZ2A ANAPC1 SEC16A MACF1 ZFR PHIP DYNC1H1 SEC23B	9.94e-05	653	121	10	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP36 SMG1 SMPD4 DZIP1 PREPL ARHGAP4 NRXN2 MED12L LRP4	1.02e-04	529	121	9	14621295
Pubmed	Kv2 channel-AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking.	KCNB2 KCNB1	1.19e-04	5	121	2	34137443
Pubmed	Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.	KCNB2 KCNB1	1.19e-04	5	121	2	19074135
Pubmed	Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development.	LRP4 FGF4	1.19e-04	5	121	2	28694256
Pubmed	A novel family of bromodomain genes.	BAZ2B BAZ2A	1.19e-04	5	121	2	10662543
Pubmed	K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.	KCNB2 KCNB1	1.19e-04	5	121	2	2333511
Pubmed	Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.	KCNB2 KCNB1	1.19e-04	5	121	2	31663850
Pubmed	In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.	BAZ2B BAZ2A	1.78e-04	6	121	2	35090595
Pubmed	Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR.	KCNB2 KCNB1	2.49e-04	7	121	2	34312846
Pubmed	A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.	ARHGAP4 EXOC7	2.49e-04	7	121	2	21148297
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	EVPL SEC16A MACF1 ZFR CDC73 CORO7 DYNC1H1	2.76e-04	360	121	7	33111431
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	FAAP20 SMPD4 KCNB2 RABL3 SEC16A MACF1	3.28e-04	263	121	6	34702444
Pubmed	Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.	CUBN RASIP1	3.32e-04	8	121	2	25147783
Pubmed	Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.	KEL TAP1	3.32e-04	8	121	2	25798939
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP36 RABL3 WDR3 ARL10 SEC16A MIEF1 ZFR PKN1 DYNC1H1 SEC23B	3.99e-04	777	121	10	35844135
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SMG1 ATP13A4 ZNF444 PLVAP STRBP RABL3 PREPL CYFIP1 SNTB2	4.06e-04	638	121	9	31182584
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 APC2 DZIP1 PREPL WDR3 NAA25 ZNF197 LRP4 MACF1 RORB EXOC7 COG4 DYNC1H1	5.50e-04	1285	121	13	35914814
Pubmed	Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.	RASIP1 RIN1	6.47e-04	11	121	2	15031288
Pubmed	FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.	KCNB2 KCNB1	6.47e-04	11	121	2	33124732
Pubmed	Structure of a mammalian sperm cation channel complex.	TMEM249 CATSPERB	9.13e-04	13	121	2	34225353
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	ANAPC1 SEC16A MRPS34 PKN1 CORO7 SEC23B	9.47e-04	322	121	6	39098523
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	LENG9 ANAPC1 MED12L MACF1 CDC73 EXOC7 DYNC1H1 SEC23B	1.01e-03	582	121	8	20467437
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH5 DYNC1H1	1.06e-03	14	121	2	9373155
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	AKAP3 SMPD4 ANAPC1 GUSB SEC16A MIEF1 CORO7 EXOC7 COG4	1.09e-03	733	121	9	34672954
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	ZNF24 ANAPC1 TAP1	1.16e-03	59	121	3	28813667
Pubmed	Tagging genes with cassette-exchange sites.	STRBP FSTL1 DNAJC11 MACF1 CDC73 SNTB2	1.16e-03	335	121	6	15741177
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	NUP210L STRBP SMPD4 RABL3 LRFN4 SEC16A ZFR DYNC1H1 SNTB2	1.32e-03	754	121	9	35906200
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	CACNA1F WDR81 KCNB1 MACF1 RORB	1.37e-03	233	121	5	32290105
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGAP9 RABL3 PREPL ARHGAP4 ZNF24 CYFIP1 DNAJC11 SEC16A ZFR SNTB2	1.39e-03	916	121	10	32203420
Pubmed	A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias.	STYK1 TYK2	1.40e-03	16	121	2	19464057
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	RIN1 SEC16A MACF1 CDC73 DYNC1H1	1.42e-03	235	121	5	28378594
Pubmed	Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.	MACF1 DYNC1H1	1.58e-03	17	121	2	20395553
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PEX6 IDUA CCND3 TYK2 ESRP2 SEC16A LRP4 NLRC5 PKN1 BRAT1 DYNC1H1	1.68e-03	1105	121	11	35748872
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	CYFIP1 ANAPC1 DNAJC11 BRAT1	1.69e-03	145	121	4	28846114
Pubmed	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	WDR81 VKORC1L1	1.77e-03	18	121	2	24068962
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SMG1 DZIP1 PREPL FSTL1 MED12L MACF1 ADPGK	1.82e-03	497	121	7	23414517
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	USP36 BAZ2B STRBP WDR3 CYFIP1 BAZ2A SEC16A ZFR CDC73 PHIP	1.88e-03	954	121	10	36373674
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	STRBP WDR3 CYFIP1 GUSB MRPS34 MACF1 ZFR BRAT1 TAP1 ADPGK DYNC1H1 SEC23B	1.92e-03	1297	121	12	33545068
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RIN1 SEC16A PKN1 EXOC7 BRAT1 CTU1 SNTB2	1.95e-03	503	121	7	16964243
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	ZNF197 MACF1 EXOC7 DYNC1H1	1.96e-03	151	121	4	17043677
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	STRBP VPS4A MC1R CCDC80 SEC16A EXOC7 DYNC1H1 SEC23B	1.97e-03	647	121	8	26618866
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	MC1R LRP4 RORB	2.06e-03	72	121	3	25917818
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PEX6 SMPD4 RABL3 PREPL WDR3 BAZ2A DNAJC11 SEC16A MIEF1 MRPS34 ZFR PHIP SEC23B	2.16e-03	1496	121	13	32877691
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	EVPL PREPL TYK2 CYFIP1 ARL10 DNAJC11 SEC16A CDC73 CORO7 SNTB2	2.19e-03	974	121	10	28675297
Pubmed	The ULK1-FBXW5-SEC23B nexus controls autophagy.	SEC16A SEC23B	2.19e-03	20	121	2	30596474
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	DCHS2 ACD CRACR2B RABL3 FCSK FSTL1 KCNB1 ANAPC1 BRAT1	2.22e-03	814	121	9	23251661
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	BAZ2B BAZ2A PHIP	2.31e-03	75	121	3	25593309
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	CYFIP1 SEC16A BRAT1 DYNC1H1 SEC23B	2.36e-03	264	121	5	32814769
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MACF1 DYNC1H1 SEC23B	2.40e-03	76	121	3	27542412
Pubmed	NotI flanking sequences: a tool for gene discovery and verification of the human genome.	FAAP20 SNTB2	2.41e-03	21	121	2	12136098
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	DNAJC11 MACF1 TAP1 SNTB2	2.41e-03	160	121	4	31678930
Pubmed	Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.	BAZ2B BAZ2A RORB	2.49e-03	77	121	3	21525287
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	SEC16A SEC23B	2.65e-03	22	121	2	35120648
Pubmed	A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.	VPS4A SNTB2	2.65e-03	22	121	2	12417987
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	RIOX1 WDR3 CYFIP1 MRPS34 DYNC1H1	2.68e-03	272	121	5	25315684
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	USP36 VPS4A WDR3 RIN1 CYFIP1 BAZ2A SEC16A MACF1 ZFR CORO7 PHIP DYNC1H1	2.71e-03	1353	121	12	29467282
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	ERVK13-1 ANAPC1 KEL SNTB2	3.00e-03	170	121	4	23314748
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	ANAPC1 DYNC1H1	3.15e-03	24	121	2	33705438
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CYFIP1 BAZ2A ANAPC1 ICAM5 SEC16A ZFR DYNC1H1	3.16e-03	549	121	7	38280479
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	STRBP CYFIP1 MRPS34 ZFR CDC73 DNAH5 DYNC1H1 SEC23B	3.29e-03	704	121	8	29955894
Pubmed	Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.	TYK2 FGF4	3.42e-03	25	121	2	11294897
Cytoband	16q22.1	ACD VPS4A ESRP2 FCSK COG4 SNTB2	5.07e-07	110	121	6	16q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	ACD VPS4A ESRP2 FCSK COG4 SNTB2	9.71e-06	183	121	6	chr16q22
GeneFamily	EF-hand domain containing\|Plakins	EVPL MACF1	5.32e-04	8	80	2	939
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2B BAZ2A	1.04e-03	11	80	2	1025
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP CH25H CRACR2B ADAMTSL3 RASIP1 RIN1 FSTL1 KCNB1	5.44e-08	191	121	8	9fc674a58f20b47255e4457d5195c8cff17b0414
ToppCell	droplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP CH25H CRACR2B ADAMTSL3 RASIP1 RIN1 FSTL1 KCNB1	5.44e-08	191	121	8	c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLVAP APC2 CH25H ADAMTSL3 RIN1 FSTL1 KCNB1	9.67e-07	192	121	7	1990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLVAP APC2 CH25H ADAMTSL3 RIN1 FSTL1 KCNB1	9.67e-07	192	121	7	845cc9c18b4436b07dd3ce7980052683937546d2
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLVAP APC2 CH25H ADAMTSL3 RIN1 FSTL1 KCNB1	9.67e-07	192	121	7	c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Endothelial-new-cluster\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP STRBP GIMAP1 CDAN1 FCSK CTU1	7.64e-06	172	121	6	2fcc6278ead890019a6505fb4fcb518751262dda
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 GIMAP1 TPBGL CRACR2B RASIP1 KCNB1	1.27e-05	188	121	6	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ATP13A4 STYK1 CH25H CRACR2B CATSPERB DNAH5	1.27e-05	188	121	6	07705bed928683470a52c8ccfa40ffb9a0971318
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	ETV7 SLC7A11 RIN1 CYFIP1 TAP1 ADPGK	1.43e-05	192	121	6	4e689bca7a242f8482e25f273656e2caba8821c0
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 ADAMTSL3 FSTL1 NRXN2 LRP4 DNAH5	1.61e-05	196	121	6	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 ADAMTSL3 FSTL1 NRXN2 LRP4 DNAH5	1.61e-05	196	121	6	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CACNA1F ATP13A4 ABCA3 LMNTD2 ICAM5 DNAH5	1.65e-05	197	121	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CACNA1F ATP13A4 ABCA3 LMNTD2 ICAM5 PHIP	1.65e-05	197	121	6	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	STRBP ADAMTSL3 BAZ2A ZFR CDC73 PHIP	1.70e-05	198	121	6	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	STRBP ADAMTSL3 BAZ2A ZFR CDC73 PHIP	1.70e-05	198	121	6	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	STRBP ADAMTSL3 BAZ2A ZFR CDC73 PHIP	1.70e-05	198	121	6	62cbf4b29e8af4983fb47a17f96da62682a5137e
Computational	Neighborhood of TYK2	TYK2 ARHGAP4 CORO7 ADPGK	5.22e-05	33	68	4	GNF2_TYK2
Disease	Intellectual Disability	APC2 PEX6 PREPL FCSK NRXN2 MED12L MACF1 PHIP DYNC1H1	6.61e-05	447	115	9	C3714756
Disease	Congenital dyserythropoietic anemia, type I	CDAN1 SEC23B	8.99e-05	4	115	2	C0271933
Disease	Congenital dyserythropoietic anemia, type II	CDAN1 SEC23B	8.99e-05	4	115	2	C1306589
Disease	Congenital dyserythropoietic anemia, type III	CDAN1 SEC23B	1.49e-04	5	115	2	C0271934
Disease	Congenital dyserythropoietic anemia	CDAN1 SEC23B	1.49e-04	5	115	2	C0002876
Disease	obesity (implicated_via_orthology)	DCHS2 PRLHR TYK2 SEC16A MED12L CORO7	2.03e-04	215	115	6	DOID:9970 (implicated_via_orthology)
Disease	Congenital dyserythropoietic anemia	CDAN1 SEC23B	2.24e-04	6	115	2	cv:C0002876
Disease	Familial Atypical Mole Melanoma Syndrome	ACD MC1R	8.09e-04	11	115	2	C2314896
Disease	guanosine diphosphate measurement	BAZ2B KCNB2	8.09e-04	11	115	2	EFO_0010494
Disease	Myasthenic Syndromes, Congenital, Slow Channel	PREPL LRP4	1.74e-03	16	115	2	C0751885
Disease	Congenital Myasthenic Syndromes, Postsynaptic	PREPL LRP4	1.97e-03	17	115	2	C0751883
Disease	Congenital Myasthenic Syndromes, Presynaptic	PREPL LRP4	2.47e-03	19	115	2	C0751884
Disease	response to methotrexate, neurotoxicity	MACF1 PKN1	2.47e-03	19	115	2	EFO_0011057, GO_0031427
Disease	Infiltrating duct carcinoma of female breast	SMG1 PKN1	3.01e-03	21	115	2	C3165106
Disease	Malignant neoplasm of breast	ABCA3 STRBP APC2 GIMAP1 CUBN NAA25 ICAM5 NLRC5 FGF4 MACF1 CTU1	3.20e-03	1074	115	11	C0006142
Disease	myeloperoxidase (MPO)-DNA complex measurement	ATP13A4 CATSPERB	3.31e-03	22	115	2	EFO_0011039
Disease	otitis media (implicated_via_orthology)	IDUA DNAH5	3.31e-03	22	115	2	DOID:10754 (implicated_via_orthology)
Disease	schizophrenia (is_implicated_in)	SLC25A27 CYFIP1 TAP1	3.55e-03	78	115	3	DOID:5419 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRRDLPVTRTLIDWH	CAPZA3	256	Q96KX2
LWVRLSPRVACLLER	BRAT1	236	Q6PJG6
RLAAAWDALIVRPVR	ADPGK	56	Q9BRR6
TSILLVRAREGVWIP	ERVK13-1	246	Q9NX77
AVSPRQLRDWEVLVL	CCND3	131	P30281
RSEFPRRRALEDWLL	BLACE	31	A4D250
DRILWLVDIPRENIT	CATSPERB	106	Q9H7T0
LDRPVFLRFWETLDR	CDC73	506	Q6P1J9
RRLDLLCTPVLWRAS	ATP13A4	1096	Q4VNC1
LTWRLTPAEVRQVLA	COG4	756	Q9H9E3
REALRSLASLWPRVV	APOBEC4	171	Q8WW27
EITPRIRVWRQTLER	BAZ2A	1636	Q9UIF9
RRIEEDIAPGLRVWR	BAZ2B	1886	Q9UIF8
DPVARRLLWDTVARA	ABCA3	1546	Q99758
ARRAVLTVPWLVEFL	CDAN1	686	Q8IWY9
TRPREWDLLLFLLRE	CDAN1	1146	Q8IWY9
RWRRRLLVISAPNDE	CCDC80	776	Q76M96
DSERPLLVQELWRAR	RASIP1	231	Q5U651
LRRWSLEALNRDLVP	RABL3	106	Q5HYI8
VTLPRARRAVAAIWV	MC1R	156	Q01726
LIWSEDLRVQDVRRL	ANAPC1	1026	Q9H1A4
FVVDSADRLRLPWAR	ARL10	151	Q8N8L6
PLVSLLSAWIVARLR	DUOX1	606	Q9NRD9
DVSRPLVRERLWVNS	CACNA1F	1051	O60840
ILTRIRSFLDDPIWR	CYFIP1	1096	Q7L576
WEVVERRRTPAEIRE	DNAJC11	91	Q9NVH1
RILDRWSVMIRETPR	DGKK	611	Q5KSL6
LRLRWLRQTLESFIP	NSUN3	166	Q9H649
SLELLVDWVRLEARL	MAP10	11	Q9P2G4
SERRGVWLVAPLIAR	MED12L	1406	Q86YW9
RERLWAELLRTVSPE	FAAP20	36	Q6NZ36
LAAIERWEDRPRRSQ	KCNK16	151	Q96T55
AVAGEDARIRLWRVP	CORO7	561	P57737
DLRNLWRDSIIPRSL	PLVAP	236	Q9BX97
RWESLVALSLARLPV	FGF4	46	P08620
RWLARQLVDIREPET	ICAM5	81	Q9UMF0
LRTAADVIQRIRWDP	LENG9	86	Q96B70
RVQVLEPRWDLSDRL	PEX6	241	Q13608
SWLRDPDRTVVLAKR	NAT16	86	Q8N8M0
IERQVLAWARAPLSR	EVPL	541	Q92817
RIPYRLGRVVDEWLL	NRXN2	1266	Q9P2S2
EVSRALLELVPWRAR	MACF1	1751	O94854
LESLDPRTLRLLWRQ	LMNTD2	56	Q8IXW0
PRTLRLLWRQRELEI	LMNTD2	61	Q8IXW0
LWRLSLRPAETARLR	MIEF1	336	Q9NQG6
LPESVLQDVIRISRW	EXOC7	191	Q9UPT5
VQEPWADRARVLSLL	NLRC5	1386	Q86WI3
AVAEWRLPSLRRATL	SMPD4	6	Q9NXE4
LSGVVRVWRPLDREA	DCHS2	361	Q6V1P9
RICEWRITAPEGRRI	CUBN	2476	O60494
ERDKWLSRPALLVRA	FCSK	656	Q8N0W3
WRRIRDEDVPHILRS	APC2	2146	O95996
LRWAGPEERLRRVAE	GIMAP1	231	Q8WWP7
AHEVLWRTLDRLPRT	KCNB1	41	Q14721
HEVLWRTLDRLPRTR	KCNB2	46	Q92953
RLRIQPALWSREDVL	ETV7	46	Q9Y603
LLWIREELGNLRRVD	ERICH4	51	A6NGS2
AVRRQAARWELPLTV	CTU1	101	Q7Z7A3
ILPERWTQDLRTRVV	GUSB	106	P08236
LRRRIIQWLEAEIIP	FSTL1	121	Q12841
AVRTLWARLQRERPE	CRACR2B	156	Q8N4Y2
LLAVELVRTARWELA	CYP26C1	471	Q6V0L0
LVHVDAARALWPLRR	IDUA	31	P35475
RWVRGIFEALRPLET	DYNC1H1	2801	Q14204
AWRPVARDALLARAF	KLHDC9	16	Q8NEP7
VLRRLDWSTLVPLRL	GLB1L2	26	Q8IW92
ILLDRRRPQWELSPE	SDR42E2	61	A6NKP2
LLLSRPLKERRVEWL	PIWIL3	181	Q7Z3Z3
VVLDILCSWVPALRR	CH25H	56	O95992
RLLLIRSWCPDRTIA	DNAH5	3996	Q8TE73
LPLRVAVDLWSRREL	IL17RC	611	Q8NAC3
WLIPVSRLRDTVLEL	NUP210L	786	Q5VU65
PVRAWADVRRESRLL	MRPS34	51	P82930
LVLAVWDRSLPLRTE	SYT8	326	Q8NBV8
VSLRERLLLTRPVWL	RIN1	56	Q13671
VRVLRPALEWAVSNR	RMND5A	166	Q9H871
SFREELRKLLVAWPR	PRLHR	341	P49683
LVAELRRVTVLWDEL	SMG1	1951	Q96Q15
ADWVLLRTALPRIFS	TAP1	31	Q03518
VWVVLARRSPATREV	SLC41A1	301	Q8IVJ1
VLRILRDLCNRVPTW	STRBP	221	Q96SI9
DVATWVRLLRRLIPN	PKN1	511	Q16512
VRGRAWSLLLDIDRI	TBC1D26	106	Q86UD7
DLILLVWQVVEPRSR	ESRP2	51	Q9H6T0
RPRLESVDWRRLSAI	DZIP1	61	Q86YF9
AERVEHVSRLLWRLP	ARHGAP4	611	P98171
WDSPLRRVLAELNRI	RIOX1	181	Q9H6W3
GPDVLRWLDRQLIRL	SEC23B	541	Q15437
WVPVAALAQLLTRRR	SLC6A18	581	Q96N87
RLVLRPWIRELILGS	ACD	6	Q96AP0
TDPVRVLSWLRRDLE	AKAP3	36	O75969
WTLRRLRERADAPSV	ADGRG5	436	Q8IZF4
ERLLLRPASIRADVW	STYK1	296	Q6J9G0
LPAFVRVWVELLIIR	SLC7A11	121	Q9UPY5
RVWVELLIIRPAATA	SLC7A11	126	Q9UPY5
PREAVSQLRELCRLW	ZNF24	66	P17028
LRALCRDWLRPEVHT	ZNF444	41	Q8N0Y2
PQEALSRLRELCRRW	ZNF197	56	O14709
VIRVLRDLCRRVPTW	ZFR2	791	Q9UPR6
LVAWSRRVVVPELSA	PHIP	716	Q8WWQ0
IAELLLRDHRTVWLP	SEC16A	1556	O15027
RTDAWLPVAELRRPQ	KBTBD13	326	C9JR72
RELQELCRRWLRPEL	ZSCAN25	61	Q6NSZ9
AVLISPDRAWLIEPR	RORB	376	Q92753
EEERLLPLTQRWPRA	SLC25A27	6	O95847
RLVRWVEARREAPTG	ARHGAP9	436	Q9BRR9
RPERRVLVDDGWILA	PREPL	491	Q4J6C6
LLRVSVPRWERVARY	VKORC1L1	6	Q8N0U8
LAARDPIWAARFRSI	ZNF862	206	O60290
TLELRRAPRLWKVRA	TMEM253	81	P0C7T8
IRILRDLCQRVPTWS	ZFR	926	Q96KR1
AARPLLAWLRNATER	TPBGL	241	P0DKB5
DKSLRLWERTREPLI	WDR3	696	Q9UNX4
GLVELLLRERWVRVV	SNTB2	26	Q13425
LLRERWVRVVAELSG	SNTB2	31	Q13425
ALVPARWLASLRDRR	WDR81	56	Q562E7
PTERLSLRWERVFRV	USP36	106	Q9P275
WLVISSLPRRRLVLN	TMEM249	101	Q2WGJ8
ALSREERVERIPWLA	TYK2	766	P29597
TNIPWVLDSAIRRRF	VPS4A	271	Q9UN37
VLHLLERRWPESRIV	ADAMTSL3	1381	P82987
PWAVARRVLTAILIL	KEL	41	P23276
TVLIWENLDRPRDIV	LRP4	851	O75096
ELLWLRRLARPDDLE	LRFN4	241	Q6PJG9
EEETLWLRIRSLTLR	NAA25	681	Q14CX7