Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR2 ITPR2

1.10e-0518493GO:0015278
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2

3.53e-054492GO:0005219
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR1 RYR2 ITPR2

5.95e-0531493GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 RYR2 ITPR2

7.19e-0533493GO:0005217
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2

8.79e-056492GO:0048763
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

TMEM63B RYR1 RYR2 ITPR2

3.84e-04140494GO:0099094
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

TMEM63B RYR1 RYR2 ITPR2

1.28e-03193494GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

TMEM63B RYR1 RYR2 ITPR2

1.38e-03197494GO:0022834
GeneOntologyMolecularFunctionmonoatomic cation channel activity

NALCN TMEM63B RYR1 RYR2 ITPR2

1.49e-03343495GO:0005261
GeneOntologyBiologicalProcessperipheral nervous system axon ensheathment

ARHGEF10 PLEC ITGB4

6.95e-0533503GO:0032292
GeneOntologyBiologicalProcessmyelination in peripheral nervous system

ARHGEF10 PLEC ITGB4

6.95e-0533503GO:0022011
GeneOntologyBiologicalProcesshemidesmosome assembly

PLEC ITGB4

8.59e-056502GO:0031581
GeneOntologyCellularComponentsarcoplasm

PLEC RYR1 RYR2 ITPR2

1.72e-04114514GO:0016528
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

RYR1 RYR2 ITPR2

1.81e-0445513GO:0033017
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

2.59e-0410512GO:0014701
GeneOntologyCellularComponenthemidesmosome

PLEC ITGB4

3.16e-0411512GO:0030056
GeneOntologyCellularComponentreceptor complex

PLXNC1 ITGB4 ITGB7 ABCG5 LEPR SACM1L ITPR2

4.95e-04581517GO:0043235
GeneOntologyCellularComponentintegrator complex

SAGE1 SAGE2P

1.19e-0321512GO:0032039
GeneOntologyCellularComponentsarcoplasmic reticulum

RYR1 RYR2 ITPR2

1.30e-0388513GO:0016529
GeneOntologyCellularComponenttransmembrane transporter complex

NALCN BCS1L ABCG5 RYR1 RYR2 SACM1L

1.65e-03523516GO:1902495
GeneOntologyCellularComponenttransporter complex

NALCN BCS1L ABCG5 RYR1 RYR2 SACM1L

2.13e-03550516GO:1990351
DomainRIH_assoc

RYR1 RYR2 ITPR2

3.59e-076503PF08454
DomainRIH_assoc-dom

RYR1 RYR2 ITPR2

3.59e-076503IPR013662
DomainRIH_dom

RYR1 RYR2 ITPR2

3.59e-076503IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2 ITPR2

3.59e-076503IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2 ITPR2

3.59e-076503IPR015925
Domain-

RYR1 RYR2 ITPR2

3.59e-0765031.25.10.30
DomainRYDR_ITPR

RYR1 RYR2 ITPR2

3.59e-076503PF01365
DomainIns145_P3_rec

RYR1 RYR2 ITPR2

3.59e-076503PF08709
DomainMIR

RYR1 RYR2 ITPR2

2.14e-0610503PS50919
DomainMIR

RYR1 RYR2 ITPR2

2.14e-0610503PF02815
DomainMIR

RYR1 RYR2 ITPR2

2.14e-0610503SM00472
DomainMIR_motif

RYR1 RYR2 ITPR2

2.14e-0610503IPR016093
DomainRyanrecept_TM4-6

RYR1 RYR2

2.10e-053502IPR009460
DomainRyR

RYR1 RYR2

2.10e-053502PF02026
DomainRyanodine_rcpt

RYR1 RYR2

2.10e-053502IPR003032
DomainRR_TM4-6

RYR1 RYR2

2.10e-053502PF06459
DomainRyan_recept

RYR1 RYR2

2.10e-053502IPR013333
DomainIntegrin_bsu_tail

ITGB4 ITGB7

1.46e-047502IPR012896
DomainIntegrin_B_tail

ITGB4 ITGB7

1.46e-047502SM01242
DomainIntegrin_B_tail

ITGB4 ITGB7

1.46e-047502PF07965
DomainIntegrin_beta

ITGB4 ITGB7

1.95e-048502PF00362
DomainINB

ITGB4 ITGB7

1.95e-048502SM00187
DomainIntegrin_bsu_VWA

ITGB4 ITGB7

1.95e-048502IPR002369
DomainPSI

PLXNC1 ITGB4 ITGB7

2.21e-0444503IPR016201
DomainIon_trans_dom

NALCN RYR1 RYR2 ITPR2

2.44e-04114504IPR005821
DomainIon_trans

NALCN RYR1 RYR2 ITPR2

2.44e-04114504PF00520
DomainIntegrin_bsu

ITGB4 ITGB7

2.50e-049502IPR015812
DomainIntegin_beta_N

ITGB4 ITGB7

2.50e-049502IPR033760
DomainINTEGRIN_BETA

ITGB4 ITGB7

2.50e-049502PS00243
DomainPSI_integrin

ITGB4 ITGB7

2.50e-049502PF17205
DomainPSI

PLXNC1 ITGB4 ITGB7

2.53e-0446503SM00423
DomainRho_GTPase_activation_prot

ARHGAP15 PLXNC1 SYDE2

1.69e-0388503IPR008936
DomainEF-hand_8

RYR1 RYR2

3.73e-0334502PF13833
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 RYR2 ITPR2

1.32e-0519353M47760
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

PLEC ITGB4

2.13e-049352MM15117
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 RYR2 ITPR2

3.19e-0454353M27460
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 RYR2 ITPR2

3.19e-0454353MM15202
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

PLEC ITGB4

3.25e-0411352M27372
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR1 RYR2

3.25e-0411352M47958
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR1 RYR2

4.59e-0413352M39589
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

PLEC ITGB4 SDK1

7.74e-0473353MM15126
PathwayWP_LEPTININSULIN_SIGNALING_OVERLAP

SOCS2 LEPR

7.96e-0417352M39517
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

ITGB4 ITGB7 RYR2

8.05e-0474353M39462
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

ITGB4 ITGB7 RYR2

8.05e-0474353M16376
PathwayWP_LEPTININSULIN_SIGNALING_OVERLAP

SOCS2 LEPR

1.11e-0320352MM15867
PathwayKEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM

ITGB4 ITGB7 RYR2

1.12e-0383353M8728
PathwayKEGG_DILATED_CARDIOMYOPATHY

ITGB4 ITGB7 RYR2

1.42e-0390353M835
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY

ITGB4 ITGB7

1.47e-0323352M47537
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY

ITGB4 ITGB7

1.47e-0323352M47720
PathwayREACTOME_CELL_CELL_COMMUNICATION

PLEC ITGB4 SDK1

1.71e-0396353MM14592
PathwayREACTOME_STIMULI_SENSING_CHANNELS

NALCN RYR1 RYR2

1.87e-0399353MM14910
PathwayPID_INTEGRIN_CS_PATHWAY

ITGB4 ITGB7

1.87e-0326352M47
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY

ITGB4 ITGB7

1.87e-0326352M47719
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR1 RYR2 ITPR2

1.19e-08451319120137
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 RYR2 ITPR2

5.92e-08651323463619
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 RYR2 ITPR2

5.92e-08651320519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 RYR2 ITPR2

5.92e-08651325966694
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 RYR2 ITPR2

5.92e-08651316844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 RYR2 ITPR2

1.04e-07751311860456
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 RYR2 ITPR2

1.65e-07851319033399
Pubmed

Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations.

PLEC ITGB4

2.11e-06251211328943
Pubmed

Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.

RYR2 ITPR2

2.11e-06251228158491
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

2.11e-06251217259277
Pubmed

Lack of Socs2 expression causes the high-growth phenotype in mice.

SOCS2 PLXNC1

2.11e-06251211401434
Pubmed

ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.

LEPR RYR1

2.11e-06251237468098
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

2.11e-06251214722100
Pubmed

Widespread aplasia cutis congenita in sibs with PLEC1 and ITGB4 variants.

PLEC ITGB4

2.11e-06251231184804
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

2.11e-06251226009179
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

2.11e-06251232899693
Pubmed

Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin.

PLEC ITGB4

2.11e-06251215817481
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

2.11e-06251230542613
Pubmed

Mitochondrial calcium overload is a key determinant in heart failure.

RYR2 ITPR2

2.11e-06251226217001
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

2.11e-06251215280431
Pubmed

Expression of the ryanodine receptor isoforms in immune cells.

RYR1 RYR2

2.11e-06251211673493
Pubmed

B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.

RYR1 RYR2

2.11e-06251211673462
Pubmed

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

RYR1 RYR2

2.11e-06251225370123
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

2.11e-06251215033925
Pubmed

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.

RYR1 RYR2

2.11e-06251218618700
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2

6.32e-06351218403125
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2

6.32e-06351218434746
Pubmed

Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes.

PLEC ITGB4

6.32e-06351219242489
Pubmed

Structural characterization of the mouse high growth deletion and discovery of a novel fusion transcript between suppressor of cytokine signaling-2 (Socs-2) and viral encoded semaphorin receptor (Plexin C1).

SOCS2 PLXNC1

6.32e-06351212459263
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2

6.32e-0635129204703
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2

6.32e-0635127876312
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2

6.32e-06351221881589
Pubmed

Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.

RYR1 RYR2

6.32e-06351224123915
Pubmed

Epidermolysis Bullosa with Pyloric Atresia

PLEC ITGB4

6.32e-06351220301336
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2

6.32e-06351212213830
Pubmed

Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.

RYR1 RYR2

6.32e-06351223278119
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2

6.32e-0635129242641
Pubmed

Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin.

PLEC ITGB4

6.32e-06351219419971
Pubmed

A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region.

SOCS2 PLXNC1

6.32e-0635129806843
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2

6.32e-06351222948152
Pubmed

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

RYR1 RYR2

6.32e-06351223454728
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2

6.32e-06351210788707
Pubmed

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

RYR1 ITPR2

6.32e-06351223223241
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR2

6.32e-06351225239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR2

6.32e-0635127621815
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR1 RYR2

6.32e-06351218643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR1 RYR2

6.32e-06351211159936
Pubmed

Intracellular calcium release channel expression during embryogenesis.

RYR1 RYR2

6.32e-0635129986730
Pubmed

A Leptin-Mediated Neural Mechanism Linking Breathing to Metabolism.

NALCN LEPR

6.32e-06351233176139
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR2

6.32e-06351210473538
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR1 RYR2

6.32e-0635127959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR1 RYR2

6.32e-0635124600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR1 RYR2

6.32e-0635127635066
Pubmed

Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver.

ABCG5 LEPR

1.26e-05451217561514
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR1 RYR2

1.26e-05451218206662
Pubmed

Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.

RYR1 RYR2

1.26e-05451222504960
Pubmed

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.

RYR1 RYR2

1.26e-05451223992453
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR1 RYR2

1.26e-05451223413940
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR1 RYR2

1.26e-0545129384575
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR1 RYR2

1.26e-0545129607712
Pubmed

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

PLEC ITGB4

1.26e-05451214668477
Pubmed

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.

RYR1 RYR2

1.26e-05451227226555
Pubmed

FKBP binding characteristics of cardiac microsomes from diverse vertebrates.

RYR1 RYR2

1.26e-05451211237759
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR1 RYR2

1.26e-05451223482488
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

ITGB4 ITGB7 LEPR ITPR2

1.51e-0510151423382219
Pubmed

Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.

RYR1 RYR2

2.10e-05551222939628
Pubmed

Intracellular calcium-release channels: regulators of cell life and death.

RYR1 RYR2

2.10e-0555129124414
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR1 RYR2

2.10e-05551223918386
Pubmed

Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes.

PLEC ITGB4

2.10e-05551225703379
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR1 RYR2

2.10e-05551219011160
Pubmed

CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis.

ARHGAP15 SCYL1

2.10e-05551215459234
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

RYR1 RYR2 ITPR2

2.42e-053851330786075
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR1 RYR2

3.15e-05651219549818
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR1 RYR2

3.15e-05651226025922
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR1 RYR2

3.15e-05651214592808
Pubmed

Junctional Epidermolysis Bullosa

PLEC ITGB4

3.15e-05651220301304
Pubmed

A complex interaction pattern of CIS and SOCS2 with the leptin receptor.

SOCS2 LEPR

3.15e-05651216684815
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR1 RYR2

3.15e-05651219009018
Pubmed

The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.

PLEC ITGB4

4.41e-05751210637308
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR1 RYR2

4.41e-05751220962236
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

LEPR ITPR2

4.41e-05751222495310
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR1 RYR2

5.87e-05851211784029
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

PLEC ITGB4

7.54e-05951212482924
Pubmed

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.

RYR1 RYR2

9.42e-051051218434328
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

PLEC ITGB4

1.15e-041151212802069
Pubmed

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.

PLEC ITGB4

1.15e-041151210811835
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

PLEC ITGB4

1.15e-041151216757171
Pubmed

Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids.

ITGB4 ITGB7

1.38e-041251210090148
Pubmed

p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.

PLEC ITGB4

1.38e-041251228595999
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

RYR1 RYR2

1.38e-041251219095005
Pubmed

Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.

PLEC ITGB4

1.63e-041351222962592
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

PLEC ITGB4

1.63e-04135129670011
Pubmed

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.

SCYL1 SACM1L MYBL2

1.65e-047251319723774
Pubmed

MED12 regulates a transcriptional network of calcium-handling genes in the heart.

RYR1 RYR2

1.90e-041451228724790
Pubmed

Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

CEP135 ASPM

2.50e-041651220301772
Pubmed

Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.

ASPM MYBL2

2.50e-041651232469866
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

PLEC BCS1L SDK1 RYR1

2.78e-0421451422199357
Pubmed

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

RYR2 ITPR2

2.83e-041751227725084
Pubmed

Hemidesmosome integrity protects the colon against colitis and colorectal cancer.

PLEC ITGB4

3.18e-041851227371534
Pubmed

Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.

PLEC LEPR

3.55e-041951232888949
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2

1.03e-053342287
GeneFamilyCD molecules|Integrin beta subunits

ITGB4 ITGB7

1.23e-0493421159
GeneFamilyImmunoglobulin like domain containing

BTLA SDK1 LEPR

5.62e-03193343594
GeneFamilyADAM metallopeptidase domain containing|CD molecules

PLXNC1 BTLA ITGB4 LEPR

6.14e-03394344471
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 PLXNC1 ASPM BTLA MYBL2

1.50e-061745057b318796728001c17b4043d2b033330c7be40c78
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical|TCGA-Thryoid / Sample_Type by Project: Shred V9

PLXNC1 MAMLD1 TMEM63B ITGB4 RYR1

2.56e-06194505b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC9A2 XRCC2 ITGB7 ASAH2B

1.75e-05138504cd2f4682fcfd0275ce0640150bbb18da839e5c0a
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ARHGEF10 SYDE2 ITGB7 ITPR2

2.43e-0515050470ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

VPS13D NALCN PLEC RYR1

3.20e-05161504347edb0de10850b7d16c40945751033289289c9b
ToppCellPSB-critical-LOC-Lymphoid-PC|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGAP15 ASPM ITGB7 MYBL2

3.44e-051645043e672124dea2497c5bdf8a315c8cfacfab5780dc
ToppCellfacs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGAP15 BTLA ITGB7 RYR1

3.44e-051645045ca7b69684a8bb12dd0b45e7ad94e30d16ed01ce
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF10 PLXNC1 BTLA ITGB7

3.52e-05165504479962ce1c3d6636ae62b6709635299748653801
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSER1 BTLA ITGB7 MYBL2

3.52e-05165504ba68090d79e2243af2bdee0c27a32e65f540f8ac
ToppCelldroplet-Bladder-nan-3m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7 RYR1

3.61e-05166504e01c720de6d4ca144c55378e023e718a64bf32f6
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC9A2 MUC16 ADAMTS13 SDK1

3.78e-05168504de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BTLA ITGB7 RYR1 MYBL2

3.78e-05168504d6078e3a79d315d6090906e171a7d67a9206b2c7
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

GPATCH1 ASPM ADAMTS13 XRCC2

3.87e-0516950402fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 PLXNC1 ASPM MYBL2

3.87e-0516950454b13ab02b4c187f4754045ecfcf409749e7ccc0
ToppCell367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

ZNF695 ASPM XRCC2 MYBL2

4.14e-051725048d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 PLXNC1 XRCC2 MYBL2

4.14e-05172504ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOCS2 PLXNC1 SPG11 ADAMTS13

4.43e-0517550491cb819a1786020713b7e64480de0545380daae9
ToppCelldroplet-Tongue-nan-3m-Myeloid|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 PLXNC1 BTLA ITGB7

4.63e-05177504b6c0ab701d9db3f19605b4d23f7e40adca3324e1
ToppCelldroplet-Tongue-nan-3m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 PLXNC1 BTLA ITGB7

4.63e-0517750434bd46704827c9db7053bbd0c671dd0b661b79b4
ToppCelldroplet-Tongue-nan-3m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 PLXNC1 BTLA ITGB7

4.63e-051775048f4b2f21091d981c12000489054198127098f62c
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7 RYR1

4.73e-051785045a4f97d19265577cfdb3e53f9dc3a9a02cfcffa9
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7 RYR1

4.94e-0518050483f9060dcf1d0ff8d2b2edc1841b2624b81c0eb3
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ELMOD2 ASPM BTLA RYR2

4.94e-051805048e96f8646c002768b272359af485dc0ab57e0ccd
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 SLC9A2 PTPN21 ITPR2

5.05e-0518150440df0afcb6848202da54670e84f22d7c3a515d01
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 SLC9A2 PTPN21 ITPR2

5.05e-051815042b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 SLC9A2 PTPN21 ITPR2

5.05e-051815046aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 SLC9A2 PTPN21 ITPR2

5.05e-0518150440d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7 RYR1

5.16e-05182504cf32603ad9b9882b0bb873327d58b50dd26a5bd3
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7 RYR1

5.16e-0518250471cfd0b6d464e3e1b1cca34f423abdf699cda48a
ToppCellfacs-Aorta-Heart-3m-Myeloid-macrophage|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7 RYR1

5.16e-05182504df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCellCV-Severe-3|CV / Virus stimulation, Condition and Cluster

SOCS2 ASPM XRCC2 LEPR

5.38e-051845041c9bda00bb6efd98f68781ca06655bf6c4282f27
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 NALCN SDK1 RYR2

5.38e-05184504d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellPBMC-Mild-cDC_12|Mild / Compartment, Disease Groups and Clusters

NALCN ASPM XRCC2 MYBL2

5.97e-05189504946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPM ITGB4 RYR1 MYBL2

6.22e-051915040f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPM XRCC2 ITGB7 MYBL2

6.35e-05192504b9c606547c303a099a653169923a44c20816a604
ToppCellTracheal-10x5prime-Immune_Lymphocytic-T-T_CD4-T_reg|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP15 ASPM BTLA ITGB7

6.88e-05196504c0028307cf5dddfc4b5db1445fa83b74019a20bd
ToppCellLung_Parenchyma-Control-Lymphocyte-B-Plasmablast-Plasmablast-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ASPM BTLA ITGB7 MYBL2

7.01e-051975040d38d126b1e653398426255e95449f1150eac1b0
ToppCellParenchyma_Control_(B.)-Immune-TX-Plasma_cells|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ASPM BTLA ITGB7 MYBL2

7.01e-051975047ffb373d5b72c67e4816f14ea9a7a2024dc7a93a
ToppCellLung_Parenchyma-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ASPM BTLA ITGB7 MYBL2

7.01e-051975042e76e9ebd8702bfeefd396cbf5114eee0f24c19b
ToppCellLung_Parenchyma-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ASPM BTLA ITGB7 MYBL2

7.01e-05197504207fce47e547fafbaf64a22efe3488e74bf19bed
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOCS2 ASPM XRCC2 MYBL2

7.15e-051985047225a6194c52b01c581e58d3cda107c4af96dc4f
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ASPM XRCC2 ITGB4 MYBL2

7.29e-05199504f0c289523957258d16135c04679db379d43d28d9
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MAMLD1 PLEC ITGB4 ITPR2

7.44e-052005047eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells-Neuroepithelial_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

CEP135 ASPM XRCC2 MYBL2

7.44e-052005040d9b8d51a7630e70e60c76c763ff82df4c559152
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells|2m / Sample Type, Dataset, Time_group, and Cell type.

CEP135 ASPM XRCC2 MYBL2

7.44e-052005040675f580ccef705875854247bbfd4ee2bcf126a1
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARHGAP15 ASPM XRCC2 MYBL2

7.44e-05200504dd5b753bb1333fa502b9d3a6d65a53a9882b2451
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Chodl_(MGE-derived_cortical_interneurons--Long-range-projecting_interneurons)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PCDHGA4 BTLA ABCG5

9.99e-0580503f102890f86fffb30d180a2450b71581181c803cf
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Chodl_(MGE-derived_cortical_interneurons--Long-range-projecting_interneurons)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PCDHGA4 BTLA ABCG5

9.99e-05805031f022bd04de842ec7193e98acae0df17913f4749
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PCDHGA4 BTLA ABCG5

1.99e-04101503cf52c93f523c5f25bd45519a1444ce7bd1d8b577
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 ADAMTS13 SDK1

2.43e-041085039c7f3e25facfb54ef0be45044999bc36438bbea0
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 ADAMTS13 SDK1

2.43e-0410850375d635fc5bb004418db2e1328c24d96b718f10b1
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C12orf56 GPATCH1 KIAA1328

3.07e-04117503240cd636d1f5d3f270825ace02126fae993f5802
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Rassf10|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ARHGEF10 ITGB7 ITPR2

3.23e-04119503ec3af1253f03b3ec403f73243237acf08ad56789
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FSIP2 KIAA1328 LEPR

3.23e-041195038eefcf1ace62ad1c90fa5b62ec159c83ec527bf3
ToppCellCOVID-19-kidney-Epithelial_Doublet|kidney / Disease (COVID-19 only), tissue and cell type

ARHGAP15 RYR1 RYR2

3.64e-04124503d6f59ddb9b9df02b5201f23fa5fb78f3fd891ee9
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARHGAP15 XRCC2 MYBL2

4.00e-041285039ab55a0421cd970e0b8dabce67dd68e382a6bd41
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARHGEF10 MAMLD1 MUC16

4.77e-0413650327a41463e6f16deb5b1d4f17fefded9959038c07
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGEF10 MAMLD1 MUC16

4.77e-0413650388b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

MUC16 OR4C12 RYR1

5.09e-0413950364c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCelldroplet-Heart-nan-3m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA ITGB7 RYR1

5.19e-04140503ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCellfacs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPG11 C1orf74 EPG5

5.41e-041425030a87c0d74e281da5dc4f59e09a5e99c62b1ea801
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|368C / Donor, Lineage, Cell class and subclass (all cells)

KIAA1328 ASPM BTLA

6.10e-0414850380470353e12599440f711b6e107730763376d04d
ToppCellClub_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

C12orf56 ADAMTS13 SDK1

6.22e-0414950381c813588bb5efb7b31141a75d387210dcb76094
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7

6.22e-0414950348fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KIAA1328 LEPR ITPR2

6.35e-041505036c39e73a0b05d4b26589f333ce13924e3d373b8d
ToppCellHealthy_donor-RBC|World / disease group, cell group and cell class (v2)

C1orf74 ADAMTS13 ASAH2B

6.35e-041505031e1a497ec4b048f7e9cc12dd5dd9aba7fedca9e1
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGEF10 RYR2 MYBL2

6.47e-0415150332d35906f4b2bd46b173e87f2dec972eb5da87b3
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 BTLA ITGB7

6.60e-041525037e686721b95c837f2b0d5116927c8ecacef055ee
ToppCellDividing_Macrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

ASPM XRCC2 MYBL2

6.60e-04152503e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCellPBMC-Control-cDC_2|Control / Compartment, Disease Groups and Clusters

MAMLD1 MUC16 SDK1

6.72e-041535034ee37266b0054f276c7a73ab9220f681b9d74c71
ToppCellHealthy_donor-RBC|Healthy_donor / disease group, cell group and cell class (v2)

C1orf74 ADAMTS13 ASAH2B

6.85e-04154503e080d5104fe6f3f6ef617bbcdccf1332ab7231e1
ToppCell368C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FSIP2 PLXNC1 LEPR

7.11e-041565034877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCelldroplet-Heart-4Chambers-21m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA ITGB7 RYR1

7.11e-041565035d97755db872d51522f6412a93704f3c79a084cd
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNC1 ITGB7 RYR1

7.11e-041565032ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

ARHGAP15 MUC16 SDK1

7.11e-0415650310d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell368C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FSIP2 PLXNC1 LEPR

7.11e-041565031d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCellfacs-Brain_Myeloid-Cerebellum|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 PLEC ITGB7

7.11e-0415650328c4fb4d2c6c47696c3a6722998f9da5a8923323
ToppCell390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

ASPM XRCC2 MYBL2

7.51e-041595030fbfdb18b7ed4bde077add13f2b3636e144b254f
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-lymphocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 ITGB7 RYR1

7.51e-041595033bab00f8fb7d9232538e50f83dd0fd70ddd16819
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VPS13D ARHGAP15 ITGB7

7.65e-04160503b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ASPM ITGB7 SACM1L

7.65e-041605031a9329d8183296f36928bd9e96f10db9f04ce326
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VPS13D ARHGAP15 ITGB7

7.65e-041605039caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-lymphocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA ITGB7 RYR1

7.65e-041605035c28121916a12dbc22ef2421040bdc9148a40b78
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-CD45|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA ITGB7 RYR1

7.65e-04160503b7093678987575f2f99d648821d31b4a37075aca
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 XRCC2 RYR1

7.65e-04160503fe9970c160159b35f6599ed13c89cfb49264d554
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VPS13D ARHGAP15 ITGB7

7.65e-04160503229841be7b984a00a301cd5d88c11226a90d8a88
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-CD45|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 ITGB7 RYR1

7.65e-041605035bec867def73fa8531f8dad611679f4b44f573bd
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VPS13D ARHGAP15 ITGB7

7.65e-0416050399c9ae2041445539fada842e1af01368669bfca0
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 ITGB7 RYR1

7.65e-041605031f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP15 BTLA RYR1

7.79e-041615030e2b54a63781397f6b99eb0e201fbb820cbd7cc6
ToppCelldroplet-Heart-nan-24m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA ITGB7 RYR1

7.79e-041615037e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCellfacs-Liver-Non-hepatocytes-24m-Lymphocytic-T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC9A2 ARHGAP15 ITGB7

7.93e-0416250315d5d31a75e26bcd41919a00300c68e9f00f0002
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGAP15 SYDE2 NKTR

7.93e-0416250380317c4253bf8e897782e562f29835f181c65b98
ToppCelldroplet-Heart-nan-18m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA ITGB7 RYR1

7.93e-041625037f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

ARHGAP15 RYR1 RYR2

8.07e-0416350319c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM XRCC2 MYBL2

8.07e-041635033f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCelldroplet-Bladder-nan-3m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 ITGB7 RYR1

8.07e-041635032f32a9ab0230fdca98ffa7fd59397301d50e4f30
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ADAMTS13 ITGB4 RYR1

8.07e-04163503f21951e63188eb0c04675a8f81a0da495c26c007
ToppCelldroplet-Bladder-nan-3m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 ITGB7 RYR1

8.07e-041635036c2967dee563295febe2adabf503d095cb911ccf
ToppCell390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ASPM XRCC2 MYBL2

8.07e-04163503aa5ea367f787c1543afb7eb80a801432e1c44011
DrugTropicamide [1508-75-4]; Down 200; 14uM; MCF7; HT_HG-U133A

SOCS2 PLEC ITGB4 LEPR RYR2 ITPR2

4.12e-061945063619_DN
DrugBiotin [58-85-5]; Up 200; 16.4uM; MCF7; HT_HG-U133A

SOCS2 VPS13D ARHGEF10 ADAMTS13 ITGB4 ITPR2

4.63e-061985063289_UP
Drugmanool

SOCS2 SAGE1

4.73e-062502CID000092131
Drug2-hydroxycarbazole

RYR1 RYR2

1.42e-053502CID000093551
Drugform bis

ZFPM1 RYR1

1.42e-053502CID000006411
Drugcis-diammineplatinum(II

RYR1 RYR2

1.42e-053502CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2

1.42e-053502CID002750949
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2

1.42e-053502CID005748312
Drug8N3-cADPR

RYR1 RYR2

1.42e-053502CID000127713
Drugaminodantrolene

RYR1 RYR2

1.42e-053502CID009570289
DrugPCB74

RYR1 RYR2

2.83e-054502CID000036218
Drug148504-47-6

RYR1 RYR2

2.83e-054502CID006444275
DrugSC 38249

RYR1 RYR2

2.83e-054502CID000134834
DrugAC1L1U7A

RYR1 RYR2

2.83e-054502CID000035682
Drug2,4-xylidinothiazoline

SAGE1 RYR1 RYR2

3.88e-0530503CID000099296
DrugA 68930

RYR1 RYR2

4.71e-055502ctd:C065380
DrugTerfenadine [50679-08-8]; Down 200; 8.4uM; MCF7; HT_HG-U133A

TPR VPS13D SLC9A2 PLEC XRCC2

6.15e-051915052227_DN
DrugDecamethonium bromide [541-22-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A

ARHGEF10 PLXNC1 NKTR XRCC2 ITGB7

6.46e-051935054174_UP
Drug0317956-0000 [391210-11-0]; Up 200; 10uM; PC3; HT_HG-U133A

SLC9A2 PLXNC1 NKTR ADAMTS13 ITPR2

6.95e-051965054331_UP
DrugAminohippuric acid [61-78-9]; Down 200; 20.6uM; MCF7; HT_HG-U133A

TPR VPS13D SLC9A2 PTPN21 ITPR2

6.95e-051965055394_DN
DrugGuanethidine sulfate [60-02-6]; Up 200; 13.4uM; MCF7; HT_HG-U133A

PLXNC1 NKTR ITGB4 ITGB7 RYR2

6.95e-051965053171_UP
DrugMBED

RYR1 RYR2

7.05e-056502CID000129958
Drugchloro-m-cresol

RYR1 RYR2

7.05e-056502CID000012008
DrugAC1O528X

RYR1 RYR2

7.05e-056502CID006475857
DrugNSC114784

RYR1 RYR2

7.05e-056502CID000419425
Drugclozapine; Up 200; 10uM; MCF7; HT_HG-U133A

NKTR ADAMTS13 PLEC LEPR RYR2

7.12e-051975056988_UP
DrugBetahistine mesylate [54856-23-4]; Down 200; 17.2uM; PC3; HT_HG-U133A

TPR VPS13D SLC9A2 NKTR PTPN21

7.12e-051975056611_DN
DrugHeptaminol hydrochloride [543-15-7]; Up 200; 22uM; PC3; HT_HG-U133A

TPR ARHGEF10 CEP135 ADAMTS13 ITPR2

7.29e-051985057313_UP
DrugDimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; MCF7; HT_HG-U133A

SLC9A2 GPATCH1 MAMLD1 PLEC LEPR

7.29e-051985054791_DN
DrugOxybenzone [131-57-7]; Up 200; 17.6uM; MCF7; HT_HG-U133A

RDH8 VPS13D ARHGEF10 PLEC RYR1

7.47e-051995056469_UP
Druggenistein; Down 200; 10uM; MCF7; HT_HG-U133A

SOCS2 NKTR PLEC PTPN21 ITGB4

7.47e-051995051660_DN
Drugphosphine oxide

ZFPM1 LEPR RYR1 RYR2

8.99e-05107504CID000166931
DrugAzumoleno

RYR1 RYR2

9.86e-057502CID000056259
DrugBr2BAPTA

RYR1 RYR2

9.86e-057502CID003081001
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 RYR2

9.86e-057502CID009547999
Drugcaprolactam

SOCS2 PLEC

1.68e-049502CID000007768
DrugTrp-Trp

TPR RYR1 RYR2

1.71e-0449503CID000088656
Drug1pxl

BCS1L ITGB4 ITGB7

1.71e-0449503CID000447958
DrugASTA Z 7557

SOCS2 XRCC2 MYBL2

1.82e-0450503CID000335628
Drugmant-GTP

TPR PLEC ITGB4

1.82e-0450503CID000128647
DrugPCB 95

RYR1 RYR2

2.10e-0410502CID000038012
DiseaseEpidermolysis Bullosa Simplex With Pyloric Atresia

PLEC ITGB4

2.48e-062472C2677349
DiseaseJunctional epidermolysis bullosa with pyloric atresia

PLEC ITGB4

2.48e-062472cv:C5676875
DiseaseEPIDERMOLYSIS BULLOSA, JUNCTIONAL 5B, WITH PYLORIC ATRESIA

PLEC ITGB4

2.48e-062472226730
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2

7.44e-063472DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2

7.44e-063472DOID:8545 (implicated_via_orthology)
DiseaseEpidermolysis bullosa with pyloric atresia

PLEC ITGB4

7.44e-063472C1856934
DiseaseAplasia Cutis Congenita

PLEC ITGB4

3.71e-056472C0282160
Diseaseeating disorder, bipolar disorder

NALCN RYR2

2.23e-0414472EFO_0005203, MONDO_0004985
DiseaseAutosomal recessive primary microcephaly

CEP135 ASPM

2.57e-0415472cv:C3711387
DiseaseAstrocytosis

ITGB4 LEPR

3.33e-0417472C3887640
DiseaseGliosis

ITGB4 LEPR

3.33e-0417472C0017639
DiseaseAntibody Deficiency Syndrome

LEPR EPG5

3.33e-0417472C0003257
DiseasePrimary microcephaly

CEP135 ASPM

5.62e-0422472C0431350
DiseaseAutosomal Recessive Primary Microcephaly

CEP135 ASPM

5.62e-0422472C3711387
DiseaseImmunologic Deficiency Syndromes

LEPR EPG5

6.15e-0423472C0021051
DiseaseDyslipidemias

ABCG5 LEPR

6.70e-0424472C0242339
DiseaseDyslipoproteinemias

ABCG5 LEPR

6.70e-0424472C0598784
Diseaseplatelet crit

SLC9A2 OSER1 ZFPM1 PLEC LEPR EPG5 ITPR2

7.26e-04952477EFO_0007985
Diseasecorpus callosum central volume measurement

SLC9A2 PLEC

9.14e-0428472EFO_0010296
Diseasecognitive decline measurement

NALCN TRMO BTLA XRCC2 SDK1

1.03e-03486475EFO_0007710
Diseaseplatelet component distribution width

ARHGAP15 MAMLD1 OSER1 TRMO ZFPM1 PLEC

1.21e-03755476EFO_0007984

Protein segments in the cluster

PeptideGeneStartEntry
LHSYTSVLSRLQVES

EPG5

381

Q9HCE0
SLEHRSEDSTIYDLL

ARHGEF10

1296

O15013
SENYTSEAHQILSRS

ELMOD2

181

Q8IZ81
SNLIESHSTTLYVTD

BTLA

121

Q7Z6A9
STRTQHLSVETSYLQ

BCS1L

71

Q9Y276
THYLLTFSSSETLLR

ASAH2B

11

P0C7U1
RDLSLAVSYSRLHSS

C1orf74

151

Q96LT6
VRRSTTYSSLHASEN

ASPM

241

Q8IZT6
SYILIRDTHSLRTTA

ADAMTS13

1356

Q76LX8
ITIHEYDSITDSSRN

ITPR2

811

Q14571
LQTYSHEVSLTADSR

PCDHGA4

781

Q9Y5G9
LSTTSHERLTTYKDT

MUC16

7746

Q8WXI7
LTHLSLIDTVYSSSS

OR4C12

61

Q96R67
LSLSSLTYQRHSNRT

KIAA0100

1416

Q14667
SLELRSYDSNSLTVS

FSIP2

3901

Q5CZC0
LLYASSHSTLSSRFT

GPATCH1

556

Q9BRR8
IASSTLIHSDLTSVY

PLXNC1

366

O60486
ISTTRDILYSHLVTN

ZFPM1

356

Q8IX07
SLAESTLQLRYHRSS

LEPR

456

P48357
VLSTSSTLTRDYNSL

ITGB4

1481

P16144
STLTRDYNSLTRSEH

ITGB4

1486

P16144
LPRDYSTLTSVSSHD

ITGB4

1506

P16144
SLQHTTSRYETSLLD

KIAA1328

501

Q86T90
DSSGSLYVRTTHRLL

RDH8

271

Q9NYR8
YNSLSSTVTLEHSSL

ITGB7

386

P26010
NSTPDLSRHLYISSS

PTPN21

576

Q16825
LFSDLVHTTESLRQS

CEP135

36

Q66GS9
DSHDRYERLTSVSSS

TMEM63B

101

Q5T3F8
DTLLSSLTVRETLHY

ABCG5

136

Q9H222
AHELARVTSSYSTSE

MAMLD1

721

Q13495
DSRLTHTLNSTTHEY

SDK1

1016

Q7Z5N4
TYDLTHTLQRLSNTS

SACM1L

136

Q9NTJ5
VSVSSERYLHLSTAS

RYR1

171

P21817
DYSTSHSARLTEDVL

RYR2

1396

Q92736
RNVISRYHLDTSVSS

SYDE2

586

Q5VT97
GSYLSASTRHRVLTS

SCYL1

456

Q96KG9
DVQSSLTHSSRDSYR

NKTR

506

P30414
YRLDGHTISDLSRSS

MYBL2

371

P10244
KIQRSSSTELLSHYD

ARHGAP15

206

Q53QZ3
LIRDSSHSDYLLTIS

SOCS2

71

O14508
RSTLEDYSQSLHART

OSER1

231

Q9NX31
ESELHLYVISTTSSI

C12orf56

271

Q8IXR9
DTSIAINHTIITSYS

SPG11

1651

Q96JI7
TSEENYLTHSDTARI

TRMO

226

Q9BU70
TAVSHTTILRLSLDY

ZSWIM5

926

Q9P217
KTARHSVLSSYLTED

ZNF695

81

Q8IW36
TLSYNRHSLTADTSE

SLC9A2

616

Q9UBY0
SSRDLYATITHSVRE

SAGE1

476

Q9NXZ1
ILATSTRDLYDTATH

SAGE2P

376

A6NJ88
ISSSSEVISQHLVSY

TPR

526

P12270
LRTHYSELTTLTSQY

PLEC

1456

Q15149
SSSTHLLLTLYSLES

XRCC2

121

O43543
YLRTRSTASLTNLEH

VPS13D

2856

Q5THJ4
SLETLTQDHSNTVRY

NALCN

781

Q8IZF0