Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alkylglycerophosphoethanolamine phosphodiesterase activity	GNA11 GNAQ	1.27e-04	5	72	2	GO:0047391
Domain	KRAB	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF774 ZNF879	9.28e-06	358	72	9	PS50805
Domain	-	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	1.01e-05	679	72	12	3.30.160.60
Domain	zf-C2H2	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	1.23e-05	693	72	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	1.25e-05	694	72	12	IPR013087
Domain	zf-C2H2_6	ZNF14 ZNF266 ZNF334 ZNF732 ZNF578 ZNF619 ZNF501 ZNF879	2.75e-05	314	72	8	PF13912
Domain	ZINC_FINGER_C2H2_2	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	3.72e-05	775	72	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	3.82e-05	777	72	12	PS00028
Domain	Znf_C2H2-like	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	4.82e-05	796	72	12	IPR015880
Domain	Znf_C2H2	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	5.38e-05	805	72	12	IPR007087
Domain	ZnF_C2H2	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	5.57e-05	808	72	12	SM00355
Domain	KRAB	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF879	8.55e-05	369	72	8	SM00349
Domain	KRAB	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF879	8.72e-05	370	72	8	IPR001909
Domain	Gprotein_alpha_Q	GNA11 GNAQ	8.75e-05	4	72	2	IPR000654
Domain	KRAB	ZNF14 ZNF585A ZNF334 ZNF732 ZNF189 ZNF578 ZNF879	4.53e-04	358	72	7	PF01352
Domain	GPCR_Rhodpsn_7TM	OR6S1 GPR31 OR4D10 CCR9 OR52N5 OR4Q3 GPR183 OR52N1 OR9A2	1.05e-03	670	72	9	IPR017452
Domain	7tm_1	OR6S1 GPR31 OR4D10 CCR9 OR52N5 OR4Q3 GPR183 OR52N1 OR9A2	1.13e-03	677	72	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6S1 GPR31 OR4D10 CCR9 OR52N5 OR4Q3 GPR183 OR52N1 OR9A2	1.23e-03	685	72	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6S1 GPR31 OR4D10 CCR9 OR52N5 OR4Q3 GPR183 OR52N1 OR9A2	1.31e-03	691	72	9	PS50262
Domain	GPCR_Rhodpsn	OR6S1 GPR31 OR4D10 CCR9 OR52N5 OR4Q3 GPR183 OR52N1 OR9A2	1.32e-03	692	72	9	IPR000276
Domain	G-alpha	GNA11 GNAQ	1.70e-03	16	72	2	PF00503
Domain	GproteinA_insert	GNA11 GNAQ	1.70e-03	16	72	2	IPR011025
Domain	-	GNA11 GNAQ	1.70e-03	16	72	2	1.10.400.10
Domain	G_alpha	GNA11 GNAQ	1.70e-03	16	72	2	SM00275
Domain	Gprotein_alpha_su	GNA11 GNAQ	1.92e-03	17	72	2	IPR001019
Domain	Olfact_rcpt	OR6S1 OR4D10 OR52N5 OR4Q3 OR52N1 OR9A2	4.06e-03	393	72	6	IPR000725
Domain	ArfGap	AGAP5 AGAP6	5.56e-03	29	72	2	SM00105
Domain	ArfGap	AGAP5 AGAP6	5.56e-03	29	72	2	PF01412
Domain	ARFGAP	AGAP5 AGAP6	5.56e-03	29	72	2	PS50115
Domain	ArfGAP	AGAP5 AGAP6	5.56e-03	29	72	2	IPR001164
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	GNA11 GNAQ	1.91e-04	6	51	2	M47548
Pathway	REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION	GNA11 GNAQ	3.54e-04	8	51	2	MM15032
Pathway	REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION	GNA11 GNAQ	3.54e-04	8	51	2	M27356
Pathway	REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION	GNA11 GNAQ	3.54e-04	8	51	2	MM15100
Pathway	KEGG_MEDICUS_REFERENCE_LPA_GNAQ_11_RHOA_SIGNALING_PATHWAY	GNA11 GNAQ	4.55e-04	9	51	2	M47732
Pathway	REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION	GNA11 GNAQ	5.67e-04	10	51	2	M1825
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	GPR31 CCR9 C3 GNA11 GPR183 GNAQ	5.85e-04	289	51	6	MM15057
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	GNA11 GNAQ	6.91e-04	11	51	2	M27317
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	GNA11 GNAQ	6.91e-04	11	51	2	MM15035
Pathway	REACTOME_SIGNALING_BY_LEPTIN	SOCS3 LEPR	6.91e-04	11	51	2	M27195
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	GNA11 GNAQ	6.91e-04	11	51	2	M47637
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	GNA11 GNAQ	8.28e-04	12	51	2	M47649
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	GPR31 CCR9 C3 GNA11 GPR183 GNAQ	9.02e-04	314	51	6	M600
Pathway	PID_THROMBIN_PAR4_PATHWAY	GNA11 GNAQ	1.31e-03	15	51	2	M138
Pathway	PID_ERB_GENOMIC_PATHWAY	ZNF14 C3	1.31e-03	15	51	2	M119
Pubmed	GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.	GNA11 GNAQ	4.35e-06	2	73	2	27498141
Pubmed	The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.	GNA11 GNAQ	4.35e-06	2	73	2	28248732
Pubmed	Uveal Melanoma: GNAQ and GNA11 Mutations in a Greek Population.	GNA11 GNAQ	4.35e-06	2	73	2	28982892
Pubmed	Mutations in GNA11 in uveal melanoma.	GNA11 GNAQ	4.35e-06	2	73	2	21083380
Pubmed	Activation of Gq/11 in the mouse corpus luteum is required for parturition.	GNA11 GNAQ	4.35e-06	2	73	2	25495873
Pubmed	GNAQ and GNA11 mutations in uveal melanoma.	GNA11 GNAQ	4.35e-06	2	73	2	25304237
Pubmed	Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.	GNA11 GNAQ	4.35e-06	2	73	2	28301547
Pubmed	Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.	GNA11 GNAQ	4.35e-06	2	73	2	16847339
Pubmed	Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.	GNA11 GNAQ	4.35e-06	2	73	2	29570931
Pubmed	Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.	GNA11 GNAQ	4.35e-06	2	73	2	10818132
Pubmed	Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.	GNA11 GNAQ	4.35e-06	2	73	2	26272756
Pubmed	NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.	GNA11 GNAQ	4.35e-06	2	73	2	31461351
Pubmed	Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.	GNA11 GNAQ	4.35e-06	2	73	2	23634288
Pubmed	Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.	GNA11 GNAQ	4.35e-06	2	73	2	26368812
Pubmed	Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.	GNA11 GNAQ	4.35e-06	2	73	2	17482476
Pubmed	Molecular genetic testing of uveal melanoma from routinely processed and stained cytology specimens.	GNA11 GNAQ	4.35e-06	2	73	2	21945171
Pubmed	Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.	GNA11 GNAQ	4.35e-06	2	73	2	24141786
Pubmed	Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.	GNA11 GNAQ	4.35e-06	2	73	2	9175863
Pubmed	SOCS3 expression within leptin receptor-expressing cells regulates food intake and leptin sensitivity but does not affect weight gain in pregnant mice consuming a high-fat diet.	SOCS3 LEPR	4.35e-06	2	73	2	26828039
Pubmed	Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.	SOCS3 LEPR	4.35e-06	2	73	2	23178499
Pubmed	Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy.	SOCS3 PRMT7	4.35e-06	2	73	2	38486105
Pubmed	The ethnic profile of patients with birthmarks reveals interaction of germline and postzygotic genetics.	GNA11 GNAQ	4.35e-06	2	73	2	28083870
Pubmed	Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.	GNA11 GNAQ	4.35e-06	2	73	2	37102682
Pubmed	Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.	GNA11 GNAQ	4.35e-06	2	73	2	26843449
Pubmed	Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.	GNA11 GNAQ	4.35e-06	2	73	2	30890659
Pubmed	Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.	GNA11 GNAQ	4.35e-06	2	73	2	7492305
Pubmed	Histone deacetylase 6 regulates insulin signaling in pancreatic β cells.	HDAC6 LEPR	4.35e-06	2	73	2	33168187
Pubmed	Reduced trabecular bone mass and strength in mice overexpressing Gα11 protein in cells of the osteoblast lineage.	GNA11 GNAQ	4.35e-06	2	73	2	24308950
Pubmed	Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.	GNA11 GNAQ	4.35e-06	2	73	2	22562663
Pubmed	Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.	GNA11 GNAQ	4.35e-06	2	73	2	11826096
Pubmed	Blue nevi and variants: an update.	GNA11 GNAQ	4.35e-06	2	73	2	21366456
Pubmed	In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.	GNA11 GNAQ	4.35e-06	2	73	2	35580369
Pubmed	Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice.	GNA11 GNAQ	4.35e-06	2	73	2	9607776
Pubmed	Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity.	SOCS3 LEPR	4.35e-06	2	73	2	25161884
Pubmed	Reverse Phenotyping in Patients with Skin Capillary Malformations and Mosaic GNAQ or GNA11 Mutations Defines a Clinical Spectrum with Genotype-Phenotype Correlation.	GNA11 GNAQ	4.35e-06	2	73	2	31726051
Pubmed	Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations.	GNA11 GNAQ	4.35e-06	2	73	2	37750536
Pubmed	G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.	GNA11 GNAQ	4.35e-06	2	73	2	11438569
Pubmed	GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification.	GNA11 GNAQ	4.35e-06	2	73	2	37802294
Pubmed	Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.	GNA11 GNAQ	4.35e-06	2	73	2	26778290
Pubmed	Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.	GNA11 GNAQ	4.35e-06	2	73	2	26628681
Pubmed	SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes.	SOCS3 LEPR	4.35e-06	2	73	2	25737950
Pubmed	Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.	GNA11 GNAQ	4.35e-06	2	73	2	30936140
Pubmed	The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis.	GNA11 GNAQ	4.35e-06	2	73	2	17552882
Pubmed	Fatness rather than leptin sensitivity determines the timing of puberty in female mice.	SOCS3 LEPR	4.35e-06	2	73	2	26762764
Pubmed	Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.	GNA11 GNAQ	4.35e-06	2	73	2	23778528
Pubmed	High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.	GNA11 GNAQ	4.35e-06	2	73	2	22977135
Pubmed	An experimental strategy to probe Gq contribution to signal transduction in living cells.	GNA11 GNAQ	4.35e-06	2	73	2	33639168
Pubmed	GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.	GNA11 GNAQ	4.35e-06	2	73	2	32064597
Pubmed	Mutational analysis of GNAQ and GNA11 to aid therapy management of a choroidal melanoma metastatic to the contralateral orbit.	GNA11 GNAQ	4.35e-06	2	73	2	23572068
Pubmed	Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations.	GNA11 GNAQ	4.35e-06	2	73	2	31173078
Pubmed	Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.	GNA11 GNAQ	4.35e-06	2	73	2	25695059
Pubmed	Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women.	SOCS3 LEPR	4.35e-06	2	73	2	16920065
Pubmed	Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.	GNA11 GNAQ	4.35e-06	2	73	2	29209985
Pubmed	Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.	GNA11 GNAQ	4.35e-06	2	73	2	12351712
Pubmed	Cardiac remodeling in Gαq and Gα11 knockout mice.	GNA11 GNAQ	4.35e-06	2	73	2	26476043
Pubmed	The activation of leptin-mediated survivin is limited by the inducible suppressor SOCS-3 in MCF-7 cells.	SOCS3 LEPR	4.35e-06	2	73	2	21239736
Pubmed	Training, leptin receptors and SOCS3 in human muscle.	SOCS3 LEPR	4.35e-06	2	73	2	21547863
Pubmed	Early-onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11.	GNA11 GNAQ	4.35e-06	2	73	2	36440997
Pubmed	Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice.	GNA11 GNAQ	4.35e-06	2	73	2	15713647
Pubmed	Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.	GNA11 GNAQ	4.35e-06	2	73	2	15175381
Pubmed	GNAQ and GNA11 mutations in melanocytomas of the central nervous system.	GNA11 GNAQ	4.35e-06	2	73	2	22307269
Pubmed	Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.	GNA11 GNAQ	4.35e-06	2	73	2	25280020
Pubmed	Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.	GNA11 GNAQ	1.30e-05	3	73	2	28700778
Pubmed	Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1.	GNA11 GNAQ	1.30e-05	3	73	2	33003441
Pubmed	P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.	GNA11 GNAQ	1.30e-05	3	73	2	26168216
Pubmed	SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.	SOCS3 LEPR	1.30e-05	3	73	2	11018044
Pubmed	The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.	GNA11 GNAQ	1.30e-05	3	73	2	10446129
Pubmed	Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice.	SOCS3 LEPR	1.30e-05	3	73	2	27471877
Pubmed	Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.	GNA11 GNAQ	1.30e-05	3	73	2	8836152
Pubmed	Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.	GNA11 GNAQ	1.30e-05	3	73	2	33166186
Pubmed	Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.	GNA11 GNAQ	1.30e-05	3	73	2	11689889
Pubmed	Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.	GNA11 GNAQ	1.30e-05	3	73	2	20372981
Pubmed	Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension.	GNA11 GNAQ	1.30e-05	3	73	2	25595485
Pubmed	The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.	GNA11 GNAQ	1.30e-05	3	73	2	32576659
Pubmed	Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.	GNA11 GNAQ	1.30e-05	3	73	2	17694176
Pubmed	Identification of HRAS mutations and absence of GNAQ or GNA11 mutations in deep penetrating nevi.	GNA11 GNAQ	1.30e-05	3	73	2	23599145
Pubmed	Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity.	SOCS3 LEPR	1.30e-05	3	73	2	18941624
Pubmed	Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice.	GNA11 GNAQ	1.30e-05	3	73	2	15340067
Pubmed	Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.	GNA11 GNAQ	1.30e-05	3	73	2	15872115
Pubmed	GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.	GNA11 GNAQ	1.30e-05	3	73	2	22758774
Pubmed	Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.	GNA11 GNAQ	1.30e-05	3	73	2	21464134
Pubmed	G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.	GNA11 GNAQ	1.30e-05	3	73	2	2123549
Pubmed	CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.	GNA11 GNAQ	1.30e-05	3	73	2	30552676
Pubmed	Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations.	GNA11 GNAQ	1.30e-05	3	73	2	31580399
Pubmed	G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone.	GNA11 GNAQ	1.30e-05	3	73	2	21345793
Pubmed	Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice.	GNA11 GNAQ	1.30e-05	3	73	2	10629036
Pubmed	Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.	GNA11 GNAQ	1.30e-05	3	73	2	16988000
Pubmed	The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signaling.	MAP1S SOCS3	1.30e-05	3	73	2	19027008
Pubmed	Acylation stimulating protein (ASP) acute effects on postprandial lipemia and food intake in rodents.	C3 LEPR	1.30e-05	3	73	2	11360154
Pubmed	Prognostic impact of chromosomal aberrations and GNAQ, GNA11 and BAP1 mutations in uveal melanoma.	GNA11 GNAQ	1.30e-05	3	73	2	28444874
Pubmed	Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).	GNA11 GNAQ	1.30e-05	3	73	2	9481484
Pubmed	High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms.	GNA11 GNAQ	1.30e-05	3	73	2	31189994
Pubmed	Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling.	GNA11 GNAQ	1.30e-05	3	73	2	12670961
Pubmed	GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers.	GNA11 GNAQ	1.30e-05	3	73	2	30204251
Pubmed	Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.	SOCS3 LEPR	1.30e-05	3	73	2	15181014
Pubmed	SOCS3 Ablation in Leptin Receptor-Expressing Cells Causes Autonomic and Cardiac Dysfunctions in Middle-Aged Mice despite Improving Energy and Glucose Metabolism.	SOCS3 LEPR	1.30e-05	3	73	2	35742928
Pubmed	Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.	GNA11 GNAQ	1.30e-05	3	73	2	30783010
Pubmed	Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.	GNA11 GNAQ	1.30e-05	3	73	2	31091422
Pubmed	G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.	GNA11 GNAQ	1.30e-05	3	73	2	26595811
Pubmed	The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway.	GNA11 GNAQ	1.30e-05	3	73	2	18991294
Cytoband	19p13.11	ZNF14 MAP1S DDA1	2.21e-04	73	73	3	19p13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	CELF5 ZNF14 ZNF266 MAP1S DDA1 C3 GNA11	2.79e-04	797	73	7	chr19p13
Cytoband	13q32.3	DOCK9 GPR183	6.17e-04	23	73	2	13q32.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	POC1A CCR9 CLEC3B ZNF501	1.65e-03	316	73	4	chr3p21
Cytoband	10q22.2	AGAP5 CTNNA3	1.96e-03	41	73	2	10q22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr15q21	TMOD3 SPG11 WDR72	2.87e-03	177	73	3	chr15q21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF14 ZNF585A ZNF266 ZNF334 ZNF732 ZNF189 ZNF578 ZNF619 ZNF623 ZNF501 ZNF774 ZNF879	2.83e-06	718	59	12	28
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP6	1.38e-03	17	59	2	1291
ToppCell	metastatic_Brain-Fibroblasts-Undetermined\|Fibroblasts / Location, Cell class and cell subclass	AGAP5 ZNF585A UNC5C SPG11 CNOT1 ZNF774	3.94e-07	172	73	6	c3822ff7329c3ac38c68c5c38cd67c390682e2a6
ToppCell	LV\|World / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2 TMEM71	1.17e-05	180	73	5	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2 TMEM71	1.44e-05	188	73	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	T_cells-Central_memory_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MAST4 DOCK9 SOCS3 GPR183 GNAQ	1.56e-05	191	73	5	25dd538d6a361bd3367c8a1c0dfc9e7003061af3
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2 TMEM71	1.59e-05	192	73	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	DOCK9 GNAQ PARP14 LEPR CEMIP2	1.63e-05	193	73	5	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	FBXO40 MAST4 CTNNA3 PKP2 TMEM71	1.72e-05	195	73	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SOCS3 CLEC3B LEPR CEMIP2	1.72e-05	195	73	5	667a2ed4b865e9a37674b3d154bb5bf2188b3ebf
ToppCell	ASK452-Endothelial-Endothelium\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	DOCK9 SOCS3 CLEC3B LEPR CEMIP2	1.85e-05	198	73	5	e282769f5fa1765bcce79a0ed9d761bf2e14b012
ToppCell	ASK452-Endothelial\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	DOCK9 SOCS3 CLEC3B LEPR CEMIP2	1.89e-05	199	73	5	0bc97a9a78aaafd1554ae6a61356ed9ea4983fa5
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SOCS3 CLEC3B LEPR CEMIP2	1.89e-05	199	73	5	8db1acdcabf97f01b9ca17456c48ec8ac4928390
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial-Endothelial\|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MAST4 SOCS3 CLEC3B LEPR CEMIP2	1.94e-05	200	73	5	2ae62c428728c1d9d4471d4be24bd6ab074fa22c
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	MAST4 DOCK9 RNF213 PARP14 LEPR	1.94e-05	200	73	5	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MAST4 DOCK9 RNF213 PARP14 CEMIP2	1.94e-05	200	73	5	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	MAST4 DOCK9 RNF213 PARP14 CEMIP2	1.94e-05	200	73	5	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	distal-2-Endothelial-Capillary\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK9 SOCS3 CLEC3B LEPR CEMIP2	1.94e-05	200	73	5	8daf09d63c2fda6da6e5b66f96e7449ee8b17029
ToppCell	distal-Endothelial-Capillary\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK9 SOCS3 CLEC3B LEPR CEMIP2	1.94e-05	200	73	5	0ee29b2bd9cd3a1c80e0535017814f752c3eb1fa
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MAST4 DOCK9 RNF213 PARP14 LEPR	1.94e-05	200	73	5	3585484c7e24e941708bee471ca607d8ccee74e6
ToppCell	distal-Endothelial-Capillary-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK9 SOCS3 CLEC3B LEPR CEMIP2	1.94e-05	200	73	5	ab96d3d801373459a2503ccfb665dc3f43bfb5a1
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR9 DENND2D GPR183 TMEM71	1.45e-04	162	73	4	b877b232f0a879a9058d81ad4730e7846484b7c3
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR9 DENND2D GPR183 TMEM71	1.45e-04	162	73	4	7384a4dd38ed68ca02a72df6deff4d34c9694ce1
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POC1A CCR9 RAD54B KIF20B	1.52e-04	164	73	4	5621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCell	Control-Epithelial_alveolar-Mes-like\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDA1 ZNF189 PRMT7 ZNF623	1.67e-04	168	73	4	3c2ce9cfaca8ceab9b29f918ab46afc69eba3330
ToppCell	Control-Epithelial_alveolar-Mes-like-AT1_Progenitor\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDA1 ZNF189 PRMT7 ZNF623	1.67e-04	168	73	4	49180994311b3f4f9ec338b1d35d8edd7422e3c9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POC1A SLC12A3 ZNF732 RAD54B	1.71e-04	169	73	4	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBXO40 CTNNA3 PKP2 TMEM71	1.75e-04	170	73	4	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR9 DENND2D TMEM71 KIF20B	1.75e-04	170	73	4	3ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell	NS-critical-d_0-4-Epithelial-FOXN4+\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HDAC6 ADCK2 GNA11 OCRL	1.83e-04	172	73	4	a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLEKHG4B SLC12A3 GPR31 PPEF2	1.91e-04	174	73	4	991f7eab69ea3ee1045a4e44ce60a96db13df6d1
ToppCell	10x5'-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	PLEKHG4B SLC12A3 GPR31 GPR183	1.95e-04	175	73	4	1c48eec300d5a6d4a810947b995af3b8c0a5a601
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POC1A CCR9 RAD54B KIF20B	1.95e-04	175	73	4	8958c5c30437d20a4abd70d7527990f7e2a68b93
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC9C1 CTNNA3 PKP2 TMEM71	2.00e-04	176	73	4	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DENND2D GPR183 ZNF623 KIF20B	2.00e-04	176	73	4	91ad2c34144f72283ca112fd3b3784f2f6259f65
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17\|GI_large-bowel / Manually curated celltypes from each tissue	UNC5C GPR183 ADAM32 FOXA1	2.13e-04	179	73	4	6359f30005b17dc5b5c4c8f3a6a38c87ccfe4ee9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POC1A ZNF732 RAD54B KIF20B	2.17e-04	180	73	4	401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBXO40 CTNNA3 PKP2 TMEM71	2.22e-04	181	73	4	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POC1A CCR9 RAD54B KIF20B	2.27e-04	182	73	4	3948422707d6d5e021bcd7158e2eb69143613f62
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	SLC9C1 MAST4 CTNNA3 PKP2	2.27e-04	182	73	4	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POC1A CCR9 RAD54B KIF20B	2.27e-04	182	73	4	fe46819c153a81911864473badc794f243705f98
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC-tDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SLC12A3 CTNNA3 GPR183 GNAQ	2.27e-04	182	73	4	ad5c99ec62cdab347d3a03c971d981e3b924020c
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF585A POC1A ZNF619 KIF20B	2.32e-04	183	73	4	a716b446c2bf5aa294b8f580aa845098fae76354
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	MAST4 CTNNA3 PKP2 TMEM71	2.36e-04	184	73	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBXO40 CTNNA3 PKP2 TMEM71	2.36e-04	184	73	4	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBXO40 CTNNA3 PKP2 TMEM71	2.41e-04	185	73	4	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	MAST4 CTNNA3 PKP2 TMEM71	2.41e-04	185	73	4	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC9C1 MAST4 DOCK9 C3	2.46e-04	186	73	4	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	MAST4 DOCK9 GNAQ PARP14	2.51e-04	187	73	4	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	3'_v3-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	PLEKHG4B SLC12A3 CTNNA3 GPR183	2.57e-04	188	73	4	239a2162a21d3339da7c1884ab76286346fbf97f
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2	2.62e-04	189	73	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	KLHL29 MAST4 C3 WDR72	2.62e-04	189	73	4	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2	2.67e-04	190	73	4	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBXO40 CTNNA3 PKP2 TMEM71	2.67e-04	190	73	4	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2	2.67e-04	190	73	4	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2	2.72e-04	191	73	4	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	Monocytes-Tissue-resident_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	PKP2 ADCK2 C3 GPR183	2.83e-04	193	73	4	198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	MAST4 CTNNA3 PKP2 TMEM71	2.83e-04	193	73	4	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 CLEC3B GNAQ LEPR	2.83e-04	193	73	4	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 CLEC3B GNAQ LEPR	2.83e-04	193	73	4	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK9 SOCS3 LEPR CEMIP2	2.83e-04	193	73	4	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	T_cells-Central_memory_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DOCK9 SOCS3 GPR183 TMEM71	2.83e-04	193	73	4	725326d7e3604736b607c19f4069c81cb4f2d20c
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	DOCK9 PARP14 LEPR CEMIP2	2.83e-04	193	73	4	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-Activated_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCR9 DENND2D GPR183 TMEM71	2.89e-04	194	73	4	6385cf2a1529d2e225e407c33da959fccaaca3a4
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	FBXO40 MAST4 CTNNA3 PKP2	2.89e-04	194	73	4	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	FBXO40 CTNNA3 PKP2 TMEM71	2.95e-04	195	73	4	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	POC1A ZNF732 RAD54B KIF20B	2.95e-04	195	73	4	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	SLC9C1 DOCK9 GNAQ PARP14	2.95e-04	195	73	4	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	POC1A ZNF732 RAD54B KIF20B	2.95e-04	195	73	4	56d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell	(1)_T_CD8_activated\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	RNF213 DENND2D GNAQ CEMIP2	2.95e-04	195	73	4	2253590339b87692d350f9ea3d2aa851179967e1
ToppCell	ASK454-Endothelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SOCS3 CLEC3B LEPR CEMIP2	3.01e-04	196	73	4	14dd6956ef420b660be0baf52a66960e57d75d16
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	POC1A ZNF732 RAD54B KIF20B	3.01e-04	196	73	4	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	ASK454-Endothelial-Endothelium\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SOCS3 CLEC3B LEPR CEMIP2	3.01e-04	196	73	4	2b777a2026b56839112fd179f2db482c49f4594a
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MAST4 DOCK9 CLEC3B LEPR	3.06e-04	197	73	4	ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SOCS3 GPR183 PARP14 CEMIP2	3.06e-04	197	73	4	fd5fdc5289d681d59ff22d72e4de6e74c6c7aac6
ToppCell	Parenchyma_Control_(B.)-Immune-TX-MoAM-4\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	POC1A DDA1 ZNF619 KIF20B	3.06e-04	197	73	4	dc1c55e3aacc9d60d0f111c2f20f150ca296f011
ToppCell	cellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK9 SOCS3 CLEC3B LEPR	3.06e-04	197	73	4	56afed433887cb2766eb30f22aec195148db33ab
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CCR9 GPR183 AGAP6 WDR72	3.06e-04	197	73	4	cd9172af705f9589890252ab5e8b333ed754bea4
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SOCS3 CLEC3B LEPR	3.12e-04	198	73	4	1b9200e30f1d9b91bb0c6411c4f95208aedbe161
ToppCell	LAM-Endothelial-VasEndo-2\|Endothelial / Condition, Lineage and Cell class	SOCS3 CLEC3B LEPR CEMIP2	3.12e-04	198	73	4	92bccaec01f1dbb17d5efcba30f7f800f674ca96
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SOCS3 CLEC3B LEPR	3.12e-04	198	73	4	7e2d6e21b2b3d5a4a9f786890ec6ba2688a506cc
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SOCS3 CLEC3B LEPR	3.12e-04	198	73	4	55378e15360f867c9500b03293814965562ae55d
ToppCell	Endothelial_cells-Endothelial-A\|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id	MAST4 GNAQ LEPR CEMIP2	3.18e-04	199	73	4	2a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	AGAP5 MAP1S GANC GPR183	3.18e-04	199	73	4	bbb4798d6a24e756fea744a151ba67c1bafbac9a
ToppCell	cellseq-Endothelial-Endothelial_Vascular\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK9 SOCS3 CLEC3B LEPR	3.18e-04	199	73	4	307d29816a224193aa3d8c4540e128b2ad2e90b9
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PLEKHG4B GPR31 PKP2 GPR183	3.18e-04	199	73	4	26ea06960e8ea061a71756750b84489609f78162
ToppCell	distal-Endothelial-Bronchial_Vessel_2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SOCS3 OR52N5 CLEC3B OR52N1	3.18e-04	199	73	4	bd9090c13a38a35d50f676fdf11b68eec1340bd3
ToppCell	distal-Endothelial-Bronchial_Vessel_2-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SOCS3 OR52N5 CLEC3B OR52N1	3.18e-04	199	73	4	ddd6cad854d889d58c1e6bbcdfd96edce4fc9694
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MAST4 DOCK9 CLEC3B LEPR	3.18e-04	199	73	4	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 CLEC3B LEPR CEMIP2	3.24e-04	200	73	4	ec9a18576a3d08ddfceb70d114c4ab861fbb0d08
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MAST4 DOCK9 CLEC3B LEPR	3.24e-04	200	73	4	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MAST4 DOCK9 RNF213 LEPR	3.24e-04	200	73	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Artery-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DOCK9 SOCS3 CLEC3B LEPR	3.24e-04	200	73	4	622206c33640cb2694fe158e8dc55515bb7bd4f5
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Artery\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	MAST4 DOCK9 CLEC3B LEPR	3.24e-04	200	73	4	34b279804475ea58fbb052b96f44128c082627a9
ToppCell	medial-Endothelial-Capillary\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK9 CLEC3B LEPR CEMIP2	3.24e-04	200	73	4	fd4dcdc67db2a5dbdd54bd2ae975c66df904d4d8
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Artery\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	DOCK9 SOCS3 CLEC3B LEPR	3.24e-04	200	73	4	5b4a54cd81bc4d9f5e92798362239e1aa1b70bee
ToppCell	distal-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK9 SOCS3 CLEC3B CEMIP2	3.24e-04	200	73	4	7a355c3883fd409b2e0868164bb6e7ce4b745776
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	MAST4 DOCK9 CLEC3B LEPR	3.24e-04	200	73	4	8552cc7a439449b30b59760c3e8667217b9852b5
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 CLEC3B LEPR CEMIP2	3.24e-04	200	73	4	24e43d3d16d07571f77e0cd5b2e4758c6ff802cb
ToppCell	distal-3-Endothelial-Capillary\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SOCS3 CLEC3B LEPR CEMIP2	3.24e-04	200	73	4	bb792bfe34da99c400993155ffd8e0c15af29c26
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MAST4 DOCK9 CLEC3B LEPR	3.24e-04	200	73	4	7547d6339f9380d031cfd2cce21ac9a12491e085
ToppCell	medial-2-Endothelial-Capillary\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK9 CLEC3B LEPR CEMIP2	3.24e-04	200	73	4	e4f390dfd4dd25600f0f7a17c5523283a5966e92
Disease	Phakomatosis cesioflammea	GNA11 GNAQ	5.23e-06	2	68	2	C3838883
Disease	Congenital hemangioma	GNA11 GNAQ	5.23e-06	2	68	2	C0235753
Disease	Port-wine stain with oculocutaneous melanosis	GNA11 GNAQ	5.23e-06	2	68	2	C1274879
Disease	Malignant melanoma of iris	GNA11 GNAQ	5.21e-05	5	68	2	C0346373
Disease	Malignant melanoma of choroid	GNA11 GNAQ	5.21e-05	5	68	2	C0346388
Disease	human immunodeficiency virus infectious disease (is_marker_for)	SOCS3 C3 LEPR	7.91e-05	36	68	3	DOID:526 (is_marker_for)
Disease	obesity (implicated_via_orthology)	HDAC6 C3 GNA11 GNAQ LEPR	1.41e-04	215	68	5	DOID:9970 (implicated_via_orthology)
Disease	Uveal melanoma	GNA11 GNAQ	1.45e-04	8	68	2	C0220633
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP6	2.33e-04	10	68	2	DOID:1969 (implicated_via_orthology)
Disease	Antibody Deficiency Syndrome	C3 LEPR	6.96e-04	17	68	2	C0003257
Disease	Cannabis use initiation	KLHL29 SCGB2B2	7.82e-04	18	68	2	EFO_0007586
Disease	Immunologic Deficiency Syndromes	C3 LEPR	1.28e-03	23	68	2	C0021051
Disease	Albuminuria	GNAQ LEPR	1.40e-03	24	68	2	C0001925
Disease	cardiovascular age measurement	AGAP5 CTNNA3	2.04e-03	29	68	2	EFO_0803380

Protein segments in the cluster

Peptide	Gene	Start	Entry
EAFCAQFSKLHVRVT	ADCK2	161	Q7Z695
LISEAAQNSTRCHSF	GPR31	151	O00270
KSHSQCVFISRNFHT	C1orf185	66	Q5T7R7
AFCSLATTKRRHQQT	C3	871	P01024
VKTFSSCSLRSFQNF	ADAM32	356	Q8TC27
CHNKTANDFVFVSSS	DMXL1	2836	Q9Y485
CTNHVSAVRFSQQYS	AGAP6	106	Q5VW22
AISHSSQVARKCFSN	RAD54B	216	Q9Y620
SHFTCATDTENIRFV	GNAQ	326	P50148
RFTGHKDAVTCVNFS	POC1A	56	Q8NBT0
QLKVFVSRHSATFSS	MAP1S	56	Q66K74
QRSLSCSHEQFSFVE	FAM53B	226	Q14153
LRTHFCQGQNKVFST	OR4Q3	226	Q8NH05
QKQFLHRKFSFCSSV	GANC	826	Q8TET4
HRKFSFCSSVLINSF	GANC	831	Q8TET4
FTKLNNASSRSHSIF	KIF20B	341	Q96Q89
NLSKTTFHCCFRSEQ	LEPR	81	P48357
VFRKFATDNNCHVTL	TWNK	541	Q96RR1
TVASKFNQTCSHFRI	PARP14	1631	Q460N5
NSIRHSLSFNDCFVK	FOXA1	216	P55317
NFLSRQHTISFAACI	OR6S1	86	Q8NH40
CLLQHVSAFQRTFES	CTNNA3	146	Q9UI47
FSRFHADSVCKASNR	DDA1	16	Q9BW61
NANHSLAVFIKRCFT	DOCK9	1021	Q9BZ29
DFSKQVSSSAACHSR	PRMT7	251	Q9NVM4
KIRAFQHAFSTNDCS	FBXO45	106	P0C2W1
SHFTCATDTENIRFV	GNA11	326	P29992
DICFQVTQTIAFFHS	CCR9	296	P51686
CAFVKFSSHTEAQAA	CELF5	176	Q8N6W0
QKRHKNTFICFAITS	CEMIP2	76	Q9UHN6
RRHNKSSSAFTFTCN	FBXO40	466	Q9UH90
VEIRQFSSCSHRFSK	MAST4	896	O15021
SLFAFTNKITSVHSR	ELP2	656	Q6IA86
CFFNSVAVAARHAQT	HDAC6	621	Q9UBN7
QGHFQERSFCKALTS	DENND2D	401	Q9H6A0
EFCHNRKVLTIFSAS	PPEF2	496	O14830
DARQKAFSTCTAHIS	OR52N5	241	Q8NH56
RKAFSTFASHFTCVV	OR9A2	231	Q8NGT5
RQKAFSTCTAHFCAI	OR52N1	236	Q8NH53
LSERKTISFNHCFTQ	OR4D10	86	Q8NGI6
KRICHSFSSLFNLST	TMEM71	111	Q6P5X7
CTFQHFQELTKSAAS	SLC9C1	441	Q4G0N8
TSFAIKFFSAQTNRH	SERPINA4	381	P29622
SQRHSFQISLHFTVC	GPR183	281	P32249
RFVFHNTTFCIVNSH	OCRL	361	Q01968
RSNCTNHVSTERFSQ	AGAP5	126	A6NIR3
INFQTLTAFCNTFHI	CNOT1	2011	A5YKK6
KAASSFFSTQAHVAC	SPG11	1746	Q96JI7
FRSLKQVHLVSFQCS	RNF213	2796	Q63HN8
CGKSFSRSSFVIEHQ	ZNF189	181	O75820
TGEAFNCSSFVRKHQ	ZNF578	236	Q96N58
FCQKFSFVEHQRTHT	ZNF334	581	Q9HCZ1
DTSVLTFTFCFKQHT	LINC00052	86	Q96N35
TFTFCFKQHTHFTLN	LINC00052	91	Q96N35
CFLAFTQTKTFHEAS	CLEC3B	81	P05452
IFLQNSFCSLNTHRT	PLEKHG4B	361	Q96PX9
LECHKSFSRSSNFIT	ZNF774	266	Q6NX45
AKTLAVVHSFRSSQF	WDR72	141	Q3MJ13
ALINFSCFHASITNS	SLC12A3	541	P55017
QRHFFTLSVKTQSGT	SOCS3	76	O14543
TPQFSRCHFKSRNDS	MPL	346	P40238
CGKSFFQVSSLFRHQ	ZNF585A	191	Q6P3V2
HTNFCKDQSSRRVFN	ZC2HC1B	136	Q5TFG8
ECRKAFSQSSSLTQH	ZNF879	236	B4DU55
FQCNVHVKVFSTFSN	ZNF732	141	B4DXR9
HVKVFSTFSNSNQRR	ZNF732	146	B4DXR9
ECGKRFSQTSNFTQH	ZNF623	351	O75123
CFANVSVTERFAHSV	SCGB2B2	66	Q4G0G5
KTFSCSSRFIVHQRI	ZNF619	391	Q8N2I2
NLHCTFTLERFSLNT	UNC5C	776	O95185
SAAATFIQHECFQKS	PKP2	371	Q99959
ECGKFFTQRSSLTQH	ZNF501	26	Q96CX3
NTHVKCFSLAATRSN	TMOD3	226	Q9NYL9
QCGKAFRFSSSVRIH	ZNF14	591	P17017
KSFRNSSCLSDHFRI	ZNF266	331	Q14584
TLLEAASKFQFHTFC	KLHL29	406	Q96CT2